Patents by Inventor Werner Mederski

Werner Mederski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1-[(4-Ethynylphenyl)]-2-[(phenyl)]-pyrrolidine-1,2-dicarboxamide derivatives as inhibitors of coagulation factors xa and viia for the treatment of thromboses
    Publication number: 20070093472
    Abstract: Novel compounds of the formula (I), in which R, R1, R2 and R3 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
    Type: Application
    Filed: May 27, 2004
    Publication date: April 26, 2007
    Applicant: MERCK PATENT GMBH
    Inventors: Werner Mederski, Christos Tsaklakidis, Dieter Dorsch, Bertram Cezanne, Johannes Gleitz
  • Derivatives of phenoxy-n-?4-(isothiazolindin-1, 1-dioxid-2yl)phenyll-valerian-acid amide and other compounds as inhibitors of the coagulation factor xa in the treatment of thromboembolic diseases and tumors
    Patent number: 7199133
    Abstract: Novel compounds of formula (I), wherein D, W, X, Y, T and R1 have the meanings cited in claim 1, are inhibitors of coagulation factor Xa and can be used for the prophylaxis and/or therapy of thromboembolic diseases and in the treatment of tumors
    Type: Grant
    Filed: October 10, 2002
    Date of Patent: April 3, 2007
    Assignee: Merck Patent Gesellschaft
    Inventors: Dieter Dorsch, Bertram Cezanne, Christos Tsaklakidis, Werner Mederski, Johannes Gleitz, Christopher Barnes
  • Carboxylic acid amides
    Patent number: 7183277
    Abstract: Novel compounds of the formula I in which D, W, X, Y, T and R1 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: February 27, 2007
    Assignee: Merck Patent GmbH
    Inventors: Dieter Dorsch, Werner Mederski, Johannes Gleitz, Bertram Cezanne, Christos Tsaklakidis, Christopher Barnes
  • Aroyl semicarbazide derivatives against thromboembolic diseases
    Publication number: 20060241111
    Abstract: Novel compounds of the formula (I) in which Het, R1, R2 and R3 have the meaning indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
    Type: Application
    Filed: May 12, 2004
    Publication date: October 26, 2006
    Inventors: Werner Mederski, Christos Tsaklakidis, Dieter Dorsch, Bertram Cezanne, Johannes Gleitz
  • Process for the production of n-arylmorpholinones
    Publication number: 20060217550
    Abstract: The invention relates to a method for production of compounds of formula (I), where X has the meaning given in claim 1 and precursors for the same.
    Type: Application
    Filed: July 16, 2004
    Publication date: September 28, 2006
    Inventors: Dieter Dorsch, Bertram Cezanne, Werner Mederski, Christos Tsaklakidis, Hanns Wurziger
  • Method for the production of pyrrolidine-1,2-dicarboxylic acid-1-(phenyl(-amide))-2-(phenyl(-amide)) derivatives and 1-(phenylcarbamoyl)-pyrrolidine-2-carboxylic acid derivatives as intermediate products
    Publication number: 20060211692
    Abstract: Process for the preparation of compounds of the formula I in which R, R1, R2 and R3 are as defined in Patent claim 1, and compounds of the formula IV in which R and R1 are as defined in Patent claim 1, are intermediates for the preparation of the compounds of the formula I.
    Type: Application
    Filed: March 9, 2004
    Publication date: September 21, 2006
    Inventors: Werner Mederski, Christos Tsaklakidis, Dieter Dorsch, Bertram Cezanne, Johannes Gleitz
  • Carbonyl compounds
    Publication number: 20060183739
    Abstract: Novel compounds of the formula (I), in which D, E, G, W, X, Y, T, R1 and R2 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
    Type: Application
    Filed: March 8, 2004
    Publication date: August 17, 2006
    Inventors: Christos Tsaklakidis, Dieter Dorsch, Werner Mederski, Bertram Cezanne, Johannes Gleitz
  • Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor xa inhibitors for the treatment of thromboses
    Publication number: 20060183742
    Abstract: Novel compounds of the formula (I), in which R, R1, R2 and R3 have the meanings indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
    Type: Application
    Filed: March 9, 2004
    Publication date: August 17, 2006
    Inventors: Werner Mederski, Christos Tsaklakidis, Dieter Dorsch, Bertram Cezanne, Johannes Gleitz
  • Heterocyclic amides and their use treating thromboembolic diseases and tumors
    Publication number: 20060135515
    Abstract: Novel compounds of the formula (I), in which D, W, X, Y, T and R1 have the meaning indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours
    Type: Application
    Filed: September 18, 2003
    Publication date: June 22, 2006
    Inventors: Dieter Dorsch, Bertram Cezanne, Werner Mederski, Christos Tsaklakidis, Johannes Gleitz, Christopher Barnes
  • Quinazolinones
    Patent number: 7060706
    Abstract: Quinazolinones of formula (I) in which R, R1, R2, R3, R4, Y, n and m have the meaning indicated in Patent claim 1, and their salts or solvates as glycoprotein IbIX antagonists
    Type: Grant
    Filed: September 13, 2000
    Date of Patent: June 13, 2006
    Assignee: 3-Dimensional Pharmaceuticals, Inc.
    Inventors: Werner Mederski, Ralf Devant, Gerhard Barnickel, Sabine Bernotat-Danielowski, Guido Melzer, Bertram Cezanne, Daljit Dhanoa, Bao-Ping Zhao, James Rinker, Mark Player, Richard Soll
  • Ethynyl derivatives as factor xa inhibitors
    Publication number: 20060084648
    Abstract: Novel compounds of the formula (I), in which R1, R2, R3, X and Y have the meaning indicated in Patent claim 1, are inhibitors ocoagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
    Type: Application
    Filed: January 30, 2004
    Publication date: April 20, 2006
    Applicant: Merck Patent GmbH
    Inventors: Werner Mederski, Christos Tsaklakidis, Dieter Dorsch, Bertram Cezanne, Johannes Gleitz, Christoph van Amsterdam
  • Carboxamide derivatives and their use as factor xa inhibitors
    Publication number: 20060074072
    Abstract: Novel compounds of the formula (I) in which R1, D, X, W, Y and T have the meaning indicated in Patent Claim (1), e.g. (II), are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
    Type: Application
    Filed: January 8, 2004
    Publication date: April 6, 2006
    Inventors: Dieter Dorsch, Bertram Cezanne, Werner Mederski, Christos Tsaklakidis, Johannes Gleitz, Christoph Van Amsterdam
  • Carboxamides
    Publication number: 20060052376
    Abstract: Novel compounds of the formula (I), in which D, W, X, Y, T, m and R1 have the meaning indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
    Type: Application
    Filed: October 30, 2003
    Publication date: March 9, 2006
    Applicant: Merck Patent GmbH
    Inventors: Dieter Dorsch, Bertram Cezanne, Werner Mederski, Christos Tsaklakidis, Hanns Wurziger, Johannes Gleitz, Christoph Van Amsterdam
  • 4-Amino-quinazolines
    Publication number: 20060019974
    Abstract: Quinazolines of the formula (I) in which R, R1, R2, R3, R4 and Y have the meaning indicated in Patent claim 1, and their salts or solvates as glycoprotein IbIX antagonists.
    Type: Application
    Filed: September 17, 2001
    Publication date: January 26, 2006
    Inventors: Werner Mederski, Ralf Devant, Maria Devant, Gerhard Barnickel, Sabine Bernotat-Danielowski, James Vickers, Bertram Cezanne, Daljit Dhanoa, Bao-Ping Zhao, James Rinker, Mark Player, Edward Jaeger, Richard Soll
  • Substituted biphenyl derivatives
    Patent number: 6946489
    Abstract: The invention relates to compounds of the formula I in which R1, R2, R3, R4 and X have the meaning indicated in the text. The compounds act as inhibitors of factors Xa and VIIa and can therefore be employed for the control and prevention of thromboembolic conditions such as thrombosis, myocardial infarct, arteriosclerosis, inflammation, apoplexy, angina pectoris, restenosis after angioplasty and intermittent claudication.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: September 20, 2005
    Assignee: Merck Patent GmbH
    Inventors: Horst Juraszyk, Dieter Dorsch, Werner Mederski, Christos Tsaklakidis, Christopher Bames, Johannes Gleitz
  • 2-(Phenyl)-2h-pyrazole-3-carboxylic acid-n-4-(thioxo-heterocyclyl)-phenyl-amide derivatives and corresponding imino-heterocyclyl derivatives and relates compounds for use as inhibitors of the coagulation factors xa and/or viia for treating thromboses
    Publication number: 20050203127
    Abstract: The invention relates to the novel compounds of formula (I), wherein D, M, W, X, Y, T, R1 and R1? are defined as in patent claim 1. The inventive compounds are inhibitors of coagulation factor Xa and can be used in the prophylaxis and/or therapy of thromboembolic diseases and in the treatment of tumors.
    Type: Application
    Filed: June 5, 2003
    Publication date: September 15, 2005
    Inventors: Bertram Cezanne, Dieter Dorsch, Werner Mederski, Christos Tsaklakidis, Johannes Gleitz, Christopher Barnes
  • Biurethane derivatives
    Patent number: 6943179
    Abstract: Novel compounds of the formula I in which X, Y, Z, R, R1, R2 and R3 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of tromboembolic diseases and for the treatment of tumors
    Type: Grant
    Filed: February 27, 2002
    Date of Patent: September 13, 2005
    Assignee: Merck Patent GmbH
    Inventors: Werner Mederski, Bertram Cezanne, Dieter Dorsch, Christos Tsaklakidis, Johannes Gleitz, Christopher Barnes
  • Process for the preparation of cyclic imides in the presence of polyphosphoric acid
    Publication number: 20050182260
    Abstract: The present invention relates to a novel process for the preparation of N-substituted cyclic imides. N-substituted cyclic imides are valuable intermediates which can be employed, for example, for the synthesis of pharmacologically valuable compounds.
    Type: Application
    Filed: April 7, 2003
    Publication date: August 18, 2005
    Inventors: Werner Mederski, Manfred Baumgarth, Martina Germann, Dieter Kux, Thomas Weitzel
  • N-'4-(2-imino-pyrrolidin-1-yl)phenyl!-acetamide and corresponding piperidine derivatives as factor xa inhibitors for the treatment of thrombo-embolic diseases
    Publication number: 20050176760
    Abstract: Novel compounds of the formula I in which D, M, W, X, Y, T and R1 are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
    Type: Application
    Filed: March 7, 2003
    Publication date: August 11, 2005
    Applicant: Merck Patent GmbH
    Inventors: Bertram Cezanne, Dieter Dorsch, Werner Mederski, Christos Tsaklakidis, Christopher Barnes, Johannes Gleitz
  • Semicarbazide derivatives for combating thromboembolic diseases
    Publication number: 20050171102
    Abstract: Novel compounds of the formula I in which R, R1, R1, X are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
    Type: Application
    Filed: April 7, 2003
    Publication date: August 4, 2005
    Inventors: Werner Mederski, Dieter Dorsch, Christos Tsaklakidis, Christopher Barnes, Bertram Cezanne, Johannes Gleitz