Patents by Inventor Werner Mederski

Werner Mederski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AMINO INDAZOLE DERIVATIVES
    Publication number: 20090036508
    Abstract: Compounds of the formula I in which X, Y, R1, R2, R3 and R4 have the meanings indicated in claim 1, are inhibitors of CHK1 CHK2 and SGK kinases and can be employed, inter alia, for the treatment of cancer.
    Type: Application
    Filed: January 10, 2007
    Publication date: February 5, 2009
    Inventors: Markus Klein, Rolf Gericke, Werner Mederski, Norbert Beier, Florian Lang
  • Squaric Acid Derivatives as Protein Kinase Inhibitors
    Publication number: 20080312244
    Abstract: Compounds of the formula I, in which R, X, R1, R2, R3, R4 and R5 have the meanings indicated in Claim 1, are inhibitors of CHK1 CHK2 and SGK kinases and can be employed, inter alia, for the treatment of cancer.
    Type: Application
    Filed: June 30, 2006
    Publication date: December 18, 2008
    Inventors: Werner Mederski, Ulrich Emde, Gerhard Barnickel, Frank Zenke, Hartmut Greiner, Frank Stieber
  • Squaric Acid Derivatives
    Publication number: 20080262096
    Abstract: Novel squaric acid compounds of the formula (I), in which R, R1, R1?, R2 and X have the meanings indicated in Claim (1), are SGK inhibitors and can be used for the treatment of SGK-induced diseases and complaints, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, generally in fibroses and inflammatory processes of any type.
    Type: Application
    Filed: December 9, 2005
    Publication date: October 23, 2008
    Inventors: Werner Mederski, Rolf Gericke, Dieter Dorsch, Markus Klein, Norbert Beier, Florian Lang
  • Squaric Acid Derivatives II
    Publication number: 20080234266
    Abstract: Compounds of the formula (I), in which R, X, X? and R2, R2?, R2?, R3?, R2?? and R7 have the meanings indicated in claim 1, are inhibitors of CHK1 CHK2 and SGK kinases and can be employed, inter alia, for the treatment of cancer.
    Type: Application
    Filed: June 30, 2006
    Publication date: September 25, 2008
    Inventors: Werner Mederski, Ulrich Emde, Gerhard Barnickel, Frank Zenke, Hartmut Greiner, Frank Stieber
  • 3-Oxoindazolesquaric Acid Derivatives
    Publication number: 20080234348
    Abstract: Novel squaric acid compounds of the formula (I), in which R1, R2, R2?, R2? and X have the meanings indicated in claim 1, are inhibitors of CHK1 CHK2 and SGK kinases and can be used for the treatment of diseases and complaints such as cancer, diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, generally in fibroses and inflammatory processes of any type.
    Type: Application
    Filed: August 2, 2006
    Publication date: September 25, 2008
    Inventors: Werner Mederski, Rolf Gericke, Markus Klein, Norbert Beier, Florian Lang
  • Ethynyl derivatives as factor Xa inhibitors
    Patent number: 7427618
    Abstract: Novel compounds of the formula (I), in which R1, R2, R3, X and Y have the meaning indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.
    Type: Grant
    Filed: January 30, 2004
    Date of Patent: September 23, 2008
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Werner Mederski, Christos Tsaklakidis, Dieter Dorsch, Bertram Cezanne, Johannes Gleitz, Christoph van Amsterdam
  • Acyl Hydrazines as Kinase Inhibitors, in Particular for Sgk
    Publication number: 20080167380
    Abstract: Novel acyl hydrazides of the formula (I), in which R1-R9 have the meanings indicated in claim 1, are SGK inhibitors and can be used for the treatment of SGK-induced diseases and complaints, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, generally in fibroses and inflammatory processes of any type.
    Type: Application
    Filed: March 10, 2006
    Publication date: July 10, 2008
    Inventors: Rolf Gericke, Dieter Dorsch, Werner Mederski, Markus Klein, Norbert Beier, Florian Lang
  • Heterocyclic Carbonyl Compounds
    Publication number: 20080090882
    Abstract: Novel heterocyclic compounds of the formula (I), in which R1, D, W, T and T? have the meanings indicated in Claim 1, are SGK inhibitors and can be used for the treatment of SGK-induced diseases and conditions, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and kidney diseases, generally in fibroses and inflammatory processes of any type.
    Type: Application
    Filed: April 4, 2005
    Publication date: April 17, 2008
    Applicant: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Rolf Gericke, Werner Mederski, Norbert Beier, Florian Lang
  • Carbonyl Compounds Which Can be Used as Inhibitors of Coagulation Factor Xa
    Publication number: 20080081814
    Abstract: Novel compounds of the formula (I), in which D, E, G, W, X, Y, T, R1 and R2 have the meaning indicated in Patent Claim (1), are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
    Type: Application
    Filed: September 1, 2005
    Publication date: April 3, 2008
    Inventors: Bertram Cezanne, Dieter Dorsch, Werner Mederski, Christos Tsaklakidis, Johannes Gleitz
  • Ortho-Substituted N'-Benzylidene-(3-Hydroxyphenyl)Acethydrazides
    Publication number: 20080032983
    Abstract: Novel ortho-substituted N?-benzylidene-(3-hydroxyphenyl)acetohydrazides of the formula (I), in which R1-R9 have the meanings indicated in Claim 1, are SGK inhibitors and can be used for the treatment of SGK-induced diseases and conditions, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and kidney diseases, generally in fibroses and inflammatory processes of any type.
    Type: Application
    Filed: June 6, 2005
    Publication date: February 7, 2008
    Inventors: Rolf Gericke, Dieter Dorsch, Werner Mederski, Norbert Beier, Florian Lang
  • Medicaments Comprising Carbonyl Compounds, And The Use Thereof
    Publication number: 20080003214
    Abstract: Use of compounds of the formula (I) in which D, E, G, W, X, Y, T, R1 and R2 have the meaning indicated in Patent Claim 1, for the prophylaxis and/or therapy of thromboembolic diseases
    Type: Application
    Filed: August 24, 2005
    Publication date: January 3, 2008
    Inventors: Bertram Cezanne, Dieter Dorsch, Werner Mederski, Christos Tsaklakidis, Johannes Gleitz
  • Tetrahydropyran Derivatives as Antidiabetics
    Publication number: 20070299065
    Abstract: Novel compounds of the formula (I), in which T, E, R, R?, R?, R1, R2 and R2? have the meanings indicated in patent Claim 1, are suitable as antidiabetics.
    Type: Application
    Filed: November 7, 2005
    Publication date: December 27, 2007
    Applicant: MERCK PATENT GMBH
    Inventors: Werner Mederski, Christoph Van Amsterdam, Christa Burger, Hartmut Greiner
  • 4-Amino-quinazolines
    Publication number: 20070293667
    Abstract: Quinazolines of the formula I in which R, R1, R2, R3, R4 and Y have the meaning indicated in Patent Claim 1, and their salts or solvates as glycoprotein IbIX antagonists.
    Type: Application
    Filed: December 14, 2005
    Publication date: December 20, 2007
    Inventors: Werner Mederski, Ralf Devant, Gerhard Barnickel, Sabine Bernotat-Danielowski, James Vickers, Bertram Cezanne, Daljit Dhanoa, Bao-Ping Zhao, James Rinker, Mark Player, Edward Jaeger, Richard Soll
  • Proline Derivatives
    Publication number: 20070265259
    Abstract: Novel compounds of the formula (I), in which X, Y, R1, R2, R3, R4 and n have the meaning indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
    Type: Application
    Filed: September 16, 2005
    Publication date: November 15, 2007
    Inventors: Werner Mederski, Christos Tsaklakidis, Dieter Dorsch, Bertram Cezanne, Johannes Gleitz
  • 3-Aminoindazoles
    Publication number: 20070232620
    Abstract: Novel 3-aminoindazoles of the formula (I) are SGK inhibitors and can be used for the treatment of SGK-induced diseases and conditions, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, generally in fibrosis and inflammatory processes of any type.
    Type: Application
    Filed: April 4, 2005
    Publication date: October 4, 2007
    Inventors: Dieter Dorsch, Lars Thore Burgdorf, Rolf Gericke, Norbert Beier, Werner Mederski, Florian Lang
  • Phenyl derivatives
    Patent number: 7273867
    Abstract: Novel compounds of the formula I in which W, X, Y, T, R1 and R2 are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: September 25, 2007
    Assignee: Merck Patent GmbH
    Inventors: Dieter Dorsch, Werner Mederski, Christos Tsaklakidis, Bertram Cezanne, Johannes Gleitz, Christopher Barnes
  • Prolinylarylacetamides
    Publication number: 20070185189
    Abstract: Novel compounds of the formula (I), in which R, R1, R2, R3, X, X? and Y have the meaning indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
    Type: Application
    Filed: November 26, 2004
    Publication date: August 9, 2007
    Inventors: Werner Mederski, Christos Tsaklakidis, Dieter Dorsch, Bertram Cezanne, Johannes Gleitz
  • Urea derivatives
    Publication number: 20070161623
    Abstract: Novel compounds of the formula (I), in which X—Y-D-E, R1, R2 and R3 have the meanings indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours
    Type: Application
    Filed: January 7, 2005
    Publication date: July 12, 2007
    Applicant: MERCK PATENT GMBH
    Inventors: Werner Mederski, Christos Tsaklakidis, Dieter Dorsch, Bertram Cezanne, Johannes Gleitz
  • Prolinyl derivatives for the treatment of thrombosis
    Publication number: 20070135507
    Abstract: Novel compounds of the formula (I), in which R, R1, R2, R3 and R4 have the meaning indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
    Type: Application
    Filed: March 4, 2005
    Publication date: June 14, 2007
    Inventors: Werner Mederski, Christos Tsaklakidis, Dieter Dorsch, Bertram Cezanne, Johannes Gleitz
  • Carboxamide derivatives
    Publication number: 20070123509
    Abstract: Novel compounds of the formula (I) in which D, E, Q, T, X, Y, Z, Z?, R1, R4 and R4? have the meanings indicated in patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours
    Type: Application
    Filed: November 19, 2004
    Publication date: May 31, 2007
    Inventors: Bertram Cezanne, Dieter Dorsch, Werner Mederski, Christos Tsaklakidis, Johannes Gleitz