Patents by Inventor Werner Mederski

Werner Mederski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Urethane derivatives
    Publication number: 20030171579
    Abstract: The invention relates to novel compounds of formula (I), wherein R, R1 and R2 have the meaning as cited claim 1. According to the invention, the compounds are inhibitors of the coagulation factors Xa and VIIa and can be used for treating thrombosis, myocardial infarct, arteriosclerosis, inflammation, apoplexy, angina pectoris, restenosis post-angioplasty, intermittent claudication, tumours, tumour related illnesses and/or tumour metastases.
    Type: Application
    Filed: January 27, 2003
    Publication date: September 11, 2003
    Inventors: Werner Mederski, Horst Juraszyk, Dieter Dorsch, Christos Tsaklakidis, Johannes Gleitz, Christopher Barnes
  • Glycinamides
    Publication number: 20030166694
    Abstract: Novel compounds of the formula I 1
    Type: Application
    Filed: November 27, 2002
    Publication date: September 4, 2003
    Inventors: Dieter Dorsch, Werner Mederski, Christos Tsaklakidis, Johannes Gleitz, Christopher Barnes
  • N-substituted 1-amino-1,1-dialkylcarboxylic acid derivatives
    Publication number: 20030162814
    Abstract: The novel compounds of formula (I), wherein R1, R2, R2′, R2″, R3, R4, R5, R5′, R5″, R5′″, R″″, X, Y, U, V and W have the meanings given in patent claim no. 1, are inhibitors of the coagulation factors Xa and VIIa and can be used for treating thromboses, myocardial infarction, arteriosclerosis, inflammations, apoplexy, angina pectoris, restenosis following angioplasty, intermittent claudication, tumours, tumour diseases and/or tumour metastases.
    Type: Application
    Filed: January 23, 2003
    Publication date: August 28, 2003
    Inventors: Horst Juraszyk, Dieter Dorsch, Werner Mederski, Christos Tsaklakidis, Christopher Barnes, Johannes Gleitz
  • Aminosulfonylbiphenyl derivatives
    Publication number: 20030135055
    Abstract: The invention relates to compounds of the formula I 1
    Type: Application
    Filed: August 21, 2002
    Publication date: July 17, 2003
    Inventors: Dieter Dorsch, Horst Juraszyk, Werner Mederski, Christos Tsaklakidis, Sabine Bernotat-Danielowski, Guido Melzer, Johannes Gleitz, Christopher Barnes, James Vickers
  • Imidazo (4,5-C) pyridine-4-one derivatives with factor XA inhibiting effect
    Patent number: 6492384
    Abstract: The invention relates to novel compounds of formula (I), wherein R, R1, R2, R3, n and p have the meaning defined in claim 1. Compounds are inhibitors of clotting factor Xa and can be used for the prophylaxis and/or therapy of thrombo-embolic disorders.
    Type: Grant
    Filed: December 13, 2001
    Date of Patent: December 10, 2002
    Assignee: Merck Patent GmbH
    Inventors: Werner Mederski, Horst Juraszyk, Hanns Wurziger, Joachim Gante, Dieter Dorsch, Hans-Peter Buchstaller, Sabine Bernotat-Danielowski, Guido Melzer, Soheila Anzali
  • Biphenyl derivatives
    Patent number: 6380430
    Abstract: Novel compounds of the formula I in which X, R1, R2, R3, R4 and R5 have the meaning indicated in Patent Claim 1, are inhibitors of the coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders.
    Type: Grant
    Filed: December 29, 2000
    Date of Patent: April 30, 2002
    Assignee: Merck Patent Gesellschaft mit beschraenkterHaftung
    Inventors: Dieter Dorsch, Horst Juraszyk, Werner Mederski, Joachim Gante, Hanns Wurziger, Hans-Peter Buchstaller, Sabine Bernotat-Danielowski, Guido Melzer
  • Benzothia(oxa)diazol derivatives and their use as endothelin-receptor antagonists
    Patent number: 6197800
    Abstract: Novel compounds of the formula I in which R is X is O or S, and R1, R2, R3, R4, R5 and R6 have the meaning indicated in patent claim 1, or a tautomeric ring-closed form, and the (E) isomers and their salts exhibit endothelin receptor-antagonistic properties.
    Type: Grant
    Filed: March 27, 2000
    Date of Patent: March 6, 2001
    Assignee: Merck Patent Gesellschaft mi beschraenkter Haftung
    Inventors: Dieter Dorsch, Mathias Osswald, Werner Mederski, Claudia Wilm, Maria Christadler, Claus Jochen Schmitges
  • Imidazopyridines
    Patent number: 6037349
    Abstract: Imidazopyridine derivatives ad pharmacologically acceptable salts having antagonistic properties towards angiotensin II can be used for the treatment of hypertension, aldosteronism and cardiac insufficiency.
    Type: Grant
    Filed: January 4, 1999
    Date of Patent: March 14, 2000
    Assignee: Merck Patent GmbH
    Inventors: Werner Mederski, Johannes Sombroek, Pierre Schelling, Norbert Beier, Ingeborg Lues, Klaus-Otto Minck
  • 2,1,3-benzothia(OXA)diazole derivatives having an endothelin receptor antagonistic effect
    Patent number: 6017939
    Abstract: The invention concerns compounds of formula (I),in which R is (i), (ii) or (iii); n is 0, 1 or 2; X means O or S; and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have different meanings, or a cyclized tautomeric shape. The invention also concerns the (E) isomers and salts of these compounds which display endothelin receptor antagonistic properties.
    Type: Grant
    Filed: November 12, 1998
    Date of Patent: January 25, 2000
    Assignee: Merck Patent Gesellschaft
    Inventors: Dieter Dorsch, Mathias Osswald, Werner Mederski, Claudia Wilm, Claus Schmitges, Maria Christadler, Soheila Anzali
  • Endothelin receptor antagonists
    Patent number: 5883090
    Abstract: This invention relates to pyridizinone derivatives of formula I ##STR1## wherein the various substituents are defined in the specification, and salts thereof, which have useful pharmacological properties, in particular endothelin receptor-antagonistic properties. The compounds are thus useful for the treatment of illnesses associated with endothelin activities, such as hypertension, cardiac insufficiency, coronary heart disease, renal, cerebral and myocardial ischaemia, renal insufficiency, cerebral infarct, subarachnoid haemorrhage, arteriosclerosis pulmonary high blood pressure, inflammations, asthma, prostate hyperplasia, endotoxic shock and in complications after the administration of immunosuppressants which produce renal vasoconstriction.
    Type: Grant
    Filed: June 6, 1997
    Date of Patent: March 16, 1999
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Dieter Dorsch, Mathias Osswald, Werner Mederski, Claudia Wilm, Claus Jochen Schmitges, Maria Christadler
  • Endothelin receptor antagonists
    Patent number: 5821256
    Abstract: Novel compounds of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and X have the meaning indicated in claim 1, and their salts exhibit endothelin receptor-antagonistic properties.
    Type: Grant
    Filed: August 15, 1996
    Date of Patent: October 13, 1998
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Dieter Dorsch, Mathias Osswald, Werner Mederski, Claudia Wilm, Claus J. Schmitges, Maria Christadler
  • Imidazopyridines
    Patent number: 5798364
    Abstract: Imidazopyridine derivatives and pharmacologically acceptable salts having antagonistic properties towards angiotensin II can be used for the treatment of hypertension, aldosteronism and cardiac insufficiency.
    Type: Grant
    Filed: October 4, 1996
    Date of Patent: August 25, 1998
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Werner Mederski, Johannes Sombroek, Pierre Schelling, Norbert Beier, Ingeborg Lues, Klaus-Otto Minck
  • Endothelin receptor antagonists
    Patent number: 5731321
    Abstract: Novel compounds of the formula I ##STR1## in which --Y--Z--, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the meanings as stated in the specification, and their salts show endothelin receptor antagonist properties.
    Type: Grant
    Filed: August 1, 1996
    Date of Patent: March 24, 1998
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Werner Mederski, Mathias Osswald, Dieter Dorsch, Claudia Wilm, Claus J. Schmitges, Maria Christadler
  • Endothelin receptor antagonists
    Patent number: 5726194
    Abstract: Novel compounds of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, --A.dbd.B--C.dbd.D--, Ar and X have the meaning indicated in claim 1, and their salts show endothelin receptor-antagonistic properties.
    Type: Grant
    Filed: March 18, 1996
    Date of Patent: March 10, 1998
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Mathias Osswald, Werner Mederski, Dieter Dorsch, Claudia Wilm, Claus Schmitges, Maria Christadler
  • Endothelin receptor antagonists
    Patent number: 5700807
    Abstract: Novel compounds of the formula ##STR1## in which --Y--Z--, R.sup.1 R.sup.2, R.sup.3, R.sup.4, R.sup.5 and X have the meaning indicated and their salts show endothelin receptor-antagonistic properties.
    Type: Grant
    Filed: July 26, 1996
    Date of Patent: December 23, 1997
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Mathias Osswald, Dieter Dorsch, Werner Mederski, Claudia Wilm, Claus J. Schmitges, Maria Christadler
  • Imidazopyridines as pharmaceutical agents
    Patent number: 5684015
    Abstract: Described herein are novel imidazopyridine derivatives of the formula I ##STR1## wherein R is ##STR2## and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined in Patent Claim 1, and their salts, which exhibit antagonistic properties towards angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.
    Type: Grant
    Filed: September 14, 1995
    Date of Patent: November 4, 1997
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Werner Mederski, Matthias Osswald, Pierre Schelling, Klaus-Otto Minck, Dieter Dorsch, Norbert Beier, Ingeborg Lues
  • Imidazopyridines
    Patent number: 5532276
    Abstract: Novel imidazopyridine derivatives of the formula ##STR1## wherein R is ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, Ar.sup.1, X and Y are as defined in the specification, and their salts, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.
    Type: Grant
    Filed: December 5, 1994
    Date of Patent: July 2, 1996
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Werner Mederski, Dieter Dorsch, Mathias Osswald, Norbert Beier, Pierre Schelling, Klaus-Otto Minck, Ingeborg Lues
  • Imidazopyridines
    Patent number: 5476857
    Abstract: Novel imidazopyridine derivatives of formula I: ##STR1## wherein R is ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y are as defined herein, and their salts, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.
    Type: Grant
    Filed: June 17, 1993
    Date of Patent: December 19, 1995
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Werner Mederski, Dieter Dorsch, Norbert Beier, Pierre Schelling, Ingeborg Lues, Klaus-Otto Minck, Mathias Osswald
  • Imidazopyridines as angiotensin II antagonists
    Patent number: 5438063
    Abstract: Novel imidazopyridine derivatives of formula I ##STR1## wherein ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y are as defined herein, and their salts, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.
    Type: Grant
    Filed: June 6, 1994
    Date of Patent: August 1, 1995
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Mathias Osswald, Werner Mederski, Dieter Dorsch, Pierre Schelling, Norbert Beier, Ingeborg Lues, Klaus-Otto Minck
  • Imidazopyridines
    Patent number: 5405964
    Abstract: Novel imidazopyridine derivatives of formula I ##STR1## and X, --Y.dbd.Z--, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 as defined herein, and their salts, exhibit antagonistic properties towards angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.
    Type: Grant
    Filed: October 22, 1993
    Date of Patent: April 11, 1995
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Werner Mederski, Dieter Dorsch, Andreas Bathe, Thorsten Hartig, Mathias Osswald, Norbert Beier, Pierre Schelling, Klaus-Otto Minck, Ingeborg Lues