Publication number: 20040038858
Abstract: Compounds of the formula (I), in which the variables have the following meaning, D is phenyl or pyridyl, each of which is unsubstituted or monosubstituted or polysubstituted by Hal, A, OR2, N(R2)2, NO2, CN, COOR2 or CON(R2)2; R1 is H, Ar, Het, cycloalkyl or A, which may be substituted by OR2, SR2, N(R2)2, Ar, Het, cycloalkyl, CN, COOR2 or CON(R2)2; R2 is H or A; E is phenylene, which may be monosubstituted or polysubstituted by Hal, A, OR2, N(R2)2, NO2, CN, COOR2 or CON(R2)2, or is piperidine-1,4-diyl; W is AR, Het or N(R2)2 and, if E=piperidine-1,4-diyl, is alternatively R2 or cycloalkyl, X is NH or O, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
Type:
Application
Filed:
June 16, 2003
Publication date:
February 26, 2004
Inventors:
Dieter Dorsch, Werner Mederski, Christos Tsaklakidis, Bertram Cezanne, Johannes Gleitz, Christopher Barnes