Abstract: The disclosure provides for compounds and methods for modulating or inhibiting TEAD. Further provided herein are pharmaceutical compositions comprising the TEAD inhibitors and methods of treatment using the TEAD inhibitors or the pharmaceutical compositions.

Abstract: Described herein are MAT2A inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with MAT2A.

Abstract: Described herein are DGKalpha inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with DGKalpha.

Abstract: The present invention discloses a video processing circuit, which is coupled to a memory chip and includes an image processing circuit. The image processing circuit includes a first channel, a second channel and a compression circuit. The two channels process first image data and second image data to generate first processed image data and second processed image data, respectively. The compression circuit compresses the first processed image data and the second processed image data to generate first compressed image data and second compressed image data, respectively. A memory block in the memory chip is configured as a ring buffer shared by the first channel and the second channel so as to store the first compressed image data and the second compressed image data.

Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of anemia.

Abstract: Described herein are DGKalpha inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with DGKalpha.

Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for treating a SARS-CoV-2 infection.

Abstract: Aspects of the present disclosure address systems and methods for driver resizing using a transition-based capacitance increase margin. An integrated circuit (IC) design stored in a database in memory is accessed. The IC design comprises a net comprising a set of driver cells. A capacitance increase margin for resizing an initial driver cell is determined based on a total capacitance of the net and transition time target associated with the initial driver cell. An alternative driver cell is selected from a library to resize the initial driver cell and is used to replace the initial driver cell in the net. The alternative driver is selected such that a pin capacitance of the alternative driver cell exceeds an initial pin capacitance corresponding to the initial driver cell by no more than the capacitance increase margin.

Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of inflammatory bowel disease.

Abstract: The present disclosure provides a use of a novel environment-friendly agricultural chemical, and belongs to the field of agricultural chemicals. It is found in the present disclosure that methyl 4-hydroxyphenylacetate may be used for controlling plants and preparing herbicides. The methyl 4-hydroxyphenylacetate in the present disclosure has a use concentration greater than 150 mmol/L. The herbicide is prepared by using the methyl 4-hydroxyphenylacetate as an active ingredient in the present disclosure has a good controlling and killing effect on perennial herbs or Half-shrubby plants, especially Eupatorium adenophorum, and has low toxicity, no harm, and no solvent residues after use.

Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of anemia.

Abstract: The disclosure relates to the field of electric vehicles, and in particular provides a vehicle refrigerator control method, a storage medium, and a vehicle, aiming to solve the problems of how to implement the intelligent identification of items stored in a vehicle refrigerator, and of controlling the vehicle refrigerator based on information of the stored item and vehicle state information. To this end, the method of the disclosure includes: obtaining item information of a vehicle refrigerator; obtaining a real-time temperature and a target temperature of the vehicle refrigerator; obtaining vehicle state information; and controlling the vehicle refrigerator based on the real-time temperature, the target temperature, and the vehicle state information.

Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of inflammatory bowel disease.

Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for treating a SARS-CoV-2 infection.

Abstract: An air supply assembly for a refrigerator, includes: an air duct cover plate defining, together with a refrigerator liner, an air supply space and configured to isolate the air supply space from a storage space in a compartment of the refrigerator, and a centrifugal wind wheel arranged in the air supply space, and axially sucking air in and blowing the air out towards a peripheral side, wherein a plurality of air return ports are provided in the air duct cover plate to allow air in the storage space to enter the air supply space; and the centrifugal wind wheel abuts against an inner side of the air duct cover plate and is configured to suck air in from a rear side thereof, such that air entering the air supply space via the air return ports is sucked in from the rear side of the centrifugal wind wheel.

Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of anemia.

Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for treating a SARS-CoV-2 infection.

Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of inflammatory bowel disease.

Abstract: A system includes a machine configured to perform operations including accessing an integrated circuit design including a buffer tree that interconnects a plurality of inputs and buffers. The buffer tree includes a baseline timing characteristic. The operations include identifying a set of candidate solutions for improving the baseline timing characteristic using an initial timing model and selecting a subset of candidate solutions that have a timing characteristic lower than the baseline timing characteristic. Then the subset of candidate solutions are evaluated using a detailed timing model and based on determining that at least one candidate solution in the subset has a timing characteristic that is better than the baseline timing characteristic, selecting a candidate solution from the set of candidate solutions, and updating the buffer tree based on the candidate solution.

Abstract: Aspects of the present disclosure address systems and methods for performing a machine-learning based clustering of clock sinks during clock tree synthesis. An integrated circuit (IC) design comprising a clock net that includes a plurality of clock sinks is accessed. An initial number of clusters to generate from the set of clock sinks is determined using a machine-learning model. A first set of clusters is generated from the set of clocks sinks and includes the initial number of clusters. A timing analysis is performed to determine whether each cluster in the first set of clusters satisfies design rule constraints. The initial number of clusters is adjusted based on the timing analysis and a clustering solution is generated based on the adjusted number of clusters.