Abstract: Provided are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases associated with or characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

Abstract: Systems, methods, media, and other such embodiments are described for placement of cells in a multi-level routing tree, where placement of a mid-level parent node between a grandparent node and a set of child nodes is not set. One embodiment involves generating a first routing subregion between a first set of child nodes associated with a first grandparent node and a first connecting route from the first routing subregion to the first grandparent node, which together are set as a first routing region comprising the first routing subregion and the first connecting route. Sampling points are selected along the first routing region, and for each sampling point a set of operating values associated with the sampling point is calculated. A position for the parent node is selected based on the operating values for the sampling points.

Abstract: Compositions and methods for using nucleosome interacting protein domains to increase accessibility of programmable DNA modification proteins to target chromosomal sequences, thereby increasing efficiency of targeted genome/epigenetic modification in eukaryotic cells.

Abstract: The present invention relates to novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, to compositions containing them and to their use in the treatment of or prevention of diseases characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

Abstract: The present invention relates to novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, to compositions containing them and to their use in the treatment of or prevention of diseases characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

Abstract: The present invention relates to novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, to compositions containing them and to their use in the treatment of or prevention of diseases characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

Abstract: The present invention relates to novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, to compositions containing them and to their use in the treatment of or prevention of diseases characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

Abstract: The present invention relates to novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, to compositions containing them and to their use in the treatment of or prevention of diseases characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

Abstract: Disclosed herein is a method of treating a subject infected with hepatitis C virus, said method comprising administering to the subject for a time period an effective amount of sofosbuvir, an effective amount of ribavirin and an effective amount of ledipasvir. In one aspect, the method comprises administering to the subject an interferon-free treatment regimen comprising an effective amount of sofosbuvir, an effective amount of ribavirin and an effective amount of ledipasvir. In a particular aspect, the method is sufficient to produce an undetectable amount of HCV RNA in the subject for at least 12 weeks after the end of the time period.

Abstract: Provide an image processing apparatus and an image processing method which can generate an image having a high quality and a small data quantity. An image processing apparatus according to an embodiment includes a dividing unit which calculates a threshold value based on a pixel value distribution in image data, and divides pixels into two classes based on the calculated threshold value, a purification unit which prepares purified image data obtained by changing the pixel belonging to one class divided by the dividing unit into a specific color, and a pseudo-gradation binarization unit which binarizes the purified image data through a pseudo-gradation method.

Abstract: A simulation apparatus and method is provided for simulating complex high speed interconnects for which closed forms of the S-parameter are incorporated. Differential transmission lines are represented in a causal manner analytically using the 4-port S-parameter without concerns of passivity and stability. Difficult discontinuities of interconnect such as differential vias are represented in closed form and the present invention allows those interconnects to be characterized by 4-port S-parameter measurements or simulation. A complete method of combining causal transmission line models with discontinuities in cascade is provided.

Abstract: Method and system that test device sensitivity according to whether the device passes or fails when subjected to a test signal. The device may be repeatedly subjected to test signal at varying operating parameters in order to assess pass-fail threshold at which the device transitions from operating properly/improperly to operating improperly/properly.

Abstract: The invention relates to a method for oxidizing methane, including passing a gaseous, methane-containing mixture over a catalyst, wherein a carrier with a substrate surface consists substantially of titanium dioxide with a combination of platinum and palladium thereon, in the presence of molecular oxygen, and to a catalyst suitable thereto.

Abstract: Method and system that test device sensitivity according to whether the device passes or fails when subjected to a test signal. The device may be repeatedly subjected to test signal at varying operating parameters in order to assess pass-fail threshold at which the device transitions from operating properly/improperly to operating improperly/properly.

Abstract: A method for making measurements using a vector network analyzer, and for multi-port S-parameter and T-parameter conversion includes a generalized T-matrix definition that facilitates the conversion between the S-parameters and the T-parameters for multi-port networks based on the well understood and mathematically simple 2-port relations. One contemplated approach generalizes all multi-port networks into two cases: balanced and unbalanced. Through careful selection of the T-matrix, the contemplated method extends 2-port symmetry to multi-port networks and provides an engineering implementable relationship between the S- and T-parameters for multi-port networks. This symmetry extension allows a practical means to cascade and de-embed such networks.

Abstract: The present invention relates to a via parasitics testing and extracting method for Gigabit multi-layered PCB boards. The method of the present invention is a unique test and extraction process that utilizes a TDR measurement and processes the output data therefrom externally. The testing aspect involves obtaining a TDR module waveform and obtaining a text file with output data, whereas the extraction aspect involves analysis of the data in the text file. This method can be used directly to ascertain a Gigabit via structure without the limitations that are imposed by the conventional methods discussed above, and has been theoretically proven to be highly accurate and much faster than any of the existing methods. The method of the present invention has the potential to be included as a built-in testing feature in high-speed TDR meters, and may also be used in order to design an optimized via.