Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5, R6 and R7 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Abstract: Various embodiments provide for layer assignment of a network of a circuit design based on a resistance or capacitance characteristic, such as a resistance/capacitance characteristic associated with a layer, a wire, or a via of the circuit design. In particular, various embodiments consider a resistance/capacitance characteristic of a layer, a wire, or a via of a circuit design to determine a set of layers for routing one or more networks of the circuit design, which can enable some embodiments to route the networks on the layers within a certain range that has very close resistance/capacitance (RC) characteristics, and can permit routing each network on layers having the smallest RC characteristic difference.

Abstract: The present invention relates to novel compounds of formula (I) or (II), wherein R1 to R6, R11 to R17 are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.

Abstract: Various embodiments described herein provide for track assignment of wires of a network of a circuit design by dynamic programming. In particular, various embodiments use a dynamic programming process to determine a set of breaking points for a routing wire of a global-routed and layer-assigned circuit design, and to determine track assignments for each of the sub-wires (sub-routes) formed by applying the set of selected breaking points to the routing wire. This results in a set of track-assigned sub-wires (or track-assigned sub-routes), which various embodiments can connect together to generate a connected set of track-assigned sub-wires that can be used in place of the routing wire.

Abstract: Disclosed are substituted fused pyrazoles, for example substituted indazoles, that inhibit LRRK2 kinase activity, pharmaceutical compositions containing them and their use in the treatment of Parkinson's disease.

Abstract: Aspects of the present disclosure address improved systems and methods for buffer insertion in an integrated circuit (IC) design using a cost function that accounts for edge spacing and stack via constraints associated with cells in the IC design. An integrated circuit (IC) design comprising a routing topology for a net is accessed. A set of candidate insertion locations along the routing topology are identified. A set of buffering candidates is generated based on the candidate insertion locations. A buffering candidate comprises a cell inserted at a candidate insertion location along the routing topology. A cost associated with the buffering candidate is determined based on a number of potential edge spacing conflicts and a number of stack vias associated with the cell. A buffering solution for the net is selected from the buffering candidate based on the cost associated with the buffering candidate.

Abstract: An air supply assembly for a refrigerator, includes: an air duct cover plate defining, together with a refrigerator liner, an air supply space and configured to isolate the air supply space from a storage space in a compartment of the refrigerator, and a centrifugal wind wheel arranged in the air supply space, and axially sucking air in and blowing the air out towards a peripheral side, wherein a plurality of air return ports are provided in the air duct cover plate to allow air in the storage space to enter the air supply space; and the centrifugal wind wheel abuts against an inner side of the air duct cover plate and is configured to suck air in from a rear side thereof, such that air entering the air supply space via the air return ports is sucked in from the rear side of the centrifugal wind wheel.

Abstract: Aspects of the present disclosure address improved systems and methods for rebuffering an integrated circuit (IC) design using a unified improvement scoring algorithm. A plurality of rebuffering candidates are generated based on an initial buffer tree in an integrated circuit (IC) design. A rebuffering candidate in the plurality of rebuffering candidates comprises a modified buffer tree based on the initial buffer tree. A buffering cost of each rebuffering candidate is determined. A reference buffer tree is selected from among the rebuffering candidates based on the buffering cost of each rebuffering candidate. An improvement score of each rebuffering candidate is determined based on the buffering cost of each rebuffering candidate relative to the reference buffer tree. A new buffer tree is selected from among the plurality of rebuffering candidates to replace the initial buffer tree based on the improvement score of each rebuffering candidate.

Abstract: Compositions and methods for using nucleosome interacting protein domains to increase accessibility of programmable DNA modification proteins to target chromosomal sequences, thereby increasing efficiency of targeted genome/epigenetic modification in eukaryotic cells.

Abstract: The present invention relates to novel compounds that inhibit LRRK2 kinase activity, to processes for their preparation, to compositions containing them and to their use in the treatment of or prevention of diseases associated with or characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

Abstract: Aspects of the present disclosure address improved systems and methods for layer assignment to improve timing in integrated circuit (IC) designs. An initial placement layout of a net of an IC design is accessed. A plurality of buffer insertion candidates is generated using multiple candidate buffer insertion points and multiple layer assignments from among multiple layers of the IC design. Timing characteristics of each buffer insertion candidate are determined, and timing improvements provided by each buffer insertion candidate are determined based on respective timing characteristics. A buffer insertion candidate is selected from the plurality of buffer insertion candidates based on the timing improvement provided by the buffer insertion candidate. A layout instance for the IC is generated based in part on the selected buffer insertion candidate.

Abstract: Provided are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases associated with or characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

Abstract: Various embodiments provide for circuit design routing using a track assignment based on a plurality of panels (also referred to herein as a multi-panel track assignment). According to some embodiments, a track assignment of a wire within a particular panel is performed based on a primary panel bound or limit and a secondary panel bound or limit. For instance, during a track assignment for a particular wire falling within a particular panel, an embodiment can first attempt to assign the particular wire to a track that falls within panels within the primary panel bound and, if deemed not possible (e.g., due to a DRC, violation or congestion issue), the embodiment can then assign the particular wire to a track that falls within panels within the secondary panel bound.

Abstract: Compositions and methods for using nucleosome interacting protein domains to increase accessibility of programmable DNA modification proteins to target chromosomal sequences, thereby increasing efficiency of targeted genome/epigenetic modification in eukaryotic cells.

Abstract: Various embodiments provide for circuit design routing based on parallel run length (PRL) rules. In particular, a plurality of PRL rules is accessed and used to generate a set of additional routing blockages around an existing routing blockage of the circuit design. The additional routing blockages can be positioned relative to the existing routing blockage. During routing, the set of additional routing blockages can be modeled into a capacity map, which is then used by global to generate routing guide(s) between at least two nodes of the circuit design. In doing so, the various embodiments can assist in routing a wire while avoiding violation of the plurality of PRL rules with respect to the existing blockage, can speed up performance of global routing, can make it easier for detailed routing to honor routing guides produced by global routing, and can speed up performance of detailed routing in resolving DRC violations.

Abstract: The present invention relates to novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, to compositions containing them and to their use in the treatment of or prevention of diseases characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

Abstract: Compositions and methods for using nucleosome interacting protein domains to increase accessibility of programmable DNA modification proteins to target chromosomal sequences, thereby increasing efficiency of targeted genome/epigenetic modification in eukaryotic cells.

Abstract: Disclosed are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

Abstract: Systems, methods, media, and other such embodiments are described for routing track assignment in a circuit design. One embodiment involves accessing routing data for a circuit design, and a first wire of a plurality of wires in the routing data. A second wire is identified that is related to the first wire as a parent wire along a shared routing direction. A misalignment value is calculated for the first wire and the second wire, and a new routing placement is selected for the first wire based at least in part on the misalignment value. In some embodiments, all wires in various routings of a circuit design are checked for possible misalignment in order to improve slew performance via reduction of unnecessary vias.