Publication number: 20250145635
Abstract: A compound containing a bis(azanylylidene) sulfonyl structure of formula (I) as a PKR agonist and/or USP9X inhibitor, which can be used for treating related diseases mediated and regulated by PKR and USP9X, wherein the related diseases comprise, but are not limited to: sickle-cell anemia, ?-thalassemia, hereditary non-spherocytic hemolytic anemia, hemolytic anemia, hereditary spherocytosis, hereditary elliptocytosis, abetalipoproteinemia, paroxysmal nocturnal hemoglobinuria, acquired hemolytic anemia, congenital anemia, anemia of chronic diseases, colorectal cancer, kidney cancer, pancreatic cancer, breast cancer, lung cancer, esophageal cancer, melanoma, lymphoma, glioblastoma, or multiple myeloma.
Type:
Application
Filed:
December 21, 2022
Publication date:
May 8, 2025
Inventors:
Jianzong LI, Zao WANG, Shunchun ZHAO, TAO SHAO, Ruijie ZHOU, Jing WANG, Xiao HU, Yeye WANG, Xiaodong ZHANG, Jun TANG, Yuanqing TANG