Abstract: The invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially KRAS G12C inhibitors. The present invention provides a direct enantioselective chemical manufacturing method of making Compound A, or a pharmaceutically acceptable hydrate or solvent thereof: (I). The invention provides a process for preparing Intermediate B6* comprising reacting Intermediate B4* with Intermediate B5* in an atroposelective coupling reaction, using a chiral catalyst.

Abstract: Disclosed are methods and apparatuses for sidelink (SL) positioning measurement and reporting. An embodiment of the subject application provides a first user equipment (UE). The first UE includes: a processor configured to perform a positioning measurement procedure to obtain location information associated with the first UE based on SL positioning reference signal transmission(s) between the first UE and a set of second UEs; and a transmitter coupled with the processor and configured to transmit a first report to a network entity based on the positioning measurement procedure.

Abstract: A display panel and display apparatus, display panel includes an array substrate. Array substrate includes substrate and has display region. Display region includes color filter, pixel electrode, and first transistor that are located on same side of substrate. First transistor includes first semiconductor layer. Along direction perpendicular to plane of substrate, color filter is located between first semiconductor layer and pixel electrode, and first semiconductor layer is electrically connected to pixel electrode through first connecting portion. First connecting portion includes first connecting sub-portion in first connecting hole. Orthographic projection of first connecting sub-portion on plane of substrate does not overlap with orthographic projection of color filter on plane of substrate. Along direction parallel to plane of substrate, first connecting sub-portion at least partially overlaps with color filter.

Abstract: The present invention provides compositions and methods of treating and improving the symptoms of IgG4-RD using an antibody or antigen-binding fragment thereof that specifically binds human CD19.

Abstract: The present invention relates to the technical field of wastewater treatment, and discloses a bioaugmentation treatment process for lithium battery producing wastewater. The method comprises the following steps: 1) introducing wastewater into a hydrolytic acidification tank, and adding Enterobacter sp. NJUST50 and activated sludge to the hydrolytic acidification tank for hydrolytic acidification treatment; 2) introducing the effluent into an anoxic tank, and adding Enterobacter sp. NJUST50 and anaerobic activated sludge for anoxic treatment; 3) introducing the effluent into an aerobic tank, and adding Enterobacter sp. NJUST50 and aerobic activated sludge for aerobic treatment; 4) introducing the effluent into an anoxic filter tank, and adding Enterobacter sp. NJUST50 and anaerobic activated sludge to the filter tank for treatment; and 5) introducing the effluent into a biological aerated filter tank, and adding a sludge mixture of Enterobacter sp.

Abstract: A preparation method and application of spindle-shaped W@CuO material with adjustable included angle includes the steps of: preparing a copper source solution and adding to a mixture of anionic surfactant and n-butanol; adding a tungsten source solution and dripping an alkali solution, then carrying out hydrothermal reaction, centrifugation, washing and drying. By controlling the growth rate of the high-energy surface at the water-oil interface with the salt concentration, surfactant concentration, supersaturation of water and n-butanol solutions, the monodispersed spindle-shaped structure with unique microstructure and an included angle of 27-74° can be prepared. The surface of W@CuO materials with different included angles shows different electric field strengths, which can effectively modulate the charge transfer during the catalytic process and improve the catalytic reaction activity.

Abstract: Disclosed is a fully immersed energy storage device, which includes a casing and a water pump. An insulation box is mounted inside the casing, and the insulation box is assembled with an assembly plate thereon. A mounting platform is mounted on the assembly plate and assembled with an annular rack. A rotating groove is provided between the mounting platform and the annular rack. Balls are placed in the rotating groove. The mounting platform is assembled with an assembly block, on which a rotating shaft is mounted. One end of the rotating shaft connects to a gear. The other end of the rotating shaft connects to a first assembly rod, to which a second assembly rod is connected. The second assembly rod connects to a fixed block, which is connected to an energy storage box. A motor base is mounted on the casing. A motor is mounted on the motor base.

Abstract: A touch substrate (01) and a touch display device. The touch substrate (01) includes: a base substrate (101); a plurality of first touch electrodes (102) located on the base substrate (101); a plurality of second touch electrodes (103) located on a side, facing away from the base substrate (101), of a layer where the first touch electrodes (102) are located and insulated from the first touch electrodes (102); and a plurality of floating electrodes (104) insulated from the plurality of first touch electrodes (102) and the plurality of second touch electrodes (103), and arranged on the same layer as at least one of the first touch electrodes (102) or the second touch electrodes (103). Each floating electrode (104) has a grid shape, and at least part of the floating electrodes (104) is disconnected at at least part of dots.

Abstract: Disclosed herein are macrocyclic compounds that inhibit the binding of KRas. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the KRas inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia, lung cancer, colorectal cancer, pancreatic cancer, and other diseases or conditions dependent on KRas interaction.

Abstract: The present invention provides a capsule endoscope, including: a power supply component; a power utilization component, comprising an image acquisition component; at least one power storage component, which is connected in parallel with the power supply component to form a power pack, the power storage component and the power supply component jointly providing power for the image acquisition component. According to the capsule endoscope, a capacitor, the power supply component and the like work in conjunction to supply power to a power utilization component, so that a peak power supply quantity can be increased, and the power utilization requirement can be met even if a high-power-consumption power utilization component operates. A multi-capacitor parallel connection mode is used in more than one power pack, so that the overlarge size of a single capacitor and possible safety risks can be avoided, and power distribution can be achieved.

Abstract: The present application relates to a silicone oil-based immersion coolant for an electronic component. The silicone oil-based immersion coolant for an electronic component includes a base oil and an additive. The base oil includes a low-viscosity silicone oil. The additive includes a silicone oil diluent and a thermally conductive inorganic filler. The viscosity of the low-viscosity silicone oil is less than or equal to 1000 cSt. The thermally conductive inorganic filler is an insulating filler. Based on the mass of the immersion coolant, a mass percentage content of the base oil is in a range from 70% to 85%, a mass percentage content of the silicone oil diluent is in a range from 10% to 20%, and a mass percentage content of the thermally conductive inorganic filler is in a range from 5% to 10%.

Abstract: A semiconductor structure includes a first active region, a second active region and a dielectric wall. The second active region is disposed adjacent to the first active region, wherein there is a space between the first active region and the second active region. The dielectric wall is formed within the space between the first active region and the second active region. The dielectric wall has a first wall width and a second wall width different from the first wall width.

Abstract: A remote control system and a remote control method for a magnetic capsule endoscope are provided. The remote control system includes a console and a computing terminal device. The console includes a base and one or more joysticks installed on the base, where the joysticks generate a first electrical signal according to a shaking operation. The computing terminal device converts the first electrical signal to a first control instruction and sends the first control instruction to an industrial personal computer of a controlled device through a telecommunication connection. The first control instruction instructs a drive mechanism of the controlled device to drive a magnetic moving component of the controlled device to perform a first motion. The magnetic moving component controls the movement of the magnetic capsule endoscope through a magnetic field of the controlled device when the first motion is performed.

Abstract: The present invention discloses a capsule endoscope, which comprises an enclosure, and an imaging unit, a data processing unit and an antenna unit arranged in the enclosure. The enclosure comprises a cylindrical middle enclosure and two hemispherical covers connected to both ends of the middle enclosure, and the antenna unit is arranged close to the inner surface of the middle enclosure. The antenna unit is arranged close to the inner surface of the middle enclosure. Such arrangement can save internal space and improve the space utilization, and also, the arrangement of the antenna unit does not affect the layout of the imaging unit.

Abstract: The present application provides a touch substrate, a design structure of a touch electrode layer, a display panel, and a display device. The design structure of the touch electrode layer includes connecting portions and conducting wires. The connecting portions and the conducting wires form a plurality of meshes. One connecting portion is connected with four conducting wires. In conducting wires connected with a same connecting portion, at least one side edge of an end portion of at least one conducting wire connected with the connecting portion is provided with a depression, and a bottom edge of the depression joins an edge of the connecting portion. The touch electrode layer is prepared according to the design structure. The display panel includes the touch electrode layer. The display device includes the display panel.

Abstract: Examples of the present application provide operation methods of memories, memory devices and systems. In an example, an operation method includes: in response to a first defective memory cell row of a plurality of memory cell rows in the memory being repaired before packaging, invalidating, in a post-package repair mode, a first repair strategy for repairing the first defective memory cell row before packaging, and configuring a second repair strategy for repairing the first defective memory cell row and storing the second repair strategy.

Abstract: Disclosed are a separator and a battery including the same. An adhesive layer of the separator includes a composite material with a fibrous core-shell structure. In the composite material with a fibrous core-shell structure, the nitrogen-containing phosphate compound is encapsulated in a vinylidene fluoride polymer. When the battery is used at room temperature, the encapsulation structure is stable, the nitrogen-containing phosphate compound is encapsulated in the vinylidene fluoride polymer and stably exists in the separator, without affecting the electrical performance of the battery. In addition, the fibrous vinylidene fluoride polymer can perform excellent at bonding, and tightly bonds the separator to the positive electrode plate and negative electrode plate together, ensuring that the battery does not deform during the cycle. The battery can effectively improve the safety performance while taking into account performance of the battery at high and low temperatures.

Abstract: Disclosed are a high-throughput preparation device for metal fiber based on multi powder and a method for preparing a metal fiber using the device. The high-throughput preparation device includes a metal powder conveying system, a metal powder mixing system, a metal powder melting system and a metal fiber forming system which are connected in sequence, where the metal powder melting system includes an induction powder melting device and a laser powder melting device which are independently disposed. The method for preparing a metal fiber using the high-throughput preparation device includes four steps: powder conveying, powder mixing, melting and forming.

Abstract: Apparatus and methods of Channel Status Information (CSI) acquisition on sidelink are disclosed. The apparatus includes: a transmitter that transmits a reference signal to a device on a sidelink (SL) transmission; a receiver that receives a channel quality report from the device; and a processor that controls the transmitter and the receiver, and decodes the channel quality report to obtain a channel quality; wherein the processor is configurable to support one or a combination selected from a group consisting of: a reporting activation scheme where an SL Channel Status Information (CSI) reporting activation indicator is configured; and a measurement triggering scheme where the transmitter initiates transmission of the reference signal upon satisfying a triggering condition.