Patents by Inventor Xuan Zhao

Xuan Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10685112
    Abstract: In some implementations there may be provided a system. The system may include a processor and a memory. The memory may include program code which causes operations when executed by the processor. The operations may include analyzing a series of events contained in received data. The series of events may include events that occur during the execution of a data object. The series of events may be analyzed to at least extract, from the series of events, subsequences of events. A machine learning model may determine a classification for the received data. The machine learning model may classify the received data based at least on whether the subsequences of events are malicious. The classification indicative of whether the received data is malicious may be provided. Related methods and articles of manufacture, including computer program products, are also disclosed.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: June 16, 2020
    Assignee: Cylance Inc.
    Inventors: Xuan Zhao, Aditya Kapoor, Matthew Wolff, Andrew Davis, Derek Soeder, Ryan Permeh
  • Publication number: 20200181668
    Abstract: A method for preparing troxerutin ester using whole-cell catalysis belongs to the fields of biological catalysis and pharmaceutical chemistry. The method specifically includes the following steps: evenly mixing troxerutin and a mixed organic solvent containing pyridine, then adding an acyl donor and a whole-cell catalyst, and performing a reaction under oscillation at a reaction temperature of 25° C. to 55° C.; and after the reaction is finished, separating and purifying a product by column chromatography or thin-layer chromatography, so as to obtain the troxerutin ester. The invention has the advantages of mild reaction conditions, environmental friendliness, simple process, fewer side reactions and high selectivity.
    Type: Application
    Filed: November 30, 2017
    Publication date: June 11, 2020
    Applicant: SOUTH CHINA UNIVERSITY OF TECHNOLOGY
    Inventors: Xiaofeng LI, Xuan XIN, Guanglei ZHAO
  • Publication number: 20200147262
    Abstract: The present invention discloses polyglycol epoxide crosslinked sodium hyaluronate gel for injection and a preparation method thereof. A polyglycol epoxide is a compound with single molecular weight preferably; a plurality of ether bonds are present in the molecule of the polyglycol epoxide, the water solubility is good, and thus, the polyglycol epoxide is more easily subjected to a crosslinking reaction with polysaccharides; and meanwhile, polyglycol is relatively easy in adjustment of the number of repeating units and relatively easy in control of length, and thus, the sodium hyaluronate gel prepared by taking the polyglycol epoxide as a crosslinker is relatively easy in regulation and control of properties. The crosslinked sodium hyaluronate gel is low in toxicity, little in residual, small in squeezing and pushing force, good in shaping performance, good in enzyme resistance and long in in-vivo retention time. The present invention further discloses a mild crosslinker deactivation technology.
    Type: Application
    Filed: December 26, 2017
    Publication date: May 14, 2020
    Applicant: JENKEM TECHNOLOGY CO., LTD. (BEIJING)
    Inventors: Zhen WEI, Meina LIN, Xuan ZHAO
  • Publication number: 20200147228
    Abstract: The invention discloses use of a conjugate of polyethylene glycol and a local anesthetic in non-anesthetic analgesia. A local anesthetic is prepared into a prodrug or a sustained release preparation, wherein a high molecular polymer such as polyethylene glycol in the prodrug is covalently bonded with a local anesthetic, and auxiliary materials with a sustained release effect in the sustained release preparation are non-covalently bonded to the local anesthetic. After administration, there is no anesthesia and analgesic effect before the release of the free local anesthetic. After the free local anesthetic is released, an analgesic effect is achieved.
    Type: Application
    Filed: December 22, 2017
    Publication date: May 14, 2020
    Applicant: JENKEM TECHNOLOGY CO., LTD. (TIANJIN)
    Inventors: Zewang FENG, Jinliang WANG, Yanli XIONG, Juan SHI, Xuan ZHAO
  • Publication number: 20200140611
    Abstract: The disclosure provides a multi-arm multi-claw polyethylene glycol derivative suitable for click chemistry reactions of general formula I, wherein R is a polyethylene glycol residue having a linear-chain structure, a Y-type structure or a multi-branched structure, R1, R2 and R3 are linking groups, P is an terminal group of non-azido non-alkynyl group, D is —N3 or —C?CH, l is selected from an integer of 1 to 20, and m is selected from an integer of 0 to 19.
    Type: Application
    Filed: December 30, 2019
    Publication date: May 7, 2020
    Inventors: YANLI XIONG, JINLIANG WANG, ZEWANG FENG, LIHUI ZHENG, XUAN ZHAO
  • Publication number: 20200131147
    Abstract: The present invention discloses a PEGylated thioxanthone photoinitiator and a photosensitive resin composition, the PEGylated thioxanthone compound is eco-friendly and has low toxicity, high initiation efficiency and good thermal stability, meanwhile, as a kind of photoinitiator, the compound has a small amount of fragment residue after cured, and may improve the compatibility of the photoinitiator and photosensitive resin composition system. The photosensitive resin composition provided by the present invention has reasonable allocation of ingredients and content in the components thereof, capable of 3D-printing a hydrogel having a specific structure; the hydrogel has lower cytotoxicity and better biocompatibility, and may applied in bioengineering fields, e.g., 3D cell culture.
    Type: Application
    Filed: December 30, 2019
    Publication date: April 30, 2020
    Inventors: HUI ZHU, MEINA LIN, XUAN ZHAO
  • Publication number: 20200129542
    Abstract: The present invention discloses a branched polyethylene glycol epoxy derivative crosslinked sodium hyaluronate gel, preparation and application thereof. The crosslinking agent used in the crosslinked sodium hyaluronate gel prepared by the present invention is a polyethylene glycol epoxy derivative, due to the existence of multiple ether bonds in the molecule of the crosslinking agent, there are more hydrogen bonds in the gel system; meanwhile, due to the particularity of the space structure of the branched polyethylene glycol epoxy derivative, the gel prepared has a more complex winding structure in its space, thus achieving better stability. Moreover, the branched polyethylene glycol epoxy derivative involved in the present invention is a compound with single molecular weight, therefore, the gel prepared thereby has better batch stability.
    Type: Application
    Filed: December 30, 2019
    Publication date: April 30, 2020
    Inventors: ZHEN WEI, MEINA LIN, XUAN ZHAO
  • Publication number: 20200131107
    Abstract: The disclosure discloses a dendritic polyethylene glycol derivative and a preparation method and an application thereof. The dendritic polyethylene glycol derivative has a structure of formula (I), has multiple end functional groups, has a stronger water solubility in comparison with linear-chain polyethylene glycol, and can solve a problem of insufficient water solubility due to the increase of load when modifying an insoluble drug by the polyethylene glycol. The preparation method of the dendritic polyethylene glycol derivative provided by the disclosure has mild reaction conditions, is green and environmentally friendly, is low in cost, and is easy to implement industrialization.
    Type: Application
    Filed: December 30, 2019
    Publication date: April 30, 2020
    Inventors: HUI ZHU, MEINA LIN, XUAN ZHAO
  • Publication number: 20200131109
    Abstract: Being used for drug modification, the multi-arm single molecular weight polyethylene glycol and an active derivative thereof provided herein can effectively improve the solubility, stability, and immunogenicity of the drugs, improve the absorption of the drugs in vivo, prolong the half-life of the drugs, and increase bioavailability, enhance efficacy, and reduce toxic and side effects of the drugs. A gel formed from the active derivative of the multi-arm single molecular weight polyethylene glycol provided herein can be used for the preparation of controlled release drugs so as to prolong the action time of the drugs, thereby reducing the number of administrations and improving patient compliance.
    Type: Application
    Filed: December 30, 2019
    Publication date: April 30, 2020
    Inventors: ZHEN WEI, MEINA LIN, XUAN ZHAO
  • Patent number: 10637874
    Abstract: In one respect, there is provided a system for training a machine learning model to detect malicious container files. The system may include at least one processor and at least one memory. The memory may include program code which when executed by the at least one processor provides operations including: processing a container file with a trained machine learning model, wherein the trained machine learning is trained to determine a classification for the container file indicative of whether the container file includes at least one file rendering the container file malicious; and providing, as an output by the trained machine learning model, an indication of whether the container file includes the at least one file rendering the container file malicious. Related methods and articles of manufacture, including computer program products, are also disclosed.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: April 28, 2020
    Assignee: Cylance Inc.
    Inventors: Xuan Zhao, Matthew Wolff, John Brock, Brian Wallace, Andrew Wortman, Jian Luan, Mahdi Azarafrooz, Andrew Davis, Michael Wojnowicz, Derek Soeder, David Beveridge, Yaroslav Oliinyk, Ryan Permeh
  • Patent number: 10626944
    Abstract: The present disclosure discloses an actuator, comprising a first torsion spring body and a second torsion spring body, each of the first torsion spring body and the second torsion spring body comprising: an inner ring; an outer ring; and a plurality of elastic units, connected in parallel between the inner ring and the outer ring. An outer ring of the first torsion spring body and an outer ring of the second torsion spring body are rigidly connected, and an inner ring of the first torsion spring body and an inner ring of the second torsion spring body are aligned with each other. The actuator further includes a motor element and a braking element. The motor element is for providing an output torque, and is connected with the inner ring of the first torsion spring body. The braking element is for providing a braking torque, and is connected with the inner ring of the second torsion spring body.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: April 21, 2020
    Assignee: The Chinese University of Hong Kong
    Inventors: Wei-Hsin Liao, Bing Chen, Ling Qin, Xuan Zhao, Hao Ma
  • Patent number: 10596268
    Abstract: The present invention relates to the technical field of medicine, in particular to a conjugate of dezocine and polyethylene glycol and a pharmaceutical composition thereof. The conjugate of dezocine and water-soluble oligomer provided by the present invention has better pharmacokinetic properties and a high drug absorption degree, may reduce the side effects of the drug, and achieve a smaller administration dosage and a more diverse mode of administration, such as oral administration, in clinic. Compared with dezocine, the conjugate of the present invention has a stronger analgesic effect and a longer analgesic duration, may reduce the frequency of drug administration, improve patient compliance, and has advantages in effectiveness and safety of the drug, as well as drug tolerance, etc.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: March 24, 2020
    Assignee: JENKEM TECHNOLOGY CO., LTD. (BEIJING)
    Inventors: Zewang Feng, Jinliang Wang, Yanli Xiong, Xuan Zhao
  • Publication number: 20200090407
    Abstract: An augmented reality viewing system is described. A local coordinate frame of local content is transformed to a world coordinate frame. A further transformation is made to a head coordinate frame and a further transformation is made to a camera coordinate frame that includes all pupil positions of an eye. One or more users may interact in separate sessions with a viewing system. If a canonical map is available, the earlier map is downloaded onto a viewing device of a user. The viewing device then generates another map and localizes the subsequent map to the canonical map.
    Type: Application
    Filed: August 12, 2019
    Publication date: March 19, 2020
    Applicant: Magic Leap, Inc.
    Inventors: Jeremy Dwayne Miranda, Rafael Domingos Torres, Daniel Olshansky, Anush Mohan, Robert Blake Taylor, Samuel A. Miller, Jehangir Tajik, Ashwin Swaminathan, Lomesh Agarwal, Ali Shahrokni, Prateek Singhal, Joel David Holder, Xuan Zhao, Siddharth Choudhary, Helder Toshiro Suzuki, Hiral Honar Barot, Eran Guendelman, Michael Harold Liebenow
  • Patent number: 10572195
    Abstract: An image forming system and an image forming method for parsing instant messaging information are provided. The system includes a receiver for receiving instant messaging information, a parser for determining a data type of the instant messaging information, a processor for processing the instant messaging information based on the determined data type and converting the instant messaging information into image information recognizable and printable by the image forming device, and an imager for controlling the image forming device to print the image information. The processor includes an imbedded browser, and when the data type is website link, the embedded browser acquires related content corresponding to the link, the processor converts the related content into image information recognizable and printable by the image forming device. The image information is sent to the imager.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: February 25, 2020
    Assignee: ZHUHAI SEINE TECHNOLOGY CO., LTD.
    Inventors: Xuan Tan, Wei Zhao
  • Publication number: 20200057853
    Abstract: In one respect, there is provided a system for training a machine learning model to detect malicious container files. The system may include at least one processor and at least one memory. The at least one memory may include program code that provides operations when executed by the at least one processor. The operations may include: training, based on a training data, a machine learning model to enable the machine learning model to determine whether at least one container file includes at least one file rendering the at least one container file malicious; and providing the trained machine learning model to enable the determination of whether the at least one container file includes at least one file rendering the at least one container file malicious. Related methods and articles of manufacture, including computer program products, are also disclosed.
    Type: Application
    Filed: October 24, 2019
    Publication date: February 20, 2020
    Inventors: Xuan Zhao, Matthew Wolff, John Brock, Brian Wallace, Andy Wortman, Jian Luan, Mahdi Azarafrooz, Andrew Davis, Michael Wojnowicz, Derek Soeder, David Beveridge, Yaroslav Oliinyk, Ryan Permeh
  • Publication number: 20200046842
    Abstract: The present invention provides a multi-drug-loading site and high drug-loading capacity ligand-drug conjugate. The ligand-drug conjugate has a structure of general formula (I). The ligand-drug conjugate has the characteristics of high loading capacity, high drug efficacy, low toxicity, and low risks. The ligand-drug conjugate can be used particularly to connect to a low toxicity chemical molecule, thereby extending a therapeutic window. Furthermore, the present invention provides an antibody-drug conjugate molecule. The antibody-drug conjugate molecule has the characteristics of multiple drug-loading ability and high drug-loading capacity, such that the antibody-drug conjugate can carry a large amount of a low toxicity chemical molecule and achieve a therapeutic effect without depending on antibody targeting or high toxicity chemicals.
    Type: Application
    Filed: September 30, 2019
    Publication date: February 13, 2020
    Inventors: Yanping SONG, Jinghui DU, Leimin WANG, Jinliang WANG, Meina LIN, Zewang FENG, Xuan ZHAO
  • Publication number: 20200048412
    Abstract: The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core molecule through heteroatom linkages. The branched polymers bear at least one functional group for reacting with a biologically active agent to form a biologically active conjugate. The functional group of the branched polymer can be directly attached to the aliphatic hydrocarbon core or via an intervening linkage, such as a heteroatom, -alkylene-, —O-alkylene-O—, -alkylene-O-alkylene-, -aryl-O—, —O-aryl-, (—O-alkylene-)m, or (-alkylene-O—)m linkage, wherein m is 1-10.
    Type: Application
    Filed: October 1, 2019
    Publication date: February 13, 2020
    Inventors: Michael D. Bentley, Xuan Zhao, Xiaoming Shen, William D. Battle, III
  • Publication number: 20200051328
    Abstract: A cross reality system that provides an immersive user experience by storing persistent spatial information about the physical world that one or multiple user devices can access to determine position within the physical world and that applications can access to specify the position of virtual objects within the physical world. Persistent spatial information enables users to have a shared virtual, as well as physical, experience when interacting with the cross reality system. Further, persistent spatial information may be used in maps of the physical world, enabling one or multiple devices to access and localize into previously stored maps, reducing the need to map a physical space before using the cross reality system in it. Persistent spatial information may be stored as persistent coordinate frames, which may include a transformation relative to a reference orientation and information derived from images in a location corresponding to the persistent coordinate frame.
    Type: Application
    Filed: October 4, 2019
    Publication date: February 13, 2020
    Applicant: Magic Leap, Inc.
    Inventors: Anush Mohan, Rafael Domingos Torres, Daniel Olshansky, Samuel A. Miller, Jehangir Tajik, Joel David Holder, Jeremy Dwayne Miranda, Robert Blake Taylor, Ashwin Swaminathan, Lomesh Agarwal, Hiral Honar Barot, Helder Toshiro Suzuki, Ali Shahrokni, Eran Guendelman, Prateek Singhal, Xuan Zhao, Siddharth Choudhary, Nick Kramer, Ken Tossell
  • Publication number: 20200040682
    Abstract: The present invention discloses a method for lowering an oil pipe in a gas well without well-killing, a soluble bridge plug and a material preparation method thereof, wherein, the method comprises the steps of: lowering a bridge plug in a wellbore such that the bridge plug blocks the wellbore at a predetermined location in the wellbore; injecting water in the wellbore after the pressure in the wellbore has been relieved so as to replace gases in the wellbore; and lowering an oil pipe in the wellbore to the location of the bridge plug. The method for lowering an oil pipe in a gas well without well-killing, the soluble bridge plug and the material preparation method thereof provided in the present invention successfully solve the problem of high cost for lowering an oil pipe under pressure after a fracturing fluid has been injected into the casing.
    Type: Application
    Filed: April 4, 2018
    Publication date: February 6, 2020
    Inventors: Xianwen Li, Qiaorong Han, Yanming Zhang, Xu Ma, Zhanguo Ma, Yangming Hu, Changjing Zhou, Yuanxiang Xiao, Huaqiang Shi, Baochun Chen, Yonghong Gu, Xiaoyong Wen, Xuan'ang Lai, Yong Ding, Liang Ye, Qianyun Zhao, Xinxing Ma, Yajuan Wang, Man Bi, Hua Shi, Mingfang He, Xiaorui Liu, Wei Gao, Hongying Li, Yun Ling, Ruifen Hao, Lei Shen, Guohui Su, Shaowei Zhou, Shusheng Li, Zhe Li
  • Publication number: 20200034624
    Abstract: An apparatus configured to be worn on a head of a user, includes: a screen configured to present graphics to the user; a camera system configured to view an environment in which the user is located; and a processing unit configured to determine a map based at least in part on output(s) from the camera system, wherein the map is configured for use by the processing unit to localize the user with respect to the environment; wherein the processing unit of the apparatus is also configured to obtain a metric indicating a likelihood of success to localize the user using the map, and wherein the processing unit is configured to obtain the metric by computing the metric or by receiving the metric.
    Type: Application
    Filed: July 24, 2019
    Publication date: January 30, 2020
    Applicant: MAGIC LEAP, INC.
    Inventors: Divya SHARMA, Ali SHAHROKNI, Anush MOHAN, Prateek SINGHAL, Xuan ZHAO, Sergiu SIMA, Benjamin LANGMANN