Patents by Inventor Xuan Zhao

Xuan Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170368191
    Abstract: Provided are polyethylene glycol drug conjugates of general formula (I), (II) or (III) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules. The conjugates can interact with receptor dimers or polymers, thereby improving the in vivo distribution of the drug, changing the oil and water distribution coefficient, enhancing the pharmacological activity, reducing the blood-brain barrier permeability of the drug, and improving the bioavailability of the drug.
    Type: Application
    Filed: September 8, 2017
    Publication date: December 28, 2017
    Inventors: Lihua XU, Xuan ZHAO, Zewang FENG, Jinliang WANG, Zhen'guo WANG
  • Patent number: 9834530
    Abstract: Disclosed are a 3-furyl-2-cyano-2-acrylamide derivative with epidermal growth factor receptor (EGFR) inhibitory activity and pharmaceutical acceptable salt thereof, together with preparation method thereof, pharmaceutical composition comprising the compound, and application of the compound in treating senile dementia (AD). The new compound is shown as formula I, wherein R1 is selected from the group consisting of H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl and C3-C6 cycloalkyl; R2 is selected from the group consisting of alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, aralkyl and heteroaralkyl; X is selected from the group consisting of CH2, NH, O and S; m and n are all integers greater than or equal to zero.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: December 5, 2017
    Assignee: Jenkem Technology Co., Ltd. (Beijing)
    Inventors: Zewang Feng, Jianhuan Jia, Yan Liu, Zhenguo Wang, Xuan Zhao
  • Patent number: 9808533
    Abstract: Provided herein are water-soluble prodrugs, compositions comprising such prodrugs, and related methods of making and administering the same. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are typically covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water-soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: November 7, 2017
    Assignee: Nektar Therapeutics
    Inventors: Xuan Zhao, Michael David Bentley, Zhongxu Ren, Tacey X. Viegas
  • Patent number: 9789198
    Abstract: Provided are polyethylene glycol drug conjugates of general formula (I), (II) or (III) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules. The conjugates can interact with receptor dimers or polymers, thereby improving the in vivo distribution of the drug, changing the oil and water distribution coefficient, enhancing the pharmacological activity, reducing the blood-brain barrier permeability of the drug, and improving the bioavailability of the drug.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: October 17, 2017
    Assignee: JENKEM TECHNOLOGY CO., LTD. (TIANJIN)
    Inventors: Lihua Xu, Xuan Zhao, Zewang Feng, Jinliang Wang, Zhenguo Wang
  • Patent number: 9781150
    Abstract: Data is received that includes a plurality of samples that each characterize interception of data traffic to a computing device over a network. Thereafter, the plurality of samples characterizing the interception of data traffic are grouped into a plurality of clusters. At least a portion of the samples are labeled to characterize a likelihood of each such sample as relating to an unauthorized interception of data traffic. Each cluster is assigned with a label corresponding to a majority of samples within such cluster. At least one machine learning model is trained using the assigned labeled clusters such that, once trained, the at least one machine learning model determines a likelihood of future samples as relating to an unauthorized interception of data traffic to a corresponding computing device.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: October 3, 2017
    Assignee: Cylance Inc.
    Inventors: Xuan Zhao, Brian Michael Wallace
  • Publication number: 20170266305
    Abstract: A pharmaceutical composition of a polyethylene glycol-modified camptothecin derivative and a preparation method thereof. The pharmaceutical composition is prepared mainly from following components: a camptothecin derivative modified by polyethylene glycol, a pH value adjustment agent and water for injection. The pharmaceutical composition has high stability.
    Type: Application
    Filed: June 2, 2017
    Publication date: September 21, 2017
    Inventors: Zewang FENG, Wen LI, Zhenguo WANG, Xuan ZHAO
  • Patent number: 9762611
    Abstract: A first node of a networked computing environment initiates each of a plurality of different types of man-in-the middle (MITM) detection tests to determine whether communications between first and second nodes of a computing network are likely to have been subject to an interception or an attempted interception by a third node. Thereafter, it is determined, by the first node, that at least one of the tests indicate that the communications are likely to have been intercepted by a third node. Data is then provided, by the first node, data that characterizes the determination. In some cases, one or more of the MITM detection tests utilizes a machine learning model. Related apparatus, systems, techniques and articles are also described.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: September 12, 2017
    Assignee: Cylance Inc.
    Inventors: Brian Michael Wallace, Xuan Zhao, Jonathan Wesley Miller
  • Publication number: 20170249462
    Abstract: An endpoint computer system can harvest data relating to a plurality of events occurring within an operating environment of the endpoint computer system and can add the harvested data to a local data store maintained on the endpoint computer system. In some examples, the local data store can be an audit log and/or can include one or more tamper resistant features. Systems, methods, and computer program products are described.
    Type: Application
    Filed: November 18, 2016
    Publication date: August 31, 2017
    Inventors: Ryan Permeh, Matthew Wolff, Samuel Oswald, Xuan Zhao, Mark Culley, Steve Polson
  • Publication number: 20170249455
    Abstract: Determining, by a machine learning model in an isolated operating environment, whether a file is safe for processing by a primary operating environment. The file is provided, when the determining indicates the file is safe for processing, to the primary operating environment for processing by the primary operating environment. When the determining indicates the file is unsafe for processing, the file is prevented from being processed by the primary operating environment. The isolated operating environment can be maintained on an isolated computing system remote from a primary computing system maintaining the primary operating system. The isolating computing system and the primary operating system can communicate over a cloud network.
    Type: Application
    Filed: August 30, 2016
    Publication date: August 31, 2017
    Inventors: Ryan Permeh, Derek A. Soeder, Matthew Wolff, Ming Jin, Xuan Zhao
  • Publication number: 20170249459
    Abstract: In one aspect there is provided a method. The method may include: determining that an executable implements a sub-execution environment, the sub-execution environment being configured to receive an input, and the input triggering at least one event at the sub-execution environment; intercepting the event at the sub-execution environment; and applying a security policy to the intercepted event, the applying of the policy comprises blocking the event, when the event is determined to be a prohibited event. Systems and articles of manufacture, including computer program products, are also provided.
    Type: Application
    Filed: February 24, 2017
    Publication date: August 31, 2017
    Inventors: Ryan Permeh, Derek Soeder, Matthew Wolff, Ming Jin, Xuan Zhao
  • Publication number: 20170249461
    Abstract: An endpoint computer system can harvest data relating to a plurality of events occurring within an operating environment of the endpoint computer system and can add the harvested data to a local data store maintained on the endpoint computer system. A query response can be generated, for example by identifying and retrieving responsive data from the local data store. The responsive data are related to an artifact on the endpoint computer system and/or to an event of the plurality of events. In some examples, the local data store can be an audit log and/or can include one or more tamper resistant features. Systems, methods, and computer program products are described.
    Type: Application
    Filed: November 17, 2016
    Publication date: August 31, 2017
    Inventors: RYAN PERMEH, Matthew Wolff, Samuel Oswald, Xuan Zhao, Mark Culley, Steve Polson
  • Publication number: 20170241764
    Abstract: A wafer metrology system includes an interferometer sub-system and a controller. The interferometer sub-system is configured to generate an interferogram with an intensity map that corresponds to a modulated representation of a wafer surface. Further, the interferometer sub-system includes a detector configured to capture the interferogram. The controller includes one or more processors configured to generate a wrapped phase map of the interferogram, define patterns associated with features on the wafer, and correct phase discontinuities by applying a phase unwrapping procedure to the wrapped phase map to generate an unwrapped phase map and correcting phase discontinuities in the unwrapped phase map based on the patterns, or by combining phase unwrapping and correction in a unified step. Further, the patterns comprise two or more structures such that a portion of the unwrapped phase map associated with structures of the same type is continuous across borders separating structures of the same type.
    Type: Application
    Filed: December 28, 2015
    Publication date: August 24, 2017
    Inventors: Helen Liu, Xuan Zhao, Xiaowei Li
  • Publication number: 20170237773
    Abstract: A first node of a networked computing environment initiates each of a plurality of different types of man-in-the middle (MITM) detection tests to determine whether communications between first and second nodes of a computing network are likely to have been subject to an interception or an attempted interception by a third node. Thereafter, it is determined, by the first node, that at least one of the tests indicate that the communications are likely to have been intercepted by a third node. Data is then provided, by the first node, data that characterizes the determination. In some cases, one or more of the MITM detection tests utilizes a machine learning model. Related apparatus, systems, techniques and articles are also described.
    Type: Application
    Filed: December 15, 2016
    Publication date: August 17, 2017
    Inventors: Brian Michael Wallace, Xuan Zhao, Jonathan Wesley Miller
  • Patent number: 9718837
    Abstract: The present invention belongs to the field of medicinal technique, specifically relates to nitrogen-containing heterocyclic ring-substituted dihydroartemisinin derivatives and their optical isomers according to formula I or II; wherein substituent X, Y, R, R1, R2, R3 and R4 are as defined in the Description. The derivatives and compositions thereof can be prepared into clinically acceptable tablets, capsules, injections, ointments, etc., and thus have pharmaceutical uses in the treatment and/or prevention of cancers.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: August 1, 2017
    Assignee: Shenyang Pharmaceutical University
    Inventors: Linxiang Zhao, Dan Liu, Hang Zhong, Xuan Zhao, Yongkui Jing
  • Patent number: 9721097
    Abstract: As part of an analysis of the likelihood that a given input (e.g. a file, etc.) includes malicious code, a convolutional neural network can be used to review a sequence of chunks into which an input is divided to assess how best to navigate through the input and to classify parts of the input in a most optimal manner. At least some of the sequence of chunks can be further examined using a recurrent neural network in series with the convolutional neural network to determine how to progress through the sequence of chunks. A state of the at least some of the chunks examined using the recurrent neural network summarized to form an output indicative of the likelihood that the input includes malicious code. Methods, systems, and articles of manufacture are also described.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: August 1, 2017
    Assignee: Cylance Inc.
    Inventors: Andrew Davis, Matthew Wolff, Michael Wojnowicz, Derek A. Soeder, Xuan Zhao
  • Publication number: 20170213349
    Abstract: A method to segment images that contain multiple objects in a nested structure including acquiring an image; defining the multiple objects by layers, each layer corresponding to one region, where a region contains an innermost object and all the objects nested within the innermost object; stacking the layers in an order of the nested structure of the multiple objects, the stack of layers having at least a top layer and a bottom layer; extending each layer with padded nodes; connecting the top layer to a sink and the bottom layer to a source, wherein each intermediate layer between the top layer and the bottom layer are connected only to the adjacent layer by undirected links; and measuring a boundary length for each layer.
    Type: Application
    Filed: January 23, 2017
    Publication date: July 27, 2017
    Applicants: Riverside Research Institute, New York University
    Inventors: Jen-wei Kuo, Jonathan Mamou, Xuan Zhao, Jeffrey A. Ketterling, Orlando Aristizabal, Daniel H. Turnbull, Yao Wang
  • Patent number: 9705904
    Abstract: As part of an analysis of the likelihood that a given input (e.g. a file, etc.) includes malicious code, a convolutional neural network can be used to review a sequence of chunks into which an input is divided to assess how best to navigate through the input and to classify parts of the input in a most optimal manner. At least some of the sequence of chunks can be further examined using a recurrent neural network in series with the convolutional neural network to determine how to progress through the sequence of chunks. A state of the at least some of the chunks examined using the recurrent neural network summarized to form an output indicative of the likelihood that the input includes malicious code. Methods, systems, and articles of manufacture are also described.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: July 11, 2017
    Assignee: Cylance Inc.
    Inventors: Andrew Davis, Matthew Wolff, Michael Wojnowicz, Derek A. Soeder, Xuan Zhao
  • Patent number: 9700633
    Abstract: A conjugate of water soluble polymer-amino acid oligopeptide-drug of Formula (I) below and a pharmaceutical composition comprising the conjugate are provided. In the conjugate, P is a water soluble polymer; X is a linking group, wherein the linking group links P and A1; each of A1, A2 and A3 is independently same or different amino acid residue or amino acid analogue residue; each of D1 and D2 is independently same or different drug molecule residue; a is 0 or 1; b is an integer of 2-12; c is an integer of 0-7; d is 0 or 1. The conjugate could improve drug load capacity, water solubility, stability and activity of the drug.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: July 11, 2017
    Assignee: JENKEM TECHNOLOGY CO., LTD., TIANJIN BRANCH
    Inventors: Jinliang Wang, Xuan Zhao, Zhenguo Wang, Zewang Feng, Jianhuan Jia
  • Publication number: 20170119736
    Abstract: Disclosed are a compound of Formula I, having higher inhibition of protein kinase G (PKG) activity and pharmaceutically acceptable salts thereof. In Formula I, R1 and R2 are the same or different, each being independently chosen from the halogens, the C1-C6 alkoxyl group, the C1-C6 alkyl group, the C2-C6 alkenyl group, and the C2-C6 alkynyl group; R3 is chosen from H, the halogens, the substituted or unsubstituted C1-C6 alkyl group, C3-C6 cycloalkyl group, C2-C6 alkenyl group, and C2-C6 alkynyl group, aryl group, and heteroaryl group; and n is an integer between 0 and 15. Also disclosed is a pharmaceutical composition comprising said compound, the use of the compound in treating pains, in particular chronic pain, a preparation method for the compound, and a new intermediate.
    Type: Application
    Filed: January 18, 2017
    Publication date: May 4, 2017
    Inventors: Zewang Feng, Xuan Zhao, Zhenguo Wang, Yan Liu
  • Publication number: 20170095565
    Abstract: Methods of modifying the rate of systemic absorption of a drug administered to a subject by a pulmonary route, the method comprising covalently conjugating a hydrophilic polymer to a drug, wherein the drug has a half-life of elimination from the lung of less than about 180 minutes, to form a drug-polymer conjugate, wherein the drug-polymer conjugate has a net hydrophilic character and a weight average molecular weight of from about 50 to about 20,000 Daltons, and wherein the half-life of elimination from the lung of the drug-polymer conjugate is at least about 1.5-fold greater than the half-life of elimination from the lung of the drug, wherein the half-life of elimination from the lung is measured by bronchoalveolar lavage followed by assaying residual lung material.
    Type: Application
    Filed: June 9, 2016
    Publication date: April 6, 2017
    Inventors: Michael D. Bentley, Tacey X. Viegas, Richard R. Goodin, Lin Cheng, Xuan Zhao