Abstract: The present invention provides a composition of a polyethylene glycol maleimide derivative and a polymerization inhibitor. In particular, the present invention provides a composition of an 8-arm polyethylene glycol maleimide derivative and a phenolic polymerization inhibitor. The ingredient and content of the polymerization inhibitor in the composition are reasonably chosen, thereby significantly increasing stability of the polyethylene glycol maleimide derivative, effectively avoiding the undesirable effect of gel solidifying due to polymerization during storage and transportation, and extending a pot life and shelf life of a product thereof.

Abstract: An LED light with a shift switch related to the technical field of LED lights includes a diffuser, a light body, and a light head sequentially connected from top to bottom. A driving power board and an LED light source board are provided in the light body. A position hole is provided on a side wall of the light body. The driving power board is provided with the shift switch, and the shift switch is provided with a shift handle which passes through the position hole. According to the present application, the effects of reducing the difficulty of modification and replacement and improving the convenience of using the LED light are achieved by controlling the color temperature, the timing or the light intensity of the LED light by multiple positions of the shift switch.

Abstract: An LED tube light with a color adjustment switch related to the technical field of home appliances includes an LED tube light body. The LED tube light body is provided with a tube light body and terminals located at two ends of the tube light body and used for connecting with a mounting seat. The tube light body includes a light tube, an LED light strip with at least two different color temperatures, and a driving power source electrically connected with the LED light strip. The LED tube light body further includes at least one color adjustment switch fixed on the respective terminal. The color adjustment switch is configured to control the on and off of different color temperatures of the LED light strip.

Abstract: A cross reality system enables any of multiple types of devices to efficiently and accurately access previously stored maps and render virtual content specified in relation to those maps. The cross reality system may include a cloud-based localization service that responds to requests from devices to localize with respect to a stored map. Devices of any type, with native hardware and software configured for augmented reality operations may be configured to work with the cross reality system by incorporating components that interface between the native AR framework of the device and the cloud-based localization service. These components may present position information about the device in a format recognized by the localization service. Additionally, these components may filter or otherwise process perception data provided by the native AR framework to increase the accuracy of localization.

Abstract: The present invention discloses a method of preparing PEGylated biomolecules having controllable binding sites, including the following steps: (1) binding a blocker to a biomolecule; (2) PEGylating the biomolecule; and (3) separating the blocker from the biomolecule. In another aspect, the present invention discloses a method for preparing PEGylated IL-2 having controllable binding sites, including the following steps: (1) binding IL-2 to an IL-2? receptor, closing the a binding site of the IL-2; (2) PEGylating, coupling PEG with the IL-2; and (3) separating the IL-2 from the IL-2? receptor. By regulating IL-2 binding sites and a PEGylation process only adding one or two polyethylene glycols, the IL-2 is caused to selectively bind to an IL-2R ??-type receptor.

Abstract: A cross reality system that provides an immersive user experience by storing persistent spatial information about the physical world that one or multiple user devices can access to determine position within the physical world and that applications can access to specify the position of virtual objects within the physical world. Persistent spatial information enables users to have a shared virtual, as well as physical, experience when interacting with the cross reality system. Further, persistent spatial information may be used in maps of the physical world, enabling one or multiple devices to access and localize into previously stored maps, reducing the need to map a physical space before using the cross reality system in it. Persistent spatial information may be stored as persistent coordinate frames, which may include a transformation relative to a reference orientation and information derived from images in a location corresponding to the persistent coordinate frame.

Abstract: A system is provided for training a machine learning model to detect malicious container files. The system may include at least one processor and at least one memory. The memory may include program code which when executed by the at least one processor provides operations including: processing a container file with a trained machine learning model, wherein the trained machine learning is trained to determine a classification for the container file indicative of whether the container file includes at least one file rendering the container file malicious; and providing, as an output by the trained machine learning model, an indication of whether the container file includes the at least one file rendering the container file malicious. Related methods and articles of manufacture, including computer program products, are also disclosed.

Abstract: A model simplification method is provided. The model simplification method includes: constructing a surrounding body to surround a model, wherein the model includes at least one primitive and a plurality of vertexes; drawing the model and the surrounding body to at least one rendering surface by respectively taking each of the plurality of vertexes as an eye-position; determining whether the surrounding body drawn on the rendering surface by taking a current vertex of the plurality of vertexes as the eye-position is occluded to decide whether to mark the current vertex as an invisible vertex; and eliminating a current primitive from the model when all vertexes of the current primitive of the at least one primitive are marked as the invisible vertex.

Abstract: Provided herein are water-soluble prodrugs, compositions comprising such prodrugs, and related methods of making and administering the same. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are typically covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water-soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.

Abstract: An electronic apparatus and a method for reducing the number of commands are provided. The electronic apparatus includes a central processor and a co-processor. The central processor generates a plurality of original register setting commands to set at least one bit of at least one register of the co-processor. The original register setting commands include a plurality of first original register setting commands, and a plurality of setting targets of the first original register setting commands have address continuity. The central processor merges the first original register setting commands to generate at least one merged register setting command. The central processor transmits the at least one merged register setting command to the co-processor.

Abstract: The invention discloses a fulvic acid sterilization deodorant as well as a preparation method and application thereof, and belongs to the technical field of deodorants. Natural polymer compound fulvic acid is modified to prepare a fulvic acid surfactant which is compounded with plant extract to prepare the deodorant with good sterilization and deodorization effects. The fulvic acid with strong hydrophilicity is enhanced in surface activity by introducing a lipophilic end through reaction with a cationic surfactant; an emulsifier is introduced to the fulvic acid solution and the plant extract with strong volatility to prolong interaction between deodorant and odor molecules, achieving an efficient removal purpose. The preparation method is simple in process and low in cost, adopts easily-available raw materials, and can achieve large-scale production.

Abstract: A model simplification method is provided. The model simplification method includes: constructing a surrounding body to surround a model, wherein the model includes at least one primitive and a plurality of vertexes; drawing the model and the surrounding body to at least one rendering surface by respectively taking each of the plurality of vertexes as an eye-position; determining whether the surrounding body drawn on the rendering surface by taking a current vertex of the plurality of vertexes as the eye-position is occluded to decide whether to mark the current vertex as an invisible vertex; and eliminating a current primitive from the model when all vertexes of the current primitive of the at least one primitive are marked as the invisible vertex.

Abstract: A cross reality system enables any of multiple types of devices to efficiently and accurately access previously stored maps and render virtual content specified in relation to those maps. The cross reality system may include a cloud-based localization service that responds to requests from devices to localize with respect to a stored map. Devices of any type, with native hardware and software configured for augmented reality operations may be configured to work with the cross reality system by incorporating components that interface between the native AR framework of the device and the cloud-based localization service. These components may present position information about the device in a format recognized by the localization service. Additionally, these components may filter or otherwise process perception data provided by the native AR framework to increase the accuracy of localization.

Abstract: The present invention provides a cell-penetrating-peptide multi-arm-PEG medicine conjugate having a general formula I, II, III, IV or V. As compared with linear-chain-type PEG-cell-penetrating-peptide conjugates, the multi-arm PEG has multiple end groups, and has introduction sites for multiple functional groups, which can connect to multiple different active groups. In addition, the cell-penetrating-peptide multi-arm-PEG medicine conjugate to enable the medicine to enter the pathogenetic cells in a targeting manner, to achieve precise treatment. The present invention further provides use of a cell-penetrating-peptide multi-arm-PEG medicine conjugate having targeting ability in preparation of a targeting medicine, especially use of a cell-penetrating-peptide multi-arm-PEG medicine conjugate having targeting ability in the treatment of eye age-related macular degeneration, asthma and pulmonary fibrosis.

Abstract: The present disclosure provides binding agents, such as antibodies, that specifically bind LAIR-1, including human LAIR-1, as well as compositions comprising the binding agents, and methods of their use. The disclosure also provides related polynucleotides and vectors encoding the binding agents and cells comprising the binding agents.

Abstract: The invention discloses a humic acid type adsorption material as well as a preparation method and application thereof. The humic acid type adsorption material is prepared by taking carboxymethyl cellulose or salts thereof, humate and montmorillonite as raw materials and adding a monomer, a cross-linking agent and an initiator through aqueous solution polymerization. The synthesized porous material is great in specific surface area, can quickly get close to water molecules in water to form hydrogen bonds, and finally achieves the purpose of removing organic dye pollutants through electrostatic attraction effect with dye molecules. The humic acid type adsorption material is low in raw material price, is simple in synthesis process, and is green and environmentally friendly.

Abstract: An apparatus configured to be worn on a head of a user, includes: a screen configured to present graphics to the user; a camera system configured to view an environment in which the user is located; and a processing unit configured to determine a map based at least in part on output(s) from the camera system, wherein the map is configured for use by the processing unit to localize the user with respect to the environment; wherein the processing unit of the apparatus is also configured to obtain a metric indicating a likelihood of success to localize the user using the map, and wherein the processing unit is configured to obtain the metric by computing the metric or by receiving the metric.

Abstract: A cross reality system that provides an immersive user experience by storing persistent spatial information about the physical world that one or multiple user devices can access to determine position within the physical world and that applications can access to specify the position of virtual objects within the physical world. Persistent spatial information enables users to have a shared virtual, as well as physical, experience when interacting with the cross reality system. Further, persistent spatial information may be used in maps of the physical world, enabling one or multiple devices to access and localize into previously stored maps, reducing the need to map a physical space before using the cross reality system in it. Persistent spatial information may be stored as persistent coordinate frames, which may include a transformation relative to a reference orientation and information derived from images in a location corresponding to the persistent coordinate frame.

Abstract: The present invention provides a composition of a polyethylene glycol maleimide derivative and a polymerization inhibitor. In particular, the present invention provides a composition of an 8-arm polyethylene glycol maleimide derivative and a phenolic polymerization inhibitor. The ingredient and content of the polymerization inhibitor in the composition are reasonably chosen, thereby significantly increasing stability of the polyethylene glycol maleimide derivative, effectively avoiding the undesirable effect of gel solidifying due to polymerization during storage and transportation, and extending a pot life and shelf life of a product thereof.

Abstract: An LED bulb includes an LED photoelectric module having at least two branches of LED beads with different color temperatures connected in parallel, a control switch connected with one of the branches of LED beads, and an adjustment ring. A total voltage of one branch of LED beads is less than that of each of the other branches of LED beads. The control switch has a ball, the adjustment ring has a magnet, and when the adjustment ring rotates, the magnet draws the ball to roll to switch on or off the control switch. When the control switch is on, the branch of LED beads connected with the control switch is lighted up, and when the control switch is off, the branch of LED beads connected with the control switch is not lighted up.