Patents by Inventor Xuan Zhao

Xuan Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10046987
    Abstract: A method of treatment of radioactive wastewater. The method includes: allowing radioactive wastewater to undergo reverse osmosis treatment and continuous electrodeionization treatment in sequence. The continuous electrodeionization treatment is carried out in a continuous electrodeionization unit including a continuous electrodeionization membrane stack including a dilute chamber and a concentrate chamber. The dilute chamber is filled with between 30 and 60 vol. % of a first strong-acid cation exchange resin, between 40 and 60 vol. % of a first strong-base anion exchange resin, and between 0 and 30 vol. % of a weak-base anion exchange resin. The concentrate chamber is filled with between 20 and 50 vol. % of a second strong-acid cation exchange resin, and the rest is a second strong-base anion exchange resin.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: August 14, 2018
    Assignee: TSINGHUA UNIVERSITY
    Inventors: Xuan Zhao, Fuzhi Li, Meng Zhang
  • Patent number: 10039837
    Abstract: Provided is a multi-arm polyethylene glycol-azido derivative of general formula I, wherein R is a central molecule, which is selected from a polyhydroxy structure, a polyamino structure or a polycarboxyl structure; n is the number of branches or arms, n?3; PEG is the same or different —(CH2CH2O)m—, the average value of m being an integer from 3 to 250; X is a linking group of a azido end group; k is the number of the branches having the azido end group; F is selected from the group consisting of amino, carboxyl, sulfhydryl, ester group, maleic imide group and acrylic group; and Y is a linking group of an end group F.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: August 7, 2018
    Assignee: JENKEM TECHNOLOGY CO., LTD. (TIANJIN)
    Inventors: Xiaomeng Chen, Meina Lin, Xuan Zhao
  • Patent number: 10034948
    Abstract: Provided are polyethylene glycol drug conjugates of general formula (I), (II) or (III) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules. The conjugates can interact with receptor dimers or polymers, thereby improving the in vivo distribution of the drug, changing the oil and water distribution coefficient, enhancing the pharmacological activity, reducing the blood-brain barrier permeability of the drug, and improving the bioavailability of the drug.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: July 31, 2018
    Assignee: JENKEM TECHNOLOGY CO., LTD.
    Inventors: Lihua Xu, Xuan Zhao, Zewang Feng, Jinliang Wang, Zhen'guo Wang
  • Publication number: 20180177884
    Abstract: Provided are polyethylene glycol drug conjugates of general formula (I), (II) or (III) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules. The conjugates can interact with receptor dimers or polymers, thereby improving the in vivo distribution of the drug, changing the oil and water distribution coefficient, enhancing the pharmacological activity, reducing the blood-brain barrier permeability of the drug, and improving the bioavailability of the drug.
    Type: Application
    Filed: September 8, 2017
    Publication date: June 28, 2018
    Inventors: Lihua XU, Xuan ZHAO, Zewang FENG, Jinliang WANG, Zhen'guo WANG
  • Publication number: 20180157826
    Abstract: Determining, by a machine learning model in an isolated operating environment, whether a file is safe for processing by a primary operating environment. The file is provided, when the determining indicates the file is safe for processing, to the primary operating environment for processing by the primary operating environment. When the determining indicates the file is unsafe for processing, the file is prevented from being processed by the primary operating environment. The isolated operating environment can be maintained on an isolated computing system remote from a primary computing system maintaining the primary operating system. The isolating computing system and the primary operating system can communicate over a cloud network.
    Type: Application
    Filed: February 1, 2018
    Publication date: June 7, 2018
    Inventors: Ryan Permeh, Derek A. Soeder, Matthew Wolff, Ming Jin, Xuan Zhao
  • Publication number: 20180144130
    Abstract: In one respect, there is provided a system for training a neural network adapted for classifying one or more scripts. The system may include at least one processor and at least one memory. The memory may include program code that provides operations when executed by the at least one memory. The operations may include: extracting, from an icon associated with a file, one or more features; assigning, based at least on the one or more features, the icon to one of a plurality of clusters; and generating, based at least on the cluster to which the icon is assigned, a classification for the file associated with the icon. Related methods and articles of manufacture, including computer program products, are also provided.
    Type: Application
    Filed: November 21, 2016
    Publication date: May 24, 2018
    Inventors: Matthew Wolff, Pedro Silva do Nascimento Neto, Xuan Zhao, John Brock, Jian Luan
  • Publication number: 20180117043
    Abstract: The present invention provides use of a Src protein inhibitor N-(2-chloro-6-methylphenyl)-2-{6-[4-(3-hydroxyethyl)-1-piperazinyl]-2 -methyl-4-pyrimidinylamino}-5-thiazolecarboxamide (formula I) in the manufacture of a medicament for the prophylaxis and/or treatment of Alzheimer's disease. An A?42 oligomer and a tested drug were applied to primary isolated fetal mouse cerebral cortical neuron for 24 h to test the efficacy of the compound of formula I at different concentrations against A?42 oligomer toxicity in vitro, and the results show that the compound of formula I has a wide range of effective concentration and high cell viability at effective concentration.
    Type: Application
    Filed: December 20, 2017
    Publication date: May 3, 2018
    Inventors: Zewang FENG, Jinliang WANG, Yan LIU, Xuan ZHAO
  • Publication number: 20180110867
    Abstract: A conjugate represented by general formula (I), wherein R0 is a C1-6 alkyl, B is an anesthetic, and A is a linking group, and a quaternary ammonium salt is formed at the linking position between B and R0. The conjugate has a prolonged analgesic effect, and can be used in postoperative analgesia or treatment for chronic pain.
    Type: Application
    Filed: December 20, 2017
    Publication date: April 26, 2018
    Inventors: Jinliang Wang, Zewang Feng, Hui Zhu, Meina Lin, Yan Liu, Xuan Zhao
  • Patent number: 9946876
    Abstract: A plurality of data files is received. Thereafter, each file is represented as an entropy time series that reflects an amount of entropy across locations in code for such file. A wavelet transform is applied, for each file, to the corresponding entropy time series to generate an energy spectrum characterizing, for the file, an amount of entropic energy at multiple scales of code resolution. It can then be determined, for each file, whether or not the file is likely to be malicious based on the energy spectrum. Related apparatus, systems, techniques and articles are also described.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: April 17, 2018
    Assignee: Cylance Inc.
    Inventors: Michael Wojnowicz, Glenn Chisholm, Matthew Wolff, Derek A. Soeder, Xuan Zhao
  • Patent number: 9928363
    Abstract: Determining, by a machine learning model in an isolated operating environment, whether a file is safe for processing by a primary operating environment. The file is provided, when the determining indicates the file is safe for processing, to the primary operating environment for processing by the primary operating environment. When the determining indicates the file is unsafe for processing, the file is prevented from being processed by the primary operating environment. The isolated operating environment can be maintained on an isolated computing system remote from a primary computing system maintaining the primary operating system. The isolating computing system and the primary operating system can communicate over a cloud network.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: March 27, 2018
    Assignee: Cylance Inc.
    Inventors: Ryan Permeh, Derek A. Soeder, Matthew Wolff, Ming Jin, Xuan Zhao
  • Patent number: 9925171
    Abstract: Disclosed are a compound of Formula I, having higher inhibition of protein kinase G (PKG) activity and pharmaceutically acceptable salts thereof. In Formula I, R1 and R2 are the same or different, each being independently chosen from the halogens, the C1-C6 alkoxyl group, the C1-C6 alkyl group, the C2-C6 alkenyl group, and the C2-C6 alkynyl group; R3 is chosen from H, the halogens, the substituted or unsubstituted C1-C6 alkyl group, C3-C6 cycloalkyl group, C2-C6 alkenyl group, and C2-C6 alkynyl group, aryl group, and heteroaryl group; and n is an integer between 0 and 15. Also disclosed is a pharmaceutical composition comprising said compound, the use of the compound in treating pains, in particular chronic pain, a preparation method for the compound, and a new intermediate.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: March 27, 2018
    Assignee: JENKEM TECHNOLOGY CO., LTD., (TIANJIN)
    Inventors: Zewang Feng, Xuan Zhao, Zhenguo Wang, Yan Liu
  • Publication number: 20180075348
    Abstract: In one respect, there is provided a system for classifying an instruction sequence with a machine learning model. The system may include at least one processor and at least one memory. The memory may include program code that provides operations when executed by the at least one processor. The operations may include: processing an instruction sequence with a trained machine learning model configured to detect one or more interdependencies amongst a plurality of tokens in the instruction sequence and determine a classification for the instruction sequence based on the one or more interdependencies amongst the plurality of tokens; and providing, as an output, the classification of the instruction sequence. Related methods and articles of manufacture, including computer program products, are also provided.
    Type: Application
    Filed: November 7, 2016
    Publication date: March 15, 2018
    Inventors: Xuan Zhao, Matthew Wolff, John Brock, Brian Wallace, Andrew Wortman, Jian Luan, Mahdi Azarafrooz, Andrew Davis, Michael Wojnowicz, Derek Soeder, David Beveridge, Eric Petersen, Ming Jin, Ryan Permeh
  • Publication number: 20180075349
    Abstract: In one respect, there is provided a system for training a neural network adapted for classifying one or more instruction sequences. The system may include at least one processor and at least one memory. The memory may include program code which when executed by the at least one processor provides operations including: training, based at least on training data, a machine learning model to detect one or more predetermined interdependencies amongst a plurality of tokens in the training data; and providing the trained machine learning model to enable classification of one or more instruction sequences. Related methods and articles of manufacture, including computer program products, are also provided.
    Type: Application
    Filed: November 7, 2016
    Publication date: March 15, 2018
    Inventors: Xuan Zhao, Matthew Wolff, John Brock, Brian Wallace, Andrew Wortman, Jian Luan, Mahdi Azarafrooz, Andrew Davis, Michael Wojnowicz, Derek Soeder, David Beveridge, Eric Petersen, Ming Jin, Ryan Permeh
  • Publication number: 20180063169
    Abstract: In one respect, there is provided a system for training a machine learning model to detect malicious container files. The system may include at least one processor and at least one memory. The memory may include program code which when executed by the at least one processor provides operations including: processing a container file with a trained machine learning model, wherein the trained machine learning is trained to determine a classification for the container file indicative of whether the container file includes at least one file rendering the container file malicious; and providing, as an output by the trained machine learning model, an indication of whether the container file includes the at least one file rendering the container file malicious. Related methods and articles of manufacture, including computer program products, are also disclosed.
    Type: Application
    Filed: November 7, 2016
    Publication date: March 1, 2018
    Inventors: Xuan Zhao, Matthew Wolff, John Brock, Brian Wallace, Andrew Wortman, Jian Luan, Mahdi Azarafrooz, Andrew Davis, Michael Wojnowicz, Derek Soeder, David Beveridge, Yaroslav Oliinyk, Ryan Permeh
  • Publication number: 20180060580
    Abstract: In one respect, there is provided a system for training a machine learning model to detect malicious container files. The system may include at least one processor and at least one memory. The at least one memory may include program code that provides operations when executed by the at least one processor. The operations may include: training, based on a training data, a machine learning model to enable the machine learning model to determine whether at least one container file includes at least one file rendering the at least one container file malicious; and providing the trained machine learning model to enable the determination of whether the at least one container file includes at least one file rendering the at least one container file malicious. Related methods and articles of manufacture, including computer program products, are also disclosed.
    Type: Application
    Filed: November 7, 2016
    Publication date: March 1, 2018
    Inventors: Xuan Zhao, Matthew Wolff, John Brock, Brian Wallace, Andrew Wortman, Jian Luan, Mahdi Azarafrooz, Andrew Davis, Michael Wojnowicz, Derek Soeder, David Beveridge, Yaroslav Oliinyk, Ryan Permeh
  • Patent number: 9897433
    Abstract: A wafer metrology system includes an interferometer sub-system and a controller. The interferometer sub-system is configured to generate an interferogram with an intensity map that corresponds to a modulated representation of a wafer surface. Further, the interferometer sub-system includes a detector configured to capture the interferogram. The controller includes one or more processors configured to generate a wrapped phase map of the interferogram, define patterns associated with features on the wafer, and correct phase discontinuities by applying a phase unwrapping procedure to the wrapped phase map to generate an unwrapped phase map and correcting phase discontinuities in the unwrapped phase map based on the patterns, or by combining phase unwrapping and correction in a unified step. Further, the patterns comprise two or more structures such that a portion of the unwrapped phase map associated with structures of the same type is continuous across borders separating structures of the same type.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: February 20, 2018
    Assignee: KLA—Tencor Corporation
    Inventors: Helen Liu, Xuan Zhao, Xiaowei Li
  • Publication number: 20180044280
    Abstract: The present invention discloses a Y-type discrete polyethylene glycol derivative and a preparation method thereof, which has the advantages of determined molecular weights and the number of chain segments, and can avoid the defect of heterogeneity of a PEG derivative, meanwhile the preparation method has simple steps, mild conditions, without need for strictly anhydrous environment or performing protection and deprotection steps. In addition, the Y-type discrete polyethylene glycol derivative of the present invention may increase the water solubility of the discrete polyethylene glycol, and solve the problem of insufficient water solubility of the discrete polyethylene glycol-modified insoluble drug caused by an increase of the loading capacity.
    Type: Application
    Filed: October 23, 2017
    Publication date: February 15, 2018
    Inventors: Hui ZHU, Meina LIN, Xiaomeng CHEN, Zhen'gang ZHU, Xuan ZHAO
  • Publication number: 20180021443
    Abstract: Provided are polyethylene glycol drug conjugates of general formula (I), (II) or (III) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules. The conjugates can interact with receptor dimers or polymers, thereby improving the in vivo distribution of the drug, changing the oil and water distribution coefficient, enhancing the pharmacological activity, reducing the blood-brain barrier permeability of the drug, and improving the bioavailability of the drug.
    Type: Application
    Filed: September 8, 2017
    Publication date: January 25, 2018
    Inventors: Lihua XU, Xuan ZHAO, Zewang FENG, Jinliang WANG, Zhen'guo WANG
  • Publication number: 20180021444
    Abstract: Provided herein are water-soluble prodrugs, compositions comprising such prodrugs, and related methods of making and administering the same. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are typically covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water-soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.
    Type: Application
    Filed: October 3, 2017
    Publication date: January 25, 2018
    Inventors: Xuan Zhao, Michael D. Bentley, Zhongxu Ren, Tacey X. Viegas
  • Publication number: 20180021442
    Abstract: Provided are polyethylene glycol drug conjugates of general formula (I), (II) or (III) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules. The conjugates can interact with receptor dimers or polymers, thereby improving the in vivo distribution of the drug, changing the oil and water distribution coefficient, enhancing the pharmacological activity, reducing the blood-brain barrier permeability of the drug, and improving the bioavailability of the drug.
    Type: Application
    Filed: September 8, 2017
    Publication date: January 25, 2018
    Inventors: Lihua XU, Xuan ZHAO, Zewang FENG, Jinliang WANG, Zhen'guo WANG