Abstract: A method for predicting a chemical reaction using projection of an orbital coefficient vector is provided. The method includes calculating coefficient vector projections along multiple possible valence orbital overlap directions in a molecule by means of a developed valence orbital coefficient vector projection method, thereby obtaining reaction indices such as atomic vectorial reaction indices for different sites and directions. Through comparison of the atomic vectorial reaction indices for different sites, reactivity of a site can be predicted, that is, likelihood of an atom participating in a chemical reaction at that site. By calculating the atomic vectorial reaction indices, directional charge densities, and corresponding reaction energy barriers for different sites, likelihood of chemical reactions occurring at multiple potential reactive sites in the molecule can be quantitatively and directionally predicted.

Abstract: Methods and systems for determining when to trigger an abort process during semiconductor manufacturing processing are disclosed. An exemplary method includes measuring a plurality of resistances of the heat lamp during a time period, performing N consecutive comparisons of a prior resistance of the measured plurality of resistances to a current resistance of the measured plurality of resistances, to determine whether a difference between each comparison of the prior resistance and the current resistance exceeds a threshold, triggering the abort process based on the difference between each of the N consecutive comparisons of the prior resistance and the current resistance exceeding the threshold, and generating one or more instructions to suspend the semiconductor fabrication process based on triggering the abort process. An exemplary system can perform the method of determining when to trigger an abort process.

Abstract: The present disclosure discloses anti-BCL6 nanobody, fusion protein comprising the same and use thereof, which belong to the field of biotechnology. In the present disclosure, artificial intelligence technology is employed to design nanobodies specifically targeting BCL6. The nanobodies exhibit favorable specificity and high affinity, and can efficiently bind to BCL6 antigen. Furthermore, rational design of the nanobodies is performed via artificial intelligence to obtain nanobody mutants with higher affinity. Furthermore, fusion proteins are obtained by fusing the nanobodies or nanobody mutants with high affinity and favorable specificity with an RBCC domain or a mutant thereof. The fusion proteins can specifically bind to the target protein via their nanobody domains, activate the protein degradation pathway, and achieve targeted degradation of BCL6 protein, thereby upregulating the intracellular expression of the tumor suppressor gene p53 and cyclin p21, which has great clinical application value.

Abstract: The present disclosure provides a binder that specifically targets the PCNA protein, a fusion protein comprising the same, and uses thereof, which belong to the field of biotechnology. In the present disclosure, artificial intelligence technology is employed to design binders that specifically target PCNA. The resulting binders exhibit good specificity and high affinity, and are capable of efficiently binding to the PCNA antigen. Further, fusion proteins are prepared by fusing the aforementioned binders to an RBCC domain or a mutant thereof, or by directly fusing the aforementioned binders to an Fc fragment.

Abstract: The present disclosure provides anti-PCNA nanobodies, fusion proteins comprising the same, and uses thereof, which belong to the field of biotechnology. In the present disclosure, artificial intelligence technology is employed to design nanobodies that specifically target PCNA. The nanobodies exhibit favorable specificity and high affinity, and are capable of efficiently binding to the PCNA antigen. Further, rational design of the nanobodies via artificial intelligence technology yields nanobody mutants with higher affinity. Moreover, fusion proteins are prepared by fusing the aforementioned nanobodies or nanobody mutants with an RBCC domain or its mutant.

Abstract: Methods, apparatus and systems for processing video are described. One example method includes performing a conversion between a video comprising a video unit and a bitstream of the video, wherein the bitstream conforms to a format rule, and wherein the format rule specifies that a first syntax element indicating whether an in-loop filtering operation is performed across slice boundaries is conditionally included in the bitstream responsive to whether or how the video unit is partitioned into slices.

Abstract: A method of processing video data includes selecting a first dependent quantization (DQ) parameter to be applied to a first video unit within a sequence; selecting a second DQ parameter to be applied to a second video unit within the sequence, wherein the second DQ parameter is different from the first DQ parameter; and converting between a video media file and a bitstream based on the first DQ parameter and the second DQ parameter that were selected. A corresponding video coding apparatus and non-transitory computer readable medium are also disclosed.

Abstract: The present invention relates to an antibody specifically targeting B7-H4, and a preparation method therefor and the use thereof. In the present invention, the method comprises screening, on the basis of a phage display technique, an antibody variable region targeting B7-H4, then transforming same into a full-length antibody, constructing an expression vector, performing eukaryotic expression and purification so as to obtain the antibody specifically targeting B7-H4.

Abstract: A mechanism for processing video data is disclosed. A value of an extended dependent random-access point (EDRAP) leading pictures decodable flag (edrap_leading_pictures_decodable_flag) syntax element is determined. A conversion can then be performed between a visual media data and a bitstream based on the edrap_leading_pictures_decodable_flag syntax element. The value of the edrap_leading_pictures_decodable_flag indicates whether ordering constraints are imposed on the EDRAP picture.

Abstract: Embodiments of the present disclosure provide a solution for video processing. A method for video processing is proposed. The method comprises: constructing a list of merge candidates for a target block of a video in a coding mode based on motion vector difference (MVD); reordering the list of merge candidates for the target block; and performing a conversion between the target block and a bitstream of the video based on the reordered list of merge candidates. Compared with the conventional solution, the proposed method can advantageously improve the coding efficiency.

Abstract: A display substrate and a manufacturing method thereof, and a display device relate to the technical field of displaying. The display substrate includes a base substrate; a pixel defining layer; and a common transport layer arranged at one side of the pixel defining layer away from the base substrate, including a first blocking pattern and first transport patterns surrounding the first blocking pattern. An orthographic projection of the first blocking pattern on the base substrate does not overlap with an orthographic projection of the plurality of opening areas on the base substrate. An area of the orthographic projection of the first transport pattern on the base substrate is larger than an area of the orthographic projection of the first blocking pattern on the base substrate.

Abstract: Embodiments of the present disclosure provide a solution for video processing. A method for video processing is proposed. The method comprises: determining, during a conversion between a target block of a video and a bitstream of the target block, whether to apply a sample-based optical flow coding method based on a condition associated with the target block; and performing the conversion based on the determining.

Abstract: Embodiments of the disclosure provide a solution for video processing. A method for video processing is proposed. The method includes: refining, for a conversion between a video unit of a video and a bitstream of the video, a sample of the video unit by applying a local illumination compensation (LIC), where the video unit is coded with a geometric partitioning mode (GPM); and performing the conversion based on the refined sample.

Abstract: The invention provides anti-ETEC adhesin protein antibodies and methods of using the same.

Abstract: Embodiments of the present disclosure disclose a model management apparatus, method and system, where the apparatus includes a model storage module and a model update module; the model storage module is configured to store at least one functional model; the model update module is connected to the model storage module, and is configured to obtain a target functional model to be updated from the model storage module according to a received update instruction, perform functional update on the target functional model to be updated based on a target model data set, and transmit an updated target functional model to the model storage module for storage; where the target functional model is called by a model application apparatus to cause the model application apparatus to implement a set function, and the model application apparatus and the model management apparatus are set up independently of each other.

Abstract: Embodiments of the present disclosure provide a solution for video processing. A method for video processing is proposed. The method comprises: determining, during a conversion between a target video block of a video and a bitstream of the video, a first motion vector candidate from a first direction of the target video block based on a motion vector refinement, the target video block being in a bi-prediction mode; and performing the conversion based at least in part on the first motion vector candidate.

Abstract: Embodiments of the present disclosure provide a solution for video processing. A method for video processing is proposed. The method comprises: determining, during a conversion between a target block in a target picture of a video and a bitstream of the video, first motion information of the target block based on a regular merge mode, the first motion information comprising a regular merge list of regular merge candidates for the target block; determining second motion information from the first motion information based on a geometric partitioning-based merge mode and a redundancy check, the second motion information comprising a geometric partitioning-based merge list of geometric partitioning-based merge candidates for the target block; and performing the conversion based on the first motion information and the second motion information. Compared with the conventional solution, the proposed method can advantageously improve the coding efficiency and compression ratios.

Abstract: An extended anti-pinch leg mechanism includes a leg connecting rod I. The leg connecting rods I to IV are pivotally connected in sequence, the leg connecting rods III and IV are pivotally connected to a large footrest mounting member, and the large footrest mounting member, the footrest connecting rod I, a small footrest mounting member and the footrest connecting rod II are pivotally connected in sequence to form a quadrilateral structure. A baffle is provided at the front end of the large footrest mounting member, a protrusion is provided at the rear end of the footrest connecting rod I, the protrusion is pivotally connected to the footrest connecting rod III through the shaft I, the rear end of the footrest connecting rod III is pivotally connected to the leg connecting rod IV through the shaft II, and a bushing is sleeved outside the shaft II.