Abstract: There is provided a cell quality evaluation apparatus that performs a process including estimation processing of estimating a quality of cells in the entirety of a cell-culture container by determining feature quantities from a plurality of images and calculating an average value of the feature quantities; derivation processing of deriving an estimation error of the quality estimated in the estimation processing, based on a variation of the feature quantities in the plurality of images and imaging information related to an area of a plurality of imaging regions; and imaging control processing of causing a imaging apparatus to perform re-imaging on at least one re-imaging region different from the plurality of imaging regions in a case where the estimation error is out of an allowable range.

Abstract: An observation apparatus includes an acquisition unit that acquires positional information indicating a position of a bottom surface of a support for supporting an observation target, an imaging optical system that forms an optical image showing the observation target supported by the support on an image plane, a focus adjustment unit that adjusts a focal position of the imaging optical system based on the positional information acquired by the acquisition unit, and a control unit that performs control for matching an inclination of the image plane on which the optical image is formed to an inclination of an imaging surface of an imaging element based on the positional information acquired by the acquisition unit.

Abstract: An information processing apparatus for predicting a success or failure of differentiation of cells on the basis of a captured image obtained by imaging a cell population cultured in a cell-culture container includes at least one processor. The at least one processor extracts a feature quantity based on an appearance of the cells by performing image processing on the captured image, and predicts the success or failure of differentiation of the cells on the basis of the extracted feature quantity.

Abstract: The keyboard instrument includes mounting members (a first member and a second member) and a key base member 300 in which the mounting members are mounted on side surfaces. On the lower side of the side surfaces, there are lower groove portions that cannot be visually recognized from the outside when the mounting members are attached.

Abstract: A keyboard instrument includes a key which includes a weight, and a key base including a top plate and at least one rib configured to fix the weight by holding the weight from below in such a state that the weight is kept in abutment with a lower surface of the top plate.

Abstract: A keyboard instrument includes a key base member, a first member which is disposed on either of a left and a right of the key base member, and a second member which is disposed on the other side of disposing the first member, and a length hb in an up-down direction of a portion of the first member which corresponds to a nearer side of a key differs from a length ha in the up-down direction of a portion of the second member which corresponds to the nearer side of the key.

Abstract: An object of the present invention is to provide a method of producing a pluripotent stem cell capable of differentiating into a specific cell. According to the present invention, there is provided a method for producing a pluripotent stem cell capable of differentiating into a specific cell, the method including (i) a step of measuring, in a pluripotent stem cell as a sample, a phenotype associated with induction of epithelial-mesenchymal transition before differentiation induction; and (ii) a step of acquiring a pluripotent stem cell capable of differentiating into a specific cell using the measured phenotype as an indicator. According to the present invention, there are further provided a method of selecting a pluripotent stem cell capable of differentiating into a specific cell; a pluripotent stem cell capable of differentiating into a specific cell; a production method of a differentiated cell; a differentiated cell; and a method for quality evaluation of a pluripotent stem cell.

Abstract: The observation device includes an imaging optical system that includes an imaging lens forming an image of an observation target in a cultivation container, an operating section that performs at least one of a first operation of changing a focal length of the imaging optical system, a second operation of moving the imaging lens in an optical axis direction, or a fourth operation of moving the container in the optical axis direction, a detection section that detects a vertical position of the cultivation container, and an operation controller that controls the operating section based on the vertical position of the cultivation container.

Abstract: Before an observation region of the imaging optical system reaches an observation position in a culture container, a vertical position of the culture container at the observation position is precedently detected by an auto-focus displacement sensor. In a case where an auto-focus control is performed on the basis of the position, an error between the precedently detected vertical position of the container at the observation position and a vertical position of the container at a time point when an observation region of the imaging optical system is scanned up to the observation position is acquired, and an objective lens is moved in an optical axis direction on the basis of the error.

Abstract: An information processing apparatus includes an acquisition unit that acquires an output image output from a trained model as a result of causing the trained model to perform semantic segmentation in which discrimination of a class which is a type of an object appearing in an input image is performed on a pixel-by-pixel basis, an evaluation unit that evaluates validity of the semantic segmentation based on the output image, and a display controller that performs control such that an evaluation result indicating that the semantic segmentation does not have validity is displayed in a case where the evaluation unit evaluates that the semantic segmentation does not have validity.

Abstract: An observation apparatus includes an acquisition unit that acquires positional information indicating a position of a bottom surface of a support for supporting an observation target, an imaging optical system that forms an optical image showing the observation target supported by the support on an image plane, a focus adjustment unit that adjusts a focal position of the imaging optical system based on the positional information acquired by the acquisition unit, and a control unit that performs control for matching an inclination of the image plane on which the optical image is formed to an inclination of an imaging surface of an imaging element based on the positional information acquired by the acquisition unit.

Abstract: Before an observation region of an imaging optical system (14) reaches an observation position in the cultivation container (50), a vertical position of the cultivation container (50) at the observation position is precedently detected by an auto-focus displacement sensor. In a case where an objective lens is moved in an optical axis direction on the basis of the position, an error between the precedently detected vertical position of the stage (51) at the observation position and a vertical position of the stage (51) at a time point when the observation region of the imaging optical system (14) is scanned up to the observation position is acquired, and the objective lens is moved in the optical axis direction on the basis of the error.

Abstract: A detection section detects a position of a container in a vertical direction, and an imaging optical system controller acquires an adjustment value of an imaging position of an imaging optical system according to the detected position. A correction section corrects the adjustment value according to a change in a refractive index of the container according to a temperature of the container. The imaging optical system controller adjusts an imaging position of an observation target on the basis of the corrected adjustment value.

Abstract: A phase contrast microscope includes: an illumination light emission unit that emits illumination light for phase difference measurement to a container in which a liquid and an observation target are contained; an imaging unit that images the observation target irradiated with the illumination light; an adjustment optical system that adjusts refraction of the illumination light due to a liquid surface shape of the liquid in the container; a liquid surface shape estimation unit that estimates the liquid surface shape of the liquid in the container based on a brightness distribution of a phase difference image of the observation target captured by the imaging unit; and an adjustment information acquisition unit that acquires adjustment information for adjusting optical characteristics of the adjustment optical system based on the liquid surface shape estimated by the liquid surface shape estimation unit.

Abstract: An observation apparatus includes an acquisition unit that acquires positional information indicating a position of a bottom surface of a support for supporting an observation target, an imaging optical system that forms an optical image showing the observation target supported by the support on an image plane, a focus adjustment unit that adjusts a focal position of the imaging optical system based on the positional information acquired by the acquisition unit, and a control unit that performs control for matching an inclination of the image plane on which the optical image is formed to an inclination of an imaging surface of an imaging element based on the positional information acquired by the acquisition unit.

Abstract: Before an observation region of the imaging optical system reaches an observation position in a culture container, a vertical position of the culture container at the observation position is precedently detected by an auto-focus displacement sensor. In a case where an auto-focus control is performed on the basis of the position, an error between the precedently detected vertical position of the container at the observation position and a vertical position of the container at a time point when an observation region of the imaging optical system is scanned up to the observation position is acquired, and an objective lens is moved in an optical axis direction on the basis of the error.

Abstract: The observation device includes an imaging optical system that includes an imaging lens forming an image of an observation target in a cultivation container, an operating section that performs at least one of a first operation of changing a focal length of the imaging optical system, a second operation of moving the imaging lens in an optical axis direction, or a fourth operation of moving the container in the optical axis direction, a detection section that detects a vertical position of the cultivation container, and an operation controller that controls the operating section based on the vertical position of the cultivation container.

Abstract: A liquid surface in a culture vessel is irradiated with liquid-surface-measurement illumination light, and transmitted light that has passed through the liquid is detected by an imaging unit. A relative positional relationship between a focal plane of an image forming optical system and the culture vessel is changed, a detection signal for each position of the focal plane is obtained, and a liquid surface shape is estimated on the basis of the detection signal for each position of the focal plane. Then, on the basis of the estimated liquid surface shape, adjustment information for adjusting the optical characteristics of an adjustment optical system for adjusting refraction of light due to the liquid surface shape is acquired. After the optical characteristics of the adjustment optical system have been adjusted on the basis of the adjustment information, an image of a specimen is captured by irradiating the culture vessel with phase-contrast-measurement illumination light.

Abstract: There are provided an endoscope system, a processor device, an operation method, and a distance measurement device for accurately measuring the observation distance even if a colorant or residues are present in a subject. An endoscope system 10 includes a light source device 14, an endoscope 12, and an observation distance measurement unit 63. The light source device 14 emits signal light, which has a wavelength band absorbed by hemoglobin contained in the subject, to the subject. The endoscope 12 has an image sensor 48 that images the subject with reflected light of the signal light and outputs an image signal. The observation distance measurement unit 63 measures the observation distance based on the image signal.

Abstract: Before an observation region of an imaging optical system 14 reaches an observation position in the cultivation container 50, a vertical position of the cultivation container 50 at the observation position is precedently detected by an auto-focus displacement sensor. In a case where an objective lens is moved in an optical axis direction on the basis of the position, an error between the precedently detected vertical position of the stage 51 at the observation position and a vertical position of the stage 51 at a time point when the observation region of the imaging optical system 14 is scanned up to the observation position is acquired, and the objective lens is moved in the optical axis direction on the basis of the error.