Abstract: The present invention is directed to genome editing systems, reagents and methods for the treatment of hemoglobinopathies.

Abstract: Wave power generation device and sea farm are provided. The wave power generation device includes a flexible mat, a transmission module and an energy conversion module. The flexible mat has at least three vertices, and can be spread by outward tensional forces applied on the vertices. At least one of the vertices is connected with the transmission module. The energy conversion module is connected to the transmission module, to partially convert mechanical energy of the flexible mat produced under an action of wave surge into electrical energy. The flexible mat and the transmission module are cooperated to enable the flexible mat to be sufficiently spread to absorb the wave energy under the action of wave undulation of various frequencies and directions.

Abstract: Disclosed is a drive component for a camera module including a first carrier movably installed within a driver housing and adapted for receiving a first lens part therein, a second carrier movably installed at the first carrier and adapted for receiving a second lens part therein, wherein the first lens part and the second lens part define an optical axis, and employing a “parent-child” to drive the zoom camera module to achieve the optical performance of optical zoom and/or optical focus adjustment at a relatively faster speed.

Abstract: Embodiments of this application provide a phase shifter and a base station antenna. The phase shifter includes a fixing frame, a phase-shifting stripline, and a sliding dielectric. The fixing frame includes a guide rail. The phase-shifting stripline is fixed on the guide rail. The sliding dielectric is slidably connected to the guide rail, and the sliding dielectric is separated from the phase-shifting stripline by the guide rail. The guide rail can guide movement of the sliding dielectric relative to the phase-shifting stripline, helping improve smoothness of the movement of the sliding dielectric relative to the phase-shifting stripline. Because the sliding dielectric is separated from the phase-shifting stripline by the guide rail, and during the movement of the sliding dielectric relative to the phase-shifting stripline, the sliding dielectric does not rub against the phase-shifting stripline.

Abstract: An electronic device may include a communication circuit configured to perform communication via an ultra-wide band (UWB) band, and a processor. The processor may be configured to determine a first distance between the electronic device and an external electronic device based on first signals exchanged while the electronic device operates in a two-way ranging mode, switch from the two-way ranging mode to a one-way ranging mode in response to determining the first distance, determine a second distance between the electronic device and the external electronic device based on the first distance and second signals received from the external electronic device while the electronic device operates in the one-way ranging mode, and switch from the one-way ranging mode to the two-way ranging mode in response to determining that a specified condition related to distance between the electronic device and the external electronic device is satisfied.

Abstract: Disclosed is a tryptophan optical probe, a preparation method therefor and the use thereof. Disclosed is an optical probe, comprising a tryptophan-sensitive polypeptide or a functional variant thereof and an optically active polypeptide or a functional variant thereof, wherein the optically active polypeptide or the functional variant thereof is located in the sequence of the tryptophan-sensitive polypeptide or the functional variant thereof. Furthermore, disclosed are a method for preparing the above-mentioned probe and the use thereof in the detection of tryptophan.

Abstract: The anti-PTK7 (protein tyrosine kinase 7) antibodies, antigen-binding fragments thereof, and antibody-drug conjugate (ADC) derived therefrom; anti-TROP2 (trophoblast cell surface antigen 2) antibodies, antigen-binding fragments thereof, and antibody-drug conjugate (ADC) derived therefrom; and anti-PTK7/TROP2 (e. g., multispecific or bispecific) antibodies or antigen-binding fragments thereof, and antibody-drug conjugate (ADC) derived therefrom and uses thereof are disclosed.

Abstract: This disclosure relates to anti-CD40 (TNF Receptor Superfamily Member 5) antibodies, antigen-binding fragments, and the uses thereof.

Abstract: Provided are anti-HER3 (human epidermal growth factor receptor 3) and anti-MET antibodies, and the related anti-gen-binding fragments thereof, antibody-drug conjugate (ADC) derived therefrom, and the uses thereof.

Abstract: A method for planning a scanning path of a frequency-modulated LiDAR scanner, in which multiple boundary points of a polygonal scanning region are defined; a boundary direction is standardized; a scanning direction is defined by determining an included angle ? between a movement direction of a measurement light spot and an X-axis; a scan line spacing is defined; a scanning starting point is determined; a control point sequence is generated; and the control points is rotated by an angle of ?? about a centroid of the boundary points to output final path control points. An electronic device and a computer-readable storage medium for performing such method are further provided.

Abstract: This disclosure discloses a fault analysis method and apparatus, a compute device cluster, and a readable storage medium, and relates to the field of computer technologies. The method is applied to a cloud server. The cloud server is configured to run a plurality of services that have a call relationship. The method includes: obtaining a tag of a first service, where the first service is any one of the plurality of services; obtaining link call information of a related service of the first service based on the tag of the first service; and obtaining, based on the link call information, a topology diagram corresponding to the first service, and performing fault analysis on the first service based on the topology diagram corresponding to the first service.

Abstract: Methods, systems, devices, and non-transitory computer readable media for generating reformatted content are provided. The disclosed technology can include obtaining content data comprising content segments associated with audio-video content. Based on inputting the content data into machine-learned classification models, classes associated with the content segments can be determined. Based on inputting the content segments into content-specific machine-learned models, reformatted content data comprising reformatted content segments associated with text content or image content that is based on the features of the content segments can be generated. Each content segment can be inputted into a content-specific machine-learned model that is configured to generate a reformatted content segment based on the classes associated with the content segment. Query data comprising queries can be obtained and a reformatted content segment associated with the queries can be determined.

Abstract: A method for optimizing the transient performance of a blade pump involves creating initial design models for the blade pump and an impeller, as well as a full-flow simulation model for the blade pump startup process. Structural parameters of the impeller are selected as design variables. Based on the initial design model and the full-flow simulation model, transient numerical calculations during the startup process are conducted using CFD simulation software. The transient external characteristics during the startup process include transient head and transient efficiency. The transient head and transient efficiency during the startup process are processed, resulting in weighted average head and weighted average efficiency. The design variables are used as input parameters, with the weighted average head and weighted average efficiency as response values.

Abstract: This disclosure relates to antigen-binding protein constructs (e.g., bispecific antibodies or antigen-binding fragments thereof), wherein the antigen-binding protein constructs specifically bind to two different antigens (e.g., PD-1 and CD40).

Abstract: A parallax-based automatic focusing and focus-locking method for a light field microscopy system includes using the light field microscopy system to shoot at the position of the defocus distance of a sample to obtain four-dimensional phase space data, using cross-correlation to calculate the parallax of each view relative to a central view of the four-dimensional phase space data, and calculating a two-dimensional defocus coefficient matrix of the light field microscopy system based on the parallaxes and the defocus distance; using the light field microscopy system to shoot the sample at the current shooting distance to obtain the current two-dimensional parallax matrix of the sample; performing linear fitting on the two-dimensional parallax matrix S and the two-dimensional defocus coefficient matrix K to obtain the current defocus value of the sample; and adjusting the current shooting distance in real time according to the defocus value until focusing and/or focus locking is completed.

Abstract: It relates to anti-EGFR/MUC1 antibodies, and antibody drug conjugates derived therefrom, and the use thereof.

Abstract: The present invention relates to a telescopic ladder comprising a telescopic ladder section and a ladder foot section, wherein the telescopic ladder section comprises a rail that is configured to have a fit between at least two rungs, each rung of rail includes a rung, a bracket, and a rail tube, and the rail tube comprises a first arc edge plate, a straight edge plate, and a second arc edge plate. Compared with traditional circular tubes, this structure significantly improves the anti-torsion ability of rail tubes, and ensures the stability and safety of the ladder, and performs excellently especially under high load operating conditions.

Abstract: The method includes determining service information corresponding to the target tenant, where the service information indicates information about a service instance of the target service in the managed cluster; creating a gateway corresponding to the target tenant, where the gateway includes a traffic monitoring rule; determining a traffic processing rule corresponding to the target service, where the traffic processing rule is associated with a target monitoring rule in the traffic monitoring rule; and sending the service information, the target monitoring rule, and the traffic processing rule to a traffic proxy in a virtual private cloud of the target tenant, to cause the traffic proxy to perform service governance on the target service. A service governance rule of a tenant is sent to a proxy in a virtual private cloud of the tenant, to implement data isolation, and improve data security.

Abstract: An application running method includes a first container that is in a first container group loads bytecode in a first JAVA archive to obtain a second JAVA archive of an application, where the second JAVA archive includes first bytecode of a to-be-enhanced class in the application, the first container runs a first enhancement component, and the first bytecode is obtained by modifying, by the first enhancement component, bytecode of the to-be-enhanced class in the first JAVA archive in a process in which the first container loads the bytecode in the first JAVA archive; a second container in the first container group loads bytecode in the second JAVA archive to obtain a first loading result; and the second container runs the application based on the first loading result.

Abstract: An electronic device package comprises a conductive feature over a first surface of a package substrate, the conductive feature to couple to an integrated circuit die; a first dielectric layer on the conductive feature, the first dielectric layer having a first thickness and comprising silicon and nitrogen; a second dielectric layer over the first dielectric layer and having a second thickness different than the first thickness and comprising silicon and nitrogen; and a third dielectric layer over the second dielectric layer and comprising an organic material.