Patents by Inventor Yi Zhu

Yi Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Packaged RF power amplifier having a high power density
    Patent number: 10685927
    Abstract: A packaged RF power amplifier comprises an output network coupled to the output of a RF power transistor, which output network comprises a plurality of first bondwires extending along a first direction between the output of transistor and an output lead of the package, a series connection of a second inductor and a first capacitor between the output of the RF power transistor and ground, and a series connection of a third inductor and a second capacitor connected in between ground and the junction between the second inductor and the first capacitor. The first and second capacitors are integrated on a single passive die and the third inductor comprises a first part and a second part connected in series, wherein the first part extends at least partially along the first direction, and wherein the second part extends at least partially in a direction opposite to the first direction.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: June 16, 2020
    Assignee: Ampleon Netherlands B.V.
    Inventors: Johannes Adrianus Maria De Boet, Yi Zhu, Yuri Volokhine, Vittorio Cuoco, Albertus Gerardus Wilhelmus Philipus Van Zuijlen, Iordan Konstantlnov Sveshtarov, Josephus Henricus Bartholomeus Van der Zanden
  • ANTI-CD3 ANTIBODIES AND METHODS OF MAKING AND USING THEREOF
    Publication number: 20200157217
    Abstract: The applications provides the anti-CD3 monoclonal antibodies, antigen-binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to active CD3+ T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.
    Type: Application
    Filed: June 22, 2018
    Publication date: May 21, 2020
    Inventors: Ole OLSEN, Phil TAN, Dong XIA, David JELLYMAN, Brian KOVACEVICH, Bill BRADY, Blair RENSHAW, Zeren GAO, Yi ZHU
  • MULTI-SPECIFIC ANTIBODIES AND METHODS OF MAKING AND USING THEREOF
    Publication number: 20200157213
    Abstract: The application provides tri-specific antibody monomers having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a Fab domain, a Fc domain, and a second scFv domain at the C-terminal. In one embodiment, the first scFv domain, the Fab domain, and the second scFv domain each has a binding specificity against a different antigen.
    Type: Application
    Filed: June 22, 2018
    Publication date: May 21, 2020
    Inventors: Yi ZHU, Ole OLSEN, Dong XIA, David JELLYMAN, Katrina BYKOVA, Anne-Marie K. ROUSSEAU, Bill BRADY, Blair RENSHAW, Brian KOVACEVICH, Yu LIANG, Zeren GAO
  • MULTI-SPECIFIC ANTIBODIES AND METHODS OF MAKING AND USING THEREOF
    Publication number: 20200157224
    Abstract: The disclosure provides a tetra-specific antibody monomer having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a second scFv domain, a Fab domain, a Fc domain, and a third scFv at the C-terminal, wherein the first scFv domain, the second scFv domain, the Fab domain, and the third scFv domain each has a binding specificity against a different antigen. In one embodiment, the antigen is a tumor antigen, an immune signaling antigen, or a combination thereof. In one embodiment, the antigen includes CD19, CD3, CD137, 4-1BB, and PD-L1. Multi-specific antibodies comprising the disclosed tetra-specific antibodies are also provided.
    Type: Application
    Filed: June 22, 2018
    Publication date: May 21, 2020
    Inventors: Yi ZHU, Ole OLSEN, Dong XIA, David JELLYMAN, Katrina BYKOVA, Anne-Marie K. ROUSSEAU, Bill BRADY, Blair RENSHAW, Brian KOVACEVICH, Yu LIANG, Zeren GAO
  • ANTI-PD-1 ANTIBODIES AND METHODS OF MAKING AND USING THEREOF
    Publication number: 20200157219
    Abstract: The application provides anti-PD-1 monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.
    Type: Application
    Filed: June 22, 2018
    Publication date: May 21, 2020
    Inventors: Brian KOVACEVICH, Dong XIA, Anne E. JENSEN, Jonathan K. FALLEN, Blair RENSHAW, Jeffrey B. Adamo, Phil TAN, Zeren GAO, Yi ZHU
  • METHODS FOR DECENTRALIZED DIGITAL ASSET TRANSFER AND SMART CONTRACT STATE TRANSITION
    Publication number: 20200143366
    Abstract: Provided is a method for digital assets transfer or smart contract state transition on a distributed ledger using a snapshot chain that comprises a series of snapshot blocks linked by hash reference. The distributed ledger comprises a plurality of accounts, each account having an account chain comprising a series of blocks linked by hash reference. The global consensus of the distributed ledger is recorded in the snapshot chain.
    Type: Application
    Filed: November 17, 2018
    Publication date: May 7, 2020
    Inventors: Chunming Liu, Lingyong Zhang, Yi Zhu
  • METHODS FOR DECENTRALIZED DIGITAL ASSET TRANSFER AND SMART CONTRACT STATE TRANSITION
    Publication number: 20200143372
    Abstract: Provided is a method for digital assets transfer or smart contract state transition on a distributed ledger using a snapshot chain that comprises a series of snapshot blocks linked by hash reference. The distributed ledger comprises a plurality of accounts, each account having an account chain comprising a series of blocks linked by hash reference. The global consensus of the distributed ledger is recorded in the snapshot chain.
    Type: Application
    Filed: November 2, 2018
    Publication date: May 7, 2020
    Inventors: Chunming Liu, Lingyong Zhang, Yi Zhu
  • CYSTEINE MODIFIED ANTIBODY-DRUG CONJUGATE AND PREPARATION METHOD THEREOF
    Publication number: 20200129635
    Abstract: By inserting cysteine (C) into a heavy chain and/or a light chain of a target antibody at specific insertion site, and performing a site-specific conjugation through a free thiol group (—SH) from the site-specific inserted cysteine and a linker conjugated with a highly potent small molecule cytotoxin, a cysteine modified antibody-drug conjugate with good homogeneity is provided.
    Type: Application
    Filed: September 30, 2017
    Publication date: April 30, 2020
    Inventors: Yi ZHU, Yixi WANG, Shi ZHUO, Jie LI, Lan CHEN, Weili WAN, Yongguo YU
  • Safety belt central adjuster
    Patent number: 10576926
    Abstract: A safety belt central adjuster, which has a main body, a press plate and a connecting piece, wherein the press plate and the main body are connected in a hinged mode through the connecting piece, and the press plate can rotate around the connecting piece; at least one spring mechanism used for ensuring the tightening force of the press plate is arranged at the hinged joint of the press plate and the main body, and a ratchet part is arranged at the lower end of the press plate and provided with round sharp reverse teeth; the ratchet part disengages from the main body, and a channel allowing a safety belt to stretch therein is formed between the ratchet part and the main body.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: March 3, 2020
    Assignee: NINGBO SOTER SAFETY CO. LTD.
    Inventors: Hongchi Liu, Yi Zhu, Qinbing Ma
  • METHOD, APPARATUS, AND MEDIUM FOR CALCULATING CAPACITIES OF PHOTOVOLTAIC POWER STATIONS
    Publication number: 20200059101
    Abstract: The present disclosure provides a method, an apparatus, and a medium for calculating capacities of a plurality of photovoltaic power stations. The method includes: receiving a plurality of historical weather data sets from the plurality of weather monitoring stations; determining a scene year based on the plurality of historical weather data sets; receiving an actual generating capacity of each photovoltaic power station predicted by a power system dispatch center; extracting weather data of each photovoltaic power station in the scene year from the corresponding historical weather data set; obtaining an available generating capacity of each photovoltaic power station in the scene year based on the weather data; and determining a capacity of each photovoltaic power station in the scene year according to the actual generating capacity and the available generating capacity of each photovoltaic power station.
    Type: Application
    Filed: August 13, 2019
    Publication date: February 20, 2020
    Inventors: Jian ZHANG, Xin TIAN, Xueliang LI, Ning ZHANG, Jian WU, Long ZHAO, Yan WANG, Zhijie ZHENG, Hong MOU, Yuan WANG, Xiaoming LIU, Jie ZHANG, Xiaonan GAO, Jianing ZHANG, Dong LIU, Ying MOU, Shanjie JIA, Bo LI, Yi ZHU, Xiaohai GAO, Xin WEI, Jia WEI
  • Guard bond wires in an integrated circuit package
    Patent number: 10553543
    Abstract: An integrated circuit package is provided. The integrated circuit package comprises a first and second guard bond wire. The first guard bond wire has a first and second end coupled to ground. The second guard bond wire has a first and second end coupled to ground. The integrated circuit package further comprises a die. The die is mounted between the first and second guard bond wires such that the first and second guard bond wires distort a magnetic field between at least an input terminal and an output terminal of the die.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: February 4, 2020
    Assignee: Ampleon Netherlands B.V.
    Inventors: Vittorio Cuoco, Youri Volkhine, Yi Zhu, Josephus Van Der Zanden, Anna Walesieniuk
  • TREATING COGNITIVE DECLINE AND OTHER NEURODEGENERATIVE CONDITIONS BY SELECTIVELY REMOVING SENESCENT CELLS FROM NEUROLOGICAL TISSUE
    Publication number: 20200030323
    Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
    Type: Application
    Filed: September 26, 2019
    Publication date: January 30, 2020
    Inventors: Remi-Martin Laberge, Judith Campisi, Marco Demaria, Nathaniel David, James L. Kirkland, Tamar Tchkonia, Yi Zhu, Darren J. Baker, Jan M.A. van Deursen
  • Removing senescent cells from a mixed cell population or tissue using a phosphoinositide 3-kinase (PI3K) inhibitor
    Patent number: 10517866
    Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: December 31, 2019
    Assignees: Unity Biotechnology, Inc., Buck Institute for Research on Aging, Mayo Foundation for Medical Education and Research
    Inventors: Remi-Martin Laberge, James L. Kirkland, Tamar Tchkonia, Yi Zhu, Nathaniel David, Alain Philippe Vasserot, Darren J. Baker, Bennett G. Childs, Jan M. A. van Deursen
  • SANDBAG AND OPERATION METHOD AND SYSTEM OF THE SANDBAG
    Publication number: 20190388758
    Abstract: The present disclosure provides a sandbag, and an operation method and system of the sandbag, relating to the field of exercise and fitness. In the sandbag of the present disclosure, a bracket, a sandbag body provided on the bracket, a display screen provided on an outer surface of the sandbag body, a hitting detector provided on the outer surface of the sandbag body, a processor and a network module are provided, wherein the processor is electrically connected with the hitting detector, the display screen, and the network module respectively; the processor can detect hitting data of the user through the hitting detector, and acquire the network data through the network module, and control displaying of the display screen according to the hitting data and/or the network data, thus, the contents displayed are enriched, and the user experience is improved.
    Type: Application
    Filed: February 23, 2018
    Publication date: December 26, 2019
    Inventor: Yi ZHU
  • Compositions of matter for treatment of ophthalmic conditions by selectively removing senescent cells from the eye
    Patent number: 10478432
    Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: November 19, 2019
    Assignees: Unity Biotechnology, Inc., Buck Institute for Research on Aging, Mayo Foundation for Medical Education and Research
    Inventors: Remi-Martin Laberge, Judith Campisi, Marco Demaria, Nathaniel David, Alain Philippe Vasserot, James L. Kirkland, Tamar Tchkonia, Yi Zhu, Darren J. Baker, Bennett G. Childs, Jan M. A. van Deursen
  • Unit dose of an aryl sulfonamide that is effective for treating eye disease and averting potential vision loss
    Patent number: 10478433
    Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: November 19, 2019
    Assignees: Unity Biotechnology, Inc., Buck Institute for Research on Aging, Mayo Foundation for Medical Education and Research
    Inventors: Remi-Martin Laberge, Judith Campisi, Marco Demaria, Nathaniel David, Darren J. Baker, James L. Kirkland, Tamar Tchkonia, Yi Zhu, Jan M. A. van Deursen, Alain Philippe Vasserot, Bennett G. Childs
  • THERAPY FOR REMOVING SENESCENT CELLS AND TREATING SENESCENCE-ASSOCIATED DISEASE USING AN MDM2 INHIBITOR
    Publication number: 20190343832
    Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
    Type: Application
    Filed: July 10, 2019
    Publication date: November 14, 2019
    Inventors: Remi-Martin Laberge, Judith Campisi, Albert Davalos, Marco Demaria, Nathaniel David, Alain Philippe Vasserot, James L. Kirkland, Tamar Tchkonia, Jennifer Elisseeff, Chaekyu Kim, Okhee Jeon, Yi Zhu
  • LIGAND FOR ORPHAN NUCLEAR RECEPTOR NUR77 AND USES THEREOF
    Publication number: 20190330261
    Abstract: Provided are use of a compound of Formula I as a ligand of orphan nulear receptor Nur77, and in the prevention or treatment of a orphan nulear receptor Nur77 associated disease,
    Type: Application
    Filed: July 4, 2017
    Publication date: October 31, 2019
    Applicant: XIAMEN UNIVERSITY
    Inventors: Xiaokun ZHANG, Xiangzhi LIN, Ying SU, Zhiping ZENG, Mengjie HU, Qiang LUO, Yi ZHU, Alitongbieke GULIMIRAN
  • Parasol frame
    Patent number: D884335
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: May 19, 2020
    Assignee: Linhai Meiyang Parasol Industry Co., Ltd
    Inventors: Yi Zhu, Yingying Wang
  • Portable curler
    Patent number: D884968
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: May 19, 2020
    Assignee: SHENZHEN HUANMEI ELECTRONIC TECHNOLOGY CO., LTD
    Inventor: Yi Zhu