Abstract: The present invention provides a special drug conjugate having a hydrophilic acidic stabilization junction. Compared with a conjugate having a lower drug loading, due to the introduction of the acidic stabilization junction, the conjugate in the present invention can also have a higher drug loading (that is, each targeted reagent has more hydrophilic drug junctions), keeps a desired PK property and has a same or better activity in a body.

Abstract: Systems and methods for generating a furnishing plan for a property are disclosed. An exemplary system includes a communication interface configured to receive a floor plan of the property and a neural network model. The system further includes at least one processor configured to obtain structural data of the property based on the floor plan and learn furnishing information by applying the neural network model to the floor plan and the structural data. The furnishing information identifies one or more furnishing objects, positions of the respective furnishing objects placed in the floor plan, and dimensions of the respective furnishing objects. The at least one processor is also configured to generate the furnishing plan for the property based on the furnishing information.

Abstract: A plant protein snack with meat-like texture food product generally includes a plant based structured product having layered fibers that are cross-linked yet generally aligned along a longitudinal axis and that mimics the look and organoleptic properties of meat jerky products. Methods of making the food product are described.

Abstract: Provided are a method and an apparatus for displaying item information in a current space, an electronic device, and a non-transitory machine-readable storage medium. The method comprises: obtaining spatial data of a current position in a current space, and obtaining position data and information data of at least one item in the current space according to the spatial data; calculating a display priority of the at least one item in the current space according to the spatial data, the position data, and the information data; and displaying the information data of the at least one item according to the display priority. Through the method, the display priority of the information data of the at least one item in the current space are calculated, and then the information data of the at least one item in the current space is displayed according to the display priority, so that it is convenient for a user to directly view the information data of the at least one item in the current space.

Abstract: A bispecific tetravalent antibody comprising an IgG having a pair of heavy chains and a pair of light chains, and two scFv components being connected to either C or N terminals of the heavy or light chains. The bispecific tetravalent antibody may have a binding specificity for two different members of EGFR family.

Abstract: Disclosed is a non-natural amatoxin-type antibody conjugate, said conjugate similar to the natural amatoxin is linked to a biopharmaceutically acceptable salt with a target biomolecule so as to obtain stability in blood plasma, and efficiently kill tumor cells in cells.

Abstract: Provided is a nano grid protection device for a nano grid including a distributed power supply, a large power grid including the nano grid protection device, and a method for controlling the nano grid protection device. In an embodiment, the nano grid is connected with a bus through the nano grid protection device and a main grid is connected with the bus through a main grid protection device. In an embodiment, the nano grid protection device includes: a signal unit, configured to detect and send current information passing through the nano grid protection device, the current information including the magnitude and direction of the current; a controller, configured to determine, based upon the received current information, whether to send a trip signal or not; and an execution mechanism, configured to execute a trip operation of the nano grid protection device upon receiving the trip signal.

Abstract: A media file pushing method, a media file server, and a media file pushing system relate to the field of communications technologies and are configured to resolve a problem that a user cannot quickly obtain a media file satisfying a pushing requirement of the user. The method includes obtaining search information from a user, where the search information includes time information, and the time information indicates a requirement of the user on playback duration of a media file, determining playback content of the media file based on a preset content determining rule, obtaining at least one target media file satisfying the time information and the playback content from a media file resource library based on the time information and the playback content of the media file, and presenting the at least one target media file in a pushing interface.

Abstract: The application provides guidance and navigation control (GNC) proteins. In one embodiment, the guidance and navigation control (GNC) protein, comprising a binding domain for a T cell activating receptor, a binding domain for a tumor associated antigen, a bind domain for an immune checkpoint receptor, and a binding domain for a T cell co-stimulating receptor. The binding domain for the tumor associated antigen is not adjacent to the binding domain for the T cell co-stimulating receptor. In one embodiment, the binding domain for the T cell activating receptor is adjacent to the binding domain for the tumor associated antigen (TAA).

Abstract: Systems and methods for generating a furnishing plan for a property are disclosed. An exemplary system includes a communication interface configured to receive a floor plan of the property and a neural network model. The system further includes at least one processor configured to obtain structural data of the property based on the floor plan and learn furnishing information by applying the neural network model to the floor plan and the structural data. The furnishing information identifies one or more furnishing objects, positions of the respective furnishing objects placed in the floor plan, and dimensions of the respective furnishing objects. The at least one processor is also configured to generate the furnishing plan for the property based on the furnishing information.

Abstract: The application provides methods for generating a therapeutic composition. The method includes the steps of providing a cell material comprising a cytotoxic cell, incubating the cell material with a first GNC protein to provide an activated cell composition, wherein the activated cell composition comprises a first therapeutic cell, and formulating the activated cell composition to provide a therapeutic composition, wherein the therapeutic composition is substantially free of exogenous viral and non-viral DNA or RNA. The first GNC protein comprises a first cytotoxic binding moiety and a first cancer targeting moiety, wherein the first cytotoxic binding moiety has a specificity to a first cytotoxic cell receptor and is configured to activate the first cytotoxic cell, and wherein the first cancer targeting moiety has a specificity to a first cancer cell receptor. The first therapeutic cell comprises the first GNC protein bound to the cytotoxic cell through the first cytotoxic cell receptor.

Abstract: This invention discloses the first example of palladium(II)-catalyzed ?-C(sp3)-H iodination or arylation of a wide range of ketones by using a commercially available aminooxyacetic acid auxiliary. This L, X-type directing group overcomes the limitation of the transient directing group approach for -?C(sp3)-H functionalization of ketones. Practical advantages of this method include simple installation of the auxiliary without chromatography, exceptional tolerance of a-functional groups, double bonds and triple bonds and rapid access to diverse sterically hindered quaternary centers.

Abstract: Systems and methods for displaying a three-dimensional (3D) model of a real estate property are disclosed. An exemplary system may include a display device, a memory storing computer-readable instructions and at least one processor. The processor may execute the computer-readable instructions to perform operations. The operations may include determining a field of view (FOV) of a virtual observer of the 3D model based on a view point of the virtual observer in the 3D model. The FOV may cover a subset of the 3D model. The operations may also include determining, based on a floor plan corresponding to the 3D model, feature information of a functional space that at least partially fall within the FOV or connect to the subset of the 3D model covered by the FOV. The operations may further include controlling the display device to display the subset of the 3D model along with the feature information.

Abstract: The disclosure provides bispecific antibodies having the binding specificity to at least two of human CTLA4, PD-1 or PD-L1. In one embodiment, the bispecific antibody comprises IgG domains having heavy chains and light chains, and two scFv components being connected to either C-terminal of the heavy chains or N-terminal of the light chains, wherein the IgG domains have the binding specificity to a first antigen, wherein the scFv components have the binding specificity to a second antigen, and wherein the first antigen and the second antigen are different and are independently selected from a-CTLA4, ?-PD-1, and ?-PD-L1.

Abstract: A mesh network device includes a content repository including a first section to store original data and a second section to store cached data, and an application processor including a user space, kernel space, and an on-path data caching engine. The on-path data caching engine is to receive, from a second mesh network device, data frames via a data link layer of a TCP/IP mesh network. The data frames include audio or video content. The on-path data caching engine is further to store the data frames in a socket kernel buffer, determine that a third mesh network device is a destination for the data frames, and forward the data frames to the third mesh network device. The on-path data caching engine is to determine that the audio or video content is to be cached and asynchronously copy the audio or video content to the second section of the content repository.

Abstract: Provided are use of a compound of Formula I as a ligand of orphan nulear receptor Nur77, and in the prevention or treatment of a orphan nulear receptor Nur77 associated disease,

Abstract: Provided herein are methods and uses for treatment or prophylaxis of a senescent cell associated disease or disorder by administering a senolytic combination comprising dasatinib and quercetin or an analog thereof to a subject in need thereof. In certain embodiments, the senescent cell associated disease or disorder is a cardiovascular disease or disorder, inflanunatory disease or disorder, a pulmonary disease or disorder, a neurological disease or disorder, or a metabolic disease or disorder.

Abstract: Embodiments of present disclosure disclose a method for updating geomagnetic information performed at a computing device, which belong to the field of electronic technologies. The method includes: receiving target geomagnetic information and target location assistance information that are transmitted by a terminal during positioning; determining a target geographical location corresponding to the target location assistance information in a case that geomagnetic information corresponding to a current geographical location of the terminal is invalid; and updating geomagnetic information corresponding to the target geographical location according to the target geomagnetic information in a prestored correspondence between a geographical location and geomagnetic information. According to the embodiments of the present disclosure, efficiency of updating geomagnetic information can be improved.

Abstract: Network hardware devices organized in a wireless mesh network (WMN) in which one mesh network device includes a first radio and one or more additional radios coupled to an application processor. The application processor receives a request to stream content data to a client consumption device, via the first radio, and receives portions of the content data from multiple devices at different retrieval rates via the one or more additional radios. The application processor calculates an average retrieval rate for retrieving the first segments and the second segments, determines a desired streaming bitrate value, and determines an end time to complete transmission of a first portion to the client consumption device. The application processor transmits, via the first radio, the first portion such that at least one byte of the first portion is transmitted at the end time to complete transmission of the first portion.

Abstract: A bispecific tetravalent antibody comprising an IgG having a pair of heavy chains and a pair of light chains, and two scFv components being connected to either C or N terminals of the heavy or light chains. The bispecific tetravalent antibody may have a binding specificity for two different epitopes on HER2 receptor.