Abstract: A device is for opening or closing a DC circuit with at least one busbar. The device includes an electric switch for opening or closing the DC circuit; a fault current detector; a trigger unit and a precharging device. The electric switch opens the DC circuit via the trigger unit upon a fault current being detected by the fault current detector. Further, the precharging device restores the voltage on the busbar prior to closing the electric switch. The device further includes a control unit for automatically closing the electric switch after the pre-charging process.

Abstract: The disclosure provides a tetra-specific antibody monomer having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a Fab domain, a Fc domain, a second scFv domain, and a third scFv at the C-terminal, wherein the first scFv domain, the Fab domain, the second scFv domain, and the third scFv domain each has a binding specificity against a different antigen. In one embodiment, the antigen is a tumor antigen, an immune signaling antigen, or a combination thereof. Multi-specific antibodies comprising the disclosed tetra-specific antibodies are also provided.

Abstract: The application provides guidance and navigation control (GNC) proteins. In one embodiment, the GNC protein Comprises a T-cell binding moiety and a cancer-targeting moiety, wherein the T-cell binding moiety has a binding specificity to a T-cell receptor comprising CD3, CD28, PDL1, PD1, OX40, 4-1BB, GITR, TIGIT, TIM-3, LAG-3, CTLA4, CD40, VISTA, ICOS, BTLA, Light, NKp30, CD28H, CD27, CD226, CD96, CD112R, A2AR, CD160, CD244, CECAM1, CD200R, TNFRSF25 (DR3), or a combination thereof, and wherein the cancer targeting moiety has a binding specificity to a cancer cell receptor.

Abstract: The application provides the anti-PD-L1 monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.

Abstract: Disclosed in the present invention is a cysteine-modified antibody-toxin conjugate. The cysteine-modified antibody-toxin conjugate is characterized in that: the antibody is an antibody in which cysteine is inserted on a fixed point, and insertion sites of the cysteine comprising one or more of the following sites: a 110th site, a IIIth site and a 142th site of a light chain in a Kappa/?L light chain constant region, and a 254th site, a 255th site, a 258th, a 259th site, a 354th site, a 355th site, a 357th site, a 378th site, a 379th site, a 386th site, a 387th site or a 410th site of a heavy chain of a heavy chain constant region of an IgG antibody.

Abstract: Embodiments of present disclosure disclose a method for updating geomagnetic information performed at a computing device, which belong to the field of electronic technologies. The method includes: receiving target geomagnetic information and target location assistance information that are transmitted by a terminal during positioning; determining a target geographical location corresponding to the target location assistance information in a case that geomagnetic information corresponding to a current geographical location of the terminal is invalid; and updating geomagnetic information corresponding to the target geographical location according to the target geomagnetic information in a prestored correspondence between a geographical location and geomagnetic information. According to the embodiments of the present disclosure, efficiency of updating geomagnetic information can be improved.

Abstract: A light condensing device for inspecting the quality inside fruits and vegetables, resolving problems in which manually holding fruits for inspection is inefficient and cannot be used in large-scale fruit packaging production. The device comprises a housing, a halogen lamp, a diaphragm, a plano-convex lens support a first plano-convex lens, a reflector lens fixing plate, a reflector, a plano-convex lens fixing plate, and a second plano-convex lens. The housing is a sealed and non-transparent housing. The halogen lamp is fixedly disposed at a left end of the housing, and extends into an inner portion of the housing. A pluggable diaphragm is disposed at the right side of the halogen lamp, and is used to guide a lighting direction of the halogen lamp. The diaphragm passes through the inner portion of the housing. The plano-convex lens support is fixedly disposed inside the housing at the right side of the diaphragm.

Abstract: Provided is a method of digital asset transfer on a distributed ledger operated on a network, wherein the distributed ledger comprises a plurality of users, each user having a transaction chain comprising a series of transactions linked by hash reference, wherein the network comprises a plurality of nodes each having a processor. The global consensus of the distributed ledger is recorded in a snapshot chain.

Abstract: Provided are a method and an apparatus for displaying item information in a current space, an electronic device, and a non-transitory machine-readable storage medium. The method comprises: obtaining spatial data of a current position in a current space, and obtaining position data and information data of at least one item in the current space according to the spatial data; calculating a display priority of the at least one item in the current space according to the spatial data, the position data, and the information data; and displaying the information data of the at least one item according to the display priority. Through the method, the display priority of the information data of the at least one item in the current space are calculated, and then the information data of the at least one item in the current space is displayed according to the display priority, so that it is convenient for a user to directly view the information data of the at least one item in the current space.

Abstract: A bispecific tetravalent antibody comprising an IgG having a pair of heavy chains and a pair of light chains, and two scFv components being connected to either C or N terminals of the heavy or light chains. The bispecific tetravalent antibody may have a binding specificity for two different members of EGFR family.

Abstract: The application provides anti-ROR1 monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.

Abstract: Example embodiments relate to power amplifiers with decreased RF return current losses. One embodiment includes a RF power amplifier package that includes a semiconductor die, an input lead, first bondwire connections, second bondwire connections, and a plurality of shields. The semiconductor die includes an RF power transistor that includes output bond pads, input bond pads, a plurality of input fingers, and a plurality of output fingers. Further, each shield of the plurality of shields is arranged in between a respective input finger of the plurality of input fingers and a respective output finger of the plurality of output fingers and extending along with said respective input finger and output finger. In addition, each shield of the plurality of shields is connected to a ground terminal of the RF power transistor. The input fingers, output fingers, and shields are formed using a metal layer stack of multiple metal layers.

Abstract: The present disclosure provides a method, an apparatus, and a medium for calculating capacities of a plurality of photovoltaic power stations. The method includes: receiving a plurality of historical weather data sets from the plurality of weather monitoring stations; determining a scene year based on the plurality of historical weather data sets; receiving an actual generating capacity of each photovoltaic power station predicted by a power system dispatch center; extracting weather data of each photovoltaic power station in the scene year from the corresponding historical weather data set; obtaining an available generating capacity of each photovoltaic power station in the scene year based on the weather data; and determining a capacity of each photovoltaic power station in the scene year according to the actual generating capacity and the available generating capacity of each photovoltaic power station.

Abstract: The application provides anti-4-1BB monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.

Abstract: Systems and methods for generating a remodeling plan for a property are disclosed. An exemplary system includes a communication interface configured to receive a floor plan of the property and a remodeling preference. The system further includes at least one processor configured to obtain structural data of the property based on the floor plan and obtain a neural network model based on the remodeling preference. The neural network model is trained using sample floor plans and sample remodeling data for the remodeling preference. The at least one processor is further configured to learn structural remodeling information based on the floor plan and the structural data using the neural network model. The at least one processor is also configured to generate the remodeling plan for the property based on the structural remodeling information. The remodeling plan identifies one or more structures in the floor plan for remodeling.

Abstract: Systems and methods for visualizing furnishing objects in a property are disclosed. An exemplary system includes a communication interface configured to receive a depth image of an interior space of the property captured by a 3D scanner and the depth image includes one or more existing furnishing objects in the interior space. The system further includes at least one processor configured to remove at least one existing furnishing object from the depth image, leaving at least one hole in the depth image corresponding to where the removed existing furnishing object used to be. The at least one processor is further configured to restore the depth image by filling the at least one hole in the depth image with a scene of the interior space that was blocked by the removed existing furnishing object, using a first neural network model trained with an image inpainting algorithm.

Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

Abstract: The disclosure relates to a high-bioactivity black dry apple chip and a processing technology thereof. The processing process is as follows: fresh fruits?sorting?peeling?slicing?fermenting?drying?packaging?black dry apple chips. According to the disclosure, a high-temperature Bacillus subtilis fermentation broth atomization spray technology is adopted to atomize the processed apple slices under the condition of 60° C.-80° C., the cut apple slices are irradiated with 60 Coy rays at a dose of 4 kGy to promote carbonyl ammonia reaction so as to make apple slices generate burnt black. According to the disclosure, Bacillus subtilis antimicrobial peptide solution is sprayed so as to utilize its bacteriostatic function to avoid pathogen infection during shelf life.

Abstract: The disclosure relates to an appetizing and summer heat relieving tangxin raw cider and a high-efficiency deep processing technology thereof. The high-efficiency deep processing technology comprises the following steps: (1) preparing raw pulp; (2) detoxifying patulin; (3) inoculating and precisely fermenting; (4) performing enzymolysis of residues; (5) clarifying and filtering; (6) ageing; and (7) canning after adsorbing and clarifying. According to the disclosure, aiming at a phenomenon that cider is muddy after being stored, it is solved by adsorption with a multi-stimuli responsive nano fiber modified resin. Exterior stimuli include change in environment temperature or acidity-basicity (pH value), light, electric field, magnetic field or specific molecules. In response to exterior stimuli, nano fiber may include physicochemical properties such as size, hydrophilicity and hydrophobicity, refractive index, transmittance, mechanical strength, color or conductivity.