Abstract: The current disclosure provides polypeptide, nucleic acid, compositions, and methods for treating or preventing CRS in patients in need thereof, particularly for those receiving an immunotherapy, such as a cancer immunotherapy, that may provoke a CRS response. Accordingly, aspects of the disclosure relate to a chimeric binding polypeptides comprising a heavy chain variable region comprising CDR1, CDR2, and CDR3 attached by a heterologous linker to a light chain variable region comprising CDR4, CDR5, and CDR6.

Abstract: Provided is a method for analyzing a tissue specimen, including treating a tissue specimen with an aqueous clearing agent and with at least two fluorescent probes to obtain a cleared and labeled tissue specimen; imaging the cleared and labeled tissue specimen to generate a three-dimensional (3D) image of the tissue specimen; preparing a stained tissue section from the cleared and labeled tissue specimen; capturing a reference two-dimensional (2D) image of the stained tissue section; matching the reference 2D image with the 3D image to extract from the 3D image a series of 2D image slices including a corresponding 2D image slice that corresponds to the reference 2D image; and determining at least one pathological score for each of the series of 2D image slices and reporting the presence or absence and the extent of the disease based on the pathological scores. The method can improve the accuracy of histopathologic diagnosis.

Abstract: A peptide-imprinted conductive polymer and use thereof is provided, especially a peptide-imprinted conductive polymer including conductive polymer monomer(s), two-dimensional (2D) material(s), and a small peptide fragment of ?-synuclein as template. The peptide-imprinted conductive polymer has high sensibility, detects ?-synuclein at low concentrations, thus allowing early diagnosis and treatment of Parkinson's disease.

Abstract: The disclosure provides a clearing composition and a method utilizing the clearing composition for rendering a biological sample transparent. The clearing composition includes a RI matching material, a permeating agent including a surfactant, at least two labeling materials, and a solvent. The sample rendering method includes the steps of: (a) fixing a biological sample with a fixative solution; (b) embedding the biological sample into an embedding material; (c) immersing a biological sample in the clearing composition so the sample is permeated by the cleaning composition; and (d) mounting, by a mounting solution, the permeated biological sample.

Abstract: A system and method for creating, managing, and displaying packs of 3D digital collectibles comprising a virtual, three dimensional, n-sided structure including a digital media file or set of digital media files representing an event rendered on a representation of a first surface thereof, and data relating to the event rendered on at least a second surface thereof, where the digital media file may be a video clip of the event that can be played automatically via a media player associated with the display. The system may provide a graphical user interface that displays a set of user tools to interact with the packs of 3D digital collectibles and to display the 3D digital collectibles of the packs and serially play the digital media files of the 3D digital collectibles.

Abstract: A system and method for creating, managing, and displaying 3D digital collectibles comprising a virtual, three dimensional, n-sided structure including a digital media file or set of digital media files representing an event rendered on a representation of at least a first surface thereof, and data relating to the event rendered on at least a second surface thereof and other content on one or more other surfaces, where the digital media file may be video clip of the event that can be played automatically via a media player associated with the display.

Abstract: A system and method for creating, managing, and displaying 3D digital collectibles comprising a virtual, three dimensional, n-sided structure including a digital media file or set of digital media files representing an event rendered on a representation of at least a first surface thereof, and data relating to the event rendered on at least a second surface thereof and other content on one or more other surfaces, where the digital media file may be video clip of the event that can be played automatically via a media player associated with the display.

Abstract: A gas sensor network system provides near real-time monitoring of fugitive emissions of VOC compounds in chemical plants and facilities. The present disclosure provides a sensor placement method which determines where to place sensors within a facility. The sensor placement method includes obtaining plant layout, gas composition, meteorological conditions and/or other types of information regarding a facility, determining the types of gas and ancillary sensors needed, and generating the minimum detection distances required based on the sensitivities of the sensors to the gas compounds involved. And, then calculating the minimal number of sensors required for each sensor type with optimized sensor locations to ensure best coverage of potentially leaking components within the facility.

Abstract: An integrated control management system includes an input output device. The input output device includes a database, a memory module, a first processing module, and a second processing module. The memory module receives and stores a plurality of integrated control commands, and one of the integrated control commands is generated based on a hardware control command for setting a hardware control transmitted by another input and output device. The first processing module reads the integrated control command from the memory module and obtains the hardware control data from the integrated control command. The first processing module updates the hardware control data to the database. The second processing module reads the database and updates the hardware control data stored in the database to another database in another input output device. The second processing module sets the hardware control based on the hardware control data stored in the database.

Abstract: The present disclosure provides a method for preparing a hydrogel composition with thermos-sensitive and ionic reversible properties and the hydrogel composition prepared by the method. Related application products of the hydrogel composition of the present disclosure include wound dressings, drug carriers, three-dimensional cellular scaffolds, soluble microspheres, and cell capture and release systems, wherein the hydrogel composition with thermos-sensitive and ionic reversible properties has good in vitro and in vivo stability and high biocompatibility, and is non-toxic. The hydrogel composition can be removed and replaced by washing with metal chelating aqueous solution at low temperature.

Abstract: A slurry solution for a Chemical Mechanical Polishing (CMP) process includes a wetting agent, a stripper additive that comprises at least one of: N-methyl-2-pyrrolidone (NMP), dimethyl sulfoxide (DMSO), sulfolane, and dimethylformamide (DMF), and an oxidizer additive comprising at least one of: hydrogen peroxide (H2O2), ammonium persulfate ((NH4)2S2O8), peroxymonosulfuric acid (H2SO5), ozone (O3) in de-ionized water, and sulfuric acid (H2SO4).

Abstract: An electronic device is provided. The electronic device includes an optical sensing module that includes an optical sensor array. The optical sensor array includes at least one optical sensor, at least one transparent layer disposed on the optical sensor array, and a microlens array. The microlens array includes at least one microlens and is disposed on the transparent layer.

Abstract: Structures including a passive device and methods of forming such structures. Multiple fins are positioned on a substrate, and an interconnect structure is positioned over the substrate. The fins contain a polycrystalline semiconductor material, and the interconnect structure includes a passive device that is positioned over the fins. The passive device may be, for example, an inductor or a transmission line.

Abstract: Asymmetric hollow fiber membranes, membrane contactors, and related production and use methods. The asymmetric hollow fiber membranes include a porous substrate having a multiplicity of pores, the porous substrate including at least a first semi-crystalline thermoplastic polyolefin copolymer derived by polymerizing at most 3 wt. % of linear or branched alpha olefin monomers with at least 97 wt. % of 4-methyl-1-pentene monomer. The asymmetric hollow fiber membranes also include a skin layer overlaying the porous substrate, the skin layer including a second semi-crystalline thermoplastic polyolefin copolymer derived by polymerizing at least 2 wt. % of linear or branched alpha olefin monomers with at most 98 wt. % of 4-methyl-1-pentene monomer. The skin layer is less porous than the porous substrate and forms an outer surface of the asymmetric hollow fiber membrane, while the porous substrate forms an inner surface of the hollow fiber membrane. The skin layer is preferably nonporous.

Abstract: A system and method for creating, managing, and displaying 3D digital collectibles comprising a virtual, three dimensional, n-sided structure including a digital media file or set of digital media files representing an event rendered on a representation of at least a first surface thereof, and data relating to the event rendered on at least a second surface thereof and other content on one or more other surfaces, where the digital media file may be video clip of the event that can be played automatically via a media player associated with the display.

Abstract: The present invention discloses an ?-synuclein sensing film, a manufacturing method and a use thereof. The ?-synuclein sensing film comprises a base plate and plural ?-synuclein sensing polymers polymerized on the base plate. Each of the plural ?-synuclein sensing polymers has plural ?-synuclein detection holes on a surface thereof. The plural ?-synuclein sensing polymers are manufactured by electropolymerization, and the plural ?-synuclein detection holes are imprinted by an ?-synuclein peptide. A sample to be tested can be applied to the ?-synuclein sensing film for detecting the ?-synuclein therein.

Abstract: A hierarchical control method for an island power grid energy storage system for increasing new energy generation fluctuation is disclosed. The method includes implementing a rolling dispatch method based on an idea of model predictive control; comprehensively considering a response capability of the energy storage system to grid-wide economic dispatch instructions and life loss of energy storage lithium batteries, and constructing an objective function of an intraday control model of the energy storage system with economic optimization; and constructing, on a basis of satisfying the objective function of the intraday control model, a real-time control model of the energy storage system and solving the model, and determining charge and discharge plans of a lithium battery energy storage system and a supercapacitor energy storage system.

Abstract: The present invention relates to a composition comprising an amino acid-modified polymer, a carboxypolysaccharide, and may further include a metal ion for anti-adhesion and vector application. More specifically, the invention relates to a thermosensitive composition having enhanced mechanical and improved water-erosion resistant properties for efficiently preventing tissue adhesions and can serve as a vector with bio-compatible, bio-degradable/absorbable, and in-vivo sustainable properties.

Abstract: Hollow fiber membranes, membrane contactors, and related production and use methods. The membranes include a substrate having a multiplicity of pores and a skin layer overlaying the porous substrate. The porous substrate includes a first semi-crystalline thermoplastic polyolefin (co)polymer resin and a nucleating agent in an amount effective to achieve nucleation. The skin layer includes a second semi-crystalline thermoplastic polyolefin (co)polymer resin derived by polymerizing at most 98 wt. % of 4-methyl-1-pentene monomer with at least 2 wt. % of linear or branched alpha olefin monomers. Preferably, the first thermoplastic polyolefin (co)polymer is different from the second thermoplastic polyolefin (co)polymer. The skin layer is less porous than the porous substrate and forms an outer surface of the hollow fiber with the porous substrate forming an inner surface. The hollow fibers are formed by co-extruding the porous substrate resin and the skin layer resin through an annular die.