Abstract: A gate structure includes a substrate divided into an N-type transistor region and a P-type transistor region. An interlayer dielectric covers the substrate. A first trench is embedded in the interlayer dielectric within the N-type transistor region. A first gate electrode having a bullet-shaped profile is disposed in the first trench. A gate dielectric contacts the first trench. An N-type work function layer is disposed between the gate dielectric layer and the first gate electrode. A second trench is embedded in the interlayer dielectric within the P-type transistor region. A second gate electrode having a first mushroom-shaped profile is disposed in the second trench. The gate dielectric layer contacts the second trench. The N-type work function layer is disposed between the gate dielectric layer and the second gate electrode. A first P-type work function layer is disposed between the gate dielectric layer and the N-type work function layer.

Abstract: The present invention relates to novel use of koumine, an alkaloid monomer from Gelsemium elegans Benth., or a pharmaceutically acceptable salt thereof, and more particularly to use of koumine or its pharmaceutically acceptable salt in the preparation of a medicament for the treatment of inflammatory bowel disease.

Abstract: A semiconductor device includes a magnetic tunneling junction (MTJ) on a substrate, a first spacer on one side of the of the MTJ, a second spacer on another side of the MTJ, a first metal interconnection on the MTJ, and a liner adjacent to the first spacer, the second spacer, and the first metal interconnection. Preferably, each of a top surface of the MTJ and a bottom surface of the first metal interconnection includes a planar surface and two sidewalls of the first metal interconnection are aligned with two sidewalls of the MTJ.

Abstract: The present invention discloses a Fe—Al-based metal porous membrane and a preparation method thereof, which relate to the technical field of industrial gas-solid and liquid-solid separation and purification, and mainly address problems in the prior art, such as cracking-prone and peeling of a membrane layer of an existing Fe—Al-based metal porous membrane during its preparation and use. The preparation method of the present invention comprises the steps of: adding a Fe—Al-based metal powder and a metal fiber powder into an organic-additive-added water-based solvent, and mixing them into a slurry; casting the slurry, through a casting machine, to form a membrane green body on a metal substrate layer, and letting it dry; and placing the dried membrane green body in a sintering furnace, to remove organic substances and perform high-temperature sintering and predetermined-temperature reaction synthesis.

Abstract: Disclosed herein are humanized antibodies, antigen-binding fragments thereof, and antibody conjugates, that are capable of specifically binding to certain biantennary Lewis antigens, which antigens are expressed in a variety of cancers. The presently disclosed antibodies are useful to target antigen-expressing cells for treatment or detection of disease, including various cancers. Also provided are polynucleotides, vectors, and host cells for producing the disclosed antibodies and antigen-binding fragments thereof. Pharmaceutical compositions, methods of treatment and detection, and uses of the antibodies, antigen-binding fragments, antibody conjugates, and compositions are also provided.

Abstract: A positioning system and a positioning method based on radio frequency identification techniques (RFID) are provided. The positioning system includes in-vehicle devices, RFID readers and a server. The in-vehicle devices each includes a positioning device, an image capturing device and an image recognition module. The positioning device obtains a positioning location. The image capturing device captures a driving image. The image recognition module identifies adjacent vehicles, adjacent license plate information, and road attributes, and calculates relative location information. Each of the RFID readers reads a vehicle tag of one of the vehicles passing by, so as to mark a reference vehicle and generate reference vehicle information. A positioning adjustment module of the server determines whether the target vehicle is a reference vehicle, has been the reference vehicle or is a non-reference vehicle, and adjusts the positioning location of the target vehicle in different ways, accordingly.

Abstract: A semiconductor device includes a magnetic tunneling junction (MTJ) on a substrate, a first spacer on one side of the of the MTJ, a second spacer on another side of the MTJ, a first metal interconnection on the MTJ, and a liner adjacent to the first spacer, the second spacer, and the first metal interconnection. Preferably, each of a top surface of the MTJ and a bottom surface of the first metal interconnection includes a planar surface and two sidewalls of the first metal interconnection are aligned with two sidewalls of the MTJ.

Abstract: This application provides a data transmission method. The method includes: receiving a first PDCCH, where the first PDCCH includes first DCI, the first DCI indicates a first resource, and the first resource is used to carry first uplink data; determining a first time period or a second time period, where the first time period includes a time period for monitoring a second PDCCH, and the second time period does not include the second PDCCH; and monitoring the second PDCCH based on the first time period or the second time period.

Abstract: Provided are a display panel and a display device. The display panel includes a display region and a non-display region. The display region surrounds at least part of the non-display region. The non-display region includes an element disposition region and a bank disposition region surrounding at least part of the element disposition region. The bank disposition region is provided with a bank. The display panel includes a substrate, the bank is disposed on a side of the substrate; a light-emitting layer located on a side of the bank facing away from the substrate and including a first light-emitting portion located in the bank disposition region; and a first light-shielding structure located in the bank disposition region and on a side of the first light-emitting portion facing the substrate. The first light-emitting portion and the first light-shielding structure at least partially overlap along the thickness direction of the display panel.

Abstract: The invention provides a suspension modifier directly added into fracturing fluid for real-time proppant modification during fracturing and the application thereof, relating to the field of oil and gas production technologies. The suspension modifier is a controlled release nanoemulsion and comprises surface hydrophobic modifier, surfactant, cosurfactant and water. The suspension modifier is directly added into clear-water or active-water fracturing fluid while the proppant is added into water. After stirring, the suspension modifier is capable of self-assembling and being adsorbed on the proppant surface, so that the proppant surface becomes hydrophobic and aerophilic. The invention no longer requires the proppant to be pretreated, and the bubble-suspended proppant can be obtained directly by adding the suspension modifier to the clear-water or active-water fracturing fluid, and meanwhile adding the proppant to the fracturing fluid.

Abstract: Carbamate and beta-amino acid urea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used for imaging cells and tumors that express PSMA or for cancer radiotherapy. These compounds also can comprise a fluorescent dye and be used for imaging cells and tumors that express PSMA or for photodynamic therapy.

Abstract: The present invention provides a method of preparing a recycled cementitious material by a phosphogypsum-assisted carbon sequestration pretreatment process. The method includes: (1) placing 100 mass parts of phosphogypsum, 1 to 2 mass parts of grinding aid, 10 to 20 mass parts of sodium-containing alkali component, 150 to 300 mass parts of zirconia balls, and 150 to 300 mass parts of water into a wet grinding tank for wet grinding. After 10 min to 30 min of wet grinding, introducing CO2 at a flow rate of 1.5 to 2.2 mass parts/min to keep a temperature of a wet grinding slurry below 40° C. When the wet grinding slurry reaches pH=10, ending the wet grinding and sieving out a wet grinding slurry; (2) mixing the wet grinding slurry with 700 to 1000 mass parts of slag and 100 to 350 mass parts of water to obtain a recycled cementitious material.

Abstract: The present disclosure provides methods and compositions for the treatment of cancer using an ACAT1 inhibitor in combination with an immune checkpoint inhibitor. The immune checkpoint inhibitor may inhibit the programmed cell death protein 1 (PD-1), programmed death-ligand 1 (PD-L1), cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), lymphocyte-activation protein 3 (LAG-3), or combinations thereof. The ACAT1 inhibitor may be avasimibe, pactimibe, or purpactins, without limitation.

Abstract: A system for assessing extubation includes a respiratory assistance device, an artificial intelligence platform, and a hospital information system. The respiratory assistance device is adapted to communicate with a trachea of a patient. The artificial intelligence platform includes a prediction module. A method for assessing extubation includes the following steps. Measured values of respiratory parameters of the patient are recorded by the respiratory assistance device. The recorded times and the measured values of the respiratory parameters corresponding to each of the recording times are transmitted to the artificial intelligence platform. The prediction module analyzes the measured values of respiratory parameters within a predetermined time period according to a prediction model to generate a prediction result. The prediction result is transmitted to the hospital information system and is recorded into a medical record of the patient.

Abstract: A Cu-based alloy according to the present invention comprises 1.0-2.0 wt % Cr, 0.5-1.5 wt % Nb, 0.1-0.5 wt % Zr, and balance Cu. The alloy has a matrix and grain boundaries, and has Cr2Nb precipitates within the grain boundaries and at least one selected from the group consisting of CuZr and Cr precipitates in the grain matrix. The CuZr precipitates can be at least one selected from the group consisting of Cu5Zr and Cu51Zr14 precipitates. A method of making a CuCrNbZr alloy is also disclosed.

Abstract: Methods of increasing sIgA levels in an individual's oral cavity are disclosed. The methods comprise applying effective amounts of zinc oxide, zinc citrate, and arginine Methods of increasing the concentration of sIgA in the individual's mucosa pellicle in the oral cavity are disclosed. Methods of increasing phagocytotic activity of phagocytotic cells in the individual's oral cavity are also disclosed. In addition, methods of increasing levels of ?-Defensin 1 in the individual's oral cavity are disclosed.

Abstract: The present invention relates generally to glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a spacer containing ((2-oxoethyl)thio)). In an aspect the invention provides oxo-eT linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a ((2-oxoethyl)thio) spacer having the formula (I): wherein: A is a group (C?X)m wherein X is S or O and m is 0 or 1; B is a bond, O, or CH2; and when m is 0, B can also be (C?O); R is a C2-C16 alkylene, C2-C16 heteroakylene, NH—C(?O)—C2-C16 alkylene, or NH—C(?O)—C2-C16 heteroakylene, wherein said alkylene and heteroalkylene are optionally substituted by 1, 2 or 3 groups independently selected from COOR? where R? is selected from H, methyl, ethyl or propyl. The invention further relates to immunogenic compositions comprising such glycoconjugates, and to methods for the preparation and use of such glycoconjugates and immunogenic compositions.

Abstract: The present disclosure provides compositions that enable sustained release of a small molecule tyrosine kinase inhibitor, such as axitinib from a bioerodible polyester polymer implant for the treatment of disease. The composition is especially suitable for treating ophthalmic indications, such as neovascular age related macular degeneration and diabetic macular edema, by intravitreal injection of the implant. The implant is designed to be pre-loaded into a small diameter needle and injected via self-sealing scleral needle penetration at the pars plana. Small molecule tyrosine kinase inhibitors may be released from the implants over a period of one week to three years.

Abstract: The present disclosure provides a method for quantitative evaluation on a sensitivity of a shale oil and gas reservoir to injected fluids. The method includes the following steps: (I) preparation of rock samples; (II) quantitative evaluation on sensitivities of a shale porosity and a bedding fracture permeability to an injected fluid; and (III) quantitative evaluation on a sensitivity of a shale matrix permeability to an injected fluid. A method for comprehensive evaluation on a sensitivity of a shale oil and gas reservoir to injected fluids is innovatively provided based on the nuclear magnetic resonance testing technology with two basic physical property parameters: porosity and permeability. The method realizes quantitative evaluation on sensitivities of pores of different sizes and matrix of shale and a bedding fracture permeability to injected fluids, and realizes quantitative and accurate evaluation on a sensitivity of a shale oil and gas reservoir to injected fluids.

Abstract: Some embodiments relate to a roofing membrane. The roofing membrane comprises a scrim. The scrim has a top surface and a bottom surface. The roofing membrane comprises a cap layer on the top surface of the scrim. The cap layer comprises a first non-styrenic polypropylene polymer, a first polypropylene impact copolymer, and a first olefin block copolymer. The roofing membrane comprises a core layer on the bottom surface of the scrim. The core layer comprises a second non-styrenic polypropylene polymer, a second polypropylene impact copolymer, and a second olefin block copolymer. The roofing membrane is configured to prevent migration of at least one oil from a layer to the roofing membrane. Some embodiments relate to a roofing structure comprising the roofing membrane, a method for installing the roofing membrane, and the like.