Abstract: The inventors disclose a 1.95 ? crystal structure of the MR ligand binding domain containing a single C808S mutation bound to a corticosterone and the fourth LXXLL motif of steroid receptor coactivator-1 (SRC1-4). The inventors demonstrate that SRC1-4 is the most potent MR-binding motif and mutations that disrupt the MR/SRC1-4 interactions abolish the ability of the full-length SRC1 to coactivate MR. The structure also reveals a compact steroid binding pocket with a unique topology that is primarily defined by key residues of helices 6 and 7. Also described are novel ligands for MR, methods for screening for and designing novel MR ligands, and methods for treating MR-related diseases.

Abstract: A dual panel display has a housing, a first display panel, a second display panel, and a backlight module positioned between the first display panel and the fixing face of the housing. The backlight module includes a light guide panel, a light source, at least a transflective film and at least an optical property enhancement film between the light guide panel and the second display panel. The transflective film is positioned between the light guide panel and the fixing face for reflecting a part of light from the light guide sheet so that the part of light passes back into the light guide panel.

Abstract: A dual panel display has a backlight module, a first display panel, a second display panel, and a plurality of reflective polarizers deposited between the first light-exit surface and the first display panel or the second light exit surface and the second display panel of the light guide plate in the backlight module.

Abstract: A method and system for processing Doppler signal gaps is disclosed. The method comprising the steps of: receiving Doppler signals during Doppler signal acquisition to obtain data of in-phase (I) component and quadrate (Q) component signals of the Doppler signals; receiving interruption of the Doppler signals; estimating the data of the Doppler signals interrupted in said gap period filling the interrupted Doppler signals with the data of the estimated Doppler signals so that the data of the I and Q component signals in said gap period are filled to form a continuous output; and generating Doppler spectrum data or Doppler sound based on the data of the filled I and Q component signals.

Abstract: A method and system for detecting spectral Doppler blood flow velocity are disclosed. The method comprises the steps of: obtaining Doppler signals of the flow by demodulating, filtering, and analog-to-digital converting RF ultrasonic echoes; analyzing the spectrum of the Doppler signals to obtain each of the power spectral lines of the Doppler signal varying with time; determining a threshold; and determining the frequency shift parameters or the blood flow velocity corresponding to the current power spectral line based on the threshold and the current power spectral line.

Abstract: The 1.5 ? crystal structure of the orphan nuclear receptor steroidogenic factor 1 (SF-1) ligand binding domain in complex with an LxxLL motif from a co-regulator protein is disclosed. The structure reveals the presence of a phospholipid ligand in a surprisingly large pocket (˜1600 ?3), with the receptor adopting the canonical active conformation. The bound phospholipid is readily exchanged and modulates SF-1 interactions with co-activators. Directed mutations that alter the ligand binding pocket disrupt SF-1/co-activator interactions and reduce SF-1 transcriptional activity. Also disclosed is a method to screen chemical libraries for compounds with high specificity or binding affinity for SF-1, thereby permitting the discovery of agonist or antagonist drugs useful in treating dyslipidemias and/or in promoting cholesterol homeostasis.

Abstract: A proton conductor, a method for manufacturing the same, and an electrochemical device using the proton conductor are provided. The proton conductor includes a carbon derivative which has a carbon material selected from the group consisting of a fullerene molecule, a cluster consisting essentially of carbon, a fiber-shaped carbon anPlease do not hesitate to contact us with any questions d a tube-regarding this matter shaped carbon, and mixtures thereof, and at least a proton dissociative group, the proton dissociative group being bonded to the carbon material via a cyclic structure of tricyclic or more. The method includes the steps of obtaining the carbon derivative, hydrolyzing the derivative with alkali hydroxide, subjecting the hydrolyzed product to ion exchange, and forming a group with proton-dissociating properties.

Abstract: A power inverter control adjusts input power to track with output power to reduce energy handling requirements for an inverter DC bus. Input power to the power inverter circuit is measured and compared with a measurement of inverter output power. The comparison result is applied to a power factor correction circuit to adjust input power to track with output power, while obtaining a good power factor for the power inverter circuit. The energy requirements and ripple voltages or ripple currents on the DC bus are reduced, leading to a reduction in rating specifications for passive energy storage elements on the DC bus.

Abstract: A data writing method for RAID performs at a write cycle including a first clock and a second clock, and cooperates with a first disk, a second disk, a third disk, and a memory module. The disks store a first checking data, a second data, and a second checking data. The memory module stores the second data including a third segmented data and a fourth segmented data and the first checking data stores. First step of the method is during the first clock, writing the fourth segmented data into the second disk, reading the third segmented data from the first disk, and writing the first checking data into the third disk. Then, during the second clock, the second checking data are calculated according to the third segmented data and the fourth segmented data of the second data, and the second checking data are stored in the memory module.

Abstract: A command processing method for an RAID is performed when a usable memory of a system is smaller than a size of a command. The command processing method for the RAID includes the following steps of: dividing the command into a plurality of segmented commands, transmitting the segmented commands to the usable memory in order, and performing the segmented commands by a controller in order.

Abstract: A surface contact card latching assembly (100) is formed in a portable electronic device. The latching assembly includes a receiving portion (11) and a latch module (12). The receiving portion is configured for receiving the surface contact card, and a first end of the receiving portion forms an entrance (112) via which the surface contact card can enter or exit. The latch module includes a blocking tab (120) and an elastic latch (122). The blocking tab extends from the receiving portion for partially covering the receiving portion. The elastic latch is disposed at the first end of the receiving portion.

Abstract: A circuit for providing power factor correction includes a boost converter circuit with a boost inductance and a power factor correction switch and a control circuit. The control circuit provides a pulse width modulated signal to control the on time of a PFC switch, and also includes a power factor correction pulse width modulated device receiving as inputs a rectified AC input voltage, a DC bus voltage, a signal proportional to the current through the inductor and a reference current signal. The power factor correction pulse width modulated device also includes a pulse width modulated generator operable to provide the pulse width modulated signal to control the on time of the PFC circuit and a pulse width modulated blanking device operable to provide an enable/disable signal to disable the pulse width modulated generator when predetermined conditions are met.

Abstract: Compounds having a structure according to formula (I) where RA, RB, RC, RD, RE, and RF are as defined herein, are useful as prokinetic agents.

Abstract: A circuit for providing power factor correction in accordance with an embodiment of the present application may include a boost converter circuit and a control circuit receiving as inputs a rectified AC input voltage from a rectifier, a signal proportional to current through the boost inductor and the DC bus voltage across the capacitor of the boost converter. The control circuit provides a pulse width modulated signal to control the on time of a PFC switch. The control circuit further includes a voltage regulator and a current regulator.

Abstract: A system and process for creating custom fit artificial fingernails using a non-contact measuring device is disclosed. A fingernail is measured for its topographical configuration by an optical non-contact measuring device. The measured topography of the fingernail is then used to direct a machining device to create an artificial fingernail. Also disclosed is a method to digitally design an artificial fingernail, which has a portion of its under surface fitted to the natural fingernail by using a special computer program. The three-dimensional shape information of the digitally designed artificial fingernail is then converted into machine codes to drive a computer numerical controllable device, which will then cut the artificial fingernail from a piece of raw material. Finally, the user selected nail art can be printed onto the artificial fingernail by using a nail art printing device.

Abstract: The present utility model discloses a press fitting, comprising a pipe connector, a nipple, a check ring, a sealing ring, a pressure sleeve, etc. Said check ring is sleeved into the end groove at the end section of said nipple of said pipe connector. Said sealing ring is fit to the sealing groove of said nipple. The pressure sleeve is locked within said check ring, which has an inlet groove, a positioning annular groove connected with said inlet groove, and said positioning annular groove has larger internal diameter than that of said inlet groove. Said pressure sleeve has an extension section on its end, and the dimension of the external diameter of the larger-diameter end of said extension section is between the dimension of the internal diameter of said inlet groove (124) of said check ring (12) and that of the internal diameter of said positioning annular groove (123) of said check ring (12).

Abstract: An ionic conductor insoluble to water and fuel, and capable of stably allowing ions such as protons to conduct therethrough, a method of manufacturing the same, and an electrochemical device. The ionic conductor having a derivative in which an ion-dissociative group is bound to a carbonaceous substance composed of at least one species selected from the group consisting of fullerene molecule, cluster mainly composed of carbon, and structure of linear or tubular carbon; and a polymer of a substance having a basic group. A method of manufacturing an ionic conductor having a step of dissolving the above-described derivative; and a polymer of the substance having the basic group; into a solvent to thereby prepare a homogeneous solution; and a step of removing the solvent. An electrochemical device having a negative electrode, a positive electrode, and an ionic conductor held therebetween, wherein the ionic conductor is composed of the ionic conductor of the present invention described in the above.

Abstract: Decomposition of methane to produce carbon monoxide-free hydrogen is accomplished using un-supported, nanometer sized, hydrogen reduced, nickel oxide particles made by a precipitation process. A nickel compound, such as NiCl2 or Ni(NO3) is dissolved in water and suitably precipitated as nickel hydroxide. The precipitate is separated, dried and calcined to form the NiO catalyst precursor particles.

Abstract: Methods for assessing potential pharmacological effects and/or side effects of an agent, based on the effect of the agent on the distribution and properties of accessible regions in cellular chromatin, are provided.

Abstract: A gate driver for a power switch, comprising a gate drive circuit coupled to the gate of the power switch for at least one of turning on and turning off the power switch; a gate voltage control circuit in the gate drive circuit for controlling a voltage applied to the gate of the power switch during at least one of turning on and turning off the power switch; and a signal supplied to the gate voltage control circuit indicative of a voltage rate of change per unit time to be applied in at least one of turning on and turning off the power switch.