Abstract: An absorbent composite having a reticulated core and a fibrous stratum is disclosed. The core and stratum are integrally formed, and the stratum is coextensive with a surface of the core. In one embodiment, the composite includes strata on opposing surfaces of the core. The core includes a fibrous matrix and absorbent material. The fibrous matrix defines voids and passages between the voids, which are distributed throughout the composite. Absorbent material is located within some of the voids. On wetting, absorbent material located in these voids is expandable into the void. Methods for forming the composite and absorbent articles that include the composite are also disclosed.

Abstract: An absorbent fibrous foam composite comprising a fluid intake capacity of at least 15 g/g, a vertical wicking distance of at least 10 cm, and an absorbency under zero load of at least 15 g/g. The absorbent fibrous foam composite comprising a water insoluble fibrous material and a superabsorbent material. The absorbent fibrous foam composite made by forming a slurry of water, a water-insoluble fiber, and a binding agent. A water-swellable, water-insoluble superabsorbent material is added to the slurry and the temperature is lowered until the water freezes. The frozen water is then removed by sublimation process and an absorbent fibrous foam recovered. The Gelation Time, which represents a fluid absorption rate of superabsorbent during the preparation, is critical to preparing uniform absorbent freeze-dried foams and can be adjusted by various mixing conditions and physical and chemical superabsorbent treatments.

Abstract: Methods and compositions for the identification, isolation and characterization of regulatory DNA sequences in a cell of interest are provided. Also provided are libraries of regulatory sequences obtained according to the methods, and databases comprising collections of regulatory sequences for a particular cell of interest. In addition, various uses for the regulatory sequences so obtained, and uses for the databases of regulatory sequences, are provided. Also disclosed are computer systems and computer program products for utilizing the databases to conduct various genetic analyses, and uses of accessible regulatory sequences in the design of vectors bearing transgenes.

Abstract: An apparatus and process for forming an absorbent web (26) includes an airlaying of a first fibrous stratum (28), and an airlaying of an intermediate fibrous stratum (40) onto the first fibrous stratum. A liquid, wet-strength agent is distributed onto fibers of the intermediate fibrous stratum, and at least a second fibrous stratum (28) is airlaid onto the intermediate fibrous stratum (40). The method is desirably configured to operatively form or join the intermediate fibrous stratum (40) with the first and second fibrous strata, and render the intermediate fibrous stratum (40) substantially non-dispersible in an aqueous liquid. In a particular aspect, the strata of the web (26) can be operatively compressed prior to curing the wet-strength agent. In another aspect, the liquid wet-strength agent can be distributed onto the fibers of the intermediate fibrous stratum (40) during an airlaying of the intermediate fibrous stratum.

Abstract: An apparatus and process for forming an absorbent web (26) includes an airlaying of a first fibrous stratum (28) which has a first quantity of absorbent fibers; an airlaying of a second fibrous stratum (34) which has a second quantity of absorbent fibers; and an airlaying of a third, intermediate fibrous stratum (40) which has a third quantity of absorbent fibers. The intermediate fibrous stratum has a location that is interposed between the first fibrous stratum and the second fibrous stratum. A liquid, wet-strength agent is distributed onto the fibers of the intermediate fibrous stratum (40) during the airlaying of the intermediate fibrous stratum to thereby render the intermediate fibrous stratum substantially non-dispersible.

Abstract: A floating frame for an optical disc loader. It includes a pivoting-type sub-chassis of 1-degree of freedom of movement. It is rigidly connected to a chassis without any floaters. Floaters are placed at the four comers of the chassis to support the entire loader. The floater has a wide mid-section and a narrow tip. Above the mid-section are upper slots, and below the mid-section are lower slots. The floater should preferably be made of flexible material such as rubber.

Abstract: The invention is directed to a method of making carboxylated cellulose fibers whose fiber strength and degree of polymerization is not significantly sacrificed. The method involves the use of cyclic nitroxide free radical compounds as a primary oxidant and a hypohalite salt as a secondary oxidant in an aqueous environment. Preferably the oxidized cellulose is then stabilized against D.P. loss in alkaline environments and color reversion with a reducing agent such as sodium borohydride. Alternatively it may be treated with an oxidant such as sodium chlorite. The method results in a high percentage of carboxyl groups located at the fiber surface. The product is especially useful as a papermaking fiber where it contributes strength and has a higher attraction for cationic additives. The product is also useful as an additive to recycled fiber to increase strength. The method can be used to improve properties of either virgin or recycled fiber.

Abstract: Methods for the design of exogenous regulatory molecules, comprising a DNA-binding domain and a functional domain, are provided. The methods rely on the identification, isolation and characterization of regulatory DNA sequences obtained on the basis of their accessibility in cellular chromatin.

Abstract: A composite absorbent structure and method are disclosed including providing a first wicking layer having preferred liquid transport properties in a preferred contact with a second absorbent retention layer. The composite absorbent structure of the present invention provides preferred liquid transport and liquid retention properties. The composite absorbent structure has a first wicking layer in a preferred contact with the second retention layer by a novel intimate contact means effective to achieve a Contact Intimacy Ratio providing the preferred liquid transport and liquid retention functions when the first wicking layer and the second absorbent retention layer are combined together in accordance with the present invention.

Abstract: An absorbent composite material composed of a fibrous absorbent material and a binding agent, the binding agent binding at least a portion of the fibers of the fibrous absorbent material. The fibrous absorbent material is preferably selected from the group consisting of fluff pulp, synthetic fibers, natural fibers, and combinations thereof. The material suitable for use as an absorbent in personal care absorbent articles such as diapers, training pants, and adult incontinence garments.

Abstract: A nonwoven web and method of preparing a novel nonwoven web of synthetic fiber are disclosed. An aqueous solution amide crosslinked synthetic precursor polymer is extruded under defined conditions through a plurality of die orifices to form a plurality of threadlines. The threadlines are attenuated with a defined primary gaseous source to form fiber under conditions of controlled macro scale turbulence and under conditions sufficient to permit the viscosity of each threadline, as it leaves a die orifice and for a distance of no more than about 8 cm, to increase incrementally with increasing distance from the die, while substantially maintaining uniformity of viscosity in the radial direction, at a rate sufficient to provide fiber having the desired attenuation and mean fiber diameter without significant fiber breakage. The attenuated threadlines are dried with a defined secondary gaseous source. The resulting fibers are deposited randomly on a moving foraminous surface to form a substantially uniform web.

Abstract: A nonwoven web and method of preparing a novel nonwoven web of synthetic fiber are disclosed. An aqueous solution amide crosslinked synthetic precursor polymer is extruded under defined conditions through a plurality of die orifices to form a plurality of threadlines. The threadlines are attenuated with a defined primary gaseous source to form fiber under conditions of controlled macro scale turbulence and under conditions sufficient to permit the viscosity of each threadline, as it leaves a die orifice and for a distance of no more than about 8 cm, to increase incrementally with increasing distance from the die, while substantially maintaining uniformity of viscosity in the radial direction, at a rate sufficient to provide fiber having the desired attenuation and mean fiber diameter without significant fiber breakage. The attenuated threadlines are dried with a defined secondary gaseous source. The resulting fibers are deposited randomly on a moving foraminous surface to form a substantially uniform web.

Abstract: A nonwoven web and method of preparing a novel nonwoven web of synthetic fiber are disclosed. An aqueous solution amide crosslinked synthetic precursor polymer is extruded under defined conditions through a plurality of die orifices to form a plurality of threadlines. The threadlines are attenuated with a defined primary gaseous source to form fiber under conditions of controlled macro scale turbulence and under conditions sufficient to permit the viscosity of each threadline, as it leaves a die orifice and for a distance of no more than about 8 cm, to increase incrementally with increasing distance from the die, while substantially maintaining uniformity of viscosity in the radial direction, at a rate sufficient to provide fiber having,the desired attenuation and mean fiber diameter without significant fiber breakage. The attenuated threadlines are dried with a defined secondary gaseous source. The resulting fibers are deposited randomly on a moving foraminous surface to form a substantially uniform web.

Abstract: A nonwoven web and method of preparing a novel nonwoven web of synthetic fiber are disclosed. An aqueous solution amide crosslinked synthetic precursor polymer is extruded under defined conditions through a plurality of die orifices to form a plurality of threadlines. The threadlines are attenuated with a defined primary gaseous source to form fiber under conditions of controlled macro scale turbulence and under conditions sufficient to permit the viscosity of each threadline, as it leaves a die orifice and for a distance of no more than about 8 cm, to increase incrementally with increasing distance from the die, while substantially maintaining uniformity of viscosity in the radial direction, at a rate sufficient to provide fiber having the desired attenuation and mean fiber diameter without significant fiber breakage. The attenuated threadlines are dried with a defined secondary gaseous source. The resulting fibers are deposited randomly on a moving foraminous surface to form a substantially uniform web.

Abstract: There is provided an absorbent system for personal care products which may be transversely divided into about an equally sized center zone, two intermediate zones and two end zones where the ratio of the amount of liquid stored in the center zone to the amount of liquid stored in at least one of the end zones 30 minutes each of three insults of 80 ml according to a MIST Evaluation Test after less than 5:1. Such an absorbent system may be used in personal care products like diapers, training pants, feminine hygiene products, absorbent underpants, adult incontinence products, and the like.

Abstract: A grinding machine includes a work table for supporting a work piece to be ground, a grinding member movable relative to the work piece, and a load cell attached to the grinding member for detecting an engagement of the grinding member onto the work piece or for detecting a reactive force of the work piece against the grinding member. The load cell may send out a signal in order to stop or to move the grinding member relative to the work piece in order to suitably working or grinding the work piece when the grinding member is engaged onto the work piece with an overload.

Abstract: Methods for the identification of a drug target, wherein the drug target is a component of a signal transduction pathway, are provided. The methods are based, in part, on selection of a gene of therapeutic interest and determination of regulatory DNA sequences which regulate expression of the gene in a cell of interest, followed by reconstruction of signal transduction pathways which act on molecules which bind to the regulatory sequence. Also provided are methods for assessing potential pharmacological effects and/or side effects of an agent, based on the effect of the agent on the distribution and properties of accessible regions in cellular chromatin.

Abstract: The present invention provides novel sixteen-membered macrolide compounds that are useful as anti-infective agents or as intermediates thereto. The present invention also provides methods for the preparation of these compounds, and methods and formulations for their use. In one aspect of the present invention, sixteen-membered macrolide possessing a side chain Z are provided where Z is aliphatic, aryl, alkylaryl, halide, ═NOR3, ═NNHR3, or —W—R3 where W is O, S, NC(═O)R4, NC(═O)OR4, NC(═O)NHR4 or NR4 where R3 and R4 are each independently hydrogen, aliphatic, aryl or alkylaryl. In another aspect of the present invention, bicyclic compounds are provided where one of the cyclic-components is a sixteen-membered macrolide and the other is a cyclic moiety whose cyclic structure is formed by between 3 and 10 atoms. In another aspect of the present invention, sixteen-membered macrolide compounds that bind to the domain II region of the 23S RNA are provided.

Abstract: A distinctive absorbent article includes an absorbent core having multiple absorbent layers, wherein the absorbent layers interact in such a manner which preferentially locates absorbed liquid in an appointed, high saturation wicking layer. The localization of the liquid within this wicking layer increases the potential of this layer to move liquid through capillary action due to the higher saturation level and increased amount of liquid available. The intake capability of the absorbent system is maintained or improved over current systems by keeping a second layer of the absorbent system at low saturation levels through as many insults of the product as possible, while providing optimum intake performance through appropriate control of the composite properties.

Abstract: Methods and compositions for the identification, isolation and characterization of regulatory DNA sequences in a cell of interest are provided. Also provided are libraries of regulatory sequences obtained according to the methods, and databases comprising collections of regulatory sequences for a particular cell of interest. In addition, various uses for the regulatory sequences so obtained, and uses for the databases of regulatory sequences, are provided. Also disclosed are computer systems and computer program products for utilizing the databases to conduct various genetic analyses, and uses of accessible regulatory sequences in the design of vectors bearing transgenes.