Patents by Inventor Yong Xu

Yong Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100179167
    Abstract: A method for treating a subject having an inflammatory or auto-immune disease with a substituted isoxazolo pyridinone. Also, a method for administering a substituted isoxazolo pyridinone to a cell to retain or increase glucocorticoid receptor transrepression activity with only minimal glucocorticoid receptor transactivation activity.
    Type: Application
    Filed: January 13, 2010
    Publication date: July 15, 2010
    Inventors: Huaqiang Eric Xu, Yong Xu, Yuanzheng He
  • Patent number: 7750007
    Abstract: The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II): or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer and other Pim kinase-associated conditions are also disclosed.
    Type: Grant
    Filed: November 6, 2007
    Date of Patent: July 6, 2010
    Assignee: SuperGen, Inc.
    Inventors: David J. Bearss, Xiao-Hui Liu, Hariprasad Vankayalapati, Yong Xu
  • Patent number: 7713904
    Abstract: This invention relates to a composition with desulfurization property, in which the desulfurization component is a kind of molecular sieves with incorporation of vanadium into the skeleton. The composition has high hydrothermal stability and the vanadium is hard to lose.
    Type: Grant
    Filed: June 24, 2004
    Date of Patent: May 11, 2010
    Assignees: China Petroleum & Chemical Corporation, Research Institute of Petroleum Processing, SINOPEC
    Inventors: Baoning Zong, Jinyu Zheng, Wenhua Xie, Yong Xu, Xuhong Mu, Yibin Luo, Minggang Li, Xingtian Shu
  • Publication number: 20100037682
    Abstract: A microcantilever sensor includes a supporting substrate, a cantilever spring element at least partially disposed over the support substrate, a probe layer disposed over the first side of the cantilever spring element, and a piezoresistive transducer attached to the second side of the cantilever spring element. The cantilever spring element is characterized by having a first side and a second side and comprising a polymer having a Young's modulus less than about 100 Gpa. Sensing systems that incorporate the cantilever sensor of the invention include a detector in communication with the piezoresistive transducer to provide measurements of surface strain changes in the piezoresistive transducer.
    Type: Application
    Filed: January 20, 2006
    Publication date: February 18, 2010
    Applicant: WAYNE STATE UNIVERSITY
    Inventor: Yong Xu
  • Publication number: 20090298900
    Abstract: Compounds represented by Formula I and II, or pharmaceutically acceptable salts thereof: inhibit bacterial 2-epimerase and are useful anti-infective agents.
    Type: Application
    Filed: May 11, 2009
    Publication date: December 3, 2009
    Inventors: David J. Bearss, Hariprasad Vankayalapati, Yong Xu, Charles Erec Stabbins, Vincent A. Fischetti
  • Publication number: 20090296706
    Abstract: A method, a system, and a processor for processing a network address translation (NAT) service are provided. The method includes: performing NAT service identification of a received message, and selecting a corresponding NAT service processor for processing a NAT service of a message that needs a NAT service processing from at least two NAT service processors. Through embodiments of the disclosure, a demand for the system to process a lot of NAT services within a short time is fulfilled, so as to increase the capacity of processing NAT services of the system.
    Type: Application
    Filed: May 20, 2009
    Publication date: December 3, 2009
    Applicant: CHENGDU HUAWEI SYMANTEC TECHNOLOGIES CO., LTD.
    Inventors: Rihua Zhang, Zhiqiang Zhu, Guibin Hou, Xiangdong Meng, Shifeng Mao, Rong He, Wenhui Xie, Yuzhu Chen, Ran Su, Yong Xu, Zhijun Cheng
  • Publication number: 20090285772
    Abstract: Quinoline derivatives, particularly 4-anilinoquinoline derivatives, are provided. Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders.
    Type: Application
    Filed: April 10, 2009
    Publication date: November 19, 2009
    Applicant: SuperGen, Inc.
    Inventors: Pasit Phiasivongsa, Sanjeev G. Redkar, Swarna Gamage, Darby Brooke, William Denny, David J. Bearss, Hariprasad Vankayalapati, Yong Xu, Krzysztof Swierczek
  • Publication number: 20090280528
    Abstract: Recombinant DNA encoding NruI- and SboI-like restriction endonucleases and methylases and their amino acid sequences are provided as well as methods for expressing the enzymes in transformed host cells and purifying the enzymes.
    Type: Application
    Filed: March 30, 2007
    Publication date: November 12, 2009
    Applicant: NEW ENGLAND BIOLABS, INC.
    Inventors: Zhenyu Zhu, Jack S. Benner, II, Shuang-Yong Xu
  • Patent number: 7617080
    Abstract: Data from a target system (616) that exhibits a non-linear relationship between system properties and measurement data, is processed by applying a linear filter (F) to improve resolution and accuracy. The filter reduces inaccuracies that are introduced by an algorithm used to reconstruct the data. The filter is defined by assigning time varying functions, such as sinusoids (200), to elements (210) in a model (Y) of the system to perturbate the elements. The resulting data output from the model is reconstructed using the same algorithm used to subsequently reconstruct the data from the target system. The filter is defined as a matrix (F) that transforms the reconstructed data of the model (X) back toward the known properties of the model (Y). A library of filters can be pre-calculated for different applications. In an example implementation, the system is tissue that is imaged using optical tomography.
    Type: Grant
    Filed: July 19, 2004
    Date of Patent: November 10, 2009
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Randall L. Barbour, Harry L. Graber, Yaling Pei, Yong Xu
  • Patent number: 7607415
    Abstract: An engine system that compensates for disturbances in a crankshaft signal is provided. The system includes: an error module that computes an error between an ideal period and an actual period of a crankshaft signal; a correction factor module that determines a correction factor based on the error; and a compensation module that applies the correction factor to the actual period of the crankshaft signal.
    Type: Grant
    Filed: October 3, 2006
    Date of Patent: October 27, 2009
    Assignee: GM Global Technology Operations, Inc.
    Inventors: David S. Mathews, Tameem K. Assaf, Ronald J. Kubani, David L. St. Pierre, Yong Xu
  • Patent number: 7591170
    Abstract: A rough road detection system includes an engine speed module, a feature space module, a normalization module, and a rough road module. The engine speed module generates an engine speed signal based on a crank signal. The feature space module generates a feature space signal based on the engine speed signal. The normalization module generates a normalized signal. The normalized signal is based on the feature space signal and a normalization value that varies in accordance with the engine speed signal. The rough road module determines whether a rough road condition exists based on the normalized signal.
    Type: Grant
    Filed: January 23, 2007
    Date of Patent: September 22, 2009
    Assignee: GM Global Technology Operations, Inc.
    Inventors: Jian Lin, Yong Xu, Wenbo Wang, Michael R. Grimes
  • Patent number: 7575373
    Abstract: A cassette tray includes a front clamp, a rear clamp, and opposing side clamps. A front clamp supporting unit supports the front clamp such that the front clamp may be moved in a direction vertical to a surface of the X-ray film cassette. A rear clamp supporting unit supports the rear clamp such that the rear clamp may be moved in a direction parallel to the surface of the X-ray film cassette. A side clamp supporting unit supports the side clamps such that the side clamps may be moved in a direction in which the side clamps are apart from each other and in a direction in which the side clamps are close to each other, wherein the side clamps are driven by a driving unit according to the advance and retreat of the rear clamp.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: August 18, 2009
    Assignee: GE Medical Systems Global Technology Company, LLC
    Inventors: Jiake Xu, Yong Xu
  • Publication number: 20090039821
    Abstract: A step motor driving apparatus includes a micro control unit (MCU), a pulse generator, a first step motor driver, a second step motor driver, and a communication port. The first step motor driver is configured for driving a first step motor and connected to the MCU. The second step motor driver is configured for driving a second step motor and connected to the MCU. The MCU is connected to the second step motor driver via the pulse generator. The pulse generator is configured to supply pulse signals to the second step motor driver. The communication port is connected to the MCU. The MCU receives a corresponding command from an external control apparatus via the communication port. The MCU selectively controls the first step motor driver to drive the first step motor or controls the second step motor driver to drive the second step motor according to the command.
    Type: Application
    Filed: December 3, 2007
    Publication date: February 12, 2009
    Applicants: HONG FU JIN PRECISION INDUSTRY (Shenzhen)CO., LTD., HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: TENG-TSUNG HUANG, GUO-JUN YU, HUA-YONG XU, DE-HUA CAO
  • Publication number: 20090029418
    Abstract: The present invention relates to compositions including: (1) isolated DNA encoding the Stul restriction endonuclease and isolated DNA encoding cognate and non-cognate methylase; (2) vectors and cells containing the isolated DNA; and (3) methods for producing the Stul restriction endonuclease.
    Type: Application
    Filed: February 27, 2007
    Publication date: January 29, 2009
    Applicant: NEW ENGLAND BIOLABS, INC.
    Inventors: Zhenyu Zhu, Shuang-Yong Xu
  • Publication number: 20090029376
    Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions include restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.
    Type: Application
    Filed: July 14, 2008
    Publication date: January 29, 2009
    Applicant: New England Biolabs, Inc.
    Inventors: Zhenyu Zhu, Aine Blanchard, Shuang-Yong Xu, Shengxi Guan, Hua Wei, Penghua Zhang, Dapeng Sun, Siu-Hong Chan
  • Publication number: 20080293733
    Abstract: Axl kinase inhibitory compounds are disclosed, as well as compositions and methods of using the same in the treatment of cancer and other conditions mediated by and/or associated with Axl kinase.
    Type: Application
    Filed: April 11, 2008
    Publication date: November 27, 2008
    Applicant: SUPERGEN, INC.
    Inventors: David J. Bearss, Hariprasad Vankayalapati, Yong Xu
  • Publication number: 20080268507
    Abstract: Recombinant nicking endonucleases and associated methylases have been obtained and sequenced and their specificity has been defined. A mutant form of the nicking endonuclease has been cloned where the mutation includes deletion of amino acid sequences at the C-terminal end of the protein. The nicking enzymes have been used for a number of purposes including: amplifying DNA from as few cells as can be found in a single bacterial colony in the presence of a strand displacing polymerase; and for removing genomic DNA in a biological preparation where it is deemed to be a contaminant.
    Type: Application
    Filed: October 21, 2005
    Publication date: October 30, 2008
    Applicant: AIRBUS DEUTSCHLAND GMBH
    Inventors: Shuang-yong Xu, Zhenyu Zhu, Shi-hong Chan, Yan Xu
  • Publication number: 20080261988
    Abstract: The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II): or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer and other Pim kinase-associated conditions are also disclosed.
    Type: Application
    Filed: November 6, 2007
    Publication date: October 23, 2008
    Applicant: SUPERGEN, INC.
    Inventors: David J. Bearss, Xiao-Hui Liu, Hariprasad Vankayalapati, Yong Xu
  • Publication number: 20080213860
    Abstract: A nicking endonuclease is described which has an amino acid sequence with at least 70% identity to SEQ ID NO:6 and comprising a mutation at least one of an arginine or gutamic acid corresponding to position 507 and position 546 respectively in SEQ ID NO:6.
    Type: Application
    Filed: July 22, 2005
    Publication date: September 4, 2008
    Applicant: NEW ENGLAND BIOLABS, INC.
    Inventors: Shuang-Yong Xu, Zhenyu Zhu, Timothy Meixsell
  • Publication number: 20080187928
    Abstract: Disclosed herein are methods for enhancing one or more effects of exercise in a subject by administering a PPAR? agonist (e.g., GW1516) to the subject in combination with an exercise program. Also disclosed are gene expression profiles unique to the combination of agonist-induced PPAR? activation and exercise. Such profiles are useful, at least, in methods for identifying the use of performance-enhancing drugs in exercised subjects (such as, professional or athletes). Direct interactions between PPAR? and exercised-induced kinases (e.g., AMPK or its subunits, AMPK ?1 and/or AMPK ?2) also are disclosed. Such protein-protein interactions provide new targets for identification of useful compounds.
    Type: Application
    Filed: December 28, 2007
    Publication date: August 7, 2008
    Inventors: Ronald M. Evans, Vihang A. Narkar, Yong-Xu Wang, Michael Downes, Ruth T. Yu