Patents by Inventor Yong Xu

Yong Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140154780
    Abstract: Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer.
    Type: Application
    Filed: December 20, 2013
    Publication date: June 5, 2014
    Applicant: NEW ENGLAND BIOLABS, INC.
    Inventors: Zhenyu Zhu, Aine Quimby, Shengxi Guan, Dapeng Sun, Yishu Huang, Xuhui Lai, Siu-hong Chan, Xianghui Li, Shuang-Yong Xu, Chunhua Zhang
  • Publication number: 20140154779
    Abstract: Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer.
    Type: Application
    Filed: December 20, 2013
    Publication date: June 5, 2014
    Applicant: NEW ENGLAND BIOLABS, INC.
    Inventors: Zhenyu Zhu, Aine Quimby, Shengxi Guan, Dapeng Sun, Yishu Huang, Xuhui Lai, Siu-hong Chan, Xianghui Li, Shuang-Yong Xu, Chunhua Zhang
  • Publication number: 20140154676
    Abstract: Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer.
    Type: Application
    Filed: December 20, 2013
    Publication date: June 5, 2014
    Applicant: NEW ENGLAND BIOLABS, INC.
    Inventors: Zhenyu Zhu, Aine Quimby, Shengxi Guan, Dapeng Sun, Yishu Huang, Xuhui Lai, Siu-hong Chan, Xianghui Li, Shuang-Yong Xu, Chunhua Zhang
  • Patent number: 8737388
    Abstract: A system for processing packets in a distributed architecture system includes a main control board, at least one service board, and at least one interface board. The system determines a specified CPU corresponding to a received packet; and, by the service board corresponding to the CPU, processes the received packet. The received packets are processed in the service board corresponding to the specified CPU. Therefore, the packets are evenly distributed to all service boards for being processed, the workload of the main control board is relieved, the service throughput is increased significantly, and the packet processing efficiency of the whole architecture is improved.
    Type: Grant
    Filed: July 5, 2013
    Date of Patent: May 27, 2014
    Assignee: Huawei Technologies Co., Ltd.
    Inventors: Zhiqiang Zhu, Rihua Zhang, Guibin Hou, Yong Xu, Wenhui Xie, Bo Ma, Guolu Gao, Xiaoping Lu, Cuihua Fu
  • Patent number: 8710057
    Abstract: The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II): or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer and other Pim kinase-associated conditions are also disclosed.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: April 29, 2014
    Assignee: Tolero Pharmaceuticals, Inc.
    Inventors: David J. Bearss, Xiao-Hui Liu, Hariprasad Vankayalapati, Yong Xu
  • Patent number: 8689701
    Abstract: A wheel truck, including: a front wheel pair assembly and a rear wheel pair assembly, two side frame assemblies, two spring suspension devices, and a bolster assembly. The spring suspension devices include a bearing spring unit, a damping spring, and a wedge. The wedge includes a primary friction surface and a secondary friction surface. The primary friction surface is attached to a column surface of the side frame assembly. The secondary friction surface is attached to an inclined surface of the bolster assembly. The wedge has the following structure parameters: ?=16-30°, and ?<tg?<?+?1, in which a represents an included angle between the secondary friction surface and a vertical plane, ? represents a friction coefficient of the primary friction surface, and ?1 represents a friction coefficient of the secondary friction surface.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: April 8, 2014
    Assignee: CSR Yangtze Co., Ltd.
    Inventors: Mingdao Sun, Yong Xu, Baolei Wang, Yongjiang Li
  • Patent number: 8691549
    Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.
    Type: Grant
    Filed: January 8, 2013
    Date of Patent: April 8, 2014
    Assignee: New England Biolabs, Inc.
    Inventors: Zhenyu Zhu, Aine Quimby, Shuang-Yong Xu, Shengxi Guan, Hua Wei, Penghua Zhang, Dapeng Sun, Siu-hong Chan
  • Patent number: 8683927
    Abstract: A wheel truck for a railroad car, including: a front wheel pair assembly and a rear wheel pair assembly; two side frame assemblies, each side frame assembly including a square box and journal-box guides; two spring suspension devices; and a bolster assembly including two ends disposed on the two spring suspension devices, respectively. The bolster assembly includes a pilot hole in the center and two mounting holes on the two ends, the pilot hole is rotationally matched with a cylindrical upper center plate of a car body for transmitting vertical and horizontal forces from the car body, and the two mounting holes are disposed above the two spring suspension devices, respectively. Each mounting hole receives a lower side bearing, and the lower side bearing is matched with a corresponding upper side bearing disposed on each side of the car body for transmitting the vertical load from the car body.
    Type: Grant
    Filed: October 30, 2012
    Date of Patent: April 1, 2014
    Assignee: CSR Yangtze Co., Ltd.
    Inventors: Mingdao Sun, Yong Xu, Baolei Wang, Yongjiang Li, Hui Luo, Wanlu Gong, Guangyi Xiao
  • Publication number: 20140079750
    Abstract: Oral care compositions suitable for whitening and remineralizing teeth are described. The oral care compositions comprise a phosphate source and regeneration-source calcium salt having a particle size of five (5) microns or less so that in-situ hydroxyapatite may be generated upon use.
    Type: Application
    Filed: March 29, 2012
    Publication date: March 20, 2014
    Inventors: Xiaoke Li, Yan Deng, Guan-Jun Ding, Yong Xu
  • Patent number: 8673610
    Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.
    Type: Grant
    Filed: January 8, 2013
    Date of Patent: March 18, 2014
    Assignee: New England Biolabs, Inc.
    Inventors: Zhenyu Zhu, Aine Quimby, Shuang-Yong Xu, Shengxi Guan, Hua Wei, Penghua Zhang, Dapeng Sun, Siu-hong Chan
  • Publication number: 20140059814
    Abstract: A connector securing a liner to a scuff in a container sidewall is disclosed. The connector is adapted to receive and secure various thicknesses of liners and scuffs. The connector is made of a light weight, high strength flexible material and well suited to secure non-metallic scuffs and non-metallic linings. The connector includes a transition piece that utilizes clamping force (pre-tightening force) to connect two different thicknesses of panels made of continuous glass fiber reinforced thermoplastic material. The connector includes a thick lower opening adapted to secure the scuff and a thin upper opening adapted to secure the liner. In an exemplary embodiment of the invention, the width of the lower opening is between 5.0 mm and 5.5 mm while the width of the upper opening is between 1.5 mm and 2.0 mm.
    Type: Application
    Filed: August 30, 2012
    Publication date: March 6, 2014
    Inventors: Mark Roush, Ren Yong Xu
  • Patent number: 8657363
    Abstract: A connector securing a liner to a scuff in a container sidewall is disclosed. The connector is adapted to receive and secure various thicknesses of liners and scuffs. The connector is made of a light weight, high strength flexible material and well suited to secure non-metallic scuffs and non-metallic linings. The connector includes a transition piece that utilizes clamping force (pre-tightening force) to connect two different thicknesses of panels made of continuous glass fiber reinforced thermoplastic material. The connector includes a thick lower opening adapted to secure the scuff and a thin upper opening adapted to secure the liner. In an exemplary embodiment of the invention, the width of the lower opening is between 5.0 mm and 5.5 mm while the width of the upper opening is between 1.5 mm and 2.0 mm.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: February 25, 2014
    Assignee: Vanguard National Trailer Corporation
    Inventors: Mark Roush, Ren Yong Xu
  • Patent number: 8636416
    Abstract: A lower side bearing for a wheel truck, including: a first friction board, a second friction board, an inner pedestal, a bearing sleeve sleeving the inner pedestal, a pressure block, a pressure plate, and an elastic component. The pressure block is disposed on an upper part of the inner pedestal, and the second friction board is disposed on a top of the pressure block. The pressure plate is disposed on an upper part of the bearing sleeve, and the first friction board is disposed on a top of the pressure plate. A friction coefficient ?k of the first friction board and a friction coefficient ?z of the second friction board meet the relation: ?k>?z. The elastic component is disposed between the inner pedestal and the bearing sleeve for controlling a relative position of the inner pedestal and the bearing sleeve.
    Type: Grant
    Filed: October 30, 2012
    Date of Patent: January 28, 2014
    Assignee: CSR Yangtze Co., Ltd.
    Inventors: Mingdao Sun, Yong Xu, Baolei Wang, Wanlu Gong
  • Patent number: 8637291
    Abstract: Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer.
    Type: Grant
    Filed: February 7, 2011
    Date of Patent: January 28, 2014
    Assignee: New England Biolabs, Inc.
    Inventors: Zhenyu Zhu, Aine Quimby, Shengxi Guan, Dapeng Sun, Yishu Huang, Xuhui Lai, Siu-hong Chan, Xianghui Li, Shuang-Yong Xu, Chunhua Zhang
  • Patent number: 8628945
    Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.
    Type: Grant
    Filed: January 8, 2013
    Date of Patent: January 14, 2014
    Assignee: New England Biolabs, Inc.
    Inventors: Zhenyu Zhu, Aine Quimby, Shuang-Yong Xu, Shengxi Guan, Hua Wei, Penghua Zhang, Dapeng Sun, Siu-hong Chan
  • Publication number: 20140003584
    Abstract: A cross arm for X-ray equipment. The cross arm comprises a guide on the cross arm, a tube on the guide, and a linkage device, wherein the tube is configured to move along the guide when the cross arm rotates.
    Type: Application
    Filed: June 27, 2013
    Publication date: January 2, 2014
    Inventors: Zhenggang LING, Zhengjun WANG, Yicheng WANG, Yong XU
  • Publication number: 20140005238
    Abstract: Disclosed herein are methods for enhancing one or more effects of exercise in a subject by administering a PPAR? agonist (e.g., GW1516) to the subject in combination with an exercise program. Also disclosed are gene expression profiles unique to the combination of agonist-induced PPAR? activation and exercise. Such profiles are useful, at least, in methods for identifying the use of performance-enhancing drugs in exercised subjects (such as, professional or athletes). Direct interactions between PPAR? and exercised-induced kinases (e.g., AMPK or its subunits, AMPK ?1 and/or AMPK ?2) also are disclosed. Such protein-protein interactions provide new targets for identification of useful compounds.
    Type: Application
    Filed: May 21, 2013
    Publication date: January 2, 2014
    Inventors: Ronald M. Evans, Vihang A. Narkar, Yong-Xu Wang, Michael Downes, Ruth T. Yu
  • Publication number: 20130303539
    Abstract: Compounds, compositions and methods useful for treating ocular diseases are provided. In particular, antagonists of TRPV4, their synthesis, pharmaceutical compositions thereof and methods of treating ocular diseases such as glaucoma, are disclosed.
    Type: Application
    Filed: March 15, 2013
    Publication date: November 14, 2013
    Inventors: David Krizaj, Glenn D. Prestwich, Peter Barabas, Yong Xu, Daniel Ryskamp
  • Publication number: 20130297671
    Abstract: A system for processing packets in a distributed architecture system includes a main control board, at least one service board, and at least one interface board. The system determines a specified CPU corresponding to a received packet; and, by the service board corresponding to the CPU, processes the received packet. The received packets are processed in the service board corresponding to the specified CPU. Therefore, the packets are evenly distributed to all service boards for being processed, the workload of the main control board is relieved, the service throughput is increased significantly, and the packet processing efficiency of the whole architecture is improved.
    Type: Application
    Filed: July 5, 2013
    Publication date: November 7, 2013
    Inventors: Zhiqiang Zhu, Rihua Zhang, Guibin Hou, Yong Xu, Wenhui Xie, Bo Ma, Guolu Gao, Xiaoping Lu, Cuihua Fu
  • Publication number: 20130264199
    Abstract: A cylindrical magnetron sputtering target assembly includes a head and a main body connecting to the head. The main body includes a target, a protecting element located partially around the target, and an insulating assembly. The insulating assembly includes at least one insulating element. The insulating element is fastened to the inner sidewall of the inner plate.
    Type: Application
    Filed: June 19, 2012
    Publication date: October 10, 2013
    Applicants: HON HAI PRECISION INDUSTRY CO., LTD., HONG FU JIN PRECISION INDUSTRY (ShenZhen) CO., LTD.
    Inventors: TENG-TSUNG HUANG, HUA-YONG XU, ZHEN-ZHANG LIU