Abstract: According to embodiments of present disclosure, a method to produce a compound of Formula 19 is provided. Using this method, the compound of Formula 19 may be produced effectively.

Abstract: An electronic device includes a main body, an installing assembly, a support, and a connecting assembly. The main body includes a shell and a display screen installed in the shell. The installing assembly is connected to a side of the shell opposite to the display screen. The connecting assembly is rotatably connected between the installing assembly and the support. The support includes a connecting pole and two opposite extending poles perpendicularly extending out from two opposite ends of the connecting pole. The connecting pole and the extending poles cooperatively bound a receiving space. The connecting assembly can be rotated to be received in the receiving space.

Abstract: The present invention provides protein kinase having one of the following structures (I), (II) or (III): or a stereoisomer, prodrug, tautomer or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer, autoimmune, inflammatory and other Pim kinase-associated conditions are also disclosed.

Abstract: A method and an apparatus are provided. The apparatus is a hardware module that controls a power mode of a plurality of modules. The apparatus receives an indication of a desired operational frequency. Based on the received indication, the apparatus determines to switch from a first power mode associated with a first set of modules to a second power mode corresponding to the desired operational frequency and associated with a second set of modules. The apparatus enables modules in the second set of modules that are unassociated with the first power mode, stops traffic through the plurality of modules upon expiration of a time period after enabling the modules in the second set of modules that are unassociated with the first power mode, routes traffic through the second set of modules, and disables modules in the first set of modules that are unassociated with the second power mode.

Abstract: The present invention relates to the field of medical imaging. More particularly, embodiments of the invention relate to methods, systems, and devices for imaging, including for tomography-based applications. Embodiments of the invention include, for example, a computed tomography based imaging system comprising: (a) at least one wide-beam gray-scale imaging chain capable of performing a global scan of an object and acquiring projection data relating to the object; (b) at least one narrow-beam true-color imaging chain capable of performing a spectral interior scan of a region of interest (ROI) of and acquiring projection data relating to the object; (c) a processing module operably configured for: (1) receiving the projection data; (2) reconstructing the ROI into an image by analyzing the data with a color interior tomography algorithm, aided by an individualized gray-scale reconstruction of an entire field of view (FOV), including the ROI; and (d) a processor for executing the processing module.

Abstract: The present invention relates to the field of optical imaging and therapeutics. More particularly, embodiments of the present invention provide minimally-invasive Fiberoptic Microneedle Devices (FMDs) for light-based therapeutics, which physically penetrate tissue and deliver light directly into the target area below the skin surface (FIG. 1). A preferred embodiment of the invention is a fiberoptic microneedle device comprising: (a) one or more silica-based needles capable of guiding light and comprising a length of about 0.5-6 mm, a base having an outer diameter in the range of about 100-150 micron, and a tip having an outer diameter in the range of about 5-20 micron; (b) a support member to which the needles are secured; (c) a ferrule comprising one or more holes for each of the needles, wherein the ferrule is operably configured to provide mechanical support to each needle at all or some portion of the length of the needle.

Abstract: A resonant sensor is provided. The resonant sensor may have a structure including a base portion, a mass portion, and a mechanical beam connecting the base portion to the mass portion. In addition, the structure may include a first sensing beam formed from a sensing material responsive to mechanical strain where a gap is formed between the sensing beam and the mechanical beam.

Abstract: Compounds represented by Formula I and II, or pharmaceutically acceptable salts thereof: inhibit bacterial 2-epimerase and are useful anti-infective agents.

Abstract: Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer.

Abstract: Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer.

Abstract: Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer.

Abstract: Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer.

Abstract: A system for processing packets in a distributed architecture system includes a main control board, at least one service board, and at least one interface board. The system determines a specified CPU corresponding to a received packet; and, by the service board corresponding to the CPU, processes the received packet. The received packets are processed in the service board corresponding to the specified CPU. Therefore, the packets are evenly distributed to all service boards for being processed, the workload of the main control board is relieved, the service throughput is increased significantly, and the packet processing efficiency of the whole architecture is improved.

Abstract: The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II): or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer and other Pim kinase-associated conditions are also disclosed.

Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.

Abstract: A wheel truck, including: a front wheel pair assembly and a rear wheel pair assembly, two side frame assemblies, two spring suspension devices, and a bolster assembly. The spring suspension devices include a bearing spring unit, a damping spring, and a wedge. The wedge includes a primary friction surface and a secondary friction surface. The primary friction surface is attached to a column surface of the side frame assembly. The secondary friction surface is attached to an inclined surface of the bolster assembly. The wedge has the following structure parameters: ?=16-30°, and ?<tg?<?+?1, in which a represents an included angle between the secondary friction surface and a vertical plane, ? represents a friction coefficient of the primary friction surface, and ?1 represents a friction coefficient of the secondary friction surface.

Abstract: A wheel truck for a railroad car, including: a front wheel pair assembly and a rear wheel pair assembly; two side frame assemblies, each side frame assembly including a square box and journal-box guides; two spring suspension devices; and a bolster assembly including two ends disposed on the two spring suspension devices, respectively. The bolster assembly includes a pilot hole in the center and two mounting holes on the two ends, the pilot hole is rotationally matched with a cylindrical upper center plate of a car body for transmitting vertical and horizontal forces from the car body, and the two mounting holes are disposed above the two spring suspension devices, respectively. Each mounting hole receives a lower side bearing, and the lower side bearing is matched with a corresponding upper side bearing disposed on each side of the car body for transmitting the vertical load from the car body.

Abstract: Oral care compositions suitable for whitening and remineralizing teeth are described. The oral care compositions comprise a phosphate source and regeneration-source calcium salt having a particle size of five (5) microns or less so that in-situ hydroxyapatite may be generated upon use.

Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.

Abstract: A connector securing a liner to a scuff in a container sidewall is disclosed. The connector is adapted to receive and secure various thicknesses of liners and scuffs. The connector is made of a light weight, high strength flexible material and well suited to secure non-metallic scuffs and non-metallic linings. The connector includes a transition piece that utilizes clamping force (pre-tightening force) to connect two different thicknesses of panels made of continuous glass fiber reinforced thermoplastic material. The connector includes a thick lower opening adapted to secure the scuff and a thin upper opening adapted to secure the liner. In an exemplary embodiment of the invention, the width of the lower opening is between 5.0 mm and 5.5 mm while the width of the upper opening is between 1.5 mm and 2.0 mm.