Patents by Inventor Yong Xu

Yong Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9102650
    Abstract: According to embodiments of present disclosure, a method to produce a compound of Formula 19 is provided. Using this method, the compound of Formula 19 may be produced effectively.
    Type: Grant
    Filed: August 8, 2014
    Date of Patent: August 11, 2015
    Inventor: Yong Xu
  • Patent number: 9074196
    Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.
    Type: Grant
    Filed: January 8, 2013
    Date of Patent: July 7, 2015
    Assignee: New England Biolabs, Inc.
    Inventors: Zhenyu Zhu, Aine Quimby, Shuang-Yong Xu, Shengxi Guan, Hua Wei, Penghua Zhang, Dapeng Sun, Siu-hong Chan
  • Patent number: 9074197
    Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.
    Type: Grant
    Filed: January 8, 2013
    Date of Patent: July 7, 2015
    Assignee: New England Biolabs, Inc.
    Inventors: Zhenyu Zhu, Aine Quimby, Shuang-Yong Xu, Shengxi Guan, Hua Wei, Penghua Zhang, Dapeng Sun, Siu-hong Chan
  • Publication number: 20150188468
    Abstract: A dynamic braking system for an electric power system includes a switching device coupled to an electrical conductor. The switching device is configured to open and close with a plurality of predetermined frequencies. The dynamic braking system also includes an inductive device coupled to the switching device. The power losses of the inductive device are at least partially a function of the plurality of predetermined frequencies. The dynamic braking system further includes a dynamic braking controller coupled to the switching device. The dynamic braking controller is configured to open and close the switching device with at least one of the predetermined frequencies to dissipate electric power from the electrical conductor at a predetermined rate by regulating the power losses of the inductive device as a function of the predetermined frequencies.
    Type: Application
    Filed: July 12, 2012
    Publication date: July 2, 2015
    Inventors: Yong Xu, Robert Gregory Wagoner, Jun Zhu, Weng Li, Jincheng Huang
  • Publication number: 20150165363
    Abstract: A system for purifying mother liquid steam of polytetrafluoroethylene dispersion liquid comprises a concentration kettle (1), a defoaming pot (2), a gas-liquid separator (3) and a falling film absorption tower (4). A steam exit of the concentration kettle (1) is connected to an entrance of the defoaming pot (2). An exit of the defoaming pot (2) is connected to a feeding port of the gas-liquid separator (3). A gas exit of the gas-liquid separator (3) is connected to the falling film absorption tower (4). A liquid exit of the gas-liquid separator (3) is connected to the concentration kettle (1). A method for purifying mother liquid steam of polytetrafluoroethylene dispersion liquid by using the system is further provided.
    Type: Application
    Filed: August 2, 2012
    Publication date: June 18, 2015
    Applicant: ZHONGHAO CHENGUANG RESEARCH INSTITUTE OF CHEMICAL INDUSTRY COMPANY LIMITED
    Inventors: Jingang Zhang, Jia Li, Jinsong Zhang, Yong Xu, Xiulin Chen
  • Publication number: 20150171770
    Abstract: A power converter and a method for improving the output power of the power converter. The method includes independently selecting different gate resistor characteristics for the upper switching element and the lower switching element in the switching modules of the power converter to improve switching performance of both the upper and the lower switching element across a wide range of operating conditions, such as different voltages, currents, and/or operating temperatures.
    Type: Application
    Filed: April 24, 2012
    Publication date: June 18, 2015
    Applicant: General Electric Company
    Inventors: Robert Gregory Wagoner, Yong Xu, Li Weng, Hao Yu
  • Publication number: 20150155464
    Abstract: Method and apparatus are provided for improving the thermoelectric figure of merit (zT) for thermoelectric structures and devices based on topological insulators. In one novel aspect, the zT of the TI is increased by optimizing geometric sizes of the TI. In one embodiment, the zT is increased by increasing the length of the TI to be greater than the inelastic mean free path length. In another embodiment, the zT is increased by decrease the width of a 2D TI to be about three times the localized localization width ? of the boundary state of the TI, or to decrease the thickness of a 3D TI to be about three times of ?. In one novel aspect of the current invention, methods are provided to increase zT of the TI by substantially maximizing a relative thermoelectric-transport contribution of the boundary state with respect to the bulk states.
    Type: Application
    Filed: March 12, 2014
    Publication date: June 4, 2015
    Inventors: Yong Xu, Zhongxue Gan, Shou-Cheng Zhang
  • Patent number: 9048419
    Abstract: An arrangement that converts mechanical energy into electrical energy employs a base member and a cantilever member coupled thereto. The cantilever member has two piezoelectric layers with an air space therebetween. A proof mass is coupled to the cantilever member distal from the base member. The first and second piezoelectric layers are formed of lead zirconate titanate (PZT), and the output voltage of the cantilever member is proportional to the height of the air gap. A piezoresistive accelerometer that is useful for measuring mechanical vibration has a suspension beam and a piezoresistive layer be separated from the suspension beam. A method of monitoring an acoustic vibration utilizes a piezoresistive element having an air-spaced cantilever formed of a piezoelectric material in the vicinity of the system to be monitored and obtains an alternating voltage form the air-spaced cantilever of the piezoresistive element.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: June 2, 2015
    Assignee: WAYNE STATE UNIVERSITY
    Inventors: Yong Xu, Zhuo Wang, Qinglong Zheng
  • Patent number: 9034625
    Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.
    Type: Grant
    Filed: January 8, 2013
    Date of Patent: May 19, 2015
    Assignee: New England Biolabs, Inc.
    Inventors: Zhenyu Zhu, Aine Quimby, Shuang-Yong Xu, Shengxi Guan, Hua Wei, Penghua Zhang, Dapeng Sun, Siu-hong Chan
  • Publication number: 20150133411
    Abstract: Compounds, compositions and methods useful for treating ocular diseases are provided. In particular, antagonists of TRPV4, their synthesis, pharmaceutical compositions thereof and methods of treating ocular diseases such as glaucoma, are disclosed. Compounds of the invention include N-(3-(trifluoromethyl)phenyl)-2-methyl-1-(3-morpholinopropyl)-5-phenyl-1 H-pyrrole-3-carboxamide, as well as other 2-phenyl-pyrrole carboxamide derivates and indole carboxamide derivatives.
    Type: Application
    Filed: March 15, 2013
    Publication date: May 14, 2015
    Inventors: David Krizaj, Glenn D. Prestwich, Peter Barabas, Yong Xu, Daniel Ryskamp
  • Patent number: 9023634
    Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.
    Type: Grant
    Filed: January 8, 2013
    Date of Patent: May 5, 2015
    Assignee: New England Biolabs, Inc.
    Inventors: Zhenyu Zhu, Aine Quimby, Shuang-Yong Xu, Shengxi Guan, Hua Wei, Penghua Zhang, Dapeng Sun, Siu-hong Chan
  • Publication number: 20150112087
    Abstract: According to embodiments of present disclosure, a method to produce a compound of Formula 19 is provided. Using this method, the compound of Formula 19 may be produced effectively.
    Type: Application
    Filed: August 8, 2014
    Publication date: April 23, 2015
    Inventor: YONG XU
  • Publication number: 20140340862
    Abstract: An electronic device includes a main body, an installing assembly, a support, and a connecting assembly. The main body includes a shell and a display screen installed in the shell. The installing assembly is connected to a side of the shell opposite to the display screen. The connecting assembly is rotatably connected between the installing assembly and the support. The support includes a connecting pole and two opposite extending poles perpendicularly extending out from two opposite ends of the connecting pole. The connecting pole and the extending poles cooperatively bound a receiving space. The connecting assembly can be rotated to be received in the receiving space.
    Type: Application
    Filed: June 26, 2013
    Publication date: November 20, 2014
    Inventors: CHUN-YONG XU, HE-TAO HAN, LIU-SHA DENG, CHANG-SHENG ZHOU, GUANG-TIAN WAN, YONG-GAO LIAO, JUN-HUA TAN, SONG DENG, YI-SHENG LIN, WEN-KANG LO, YI-TING HSIEH, GUANG-YAO LEE
  • Publication number: 20140329807
    Abstract: The present invention provides protein kinase having one of the following structures (I), (II) or (III): or a stereoisomer, prodrug, tautomer or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer, autoimmune, inflammatory and other Pim kinase-associated conditions are also disclosed.
    Type: Application
    Filed: July 20, 2012
    Publication date: November 6, 2014
    Applicant: TOLERO PHARMACEUTICALS, INC.
    Inventors: Yong Xu, Benjamin Gary Brenning, Steven G. Kultgen, Xiaohui Liu, Michael Saunders, Koc-Kan Ho
  • Publication number: 20140321227
    Abstract: A method and an apparatus are provided. The apparatus is a hardware module that controls a power mode of a plurality of modules. The apparatus receives an indication of a desired operational frequency. Based on the received indication, the apparatus determines to switch from a first power mode associated with a first set of modules to a second power mode corresponding to the desired operational frequency and associated with a second set of modules. The apparatus enables modules in the second set of modules that are unassociated with the first power mode, stops traffic through the plurality of modules upon expiration of a time period after enabling the modules in the second set of modules that are unassociated with the first power mode, routes traffic through the second set of modules, and disables modules in the first set of modules that are unassociated with the second power mode.
    Type: Application
    Filed: May 23, 2013
    Publication date: October 30, 2014
    Applicant: QUALCOMM Incorporated
    Inventors: Zeeshan SYED, Nan CHEN, Yong XU, Michael Thomas FERTSCH, Boris ANDREEV, Zhiqin CHEN, Chang Ki KWON
  • Patent number: 8862206
    Abstract: The present invention relates to the field of medical imaging. More particularly, embodiments of the invention relate to methods, systems, and devices for imaging, including for tomography-based applications. Embodiments of the invention include, for example, a computed tomography based imaging system comprising: (a) at least one wide-beam gray-scale imaging chain capable of performing a global scan of an object and acquiring projection data relating to the object; (b) at least one narrow-beam true-color imaging chain capable of performing a spectral interior scan of a region of interest (ROI) of and acquiring projection data relating to the object; (c) a processing module operably configured for: (1) receiving the projection data; (2) reconstructing the ROI into an image by analyzing the data with a color interior tomography algorithm, aided by an individualized gray-scale reconstruction of an entire field of view (FOV), including the ROI; and (d) a processor for executing the processing module.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: October 14, 2014
    Assignee: Virginia Tech Intellectual Properties, Inc.
    Inventors: Ge Wang, Yong Xu, Alexander Cong, Haiou Shen, Wenxiang Cong, Lin Yang, Yang Lu
  • Patent number: 8798722
    Abstract: The present invention relates to the field of optical imaging and therapeutics. More particularly, embodiments of the present invention provide minimally-invasive Fiberoptic Microneedle Devices (FMDs) for light-based therapeutics, which physically penetrate tissue and deliver light directly into the target area below the skin surface (FIG. 1). A preferred embodiment of the invention is a fiberoptic microneedle device comprising: (a) one or more silica-based needles capable of guiding light and comprising a length of about 0.5-6 mm, a base having an outer diameter in the range of about 100-150 micron, and a tip having an outer diameter in the range of about 5-20 micron; (b) a support member to which the needles are secured; (c) a ferrule comprising one or more holes for each of the needles, wherein the ferrule is operably configured to provide mechanical support to each needle at all or some portion of the length of the needle.
    Type: Grant
    Filed: March 1, 2010
    Date of Patent: August 5, 2014
    Assignee: Virginia Tech Intellectual Properties, Inc.
    Inventors: Christopher Rylander, Thomas A. Campbell, Ge Wang, Yong Xu, Mehmet Alpaslan Kosoglu
  • Publication number: 20140183669
    Abstract: A resonant sensor is provided. The resonant sensor may have a structure including a base portion, a mass portion, and a mechanical beam connecting the base portion to the mass portion. In addition, the structure may include a first sensing beam formed from a sensing material responsive to mechanical strain where a gap is formed between the sensing beam and the mechanical beam.
    Type: Application
    Filed: March 25, 2011
    Publication date: July 3, 2014
    Applicant: Wayne State University
    Inventors: Yong Xu, Qinglong Zeng, Yating Hu, Yefa Li, Hongen Tu
  • Patent number: 8759384
    Abstract: Compounds represented by Formula I and II, or pharmaceutically acceptable salts thereof: inhibit bacterial 2-epimerase and are useful anti-infective agents.
    Type: Grant
    Filed: May 11, 2009
    Date of Patent: June 24, 2014
    Inventors: David J. Bearss, Hariprasad Vankayalapati, Yong Xu, Charles Erec Stabbins, Vincent A. Fischetti
  • Publication number: 20140154778
    Abstract: Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer.
    Type: Application
    Filed: December 20, 2013
    Publication date: June 5, 2014
    Applicant: NEW ENGLAND BIOLABS, INC.
    Inventors: Zhenyu Zhu, Aine Quimby, Shengxi Guan, Dapeng Sun, Yishu Huang, Xuhui Lai, Siu-hong Chan, Xianghui Li, Shuang-Yong Xu, Chunhua Zhang