Abstract: The present disclosure provides a display panel and a display device. The display panel includes a plurality of pixel units distributed in an array. The pixel unit includes: a pixel driver circuit configured to provide a driving current, a plurality of sub-pixels configured to emit light under an action of the driving current, and a switching circuit including a plurality of switching units arranged in correspondence with the plurality of sub-pixels. The switching unit is connected in series between the pixel driver circuit and a corresponding sub-pixel, a control end of the switching unit is configured to receive a switching signal, a first end of the switching unit is connected to the pixel driver circuit, a second end of the switching unit is connected to the corresponding sub-pixel, and the switching unit conducts a communication path between the sub-pixel and the pixel driver circuit in response to the switching signal.

Abstract: The present disclosure provides antibody drug conjugates comprising antibodies and antigen-binding fragments thereof that bind to human CEA and a linker-payload, a pharmaceutical composition comprising the anti-CEA antibody drug conjugate, and use of the anti-CEA antibody drug conjugate for treating a CEA-related diseases or disorders.

Abstract: The present disclosure provides an underwater detection method for contact leakage of a tunnel joint of a dam culvert, including: obtaining an underwater image sequence of the culvert by an underwater robot; preprocessing and registering the underwater image sequence; extracting particle information appearing in the underwater image sequence based on the registered underwater image sequence; constructing a three-dimensional fluid velocity distribution map based on the particle information, and determining leakage situation according to the three-dimensional fluid velocity distribution map; and superimposing the three-dimensional fluid velocity distribution map on a preconfigured three-dimensional culvert model, and rendering and displaying it.

Abstract: Systems and methods of message filtering in a multi-region multi-active architecture are provided. A client device receives a data message, the data message comprising a region tag and an account tag. The client device determines whether the region tag corresponds to a region server assigned to serve the client device. In response to determining the region tag corresponds to the region server assigned to serve the client device, the client device determines whether an account identification (ID) associated with the client device matches the account tag of the data message. In response to determining the account ID matches the account tag, the client device consumes the data message.

Abstract: A display panel and a display apparatus. The display panel includes a substrate, and pixel islands (Pi) arranged in an array on the substrate, and at least one pixel island (Pi) includes a plurality of pixel drive circuits (10) and a plurality of light emitting devices, wherein a light emitting device includes a first electrode (20), and at least one pixel drive circuit (10) is electrically connected with at least one light emitting device; first electrodes (20) of a plurality of light emitting devices on a same pixel island are arranged in a first direction, and an orthographic projection of a first electrode (20) of at least one light emitting device on the substrate is at least partially overlapped with an orthographic projection of at least two pixel drive circuits (10) on the substrate.

Abstract: The present disclosure provides for multi-specific antibodies and antigen-binding fragments thereof that bind to human MUC1 and CD16A, pharmaceutical compositions comprising said antibodies, and use of the antibodies or the compositions for treating a disease, such as cancer.

Abstract: The present disclosure provides a shift register unit, a gate driving circuit and a display device. The shift register unit provided by the present disclosure includes: an input sub-circuit, an output sub-circuit, at least one pull-down control sub-circuit, at least one pull-down sub-circuit, at least one first noise reduction sub-circuit, and a reverse bias sub-circuit; the reverse bias sub-circuit is configured to control transistors in at least part of sub-circuits connected to a pull-up node to be in a reverse bias state through a power voltage signal in response to a potential of the pull-up node, or control the transistors in at least part of the sub-circuits connected to the pull-up node to be in the reverse bias state through a cascade signal in response to a potential of a cascade signal terminal.

Abstract: The present disclosure provides an underwater detection method for contact leakage of a tunnel joint of a dam culvert, including: obtaining an underwater image sequence of the culvert by an underwater robot; preprocessing and registering the underwater image sequence; extracting particle information appearing in the underwater image sequence based on the registered underwater image sequence; constructing a three-dimensional fluid velocity distribution map based on the particle information, and determining leakage situation according to the three-dimensional fluid velocity distribution map; and superimposing the three-dimensional fluid velocity distribution map on a preconfigured three-dimensional culvert model, and rendering and displaying it.

Abstract: A display substrate is provided. The display substrate includes a quantum dots layer having a plurality of quantum dots. The quantum dots layer includes a plurality of quantum dots blocks respectively in a plurality of first apertures. A respective quantum dots block of the plurality of quantum dots blocks includes a first region and a second region. A concentration of a respective product of a respective reactant produced by a respective reaction in the first region is greater than a concentration of the respective product of the respective reactant produced by the respective reaction in the second region. The respective reaction is one of a dimerization, oligomerization, polymerization, a condensation reaction, or any combination thereof.

Abstract: The disclosure provides a quantum dot mixture, a quantum dot light emitting layer and a preparation method thereof, relates to the field of display technology. The preparation method of quantum dot light emitting layer includes: providing a substrate; forming a quantum dot film layer on one side of the substrate, which comprises a first quantum dot body-first ligand and a second quantum dot body-second ligand; exposing a predetermined region of the substrate to form a cross-linkage or a salt insoluble in the developer via a reaction between the first ligand and the second ligand in the predetermined region of the quantum dot film layer; and developing to remove the quantum dot film layer in the non-predetermined region of the substrate, and obtain the quantum dot light emitting layer. The disclosure provides a basis for the formation of the quantum dot light emitting layer using photolithography technology.

Abstract: A quantum dots light-emitting device and a manufacturing method thereof are provided, which includes: an electron transport layer, an auxiliary layer, and a quantum dot light-emitting layer sequentially stacked, the quantum dot light-emitting layer includes quantum dots, surfaces of the quantum dots are provided with a first ligand, the first ligand includes a first functional group connected to the quantum dots and a second functional group away from the quantum dots; surfaces of the quantum dots in contact with the first ligand have a compound formed by a metal element and a nonmetallic element, a material of the auxiliary layer includes at least one selected from a group consisting of a compound containing the second functional group, a compound containing the metal element, and a compound containing the nonmetallic element. The auxiliary layer firstly occupies a site where unnecessary quantum dots may remain.

Abstract: A display substrate, a display panel and a method for manufacturing the display substrate are provided. The display substrate comprises a backing substrate and a plurality of pixel areas formed on the backing substrate, wherein the display substrate further comprises a quantum dot layer, the quantum dot layer comprises a plurality of quantum dot units located in the plurality of pixel areas respectively, wherein the quantum dot units comprise a matrix layer and quantum dots dispersed in the matrix layer, the matrix layer comprises a central region and a peripheral region disposed around the central region, the peripheral region comprises a polymer of photocurable monomers, and the central region comprises unpolymerized photocurable monomers.

Abstract: A method for identifying high-quality lithium-potassium-rich brine reservoirs based on parameter sensitivity analysis is provided. Basic characteristics of a brine reservoir area are determined. The sensitive parameter analysis of the brine reservoir area is performed by rock physics modeling and cross-plotting of logging curves to determine a rock physics parameter range and a logging parameter range of the brine reservoir area. The relationship between the wave impedance and the water saturation based on the rock physics model. A coordinate range of a water-rich reservoir is determined based on the inversion result of the water saturation. Within the coordinate range of the water-rich reservoir, a coordinate range of the lithium-potassium-rich brine reservoir is determined based on the natural gamma inversion result obtained by waveform phase-controlled inversion, so as to achieve geophysical identification and prediction of high-quality brine reservoirs in the marine strata.

Abstract: A battery protection chip, a polling detection method and a polling detection circuit based on a battery protection chip are provided. The circuit includes: a polling signal generator generating first and second selection signals based on a basic clock signal, a plurality of state signals and a priority of a plurality of detection items. An input array selector selects one of a plurality of reference signals and one of a plurality of feedback signals to output to a comparator based on the first selection signal; the comparator compares the feedback reference signals and outputs an indication signal. An output sampler samples the indication signal according to the second selection signal and updates the plurality of state signals according to a sampling result.

Abstract: The present disclosure provides an array substrate, a manufacturing method thereof, and a display device. The array substrate includes a base substrate including a plurality of sub-pixels arranged in an array, a patterned metal oxide layer on the base substrate and in the plurality of sub-pixels, a portion of the metal oxide layer in any one of the plurality of sub-pixels being spaced apart from a portion of the metal oxide layer in another sub-pixel adjacent to the any one sub-pixel, and a patterned light-emitting layer on a side of the metal oxide layer away from the base substrate and in the plurality of sub-pixels. The metal oxide layer includes at least one of magnesium element or calcium element, and the light-emitting layer includes a photosensitive material and is in contact with the metal oxide layer.

Abstract: A pixel circuit includes a pixel driving circuit and a bonding unit connected thereto. The bonding unit includes a first bonding terminal group and at least one second bonding terminal group that are arranged in parallel, and the first bonding terminal group and a second bonding terminal group are configured to bond light-emitting devices. The first bonding terminal group includes a first terminal and a second terminal, and the second bonding terminal group includes a third terminal and a fourth terminal. The first terminal and the third terminal are connected, and are both connected to the pixel driving circuit; the second terminal and the fourth terminal are connected, and are both connected to a set voltage signal line.

Abstract: An application of a channel blocker in preparation of drugs for treating and/or preventing liver fibrosis is provided, belonging to the field of biomedical technology. A new use of phenytoin sodium is provided. It is demonstrated that at the cell level, the phenytoin sodium can improve liver fibrosis by regulating autophagy and thus affecting the activation of hepatic stellate cells. In this situation, the efficacy of the phenytoin sodium on liver fibrosis is verified at the animal level by establishing a disease model, and the phenytoin sodium can be used to prepare drugs for treating and/or preventing liver fibrosis.

Abstract: An ion channel blocker for treatment and/or prevention of hepatic fibrosis is provided. Based on the fact that the activation of hepatic stellate cells is an important link in anti-hepatic fibrosis, it is found that gliclazide has the effect of inhibiting the activation of hepatic stellate cells by in vitro and in vivo experiments. Further exploration reveals that gliclazide mainly inhibits the activation of hepatic stellate cells by inhibiting autophagy pathways, and thus the gliclazide can be used to prepare medicaments for treatment and/or prevention of hepatic fibrosis.

Abstract: An application of potassium ion (K+) channel blocker in preparation of drugs for treating liver fibrosis is provided, which relates to the field of medical technologies. The K+ channel blocker is sotalol, the sotalol is originally used as an antiarrhythmic drug in clinic and has a property of inhibiting K+ channels. Experiments show that sotalol can effectively inhibit liver fibrosis and reduce expression of fibrosis-related protein alpha-smooth muscle actin (?-SMA), specifically by regulating expression and/or function of autophagy and epithelial-mesenchymal transition (EMT) molecules to achieve inhibition of hepatic stellate cell (HSC) fibrosis, so as to provide a new drug choice for clinical treatment of the liver fibrosis.

Abstract: To increase performance, a non-volatile storage apparatus reduces the amount of time needed for program verify by eliminating a pause in the raising of word line voltages that has been used to allow the channels of memory cells to discharge. To compensate for the removal of the time previously used to allow the channels of memory cells to discharge without experiencing a disturb, a source line that is in communication with the channels is lowered from a source voltage applied to support programming to a source voltage applied to support sensing (for program verify) earlier than in previous designs such that the source line reaches the source voltage applied to support sensing (for program verify) prior to applying the verify reference voltage to the selected word line for program verify.