Abstract: The present disclosure provides antibody drug conjugates comprising antibodies and antigen-binding fragments thereof that bind to human CEA and a linker-payload, a pharmaceutical composition comprising the anti-CEA antibody drug conjugate, and use of the anti-CEA antibody drug conjugate for treating a CEA-related diseases or disorders.

Abstract: The present disclosure provides an underwater detection method for contact leakage of a tunnel joint of a dam culvert, including: obtaining an underwater image sequence of the culvert by an underwater robot; preprocessing and registering the underwater image sequence; extracting particle information appearing in the underwater image sequence based on the registered underwater image sequence; constructing a three-dimensional fluid velocity distribution map based on the particle information, and determining leakage situation according to the three-dimensional fluid velocity distribution map; and superimposing the three-dimensional fluid velocity distribution map on a preconfigured three-dimensional culvert model, and rendering and displaying it.

Abstract: Provided is an efficient and energy-saving building slurry stirring device. The device includes a grouting assembly, which includes a base, a storage tank, a discharge pipe, a grouting pump and a control box. The storage tank is arranged at the top of the base, the discharge pipe is located at one side of the storage tank, the grouting pump is arranged on the discharge pipe, and the control box is fixed to the top of the base. When the fluidity of a grouting material in the storage tank is reduced due to solidification, the stirring assembly can stir the grouting material in the storage tank. Then, the stirring assembly stops stirring the grouting material to save energy. After the grouting is completed, an inner wall of the storage tank can be cleaned by the stirring assembly.

Abstract: The present application provides a backlight module and a liquid crystal display device; the first portion of the slit adhesive is formed with a notch, so that when internal stress generates in the slit adhesive due to environmental changes, the internal stress can be released through the notch, thereby preventing the slit adhesive from warping and improving the yield of the backlight module.

Abstract: Systems and methods of message filtering in a multi-region multi-active architecture are provided. A client device receives a data message, the data message comprising a region tag and an account tag. The client device determines whether the region tag corresponds to a region server assigned to serve the client device. In response to determining the region tag corresponds to the region server assigned to serve the client device, the client device determines whether an account identification (ID) associated with the client device matches the account tag of the data message. In response to determining the account ID matches the account tag, the client device consumes the data message.

Abstract: The present invention provides compounds of Formula I: or pharmaceutically acceptable salts thereof, as well as their compositions and methods of use, that inhibit the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

Abstract: A first apparatus including a processor; and a memory storing computer-executable instructions that when executed by the processor cause the first apparatus to: receive, from a second apparatus, information including Discontinuous Reception (DRX) configurations, wherein one of the DRX configurations is a first active DRX configuration and other DRX configurations are candidate DRX configurations; perform Physical Downlink Control Channel (PDCCH) monitoring in accordance with the first active DRX configuration; monitor signaling from the second apparatus for an indication that is used for adapting the first active DRX configuration; receive from the second apparatus an indication for adapting the first active DRX configuration into a second active DRX configuration; based on the indication for adapting the first active DRX configuration into the second active DRX configuration, adapt the first active DRX configuration into the second active DRX configuration; and perform PDCCH monitoring in accordance with the

Abstract: Methods and apparatus are described for configuring desired network capabilities in a service-based network, including a method for a UE to initiate a network capability based registration to configure its desired network capabilities, a method for UEs to initiate a network capability based registration update when UEs are already registered to the network and want to dynamically re-configure their network capabilities, and a method for a network capability based UE configuration update, which allows NFs or ASs to initiate updating the network capabilities in a network slice for the UE.

Abstract: The present invention provides a high-stability deep-sea buoy platform including a mast tube housing an attitude sensor used to monitor the tilt angle of the deep-sea buoy platform; a plurality of buoyancy tubes symmetrically and equally spaced around the mast tube; the buoyancy tube includes an elastic float and a water tank; the cross-section of the elastic float is ring-shaped; the elastic float being fitted around the outer side of the upper part of the water tank; the water tank is cylindrical and the interior of the water tank is divided into an upper layer and a lower layer, and the lower layer containing ballast water; each water tank is connected to the other water tanks via pipelines, each of the pipelines equipped with a flow valve; and a damping plate is horizontally connected between the bottoms of adjacent water tanks.

Abstract: A display panel and a display apparatus. The display panel includes a substrate, and pixel islands (Pi) arranged in an array on the substrate, and at least one pixel island (Pi) includes a plurality of pixel drive circuits (10) and a plurality of light emitting devices, wherein a light emitting device includes a first electrode (20), and at least one pixel drive circuit (10) is electrically connected with at least one light emitting device; first electrodes (20) of a plurality of light emitting devices on a same pixel island are arranged in a first direction, and an orthographic projection of a first electrode (20) of at least one light emitting device on the substrate is at least partially overlapped with an orthographic projection of at least two pixel drive circuits (10) on the substrate.

Abstract: The present disclosure provides for multi-specific antibodies and antigen-binding fragments thereof that bind to human MUC1 and CD16A, pharmaceutical compositions comprising said antibodies, and use of the antibodies or the compositions for treating a disease, such as cancer.

Abstract: Compositions and methods are provided herein for treating intestinal glycocalyx dysfunction. The composition can comprise a chito-oligosaccharide (COS), and optionally a human milk oligosaccharide (hMO) in an amount sufficient to maintain an intestinal glycocalyx and a pharmaceutically acceptable carrier. The composition can be formulated as an oral dosage form or a parenteral dosage form. The method can comprise identifying intestinal glycocalyx dysfunction in the subject. The method can further comprise administering to the subject a COS in an amount and at a frequency sufficient to prevent, stabilize and reverse damage in the intestinal glycocalyx.

Abstract: A Sidelink AS group management function is disclosed for a UE to discover group members and organize them into AS layer sub-groups based on the AS layer group context information. A centralized Sidelink AS group management is disclosed that the Sidelink AS Group Manager discovers group members and organizes them into AS layer sub-groups for a UE. A Subgroup formation and configuration procedure is disclosed that SL AS Group Manager organizes the ULG into AS layer sub-groups, configures UE-to-UE relays for each UE in the ULG and sends the AS group management information to the UE. A distributed Sidelink AS group management method is disclosed that each UE discovers its group members and organizes the ULG into AS layer sub-groups. New Layer 2 structures and procedures are disclosed to enhance bearer management for Sidelink groupcast communications.

Abstract: An electronic device that is configured to schedule transmission of data to at least one other electronic device via sidelink resources in a wireless communication network; identify that the scheduled transmission of the data is preempted by another transmission occurring within at least a part of the sidelink resources; and control transmission of the data to at least one other electronic device based on the identifying.

Abstract: A discoverer user equipment sends a discovery announcement to a discoveree user equipment via a sidelink service. The announcement includes criteria for a service sought by discoverer. The discoveree assesses the announcement and may respond to the discoverer. The discovery announcement may be a target search discovery announcement or a self-advertisement discovery announcement, and may be unicast, groupcast, or broadcast. The discoverer and discoveree may perform synchronization in support of V2X sidelink communication and may collect driving information pertaining to vehicles associated with the discoverer and discoveree, respectively, such as driving intention, positioning, and environment information. The discoverer may request an authorization for the discovery announcement, and the request may include the driving information.

Abstract: The present disclosure provides a shift register unit, a gate driving circuit and a display device. The shift register unit provided by the present disclosure includes: an input sub-circuit, an output sub-circuit, at least one pull-down control sub-circuit, at least one pull-down sub-circuit, at least one first noise reduction sub-circuit, and a reverse bias sub-circuit; the reverse bias sub-circuit is configured to control transistors in at least part of sub-circuits connected to a pull-up node to be in a reverse bias state through a power voltage signal in response to a potential of the pull-up node, or control the transistors in at least part of the sub-circuits connected to the pull-up node to be in the reverse bias state through a cascade signal in response to a potential of a cascade signal terminal.

Abstract: The present disclosure provides an underwater detection method for contact leakage of a tunnel joint of a dam culvert, including: obtaining an underwater image sequence of the culvert by an underwater robot; preprocessing and registering the underwater image sequence; extracting particle information appearing in the underwater image sequence based on the registered underwater image sequence; constructing a three-dimensional fluid velocity distribution map based on the particle information, and determining leakage situation according to the three-dimensional fluid velocity distribution map; and superimposing the three-dimensional fluid velocity distribution map on a preconfigured three-dimensional culvert model, and rendering and displaying it.

Abstract: A display substrate is provided. The display substrate includes a quantum dots layer having a plurality of quantum dots. The quantum dots layer includes a plurality of quantum dots blocks respectively in a plurality of first apertures. A respective quantum dots block of the plurality of quantum dots blocks includes a first region and a second region. A concentration of a respective product of a respective reactant produced by a respective reaction in the first region is greater than a concentration of the respective product of the respective reactant produced by the respective reaction in the second region. The respective reaction is one of a dimerization, oligomerization, polymerization, a condensation reaction, or any combination thereof.

Abstract: The present disclosure provides a method for opening a digital wallet, a wallet application terminal, and a system. The method comprises: acquiring, from a digital currency issuer agency server, a list of operating agency servers that can open a digital wallet and displaying the list of operating agency servers, so that a user selects a target operating agency server from the list of operating agency servers; communicating with the target operating agency server, so that the target operating agency server verifies the user; when the verification is passed, sending a digital wallet opening request to the digital currency issuer agency server, so that the digital currency issuer agency server notifies the target operating agency server to perform a digital wallet opening operation, or sending a digital wallet opening request to the target operating agency server, so that the target operating agency server performs a digital wallet opening operation.

Abstract: Multicast/Broadcast Service (MBS) for user equipments (UE) in Radio Resource Control (RRC) idle/inactive modes via signally of MBS frequency ranges and/or switching between frequency ranges as required. Bandwidth Part (BWP) operation for MBS in RRC_IDLE and RRC_INACTIVE states may be implemented using a dedicated MBS BWP or by sharing a frequency range with other operations. An MBS frequency range may be wider or narrower than an initial BWP used by a UE, for example. MBS frequency range configure may be achieved in a number of ways, such as via Control Resource Set (CORESET), search space, and/or PDCCH monitoring occasions pattern settings for MBS in RRC idle/inactive. Downlink scheduling without dynamic grant for MBS in RRC idle/inactive may include configured scheduling and/or semi-persistent scheduling. Downlink repetition for MBS in RRC idle/inactive may include PDSCH repetition and/or PDCCH repetition.