CA125 gene and its use for diagnostic and therapeutic interventions

Abstract

The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is assembled by combining five genomic exons, four very short amino terminal sequences and one extraordinarily large exon. This domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. Additionally, an amino terminal extension is present, which comprises four genomic exons. The amino acid composition of the amino terminal extension was found to be consistent with the amino acid composition of the amino terminal domain. The molecular structure is dominated by a repeat domain comprising 156 amino acid repeat units, which encompass the epitope binding sites. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure. More specifically, this invention is directed to a CA125 cDNA sequence which can be introduced into animal or human cells to achieve transcription or expression of the cDNA.

Description

BACKGROUND OF THE INVENTION

[0001] This application is a continuation-in-part of U.S. Provisional Application Serial No. 60/284,175 filed Apr. 17, 2001, U.S. Provisional Application Serial No. 60/299,380 filed Jun. 19, 2001, U.S. Non-Provisional Application No. 09/965,738 filed Sep. 27, 2001, and U.S. Provisional Application Serial No. 60/345,180. This application is a continuation-in-part of provisional application 60/427,045 (filed Nov. 15, 2002), all of which are hereby specifically incorporated by reference. Applicants hereby specifically claims the benefit of these prior filed applications under 35 U.S.C. § 119(e), and 120.

[0002] The present invention relates generally to the cloning, identification, and expression of the CA125 gene's glycosylated amino terminal domain, the multiple repeat domain, and the carboxy terminal domain in vitro and, more specifically, to the use of recombinant CA125 with epitope binding sites for diagnostic and therapeutic purposes. Additionally, the genomic DNA, a molecule encoding a 5′ upstream region of CA125 and a genomic DNA sequence for the amino terminal, extra cellular repeats and carboxy terminal of CA125 has been determined.

[0003] CA125 is an antigenic determinant located on the surface of ovarian carcinoma cells with essentially no expression in normal adult ovarian tissue. Elevated in the sera of patients with ovarian adenocarcinoma, CA125 has played a critical role for more than 15 years in the management of these patients relative to their response to therapy and also as an indicator of recurrent disease.

[0004] It is well established that CA125 is not uniquely expressed in ovarian carcinoma, but is also found in both normal secretory tissues and other carcinomas (i.e., pancreas, liver, colon) [Hardardottir H et al., Distribution of CA125 in embryonic tissue and adult derivatives of the fetal periderm, Am J Obstet. Gynecol. 163;6(1):1925-1931 (1990); Zurawski V R et al., Tissue distribution and characteristics of the CA125 antigen, Cancer Rev. 11-12:102-108 (1988); and O'Brien T J et al., CA125 antigen in human amniotic fluid and fetal membranes, Am J Obstet Gynecol. 155:50-55, (1986); Nap M et al., Immunohistochemical characterization of 22 monoclonal antibodies against the CA125 antigen: 2nd report from the ISOBM TD-1 workshop, Tumor Biology 17:325-332 (1996)]. Notwithstanding, CA125 correlates directly with the disease status of affected patients (i.e., progression, regression, and no change), and has become the “gold standard” for monitoring patients with ovarian carcinoma [Bast R C et al., A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer, N Engl J Med. 309:883-887 (1983); and Bon G C et al., Serum tumor marker immunoassays in gynecologic oncology: Establishment of reference values, Am J Obstet. Gynecol. 174:107-114 (1996)]. CA125 is especially useful in post-menopausal patients where endometrial tissue has become atrophic and, as a result, is not a major source of normal circulating CA125.

[0005] During the mid 1980's, the inventor of the present invention and others developed M11, a monoclonal antibody to CA125. M11 binds to a dominant epitope on the repeat structure of the CA125 molecule [O'Brien T J et al., New monoclonal antibodies identify the glycoprotein carrying the CA125 epitope, Am J Obstet Gynecol 165:1857-64 (1991)]. More recently, the inventor and others developed a purification and stabilization scheme for CA125, which allows for the accumulation of highly purified high molecular weight CA125 [O'Brien T J et al., More than 15 years of CA125: What is known about the antigen, its structure and its function, Int J Biological Markers 13(4):188-195 (1998)].

[0006] Considerable progress has been made over the years to further characterize the CA125 molecule, its structure and its function. The CA125 molecule is a high molecular weight glycoprotein with a predominance of O-linked sugar side chains. The native molecule exists as a very large complex (˜2-5 million daltons). The complex appears to be composed of an epitope containing CA125 molecule and binding proteins which carry no CA125 epitopes. The CA125 molecule is heterogenous in both size and charge, most likely due to continuous deglycosylation of the side chains during its life-span in bodily fluids. The core CA125 subunit is in excess of 200,000 daltons, and retains the capacity to bind both OC125 and M11 class antibodies.

[0007] Despite the advances in detection and quantitation of serum tumor markers like CA125, the majority of ovarian cancer patients are still diagnosed at an advanced stage of the disease—Stage III or IV. Further, the management of patients' responses to treatment and the detection of disease recurrence remain major problems. There, thus, remains a need to significantly improve and standardize current CA125 assay systems. Further, the development of an early indicator of risk of ovarian cancer will provide a useful tool for early diagnosis and improved prognosis.

SUMMARY OF THE INVENTION

[0008] Thus, it is an object of the present invention to provide a recombinant CA125 cDNA molecule which can be introduced into animals or human cells to achieve transcription or expression of the cDNA. The utility of knowing the DNA sequence of a specific gene is that a recombinant protein can be produced which can be used as an easily renewable source of that gene or a portion of the gene. Producing and purifying recombinant protein is easier and can produce greater quantities of protein than purifying native protein from patients. The recombinant protein can then be used to produce antibodies to the gene, both polyclonal and monoclonal. The recombinant protein can also be used as a positive control in test kits and experiments.

[0009] The genomic sequence for CA125 and a 5′ upstream region has been determined. A DNA sequence showing the 5′ upstream region and the amino terminal portion of the CA125 molecule is set out in Table 1 and SEQ ID NO: 1. The extracellular amino terminal domain is made of exons: Exon 1 from 2205-11679; Exon 2 from 13464-13570; Exon 3 from 16177-34419; Exon 4 from 34575-38024; Exon 5 from 38689-38800; Exon 6 from 40578-45257; Exon 7 from 47360-47395; Exon 8 from 52407-52442; Exon 9 from 52686-52744 as set out in SEQ ID NO: 1. A DNA sequence showing the extracellular repeat portion of the CA125 molecule is set out in Table 2 and SEQ ID NO: 2. The genomic repeats are made of exons: Exon R1 from 1-130; Exon R2 from 442-510; Exon R3 from 5479-5652; Exon R4 from 6301-6334; Exon R5 from 6593-6657; Exon R1 from 7558-7683; Exon R from 8216-8284; Exon R3 from 8877-9050; Exon R4 from 9380-9413; Exon R5 from 9675-9739; Exon R1 from 10201-10291; Exon R2 from 10524-10592; Exon R3 from 11200-11373; Exon R4 from 11722-11755; Exon R5 from 12016-12036; Exon R1 from 12169-12295; Exon R2 from 12532-12600; Exon R3 from 13219-13392; Exon R4 from 13723-13756; Exon R5 from 14016-14077; Exon R1 from 15001-15126; Exon R2 from 15367-15435; Exon R1 from 15648-15773; Exon R2 from 16002-16070; Exon R3 from 16653-16826; Exon R4 from 17158-17191; Exon R5 from 17453-17517; Exon R1 from 18532-18657; Exon R2 from 18888-18956; Exon R3 from 19633-19806; Exon R4 from 20141-20176; Exon R5 from 20387-20449; Exon R1 from 21609-21731; Exon R2 from 21940-22008; Exon R3 from 22605-22778; Exon R4 from 23109-23142; Exon R1 from 29046-29168; Exon R2 from 29266-29334; Exon R3 from 33917-34090; Exon R4 from 36702-36734; Exon R5 from 38270-38320;Exon R1 from 39104-39224; Exon R2 from 39315-39383; Exon R3 from 39532-39705; Exon R4 from 41862-41992. A DNA sequence showing the carboxy terminal domain of the CA125 molecule is set out in Table 3 and SEQ ID NO: 3. The carboxy terminal portion is made of exons: Exon Cl from 1-66; Exon C2 from 1802-1947; Exon C3 from 4198-4350; Exon C4 from 4679-4747; Exon C5 from 6811-6978; Exon C6 from 11232-11270; Exon C7 from 11594-11677; Exon C8 from 14095-14187 as set out in SEQ ID NO: 3. A full length cDNA molecule for CA125 is set out in Table 4 and SEQ ID NO: 4. A CA125 protein is set out in Table 5 and SEQ ID NO: 5.

[0010] Now that the DNA sequence which encodes CA125 has been discovered known synthetic methods can be employed to prepare DNA molecules containing portions of the sequence. Conventional cloning vehicles, such as plasmids, viruses, or bacteria phages can be modified using known methods so as to produce novel cloning vehicles which contain cDNA encoding, CA125, analogs or mutants thereof. Similarly, such cloning vehicles can be modified or engineered so that they contain DNA molecules from Table 4 and SEQ ID NO: 4 or segments substantially similar thereto. The DNA molecule inserted may be made by various methods including enzymatic or chemical synthesis.

[0011] The CA125 gene has been cloned and multiple repeat sequences as well as the glycosylated amino terminal and the carboxy terminus have been identified. CA125 requires a transcript of more than 35,000 bases and occupies approximately 150,000 bp on chromosome 19p 13.2. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is assembled by combining five genomic exons, four very short amino terminal sequences and one extraordinarily large exon. This domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. Additionally, an amino terminal extension is present, which comprises four genomic exons. Analysis of the amino terminal extension revealed that its amino acid composition is consistent with the amino acid composition of the amino terminal domain.

[0012] Perhaps even more significantly, the multiple repeat domains of CA125 or other domains could also be used for the development of a potential vaccine for patients with ovarian cancer. In order to induce cellular and humoral immunity in humans to CA125, murine antibodies specific for CA125 were utilized in anticipation of patient production of anti-ideotypic antibodies, thus indirectly allowing the induction of an immune response to the CA125 molecule. With the availability of recombinant CA125, especially domains which encompass epitope binding sites for known murine antibodies, it will be feasible to more directly stimulate patients' immune systems to CA125 and, as a result, extend the life of ovarian carcinoma patients.

[0013] The recombinant CA125 of the present invention may also be used to develop therapeutic targets. Molecules like CA125, which are expressed on the surface of tumor cells, provide potential targets for immune stimulation, drug delivery, biological modifier delivery or any agent which can be specifically delivered to ultimately kill the tumor cells. Humanized or human antibodies to CA125 epitopes could be used to deliver all drug or toxic agents including radioactive agents to mediate direct killing of tumor cells. Natural ligands having a natural binding affinity for domains on the CA125 molecule could also be utilized to deliver therapeutic agents to tumor cells.

[0014] CA125 expression may further provide a survival or metastatic advantage to ovarian tumor cells. Antisense oligonucleotides derived from the CA125 repeat sequences could be used to down-regulate the expression of CA125. Further, antisense therapy could be used in association with a tumor cell delivery system of the type described above.

[0015] Recombinant domains of the CA125 molecule also have the potential to identify small molecules, which bind to individual domains of the CA125 molecule. These small molecules could also be used as delivery agents or as biological modifiers.

[0016] In another aspect of the present invention, an isolated nucleic acid of the CA125 gene is disclosed, which comprises a nucleotide sequence selected from the group consisting of: (a) the nucleotide sequences set forth in SEQ ID NOS: 1, 2, 3 and 4; (b) a nucleotide sequence having at least 70% sequence identity to any one of the sequences in (a); (c) a degenerate variant of any one of (a) to (b); and (d) a fragment of any one of (a) to (c).

[0017] In another aspect of the present invention, an isolated nucleic acid of the CA125 gene, comprising a sequence that encodes a polypeptide with the amino acid sequence selected from the group consisting of: (a) the amino acid sequences set forth in SEQ ID NO: 5; (b) an amino acid sequence having at least 50% sequence identity to any one of the sequences in (a); (c) a conservative variant of any one of (a) to (b); and (d) a fragment of any one of (a) to (c).

[0018] The vector may be a cloning vector, a shuttle vector, or an expression vector. A cultured cell comprising the vector is also contemplated.

[0019] More specifically, this invention relates to a purified antibody that selectively binds to an epitope in the CA125 protein of SEQ ID NO: 5. Similarly, the purified antibody selectively binds to an amino acid sequence having at least 50% sequence identity to said sequence; the purified antibody selectively binds to an amino acid sequence having at least 60% sequence identity to said sequence; the purified antibody selectively binds to an amino acid sequence having at least 70% sequence identity to said sequence; the purified antibody selectively binds to an amino acid sequence having at least 80% sequence identity to said sequence; and the purified antibody selectively binds to an amino acid sequence having at least 90% sequence identity to said sequence. Additionally, purified antibody can be a conservative variant of the amino acid sequence set forth in SEQ ID NO: 5 or a fragment thereof.

DETAILED DESCRIPTION OF THE INVENTION

[0020] In accordance with the present invention, conventional molecular biology, microbiology, and recombinant DNA techniques may be used that will be apparent to those skilled in the relevant art. Such techniques are explained fully in the literature (see, e.g., Maniatis, Fritsch & Sambrook, “Molecular Cloning: A Laboratory Manual (1982); “DNA Cloning: A Practical Approach,” Volumes I and II (D. N. Glover ed. 1985); “Oligonucleotide Synthesis” (M. J. Gait ed. 1984); “Nucleic Acid Hybridization” (B. D. Hames & S. J. Higgins eds. (1985)); “Transcription and Translation” (B. D. Hames & S. J. Higgins eds. (1984)); “Animal Cell Culture” (R. I. Freshney, ed. (1986)); “Immobilized Cells And Enzymes” (IRL Press, (1986)); and B. Perbal, “A Practical Guide To Molecular Cloning” (1984)).

[0021] Therefore, if appearing herein, the following terms shall have the definitions set out below.

[0022] A “vector” is a replicon, such as plasmid, phage or cosmid, to which another DNA segment may be attached so as to bring about the replication of the attached segment.

[0023] A “DNA molecule” refers to the polymeric form of deoxyribonucleotides (adenine, guanine, thymine, or cytosine) in either single stranded form, or a double-stranded helix. This term refers only to the primary and secondary structure of the molecule, and does not limit it to any particular tertiary forms. Thus, this term includes double-stranded DNA found, inter alia, in linear DNA molecules (e.g., restriction fragments), viruses, plasmids, and chromosomes.

[0024] As used herein, the term “gene” shall mean a region of DNA encoding a polypeptide chain.

[0025] “Messenger RNA” or “mRNA” shall mean an RNA molecule that encodes for one or more polypeptides.

[0026] “DNA polymerase” shall mean an enzyme which catalyzes the polymerization of deoxyribonucleotide triphosphates to make DNA chains using a DNA template.

[0027] “Reverse transcriptase” shall mean an enzyme which catalyzes the polymerization of deoxy- or ribonucleotide triphosphates to make DNA or RNA chains using an RNA or DNA template.

[0028] “Complementary DNA” or “cDNA” shall mean the DNA molecule synthesized by polymerization of deoxyribonucleotides by an enzyme with reverse transcriptase activity.

[0029] An “isolated nucleic acid” is a nucleic acid the structure of which is not identical to that of any naturally occurring nucleic acid or to that of any fragment of a naturally occurring genomic nucleic acid spanning more than three separate genes. The term therefore covers, for example, (a) a DNA which has the sequence of part of a naturally occurring genomic DNA molecule but is not flanked by both of the coding sequences that flank that part of the molecule in the genome of the organism in which it naturally occurs; (b) a nucleic acid incorporated into a vector or into the genomic DNA of a prokaryote or eukaryote in a manner such that the resulting molecule is not identical to any naturally occurring vector or genomic DNA; (c) a separate molecule such as a cDNA, a genomic fragment, a fragment produced by polymerase chain reaction (PCR), or a restriction fragment; and (d) a recombinant nucleotide sequence that is part of a hybrid gene, i.e., a gene encoding a fusion protein.

[0030] “Oligonucleotide”, as used herein in referring to the probes or primers of the present invention, is defined as a molecule comprised of two or more deoxy- or ribonucleotides, preferably more than ten. Its exact size will depend upon many factors which, in turn, depend upon the ultimate function and use of the oligonucleotide.

[0031] “DNA fragment” includes polynucleotides and/or oligonucleotides and refers to a plurality of joined nucleotide units formed from naturally-occurring bases and cyclofuranosyl groups joined by native phosphodiester bonds. This term effectively refers to naturally-occurring species or synthetic species formed from naturally-occurring subunits. “DNA fragment” also refers to purine and pyrimidine groups and moieties which function similarly but which have non naturally-occurring portions. Thus, DNA fragments may have altered sugar moieties or inter-sugar linkages. Exemplary among these are the phosphorothioate and other sulfur containing species. They may also contain altered base units or other modifications, provided that biological activity is retained. DNA fragments may also include species which include at least some modified base forms. Thus, purines and pyrimidines other than those normally found in nature may be so employed. Similarly, modifications on the cyclofuranose portions of the nucleotide subunits may also occur as long as biological function is not eliminated by such modifications.

[0032] “Primer” shall refer to an oligonucleotide, whether occurring naturally or produced synthetically, which is capable of acting as a point of initiation of synthesis when placed under conditions in which synthesis of a primer extension product, which is complementary to a nucleic acid strand, is induced, i.e., in the presence of nucleotides and an inducing agent such as a DNA polymerase and at a suitable temperature and pH. The primer may be either single-stranded or double-stranded and must be sufficiently long to prime the synthesis of the desired extension product in the presence of the inducing agent. The exact length of the primer will depend upon many factors, including temperature, the source of primer and the method used. For example, for diagnostic applications, depending on the complexity of the target sequence, the oligonucleotide primer typically contains 10-25 or more nucleotides, although it may contain fewer nucleotides.

[0033] The primers herein are selected to be “substantially” complementary to different strands of a particular target DNA sequence. This means that the primers must be sufficiently complementary to hybridize with their respective strands. Therefore, the primer sequence need not reflect the exact sequence of the template. For example, a non-complementary nucleotide fragment may be attached to the 5′ end of the primer, with the remainder of the primer sequence being complementary to the strand. Alternatively, non-complementary bases or longer sequences can be interspersed into the primer, provided that the primer sequence has sufficient complementarity with the sequence or hybridize therewith and thereby form the template for the synthesis of the extension product.

[0034] As used herein, the term “hybridization” refers generally to a technique wherein denatured RNA or DNA is combined with complementary nucleic acid sequence which is either free in solution or bound to a solid phase. As recognized by one skilled in the art, complete complementarity between the two nucleic acid sequences is not a pre-requisite for hybridization to occur. The technique is ubiquitous in molecular genetics and its use centers around the identification of particular DNA or RNA sequences within complex mixtures of nucleic acids.

[0035] As used herein, “restriction endonucleases” and “restriction enzymes” shall refer to bacterial enzymes which cut double-stranded DNA at or near a specific nucleotide sequence.

[0036] “Purified polypeptide” refers to any peptide generated from CA125 either by proteolytic cleavage or chemical cleavage.

[0037] “Degenerate variant” refers to any amino acid variation in the repeat sequence, which fulfills the homology exon structure and conserved sequences and is recognized by the M11, OC125 and ISOBM series of antibodies.

[0038] “Fragment” refers to any part of the CA125 molecule identified in a purification scheme.

[0039] “Conservative variant antibody” shall mean any antibody that fulfills the criteria of M11, OC125 or any of the ISOBM antibody series.

[0040] “Homology” refers to similarity based on identical base matches in alignment. When two sequences are identical there is a 100% homology, as base matches differ in alignment the homology between two sequences is reduced.

[0041] The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The genomic DNA for the CA125 gene is set out in SEQ ID NO: 4. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is assembled by combining five genomic exons, four very short amino terminal sequences and one extraordinarily large exon. This domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. Additionally, an amino terminal extension is present, which comprises four genomic exons. The amino acid composition of the amino terminal extension was found to be consistent with the amino acid composition of the amino terminal domain. The molecular structure is dominated by a repeat domain comprising 156 amino acid repeat units, which encompass the epitope binding sites. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure. The repeat units encompass an interactive disulfide bridged C-enclosure and the site of OC125 and M11 binding. The repeat sequences demonstrated 70-85% homology to each other. Expression of the repeats was demonstrated in E. coli. The CA125 molecule is anchored at its carboxy terminal through a transmembrane domain and a short cytoplasmic tail. The carboxy terminal also contains a proteolytic cleavage site approximately 50 amino acids upstream from the transmembrane domain, which allows for proteolytic cleavage and release of the CA125 molecule. Any one of the repeat domains has the potential for use as a new gold standard for detecting and monitoring the presence of the CA125 antigen. Further, the repeat domains or other domains, especially the c-terminal to the repeat domain also provide a basis for the development of a vaccine, which would be useful for the treatment of ovarian cancer and other carcinomas where CA125 is elevated.

[0042] The DNA sequences of the present invention can also be characterized as encoding the amino acid sequence equivalents of the amino acid sequence, equivalents, as used in this context, include peptides of substantially similar length and amino acid identity to those disclosed, but having conservative amino acid substitution at a non-critical residue position. A conservative amino acid substitution is a substitution in which an amino acid residue is replaced with an amino acid residue of differing identity, but whose R group can be characterized by chemically similar. Four common categories include: polor but uncharged R groups; positively charged R groups; negatively charged R groups; and, hydrophobic R groups. A preferred conservative substitution involves the substitution of a second hydrophobic residue for a fir hydrophobic residue, the first and second hydrophobic residues differing primarily in the size of the R group. The hydrophobic residue would be predicted to be located internally in the folded pepetide structure and the mild pertubatim caused only by a change in the size of an R group at an internally located which would not alter the antigenecity of R protein. More specifically, two nucleic acid molecules are substantially equivalent if they have at least about 70% homology.

[0043] The isolated cDNA sequences (Table 4 and SEQ ID NO: 4) of the present invention can be inserted into an expression vector. Such vectors contain all necessary regulatory signals to promote the expression of a DNA sequence of interest. Expression vectors are typically either prokaryote or eukaryote specific. Expression vectors can be introduced into either prokaryote or eukaryote cells to produce CA125 proteins or portions thereof. The isolated cDNA sequence as shown in Table 4 was expressed to provide the CA125 molecule set out in Table 5 and SEQ ID NO: 5. The expressed CA125 is a polypeptide with the amino acid sequence set forth in SEQ ID NO: 5; an amino acid sequence having at least 50% sequence identity to the sequence, a conservative for variant or a fragment of any of the above. Two polypeptide sequences are substantially equivalent if there is at least 50% sequence homology and substantial similar physical characteristics. However, in practice, a portion of an isolated nucleic acid molecule set out in SEQ ID NO: 4 is expressed to obtain a fragment of the CA125 molecule. This fragment is then purified to obtain an isolated CA125 fragment.

[0044] In certain embodiments, “purified” refers to a polypeptide composition which has been subjected to fractionation to remove various nonprotein components such as other cellular components. Various techniques suitable for use in protein purification are known to those skilled in the relevant art. These techniques include, for example, precipitation with ammonium sulphate, PEG, antibodies and the like or by heat denaturation, followed by centrifugation; chromatography steps such as ion exchange, gel filtration, reverse phase, hydroxylapatite and affinity chromatography; isoelectric focusing; gel electrophoresis; and combination of such techniques. Similarly, a “purification scheme” is a technique or system to remove various nonprotein components such as other cellular components from the expressed protein. Various techniques suitable for use in protein purification are known to those skilled in the relevant art. These techniques include, for example, precipitation with ammonium sulphate, PEG, antibodies and the like or by heat denaturation, followed by centrifugation; chromatography steps such as ion exchange, gel filtration, reverse phase, hydroxylapatite and affinity chromatography; isoelectric focusing; gel electrophoresis; and combination of such techniques.

[0045] The genomic DNA and a full-length cDNA sequence of human CA125 has been determined. Additionally, a nucleic acid molecule encoding a 5′ upstream region of the CA125 gene has been determined. cDNA is expressed with the use of an expression vector. An expression vector is a carrying vector that has an inducer for expression built into the vector. Different vectors use different inducers. The cDNA is ligased into the expression vector using restriction digest sites designed in the vector. The cDNA must be ligased in the sense direction and in the correct reading frame for expression to occur. Once the cDNA is ligased into the expression vector, the construct is transformed into a cell. In the preferred embodiment, we use E-Coli bacteria, but the transformation can be done with yeast, mammalian cells, plants cells, etc. The transformed cells are then grown in culture and protein production is induced with the an inducing agent for the expression vector. In the preferred embodiment, we use the pQE-30 expression vector and induce with IPTG. Once induction has occurred, the cells are harvested and the protein is purified. It should be noted that some expression vectors add tags to the recombinant protein to aid in purification. For example, pQE-30 adds a His—Tag which binds to nickel to aid in purification. Once cells have been successfully transformed, a small aliquot can be frozen and stored for future use.

[0046] With a cDNA sequence, one skilled in the art has an easily renewable source of purified CA125. Portions of this cDNA sequence can be expressed to make CA125 polypeptides and these polypeptides can be used to make monoclonal antibodies. These monoclonal antibodies can be made by one skilled in the art to portions of the protein which heretofore do not have any monoclonal antibodies, such as the amino terminal sequence.

[0047] More specifically, the purified antibodies are made by the following process: the recombinant protein is injected into an animal (usually a mouse, but other animals can be used). The animal's B-lymphocytes produce antibodies to the protein. Each activated B lymphocyte forms a clone of cells in spleen or lymph nodes, with each cell of the clone producing identical antibody. These spleen cells are then harvested and fused with myeloma cells to produce hybridomas. These hybridomas are immortal and produce only one type of antibody. The hybridomas are selected from cells that did not fuse by selective media. The hybidomas can then be grown in large quantities to produce large quantities of monoclonal antibodies.

[0048] Therapeutic Targets: Molecules, which are expressed on the surface of tumor cells as CA125 is, offer potential targets for immune stimulation, drug delivery, biological modifier delivery or any agent which can be specifically delivered to ultimately kill the tumor cells. CA1 25 offers such potential as a target: 1) Antibodies to CA1 25 epitopes or newly described potential epitopes: Most especially humanized or human antibodies to CA125 which could directly activate the patients' immune system to attack and kill tumor cells. Antibodies could be used to deliver all drug or toxic agents including radioactive agents to mediate direct killing of tumor cells. 2) Natural ligands: Under normal circumstances, molecules are bound to the CA125 molecule e.g. a 50 k dalton protein which does not contain CA125 epitopes co-purifies with CA125. Such a molecule, which might have a natural binding affinity for domains on the CA125 molecule, could also be utilized to deliver therapeutic agents to tumor cells.

[0049] Anti-sense therapy: CA125 expression may provide a survival or metastatic advantage to ovarian tumor cells as such antisense oligonucleotide derived from the CA125 sequence could be used to down-regulate the expression of CA125. Antisense therapy could be used in association with a tumor cell delivery system such as described above.

[0050] Small Molecules: Recombinant domains of CA125 also offer the potential to identify small molecules which bind to individual domains of the molecule. Small molecules either from combinatorial chemical libraries or small peptides can also be used as delivery agents or as biological modifiers.

[0051] Transgenic Animals/Transformed: CA125 and genomic DNA can be used to develop transgenic animal models and can be used under low stringency conditions, to clone CA125 cDNAs and genomic DNAs of other animal species. The CA125 cDNA can be used to prepare stable transformants. The bacterial cells could be transformed with CA125 cDNA to include these genes.

EXAMPLE 1

[0052] Expression of 6×His-tagged CA125 repeat in E. coli: The open reading frame of the CA125 repeat was amplified by PCR with the 5′ sense primer 1 (5′-ACCGGATCCATGGGCCACACAGAGCCTGGCCC-3′) (SEQ ID NO: 6) and the 3′ antisense primer 2 (5′-TGTAAGCTTAGGCAGGGAGGATGGAGTCC-3′) (SEQ ID NO: 7). The open reading frame of the CA125 repeat constitutes a portion of the isolated nucleic acid molecule set out in SEQ ID NO: 4. PCR was performed in a reaction mixture consisting of ovarian tumor cDNA derived from 50 ng of mRNA, 5 pmol each of sense and antisense primers for the CA125 repeat, 0.2 mmol of dNTPs, and 0.625 U of Taq polymerase in 1× buffer in a final volume of 25 &mgr;l. This mixture was subjected to 1 minute of denaturation at 95° C. followed by 30 cycles of PCR consisting of the following: denaturation for 30 seconds at 95° C., 30 seconds of annealing at 62° C., and 1 minute of extension at 72° C. with an additional 7 minutes of extension on the last cycle. The product was electrophoresed through a 2% agarose gel for separation, the PCR product was purified and digested with the restriction enzymes BamHI and HindIII. This digested PCR product was ligated into the expression vector pQE-30, which had also been digested with BamHI and HindIII. The ligation reaction consisted of 1 &mgr;l of 10× ligation buffer, 1 &mgr;l of 10× bovine serum albumin (BSA), 1 &mgr;l of T4 ligase enzyme, and 7 &mgr;l of digested PCR product. The reaction went overnight at 15° C. This clone would allow for expression of recombinant amino-terminal 6×His-tagged CA125 repeat. The construct was then transformed into JM109 E. coli cells. The transformation reaction consisted of 5 &mgr;l of ligation reaction and 50 &mgr;l of cells. The reaction was mixed gently and then incubated on ice for 30 minutes. The reaction was then heat shocked at 42° C. for 45 seconds in a water bath before being returned to ice for 2 minutes. 500 &mgr;l of LB broth media were added and the mixture was incubated at 37° C. for 1 hour. At the end of 1 hour the cells were spun down in a microfuge at 4,000×g for 5 minutes and approximately 450 &mgr;l of media was removed. The cells were resuspended in the remaining 100 &mgr;l of media, transferred to a LAIX plate, and incubated overnight at 37° C. White colonies were picked from the plate and cultured in 5 ml LB broth media to determine if the transformation was successful. Transformed E. coli were grown in 1L cultures to an OD600 of 1.5-2.0 at 37° C. and were induced with IPTG (0.1 mM) for 4-6 hours at 25° C. to produce recombinant protein. Whole E. coli lysate was electrophoresed through a denaturing 12% polyacrylamide gel and Coomassie stained to detect highly expressed proteins. His-tagged proteins were purified under denaturing conditions using Ni-NTA agarose metal chelating affinity chromatography available from Qiagen according to the manufacturer's instructions. Cells are spun down to remove liquid LB broth media. The cells are then resuspended in 40 ml of 8M Urea lysis buffer (pH 8.0) and incubated with agitation overnight at room temperature. The mixture is then spun down and the lysate is removed. The lysate is then incubated with Ni-NTA agarose beads with agitation overnight at room temperature. The beads are pelleted and the supernatant is removed. The beads are then washed twice in lysis buffer pH 8.0 plus Triton X, three times with lysis buffer pH 6.3 plus Triton X, and four times with lysis buffer pH 6.3 without Triton X. The protein is then eluted from the beads with lysis buffer pH4.2 plus 25 mM EDTA incubated overnight with agitation at room temperature. The beads are pelleted and the supernatant containing the recombinant protein is removed. The supernatant is then dialyzed twice in 0.2× PBS to remove the urea and freeze dried for storage. 1L of culture produced 2.4 mg of recombinant protein.

[0053] It should be understood that various changes and modifications to the presently preferred embodiments described herein will be apparent to those skilled in the art. Such changes and modifications can be made without departing from the spirit and scope of the present invention and without diminishing its attendant advantages. 1 TABLE 1 Genomic CA125 Amino Terminal Sequence (SEQ ID NO: 1)   1 GGTGCGCACC ACTATGTCTG GCTAATTTTT GTATTTTTTT GTAGAGACAT   51 GGTTTCACCA TGTTGGCCAG GCTGGTCTCG AATTCCTGAC TTCAAGTAAT  101 CCACCCACCT CAGCCTCCCA AAGTGCTGGG ATTACAAGCA TGAGCCACCA  151 TGCATGGCCT AAAGCTTCTT TTAAAGCCAC CAAGTCCCTT CCCATGTTAG  201 CCCACTAATC CATGGGTTAG TCATGAATGG ATTAATCTAT TCATACGGAC  251 AGAGCCCTCA TCACCCAATC ACCTCTTAAA GGCCCCACCT CTCAATACTG  301 CCACACTGGG GATTAAGTTT CAACAGAGTT TTGGAGGGGA CATTCAAATC  351 ATAGTAATGC CCAAAGTGAA AAATCTTCCC TGCACTTTTC CCTCAACAAA  401 AACAGCCAGA GATAGTGAGC TGCCAGGAAA TTCTTTTTTT TTTCCTCTTC  451 TGTCCTAAAT CAGCATCGCT AGACCTTTAC ATGATTCAAC CTCATCTTCT  501 TCACCCTCTG GGTCATGAAA TTTTATTTAT TTATTTATTA TTTTCTTGGG  551 ACAGACTCTG GCTCTGTCGC CCAGGCTGAA GTGCAGTGGT GTGATCTTGG  601 CTCACTGCAA CCTCCGCCTC CCGGGTTCAA GCGATTCTCC TGCCTCAGCC  651 TCCTGAGTAG CTGGGATTAC AGGTGGGCGC CACCACACCC AGCTAATTTT  701 TTGTATTTTT AGTAGAGATG GGGTTTCACC ATATTAGCCA GGATGGTCTC  751 CATCTCTTGA CCTCGTGATC TGCCCACCTC AGCCTCCCAA AATGCTGGGA  801 TTACAGGCAT GAGACACCAC GCCCAGCAGG CCAGGGTCAT GAGATTTTAA  851 TCAAGAGCAA CTTCCACTGA TTCCTGAGAG TGCATCTGTG GGCCCCTGCT  901 CTGATCTGAA CAGAAGTGCC GTGTCTTCTC TGACCTCCAC TTCTCAATTC  951 AAGAGCCTTA GTATCTGCCA GTATCACACA CTGAGCATTA GCTCCATCTC  1001 ATGGGGGTGT AGGTAGGGGC TCTATCTGCA TCTTTCTTTC TTTTTTTCTT  1051 TCTTTCCCTT CCTCCCTTCC TCACTCCCTC GGTCCTCTCT TTCTTTCCTT  1101 TTCTTTCTTC CTTCCTCCCT TCCTCCCTCC CTCCCTCTCT CTTTCTCTCT  1151 TTCTTTCTTT CCTTCTTTCT TTCTTTCTCT CTTCCTTCCC TCCCTCCCTC  1201 CTTCCTTCCT TTCTCTTTCT TTCTCTTTCT TTCTTTTTTT CCTTCCTTCC  1251 TTCCTTCTTT CTCTTTCTCT CCCTCCCTTC CTTCCTTCCT TCCTTCCTTC  1301 CTTCCTTTCT TTCTTTCTTT CTTTCTTTCT TTCTTTCTTT CTTTCTTTCT  1351 TTCTTTCTTC CTTCCTTCCT TCCTTCCTTC CTTCCTTCCT TCCTTCCTTT  1401 CTTTTCTTTC TTTCTCTTTC TTTTTGAGAC AGAGCTCTTA TTACCCATGC  1451 TGGAGTGCAG TGGTGTGACC TTGGCTTACT GCAACATCTG CCTCCTAGGG  1501 TCAAGTGATT CTCCTGCCTC AGCCTCCTAA GTAGCTGGGA TTACAGACAC  1551 ATGCCACCAC ACCCAATATT TATTTTTATT AAAATTTTTT TTAAAATTAT  1601 TTTTAAAAAA TTAAAAATAA TTTTGTATTT TTAGTAGAGA CGGGGTTTCT  1651 CCATGTTGGT CAGGCTGATC TCAAACTCCC AACCTCAGGT GATCCTCCCA  1701 CCTCACCTCC CAAAGTGCTG GGATTACAGG CATGAGCCAC CGTGCCCAGC  1751 CTGGTTCCTG GTTTCTAAGA CATCACACAC ACACACACAC ACACACACAC  1801 ACACTCACAC ACTCAGAGAG AGAGAGAGAG AGAGGATCAT TAAGACATGA  1851 TACACTAAGA AATTCTATTC TGCAGACACT GAGAATCCGT TAAAAAGTTT  1901 GAAGGGAAGA ATTGAGATCA TCAGGTGTTT ATTTGAGGAA ATTGTCTGTG  1951 GTTGAACTAT CCTTTCCTTT CTCTCCCTGA GATTTGGTCT TCTCAATTAG  2001 AAGCGTTGCA CAATTCCCCC AACCTCCATA CATACGGCAG CTCTTCTAGA  2051 CACAGGTTTT CCCAGGTCAA ATGCGGGGAC CCCAGCCATA TCTCCCACCC  2101 TGAGAAATTT TGGAGTTTCA GGGAGCTCAG AAGCTCTGCA GAGGCCACCC  2151 TCTCTGAGGG GATTCTTCTT AGACCTCCAT CCAGAGGCAA ATGTTGACCT Exon 1  2201 GTCCATGCTG AAACCCTCAG GCCTTCCTGG GTCATCTTCT CCCACCCGCT  2251 CCTTGATGAC AGGGAGCAGG AGCACTAAAG CCACACCAGA AATGGATTCA  2301 GGACTGACAG GAGCCACCTT GTCACCTAAG ACATCTACAG GTGCAATCGT  2351 GGTGACAGAA CATACTCTGC CCTTTACTTC CCCAGATAAG ACCTTGGCCA  2401 GTCCTACATC TTCGGTTGTG GGAAGAACCA CCCAGTCTTT GGGGGTGATG  2451 TCCTCTGCTC TCCCTGAGTC AACCTCTAGA GGAATGACAC ACTCCGAGCA  2501 AAGAACCAGC CCATCGCTGA GTCCCCAGGT CAATGGAACT CCCTCTAGGA  2551 ACTACCCTGC TACAAGCATG GTTTCAGGAT TGAGTTCCCC AAGGACCAGG  2601 ACCAGTTCCA CAGAAGGAAA TTTTACCAAA GAAGCATCTA CATACACACT  2651 CACTGTAGAG ACCACAAGTG GCCCAGTCAC TGAGAAGTAC ACAGTCCCCA  2701 CTGAGACCTC AACAACTGAA GGTGACAGCA CAGAGACCCC CTGGGACACA  2751 AGATATATTC CTGTAAAAAT CACATCTCCA ATGAAAACAT TTGCAGATTC  2801 AACTGCATCC AAGGAAAATG CCCCAGTGTC TATGACTCCA GCTGAGACCA  2851 CAGTTACTGA CTCACATACT CCAGGAAGGA CAAACCCATC ATTTGGGACA  2901 CTTTATTCTT CCTTCCTTGA CCTATCACCT AAAGGGACCC CAAATTCCAG  2951 AGGTGAAACA AGCCTGGAAC TGATTCTATC AACCACTGGA TATCCCTTCT  3001 CCTCTCCTGA ACCTGGCTCT GCAGGACACA GCAGAATAAG TACCAGTGCG  3051 CCTTTGTCAT CATCTGCTTC AGTTCTCGAT AATAAAATAT CAGAGACCAG  3101 CATATTCTCA GGCCAGAGTC TCACCTCCCC TCTGTCTCCT GGGGTGCCCG  3151 AGGCCAGAGC CAGCACAATG CCCAACTCAG CTATCCCTTT TTCCATGACA  3201 CTAAGCAATG CAGAAACAAG TGCCGAAAGG GTCAGAAGCA CAATTTCCTC  3251 TCTGGGGACT CCATCAATAT CCACAAAGCA GACAGCAGAG ACTATCCTTA  3301 CCTTCCATGC CTTCGCTGAG ACCATGGATA TACCCAGCAC CCACATAGCC  3351 AAGACTTTGG CTTCAGAATG GTTGGGAAGT CCAGGTACCC TTGGTGGCAC  3401 CAGCACTTCA GCGCTGACAA CCACATCTCC ATCTACCACT TTAGTCTCAG  3451 AGGAGACCAA CACCCATCAC TCCACGAGTG GAAAGGAAAC AGAAGGAACT  3501 TTGAATACAT CTATGACTCC ACTTGAGACC TCTGCTCCTG GAGAAGAGTC  3551 CGAAATGACT GCCACCTTGG TCCCCACTCT AGGTTTTACA ACTCTTGACA  3601 GCAAGATCAG AAGTCCATCT CAGGTCTCTT CATCCCACCC AACAAGAGAG  3651 CTCAGAACCA CAGGCAGCAC CTCTGGGAGG CAGAGTTCCA GCACAGCTGC  3701 CCACGGGAGC TCTGACATCC TGAGGGCAAC CACTTCCAGC ACCTCAAAAG  3751 CATCATCATG GACCAGTGAA AGCACAGCTC AGCAATTTAG TGAACCCCAG  3801 CACACACAGT GGGTGGAGAC AAGTCCTAGC ATGAAAACAG AGAGACCCCC  3851 AGCATCAACC AGTGTGGCAG CCCCTATCAC CACTTCTGTT CCCTCAGTGG  3901 TCTCTGGCTT CACCACCCTG AAGACCAGCT CCACAAAAGG GATTTGGCTT  3951 GAAGAAACAT CTGCAGACAC ACTCATCGGA GAATCCACAG CTGGCCCAAC  4001 CACCCATCAG TTTGCTGTTC CCACTGGGAT TTCAATGACA GGAGGCAGCA  4051 GCACCAGGGG AAGCCAGGGC ACAACCCACC TACTCACCAG AGCCACAGCA  4101 TCATCTGAGA CATCCGCAGA TTTGACTCTG GCCACGAACG GTGTCCCAGT  4151 CTCCGTGTCT CCAGCAGTGA GCAAGACGGC TGCTGGCTCA AGTCCTCCAG  4201 GAGGGACAAA GCCATCATAT ACAATGGTTT CTTCTGTCAT CCCTGAGACA  4251 TCATCTCTAC AGTCCTCAGC TTTCAGGGAA GGAACCAGCC TGGGACTGAC  4301 TCCATTAAAC ACTAGACATC CCTTCTCTTC CCCTGAACCA GACTCTGCAG  4351 GACACACCAA GATAAGCACC AGCATTCCTC TGTTGTCATC TGCTTCAGTT  4401 CTTGAGGATA AAGTGTCAGC GACCAGCACA TTCTCACACC ACAAAGCCAC  4451 CTCATCTATT ACCACAGGGA CTCCTGAAAT CTCAACAAAG ACAAAGCCCA  4501 GCTCAGCCGT TCTTTCCTCC ATGACCCTAA GCAATGCAGC AACAAGTCCT  4551 GAAAGAGTCA GAAATGCAAC TTCCCCTCTG ACTCATCCAT CTCCATCAGG  4601 GGAAGAGACA GCAGGGAGTG TCCTCACTCT CAGCACCTCT GCTGAGACTA  4651 CAGACTCACC TAACATCCAC CCAACTGGGA CACTGACTTC AGAATCGTCA  4701 GAGAGTCCTA GCACTCTCAG CCTCCCAAGT GTCTCTGGAG TCAAAACCAC  4751 ATTTTCTTCA TCTACTCCTT CCACTCATCT ATTTACTAGT GGAGAAGAAA  4801 CAGAGGAAAC TTCGAATCCA TCTGTGTCTC AACCTGAGAC TTCTGTTTCC  4851 AGAGTAAGGA CCACCTTGGC CAGCACCTCT GTCCCTACCC CAGTATTCCC  4901 CACCATGGAC ACCTGGCCTA CACGTTCAGC TCAGTTCTCT TCATCCCACC  4951 TAGTGAGTGA GCTCAGAGCT ACGAGCAGTA CCTCAGTTAC AAACTCAACT  5001 GGTTCAGCTC TTCCTAAAAT ATCTCACCTC ACTGGGACGG CAACAATGTC  5051 ACAGACCAAT AGAGACACGT TTAATGACTC TGCTGCACCC CAAAGCACAA  5101 CTTGGCCAGA GACTAGTCCC AGATTCAAGA CAGGGTTACC TTCAGCAACA  5151 ACCACTGTTT CAACCTCTGC CACTTCTCTC TCTGCTACTG TAATGGTCTC  5201 TAAATTCACT TCTCCAGCAA CTAGTTCCAT GGAAGCAACT TCTATCAGGG  5251 AACCATCAAC AACCATCCTC ACAACAGAGA CCACGAATGG CCCAGGCTCT  5301 ATGGCTGTGG CTTCTACCAA CATCCCAATT GGAAAGGGCT ACATTACTGA  5351 AGGAAGATTG GACACAAGCC ATCTGCCCAT TGGAACCACA GCTTCCTCTG  5401 AGACATCTAT GGATTTTACC ATGGCCAAAG AAAGTGTCTC AATGTCAGTA  5451 TCTCCATCTC AGTCCATGGA TGCTGCTGGC TCAAGCACTC CAGGAAGGAC  5501 AAGCCAATTC GTTGACACAT TTTCTGATGA TGTCTATCAT TTAACATCCA  5551 GAGAAATTAC AATACCTAGA GATGGAACAA GCTCAGCTCT GACTCCACAA  5601 ATGACTGCAA CTCACCCTCC ATCTCCTGAT CCTGGCTCTG CTAGAAGCAC  5651 CTGGCTTGGC ATCTTGTCCT CATCTCCTTC TTCTCCTACT CCCAAAGTCA  5701 CAATGAGCTC CACATTTTCA ACTCAGAGAG TCACCACAAG CATGATAATG  5751 GACACAGTTG AAACTAGTCG GTGGAACATG CCCAACTTAC CTTCCACGAC  5801 TTCCTTGACA CCAAGTAATA TTCCAACAAG TGGTGCCATA GGAAAAAGCA  5851 CCCTGGTTCC CTTGGACACT CCATCTCCAG CCACATCATT GGAGGCATCA  5901 GAAGGGGGAC TTCCAACCCT CAGCACCTAC CCTGAATCAA CAAACACACC  5951 CAGCATCCAC CTCGGAGCAC ACGCTAGTTC AGAAAGTCCA AGCACCATCA  6001 AACTTACCAT GGCTTCAGTA GTAAAACCTG GCTCTTACAC ACCTCTCACC  6051 TTCCCCTCAA TAGAGACCCA CATTCATGTA TCAACAGCCA GAATGGCTTA  6101 CTCTTCTGGG TCTTCACCTG AGATGACAGC TCCTGGAGAG ACTAACACTG  6151 GTAGTACCTG GGACCCCACC ACCTACATCA CCACTACGGA TCCTAAGGAT  6201 ACAAGTTCAG CTCAGGTCTC TACACCCCAC TCAGTGAGGA CACTCAGAAC  6251 CACAGAAAAC CATCCAAAGA CAGAGTCCGC CACCCCAGCT GCTTACTCTG  6301 GAAGTCCTAA AATCTCAAGT TCACCCAATC TCACCAGTCC GGCCACAAAA  6351 GCATGGACCA TCACAGACAC AACTGAACAC TCCACTCAAT TACATTACAC  6401 AAAATTGGCA GAAAAATCAT CTGGATTTGA GACACAGTCA GCTCCAGGAC  6451 CTGTCTCTGT AGTAATCCCT ACCTCCCCTA CCATTGGAAG CAGCACATTG  6501 GAACTAACTT CTGATGTCCC AGGGGAACCC CTGGTCCTTG CTCCCAGTGA  6551 GCAGACCACA ATCACTCTCC CCATGGCAAC ATGGCTGAGT ACCAGTTTGA  6601 CAGAGGAAAT GGCTTCAACA GACCTTGATA TTTCAAGTCC AAGTTCACCC  6651 ATGAGTACAT TTGCTATTTT TCCACCTATG TCCACACCTT CTCATGAACT  6701 TTCAAAGTCA GAGGCAGATA CCAGTGCCAT TAGAAATACA GATTCAACAA  6751 CGTTGGATCA GCACCTAGGA ATCAGGAGTT TGGGCAGAAC TGGGGACTTA  6801 ACAACTGTTC CTATCACCCC ACTGACAACC ACGTGGACCA GTGTGATTGA  6851 ACACTCAACA CAAGCACAGG ACACCCTTTC TGCAACGATG AGTCCTACTC  6901 ACGTGACACA GTCACTCAAA GATCAAACAT CTATACCAGC CTCAGCATCC  6951 CCTTCCCATC TTACTGAAGT CTACCCTGAG CTCGGGACAC AAGGGAGAAG  7001 CTCCTCTGAG GCAACCACTT TTTGGAAACC ATCTACAGAC ACACTGTCCA  7051 GAGAGATTGA GACTGGCCCA ACAAACATTC AATCCACTCC ACCCATGGAC  7101 AACACAACAA CAGGGAGCAG TAGTAGTGGA GTCACCCTGG GCATAGCCCA  7151 CCTTCCCATA GGAACATCCT CCCCAGCTGA GACATCCACA AACATGGCAC  7201 TGGAAAGAAG AAGTTCTACA GCCACTGTCT CTATGGCTGG GACAATGGGA  7251 CTCCTTGTTA CTAGTGCTCC AGGAAGAAGC ATCAGCCAGT CATTAGGAAG  7301 AGTTTCCTCT GTCCTTTCTG AGTCAACTAC TGAAGGAGTC ACAGATTCTA  7351 GTAAGGGAAG CAGCCCAAGG CTGAACACAC AGGGAAATAC AGCTCTCTCC  7401 TCCTCTCTTG AACCCAGCTA TGCTGAAGGA AGCCAGATGA GCACAAGCAT  7451 CCCTCTAACC TCATCTCCTA CAACTCCTGA TGTGGAATTC ATAGGGGGCA  7501 GCACATTTTG GACCAAGGAG GTCACCACAG TTATGACCTC AGACATCTCC  7551 AAGTCTTCAG CAAGGACAGA GTCCAGCTCA GCTACCCTTA TGTCCACAGC  7601 TTTGGGAAGC ACTGAAAATA CAGGAAAAGA AAAACTCAGA ACTGCCTCTA  7651 TGGATCTTCC ATCTCCAACT CCATCAATGG AGGTGACACC ATGGATTTCT  7701 CTCACTCTCA GTAATGCCCC CAATACCACA GATTCACTTG ACCTCAGCCA  7751 TGGGGTGCAC ACCAGCTCTG CAGGGACTTT GGCCACTGAC AGGTCATTGA  7801 ATACTGGTGT CACTAGAGCC TCCAGATTGG AAAACGGCTC TGATACCTCT  7851 TCTAAGTCCC TGTCTATGGG AAACAGCACT CACACTTCCA TGACTTACAC  7901 AGAGAAGAGT GAAGTGTCTT CTTCAATCCA TCCCCGACCT GAGACCTCAG  7951 CTCCTGGAGC AGAGACCACT TTGACTTCCA CTCCTGGAAA CAGGGCCATA  8001 AGCTTAACAT TGCCTTTTTC ATCCATTCCA GTGGAAGAAG TCATTTCTAC  8051 AGGCATAACC TCAGGACCAG ACATCAACTC AGCACCCATG ACACATTCTC  8101 CCATCACCCC ACCAACAATT GTATGGACCA GTACAGGCAC AATTGAACAG  8151 TCCACTCAAC CACTACATGC AGTTTCTTCA GAAAAAGTTT CTGTGCAGAC  8201 ACAGTCAACT CCATATGTCA ACTCTGTGGC AGTGTCTGCT TCCCCTACCC  8251 ATGAGAATTC AGTCTCTTCT GGAAGCAGCA CATCCTCTCC ATATTCCTCA  8301 GCCTCACTTG AATCCTTGGA TTCCACAATC AGTAGGAGGA ATGCAATCAC  8351 TTCCTGGCTA TGGGACCTCA CTACATCTCT CCCCACTACA ACTTGGCCAA  8401 GTACTAGTTT ATCTGAGGCA CTGTCCTCAG GCCATTCTGG GGTTTCAAAC  8451 CCAAGTTCAA CTACGACTGA ATTTCCACTC TTTTCAGCTG CATCCACATC  8501 TGCTGCTAAG CAAAGAAATC CAGAAACAGA GACCCATGGT CCCCAGAATA  8551 CAGCCGCGAG TACTTTGAAC ACTGATGCAT CCTCGGTCAC AGGTCTTTCT  8601 GAGACTCCTG TGGGGGCAAG TATCAGCTCT GAAGTCCCTC TTCCAATGGC  8651 CATAACTTCT AGATCAGATG TTTCTGGCCT TACATCTGAG AGTACTGCTA  8701 ACCCGAGTTT AGGCACAGCC TCTTCAGCAG GGACCAAATT AACTAGGACA  8751 ATATCCCTGC CCACTTCAGA GTCTTTGGTT TCCTTTAGAA TGAACAAGGA  8801 TCCATGGACA GTGTCAATCC CTTTGGGGTC CCATCCAACT ACTAATACAG  8851 AAACAAGCAT CCCAGTAAAC AGCGCAGGTC CACCTGGCTT GTCCACAGTA  8901 GCATCAGATG TAATTGACAC ACCTTCAGAT GGGGCTGAGA GTATTCCCAC  8951 TGTCTCCTTT TCCCCCTCCC CTGATACTGA AGTGACAACT ATCTCACATT  9001 TCCCAGAAAA GACAACTCAT TCATTTAGAA CCATTTCATC TCTCACTCAT  9051 GAGTTGACTT CAAGAGTGAC ACCTATTCCT GGGGATTGGA TGAGTTCAGC  9101 TATGTCTACA AAGCCCACAG GAGCCAGTCC CTCCATTACA CTGGGAGAGA  9151 GAAGGACAAT CACCTCTGCT GCTCCAACCA CTTCCCCCAT AGTTCTCACT  9201 GCTAGTTTCA CAGAGACCAG CACAGTTTCA CTGGATAATG AAACTACAGT  9251 AAAAACCTCA GATATCCTTG ACGCACGGAA AACAAATGAG CTCCCCTCAG  9301 ATAGCAGTTC TTCTTCTGAT CTGATCAACA CCTCCATAGC TTCTTCAACT  9351 ATGGATGTCA CTAAAACAGC CTCCATCAGT CCCACTAGCA TCTCAGGAAT  9401 GACAGCAAGT TCCTCCCCAT CTCTCTTCTC TTCAGATAGA CCCCAGGTTC  9451 CCACATCTAC AACAGAGACA AATACAGCCA CCTCTCCATC TGTTTCCAGT  9501 AACACCTATT CTCTTGATGG GGGCTCCAAT GTGGGTGGCA CTCCATCCAC  9551 TTTACCACCC TTTACAATCA CCCACCCTGT CGAGACAAGC TCGGCCCTAT  9601 TAGCCTGGTC TAGACCAGTA AGAACTTTCA GCACCATGGT CAGCACTGAC  9651 ACTGCCTCCG GAGAAAATCC TACCTCTAGC AATTCTGTGG TGACTTCTGT  9701 TCCAGCACCA GGTACATGGA CCAGTGTAGG CAGTACTACT GACTTACCTG  9751 CCATGGGCTT TCTCAAGACA AGTCCTGCAG GAGAGGCACA CTCACTTCTA  9801 GCATCAACTA TTGAACCAGC CACTGCCTTC ACTCCCCATC TCTCAGCAGC  9851 AGTGGTCACT GGATCCAGTG CTACATCAGA AGCCAGTCTT CTCACTACGA  9901 GTGAAAGCAA AGCCATTCAT TCTTCACCAC AGACCCCAAC TACACCCACC  9951 TCTGGAGCAA ACTGGGAAAC TTCAGCTACT CCTGAGAGCC TTTTGGTAGT 10001 CACTGAGACT TCAGACACAA CACTTACCTC AAAGATTTTG GTCACAGATA 10051 CCATCTTGTT TTCAACTGTG TCCACGCCAC CTTCTAAATT TCCAAGTACG 10101 GGGACTCTGT CTGGAGCTTC CTTCCCTACT TTACTCCCGG ACACTCCAGC 10151 CATCCCTCTC ACTGCCACTG AGCCAACAAG TTCATTAGCT ACATCCTTTG 10201 ATTCCACCCC ACTGGTGACT ATAGCTTCGG ATAGTCTTGG CACAGTCCCA 10251 GAGACTACCC TGACCATGTC AGAGACCTCA AATGGTGATG CACTGGTTCT 10301 TAAGACAGTA AGTAACCCAG ATAGGAGCAT CCCTGGAATC ACTATCCAAG 10351 GAGTAACAGA AAGTCCACTC CATCCTTCTT CCACTTCCCC CTCTAAGATT 10401 GTTGCTCCAC GGAATACAAC CTATGAAGGT TCGATCACAG TGGCACTTTC 10451 TACTTTGCCT GCGGGAACTA CTGGTTCCCT TGTATTCAGT CAGAGTTCTG 10501 AAAACTCAGA GACAACGGCT TTGGTAGACT CATCAGCTGG GCTTGAGAGG 10551 GCATCTGTGA TGCCACTAAC CACAGGAAGC CAGGGTATGG CTAGCTCTGG 10601 AGGAATCAGA AGTGGGTCCA CTCACTCAAC TGGAACCAAA ACATTTTCTT 10651 CTCTCCCTCT GACCATGAAC CCAGGTGAGG TTACAGCCAT GTCTGAAATC 10701 ACCACGAACA GACTGACAGC TACTCAATCA ACAGCACCCA AAGGGATACC 10751 TGTGAAGCCC ACCAGTGCTG AGTCAGGCCT CCTAACACCT GTCTCTGCCT 10801 CCTCAAGCCC ATCAAAGGCC TTTGCCTCAC TGACTACAGC TCCCCCAACT 10851 TGGGGGATCC CACAGTCTAC CTTGACATTT GAGTTTTCTG AGGTCCCAAG 10901 TTTGGATACT AAGTCCGCTT CTTTACCAAC TCCTGGACAG TCCCTGAACA 10951 CCATTCCAGA CTCAGATGCA AGCACAGCAT CTTCCTCACT GTCCAAGTCT 11001 CCAGAAAAAA ACCCAAGGGC AAGGATGATG ACTTCCACAA AGGCCATAAG 11051 TGCAAGCTCA TTTCAATCAA CAGGTTTTAC TGAAACCCCT GAGGGATCTG 11101 CCTCCCCTTC TATGGCAGGG CATGAACCCA GAGTCCCCAC TTCAGGAACA 11151 GGGGACCCTA GATATGCCTC AGAGAGCATG TCTTATCCAG ACCCAAGCAA 11201 GGCATCATCA GCTATGACAT CGACCTCTCT TGCATCAAAA CTCACAACTC 11251 TCTTCAGCAC AGGTCAAGCA GCAAGGTCTG GTTCTAGTTC CTCTCCCATA 11301 AGCCTATCCA CTGAGAAAGA AACAAGCTTC CTTTCCCCCA CTGCATCCAC 11351 CTCCAGAPAG ACTTCACTAT TTCTTGGGCC TTCCATGGCA AGGCAGCCCA 11401 ACATATTGGT GCATCTTCAG ACTTCAGCTC TGACACTTTC TCCAACATCC 11451 ACTCTAAATA TGTCCCAGGA GGAGCCTCCT GAGTTAACCT CAAGCCAGAC 11501 CATTGCAGAA GAAGAGGGAA CAACAGCTGA AACACAGACG TTAACCTTCA 11551 CACCATCTGA GACCCCAACA TCCTTGTTAC CTGTCTCTTC TCCCACAGAA 11601 CCCACAGCCA GAAGAAAGAG TTCTCCAGAA ACATGGGCAA GCTCTATTTC 11651 AGTTCCTGCC AAGACCTCCT TGGTTGAAAG TAAGAATGCC CTGCTCCTTC 11701 CCCAAGTGTG CTGGGGATGA ATCTGGAAAT AAACTACATC TTTTTTATTT 11751 TTTAAACTTT TATATTTGAA AATATAAATA TTTTAGGTTC AGGGAACATG 11801 TGCAGGTTTG TTATATAGGT AAATTGCATG TCATGGGGGC TTGGGGTACA 11851 GATTACATCA TCAGCCAGGT AATAAGCCTA GTACCTGATC AGTAGATTTT 11901 TTTTAATCCT CTCCCTCCTC CCAGCCTCCA CCCTCAATTC ACATGTCTCC 11951 ATGTGTACTC AAGGTTTAAT TCCCACTTAT GAGTGAGAAC ATGCGGTATT 12001 TGTAAACTAC ATCTTTATTT TTGCTAACCT CGAACTGAAA TTTAGCATTT 12051 GTTTTATTGA TGAATAGAGG TAACAAAACA AACCACATTA ATCCTAGCAG 12101 TGCCTGTGCC TTTGCCAACA ACAGAAATTC CGGACACTTT CATATCCTAT 12151 GACAATTGTT GCAAGCACTT TTAAAAATCA TGTACGACTT TATTCATAAT 12201 TATAGTGGTT ATTAGGCTTT TCAATAGATC TTATTTAATG AGTTAGTAAA 12251 ATAAGTGCCT GTATTATTGT ATTACATTTG TTTATTAAGA TCTTGATAAC 12301 AACATTTCAA TATAATCATT TCCTTTGTTT TTTAAATTTT AGATTCAGGG 12351 GTATATGTGC AGGTTTGTTA CGTGGATATA CTGCATAATG ATGAGGTTTG 12401 GCTTCTAGTG AACCCATCAG CCAAATAGTG AATGTTGTGC CCAATAAGTA 12451 GTTTTTCAAT CCTCACTTCA CTCCCAGCCT CCTCTATTTT GGAGTCCCAG 12501 TGTCTATTAT TTCTATCTTT ATGTCCACAT GTACCCATTG GTTAGCTCCC 12551 ACTTATAAGT GAGAATGTGC AGTATTTAAT TTTCTGTTTT TGAGTTATTT 12601 TGCTTAGGTT GATGGCCTTC AGCTCCAGCC ACGTTGCTTT AAAGAACATG 12651 ATTTCATTCT TTTTTATGGC TGCATAGTAC TCCGAGGTGT ATGTGTACCA 12701 GATTTTCTTT ATCCACAATG ATTTCCTTTG TAATCTAATA TTTTATATTG 12751 TTATTTTATG TTTTATTCTA TATTTTTATT TTAATTTATA AAGGAATTCA 12801 TATGGTTCAC AAGCCTGTCA AAGGGACCTA TAATAAAAAG AGGTTAAGAA 12851 TCCATGCTCT AAACAGAATA TTACTCCATT TTATTTCATT TATTTTTAAA 12901 GAGACAGTCT CACTCTGTCA TCCAGGCTGG AGTACAGTGG AGTGATCATA 12951 GCTCATTGCA ACCCTGAACT CTTGGGCACA AGCAATTCTC CTGCTTCATC 13001 CTCCAGAGGA GCTGGGACTA CAGGTGCACA TCACCATGCC CAGCTAGTTT 13051 TAAAAATTAT TTTGTAGAGA TGGTGTCTCA CTATCCTACC CAGGCTGGTC 13101 TCAAACTCCT GGGCTCAGGC AATCCTCCCA CTTTGACCTC CCAAAGTGTT 13151 GAGATTACAG GGGCAAGCCA CTGTGCCTGG CCACTTGTCA CATTTTAATT 13201 TGTGATTACT TATAAAATGA ACCCCTTCCC ATCTGAGATC TGTCAGTCTT 13251 TCTGGTGACG GTGCCTGGTG TCTGCTTTCT ACCATGTCCT GTTAGACTAG 13301 TGTTTGATGG GAGGTCACCT GGGCAGCTGT CCAGCTCACT CACTGGGCTC 13351 TAGAGCCTCT GAGTTGAAGC AAAATAGAAA GATCAGTCAA TGTAAAGAAA 13401 GCTCAAAAAC TGACATTCTG AAGTAATGGA TAGCTAAACC TTCCTATTGC Exon 2 13451 CCTTTTCTTT CAGCAACTGA TGGAACGCTA GTGACCACCA TAAAGATGTC 13501 AAGCCAGGCA GCACAAGGAA ATTCCACGTG GCCTGCCCCA GCAGAGGAGA 13551 CGGGGACCAG TCCAGCAGGT AAATATAGAC CTTGTTTCCA TTTCTGCTCT 13601 GCTAATGCCA CCCAAGCCTT TCTTTTCTTT TCTTTTCTTT TCTTTTCTTT 13651 TCTTTTCTTT TCTTTTCTTT CTCTCCCTTT CTTTCTTTCT TTCTTTCTTT 13701 CTTTCTTTCT TTCTTTCTTT CTTTCTTTCT CTTTCTTTCT TTCTTTCTTT 13751 CTTTCTTTCT TTCTTTCTTT CTTTCTTTCT CTTTCTTTCT TCTTTCTCTC 13801 TCTCTCTTTC TTTCTTTCTC TTGTTCTTTT TAAATTTTTT ATTTTTTTAC 13851 TTAATTTTTT TCACCCAAGC CTTAAGGCCA GTTTGGACCA GATAGTGAGA 13901 CCCCACCTCT ATAAAAAAAA TTTTTAAAAA AAAAATAAGT TGGGCATCGT 13951 GCAGGCCTGT AGTCCCTGCT ACTCGAGAGG CCAAGGTGGG AGGACAGCTT 14001 GCTGCTGACT AAAAGTGCTG CTTATTGATT CTGGGAAGAA AAAATATACA 14051 AGGCTTCAGT TTCATTATTT TATAAGTAAA TGCTAGCAAC TTTTCCTTTC 14101 TTTCTCTCTT TCTCTCTTCC TCTCTTTCTC TCCTCTCCTT CTCTTCTCTC 14151 TCTCTCTCTC TCTCTCTCTC TTTCTCTCTC CTCTCCTTCT CTTCTCTTCT 14201 TTCTCTCTCT CTCTCTTTCA TTTATTTTTG AGACATGGTC TCATTCTGTC 14251 ACCCAGGCTG GAGTACAGTG GTGTATATTT ACTGCAGTAC TCACTGTACT 14301 CACTGCAGCC TCAAATTCCT GGGCTCAAGC TATCCTCTCA CCTCAGCCTC 14351 CTGAGTAGCT GGGCAGCAGT CCAGCTCACT CACTGGGCTC TAGAGCCTCT 14401 GTGCTATGCC CAGCTTATTG TTGTTGTTTT TTTAAATTTT TTTTTTTGTA 14451 CAGATGGGGT CTCACTATGT GGCCCAAGGT GGTCTTAAAC TCCTGGCTCC 14501 AAGAGATCCT CCCACCTCAG CCTCCCAAAG TGCAGGGATT ACAGGTGTGA 14551 GCCACTGTGC CCAGCCTAGA CAGCATTTTT TTTTTTTGAA ACAGGGTCTC 14601 CCTCTGTTGC CCAGGCTGGA GTGCAATGGC GTGTTCATGG TTCACTGCAG 14651 CCTCAGCCTC CTCAGTCTCA AGCAATCCTC CAACTTCAGC CTCCCCCAAC 14701 AGCTAGAACT GCAGGTGATC ATCACCAATT AGCCTGGTTA ATTGTGTGTG 14751 TATTTCTTAA ATTTTTTGTA GAGATAGTTC TCACTATATT GCTTGGGCTG 14801 GTCTCAAACT CCTGGACTCA AGTGATTCAC CTACCTCGGC CTCCCTAAGC 14851 ACTGGGATTA CAGGCTTGAG CCACCACACC CGGCAAGGAC TAGGTTTTAA 14901 AATAGGTTCC TAGGCTGGGT GTGGTGGCTT ACGCCCGTAA TCCCAGCACT 14951 TTGGGAGGCT GAGGTGGGCG GATCACGAGG TCAGGAGTTT GAGACCAGCC 15001 TGGCCAACAT AGTGAAACCC TGTCTCTACT AAAAATACAA AAAATTAGCT 15051 GGGCATAGTG GCACACACCT GTAATCCCAG CTACTCGGGA GGCTGAGGAA 15101 GGAGAATCAC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCAT 15151 GCCATTGCTC TCCAGCCTGG GTGACAGAGC AAGACTCCAT CTAAAAAAAA 15201 AAAAAAAAGT TCCTTTGACT TCTTGACACT CTTCTCTGAG GATATTGATC 15251 ATTTTTCCCC AATAGATGTT ACTAATTGAA CACTTCTGTT GCTTCAACTT 15301 ACTAATTTAC ATGATCAATA GCCAATTAAT TCAGCAGGAG AGAATGCTAC 15351 AGAGTCGATT CTTTCTGTAC TTTCTTCTGC TCCAGAGTGA AGGATCTTTC 15401 TAAATCAGAG ACCATCACTG TGTTCACAGG GAGGGCCTAG GTGAACCTGA 15451 GATGGCAAAT GTTGCGTTTG TTCTACGGAA GAAGGGATTA TGGGTTGAAG 15501 TCCTTGGCAG TGCCAAATTG CTTAGAAAAA TGTGAAATAT GGTCCCTAGG 15551 AGTGCTCTTG GGATGTCACA TTTTTCTCAC TCCTTTGACA GGTAGATGTT 15601 ATTTTCCTGA AGGCCAGGGA AAGGATTCAG AGGGAGGAAT GAATTTGAAA 15651 GAAAATGAAG GTGACGAGAA AGAATGAGCT CATCTCCCTT ATCCTCTTTC 15701 TTCTCAAATC CTTAAGTAGC TTTGCAGTGA ACTAAGATTT GGGGGAACCT 15751 AGAGGAGGCT GAAAGTTGGA AGCTGAAATT GGCTTAGCAA GGGCAAGCTC 15801 CAAAGACAAA AGTGGAAATA GTTTGGGGGT AGCCTTTTGC ATGGGTGAAA 15851 TCCTGGTTCA TCACATCCTC CCTTATGCAA AGAGCCCTTT TATATGGGGC 15901 ATGGGGAAAA ACTGAGCTAA AGGTGATAAT TTCTCCTGAG CAAGCCAGAT 15951 GGTCAAAGCT CTAACTTCAC CATCTCCCTT GGAATGTTTA ATGTGTTCCC 16001 TGGTGTCCAG AGGCTTAACG TGTGAGAATT AAAAGCTCAA CATTTTCTTT 16051 CCCAGGGAAG GAGGAAATAG TTTTAATTGA AATCCCGGGA GGAAATGAAT 16101 GATAGTGTCA AACCAAAAAA CTTCATCTTC TGTACCACTT GCATATACTC Exon 3 16151 CACTGACTTA CTTTCTAATC ACAGGCACAT CCCCAGGAAG CCCAGAAATG 16201 TCTACCACTC TCAAAATCAT GAGCTCCAAG GAACCCGGCA TCAGCCCAGA 16251 GATCAGGTCC ACTGTGAGAA ATTCTCCTTG GAAGACTCCA GAAACAACTG 16301 TTCCCATGGA GACCACAGTG GAACCAGTCA CCCTTCAGTC CACAGCCCTA 16351 GGAAGTGGCA GCACCAGCAT CTCTCACCTG CCCACAGGAA CCACATCACC 16401 AACCAAGTCA CCAACAGAAA ATATGTTGGC TACAGAAAGG GTCTCCCTCT 16451 CCCCATCCCC ACCTGAGGCT TGGACCAACC TTTATTCTGG AACTCCAGGA 16501 GGGACCAGGC AGTCACTGGC CACAATGTCC TCTGTCTCCC TAGAGTCACC 16551 AACTGCTAGA AGCATCACAG GGACTGGTCA GCAAAGCAGT CCAGAACTGG 16601 TTTTAAAGAC AACTGGAATG GAATTCTCTA TGTGGCATGG CTCTACTGGA 16651 GGGACCACAG GGGACACACA TGTCTCTCTG AGCACATCTT CCAATATCCT 16701 TGAAGACCCT GTAACCAGCC CAAACTCTGT GAGCTCATTG ACAGATAAAT 16751 CCAAACATAA AACCGAGACA TGGGTCAGCA CCACAGCCAT TCCCTCCACT 16801 GTCCTGAATA ATAAGATAAT GGCAGCTGAA CAACAGACAA GTCGATCTGT 16851 GGATGAGGCT TATTCATCAA CTAGTTCTTG GTCAGATCAG ACATCTGGGA 16901 GTGACATCAC CCTTGGTGCA TCTCCTGATG TCACAAACAC ATTATACATC 16951 ACCTCCACAG CACAAACCAC CTCACTAGTA TCTCTGCCCT CTGGAGACCA 17001 AGGCATTACA AGCCTCACCA ATCCCTCAGG AGGAAAAACA AGCTCTGCAT 17051 CATCTGTCAC ATCTCCTTCA ATAGGGCTTG AGACTCTGAT GGCCAATGTA 17101 AGTGCAGTGA CAAGTGACAT TGCCCCTACT GCTGGGCATC TATCTCAGAC 17151 TTCATCTCCT GCGGAAGTGA GCATCCTGGA CATAACCACA GCTCCTACTC 17201 CAGGTATCTC CACCACCATC ACCACCATGG GAACCAACTC AATCTCAACT 17251 ACCACACCCA ACCCAGAAGT GGGTATGAGT ACCATGGACA GCACCCCGGC 17301 CACAGAGAGG CACACAACTT CTACAGAACA CCCTTCCACC TGGTCTTCCA 17351 CAGCTGCATC AGATTCCTGG ACTGTCACAG ACATGACTTC AAACTTGAAA 17401 GTTGCAAGAT CTCCTGGAAC AATTTCCACA ATGCATACAA CTTCATTCTT 17451 AGCCTCAAGC ACTGAATTAG ACTCCATGTC TACTCCCCAT GGCCGTATAA 17501 CTGTCATTGG AACCAGCCTG GTCACTCCAT CCTCTGATGC TTCAGCTGTA 17551 AAGACAGAGA CCAGTACAAG TGAAAGAACA TTGAGTCCTT CAGACACAAC 17601 TGCATCTACT CCCATCTCAA CTTTTTCTCG TGTCCAGAGG ATGAGCATCT 17651 CAGTTCCTGA CATTTTAAGT ACAAGTTGGA CTCCCAGTAG TACAGAAGCA 17701 GAAGATGTGC CTGTTTCAAT GGTTTCTACA GATCATGCTA GTACAAAGAC 17751 TGACCCAAAT ATGCCCCTGT CCACTTTTCT GTTTGATTCT CTGTCCACTC 17801 TTGACTGGGA CACTGGGAGA TCTCTGTCAT CAGCCACAGC CACTACCTCA 17851 GCTCCTCAGG GGGCCACAAC TCCCCAAGAA CTCACTTTGG AAACCATGAT 17901 CAGCCCAGCT ACCTCACAGT TGCCCTTCTC TATAGGGCAC ATTACAAGTG 17951 CAGTCATACC AGCTGCAATG GCAAGGAGCT CTGGAGTTAC TTTTTCAAGA 18001 CCAGATCCCA CAAGCAAAAA GGCAGAGCAG ACTTCCACTC AGCTTCCCAC 18051 CACCACTTCT GCACATCCAG AGCAGGTGCC CAGATCAGCA GCAACAACTC 18101 TGGATGTGAT CCCACACACA GCAAAAACTC CAGATGCAAC TTTTCAGAGA 18151 CAAGGGCAGA CAGCTCTTAC AACAGAGGCA AGAGCTACAT CTGACTCCTG 18201 GAATGAGAAA GAAAAATCAA CCCCAAGTGC ACCTTGGATC ACTGAGATGA 18251 TGAATTCTGT CTCAGAAGAT ACCATCAAGG AGGTTACCAG CTCCTCCAGT 18301 GTGTTAAGGA CCCTGAATAC GCTGGACATA AACTTGGAAT CTGGGACGAC 18351 TTCATCCCCA AGTTGGAAAA GCAGCCCATA TGAGAGAATT GCCCCTTCTG 18401 AGTCTACCAC AGACAAAGAG GCAATTCACC CTTCTACAAA CACAGTAGAG 18451 ACCACTGGCT GGGTCACAAG TTCCGAACAT GCTTCTCATT CCACTATCCC 18501 AGCCCACTCA GCGTCATCCA AACTCACATC TCCAGTGGTT ACAACCTCCA 18551 CCAGGGAACA AGCAATAGTT TCTATGTCAA CAACCACATG GCCAGAGTCT 18601 ACAAGGGCTA GAACAGAGCC TAATTCCTTC TTGACTATTG AACTGAGGGA 18651 CGTCAGCCCT TACATGGACA CCAGCTCAAC CACACAAACA AGTTTTATCT 18701 CTTCCCCAGG TTCCACTGCG ATCACCAAGG GGCCTAGAAC AGAAATTACC 18751 TCCTCTAAGA GAATATCCAG CTCATTCCTT GCCCAGTCTA TGAGGTCGTC 18801 AGACAGCCCC TCAGAAGCCA TCTCCAGGCT GTCTAACTTT CCTGCCATGA 18851 CAGAATCTGG AGGAATGATC CTTGCTATGC AAACAAGTCC ACCTGGCGCT 18901 ACATCACTAA GTGCACCTAC TTTGGATACA TCAGCCACAG CCTCCTGGAC 18951 AGGGACTCCA CTGGCTACGA CTCAGAGATT TACATACTCA GAGAAGACCA 19001 CTCTCTTTAG CAAAGGTCCT GAGGATACAT CACAGCCAAG CCCTCCCTCT 19051 GTGGAAGAAA CCAGCTCTTC CTCTTCCCTG GTACCTATCA ATGCTACAAC 19101 CTCGCCTTCC AATATTTTGT TGACATCACA AGGGCACAGT CCCTCCTCTA 19151 CTCCACCTGT GACCTCAGTT TTCTTGTCTG AGACCTCTGG CCTGGGGAAG 19201 ACCACAGACA TGTCGAGGAT AAGCTTGGAA CCTGGCACAA GTTTACCTCC 19251 CAATTTGAGC AGTACAGCAG GTGAGGCGTT ATCCACTTAT GAAGCCTCCA 19301 GAGATACAAA GGCAATTCAT CATTCTGCAG ACACAGCAGT GACGAATATG 19351 GAGGCAACCA GTTCTGAATA TTCTCCTATC CCAGGCCATA CAAAGCCATC 19401 CAAAGCCACA TCTCCATTGG TTACCTCCCA CATCATGGGG GACATCACTT 19451 CTTCCACATC AGTATTTGGC TCCTCCGAGA CCACAGAGAT TGAGACAGTG 19501 TCCTCTGTGA ACCAGGGACT TCAGGAGAGA AGCACATCCC AGGTGGCCAG 19551 CTCTGCTACA GAGACAAGCA CTGTCATTAC CCATGTGTCT AGTGGTGATG 19601 CTACTACTCA TGTCACCAAG ACACAAGCCA CTTTCTCTAG CGGAACATCC 19651 ATCTCAAGCC CTCATCAGTT TATAACTTCT ACCAACACAT TTACAGATGT 19701 GAGCACCAAC CCCTCCACCT CTCTGATAAT GACAGAATCT TCAGGAGTGA 19751 CCATCACCAC CCAAACAGGT CCTACTGGAG CTGCAACACA GGGTCCATAT 19801 CTCTTGGACA CATCAACCAT GCCTTACTTG ACAGAGACTC CATTAGCTGT 19851 GACTCCAGAT TTTATGCAAT CAGAGAAGAC CACTCTCATA AGCAAAGGTC 19901 CCAAGGATGT GTCCTGGACA AGCCCTCCCT CTGTGGCAGA AACCAGCTAT 19951 CCCTCTTCCC TGACACCTTT CTTGGTCACA ACCATACCTC CTGCCACTTC 20001 CACGTTACAA GGGCAACATA CATCCTCTCC TGTTTCTGCG ACTTCAGTTC 20051 TTACCTCTGG ACTGGTGAAG ACCACAGATA TGTTGAACAC AAGCATGGAA 20101 CCTGTGACCA ATTCACCTCA AAATTTGAAC AATCCATCAA ATGAGATACT 20151 GGCCACTTTG GCAGCCACCA CAGATATAGA GACTATTCAT CCTTCCATAA 20201 ACAAAGCAGT GACCAATATG GGGACTGCCA GTTCAGCACA TGTACTGCAT 20251 TCCACTCTCC CAGTCAGCTC AGAACCATCT ACAGCCACAT CTCCAATGGT 20301 TCCTGCCTCC AGCATGGGGG ACGCTCTTGC TTCTATATCA ATACCTGGTT 20351 CTGAGACCAC AGACATTGAG GGAGAGCCAA CATCCTCCCT GACTGCTGGA 20401 CGAAAAGAGA ACAGCACCCT CCAGGAGATG AACTCAACTA CAGAGTCAAA 20451 CATCATCCTC TCCAATGTGT CTGTGGGGGC TATTACTGAA GCCACAAAAA 20501 TGGAAGTCCC CTCTTTTGAT GCAACATTCA TACCAACTCC TGCTCAGTCA 20551 ACAAAGTTCC CAGATATTTT CTCAGTAGCC AGCAGTAGAC TTTCAAACTC 20601 TCCTCCCATG ACAATATCTA CCCACATGAC CACCACCCAG ACAGGGTCTT 20651 CTGGAGCTAC ATCAAAGATT CCACTTGCCT TAGACACATC AACCTTGGAA 20701 ACCTCAGCAG GGACTCCATC AGTGGTGACT GAGGGGTTTG CCCACTCAAA 20751 AATAACCACT GCAATGAACA ATGATGTCAA GGACGTGTCA CAGACAAACC 20801 CTCCCTTTCA GGATGAAGCC AGCTCTCCCT CTTCTCAAGC ACCTGTCCTT 20851 GTCACAACCT TACCTTCTTC TGTTGCTTTC ACACCGCAAT GGCACAGTAC 20901 CTCCTCTCCT GTTTCTATGT CCTCAGTTCT TACTTCTTCA CTGGTAAAGA 20951 CCGCAGGCAA GGTGGATACA AGCTTAGAAA CAGTGACCAG TTCACCTCAA 21051 AGATATAGAG ACAACGCATC CTTCCATAAA CACAGTAGTT ACCAATGTGG 21101 GGACCACCGG TTCAGCATTT GAATCACATT CTACTGTCTC AGCTTACCCA 21151 GAGCCATCTA AAGTCACATC TCCAAATGTT ACCACCTCCA CCATGGAAGA 21201 CACCACAATT TCCAGATCAA TACCTAAATC CTCTAAGACT ACAAGAACTG 21251 AGACTGAGAC AACTTCCTCC CTGACTCCTA AACTGAGGGA GACCAGCGTC 21301 TCCCAGGAGA TCACCTCGTC CACAGAGACA AGCACTGTTC CTTACAAAGA 21351 GCTCACTGGT GCCACTACCG AGGTATCCAG GACAGATGTC ACTTCCTCTA 21401 GCAGTACATC CTTCCCTGGC CCTGATCAGT CCACAGTGTC ACTAGACATC 21451 TCCACAGAAA CCAACACCAG GCTGTCTACC TCCCCAATAA TGACAGAATC 21501 TGCAGAAATA ACCATCACCA CCCAAACAGG TCCTCATGGG GCTACATCAC 21551 AGGATACTTT TACCATGGAC CCATCAAATA CAACCCCCCA GGCAGGGATC 21601 CACTCAGCTA TGACTCATGG ATTTTCACAA TTGGATGTGA CCACTCTTAT 21651 GAGCAGAATT CCACAGGATG TATCATGGAC AAGTCCTCCC TCTGTGGATA 21701 AAACCAGCTC CCCCTCTTCC TTTCTGCCCT CACCTGCAAT GACCACACCT 21751 TCCCTGATTT CTTCTACCTT ACCAGAGGAT AAGCTCTCCT CTCCTATGAC 21801 TTCACTTCTC ACCTCTGGCC TAGTGAAGAT TACAGACATA TTACGTACAC 21851 GCTTGGAACC TGTGACCAGC TCACTTCCAA ATTTCAGCAG CACCTCAGAT 21901 AAGATACTGG CCACTTCTAA AGACAGTAAA GACACAAAGG AAATTTTTCC 21951 TTCTATAAAC ACAGAAGAGA CCAATGTGAA AGCCAACAAC TCTGGACATG 22001 AATCCCATTC CCCTGCACTG GCTGACTCAG AGACACCCAA AGCCACAACT 22051 CAAATGGTTA TCACCACCAC TGTGGGAGAT CCAGCTCCTT CCACATCAAT 22101 GCCAGTGCAT GGTTCCTCTG AGACTACAAA CATTAAGAGA GAGCCAACAT 22151 ATTTCTTGAC TCCTAGACTG AGAGAGACCA GTACCTCTCA GGAGTCCAGC 22201 TTTCCCACGG ACACAAGTTT TCTACTTTCC AAAGTCCCCA CTGGTACTAT 22251 TACTGAGGTC TCCAGTACAG GGGTCATCTC TTCTAGCAAA ATTTCCACCC 22301 CAGACCATGA TAAGTCCACA GTGCCACCTG ACACCTTCAC AGGAGAGATC 22351 CCCAGGGTCT TCACCTCCTC TATTAAGACA AAATCTGCAG AAATGACGAT 22401 CACCACCCAA GCAAGTCCTC CTGAGTCTGC ATCGCACAGT ACCCTTCCCT 22451 TGGACACATC AACCACACTT TCCCAGGGAG GGACTCATTC AACTGTGACT 22501 CAGGGATTCC CATACTCAGA GGTGACCACT CTCATGGGCA TGGGTCCTGG 22551 GAATGTGTCA TGGATGACAA CTCCCCCTGT GGAAGAAACC AGCTCTGTGT 22601 CTTCCCTGAT GTCTTCACCT GCCATGACAT CCCCTTCTCC TGTTTCCTCC 22651 ACATCACCAC AGAGCATCCC CTCCTCTCCT CTTCCTGTGA CTGCACTTCC 22701 TACTTCTGTT CTGGTGACAA CCACAGATGT GTTGGGCACA ACAAGCCCAG 22751 AGTCTGTAAC CAGTTCACCT CCAAATTTGA GCAGCATCAC TCATGAGAGA 22801 CCGGCCACTT ACAAAGACAC TGCACACACA GAAGCCGCCA TGCATCATTC 22851 CACAAACACC GCAGTGACCA ATGTAGGGAC TTCCGGGTCT GGACATAAAT 22901 CACAATCCTC TGTCCTAGCT GACTCAGAGA CATCGAAAGC CACACCTCTG 22951 ATGAGTACCA CCTCCACCCT GGGGGACACA AGTGTTTCCA CATCAACTCC 23001 TAATATCTCT CAGACTAACC AAATTCAAAC AGAGCCAACA GCATCCCTGA 23051 GCCCTAGACT GAGGGAGAGC AGCACGTCTG AGAAGACCAG CTCAACAACA 23101 GAGACAAATA CTGCCTTTTC TTATGTGCCC ACAGGTGCTA TTACTCAGGC 23151 CTCCAGAACA GAAATCTCCT CTAGCAGAAC ATCCATCTCA GACCTTGATC 23201 GGTCCACAAT AGCACCCGAC ATCTCCACAG GAATGATCAC CAGGCTCTTC 23251 ACCTCCCCCA TCATGACAAA ATCTGCAGAA ATGACCGTCA CCACTCAAAC 23301 AACTACTCCT GGGGCTACAT CACAGGGTAT CCTTCCCTGG GACACATCAA 23351 CCACACTTTT CCAGGGAGGG ACTCATTCAA CCGTGTCTCA GGGATTCCCA 23401 CACTCAGAGA TAACCACTCT TCGGAGCAGA ACCCCTGGAG ATGTGTCATG 23451 GATGACAACT CCCCCTGTGG AAGAAACCAG CTCTGGGTTT TCCCTGATGT 23501 CACCTTCCAT GACATCCCCT TCTCCTGTTT CCTCCACATC ACCAGAGAGC 23551 ATCCCCTCCT CTCCTCTCCC TGTGACTGCA CTTCTTACTT CTGTTCTGGT 23601 GACAACCACA AATGTATTGG GCACAACAAG CCCAGAGCCC GTAACGAGTT 23651 CACCTCCAAA TTTAAGCAGC CCCACACAGG AGAGACTGAC CACTTACAAA 23701 GACACTGCGC ACACAGAAGC CATGCATGCT TCCATGCATA CAAACACTGC 23751 AGTGGCCAAC GTGGGGACCT CCATTTCTGG ACATGAATCA CAATCTTCTG 23801 TCCCAGCTGA TTCAGACACA TCCAAAGCCA CATCTCCAAT GGGTACCACC 23851 TTCGCCATGG GGGATACAAG TGTTTCTACA TCAACTCCTG CCTTCTTTGA 23901 GACTAGAATT CAGACTGAAT CAACATCCTC TTTGATTCCT GGATTAAGGG 23951 ACACCAGGAC GTCTGAGGAG ATCAACACTG TGACAGAGAC CAGCACTGTC 24001 CTTTCAGAAG TGCCCACTAC TACTACTACT GAGGTCTCCA GGACAGAAGT 24051 TATCACTTCC AGCAGAACAA CCATCTCAGG GCCTGATCAT TCCAAAATGT 24101 CACCCTACAT CTCCACAGAA ACCATCACCA GGCTCTCCAC TTTTCCTTTT 24151 GTAACAGGAT CCACAGAAAT GGCCATCACC AACCAAACAG GTCCTATAGG 24201 GACTATCTCA CAGGCTACCC TTACCCTGGA CACATCAAGC ACAGCTTCCT 24251 GGGAAGGGAC TCACTCACCT GTGACTCAGA GATTTCCACA CTCAGAGGAG 24301 ACCACTACTA TGAGCAGAAG TACTAAGGGC GTGTCATGGC AAAGCCCTCC 24351 CTCTGTGGAA GAAACCAGTT CTCCTTCTTC CCCAGTGCCT TTACCTGCAA 24401 TAACCTCACA TTCATCTCTT TATTCCGCAG TATCAGGAAG TAGCCCCACT 24451 TCTGCTCTCC CTGTGACTTC CCTTCTCACC TCTGGCAGGA GGAAGACCAT 24501 AGACATGTTG GACACACACT CAGAACTTGT GACCAGCTCC TTACCAAGTG 24551 CAAGTAGCTT CTCAGGTGAG ATACTCACTT CTGAAGCCTC CACAAATACA 24601 GAGACAATTC ACTTTTCAGA GAACACAGCA GAAACCAATA TGGGGACCAC 24651 CAATTCTATG CATAAACTAC ATTCCTCTGT CTCAATCCAC TCCCAGCCAT 24701 CCGGACACAC ACCTCCAAAG GTTACTGGAT CTATGATGGA GGACGCTATT 24751 GTTTCCACAT CAACACCTGG TTCTCCTGAG ACTAAAAATG TTGACAGAGA 24801 CTCAACATCC CCTCTGACTC CTGAACTGAA AGAGGACAGC ACCGCCCTGG 24851 TGATGAACTC AACTACAGAG TCAAACACTG TTTTCTCCAG TGTGTCCCTG 24901 GATGCTGCTA CTGAGGTCTC CAGGGCAGAA GTCACCTACT ATGATCCTAC 24951 ATTCATGCCA GCTTCTGCTC AGTCAACAAA GTCCCCAGAC ATTTCACCTG 25001 AAGCCAGCAG CAGTCATTCT AACTCTCCTC CCTTGACAAT ATCTACACAC 25051 AAGACCATCG CCACACAAAC AGGTCCTTCT GGGGTGACAT CTCTTGGCCA 25101 ACTGACCCTG GACACATCAA CCATAGCCAC CTCAGCAGGA ACTCCATCAG 25151 CCAGAACTCA GGATTTTGTA GATTCAGAAA CAACCAGTGT CATGAACAAT 25201 GATCTCAATG ATGTGTTGAA GACAAGCCCT TTCTCTGCAG AAGAAGCCAA 25251 CTCTCTCTCT TCTCAGGCAC CTCTCCTTGT GACAACCTCA CCTTCTCCTG 25301 TAACTTCCAC ATTGCAAGAG CACAGTACCT CCTCTCTTGT TTCTGTGACC 25351 TCAGTACCCA CCCCTACACT GGCGAAGATC ACAGACATGG ACACAAACTT 25401 AGAACCTGTG ACTCGTTCAC CTCAAAATTT AAGGAACACC TTGGCCACTT 25451 CAGAAGCCAC CACAGATACA CACACAATGC ATCCTTCTAT AAACACAGCA 25501 GTGGCCAATG TGGGGACCAC CAGTTCACCA AATGAATTCT ATTTTACTGT 25551 CTCACCTGAC TCAGACCCAT ATAAAGCCAC ATCCGCAGTA GTTATCACTT 25601 CCACCTCGGG GGACTCAATA GTTTCCACAT CAATGCCTAG ATCCTCTGCG 25651 ATGAAAAAGA TTGAGTCTGA GACAACTTTC TCCCTGATAT TTAGACTGAG 25701 GGAGACTAGC ACCTCCCAGA AAATTGGCTC ATCCTCAGAC ACAAGCACGG 25751 TCTTTGACAA AGCATTCACT GCTGCTACTA CTGAGGTCTC CAGAACAGAA 25801 CTCACCTCCT CTAGCAGAAC ATCCATCCAA GGCACTGAAA AGCCCACAAT 25851 GTCACCGGAC ACCTCCACAA GATCTGTCAC CATGCTTTCT ACTTTTGCTG 25901 GCCTGACAAA ATCCGAAGAA AGGACCATTG CCACCCAAAC AGGTCCTCAT 25951 AGGGCGACAT CACAGGGTAC CCTTACCTGG GACACATCAA TCACAACCTC 26001 ACAGGCAGGG ACCCACTCAG CTATGACTCA TGGATTTTCA CAATTAGATT 26051 TGTCCACTCT TACGAGTAGA GTTCCTGAGT ACATATCAGG GACAAGCCCA 26101 CCCTCTGTGG AAAAAACCAG CTCTTCCTCT TCCCTTCTGT CTTTACCAGC 26151 AATAACCTCA CCGTCCCCTG TACCTACTAC ATTACCAGAA AGTAGGCCGT 26201 CTTCTCCTGT TCATCTGACT TCACTCCCCA CCTCTGGCCT AGTGAAGACC 26251 ACAGATATGC TGGCATCTGT GGCCAGTTTA CCTCCAAACT TGGGCAGCAC 26301 CTCACATAAG ATACCGACTA CTTCAGAAGA CATTAAAGAT ACAGAGAAAA 26351 TGTATCCTTC CACAAACATA GCAGTAACCA ATGTGGGGAC CACCACTTCT 26401 GAAAAGGAAT CTTATTCGTC TGTCCCAGCC TACTCAGAAC CACCCAAAGT 26451 CACCTCTCCA ATGGTTACCT CTTTCAACAT AAGGGACACC ATTGTTTCCA 26501 CATCCATGCC TGGCTCCTCT GAGATTACAA GGATTGAGAT GGAGTCAACA 26551 TTCTCCCTGG CTCATGGGCT GAAGGGAACC AGCACCTCCC AGGACCCCAT 26601 CGTATCCACA GAGAAAAGTG CTGTCCTTCA CAAGTTGACC ACTGGTGCTA 26651 CTGAGACCTC TAGGACAGAA GTTGCCTCTT CTAGAAGAAC ATCCATTCCA 26701 GGCCCTGATC ATTCCACAGA GTCACCAGAC ATCTCCACTG AAGTGATCCC 26751 CAGCCTGCCT ATCTCCCTTG GCATTACAGA ATCTTCAAAT ATGACCATCA 26801 TCACTCGAAC AGGTCCTCCT CTTGGCTCTA CATCACAGGG CACATTTACC 26851 TTGGACACAC CAACTACATC CTCCAGGGCA GGAACACACT CGATGGCGAC 26901 TCAGGAATTT CCACACTCAG AAATGACCAC TGTCATGAAC AAGGACCCTG 26951 AGATTCTATC ATGGACAATC CCTCCTTCTA TAGAGAAAAC CAGCTTCTCC 27001 TCTTCCCTGA TGCCTTCACC AGCCATGACT TCACCTCCTG TTTCCTCAAC 27051 ATTACCAAAG ACCATTCACA CCACTCCTTC TCCTATGACC TCACTGCTCA 27101 CCCCTAGCCT AGTGATGACC ACAGACACAT TGGGCACAAG CCCAGAACCT 27151 ACAACCAGTT CACCTCCAAA TTTGAGCAGT ACCTCACATG AGATACTGAC 27201 AACAGATGAA GACACCACAG CTATAGAAGC CATGCATCCT TCCACAAGCA 27251 CAGCAGCGAC TAATGTGGAA ACCACCAGTT CTGGACATGG GTCACAATCC 27301 TCTGTCCTAG CTGACTCAGA AAAAACCAAG GCCACAGCTC CAATGGATAC 27351 CACCTCCACC ATGGGGCATA CAACTGTTTC CACATCAATG TCTGTTTCCT 27401 CTGAGACTAC AAAAATTAAG AGAGAGTCAA CATATTCCTT GACTCCTGGA 27451 CTGAGAGAGA CCAGCATTTC CCAAAATGCC AGCTTTTCCA CTGACACAAG 27501 TATTGTTCTT TCAGAAGTCC CCACTGGTAC TACTGCTGAG GTCTCCAGGA 27551 CAGAAGTCAC CTCCTCTGGT AGAACATCCA TCCCTGGCCC TTCTCAGTCC 27601 ACAGTTTTGC CAGAAATATC CACAAGAACA ATGACAAGGC TCTTTGCCTC 27651 GCCCACCATG ACAGAATCAG CAGAAATGAC CATCCCCACT CAAACAGGTC 27701 CTTCTGGGTC TACCTCACAG GATACCCTTA CCTTGGACAC ATCCACCACA 27751 AAGTCCCAGG CAAAGACTCA TTCAACTTTG ACTCAGAGAT TTCCACACTC 27801 AGAGATGACC ACTCTCATGA GCAGAGGTCC TGGAGATATG TCATGGCAAA 27851 GCTCTCCCTC TCTGGAAAAT CCCAGCTCTC TCCCTTCCCT GCTGTCTTTA 27901 CCTGCCACAA CCTCACCTCC TCCCATTTCC TCCACATTAC CAGTGACTAT 27951 CTCCTCCTCT CCTCTTCCTG TGACTTCACT TCTCACCTCT AGCCCGGTAA 28001 CGACCACAGA CATGTTACAC ACAAGCCCAG AACTTGTAAC CAGTTCACCT 28051 CCAAAGCTGA GCCACACTTC AGATGAGAGA CTGACCACTG GCAAGGACAC 28101 CACAAATACA GAAGCTGTGC ATCCTTCCAC AAACACAGCA GCGTCCAATG 28151 TGGAGATTCC CAGCTCTGGA CATGAATCCC CTTCCTCTGC CTTAGCTGAC 28201 TCAGAGACAT CCAAAGCCAC ATCACCAATG TTTATTACCT CCACCCAGGA 28251 GGATACAACT GTTGCCATAT CAACCCCTCA CTTCTTGGAG ACTAGCAGAA 28301 TTCAGAAAGA GTCAATTTCC TCCCTGAGCC CTAAATTGAG GGAGACAGGC 28351 AGTTCTGTGG AGACAAGCTC AGCCATAGAG ACAAGTGCTG TCCTTTCTGA 28401 AGTGTCCGTT GGTGCTACTA CTGAGATCTC CAGGACAGAA GTCACCTCCT 28451 CTAGCAGAAC ATCCATCTCT GGTTCTGCTG AGTCCACAAT GTTGCCAGAA 28501 ATATCCACCA CAAGAAAAAT CATTAAGTTC CCTACTTCCC CCATCCTGGC 28551 AGAATCATCA GAAATGACCA TCAAGACCCA AACAAGTCCT CCTGGGTCTA 28601 CATCAGAGAG TACCTTTACA TTAGACACAT CAACCACTCC CTCCTTGGTA 28651 ATAACCCATT CGACTATGAC TCAGAGATTG CCACACTCAG AGATAACCAC 28701 TCTTGTGAGT AGAGGTGCTG GGGATGTGCC ACGGCCCAGC TCTCTCCCTG 28751 TGGAAGAAAC AAGCCCTCCA TCTTCCCAGC TGTCTTTATC TGCCATGATC 28801 TCACCTTCTC CTGTTTCTTC CACATTACCA GCAAGTAGCC ACTCCTCTTC 28851 TGCTTCTGTG ACTTCACTTC TCACACCAGG CCAAGTGAAG ACTACTGAGG 28901 TGTTGGACGC AAGTGCAGAA CCTGAAACCA GTTCACCTCC AAGTTTGAGC 28951 AGCACCTCAG TTGAAATACT GGCCACCTCT GAAGTCACCA CAGATACGGA 29001 GAAAATTCAT CCTTTCTCAA ACACGGCAGT AACCAAAGTT GGAACTTCCA 29051 GTTCTGGACA TGAATCCCCT TCCTCTGTCC TACCTGACTC AGAGACAACC 29101 AAAGCCACAT CGGCAATGGG TACCATCTCC ATTATGGGGG ATACAAGTGT 29151 TTCTACATTA ACTCCTGCCT TATCTAACAC TAGGAAAATT CAGTCAGAGC 29201 CAGCTTCCTC ACTGACCACC AGATTGAGGG AGACCAGCAC CTCTGAAGAG 29251 ACCAGCTTAG CCACAGAAGC AAACACTGTT CTTTCTAAAG TGTCCACTGG 29301 TGCTACTACT GAGGTCTCCA GGACAGAAGC CATCTCCTTT AGCAGAACAT 29351 CCATGTCAGG CCCTGAGCAG TCCACAATGT CACAAGACAT CTCCATAGGA 29401 ACCATCCCCA GGATTTCTGC CTCCTCTGTC CTGACAGAAT CTGCAAAAAT 29451 GACCATCACA ACCCAAACAG GTCCTTCGGA GTCTACACTA GAAAGTACCC 29501 TTAATTTGAA CACAGCAACC ACACCCTCTT GGGTGGAAAC CCACTCTATA 29551 GTAATTCAGG GATTTCCACA CCCAGAGATG ACCACTTCCA TGGGCAGAGG 29601 TCCTGGAGGT GTGTCATGGC CTAGCCCTCC CTTTGTGAAA GAAACCAGCC 29651 CTCCATCCTC CCCGCTGTCT TTACCTGCCG TGACCTCACC TCATCCTGTT 29701 TCCACCACAT TCCTAGCACA TATCCCCCCC TCTCCCCTTC CTGTGACTTC 29751 ACTTCTCACC TCTGGCCCGG CGACAACCAC AGATATCTTG GGTACAAGCA 29801 CAGAACCTGG AACCAGTTCA TCTTCAAGTT TGAGCACCAC CTCCCATGAG 29851 AGACTGACCA CTTACAAAGA CACTGCACAT ACAGAAGCCG TGCATCCTTC 29901 CACAAACACA GGAGGGACCA ATGTGGCAAC CACCAGCTCT GGATATAAAT 29951 CACAGTCCTC TGTCCTAGCT GACTCATCTC CAATGTGTAC CACCTCCACC 30001 ATGGGGGATA CAAGTGTTCT CACATCAACT CCTGCCTTCC TTGAGACTAG 30051 GAGGATTCAG ACAGAGCTAG CTTCCTCCCT GACCCCTGGA TTGAGGGAGT 30101 CCAGTGGCTC TGAAGGGACC AGCTCAGGCA CCAAGATGAG CACTGTCCTC 30151 TCTAAAGTGC CCACTGGTGC TACTACTGAG ATCTCCAAGG AAGACGTCAC 30201 CTCCATCCCA GGTCCCGCTC AATCCACAAT ATCACCAGAC ATCTCCACAA 30251 GAACCGTCAG CTGGTTCTCT ACATCCCCTG TCATGACAGA ATCAGCAGAA 30301 ATAACCATGA ACACCCATAC AAGTCCTTTA GGGGCCACAA CACAAGGCAC 30351 CAGTACTTTG GCCACGTCAA GCACAACCTC TTTGACAATG ACACACTCAA 30401 CTATATCTCA AGGATTTTCA CACTCACAGA TGAGCACTCT TATGAGGAGG 30451 GGTCCTGAGG ATGTATCATG GATGAGCCCT CCCCTTCTGG AAAAAACTAG 30501 ACCTTCCTTT TCTCTGATGT CTTCACCAGC CACAACTTCA CCTTCTCCTG 30551 TTTCCTCCAC ATTACCAGAG AGCATCTCTT CCTCTCCTCT TCCTGTGACT 30601 TCACTCCTCA CGTCTGGCTT GGCAAAAACT ACAGATATGT TGCACAAAAG 30651 CTCAGAACCT GTAACCAACT CACCTGCAAA TTTGAGCAGC ACCTCAGTTG 30701 AAATACTGGC CACCTCTGAA GTCACCACAG ATACAGAGAA AACTCATCCT 30751 TCTTCAAACA GAACAGTGAC CGATGTGGGG ACCTCCAGTT CTGGACATGA 30801 ATCCACTTCC TTTGTCCTAG CTGACTCACA GACATCCAAA GTCACATCTC 30851 CAATGGTTAT TACCTCCACC ATGGAGGATA CGAGTGTCTC CACATCAACT 30901 CCTGGCTTTT TTGAGACTAG CAGAATTCAG ACAGAACCAA CATCCTCCCT 30951 GACCCTTGGA CTGAGAAAGA CCAGCAGCTC TGAGGGGACC AGCTTAGCCA 31001 CAGAGATGAG CACTGTCCTT TCTGGAGTGC CCACTGGTGC CACTGCTGAA 31051 GTCTCCAGGA CAGAAGTCAC CTCCTCTAGC AGAACATCCA TCTCAGGCTT 31101 TGCTCAGCTC ACAGTGTCAC CAGAGACTTC CACAGAAACC ATCACCAGAC 31151 TCCCTACCTC CAGCATAATG ACAGAATCAG CAGAAATGAT GATCAAGACA 31201 CAAACAGATC CTCCTGGGTC TACACCAGAG AGTACTCATA CTGTGGACAT 31251 ATCAACAACA CCCAACTGGG TAGAAACCCA CTCGACTGTG ACTCAGAGAT 31301 TTTCACACTC AGAGATGACC ACTCTTGTGA GCAGAAGCCC TGGTGATATG 31351 TTATGGCCTA GTCAATCCTC TGTGGAAGAA ACCAGCTCTG CCTCTTCCCT 31401 GCTGTCTCTG CCTGCCACGA CCTCACCTTC TCCTGTTTCC TCTACATTAG 31451 TAGAGGATTT CCCTTCCGCT TCTCTTCCTG TGACTTCTCT TCTCACCCCT 31501 GGCCTGGTGA TAACCACAGA CAGGATGGGC ATAAGCAGAG AACCTGGAAC 31551 CAGTTCCACT TCAAATTTGA GCAGCACCTC CCATGAGAGA CTGACCACTT 31601 TGGAAGACAC TGTAGATACA GAAGACATGC AGCCTTCCAC ACACACAGCA 31651 GTGACCAACG TGAGGACCTC CATTTCTGGA CATGAATCAC AATCTTCTGT 31701 CCTATCTGAC TCAGAGACAC CCAAAGCCAC ATCTCCAATG GGTACCACCT 31751 ACACCATGGG GGAAACGAGT GTTTCCATAT CCACTTCTGA CTTCTTTGAG 31801 ACCAGCAGAA TTCAGATAGA ACCAACATCC TCCCTGACTT CTGGATTGAG 31851 GGAGACCAGC AGCTCTGAGA GGATCAGCTC AGCCACAGAG GGAAGCACTG 31901 TCCTTTCTGA AGTGCCCAGT GGTGCTACCA CTGAGGTCTC CAGGACAGAA 31951 GTGATATCCT CTAGGGGAAC ATCCATGTCA GGGCCTGATC AGTTCACCAT 32001 ATCACCAGAC ATCTCTACTG AAGCGATCAC CAGGCTTTCT ACTTCCCCCA 32051 TTATGACAGA ATCAGCAGAA AGTGCCATCA CTATTGAGAC AGGTTCTCCT 32101 GGGGCTACAT CAGAGGGTAC CCTCACCTTG GACACCTCAA CAACAACCTT 32151 TTGGTCAGGG ACCCACTCAA CTGCATCTCC AGGATTTTCA CACTCAGAGA 32201 TGACCACTCT TATGAGTAGA ACTCCTGGAG ATGTGCCATG GCCGAGCCTT 32251 CCCTCTGTGG AAGAAGCCAG CTCTGTCTCT TCCTCACTGT CTTCACCTGC 32301 CATGACCTCA ACTTCTTTTT TCTCCACATT ACCAGAGAGC ATCTCCTCCT 32351 CTCCTCATCC TGTGACTGCA CTTCTCACCC TTGGCCCAGT GAAGACCACA 32401 GACATGTTGC GCACAAGCTC AGAACCTGAA ACCAGTTCAC CTCCAAATTT 32451 GAGCAGCACC TCAGCTGAAA TATTAGCCAC GTCTGAAGTC ACCAAAGATA 32501 GAGAGAAAAT TCATCCCTCC TCAAACACAC CTGTAGTCAA TGTAGGGACT 32551 GTGATTTATA AACATCTATC CCCTTCCTCT GTTTTGGCTG ACTTAGTGAC 32601 AACAAAACCC ACATCTCCAA TGGCTACCAC CTCCACTCTG GGGAATACAA 32651 GTGTTTCCAC ATCAACTCCT GCCTTCCCAG AAACTATGAT GACACAGCCA 32701 ACTTCCTCCC TGACTTCTGG ATTAAGGGAG ATCAGTACCT CTCAAGAGAC 32751 CAGCTCAGCA ACAGAGAGAA GTGCTTCTCT TTCTGGAATG CCCACTGGTG 32801 CTACTACTAA GGTCTCCAGA ACAGAAGCCC TCTCCTTAGG CAGAACATCC 32851 ACCCCAGGTC CTGCTCAATC CACAATATCA CCAGAAATCT CCACGGAAAC 32901 CATCACTAGA ATTTCTACTC CCCTCACCAC GACAGGATCA GCAGAAATGA 32951 CCATCACCCC CAAAACAGGT CATTCTGGGG CATCCTCACA AGGTACCTTT 33001 ACCTTGGACA CATCAAGCAG AGCCTCCTGG CCAGGAACTC ACTCAGCTGC 33051 ATCTCACAGA TCTCCACACT CAGGGATGAC CACTCCTATG AGCAGAGGTC 33101 CTGAGGATGT GTCATGGCCA AGCCGCCCAT CAGTGGAAAA AACTAGCCCT 33151 CCATCTTCCC TGGTGTCTTT ATCTGCAGTA ACCTCACCTT CGCCACTTTA 33201 TTCCACACCA TCTGAGAGTA GCCACTCATC TCCTCTCCGG GTGACTTCTC 33251 TTTTCACCCC TGTCATGATG AAGACCACAG ACATGTTGGA CACAAGCTTG 33301 GAACCTGTGA CCACTTCACC TCCCAGTATG AATATCACCT CAGATGAGAG 33351 TCTGGCCACT TCTAAAGCCA CCATGGAGAC AGAGGCAATT CAGCTTTCAG 33401 AAAACACAGC TGTGACTCAG ATGGGCACCA TCAGCGCTAG ACAAGAATTC 33451 TATTCCTCTT ATCCAGGCCT CCCAGAGCCA TCCAAAGTGA CATCTCCAGT 33501 GGTCACCTCT TCCACCATAA AAGACATTGT TTCTACAACC ATACCTGCTT 33551 CCTCTGAGAT AACAAGAATT GAGATGGAGT CAACATCCAC CCTGACCCCC 33601 ACACCAAGGG AGACCAGCAC CTCCCAGGAG ATCCACTCAG CCACAAAGCC 33651 AAGCACTGTT CCTTACAAGG CACTCACTAG TGCCACGATT GAGGACTCCA 33701 TGACACAAGT CATGTCCTCT AGCAGAGGAC CTAGCCCTGA TCAGTCCACA 33751 ATGTCACAAG ACATATCCAG TGAAGTGATC ACCAGGCTCT CTACCTCCCC 33801 CATCAAGGCA GAATCTACAG AAATGACCAT TACCACCCAA ACAGGTTCTC 33851 CTGGGGCTAC ATCAAGGGGT ACCCTTACCT TGGACACTTC AACAACTTTT 33901 ATGTCAGGGA CCCACTCAAC TGCATCTCAA GGATTTTCAC ACTCACAGAT 33951 GACCGCTCTT ATGAGTAGAA CTCCTGGAGA TGTGCCATGG CTAAGCCATC 34001 CCTCTGTGGA AGAAGCCAGC TCTGCCTCTT TCTCACTGTC TTCACCTGTC 34051 ATGACCTCAT CTTCTCCCGT TTCTTCCACA TTACCAGACA GCATCCACTC 34101 TTCTTCGCTT CCTGTGACAT CACTTCTCAC CTCAGGGCTG GTGAAGACCA 34151 CAGAGCTGTT GGGCACAAGC TCAGAACCTG AAACCAGTTC ACCCCCAAAT 34201 TTGAGCAGCA CCTCAGCTGA AATACTGGCC ACCACTGAAG TCACTACAGA 34251 TACAGAGAAA CTGGAGATGA CCAATGTGGT AACCTCAGGT TATACACATG 34301 AATCTCCTTC CTCTGTCCTA GCTGACTCAG TGACAACAAA GGCCACATCT 34351 TCAATGGGTA TCACCTACCC CACAGGAGAT ACAAATGTTC TCACATCAAC 34401 CCCTGCCTTC TCTGACACCN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 34451 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 34501 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNCGGAAA CCAAGTTTCT Exon 4 34551 AACCAACCCC TCCTTTTTGA CCCCAGTAGG ATTCAAACAA AGTCAAAGCT 34601 CTCACTGACT CCTGGGTTGA TGGAGACCAG CATCTCTGAA GAGACCAGCT 34651 CTGCCACAGA AAAAAGCACT GTCCTTTCTA GTGTGCCCAC TGGTGCTACT 34701 ACTGAGGTCT CCAGGACAGA AGCCATCTCT TCTAGCAGAA CATCCATCCC 34751 AGGCCCTGCT CAATCCACAA TGTCATCAGA CACCTCCATG GAAACCATCA 34801 CTAGAATTTC TACCCCCCTC ACAAGGAAAG AATCAACAGA CATGGCCATC 34851 ACCCCCAAAA CAGGTCCTTC TGGGGCTACC TCGCAGGGTA CCTTTACCTT 34901 GGACTCATCA AGCACAGCCT CCTGGCCAGG AACTCACTCA GCTACAACTC 34951 AGAGATTTCC ACAGTCAGTG GTGACAACTC CTATGAGCAG AGGTCCTGAG 35001 GATGTGTCAT GGCCAAGCCC GCTGTCTGTG GAAAAAAACA GCCCTCCATC 35051 TTCCCTGGTA TCTTCATCTT CAGTAACCTC ACCTTCGCCA CTTTATTCCA 35101 CACCATCTGG GAGTAGCCAC TCCTCTCCTG TCCCTGTCAC TTCTCTTTTC 35151 ACCTCTATCA TGATGAAGGC CACAGACATG TTGGATGCAA GTTTGGAACC 35201 TGAGACCACT TCAGCTCCCA ATATGAATAT CACCTCAGAT GAGAGTCTGG 35251 CCACTTCTAA AGCCACCACG GAGACAGAGG CAATTCACGT TTTTGAAAAT 35301 ACAGCAGCGT CCCATGTGGA AACCACCAGT GCTACAGAGG AACTCTATTC 35351 CTCTTCCCCA GGCTTCTCAG AGCCAACAAA AGTGATATCT CCAGTGGTCA 35401 CCTCTTCCTC TATAAGAGAC AACATGGTTT CCACAACAAT GCCTGGCTCC 35451 TCTGGCATTA CAAGGATTGA GATAGAGTCA ATGTCATCTC TGACCCCTGG 35501 ACTGAGGGAG ACCAGAACCT CCCAGGACAT CACCTCATCC ACAGAGACAA 35551 GCACTGTCCT TTACAAGATG TCCTCTGGTG CCACTCCTGA GGTCTCCAGG 35601 ACAGAAGTTA TGCCCTCTAG CAGAACATCC ATTCCTGGCC CTGCTCAGTC 35651 CACAATGTCA CTAGACATCT CCGATGAAGT TGTCACCAGG CTGTCTACCT 35701 CTCCCATCAT GACAGAATCT GCAGAAATAA CCATCACCAC CCAAACAGGT 35751 TATTCTCTGG CTACATCCCA GGTTACCCTT CCCTTGGGCA CCTCAATGAC 35801 CTTTTTGTCA GGGACCCACT CAACTATGTC TCAAGGACTT TCACACTCAG 35851 AGATGACCAA TCTTATGAGC AGGGGTCCTG AAAGTCTGTC ATGGACGAGC 35901 CCTCGCTTTG TGGAAACAAC TAGATCTTCC TCTTCTCTGA CATCATTACC 35951 TCTCACGACC TCACTTTCTC CTGTGTCCTC CACATTACTA GACAGTAGCC 36001 CCTCCTCTCC TCTTCCTGTG ACTTCACTTA TCCTCCCAGG CCTGGTGAAG 36051 ACTACAGAAG TGTTGGATAC AAGCTCAGAG CCTAAAACCA GTTCATCTCC 36101 AAATTTGAGC AGCACCTCAG TTGAAATACC GGCCACCTCT GAAATCATGA 36151 CAGATACAGA GAAAATTCAT CCTTCCTCAA ACACAGCGGT GGCCAAAGTG 36201 AGGACCTCCA GTTCTGTTCA TGAATCTCAT TCCTCTGTCC TAGCTGACTC 36251 AGAAACAACC ATAACCATAC CTTCAATGGG TATCACCTCC GCTGTGGACG 36301 ATACCACTGT TTTCACATCA AATCCTGCCT TCTCTGAGAC TAGGAGGATT 36351 CCGACAGAGC CAACATTCTC ATTGACTCCT GGATTCAGGG AGACTAGCAC 36401 CTCTGAAGAG ACCACCTCAA TCACAGAAAC AAGTGCAGTC CTTTATGGAG 36451 TGCCCACTAG TGCTACTACT GAAGTCTCCA TGACAGAAAT CATGTCCTCT 36501 AATAGAACAC ACATCCCTGA CTCTGATCAG TCCACGATGT CTCCAGACAT 36551 CATCACTGAA GTGATCACCA GGCTCTCTTC CTCATCCATG ATGTCAGAAT 36601 CAACACAAAT GACCATCACC ACCCAAAAAA GTTCTCCTGG GGCTACAGCA 36651 CAGAGTACTC TTACCTTGGC CACAACAACA GCCCCCTTGG CAAGGACCCA 36701 CTCAACTGTT CCTCCTAGAT TTTTACACTC AGAGATGACA ACTCTTATGA 36751 GTAGGAGTCC TGAAAATCCA TCATGGAAGA GCTCTCCCTT TGTGGAAAAA 36801 ACTAGCTCTT CATCTTCTCT GTTGTCCTTA CCTGTCACGA CCTCACCTTC 36851 TGTTTCTTCC ACATTACCGC AGAGTATCCC TTCCTCCTCT TTTTCTGTGA 36901 CTTCACTCCT CACCCCAGGC ATGGTGAAGA CTACAGACAC AAGCACAGAA 36951 CCTGGAACCA GTTTATCTCC AAATCTGAGT GGCACCTCAG TTGAAATACT 37001 GGCTGCCTCT GAAGTCACCA CAGATACAGA GAAAATTCAT CCTTCTTCAA 37051 GCATGGCAGT GACCAATGTG GGAACCACCA GTTCTGGACA TGAACTATAT 37101 TCCTCTGTTT CAATCCACTC GGAGCCATCC AAGGCTACAT ACCCAGTGGG 37151 TACTCCCTCT TCCATGGCTG AAACCTCTAT TTCCACATCA ATGCCTGCTA 37201 ATTTTGAGAC CACAGGATTT GAGGCTGAGC CATTTTCTCA TTTGACTTCT 37251 GGATTTAGGA AGACAAACAT GTCCCTGGAC ACCAGCTCAG TCACACCAAC 37301 AAATACACCT TCTTCTCCTG GGTCCACTCA CCTTTTACAG AGTTCCAAGA 37351 CTGATTTCAC CTCTTCTGCA AAAACATCAT CCCCAGACTG GCCTCCAGCC 37401 TCACAGTATA CTGAAATTCC AGTGGACATA ATCACCCCCT TTAATGCTTC 37451 TCCATCTATT ACGGAGTCCA CTGGGATAAC CTCCTTCCCA GAATCCAGGT 37501 TTACTATGTC TGTAACAGAA AGTACTCATC ATCTGAGTAC AGATTTGCTG 37551 CCTTCAGCTG AGACTATTTC CACTGGCACA GTGATGCCTT CTCTATCAGA 37601 GGCCATGACT TCATTTGCCA CCACTGGAGT TCCACGAGCC ATCTCAGGTT 37651 CAGGTAGTCC ATTCTCTAGG ACAGAGTCAG GCCCTGGGGA TGCTACTCTG 37701 TCCACCATTG CAGAGAGCCT GCCTTCATCC ACTCCTGTGC CATTCTCCTC 37751 TTCAACCTTC ACTACCACTG ATTCTTCAAC CATCCCAGCC CTCCATGAGA 37801 TAACTTCCTC TTCAGCTACC CCATATAGAG TGGACACCAG TCTTGGGACA 37851 GAGAGCAGCA CTACTGAAGG ACGCTTGGTT ATGGTCAGTA CTTTGGACAC 37901 TTCAAGCCAA CCAGGCAGGA CATCTTCAAC ACCCATTTTG GATACCAGAA 37951 TGACAGAGAG CGTTGAGCTG GGAACAGTGA CAAGTGCTTA TCAAGTTCCT 38001 TCACTCTCAA CACGGTTGAC AAGAGAATGC GCATGGCGAG AAGGGAGAAG 38051 TGTAGTTGGA TGGATAAAAG GAAGAATGGA GAGAAGAGTG AATGGAAGGA 38101 AGCAAAGATG AAGCGGAGGA AGGATAGATG CACAGAAGGA AGGATGAAAA 38151 GAAAGAAAGA TGATGGAAGA CAGGATTGAA GGGGATATAG ATTGAAGGAA 38201 AGAAAGGTAG AAGGATGAAA TGAAGTAAAG ATTGAAGAAA AGATGGATGG 38251 AAAGAAGAAA GGAGGGTGCA CAAAAAATCT CACACTTCAC CACATATGAT 38301 TCATCCATAT AAGAAAAAAC CACTTGTACC CTCAAAGCTA TTGAAATACA 38351 AACTTTTAAA TTAAAATTTT PAAAAGCAAG AGAAAGGAAA GAAGGGAGGA 38401 AAGACAAAAG GAAGAATGGG TGATAGAAGG AAAGAATAAA AGGAAGAAAA 38451 AATGGAAGAA TAGATGATCA GATCTAGGGA TGAATGAAAG GAAGGATGGA 38501 CAAATCTATA GGTAGGTGGA TGGATCTATG GACAGGTGTG GCCACTTATG 38551 GCACATAGTC CCAGCTCCAG TTCATACTGA TGGACTTGAG GAGTGTTTGT 38601 GGCCATTGAA GTGGATCCAT TTAGACAGTG CTCTTCTTCT GAATGAGATG Exon 5 38651 AGTTACCCCA GTTTTTCTCC CCACCTTCAT CTTCAGGAAC TGATGGCATT 38701 ATGGAACACA TCACAAAAAT ACCCAATGAA GCAGCACACA GAGGTACCAT 38751 AAGACCAGTC AAAGGCCCTC AGACATCCAC TTCGCCTGCC AGTCCTAAAG 38801 GTAGGTTTAA CTTTGCTTAC CTCCCAGTAA TGCCACTCGT GACCATATTT 38851 CCTCCTCCAG AGAGACAAAA TGTTTGTATT CTTTAGAGAG AGAATTGTGT 38901 GTGGTTGTCA TAGGTTTCCC TGTCTGAACT GAGTCTTTAT CTAATGGTTA 38951 CCAGGCAGAT GTTACCACTG TCTCTTTCTC CTCATGGCAT GCTGAGTGAG 39001 TTTTGTCCAA CATCAAATAT TCACAAATTT GTCCATATTA ACCAAATTTT 39051 AAAAATGCTC ATTAAAAACT TACTATGAGC TGGGCGCAGT GGCTCATGCC 39101 TGTAATCCCA ATACTTTGGG AGGCTGAGCT GGGTGGATCA CCAGAGGTCA 39151 AAAATTCGAG ACCAGTCTGA CCAAAATGGT GAAACTCCAT CTCTACTGAA 39201 AATATAAAAA TTAGCCGGGC ATGGTGGCAC ACACCGTAAT CACAGCTACT 39251 CAGGAGGCTG AGGCAAGAGA GTCACTTGAA CCACAGGAGG TAGAGGCTGC 39301 AGTGAGCTGA GCATTGTGCC AATGCACTCC AGCCTGGGTG GCAGAGCAAG 39351 ACTCCAGCTC AGAAATAAAT AATATATTAT ATATATATAT ATATGTTTTA 39401 TTTAGATGGA ATATACTATA TATATATGTA TATATATATG TATGTATATA 39451 TATATATGTA TGTATATATA TATATATATA TATATATATA TATATAGAGA 39501 GAGAGAGAGA GAGAGAGAGA GAGAGAGACA GAGTATGTCT GAGAATGCAT 39551 CCCGATAGTT CTAGCAAGGT AGGAAAAGGA AGTATCATAA CAGCCTTGAA 39601 GTAGCCTGTT GAAACAGACA GACTCTCTTG TAAGAGAACT CACAAAATCT 39651 AGGATTATAT CTCCCATGAT GAAAAATTTG GAACTGTACA TTTTTGTTTA 39701 ACTGTCACTT AAATNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 39751 NNNNNNNNNN NNNNNNNNNN NCCAGGAGGC ACTGTGCTTG GCGCCTTTTT 39801 ACCAACACTT TGAGATGGCC ATTGTACTTA TCCCCACTTT ATAGACGGGA 39851 AAATGGAGGT CCAGCAATAT TTTTTAACTT AAAGAGCCAC CCATCTCTTT 39901 AGAGAAAGAG CCAGAATCCC AGGCAGGGGC TATCTTATTC CAGAGCCCAA 39951 GCTCTCAAAC ACATGATACA CAATACTTAA TCTCTCTCAA GTCAGAGGAG 40001 ATCCACTTAA GTATACATCC ATCCACATAT TCATTCATTC AATCATTCAA 40051 CAAATATTAG TTGAGCACTT ACCGTATGCC AAACAGTCAA ACGTGAATAG 40101 CTGTTACAAA TGAGACTGTG AAGGATGGTA CAACGCAGAT TCAGACAGTG 40151 TGATAAGGAA ATATTGAGAA GCAAAGATGA GTTCTGGAGT GAATTTGTAA 40201 AGGTGGATGT GGGCTTGGAT TTCAATAATG GCAGAACTTA AGGAATCTGA 40251 TGAGAAGTGG GCACTTCAGG CAGAGAGAAG AGCTTGAACA AGGCTCAGAG 40301 GCTGACAGTG CAGGAAACAC ATGGGAAGAG GGAATAGAGT AGCGGTCAAG 40351 AATTCACAGA GGAGTTATAG GTGAAGATGC AACCAAGTTA CAGACCAAGG 40401 TAAGATAGGG GAATACCAAT CACAATCTCT TTTCCCATTC CAGAAGCATC 40451 CCAGACACAT CCTAGTAACC GAGAGACATT TCTCTCCCTT TCCTCCTGTG 40501 GAGAATAAAT AAGCTATTGC AAGTCCAGTA AGTGTAATCA TTTTGTTCAA Exon 6 40551 ATTGTGTGCC CATTCCCCAA TTTACAGGAC TACACACAGG AGGGACAAAA 40601 AGAATGGAGA CCACAACCAC AGCTCTGAAG ACCACCACCA CAGCTCTGAA 40651 GACCACTTCC AGAGCCACCT TGACCACCAG TGTCTATACT CCCACTTTGG 40701 GAACACTGAC TCCCCTCAAT GCATCAATGC AAATGGCCAG CACAATCCCC 40751 ACAGAAATGA TGATCACAAC CCCATATGTT TTCCCTGATG TTCCAGAAAC 40801 GACATCCTCA TTGGCTACCA GCCTGGGAGC AGAAACCAGC ACAGCTCTTC 40851 CCAGGACAAC CCCATCTGTT TTCAATAGAG AATCAGAGAC CACAGCCTCA 40901 CTGGTCTCTC GTTCTGGGGC AGAGAGAAGT CCGGTTATTC AAACTCTAGA 40951 TGTTTCTTCT AGTGAGCCAG ATACAACAGC TTCATGGGTT ATCCATCCTG 41001 CAGAGACCAT CCCAACTGTT TCCAAGACAA CCCCCAATTT TTTCCACAGT 41051 GAATTAGACA CTGTATCTTC CACAGCCACC AGTCATGGGG CAGACGTCAG 41101 CTCAGCCATT CCAACAAATA TCTCACCTAG TGAACTAGAT GCACTGACCC 41151 CACTGGTCAC TATTTCGGGG ACAGATACTA GTACAACATT CCCAACACTG 41201 ACTAAGTCCC CACATGAAAC AGAGACAAGA ACCACATGGC TCACTCATCC 41251 TGCAGAGACC AGCTCAACTA TTCCCAGAAC AATCCCCAAT TTTTCTCATC 41301 ATGAATCAGA TGCCACACCT TCAATAGCCA CCAGTCCTGG GGCAGAAACC 41351 AGTTCAGCTA TTCCAATTAT GACTGTCTCA CCTGGTGCAG AAGATCTGGT 41401 GACCTCACAG GTCACTAGTT CTGGGACAGA CAGAAATATG ACTATTCCAA 41451 CTTTGACTCT TTCTCCTGGT GAACCAAAGA CGATAGCCTC ATTAGTCACC 41501 CATCCTGAAG CACAGACAAG TTCGGCCATT CCAACTTCAA CTATCTCGCC 41551 TGCTGTATCA CGGTTGGTGA CCTCAATGGT CACCAGTTTG GCGGCAAAGA 41601 CAAGTACAAC TAATCGAGCT CTGACAAACT CCCCTGGTGA ACCAGCTACA 41651 ACAGTTTCAT TGGTCACGCA TCCTGCACAG ACCAGCCCAA CAGTTCCCTG 41701 GACAACTTCC ATTTTTTTCC ATAGTAAATC AGACACCACA CCTTCAATGA 41751 CCACCAGTCA TGGGGCAGAA TCCAGTTCAG CTGTTCCAAC TCCAACTGTT 41801 TCAACTGAGG TACCAGGAGT AGTGACCCCT TTGGTCACCA GTTCTAGGGC 41851 AGTGATCAGT ACAACTATTC CAATTCTGAC TCTTTCTCCT GGTGAACCAG 41901 AGACCACACC TTCAATGGCC ACCAGTCATG GGGAAGAAGC CAGTTCTGCT 41951 ATTCCAACTC CAACTGTTTC ACCTGGGGTA CCAGGAGTGG TGACCTCTCT 42001 GGTCACTAGT TCTAGGGCAG TGACTAGTAC AACTATTCCA ATTCTGACTT 42051 TTTCTCTTGG TGAACCAGAG ACCACACCTT CAATGGCCAC CAGTCATGGG 42101 ACAGAAGCTG GCTCAGCTGT TCCAACTGTT TTACCTGAGG TACCAGGAAT 42151 GGTGACCTCT CTGGTTGCTA GTTCTAGGGC AGTAACCAGT ACAACTCTTC 42201 CAACTCTGAC TCTTTCTCCT GGTGAACCAG AGACCACACC TTCAATGGCC 42251 ACCAGTCATG GGGCAGAAGC CAGCTCAACT GTTCCAACTG TTTCACCTGA 42301 GGTACCAGGA GTGGTGACCT CTCTGGTCAC TAGTTCTAGT GGAGTAAACA 42351 GTACAAGTAT TCCAACTCTG ATTCTTTCTC CTGGTGAACT AGAAACCACA 42401 CCTTCAATGG CCACCAGTCA TGGGGCAGAA GCCAGCTCAG CTGTTCCAAC 42451 TCCAACTGTT TCACCTGGGG TATCAGGAGT GGTGACCCCT CTGGTCACTA 42501 GTTCCAGGGC AGTGACCAGT ACAACTATTC CAATTCTAAC TCTTTCTTCT 42551 AGTGAGCCAG AGACCACACC TTCAATGGCC ACCAGTCATG GGGTAGAAGC 42601 CAGCTCAGCT GTTCTAACTG TTTCACCTGA GGTACCAGGA ATGGTGACCT 42651 CTCTGGTCAC TAGTTCTAGA GCAGTAACCA GTACAACTAT TCCAACTCTG 42701 ACTATTTCTT CTGATGAACC AGAGACCACA ACTTCATTGG TCACCCATTC 42751 TGAGGCAAAG ATGATTTCAG CCATTCCAAC TTTAGCTGTC TCCCCTACTG 42801 TACAAGGGCT GGTGACTTCA CTGGTCACTA GTTCTGGGTC AGAGACCAGT 42851 GCGTTTTCAA ATCTAACTGT TGCCTCAAGT CAACCAGAGA CCATAGACTC 42901 ATGGGTCGCT CATCCTGGGA CAGAAGCAAG TTCTGTTGTT CCAACTTTGA 42951 CTGTCTCCAC TGGTGAGCCG TTTACAAATA TCTCATTGGT CACCCATCCT 43001 GCAGAGAGTA GCTCAACTCT TCCCAGGACA ACCTCAAGGT TTTCCCACAG 43051 TGAATTAGAC ACTATGCCTT CTACAGTCAC CAGTCCTGAG GCAGAATCCA 43101 GCTCAGCCAT TTCAACAACT ATTTCACCTG GTATACCAGG TGTGCTGACA 43151 TCACTGGTCA CTAGCTCTGG GAGAGACATC AGTGCAACTT TTCCAACAGT 43201 GCCTGAGTCC CCACATGAAT CAGAGGCAAC AGCCTCATGG GTTACTCATC 43251 CTGCAGTCAC CAGCACAACA GTTCCCAGGA CAACCCCTAA TTATTCTCAT 43301 AGTGAACCAG ACACCACACC ATCAATAGCC ACCAGTCCTG GGGCAGAAGC 43351 CACTTCAGAT TTTCCAACAA TAACTGTCTC ACCTGATGTA CCAGATATGG 43401 TAACCTCACA GGTCACTAGT TCTGGGACAG ACACCAGTAT AACTATTCCA 43451 ACTCTGACTC TTTCTTCTGG TGAGCCAGAG ACCACAACCT CATTTATCAC 43501 CTATTCTGAG ACACACACAA GTTCAGCCAT TCCAACTCTC CCTGTCTCCC 43551 CTGGTGCATC AAAGATGCTG ACCTCACTGG TCATCAGTTC TGGGACAGAC 43601 AGCACTACAA CTTTCCCAAC ACTGACGGAG ACCCCATATG AACCAGAGAC 43651 AACAGCCATA CAGCTCATTC ATCCTGCAGA GACCAACACA ATGGTTCCCA 43701 GGACAACTCC CAAGTTTTCC CATAGTAAGT CAGACACCAC ACTCCCAGTA 43751 GCCATCACCA GTCCTGGGCC AGAAGCCAGT TCAGCTGTTT CAACGACAAC 43801 TATCTCACCT GATATGTCAG ATCTGGTGAC CTCACTGGTC CCTAGTTCTG 43851 GGACAGACAC CAGTACAACC TTCCCAACAT TGAGTGAGAC CCCATATGAA 43901 CCAGAGACTA CAGCCACGTG GCTCACTCAT CCTGCAGAAA CCAGCACAAC 43951 GGTTTCTGGG ACAATTCCCA ACTTTTCCCA TAGGGGATCA GACACTGCAC 44001 CCTCAATGGT CACCAGTCCT GGAGTAGACA CGAGGTCAGG TGTTCCAACT 44051 ACAACCATCC CACCCAGTAT ACCAGGGGTA GTGACCTCAC AGGTCACTAG 44101 TTCTGCAACA GACACTAGTA CAGCTATTCC AACTTTGACT CCTTCTCCTG 44151 GTGAACCAGA GACCACAGCC TCATCAGCTA CCCATCCTGG GACACAGACT 44201 GGCTTCACTG TTCCAATTCG GACTGTTCCC TCTAGTGAGC CAGATACAAT 44251 GGCTTCCTGG GTCACTCATC CTCCACAGAC CAGCACACCT GTTTCCAGAA 44301 CAACCTCCAG TTTTTCCCAT AGTAGTCCAG ATGCCACACC TGTAATGGCC 44351 ACCAGTCCTA GGACAGAAGC CAGTTCAGCT GTACTGACAA CAATCTCACC 44401 TGGTGCACCA GAGATGGTGA CTTCACAGAT CACTAGTTCT GGGGCAGCAA 44451 CCAGTACAAC TGTTCCAACT TTGACTCATT CTCCTGGTAT GCCAGAGACC 44501 ACAGCCTTAT TGAGCACCCA TCCCAGAACA GAGACAAGTA AAACATTTCC 44551 TGCTTCAACT GTGTTTCCTC AAGTATCAGA GACCACAGCC TCACTCACCA 44601 TTAGACCTGG TGCAGAGACT AGCACAGCTC TCCCAACTCA GACAACATCC 44651 TCTCTCTTCA CCCTACTTGT AACTGGAACC AGCAGAGTTG ATCTAAGTCC 44701 AACTGCTTCA CCTGGTGTTT CTGCAAAAAC AGCCCCACTT TCCACCCATC 44751 CAGGGACAGA AACCAGCACA ATGATTCCAA CTTCAACTCT TTCCCTTGGT 44801 TTACTAGAGA CTACAGGCTT ACTGGCCACC AGCTCTTCAG CAGAGACCAG 44851 CACGAGTACT CTAACTCTGA CTGTTTCCCC TGCTGTCTCT GGGCTTTCCA 44901 GTGCCTCTAT AACAACTGAT AAGCCCCAAA CTGTGACCTC CTGGAACACA 44951 GAAACCTCAC CATCTGTAAC TTCAGTTGGA CCCCCAGAAT TTTCCAGGAC 45001 TGTCACAGGC ACCACTATGA CCTTGATACC ATCAGAGATG CCAACACCAC 45051 CTAAAACCAG TCATGGAGAA GGAGTGAGTC CAACCACTAT CTTGAGAACT 45101 ACAATGGTTG AAGCCACTAA TTTAGCTACC ACAGGTTCCA GTCCCACTGT 45151 GGCCAAGACA ACAACCACCT TCAATACACT GGCTGGAAGC CTCTTTACTC 45201 CTCTGACCAC ACCTGGGATG TCCACCTTGG CCTCTGAGAG TGTGACCTCA 45251 AGAACAAGTA AGAATAACTT TTTTATTGTG GTAAAATATA AATACTATAA 45301 AAATTGCCAT TCTAAACATT TTAATTGTAC AACTCAGCAG TACTAATACA 45351 TTCACATTGT TGTGCAACCC TCACCACTAT CTGTTTTCAA AACTTTTTTT 45401 ATCACCCCAA ACAGGACTGA AGGAATAATT TCCCATTCCC CATTCTCCCT 45451 AGTGCAGTGG TGCAATCTCG GCTCACCACA ACCTCTGAAC CTCTGTCTCC 45501 TGGGTTCAAG CAATTCTCCT GCATCAGCCT CCTGAGTAGT TGGGACTACA 45551 GGTGCACGCC ACCGTGCCTG GCTAATTTTT GTATTTTTAG TACAGACAGG 45601 GTTTTACCAT GTTGGTCAGG CTGGTCTCAA ACTCCTGACC TCAGGTGGTC 45651 CACACGCCTT GGCCTCCCAA AGTGCTGGGA TTACAAGTGT GAGACACTGT 45701 GCCCGGCCAT ATCTGTTAGA TCTTACTAAT CCTGTCAAGA GGATTCAGTG 45751 TCCTTTTTTT TTTTTCTTTC TTTTTTTTGA TAGAGTCTCC CTCTGGCACC 45801 CAGGCTGGAG TGCAGTGGTA CGGTCTTGGC TCACTGCAGC CTCCACCTCC 45851 CAGACTGAAG CGATTCTCCT GCCTCAGCCT CCCGAATAGC TGGGACTACA 45901 GGCGCGTGCC ACCACGCCCA GCTAATTTTT GCATTTTTAG TAGAGATGGG 45951 ATTTCACTAT GTTGGCCAGG CTGGTCTCAA ACTCCTGATC TCAAGTGATC 46001 CGCCCAAGGG CCTCCCAAAG TACTGGGATT ACAGGTAGGA GCCACCTCAC 46051 CTGGCCCTAT TTTCGGAATG GATTTTTTTT TAATGTTTAA AATGTCACCT 46101 AAGATTATTG TGAAGATCAA ATAAGATAAA ATCCTAATAA CCCAAGTAAA 46151 CCACAGGGCT CCACTTGGAC CAGTCTCAGA AGTTTCAAGA AAATCAGTCA 46201 GACCATCAAA TGTAAAATAA GTCTAAATTT TCTTTGCACT ATTCACAGAG 46251 TGCCAAAGAG GATCTAATTC ATGTTTCAGA ACATACCCTA CTTACTAAAA 46301 TCCCCTTTTC CTCATTTCTT CTCATTCTGC AACTTTATCA TCTCCTGCGG 46351 ACCCCCTAGC CTCTCCCCTC CCCATAGTCA GTCTCTCTCT CTCTCTTTCC 46401 CTCCCCTCTT ATTATCTCAA TTTCACACGA AAGAATTCCA GAAACTATAC 46451 TGCCAAAAGT CTTTCCTGTC TTTGAAAAGT TGGGAAAGAG GAGAAACTCA 46501 GACAGCAATG ACAAAATTAT ACGTAATGGA TGAAGGAAAC ACAAATAAGG 46551 CTGGAAACAG AAAATTTTGT CCCCATCATT TATTTAATGA AGGTGGCAGT 46601 ATTCCAGCCA CATAGTGAAC CCCCACAATA AGAAGGGGCC TCTGGCGATT 46651 GATTATTGTC ATTGTTGTTA ATGATAATGA GGGTGAGGAT ATCATGAGCA 46701 TCAGTGTAGG AGGCAGTTAA CTAATAAGAC CAAGCTGTTG GCTGGGCGTG 46751 CTGGTTCACA CCTGCAGTCC CAGCACTTTG GGAGGCCAAA GTGGGTGGAT 46801 CACTTGAGGT CAGGAGTTCA AGACTAGCCT GGCCAACATG GTGAAACCTG 46851 GTCTCTACCA AAAATACAAA AATTAGTCAG GTGTGGTGGC GTGTGCCTGT 46901 AATGACAACT ACTTGGGAGG CTGAGGCAGG AGAATCACTT GAACCTGGGA 46951 GGCGGAGGCT GCAGTGAGAT GAGCTTGAAC CACTGCACTC CAGCCCGGGC 47001 AACAGAGAGA GACTCTTGTC TCAAAAAACA AAACAAACAA ACAAAAACTA 47051 AACCAAACAA AAPAAGACTA GCTGTTATTC ATTTATTTAT TTATTTATTT 47101 AGAGACGGAG TCTCGCTCTG TCACCCAGGC TGGAGTGCAG CGGCACAATC 47151 TTGGCTCACT GCAACCTCTG CCTCCCAGGT TCATGTGATT CTCCCGCCTC 47201 AGCCTCCCCA GCTGTTGTTA TTCATGAATG AACCTCAGAG AAAGCACACA 47251 GGAGGGTTGG TGCACCTGTG TTTTGAGTTC TACCCCTCCT TCCTCTCTTA 47301 ACTTCCTCCT GTCTTCTCAC TCTGATTCGT TCTTCCTTCC TCTCCCTCTC Exon 7 47351 TCTCTGCAGG TTATAACCAT CGGTCCTGGA TCTCCACCAC CAGCAGTGAG 47401 TAAACATGGC CCTGAAGTCC CTATGCCCTG GGAATTCTTC CTCCCTAAGC 47451 CTGCCTTCCA GGAGGAAAGT ATCCCCCATT CCCTAGGTTC TCATCCCCAC 47501 AGAAACTCCA GAATAGCAAA AGTCTCAGGC TGAGCCAAGG CACAGATGCC 47551 AGTGCTCACC AAGAGTCCTA TTCTCCCCTC GCTAAATGAT AGGACCCAAC 47601 AAACCCGATT CACGCTGCGT TTTCTTTCAG CTCCGATGAC CTCCATGTTC 47651 TCTCCAAGGC CTCTCGTATC TGTGAGCCCC ACCCCCAGCG CTACAGGTAG 47701 GAATCTGGCT TCCAGCTCCC ATGAAACGTC GGCTGCCATT CAGTGGCTGA 47751 TTAATTGCTG TGTGGTCTGA GTCCTGATGC CCACCAAGTC TCAGCGTGTT 47801 CCCCTCTGTC CAATCTCATC CAACAATTTA AGCTAATGCT TGTTTAATGA 47851 TGTCCTCACT ATACCACCTT GGACACTTTC TTTTTGCCTG GATTTAAAGC 47901 TTCCATTTCT TTCCTTCCTT CCTTCTTTTC TTCCTTCCTT CCTTCCTTCC 47951 TTCCTTCCTT CCTTCCTTCC TTCCTTCCTT CCTTCCTTCC TCCTTCCTTC 48001 CTTCCTTTCT TCCTTTCTTC CTGTCTTTTT CTTTCTTTCC TTCTTTTGGC 48051 AGAGTCTCAC TCTGTCGCCC AGGCTGGAGT GCAATGGTGC AATCTCGGTT 48101 CACTGCAACC TCTGCCTCCC AGGTTCAAGC GATTCTCATG CCACATGCCA 48151 CTATGCCTGG CTAATTTTTG TTTTTTTGTT TTTTGGGGGG TTTTTTGAGA 48201 CAGAGTCTCA GTCTGTTGCC CAAGCTGGAG TGCAGTGGCA TGATCTCGGG 48251 TCACTGCAAC CTCCTTCTCC CAGGTTCAAG CGATTTTCCT GCCTCAGCCT 48301 CCTGAGTAGC TGGAACTACA GGCACGCACC ATCACACCGG CTAATTTTTT 48351 GTGTTTTTAG TAGAGACGAC GGTTTTGCAA TGTGGGCCAG GCTTGTCTCG 48401 AACTCCTGAC CTCAAGTGAT CCTCCAGCCT CGGCCTCTCA AAGTGCTGGG 48451 ATTACAAGTG TGAGCCACTG CACCAGGCCA AAAACTTGTA TTTCAATAGT 48501 CATTGAGGCT GGGTGCAGTG GCTCACGCCT GTAATCCCAG CACTTTGGGA 48551 GGCTGAGGCC AGTGGATCAT GAGGTCAGGA GATCAAGACC ACCCTGGCTA 48601 ACACAGTGAA ACCCCATCTC TACTAAAAAT ACACACAAAA ATTAGCCGGG 48651 CATGGTGGCA AGATGCCTGT AGTCCCAGCT ACTCAGGAGG CTGAGGCAGG 48701 AGAATGGCGT GAACCTGGGA GGCAGAGCTT GCAGTGAGCG GAGATCGCAC 48751 CGCTGCACTC CAGCCTGGGC AACAGAGAGC GACTCTGTCT CAAAAAAAAA 48801 AATATATATA TATATATATA TATATTCATT GAGACCGACT CTGACTTAAA 48851 AGCAGTAATG AATGGTGTAG GTTTTGGTAA ATTACAGGTC TTGCTTTAAG 48901 TCCTGGTCCT CTCTTTTGCT CACTGTGTGG CCCCGGAAGA GCCATGTAAC 48951 CTCTCCAGGC TTCAGTGTCC ATTTTTAGAA CGGAGTAAGT GAATAAGCTG 49001 TGTCCAATCA TCTCTGGCCA TATCAGCTTC ATTTTTTTTT TCCTCCAGGG 49051 TCCAAACATC CCTCCACCCT CAGAGTCTTT GCACCTGGTG TTCTTGTCCT 49101 TCAAATCTCA GCTTGGATCA CCCTTTATAA AGTAGCATTT CCCCCGTATA 49151 CGCATCTTGC ACACAGCCAA TCTCTATTCT ACCTCTATGC TCACTTCCTT 49201 CCTGGCAATT ATTACTACAG CTGGGCCCTT GAACAGCATG AGGGTTCAGG 49251 GTGCTGACCC CTATGCATTC AAAAATCCAC ATATAACTTT TTTTTTTTTG 49301 AGATGGAGTT TCACACTTGT TGCCCAGGCT GGAGTGCAGT GGCGCCATCT 49351 TGGCTCACTG CAAACTCTGC CTCCTGGGTT CAAGTGATTC TCCTGCCTCA 49401 GCCTCCTGAG TAGCTGGGAT TACAGGCATG TGCCACCATG CCCAGCTAAT 49451 TTTGTATTTT TAGTAGAGAT GAGGTTTCTC CATGTTCGCC AGGCTGCTCT 49501 TGAACTCCTG ACTTCAGGTG ATCCGCCTGC CTTGGCCTCC CAAAGTGCTG 49551 GGATTACAGG CATGAGCCAT GATGCCCGGC CATTTGCTAA TGGCATCTAG 49601 TAAGTAGAGG CCAGAGATGT TGCAAAACAT CCAACAATGC ACAAAGCAGC 49651 CTCCTATCAA AACACATTAT CCAGACCAAA ATGTCAATAG GGCTGAGGTT 49701 GAGCATCTGC TGTACACAGA TTCCAAGTTC TGGTACAAAT CTCGTAGTTC 49751 TCTGAGGGCT CATCTTTCAA TGCCTAGCAC ATCAAAGGAG GCCAATTTCC 49801 TCTTCCCTTT CACCTCCTGG TATGAAATGT TTCCTCCTCC ACCTTGATCC 49851 TGTAAGAGCC CAGCTGGAGT TTGCAGACGA CGGGGAAAGA AATGGGTGAG 49901 GGAGGGTCCT ATGGTTGAGT CTCCOCAGTG GGCCCTGGGT GCCCAGTTCA 49951 CCCTCCTCCC CTTCATTTTC TCCATCATGA CAACTCAAGG CAAATTCTCA 50001 GTTTCCATGG GCCAGTGGAA TCCACTGACT TCATGAAATA ACCCCACCCT 50051 GAGCAAATAC CCCTCAAATA ATAACTGTTT ACACAACATC AGTGGCAACA 50101 ATGACCCAAG CAGCAATGCC ACCACCAGAA TAGCAACCAT AACAGCAGCT 50151 CATTTTCATC AAAAGGAAAC TGTAGGGCCA GGCACAGTGG CTCACACCTA 50201 TATTCCCAGC ATTTTGGGAG GCTGAGGCAG GCAGATCACC TGAGGTCAGG 50251 AGTTCAAGAC CAGCCCAGCC AACATGGTGA AACCCCATCT CTACTAAAAA 50301 TACAAAAACT AGCCAGGCTT GGTGGCATGT GCCTGTAATC CTAGCTACTC 50351 GGGAGGCTGA GGCAGGAGAA TTGCTTGAAC CTGGGAGGCA GAGGTTGCAG 50401 TGAGCTGAGA TTGTGCCACT GCACTCCAGC CTGGGCGACA GAGCAAGACT 50451 CCGTCTGAAA AAAAAAAAAA AAGGAATTGT GCCAGGAATT GTGATGAGAA 50501 CTTTATATGC ATTATCTCCT ATTAATATTA CCCAAACCTC CGTGAGTTAG 50551 TATACTCATT TCTACAGAGA GCATTTATGC ATCCAGGGAG GAAGTAATTA 50601 GCCCAGAATT ACTCAGTTAT GACACAGGAC AGTATGAAAA CTCCAACCGA 50651 AGATTGGAGA CTCATGAAAA CTCCAGGCTC CTAACTACAA GACATCACTG 50701 TGGATCGTCC AAATAGAGCA AGCCCCAATC TCAGGACAGG AATGAGGCAT 50751 GAATGGCCTC TATGCTAATG ATCTAACCTA ATGCTGAATT TGTTACTTCC 50801 CTTCTGAATC CACTTGGAGA TTTCCTTTAT ATCTGACTTG AAATAGAGGA 50851 TATATACTCC TCTATCCTTG ACATAGGAGA TAATACACAG AAAGTATTTC 50901 ATTGTAGTAT CAAGTACACA TCCTGTTCTG TGTCCATAGG ATTATGACTA 50951 ATTTAGGGCA TGGCTTAACA GTGTGGTACT ATTGAATGAC AGACAGATGT 51001 CTGTTTTGTT GGATGCAGGA CAAGCCATGT AACCTCCCCA GACTTTAGTG 51051 TCCCCTCTGT GGAATGGAAT AAAAATACTA CGTGGGATTG TTCTGATAAT 51101 CAAATGAGAT AATTCAGGAA CAACCCAGAT AAATAACAGG GCTGCCCTGG 51151 GTTCTGTCTT TCCTTGTATC TCTCACAGAG CCTCAAAGGA GATGCAATCC 51201 ATGACCTAGA GAAACACTCA GGACAAATTC TCTTTTCCCC AGTTCCTTTC 51251 TTGCTCCAAT GGCAACACCA CCCCTCTCAT CCTGAAGTCT CTTGTTTTTA 51301 CCACCACACC TATTTTGCCA AATTTTCTCC AATATTCCAA ACCATATGAA 51351 ACCTTTCTTT CTTTCTTTTC TTTCCTTCCT TTCCTTCTTT CTTTCTTTTT 51401 TCTCTTCTTT TCTTTTCTTT TTGAGACATG GTCTCACTCT GTTGCACAGG 51451 CTGGAGTGCA ATGGCACGAT CTTTGCTCAC TGCAACCTCC GCCTCCCAGG 51501 TTCAAGAGAT TCTCTTGCCT CAGCCTCCTG AGTAGCTGGG ATTACAGGCG 51551 CCCACCGCCA CGCCACGCTA ATTTTTGTGT TCTTAGTGGA GACGGGGTTT 51601 CGCCATGTTG GCCAGGCTGG TCTTGAACTC CTGACCTCAA GTGATTTGCC 51651 CATCTCGGTC TCCCAAAGTG CTAGGATTAC AGGCGTGAGC CACCAAGCCC 51701 GGCCCCATAT GAACCGTTTC TATCCCTCAT TTCTCTGTAC TTTTACCTAA 51751 AAACACCACT CCCTTCACCC ATCACATTTT TGTCAATTCT ACATCACACA 51801 CACACACACA CACACACACA CACACACAGA GAAAGTAAGT TGGAAAAAAA 51851 TTATACTATC ATGAAATTTT GTGAAAGGAG GTAAGCTGAG AGAGTAAGAA 51901 TCAAACTAAA TTATCTTTAT GGGTAGAAAG CACACTCATC CATACATGTG 51951 TCTTTCCACC CTTGTAATGT ATTTATTATT ATTGTTTGTA TATACTAGAT 52001 TCCCAATAAA TAGGGACAGC TATTATGGTA TTTTTATTTC AGGAATAATA 52051 ATAGTGATGA TTTCCACCAT TATTGTCAAA GGACAAAGCA CAAAATATGT 52101 ACCAAATAAA ATATAGCCAT TATCCTTTAT TCACAAAAGA TCTTGGCCCC 52151 ACCTCTTCTC AATGAAATGT CCATGACTTG TTCAACTTTG GCCACTCTGG 52201 GCTGAGAGAT GGAGGTTCCC TTGCGAGCTG AAGTCACACA TCGAAGGTGG 52251 AAGCCCCTCC CCTCCCTCTG GCTGGCTGAG GGATAGCCCA GATGGGCTCA 52301 TCATGAAAGT TTCCCATTAT TTCCATTTCT GGATCTACCA TCTTCCCCTC 52351 CCCTACCTCT CACCCATCAT AATTGTCCTT CTTTACTCTT TCCTCCCTAT Exon 8 52401 CTGCAGGTTA TAACCGTCGG TACTGGACCC CTGCCACCAG CAGTGAGTAT 52451 TCAAACCTGT GATATTCCAA TGCCCTTGGG ACCCTTCCTC CCCAAGGTGC 52501 ATTCCTCAGA AGAGAAACTG ATCATTCTCC CTCCCTACGT GCCCAGCCAC 52551 AGCCTCAGAG CAGCCCCTAA CCCGTCAAGG TCTTGGTGTG AGTCAAGATA 52601 GAAGTCCAAA TTCCAATGAG CAGTTCCTGT CCCATATTCC TTTAGGAAGA Exon 9 52651 CACCCAATCA TTTCTCCATG TTCTTTTTTT CTCAGCTCCA GTGACTTCTA 52701 CATTCTCCCC AGGGATTTCC ACATCCTCCA TCCCCAGCTC CACAGGTAGG 52751 AAGCTCCTCT CTGGCATCTA TGAAATTTAA CACTGCATGG TCTGTTCCCT 52801 GCTGACCACC CAGACTCAGC CTGTTCCACT CGCCCTCTCA CTCTCTCTCT 52851 CTCTCTTTTT TTTTTTTTTT TTTTTTTTTT TTTACGGAGT CTTGCTCTGT 52901 CACCCAGGCT GGAGTGGAAT GGTGTGATCT CGGCTCACTG CAACCTTCGC 52951 CTCCCAGGTT CACGTGATTC TCCTGCCTCA GCCTCCGGAG TAGCTGGGAT 53001 TACAGGTGCA CACCACCATG CCTGGCTAAT TTTTTGTATT TTTAGTAGAG 53051 ACGGGGTTTC ACCATGTTGG CCAGGCTGGT CTTGAACTCC TGACCTCAAG 53101 TGATCTACCC ACCTTGGCCT CCCAAAGTGC TGGGATTATA GGCATGAGCC 53151 ACCACGCCAG GCCCACTCTC TAAATTTTGA CCACCCTGCC TTGAGTGGTC 53201 TTCTAGCACC CTAACCTCTG TCTAACCTCG AGAGCTTTGC ACTAGCGATT 53251 CCTGGGGACC AGCTATGGTT GGTATCTTCT CAACTTTCTA ATTTTTTTAA 53301 AATTATTATT ATTATTATTA TTATTTTAAA TGGAGTCTCG CTCTGTCACC 53351 CAGGCTGGAG TGCAGTGGCA CCATCTCGGC TCATTGCAAC CTCTACCTCC 53401 CGGGTTCATG CAATTTTCCT GCCTCAGCCA GAAATTTTCT CAGTGGTCGA 53451 GATTGTGCCA CTGCACTCCA GCCTGGGCAA TGGAGCTAGG CTCCATCTCA 53501 AAAAAAAAAA AAAAAAGACG GAGGTCGGGC ATTCCTAACC CTTAACCCTG 53551 CCTTGTGATT CTGGAGTTAT GAGATAGAAC CTGGTGTCCC GTAATTAAAA 53601 TTCCGCCTTC AGGCCTTATG TTTTGTGAGT CACAACACTG CAAACTTTTT 53651 ACATGCTGTA GACAGGATGT TCACTCTCCA CTTCCTCACT GCTCTGCTCT 53701 AATCAATTCA ACCATTTATG TGACATGCCT AACCCCTCTG GGCTTGTACG 53751 TATGTAACAT GTATTACAAA GCAAGTCATT CCATGATCAA TGCTGTCACT 53801 TTTTCTAGGT GCTTTCAAAA TTTGTTCTTC ATCATTGATT TTCAGTAGTT 53851 TGATTACGAT GTGTCTGGGC ATGGTTTTCT TTGAGTTTAT CCTGCTTAAA 53901 GTGTTCTCAG CTTCTTGAGT CTCAAAGTGT TTATTTTCTG CTCTGATTCT 53951 TTCTCCCCTT CGGACCTCCA ATGPAATGAT GTTGCCCGAA GAGACCCTGA 54001 GGTTCTGTTC ATTTTGTTAT TTATCAATCT TTTTTCCTCT CCGAATTTCA 54051 GGTTTAATAA TTTTTTTTTT TTTTTTGAGA CGGAGTCTCG CTCTGTCGCC 54101 CAGGCTGGAG TGCAGTGGCG CGATCTCGGC TCACCGCAAG CTCCGCCCCC 54151 TGGGTTCACG CCATTCTCCT GCCTCAGCCT CCGGAGTAGC TGGGATTACA 54201 GGCACCCGCC ACCATGCCCG GCTAATTTTT TGTATTTTTT AGTAGAGACG 54251 GGGTTTCACC GTATTAGCCA GGATGGTCTC AATCTCCTGA CCTCGTGATC 54301 CGCCCGCCTC AGCCTCCTAA AGAGCTGGGA TTACAGGCGT GAGCCACTGC 54351 GCCCGGCCCA GGTTTAATAA TTTTTATAGA ATATTTTCAC AATCACCAAG 54401 CCTTTTCTCT ACCAGCTCCA TTCTGCCCAT CCATTGAATT CTTTTTATCT 54451 CAGTTACTTT ATGTTTCAGT TCGAAAGTTT CTACTTGGTT AGATAGATAG 54501 ATGTTATATC ATATATTATA TGTTATATAA AAATATATTT ATGGTTATAC 54551 ATATAACATA TATGTTATAT ATAGTTATTT ATATAGCCAT AACTATATAT 54601 AGCCATATAT ATAGTTATAT ATAACCATAT ATATAGTTAC CATATAGTAA 54651 CCACATATAT AAAACATATA TATATAGTGT CTCTCTATAT ATAGTTATAT 54701 ATATAGTTTC TATATCTGTA ACTATATATA GTTATATATG TATGTTTCTC 54751 TGTATATAAA TATATATATT TCTATATATA TAGTTATACA CATTATATAT 54801 ATAACTGGGA GATGTTGGTA AAGGATGGCG TGAGGAAACC TGGAGCAGTC 54851 ATGGTAATCC TCGCTCTGCT CCGAACTCCT CAAGAGCAGG AGAAGGGTCC 54901 TCCTCATTCT CCAGCCATGT TGACTTTGAG CAATTTACTC ATCCTCTCAG 54951 TACCTCAGTT TCCTCACCTG CCAATTGAGG ATAATAATAT TTCATAAATT 55001 GTTTGCAAAT GTTATATGCA ACTCTACGTA AGAACACCTA GCACAGGGGC 55051 TACCAGGGAA TTTGGTTTAA CAAATATTTA TCAGGCACCT ATTCTGGGCT 55101 GGGCAGGGGG GATAAGATGT TGACTAAGTC AAATGCAGTC CCTCCCCTCA 55151 CCAAGTTTAC AGTGTATTGG GCAAGACTGA AATGGAACAA GCAATTACAA 55201 TTGACAATAA AAGACAACCA AGTTATTGAG CACTTACTAT ATGGCATGCC 55251 ATATGCTATG TATTTTTTTT ATTTTTAACT TTTCATTTTG AAATAAATAA 55301 TAAATATAAA GTAAATAATA ATATAAATAA ATAATAAATA ACTTTTCATT 55351 TTGAAATAAA TAATAAATAA ATTCAGGAGA TGTTGCGAAA ATAGTGTAGC 55401 ATTCCCCTGT ATCCTTCACC CAGTTTCTCC CCAATGGCTA CATCTTACAT 55451 AACTCTAATA CAATATCAAA AGCAGGAAAC TGACATTGTT AAAATCCATT 55501 TTACTGGTTT TACACGCGTG TGTGCATATG TGAGCTTGTG TATGTGCGTG 55551 TGTGTGCAGG CATGTGTGTG CATGCACGCC TGTGTGTGCA TATGTGCATG 55601 TGTGCATGCG TGTGTGCATG TGTGCATGTG TGTGTGCATG CGTGCGTGCG 55651 TGCGTGCATC TGTGTGCATG TATGCACATG TGTGTGTGTC TGTGCACGTG 55701 TGTGCATGCA TGTGTGTGTG CGTGTGTGTT GGTAGCCCTA TGCAATTTTT 55751 ATCACATGGG CATAGCCCTA TAATCACCAC CACCATCAAG ATTCAGAACT 55801 GTTCCATTCC CCCAAAGATT CCCCTCATGC TAGCCTTCGT AATCATGCCC 55851 ACTGAGCCCA ACACTATTGC ATAGAATAGC TATTCTACTC TCCATCTCCA 55901 TCTCTGTCTC TACAATTTTC TTTTGAAGAT GTTATATAAA TGGAAATGTA 55951 CAACATGTCA CCTTTGAAAT TGGCTTCTTT TCCACTCAGT GTAATGCCCT 56001 GGAGATGTGC TCTTTTTAAC AGTCATGTAA CCTTCCTAAT TTCCCTCCAA 56051 AATATCATTA TGCCCCTCGC CGCCTTTTTT TTTTTTTTTT TTTTTTGAGA 56101 CAGAGTCTCG CTCTGTTGCC CAGGCTGGAG TGCAGTGGTA TAATCTCAGC 56151 TCACTGCAGC CTCCGTCTCC CGGGTTCAAG GGATTCCCCT GCCTCAGCCT 56201 CCCAAGTAGC CAGGATTACA AGTGCATGCC ACCACGCCTG GCTAATTTTT 56251 GTATTTTTAG TCGAGACGGG GTTTCATTGT GTTGGCCAGG CTGGTCTCGA 56301 ATTCCTGACC TCAAGTGATC TGCCCGCCTT GGCCTCCCAA AGTGCTGGGA 56351 TTACAGGTGT GAGCCACCGC GCCCGACCCA TATTGCCCAT TGTATTACAG 56401 CGGAAGAAAC TGAGGTATGG ACAGGTAACA TGTCCATGGT CACTTGGCTG 56451 GTGAGGGGCA GAGAGGAGAT TTGAAACCAA ATCTGACTCA CTAGTGTGGC 56501 CGTAACCATG GTAACTATGT CTCTCTACCA TGTGGTCTCC TCTTTATTAA 56551 AGGAAGGGCA AGTTCTGGGA GTTTTGGGAG TTTTGGGCTT GAGTGGGGAA 56601 GGGTAGCCAA GTAAAGCAGG TGAGAGAAGG TCTGCTTTAA GGACTGCTGT 56651 TTGATTTTTA TTGTTGTTGT TCAGTGTTCA ATGGGATTGA GTTGACTCTT 56701 TTTTCCCTTC TTGTTCCCCA AAGCATGAGA CTGTTCCGGT CCTTTTCCCT 56751 TTTAACTTCT CAGCTAGAGT TTGTTAGGGC GGGTATGGGC ACCTGGCAGA 56801 GTCTGAGACC TCAGCTTCCA GTAGGCACAC GTTCTGACCC AATACACCTA 56851 CCCTGGTCCC CTAACCTGCT TCTGGTCCCC TAACCTGCTT CTGGGCCCAG 56901 GTAATGCATT TTAGGAACAT CCCACTTTTC TCCTTACCTG GCTTTCCATT 56951 ATCCGTCCAA ACTAAAGCAC CCACCTGTCT GCTTCAGACT CTTGCTTCAA 57001 GCACTCCGTC TGGGTCCTCA GAAATTGACT TACAGTCAGT TCAGATCTGA 57051 CTCAGGCGTG GCCTTCTTTT CTCCTTCCTT GC

[0054] 2 TABLE 2 Genomic Repeats (SEQ ID NO: 2) Exon R1   1 AGCAGCCACA GTCCCATTCA TGGTGCCATT CACCCTCAAC TTCACCATCA   51 CCAACCTGCA GTACGAGGAG GACATGCGGC ACCCTGGTTC CAGGAAGTTC  101 AACGCCACAG AGAGAGAACT GCAGGGTCTG GTGAGAGCCC CGCCCACCGT  151 ACTCCTCCCT CGCCCACTTA GACAAACCAG CCCACCTCAC ACTGCCTCGC  201 CCACTGATGC CAGCCACGCC CACCTCATCC AACCCCAGAC ACCTTTCCCT  251 GCCCCACCCA CTGATTTTAG CCAAGCCCAC CTCACCCCAC CCAGCCTACT  301 GATGCCAGCC ACGCCCACCT TTCCCTGCCC CGCCCACTGA TTTCAGCCAC  351 GCCCACCTCA CCCTGGTCCA CCCCTCCAAT GCCCCACTCT TCCTGGCTTC Exon R2  401 CCGCAGCTGT TGTTTCTCAC CTCCCCTCTC CTTCCTTGCA GCTCAAACCC  451 TTGTTCAGGA ATAGCAGTCT GGAATACCTC TATTCAGGCT GCAGACTAGC  501 CTCACTCAGG TGAGACGCTC CTTAAGAAAA ACACAGCCCA ACAGGTGAAT  551 ATGACCCTAG TCTCTGGGCT CCCTGACTCT GTTCATACTT GGAACAACTA  601 TTGCCCATGG ATACTAAGCA TCACCACCAG CAGCAGCAGA TAACTATTCC  651 TAAGACCCAA GGCACTGCAT TATGTACTTT ATATTTAATG CCTCATCAGT  701 GCTTGCAACA GCCTCATGAA GCAGGAGCAG AAGGGGAAAC TGAGGCCCAG  751 ATTAAGTGGC TTGTGCCAGG ACACACAAAG CAACTGCAGC ACTTCAGGTT  801 CTATATCCAA ACTCCTATCC CTTAGGTGGC ACTTCCTCCT CTGCCCCCAT  851 TATGAACTTG CAGCATGTGG AAAACCCCAA TCTGACTTCC CTCTAAGGGA  901 ACTTGCCCAG AGAATCTAAG AGGGGAGGAA AGGAAGGCGT TCAGCCCTTA  951 CAGGCAGGAG GTCAGCTCCT GAGTGGCTCA GATGCAGCCA CAGAGGGCCT  1001 GGCCGGTCTG AGGGTGACTG AGAGGCACCG AGGGCACTGT CCCTGAGTGC  1051 TGGAAAGGGC AGGTCTTTTA GGGTAGACAG CGGTTGATAT CATTTCCTGC  1101 CTGGCATTCT CACCTTCCAC ACCTCTCTCA CAGAATCTCC AAGTGTGGCT  1151 CTCCCAAGAG AGAGTGTCAG TCATCTACCT CCAGCTTCCT TTCCTTCCCA  1201 GGGGGAAGAG GGGACAGGGG GGCCCTAGTG GCTAAGAGCA TTGGTGAACT  1251 CAGGCAGACC TCAGTTCTGA ACCAACCCAG CTCTGCCATT TACTATCTGT  1301 GACTCTGAGC AAGTGCCTGA AGCCTTCTGT GCCCTATTTC CTGACATATT  1351 ATATATATAA AATACATATA TTATATATAG ACATATTTTA TATACATATT  1401 GAGGCATATT TTATAAACAT GTTTATAGAC ACATTTTTAT ATGCATATGT  1451 TATATACGTA TATAACATAT GTTATATATA ATGTATATAT TATACATATT  1501 GTTATATTGT ATACATGTTA TATATGTTAT AGCATATATA GTACAAGTTA  1551 TATATAACAC ATACATTATG TTACATATAA TGTATATGTT ATATATGATA  1601 TATTATATAT AATTATATAT TATATAAAAC TGTTATATAT AATTATATAT  1651 AATATATAGT TGTTATATAT AATTATATAA TTGTTATATA TTATATACAA  1701 CATATAACAT ACATTATATA TTGTTATATA TAATATAATA TATACATATA  1751 TAACATATGT ATAACTTTTA TGTTATACAT AATGTATATA ACATATATGT  1801 GTATGTGTGA TGTACATAAC ATATCTGACA TTAACATATA ACATATGATA  1851 TAACAATATT ATATGTTATA ACATAATATA TGTTATAATA TAACAATATT  1901 ATATGTTATA ACTTATACTG TCATATGTAA CATATACATA ATATTTTATA  1951 AATCAGTTTA ATATACATTA TGTTACATAT AATGTATGTT ATATATGATA  2001 TATTATATAT AATTATATTA TACATAATTG TTATATATAA TGCATACATT  2051 GTATTTGTTA CGTATTATAT GCAACATATG GGGATCCTCT AGAGTCGGAC  2101 CAGCGGCAGC AGCTGCCTGC CTTTTNNNNN NNNNNNNNNN NNNNNNNNNN  2151 NNNNNNNNNN NNNNNMNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN  2201 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN  2251 ATATACATAC ATAACATATG TATAACTTAT ATGTTATATA TAAGTATATA  2301 ACATATATGT GTATGTGATG TATATAACAT ATCTGACATT AACATATAAC  2351 ATATGTTATA ATATGACATA TTATATATAT TACATATAAC GTATATCATG  2401 TATAATATAA TGTGTATATA TAATATATTA AAGTATATAA GTATAAATAC  2451 ATGTAATATT TAAATATATA TTATATATAG TATACATGTG GATACATACA  2501 ACTTCTACAT ATACCTAGTA TATATTCTAT ATATAAACAG TCCATGAATT  2551 ACAATGATTC AACTTATGAT TTTTCAAACT TTGTGATAAT GCCATAGCAA  2601 TATGCATTCA GTAGAAAGCA TACCTTCAAC ACCCATGCAA CCATTCTGTC  2651 ATTCACTTTC AGTACAATAT TCAATAAATT ATATGAGATA TTCAACAGTT  2701 TATTATAAAA TAGGCTTTGT GTTAGGTGAT TTTGCCCACA TGTAGGCTAA  2751 TGTAAGGGTT CAGAGCATGT TTAAGGTAGG ATAGGCTAAC CTATCATGTT  2801 CTGTAGGTTA GGTATAGTCG ATTTTTATTT TTATTTTTAT TTTTGAGACA  2851 GAGTCTTGCT CTGTCACCCA GACTGGAATG CACTGGTGCG ATCATAGCTC  2901 ACTGCAGCCT TGAACTCCTG GGCTCAAGTG ATCCTCCTAC CTCAGCCTCC  2951 TGAGTAGCTG GGACTACAGG TGTGTGCCAC CACACCTGGC TATTTTTTTT  3001 TTAATTTTTT TTTTTTTGTG GAGAGGAGGG TCTTGCCATG TTGCCCAGGT  3051 GGCCTTGAAC TCCTGGGCTC AAGGAATCCT CCCACCTTGG CCTCCCAAAA  3101 TCCTGGGATT ACAGGTGTGA GCCATCACGC CCGGCTACAG GGCATTTTTG  3151 ACTTATGACA TTTTCAGTTC ACAATGGATT TGTCAGGGCT GGGCATGATG  3201 GCTCACACCT GTCATCCCAG CACTTTGGGA GGCTGAGGCA GGTGGATCAC  3251 TTGAGGCCAG GAGTTTGAGA CCAGGCTGTC CAAATGGCAA AATCTTGTCT  3301 CTACTAAAAA TACAAAAATT AGCCAGGCGT GGTGTGACAA CTGTAGTTCC  3351 AGCTACTCGG GAGACTGAAG CGTGAGAATC ACTTGAACTT AGGAGATGGA  3401 AGTTACAGTG AGTCAAGATC ACACCACCGC ACTCCAGCCT GGATGACAGA  3451 GCAAGACTCT TGTCTCCAAA AAACAAAAAA CAGGCTGGGT GCATGGCTCA  3501 TGCCTGTAAT CCCAGCAGTT TGGGAAGCTG AGGCAGGTTT ATCACCTGAG  3551 GTCAGTAGTT CACGATCAGC TTGGCAAACA TGGAGAAAAC CCATCTCTAC  3601 TAAAAATACA AAAATTAGCT GGATGTGGTG GTGGGTACCT GTAGTCCCAG  3651 CTACTCGGGA GGCTGAGGCA GGAGAATGGA TTGAACCTGG GAGGCAGAGG  3701 TTGCAGTGAG CCAAGATCAC ACCATTGAAC TCCAGCCTGG GCAACAGAGT  3751 GAGACTCCAT CTCCAAAAAC AAAAGAAAGC AAAAACAAAA AAATAAAATA  3801 AAAAACCTGT GTTTATCAGG ACATAATACC ATCATGAGTC AAGAAGCATC  3851 TAAATGTACA TGGTAGTTAT ATAAAAATAG TTATATAGTT ATATACAATA  3901 GTTATATATA AACCAGTTTA ATATATGTTA AGTAGAGGTA TATGGTAGTT  3951 ATATAAAAAA TAGTTATATA ATAGTTATAG AGTTATATAA TTATATAAAA  4001 TAGTTATATA TAAACCAGTT TAATATATGT TAGGTAGAGG TATAATAATA  4051 TATATTGTAT ATACTATATA ATATAGTAAT GTATAAAATG CAAAACGATA  4101 TCATATATTT CTATATTAAG TTTATATTTA CAGATCTACA TTTTATATAT  4151 TTTATGTTAT ATACAATTGT GTTATACATA ATATAATTAG TATAGTACTG  4201 ACTTGGGGAA TTGAGCAGTA CCAACCCATA GGGATGTTTG AGGATGAAAA  4251 TATGTGATTA TGAATACAAA ATGCTGGGCC TGCTGCATAG GAAGTATTTA  4301 ATAAATGGTA GTTGTTACTA TAAAGTCGTT CCTACTATAG AGCTACTCAC  4351 AACCTGGGAC ATAGGGAAAG AGCCCGTTTC CCTCTAATCA CTCAATAGTG  4401 GGTGGCTAGG TAGGTGAGTC CACATCCTGT GGCCGGGAAC AGGTGCTGAG  4451 ACATGAAGAC CTTCTGACTG CATGTTGGAC CAGCCACAGT TTCAGACGGA  4501 CCAGCCAAAA AGGGCATTTT CCCCAAGCCA TTTAGCTCCC TTGAGTCTCA  4551 TAACAAATCT CCTAGACCCT GCTGGTCCAT AGGATCTAGA GAGGATGACT  4601 TGAACCTTCT GATCCCACCA TTTGAAAACG CCATGCCATG GGCACCAGTA  4651 GGAGGGCCAC TGCTACGTGC ACCAGTACAA GGGCCACTGC CATGGATTAC  4701 AGATTAACCC TAAGTATAGC TGTCGCACAC CTAGTACTTC AGGAGGCTTA  4751 TTCGGGGCCA TGCAGATCCC TGGCATTATT ATCCTAGGAT CCTACACCAA  4801 GCAAAGCAGG AGCTGCCCCT CCTCATAAAC CCATAAGCCC TCCTCTTGAG  4851 CAAAGCAGCT GGGAAGGCCA GAAGTTATTC AAGCTCCCCT CTGCCCCGGT  4901 TCCAAAGACA GACAGCTCAA GCCTACATGC AGCAAACCCT ATAAAAGTGT  4951 CACCTCTTGG CATTTCTGCC ATGGTAATGC TTTCTGCTTC CACTAATAAT  5001 CCTAGTAATT TGTTTATGGT GGGCATCTCT CTGATGAGAA CCACATTCTT  5051 TTTTTTTTTT TTTTTTTTTT TTGAGATAGA GTCTCACTCT GTTGCCCAGA  5101 CTGGAGTGCA GTGGCGCGAT CTCGGCTCAC TGTAACCTTT GGCTCCTAGG  5151 TTCAAGCAAT TCTCCTGCCT CAGCCTCCCA AGTAGCTGGG ACTGCAGGCA  5201 CGTACCACCA TGCCCAGCTA ATTTTTGTAT TTTTAGTTGA GACGGGGTTT  5251 CACCATGTTA GCCAGGATGG TCTCAATCTC TTGACCTCAT GATCCACCTG  5301 CCTTGGCCTC CCAAAGTGTT GGGATTACAG GCATGAGCCA CCATGCCTAG  5351 CCTGAGAGCC ACATTCTTGT TAACCACAAT TTTCTCAGAG TCTGCATTAG  5401 GGGTTGACAA AGAGTGGAAA GGAAGGACAA AAGGATGGAG AGGTGGATGG Exon R3  5451 ACTAAGCATA TGTAGGTTCT TACCCAGGCC AGAGAAGGAT AGCTCAGCCA  5501 CGGCAGTGGA TGCCATCTGC ACACATCGCC CTGACCCTGA AGACCTCGGA  5551 CTGGACAGAG AGCGACTGTA CTGGGAGCTG AGCAATCTGA CAAATGGCAT  5601 CCAGGAGCTG GGCCCCTACA CCCTGGACCG GAACAGTCTC TATGTCAATG  5651 GTGAGCAGCT GTGATGTGGT TGGAGGCTCT TCCTCCTTGC TGAGCAGCCT  5701 GTAATCACTG GCTTGAGGTC ACACTCACTG TCAGGCAATT GAAAATTTGG  5751 TCCTGTGCTC TACATGGGAT GACTAATTTC CGGACTTCAT GGTATCTTTT  5801 TTTTTTTTTT TTTTTTTTTG AGATGGAGTC TCGCTCTGTC ACCAGGCTGA  5851 GGTGCAGTGG CATGATCTCA GCTCACTGCA ACCTCCGCCT CCCGGATTCA  5901 AGCAATTCTC CTGCCTCAGC CTCCTGAGTA GCTGGGACTA CAGGTGCATG  5951 CCACCACACC CAGCTAATTT TTGTATTTTT AGTAGAGACA GGGTTTCACC  6001 ATGTTGGTCA GGATGGTCTC AATCTCTTGA CCTTCTACTC CACCTTGCCT  6051 TGGCCTCCCA AAGTACTGGG ATTACAGGCT TGAGCCACCA CACCTGGCCA  6101 GGACTTCATG GTTTCTTCAT CATCATGGAA TGAATTCCAT CAGGGCATTC  6151 TTCCCTGATG TGAGGGCACT GATAGGAAAT CTTTAATGGT CCCTGCTGCA  6201 TGAAACTGCT TCCATTGCAC CAGGGTAGCC CTGACCCCTA TTTGGTCCCC  6251 CACATCTCCT TGTAACTTAC CCACACTCCT CCCTCCTTCT CTGTGCAGGT Exon R4  6301 TTCACCCATC GAAGCTCTAT GCCCACCACC AGCAGTGAGT ATTCAACTCA  6351 TGTCCACATG CCCATGATCC TACACCAAGC AAAGCAGGAG CTGCCCCTCC  6401 TCATAAACCC ATAAGTCCTC CTCTTGAGCA AAGTAGCTGG GAAGGCAGAA  6451 GTTATTCAAG CTCCCCTCTG CCCCAGTTTC AAAGACAGAC TCAGCTCAAG  6501 CCCACATGCA GCAAACCCTA TAAAAGTCTC ACCTCTTGGC ATTTCTGCCA  6551 TGGTAATGCT TTCTGCTCTC ACTAATGAGG ACTTCTCCTC AGCTCCTGGG Exon R5  6601 ACCTCCACAG TGGATGTGGG AACCTCAGGG ACTCCATCCT CCAGCCCCAG  6651 CCCCACGAGT AAGTACCAGT CAATGGCATC TCTATTAGAG CATGCTATCT  6701 CTGTCATTTT TACTCAGATG AAGATGGAAA ATCATAGCAA ATCTACTGAT  6751 AGTGAGTGGA CCAACGAAAT TTGTTGGCCA CCTAGTGTGT ACCAGATCCT  6801 AGAGATACAG GAGGGAAAAC AAAACCAATA CAAAATTTCT GCTCTCAGTG  6851 AGCTTGTATT CTTGTCATGA TGATGATGTT GGTGGTGGTG CTGTTGATGA  6901 CGATGATGAT GATGATGATG ATGATGATGC TGGTGATACT GTTGATGGTG  6951 ATAGTGATGT TGATGACAAT GATGATGATG ATGATGTTGA AGAAAATGAT  7001 GCTGGTGATG GTGGTGGGGG TTATTATGGT AATAATGATA TGTTGAGTGT  7051 GACGATGATG GTGGTGGTGT TGATGATGAT GATGATTATT ATGCTAGTGA  7101 CATTGATGAT GGTAATGGTG ATATCAACGA CAGTGACAAT GATGGTGATG  7151 AGGATGATGT CGGTGATGGT GGTGGGGTTA TGATGGTAAT GATATGTTGA  7201 ATGTGATGAT GGTGATGATG ATATTTGTGG TTCATGATGG GGATTGTCAT  7251 GGTGGTGCTG GTGGTACTTG TGATGACAAT AATGATAATA ATGATGACAA  7301 TGATAGTGAT GATGGTGATG GTGATAATAA AGATAACAGA TATCACCTTA  7351 CAATATTGAG CACTAAATAT GTACCAAGAG CTATGCTCAG TATCTAACTA  7401 CTATTATATA ATCTACTTTA GAAAATGAAT TGTATCATAG ATAAGAAAGG  7451 CGTGGAAAAT ATTTATTATG TCACTCAATT TAATTGCTGC ATATGGTTAT  7501 TACAAAGTGC TATTCTCTCT ACTTTGAACA TAATGTTTAT TTCACACTCC Exon R1  7551 CACTATAGCT GCTGGCCCTC TCCTGATGCC GTTCACCCTC AACTTCACCA  7601 TCACCAACCT GCAGTACGAG GAGGACATGC GTCGCACTGG CTCCAGGAAG  7651 TTCAACACCA TGGAGAGTGT CCTGCAGGGT CTGGTTAGTG TCCTGCCCTC  7701 CACACTCTGC CCTGCTCATG ATACCCAGTC CCTCTTACAT CATCCATGCC  7751 AGGGCAATGG AAGAATATCA AACCCAACTC ACTTTTGCCC CAAGAGATGC  7801 AAGCCTCAGC CAGGAGCGGT GGCTCACGCC TGTAATACCA GCATTTGGGA  7851 GGCCAAGGCG GGTGGATCAC CTGAGGTCAG GAGTTTGTGA CCAGCCTGGC  7901 CAACATAGTG AAACCTCATC CCTACTAAAA TACAAAAATT AGCCAAGCAT  7951 GGTGGTGCAT GCCTGTAATC CCAGCTACTT GGGAGGGTGA GGCAAGAGAA  8001 TCACTTGAAT CAAGGAGGCA GAGGTTGCAG TGAGTCAAGA TCATGCCACT  8051 TTACTCCAGC CTAGGCAAAA AAGCGAAACT CCATCTCACA AAAAAAAGAA  8101 AAAAAGAGAG AGATGCAAGC CTCCCCCACC AAGGCCAGCC CTGCCCACCT  8151 CACTTCTGCC TGGCTCTTAC ATAAAACTTA GCCCTCCTAC TCACTGCCCT Exon R2  8201 CTCCCTCCTC CACAGCTCAA GCCCTTGTTC AAGAACACCA GTGTTGGCCC  8251 TCTGTACTCT GGCTGCAGAT TGACCTTGCT CAGGTGAGAA CTTAGAATTT  8301 CCAGCCTGGC TGCCCCACTT GTACTCACTC CAAAAGACTT TGCACTGCTT  8351 CCTTGCTGCA CTTCCTAGGG ATATCCTCAC CAAAGGTGGA ATTCAGGAGT  8401 CACAGGCTTC AGGATCAGTG TGTTTCCTGA CAGTAACACC CCTACACTCC  8451 ACCTCAACAG AGAGAATCTG CATGGCCCAT CATCAGGATT GAGCCTCTCC  8501 CTTTATCATC CCTCTGAATT CCCTCCATTC CCTGTGCCTC CCTTTCCTTT  8551 ACATGTTAAA TTCTGTCCCC AGGATTTCTT TCAGGACAAT CATGCCTTAT  8601 CCACGTGATT TCATCCTCAT TTCGAGCTCT TCACTGGGCT CAAGTCCGGC  8651 TCCCCGTCCC GTCCATGAAA GTGTCAGTTT CATCTTGTCA CTGTATCCGT  8701 GACTCCACTC ACAGTCCTCA GCAAGCCAAT AGTCCATGCA CTAAGAGTCG  8751 ATGTGGCTTC TCACCTCTTT CCCAGGTTTC TCATTTCTCT GGTCCTTGCT  8801 GTCCTTCCCT CAGCAATCGC AAGACCCTTC CTAGATAAAC TTTTCATTGT Exon R3  8851 GATTTTTCCC ACTGACCCTC CCCAGGCCCG AGAAAGATGG GGCAGCCACT  8901 GGAGTGGATG CCATCTGCAC CCACCGCCTT GACCCCAAAA GCCCTGGACT  8951 CAACAGGGAG CAGCTGTACT GGGAGCTAAG CAAACTGACC AATGACATTG  9001 AAGAGCTGGG CCCCTACACC CTGGACAGGA ACAGTCTCTA TGTCAATGGT  9051 GAGTGGCTGT GATGTGGTTG AAATCTCTTC CCCCTTGCTG GGCAGCCTCT  9101 AATCTCTAAC TAGAGATCAC ACTCCCTGCC TGGCCTTTGA AAATTCTGTC  9151 ATGTGCTCTA CATGGGATGA CTAAGGTCTG GACTTCATGG TTTCCTTACC  9201 ATCATGGACT GTGTTCCCTC AGGGCATTCT TTCCTGATGT GAGGATGCTG  9251 ATAGAAAATC TTCAATTGTC CCTGTACCAT GAAACTCGGT TCATTGCACC  9301 AGGGTAGCAT TGACCTCCAT TTGGTCCCCC ACCTCTCCTT GTCTCTTACC Exon R4  9351 CACTCTCCTC CCTCCTTCTC TATGCAGGTT TCACCCATCA GAGCTCTGTG  9401 TCCACCACCA GCAGTGAGTA TTCAACTCAT ATCCACATGC CTCGGTTCCT  9451 ACACCAAGAG GAGCAGGAGC TGGCCCCTCC TCATAAACCC ATTAAGTCCT  9501 CTTCATAAGC AAAGGATTTA GGAGGGCAGA AGTTATTTAA GTGTCCCTCT  9551 GCCCAGCTCA AGAGACCGAC CCAGCTCAAG CTACACATGC AACAAACCCC  9601 ATAAATAGTC TCCCCTCTTG CCATTTCTGC CAAGAGAGTG CTTTATGCTT Exon R5  9651 TCACTGATGA GAACTTTTCC TCAGCTCCTG GGACCTCCAC AGTGGATCTC  9701 AGAACCTCAG GGACTCCATC CTCCCTCTCC AGCCCCACAA GTAAGTATCA  9751 GTCAATGACA TCTCTATGAG AGCATACCTG ATTAGTGTAA ACATCTCTGT  9801 CATTTTCACT CAAATAAAGA TGGAAAATCA TAGTAAATCT AGTGATACTG  9851 AGTGGACAAA TTTGTTTGTT TGTTTTTTCT CATCCTTTTC ACTTTTTTTA  9901 TTATACTTTA AGTTTTAGGG TACATGTGCA CAATGTGCAG TTTAGTTACA  9951 CATGTATACA TGTGCCATGC TGGTGTGCTG CACCCATTTG CTCGTCATTT 10001 AGCATTAAGT ATATGTCCTA TGCGATCCAA GCCCACGCGC CGCACCACGT 10051 GCAACAGTTT CACAGATTGG ATGGTCCGAT ANNNNNNNNN NNNNNNNNNN 10101 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 10151 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN Exon R1 10201 CTTCACCATC ACCAACCTGC AGTATGAGGA GGACATGCAT CGCCCTGGAT 10251 CTAGGAAGTT CAACACCACA GAGAGGGTCC TGCAGGGTCT GGTTAGCACC 10301 CTGCCCTCTT CACTCTCCCC CGCCCTGGAT GCCGAGCCCC TCATACAACA 10351 TTCATGCCAG GGCAATGGAA GAATATCGCA CCAACCTTGC CCTCATCCCC 10401 AGAGATGCAA GCCTCACCCA CTGAGGCCAG CCACTCTCAT GGGTGTCTGC 10451 CCCACCCACC TCACTTTTGT CCCCACACAG GGACCTTAGC CCTCCTACTT Exon R2 10501 ACCTCTCTCT CCCTCCCCCA CAGCTTAGTC CCATATTCAA GAACACCAGT 10551 GTTGGCCCTC TGTACTCTGG CTGCAGACTG ACCTCTCTCA GGTGAGACCT 10601 TAGAAGATCC AGCCTGGCTG CCCCAGTTGT TCCCACTCCA GTAGATTTTG 10651 CTCTGCTTCC TTGCTGCACC TCCTAGGGAT ATCCTCACCA AAAGGGGAAT 10701 TCAGGAGTCA CTGGCTTCTG GACCAATGTG TTTCCTGATA GTAACACTCC 10751 CACACCTCAC CTCAACAGGG AGAATCTGCA TGGTCCATCA TCAGGATTGA 10801 GCCTCTATCC TGATCATCCC TCAGAATTCC CTGCCCCTCC CTTTCATTTA 10851 GGTGTTAAAT TCTGTCCCCA GAATTTCTCT CAAGACAATC ATGCCTCATC 10901 CAAGTGCTTT CATCCCTGTT TCTAGCTCTT CACTGGTCTC AAGTCTGGGC 10951 TCTCCTGTCC CCATGCTATG AGAATGCAGG TTTCACCTTG CACTTTTATA 11001 AGCATGGTTG TATCTGTGAC TCTGTGCACA GTCCCAAGCA AGCCAGTAGT 11051 CCATGCACTC AGAGAATCTA AGTGTAGCTT CTCACCTCTT TCCCAGGTTT 11101 CTCATTTCCT CTGGTTCTTT ACTGTCTTTC CATCAGCAGT CTCAGGACAC Exon R3 11151 AACCTAAGTA ATCTTTTCAT AGTCATTCTC CCCACCTACC TTCCCCAGGT 11201 CTGAGAAGGA TGGAGCAGCC ACTGGAGTGG ATGCCATCTG CATCCATCAT 11251 CTTGACCCCA AAAGCCCTGG ACTCAACAGA GAGCGGCTGT ACTGGGAGCT 11301 GAGCCGACTG ACCAATGGCA TCAAAGAGCT GGGCCCCTAC ACCCTGGACA 11351 GGAACAGTCT CTATGTCAAT GGTGAGCAGC TGTGATGTGG TTGGAGTCTT 11401 TTCCTTCTAG AGTCTGGAAA GAATCTAATC TGTGGCTTGA AGTCACACTC 11451 CCTGCCTGGC CATTGAATAT TCTGTCATGT GGTGTAGATG GGATGACAAA 11501 GTTCTGGACT TCACAGTTTC TTCATTGTCG TGAACTGTGT TCCCTCAGGG 11551 CACTCTTCCC TGTTGTGAGG ATACTGATAG GAATTCTTTA ATGGCCCCAG 11601 TCCCATGAAA CTCATTGTCC CATGAAACTC ATTTAATTGC ATTGGGATTG 11651 CCATGACCTT ATTGTGTCCC TCGTATCTCC TTAACGCTTA CCAAGTCTCC Exon R4 11701 TCCCTCCTTC TCTATGCAGG TTTCACCCAT CGGACCTCTG TGCCCACCAC 11751 CAGCAGTGAG TATTCAACTC ATGTCCACAT GCCCCTGATC CTACATTAAG 11801 TGGAGCAGGA GCTGGCCCCT CCTCTTAAAC CCATAAGTCC TCCTCTTGAG 11851 CAAAGGAGCT GGGAAGGCAG AAGTTATTGA AGCTCCCTTC CACCTAGCTC 11901 CAAAGACAGG CCCAGCTCAT GCCCGTATGC AGCAGACCTC ATAATAGTCT 11951 ACCTTCTTGC CATTTCTGCC ATGAGATTAT TTTCTGCTTT CACTGATGAG Exon R5 12001 CACTTTTTCT CAGCTCCTGG GACCTCCACA GTGGACNNNN NNNNNNNNNN 12051 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 12101 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN Exon R1 12151 ATTTTCAATT CCCACTACAG CTGCTGGCCC TCTCCTGGTG CTGTTCACCC 12201 TCAACTTCAC CATCACCAAC CTGAAGTATG AGGAGGACAT GCATCGCCCT 12251 GGCTCCAGGA AGTTCAACAC CACTGAGAGG GTCCTGCAGA CTCTGGTTAG 12301 TGCCCTTCCC TCCTCACTCT GCCCAGCCCC AGATATCCAG TCCCTTCTAC 12351 ATCATCCATG CCAGGGTGAT GAAAGAAGAT AGCAACAACT TCCCCCCTTC 12401 CCCCCAAGAG ATGCAAGCCC CACCCACAGA GACCAGTCCT GCTTATTGGT 12451 GCCTGCTCCA CCCACCTCAC ATCTGCCCCG ACACACACAC ACCTTAGCCC Exon R2 12501 CACTACTCAC CTCCCTCTCC CTCCTCTACA GCTTGGTCCT ATGTTCAAGA 12551 ACACCAGTGT TGGCCTTCTG TACTCTGGCT GCAGACTGAC CTTGCTCAGG 12601 TGAGACTTTA GAAGAGCCAG CCTGGGTGCC CAAACTTGTT CCCACTCTAA 12651 AAGACTTTGC ACTGCTTCCT TGCTGCACTT CCTAGGTATA TCTTCACCAC 12701 AAGGGGAATT CAGGAGTCAT TGGCTTGAGA ACCAGTTGTT TCCTGATAGT 12751 AACACCCCCA TGCCCCAACT CAACATGCAA AATCTTCATG GTTCATCATC 12801 AGGATTGAGA CACTACCCTG ATTACCCATC TGAATTCCCT CCTTTCCCTG 12851 ACCCCTCCCT TTCATTTAGG TGTTAAATTC TGTCCCCAGG ATTTCTCTCA 12901 AGATAACCAT GCCTCATCCA CATACATGCA TCCGCCTTTC AAGCTCATCA 12951 CTAGTCTGAA GCTCTGGGTT CTCCTGTTCC CATGCCATGA GAATGCAGGT 13001 TTCACCTTGC ACTTTTATAA AAATTATTAT ATCCATGACT CTGCTTGCAG 13051 TCCCAGACCA AGATAGTGGT CTATGTACTC AGATAATCTA AGTGCAGATT 13101 CTCACCTCTT TCCCAGATTT CTCATTTCCT CTGGTTCCTT GATATGTTTC 13151 CCTCAGCAAT CTCAAGACAA GTCCTAGGCA ATCTTTTCAT TGTCATTCCC Exon R3 13201 CCTCCTACCT TCCTCAGGTC CGAGAAGGAT GGAGCAGCCA CTGGAGTGGA 13251 TGCCATCTGC ACCCACCGTC TTGACCCCAA AAGCCCTGGA GTGGACAGGG 13301 AGCAGCTATA CTGGGAGCTG AGCCAGCTGA CCAATGGCAT CAAAGAGCTG 13351 GGCCCCTACA CCCTGGACAG GAACAGTCTC TATGTCAATG GTGAGCAGCT 13401 GTGATATGGT AGGGGTCTCT TCCTCCTGGC TGTGCAACCA TCTAATCTCT 13451 GGCTTGGGGG CACACTCCCT GCCTGGCCAT TGAAAATTCT GTCACGTGCT 13501 CTACATGGGA TGACTAAGTT CTGGACTTCA TGGTTTCTTT GTTATCATGA 13551 GAGGCATTCC CTCTGGGCAC TCTTCCCTGT TGTGAGGATG CTGATAGGAA 13601 ATCTTTAATG ACCCCTGTCC CATGAAACTC ATTTAATTGC ACCAGGGTAG 13651 TCCTGAACTC TATCGCGTCC CCCACATCTC CTTAACCCTT ACCCAGTCTC Exon R4 13701 CTCCCTCCTT CTCTATGCAG GTTTCACCCA TTGGATCCCT GTGCCCACCA 13751 GCAGCAGTGA GTATTCAACT CATGTCCATG ATGCCCCTGA TCCTACATCA 13801 AGTGGAGCAA GAGCTGGCCC CTCCTCTTTA ACCCATAAGT CCTCCTCTTG 13851 AGCAAATGAG CTGGGAAGGC AGAAGTTACT CAAGCTCCCC TCTGCCCCAG 13901 CTCCAAAGAC AGACCCAGCT CAAGCCCACA TGCAGCAGAC CTCATAATAG 13951 TCTATCTTCT TGCCATTTCT GCCATGAGAG TGCTTTCTGC TTTCACTGAT Exon R5 14001 GAGGACTTTT TTCAGCTCCT GGGACCTCCA CAGTGGACCT TGGGTCAGGG 14051 ACTCCATCCT CCCTCCCCAG CCCCACAAGT AAGTACCAGC CAATGGTATC 14101 TGTATTAGAT CATGCCTGAT GAATGCAAAC ATCTGTGCCA TTTTCAGTCA 14151 AATGAAAATG GAAAATCATA ATAAATCTAG TGATACTGAG TGAACCAAAA 14201 AAAATGTATT GGCCACCTAC AGTGTACCAG ACCCTAGGGA TATAGCAAGG 14251 AAAATAGAAC CAATAAAAAC ATCTCTGCCC TCAGTGAGCT TGTGTTCATG 14301 TGATGATATG ATGGTGGTGG TGGTGGTAAT AGTAATAATG ACATATTCAG 14351 TTTGATGATA ATTTATGATT ATGGTGTTGC TGTTGATGAT GGTGGTGGTG 14401 ATGTTACTGA CAATGATGGT GACGGATCTT TGAGGATATT GTCCGTGATG 14451 GTCGTGAAGA TTATGATGAT AATGATGATG TGTTAAGTGT GATGATGATG 14501 ATGATCTGTG GTGATGCTGT TTAGGATGCT GTTCCGTGGT ACCGATGATA 14551 TTGATGTTGG TCGTGGTTAT GTTGTATGAC AATGACAATG ATGGTGATGA 14601 GGATAATCGC CAGTGATGGT GTGGGTTTAT GATGATGATG ATGTGTTGAA 14651 TGTGGTGATG ATAATGTTCG TGGTGGTCGT GATGGGCATT ACTATGGCAG 14701 TGATGGTCAT AATAATGATG GTGATGGTGA CAATGATAGC AAGGATGATG 14751 ATGGCAATAA AGATAGTACA TAACATCAGA CAATATTGAG CTCTGAATAT 14801 GCACCACGAG GAGTGCTCAG CATCTAAATA CTATTATATA ATATATTTTT 14851 GTAAAAATAA ATTGTATTGT TTTAGGCAAG GGAAGCATGG TAAATATTTT 14901 GTCACTCAAT TTAAATTCTG CATATGTTTA AAGATAAGTC TATTGCAAAC 14951 TCCTATTTTC TCTACTTTGG ACATAGTGTT TGTTTCCCAC CTCCACTACA Exon R1 15001 GCTGCTGGCC CTCTCCTGGT GCCATTCACC CTCAACTTCA CCATCACCAA 15051 CCTGCAGTAC GAGGAGGACA TGCATCACCC AGGCTCCAGG AAGTTCAACA 15101 CCACGGAGCG GGTCCTGCAG GGTCTGGTTA GTGCTCCACC CTCCTCACTC 15151 CGCCCCACCC CAGAGAGTCA GTACCTCCTA CATCATCCAT GCCAGGTGAT 15201 GGAACAAGAT CATACCCACC TCACCCTTGC CCCAAGAGAT GCAAGCCATG 15251 CCCATTGAAA CCAGCCCCAC TCACTGATGC CTGTTACTGC CCCACCTGAC 15301 TTCTGCCCTA CACACCCACA CACGCAACTT AGCCCTCCTA CTCATCTCCT Exon R2 15351 TCTCCCTCCT CCACAGCTTG GTCCCATGTT CAAGAACACC AGTGTCGGCC 15401 TTCTGTACTC TGGCTGCAGA CTGACCTTGC TCAGGTGAGA CCTTAGAAGA 15451 TCAAGCTTGG CTGCCCCACT TGTTNNNNNN NNNNNNNNNN NNNNNNNNNN 15501 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 15551 NNNNNNNNNN NNNNNMNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN Exon R1 15601 NGTGTTAGTC TACTTTTGAA CACTGTTTAT TTCCCATCTT CACTATAGCC 15651 GCCAGCCCTC TCCTGGTGCT ATTCACAATT AACTTCACCA TCACTAACCT 15701 GCGGTATGAG GAGAACATGC ATCAGCCTGG CTCTAGAAAG TTTAACACCA 15751 CGGAGAGAGT CCTTCAGGGT CTGGTAAGAG CCCCACATAC CTCATTCTAC 15801 CGCCACTCAC CATGTTTAGT CCTGCCCACC TCACCTATTG CAGAGCATGG 15851 AAGATCTCAT CTACCTCATC TTGCCCCCAG ATATGCATAC CCCAACCACT 15901 GATGCCAGCC CCACCAACTG TTGCCAGCCC TGCCCACCTC CCTTCTACCA 15951 CACCCCTATG ACTTCAGTCC TCCCACTCAC CTCCCTCTCC CTCCTCCACA Exon R2 16001 GCTCAGGCCT GTGTTCAAGA ACACCAGTGT TGGCCCTCTG TACTCTGGCT 16051 GCAGACTGAC CTTGCTCAGG TGAGAACTGA GAACAGCCAG TCTGACTGAT 16101 CTGAGCAGTT TGACCTGCTT CCCTTCTGCA CTCCCTGGAG ATGTCCGCAG 16151 CCAGGTGGAA TCCAGGAGGC AGTGGCTCTA AGACCAATGT GCTTCCTGTT 16201 CCCACCACCT CCCACCTCAA CTGAGAGATG CAGAGCCCAT CAGCAGGACT 16251 GAGCTTCTAC CTTGGTCATC CCTCTGAATT CCCTCCTTTC CCCTACCTGC 16301 CTTTCCACAA GTGGTTCAAT TCTGTTCCCA GGATTTCTCC CAAGAAAAAC 16351 ATGCCTCGTC CACTTGCTTT CATCCCCAAA CCTAGCTCTT CACCTGTCTC 16401 AAGTATGAGT TCTCCTTACC CCATGCTACA AGAATGCAGT TTCCACTTTG 16451 CAATTTTATA AAAATCCTTG CATCCATGAT TCTGCTCATA GTTGCTAAGA 16501 GTCAGTGCAC TCAGAGAATG GAAGTATGGC TTCTCACTTC TCTACCAGGC 16551 TTCTCATTTC CTCTGGCCCC CTCCTGTCCT GCCCTGTGGG ATCTCAGAAC 16601 CCCTCCCTAG GCAATCCGTG TATTGTCTTT CCCCAATCTT GCCCTCCCCA Exon R3 16651 GGCCCAAGAA GGATGGGGCA GCCACCAAAG TGGATGCCAT CTGCACTTAC 16701 CGCCCTGATC CCAAAAGCCC TGGACTGGAC AGAGAGCAGC TATACTGGGA 16751 GCTGAGCCAG CTGACCCACA GCATCACTGA GCTGGGCCCC TACACACTGG 16801 ACAGGGACAG TCTCTATGTC AATGGTGAGT AGTTGTGATG TGGTTGGAGT 16851 CTCTTCCTCC TTGCTGGGCA GCCTCTACTC TCTGCCTTGA GGTCACGCTC 16901 CCTGCCTGGC TATTGAATGC TCATCCATGT TGTCTGTATG TGATGGCTGA 16951 GGTTGGAACT TCATGGTTTC TATTTCATCT TGGACTGAGT TCATCCTCAG 17001 GATCTGCTTT CTGGATCTGA GGGTGCTGAT AGAGAATCTT CAATGGTTCG 17051 TGTTCTGGGA AATTCCTTCC ATTGCACCAG GGTACCCTGA CCCCTATATA 17101 GTTCCCCACC ACTCCCTTAA CCCTTACCCA CCCTCTTCCC TCCCTCTCTA Exon R4 17151 TGCAGGTTTC ACACAGCGGA GCTCTGTGCC CACCACTAGC AGTGAGTATC 17201 CACTGATTTC CAGTGCTCCT GATCCTACAT CATGCAGGGC AAGAACTGAC 17251 CCCTCCTCAC ATGCCCCTAT GTCCTCTATG AGCAAAGGAG CTGGGACAGC 17301 ACAAGTTACT CCCTTTCCCT TCTGGCCCAA GTCTCTTCAG AGAGAGACCC 17351 AGCTCAAGCC CCACATGCAG CAAGGTCCAT AAATACTCCT ACCTGCTGGC 17401 ATTTCTGCCA TGAGAGGGTT CAACACTTTC ACTAATGAGG CCTTCTCCTC Exon R5 17451 AGTTCCTGGG ACCCCCACAG TGGACCTGGG AACATCTGGG ACTCCAGTTT 17501 CTAAACCTGG TCCCTCGGGT AAGTACAAAT CAATCGCATC TCTGTTAGAG 17551 CATGCCTGAT GACTGTCAAC ATCTCTGCCA TTTTCACTTA AATAAAGATA 17601 AAAAATCCTA GTGAATCTAC GGATGAGGAG TCATCCAGCA AACTTAATTG 17651 AGTGCCTAGT TTCTGCAGGG CTCTAGGGAT AAGAAAGGGG ACACAAAACA 17701 GTTAAAAATA TCTGCTGCAA GAAAGCTTAT TTTATTGTGA GGGTGATGGG 17751 AGTTGGTGGT GGTGAAGTTA CTGGAGATGA TGACAATAAG AATGGTGATG 17801 CTAGTGATGA TGATGGTGAT AAGGATGATA ATTATGAAGA TGGTGGTGGT 17851 GATGATGATG ATGGTNNNNN NNNNNNNNNN NNNNNNNNHN NNNNNNNNNN 17901 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 17951 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 18001 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN nNNNNNNNNN NNNNNNNNNN 18051 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 18101 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 18151 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 18201 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 18251 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 18301 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 18351 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 18401 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 18451 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN Exon R1 18501 MNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NGCTGCCAGC CCTCTCCTGG 18551 TGCTATTCAC TCTCAACTTC ACCATCACCA ACCTGCGGTA TGAGGAGAAC 18601 ATGCAGCACC CTGGCTCCAG GAAGTTCAAC ACCACGGAGA GGGTCCTTCA 18651 GGGCCTGNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 18701 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 18751 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 18801 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN Exon R2 18851 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNCTC AGGTCCCTGT 18901 TCAAGAGCAC CAGTGTTGGC CCTCTGTACT CTGGCTGCAG ACTGACTTTG 18951 CTCAGGNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNAGAAT 19001 TCAGTCGACC TACCGGCTTT GATGATTGCT CAGTTGAACT TAGAAATGCA 19051 CTGTCTGCCC AATGGTCCAG TCTCATGAGT GTGACTCTTT TCTGCCTCTC 19101 TTGGGTATCT GATCAAGATG GACTCAGGAA AAGTGCTCCA GATATCTGTC 19151 TCCAATATAA CACTGCCCCT GCCATCACAC CCAAATGACT GGAAGTTTCA 19201 CAGGGTCATC AGCAGGGATT GGACTTCCAC CCCGGCCATC CCTCTGAATT 19251 TTCCCTCTTT TCTCCCCACC TCCCTTGCCC TTAGGTGTTA AAATTCTCTA 19301 ACTAAGATTT CTCTCAAGAC AAATGTGCCT CATTCACTTG TTTAATTCCC 19351 AATTCCAGCT TGTCACCTGT CTCAAGTCTA GGCTGTCCTG TCCCCATGCC 19401 ATGAGAATGC AAGAACCACA CTGAAATGTT AGAAAAATTC TTTTATCCAC 19451 AAGTATGCTC ACCGTCCCAA GCTGGACAGT AGTCAGTGCA CTCAGAGAAT 19501 CTAAGTGTGG CTTCTCATCT GTGTACCAGG CTTCTCATTT CCTGTGGGCC 19551 CTTCTTGTCC TTCCCTCCGC AATCTTGGGA CTCCTCCCTA GACAAAACTT Exon R3 19601 TATTATTATT CCCCTCACCT GCCCTCTCCA GGCCTGAAAA GGATGGGACA 19651 GCCACTGGAG TGGATGCCAT CTGCACCCAC CACCCTGACC CCAAAAGCCC 19701 TAGGCTGGAC AGAGAGCAGC TGTATTGGGA GCTGAGCCAG CTGACCCACA 19751 ATATCACTGA GCTGGGCCCC TATGCCCTGG ACAACGACAG CCTCTTTGTC 19801 AATGGTGAGC AATTGTGATG TGGTTGGAGT TTCTTCTTCC TTGCTGAGCA 19851 GGCCTCTACT CTCTGTCTTG AGGTCACTCT CCCTGCCTGG CCACTGGTCT 19901 TGGCCATGTT GTCTGTATTT GATGATTGAT ATGAACTTCA CCGTTTCTTC 19951 TTCATCTTGT ACTGGAGACC TTCATCCTCA GGACCTTCTT CCCTGATCTG 20001 AGTGTACTTG TATAGAATCC TCAAAGCCCA TGTTCCCTGA AACTCCTTCA 20051 ATTGCACCAT GGTAGCACTG ACCCCTTTTG GTCCCCCACC TTNNNNNNNN Exon R4 20101 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN TTCACTCATC 20151 GGAGCTCTGT GTCCACCACC AGCACTNNNN NNNNNNNNNN NNNNNNNNNN 20201 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 20251 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 20301 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN Exon R5 20351 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNCCTG GGACCCCCAC 20401 AGTGTATCTG GGAGCATCTA AGACTCCAGC CTCGATATTT GGCCCTTCAN 20451 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNGACTCCA GCCTCGATAT 20501 TTGGCCCTTC AGGTAAGTAC CAGTCAATGG CACCTCTATT AGAGTATGCA 20551 TGATGAGTGT CAACATCTCT GTCCTTTTCA CTCAAATAAG ATTAAAAATC 20601 ATAGCAAATT GTACGTGATG ATGAGTCACC CAACAAACTT CTTTGAGTAC 20651 CCACTCTCTG CCAGGCCCTA GAGATAAGGC AGGGAACACA AAAGAGGTAA 20701 AAATCTCTGC CCTCAGAGAG CTTCTTTTAT TTTGAGGATG ATGTGGGATA 20751 GTGGTGATGA TGATGTTGCT GGAGATGATT ACAATAATGA TGGTGATGCT 20801 TATGACCATG ATGTGATGAT GATGGTGATT ATGAAGATGA TGATGATGAT 20851 ATTGATGATG GTAGTGGTTT TGACAGTAAT GATGATGTGA TGATGATGAT 20901 GATAGTGGTG GTGGTGATTA TGGGAAGGAT GACAGTGGTG GTGGTGATGG 20951 TGGTGGTTGT GGTGGTGATT GACAATGTGG TGGTGATATT GACAATGAGG 21001 ATGATGATGA TAGTGGTGGT GGTTATGATG GTTAAGGATG ATGTGATGAT 21051 GGTGTTGGTG ATCACGGTAC TAGTGGTGGT GATGTGGACC GTCATGGTTG 21101 TGGTTGTGGT GGTGATGGTG GTGATCATGA TGATAATGAG GATGATGGTG 21151 GTGATTGTCA TGATGGTAAG GATGAAACAG TGATGGTGTT GGTGACCATG 21201 TTCCTGGTGG TGATGGTGCA GGTGATGATG TGGATGATGA TGGTGATGGT 21251 GGTGGAGATG ATAGGGATTA TGAATATGGT TCGGGTCTCT GACTGGTGGT 21301 GGTGATGACA ATAATGAAAA TGATGGTCAC AGTGTTGGTG ATGATGATGG 21351 TGGTGATAAC AAAGGTAATA GATAGTGTCT AGTATTATGG AACACAGAAC 21401 ATCACCAAAG GTTATGCTCA GCATCTAACT ATTATTATTT AGCATGCTCT 21451 ATGAAAAACT TTGATCGTTA TAGTCAAGGG AGGCATGAAA ACCTTCTATT 21501 TTATCACTCT CTTTAAATCT GGTTGCATAT GTTTAGAAAT AAATCTATTA 21551 CAAACTCTTA AATGTTCTCT ACTTTTGAAC ATAGTGTTTA TTTCCCACCT Exon R1 21601 CCACTACAGC TGCCAGCCAT CTCCTGATAC TATTCACCCT CAACTTCACC 21651 ATCACTAACC TGCGGTATGA GGAGAACATG TGGCCTGGCT CCAGGAAGTT 21701 CAACACTACA GAGAGGGTCC TTCAGGGCCT GGTGAGAGCC CTGCCCACCT 21751 CACTCTGCCC TGCCCACCTT GTCTTGTTCC ACCTACGTCA CCCATTCCAA 21801 GGCATGGAAG AAGATCTCAC CCACCTCCCC TCACCTGAGA GATAGCCCCG 21851 CCCCCTGATT ACAGCCCCTT CCACCTTACA TCTTCCTCAC TTCTATGTCC Exon R2 21901 TCAGCCATCT TACTCACCTC CCTCTTCCTC CTCCACAGGC TAAGGCCCTT 21951 GTTCAAGAAC ACCAGTGTTG GCCCTCTGTA CTCTGGCTGC AGGCTGACCT 22001 TGCTCAGGTG AGAACTGAGA ATAACCAGTC TGGCTACCCC AAGTGTTCCC 22051 AGGCCCAAGG AGTTTCATCA GCTTTCTTCC TTCCCTCCCT ATGGAAGTCC 22101 TCAGCACAAG TGGAATTCAG GCGTTGGTGG CTCCAGGATG AACATATCTG 22151 CTGATCCTAC CACCTCCCCC ATCAATCGAG AGAATTTGCA GGGCCCATCA 22201 GCCAGATCAG GCTTCTACTT TGGTCATCCT TCTGAATTTC TTACTTCTCC 22251 CTACCTCCCT CTCCTTCAGG TGTTAAATTC TCTTCCAAGG TTTCTCTCAA 22301 GATAAACATC CCCCATCCAC TTGCTTTCAT CCCCAATTCC AGCTCTTAAT 22351 ATTTCTCAAG TCTGGGCTCT CCTGTCCCCA TACCATGAGA ATGCAATTTT 22401 ATAAAATTCT TGTATTCCTG ACTCTACTCA CATTCCCAGG CTGCCTGGAA 22451 GTTGGTGCAT TCAGAGAATC TTAGTATGGC TTCTCACCTG TCTACCAGGA 22501 TTCTCATTTC CTCTGTCCCC TTCCTGTCCT GCCCCCAGGA ATCTCAGGAT 22551 GCCTCCCCAT AGGCAATCTA TTTAATGTCA TCCCCCTTAT CTGCCCTCCC Exon R3 22601 TAGGCCAGAG AAAGATGGGG AAGCCACCGG AGTGGATGCC ATCTGCACCC 22651 ACCGCCCTGA CCCCACAGGC CCTGGGCTGG ACAGAGAGCA GCTGTATTTG 22701 GAGCTGAGCC AGCTGACCCA CAGCATCACT GAGCTGGGCC CCTACACACT 22751 GGACAGGGAC AGTCTCTATG TCAATGGTGA GCGGCTGTGA TGTGGTTGGA 22801 GATTCTTCCT CTTTGCTGGA CAGCTTCTTA CTCTCTGACT TGAGGTCACA 22851 CTCCCTGACT GGCCATTGAC GTCTTGGCTA TGTTGTCTGT ATGTGATGAC 22901 TGATGTCTGA ACTTCATAGT TTCTTCATCT TGGACTGAGT TCATCCTCAG 22951 TACCTTCTTC CCTGATCTGA GGGTACTGAT AGAGAATCTT CAAAGGCCCC 23001 TGTTCCTTGA AACTTCTTCC ATTCCACTAG GGTATCTGTG ACCCCTATTT 23051 GATTCCCCAC CTCTCCCTTA ACCCTTACCC ACTCTCCTCC CTCCTTCTCT Exon R4 23101 GTGCAGGTTT CACCCATCGG AGCTCTGTAC CCACCACCAG CAGTGAGTAT 23151 TCAACCGATG CTCCAGTAGC CCCAATTATA CACCAAGCAG GGCAGGAGCT 23201 GTCCTGTCTT CCTATGCCCC TATGTCCTCT TCATAAAGGA AGGGGCTGGG 23251 AGGGCACAAG TTATTCCCTT TCCCTTCTGG CCAGCTCCAG AGAGAGACCC 23301 AGCTCAGGCC CGATATGCAG CAAGGCCTGT AAATAGTTTT ATTTGCTGAC 23351 CTTTCTGCCA TGAGAGGCTT GGATGCTTCC CCTGAAGAGG GTTTCTCTGT 23401 AGCTCTTGGG ACTACCACAG TGGACCTGGG AAACTCTGGG GATCCACCCC 23451 TTCTACTGGT CCCTTGAATA AGTACCAGCC AATGGCACCT CTGTTAGAGC 23501 ATGGCTGATG AGTGTAAACA TCTCTTCCAT TATTCAGTCA AATAAAGATG 23551 GAAATTCTTT ATAAATCTAG TGATGATGAG CCAACCAACA AACTTTATTG 23601 AGCATTGTGA CAAGCCCTGG GGCTCTGCCA AATCCTGGGG ATATGGCATG 23651 GATCATGAAA CAATTAATAA TCTCTCCTCT CAGAGAGCTA TTTTTATGAT 23701 GATACTGATG GTGGCAATGA TGATGATGTT GATGGTGATT ATGACCATGA 23751 TGACAATGGT GATGGTGGTG GTGATGATGG TAATGATGAT GATGGTGATG 23801 TTGGTAATGA TGGTGGTGAT TATGACAATA ATGATGGTGA TGGTGACAGG 23851 GATGGTGATG ATTATGATGG TGGTGGTGAT AACAAAGTTA ATGGATAATA 23901 TATGAACTTA TTGGCTACTG AATATGCACC AAAGTGCTAT GCTCAGTGTT 23951 TAACTAGTAC TATTTAATAT GATTTCTAAA AAAAATCTTG AATTATTATA 24001 GGCAGAAGAA TCATGGGAAC CTTTTATTTT GTCACTCACT TTAAGTCCTA 24051 TTGCATATTT TTTAAGTCAA TTGCAAACAC AGTTTCTCTG CTTTGAACAT 24101 TGTGTTTATA TCCAGTCACC CCAATAGTGC ATAAACCTGC TGATTGGAGC 24151 AACTGTGTCT TACTCCCTTG TGCTTCCCTA GTATCTGCTT CAGGACCTTG 24201 TACATGGTAG ATCGACAGAT TTAGATCTAC AGGAAAATAT GGATTTTCCC 24251 AGGGAAGGAA GGAATGAAGT ATGCTTTCTT ATAATGTATG GAAACTTTCC 24301 TCTTCTGCCT TGGTTCAACT TTAGTGTCTG CCAGAGTTTA CACTGGAAAA 24351 CTATATGGCA TCTGCTCCAC TCCCTCATCC ATGACAGACA TCATTAATTG 24401 ATTGCAGCAT TCATGGCAGA CATCACCAAT TGATAATAGC ATTCATTTTC 24451 TCTCAGTTCA AAACAGCTTC AGAATGGTTA CCAAAAAAAA AAAATTCAGT 24501 CGCTACCAAT TCAATTGGAG CTGACTCAGG ATTATGGGAC AGAATTCAAG 24551 AGAGTTAGGT TCCTTGATGA TGTGTAGTGG CTATTTGTTT TCCGGTCCAG 24601 GCTAATNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 24651 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 24701 CTTTGTGCGG CAAAGTTCAG GGGCCCCAAA AATTTCTGTG CCCCAATCAT 24751 GGCGGACCTA GGTTTAGGCA CAAATTCCAG GGATTAAGTC CCTGGAGATG 24801 TTATGGCTTT TGGTTTTCCT AGAAAGGCTC AGCTCAGGCT CAGCTTGGTC 24851 ATGCTGATAT CCTTTCTTCC ACTTGGTCGA TTTGGCTGTT GATACTTATG 24901 TATGCTTCAC GAAGTTTTTG TGCTGTGTTT TTCAGCTCCA TCGGTTGGTT 24951 TATGTTCCTC TCTAAACTGG TTATTCTAGT TAGCAATTCC TTTAACCTTT 25001 CATCAAGGTG CTTAGCTTTG CATTGCATTA GAACATGCTC CTTTAGCTCA 25051 TCGTACTTTT TTATTGCCCA TCTTCTGAAG CCTACTTCTG TCAATTCATC 25101 CATCTGATCC TCCATCCAGT TCTGCACCCT TAATGGAGAG ATGTTGCGGT 25151 CATTTGGAGG APAAGAGGCA CTCTGGCCTT TTGGGTTTTC AGCATTTTTT 25201 TGTTGATTAT TTCCCATCTT CAGGAGTTTT AGTTTCAGGC TTTGAGGCTG 25251 CTGATCCTTG GATGGGGTTT TTATGGGGGT CTTTTGGTTG TTGTTGTTGA 25301 TGATGATGAT GTTATTGTCA CTTTCTGCTT GTTTTTCTTT CAATAGTCAG 25351 GTCCCTCTTC TGTAGGGCTG CTGCAGTTTG CTAGGGGTTC ACTTCAGGCC 25401 CTATTCATCT GATTCGCTCC CATGTCTGGA GGTGTCACTC AAGGAGGCTT 25451 GGAGAGCAGC GAACATAGGT GCCTGCTTCT TCTGGGACCT CTGACCTCGA 25501 GGGACACCAA CCTGATGCCA GTAGGATCGC TCCTGTGTAG GGTGTCTGAC 25551 AACTATTGTT GGAGGGTTTC GCCCAGTTGA CTGGCATGGA GAGCAGGACC 25601 CATTTAATGA AGCACTTTGT CCCCTGGTGG AGAGGGGGTT CTTCACTGGG 25651 GGGAAACCAC ATGTCTGGGC TGCTTGGATT CCTCAGAACT ACCAGAGGAG 25701 AGGCTAAGTC TGCTGGTCCA CAGAGACTAC AGCCATCCCT CCCACTAGGG 25751 GCCCAAGCCC AGGGAGTCCA AATTCTGTCT CTGAGCCTCT GGCTGGAGTC 25801 TTTGGAGATC CTGCAAGGAA GCTCTGCCCA CTGAGGAAGG ATGGGTCAGG 25851 GTTAGCCCTG AAGAGGCACT CTGGCTGCAG ACTGCCACAG CCGGTGTGTT 25901 GGGCTGTGGG GACAAGTCTT GGGACCAAGC CGTCCAGCCT ACCCGGCTCT 25951 AGCAGGGGAA AAGTACAGCC TGGAGCTATT GAAAGGGGTG CCGCCCTTCC 26001 CCCGCCCAGG GAGCTTAGCG TGTTAGGCAG TTGTGAGTCC AGTGCTGGCT 26051 GTCGCCCCTT CCCCAAGGAA CAAAAAAGAC TTAGCAGGCA GCCGCAGCCA 26101 GTGCTGGTCG CCCCTCCCCC GGGGAGTTCC GTAGGCTTAG GCAGATTCCA 26151 GCTGTAAGAA TCTGCGTGTT CTGGGGTTGG GACACTAGGT CCCAGTGGCA 26201 TGGGTTCGCG AGTGAGATCT TCCAATCTGT GAGTTGCACA GTTCCGTGGA 26251 AAAAGCACAG TTTCCCCCTC TTGGGTAGCC CGCTCACTCA CCACCTCCCT 26301 TGGCTGGAAG GAGGGGGTTC CCCTTCCCCG TGTGTCTCTC AGGTGGGCCA 26351 CCACACCACA CTGCTCTTCC TTCTCTCTGT GGGTCACTGC CAGCCTTCTA 26401 GTCAATTTTG ATGAGGGAAC CTGGACATTT TGGTTGCCAG GAAGGATCAC 26451 ACACTTATTA CAGTTTTTTT CAATGTGAGC CTCTGAGCGC TGCTGCTTAT 26501 AGTCGACCAT CTTGGCCCCC AGAGTCACAC ATCTGTTATT TTTTGATGTT 26551 TTGATTGTGG CAATTCTTGC AGAAGTAAGG TGGTATCACC TTATGGTTTT 26601 GATTTCCCTG GTCATTAGTG ATGTTGAACA TTTTTTTCAT ATGTTCATTA 26651 GCCATTTGTA TATATTCTTT CAACAACTGT CTATTTATGT CCTTAGCCCA 26701 CTTTTTGATG GGATTGTTTT TTTCTTGCCA ATTTGTTTGA GTTCGTTGTA 26751 GATTCTAGAT ATTAGTCCTT TGTTGGATAT ATAGATTGTG AAGATTTTCT 26801 CCCACTCTGT GGGTTGTCTG TTTACTCTAC TGACTGTGAA GGAAAAGTCA 26851 ATTTCTTATA CGAATTTGTC TCACTCCTAC TTCCAAATGA GATCCTGGGG 26901 TTTTTTTTTT CTGTTAATCC TTCACAATAC TTCTCCCACT TTTTTGAACT 26951 CATTTGTTTA TATTCTGTTG TCTGCTTCTC TTTTATAGGA ATGTGACTTC 27001 TTATGGGCTT TCTCTATTAT ACCACATATG GGTTTTTGTT TTGTTTTGTT 27051 TTGTTTTGTT TTGTTTTTGT CCTCGGATCC ATTCTCCAAC CTCCTCCAGC 27101 CTTCCCGTGC TCTGTGGGAT AGACGTCTGA CTCATGAAAA CTACATTTCC 27151 CAGGCTCCCA TGCTAACTAG CTTCCTGTTA GGTTCAGCCA ATAGGAGGCA 27201 TTGGTGGGAC AATGGTGGGC GGGGCTATGG AAGGGCCAGA GTATTTCTGT 27251 ACCCCGCCCC CCTGCTCCCC TTCCAATGTT CCTGGAGCGG TGTAGGACCA 27301 ATACTGTATA TATGGAAGGA AGGCAAGGTG GATAGATTGG AAGGAAGAAG 27351 TGACAGATGG AAAGAAGAAG TGATAAATGG CAAGCGAGGC AAGGGAGCAG 27401 AGGATGGATG AGTGGATTGC AAGAAAGAAA AAAATGGATG AAATATAAAA 27451 GGAGCAGGAC AGATGGATAA GTAGATGGAA GTAAGAAAAG ACTGGTGTAA 27501 GAAAGGAACG ATTGATGATG GATGATGAAT GGATCAGTGG TGATTGGGTG 27551 AAGGGATGAA TGGATGGATG GACAGATGGA TGAACAGATG GGTGGGTGGA 27601 TAGATGGATG GATGGATAAA ATGGGTAGGT GGATGGATGG ATGGATGGAC 27651 AGATGGGTGG GTAGGTGGAT GGATGGATAG ATGGATGGAT AAGTGAATGG 27701 ATGGATGGAT GGATGGATGG ATAAATGGAT GGATGGGTGA AAGGAAGGAA 27751 AGAAGTGAGA GAAGGAAGAG GAAGGATAGA CAGATGTTAG AAGGTACAAA 27801 TGAAAGGAAG GAAGCCAGCA AGAAAGAAAG GATGCATTAA TAGAATGAAA 27851 GATGGAAGGG AAGAAGAAAG GATGGAAAGA GAGAAGGAAG AATGAACAGA 27901 AGGAAGTTCA AGAGTGGTGA AAAGAAGAAA GGCAGGGAGA GAAGGAGAAG 27951 TAAACTTTTC TTCTAGAGAT TTGTCTTAAA CCTTAGCTTG GCTGGACACT 28001 GTGGTTCACG CCTGTAATCC CAGCACTTTG GGAGGCCGAG GCGGGTGGAT 28051 CATGAGGTCA GGAGATCAAG ACCATCCTGG CTAACACGGT GAAACCCTGT 28101 CTCTACTAAA AATACAAAAA AAATTTAGTC AGGTGTGGTG GTGCATGCCT 28151 GTGGTCCCAG CTACTCAGGA GGCTGAGGCA GGAGAATGGC ATAAAACCTG 28201 GGAGGCAGAG CTTGCAGTGA GCCAAGATCA CACCACTGCA CTCTAGCCTG 28251 GGCGACAAAG TGAGACTCTG TCTCAAACAA AAACAAAACA AAAAAACAAA 28301 AACAAAAAAC AAAACCAAAC CAAAACAAAA AAAAAAACCT TAACTCATAC 28351 TTTCATAAAG TTCCACACAC AGGGAGTGAT TAGAAAGCAT TTGCTGATAT 28401 ATTTTATATA ATAAACATGT ACACCATATT GACCTGTGTG CCCAGCAGTG 28451 CTTACATGAT TTACAATGAT TAACTTGTTT AAGCTTCATA ACAACGGTTG 28501 AGGCAGGAAA CATCATTGTG AACCATTGTC ATCTCATTTT ACAGATGAGT 28551 AAACTGAAGT GCTGAGAGGT TGGTTATGGC TGCAAAGATT GTTGGCCATG 28601 TTAACCAATG CATAGAAGAT TAGCATACCT GGTTGTGAGT GCAGGAGAGA 28651 GAGAGAAATG GGAGAAAGGC AGAGAAGGAT CGATGGGGAG AGAGGAAGAG 28701 AGAGAGAGAG AATAAATTTT TTAAAAATGT CTAGAGTCAT GACTTCCGCA 28751 TCAGTGTGGT AATATGCAGC CTTTACCCTG GGAAAGATCA GAACCATTGG 28801 TACTTTTTAC AGAATCTTCC CTTCCTGCAT TTGGGTAGAA GGACCCCATC 28851 TGGACATCCC AAATCATTAA GCACACCCTT ACTGGCTGCT GGAGTTGTCT 28901 CCATTAAAAG TCACCGTTGG GTTTATTAAG AGGCGGACAC AGGGTCCTTA 28951 GAACACACTG CCCCCACCTG TCCCACACCA CCCCCCACCC ACCCATCATC Exon R1 29001 CTCCCCAAGA GCTTCATCTC TCTCTCTCTT CCCCCTGCCC TAGCCGGGGT 29051 GGTCAGCGAG GAGCCATTCA CACTGAACTT CACCATCAAC AACCTGCGCT 29101 ACATGGCGGA CATGGGCCAA CCCGGCTCCC TCAAGTTCAA CATCACAGAC 29151 AACGTCATGC AGCACCTGGT GAGAGGCCTG CCTCCCGCTG CAGCCCTGCC 29201 ATGCCCATCC TAGGGCTGTT GCCTGCCTGC CTCTGACCAA CCCAAGCTCC Exon R2 29251 CTTCTCCCTC TGCAGCTCAG TCCTTTGTTC CAGAGGAGCA GCCTGGGTGC 29301 ACGGTACACA GGCTGCAGGG TCATCGCACT AAGGTGAGAA ACTCCCCCAC 29351 CCACAGCGCA CCACCAAGAA CTTAGAGTTC TGACTGGGAG GTCCCTCTTG 29401 GGTTGGGGTG GGCTACATAT TTTTTTAAAT CTTTTTATCT TTCCTTTTTT 29451 TTTTTTTGAG ATGAAGTTTC GCTCTCGTTG CCCAGGCTAG AGTGCAATGG 29501 CACGATCTTG GCTCACTGCA ACCTCTGCCT CCCGGGTTCA AGTGATTATC 29551 CTGCCTCAGC CTCCCCAGTA GCTGGGATTA CAGGCAGGCA CCACCATGCC 29601 TGGCTAATTG TTTTGTATTT TTAGTAGAGA TGGGGTGTCT CCATGTTGAT 29651 CAGGCTGGTC TTGAACTCCT GACTTCAGGT GATCCACCCT CCTCAGCCTC 29701 CCAAAGTGCT GGGATTACAG GCGTGAGCCA CCATATCTGG CCCCATTCTT 29751 TTTTTTTAAA TGAATTTAAG GAGTGCAAAT GCAGTTTTTG TTACATGCAT 29801 ATATTCCATA GTGAAGTCTG CAGACAGTAG ACTTCCAGAC AGTAGCTTCT 29851 GGTGTATCAC CCGAATAGTG TACATTGTAC TTATTAAGTG AGGTTCCCCA 29901 CCCTTCTCCC ACTCTCCCAC CTTTCTGAGT ATCCAGTGTC TATTATTCCA 29951 CACTCCAGGT CCATGCTCTC ACGTATAAGT GAGAACGTAT GGTATTCCAC 30001 CATGAGCTAA TGGACATGGA GTCCATTGGC TCCCACTTAT AAGTGAGAGC 30051 ATGCGGTATT TGACTATTTC TGAGTTTCAC TTAAGATAAT GGACTCCCAT 30101 TCCATCCATG TTGCTGCAAA ATACATGATT TCACTCTTTT TATGGCTGAA 30151 TAGTATTTCG TGGTATATAT ATATACCACA TTTTCTTTAT CCAGTCTTCT 30201 ACTGATGGAC ACTTAGGTTG GGTCCATACC TTTGCTGTTG AAATAGTGCT 30251 GCAATAAACA TACACGTGCA GGTGTCTTTC TTATATAAAT GATTTCTTTT 30301 TTTCTTTCCT TTTTTTTGAT ATAACGAATT TCTTTTATTT GGGTTAAATC 30351 CCCCAATAGT GGGATTGNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 30401 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 30451 TGACCTGTCC GTATTGATAT ATAAAATGCT GCATTTAAAG TGTACAACTT 30501 GATATTTTGG TATACATTGT TAAATCATGG CCACATTTCA GCTAATTAAT 30551 ATATCTATTA TCTCTACATA GTTATCATGT TTGTACCCTT TGACCAGCAT 30601 CACCCCATTT GCTCCTCCTC CCAGCCCCTG GCAACCACCA TCCTACTCTC 30651 TGCTTCTATG AGTCTGACAA TTTTAGATTC CACCTATAAG TTAGATTATG 30701 CGGTATTTGT CTTTCTGTGC CTGGCTTATT TCACTTAGCC TAATGTCCTC 30751 CAGCTCCATC TATGTTATCC CAAGTGGCAG GATTTTCATC TTTCTTATAT 30801 ATTTCATTGT ATATGTGTAT GCCACATTTT CTTTACCCAT TCATCCATTG 30851 AAGGTCATTT AGCTTGTTTC CATATCTTGG CTATTTTGAA TAGTGCTGCA 30901 ATGAACATAG GAGTGCAGAT ATCTCTTTAA GATACTGGTT TCATTTCTTT 30951 CTTTCTTCTC TTTTTTTTTT TTCTGAGACA GAGTCTGACT CTGTCGCTCA 31001 AGCTGGAGTA CAGTGGTGCA ATCTTGGCTC ACTGCAAACT CTGCCTCCTG 31051 AGTTCAAGCG ATTCTCGTGC CTCAACCTCC CAGGGAGTTT TGCTCTTGCT 31101 GCCCAGGCTG AAGTGCAGTG GTGCAATCTT CACTCACCAC AACCTGTGCC 31151 TCCCGGGTTC AAGCGATTCT CGTGCCTCAG CCTCCCAGGT AGCAAGGATT 31201 ACAGGCGCCC AACACCACAC CAGGCTAAAT TTTTTTGCAT TTTTAGTAGA 31251 GACGGGGTTT TGCCATGTTG GCCAGGCTGG TCTCAAATTC CTGGCCTCAA 31301 GTGATCCACC TGCCTCAGCC TCCTGAAGTG CTGGGATTTT ACAGGCATGA 31351 ACCACCACAC ATGGCCTCAT TTCTTTTAGA TATATATGGG TTGAGCTATT 31401 CTCAGAGGGT CCTTTTCTGC ATCTATTTAA GATCACATTT TTTTTATATT 31451 GTGGCAAAAA TACATGTAAC ATAAAATCTG CCATTTTAAC CATTTTTAAA 31501 TGTACAATTC AGTGACATTG ATTATATTCA CAATGTCATA CAGCCATCAC 31551 CACTATTTAT TTCTAATACT TTTCCATTGG GTAGATCCCC AACAGTGGGA 31601 TTGCTGGGTC AAATGGTAGT TCTGATTTTT TTTTTTTGTT TTTTGAGAAA 31651 TCTCCATACT GTTTTTCATT TGAGGTTGTA CTAATTTACA TTCCCACCAA 31701 CAGTGTATAA GAGTTTCCTA GGCCGGGCAT GGTGGCTTAT GCCTGTAATC 31751 CCAGCACTTT GCGAGGCCCA GGTGGGTGGA TCATGAGGTC AGGAGATCGA 31801 GACCACCCTG GCTAACATGG TGAAACCCCG TCTCTACTAA AAATGCAAAA 31851 AATTAGCCGG GCGTGGTGGC GGGTGCCTGT AGTCCCAGCT ACTGGAGAGG 31901 CTGAGGCAGG AGAATGGCAT GAACCCTGAA GGCGGGGCTT GCAGTGAGCT 31951 GAGATCGCAC CACTGCACAC TTCAACCTAG GCGACAGAGC GAGACTCCAT 32001 CTCAAAAAAA AAAAAAAAAA AAAAGGTTTC CTTTCAGTGC ATCCTTGCCA 32051 ACTTGAGTTT TCTGGGTTGG TTTGCACTCT CATGGTATTT ACTAGATACT 32101 TCTCCATTTA TATTTTTACT CAACCCATGC CCATAACACC ACTCCTCTAC 32151 CATTCCCACC AACCATGTAT AAGAGTTCCT TTTCTTGCAT CCTTGCCAAC 32201 TTGACTTCTT TGGGTCAGTT TGCACTCTCT TGGTATTTAC TATTTACTTC 32251 TCCATTTATA TTTTTAGTCA ACTGATGCCC ATGGCACCGC TCCTCTGAGG 32301 CAGGTGCTGG GTACTAGAGT GATAAGACAG ATGCTGTCCC TGCCCTCACC 32351 CAGTGGAGAA GAACAGATGC TAAACAGGAA CATAAATATC TAAGTAAAAT 32401 GGCTTCAAAT GGAGTAAAGT GATATGAAAC ATAAATAAAT AGCAAGTGAT 32451 GGGTAGAGCA ACTTTACCCA GGATGAATCT TGGGCTGTGT CCCAAATGGC 32501 CATGAAAACT GTTCCAGGCA GGGAGAACAG CATGAGAAAA GGTCTTGAGG 32551 TGCAAATGAG CTTGGCATGT TCTATGAACA GCAAAGAGGC CAGTGTGGCT 32601 GGAGCAGAGA GAGAGCAAGA AGAAAAGAGA GAAAGGATGA GACTCAAGAC 32651 ATCAGCAAGT TTGAAGGGCC TTGGAGGACT TGGATTTTTT TTTTTAAGAC 32701 AGCTTTGTTC TTGTTGCCCA GGCATGATCT CGGCTCACCA CAACCTCCGC 32751 CTCCTGGGTT CAAACGATTC CTCTGCCTCA GCCTCCCGAG TAGCTGGGGG 32801 TAACAGGCAT GTGCCCACCA CACCTGGCTA ATTTTGTATT TTTAGTAGAA 32851 ATGGGGCTTC TCCATGGTTG GTCAGGCTGG TCTCGAACTC CCGACCTCAG 32901 GTGATCCGAC CGCCTCGGCC TCCCAAAGTG CTGGGATTAT AGGTGTGAGC 32951 CACTGCACCT GGCTTGGATT TTTTTTGTTC TATATTGTGG TAACATACAC 33001 ATCACATTAA ATTGATCATT TTAGCTATAT TTCCCGTTCA GTGGCATCAA 33051 GCACATTCAC ATTATTGTGC AACCATCACC ACTATCATCC ATCTCCAGAA 33101 CTTTCTCATC TTCCCAAACT GAAACTCCAT CCCCATGAAA CACTCATTCC 33151 TCATCCCCCT CCTCAAGCCT CTGGCACCCA CCATTCTACT TTCTGTCTCT 33201 GTGAATCTGA TGATTCTGAG GACCTCCTAT GAATGGAGGA ATCATATGGT 33251 ATATGTCCTG GTTTATACTG TATGGCTGGC TTATTTCACC AAGCATAATG 33301 TCCTCAAAGT TCATCCATGT TGTAGCATGT GTCAGAATTC CCTTCCTTTT 33351 CCACTTGTAT GTAAATGCTG TATTGTGTTT CTCCATTCAT TAGGACTTTG 33401 ATTTTTGCAG GGAGTTGTCA AGGGGTGCTG GGTTCTGGGG CTTCAATATA 33451 ATAAGAGTAA GCTAAACTGG TTCATTTCCT CCTTCGTGGA GACCATGTTC 33501 TGGTAGGAAC AGGAACAAAT AATTTATGAT TACATAGAGG GTGACCAGGG 33551 CAGTGACAGG GGAAGAGTGG AGGATTGTGG GACCCAGAGG AGGCTCCTGA 33601 CCTTGCCTAG GAAGATAGGA GGAGGAAGAG GAGGAGGAAG AGGAGGAGGA 33651 AGAGGAGGAG GAGGAGGAGG AGGGAGTCCT CTAAGCTGAG ACCTGGAGGA 33701 TGACCAGGAA GTTATCCAGG TAAGGAGAAA TGGGGAGAAG CTTCCAGACA 33751 AAAGTAACAG CAATTGCAAA GATCCTGAGA TGATAGATAA GGTCAGGTGG 33801 AGAAAGTGCA AACTGTCAAT GAGACCAAAA TATGGACTGT GAGTTGTGCA 33851 GTGACCACAA GTGGAGAGGT GCTAGGTGGC CTTCATCCCC CAAAGCTGCA Exon R3 33901 CCTCTCCCTC CTCAGGTCTG TGAAGAACGG TGCTGAGACA CGGGTGGACC 33951 TCCTCTGCAC CTACCTGCAG CCCCTCAGCG GCCCAGGTCT GCCTATCAAG 34001 CAGGTGTTCC ATGAGCTGAG CCAGCAGACC CATGGCATCA CCCGGCTGGG 34051 CCCCTACTCT CTGGACAAAG ACAGCCTCTA CCTTAACGGT GAGCAGCTAT 34101 CAGCCCCATC TCCCTGCCCC ACCCCCCAGC CCCCACTGCA GTCCAGGAGG 34151 GTGTCTGTTT GCCGGTTCTC TAGGGAAAGA CTTGGGGTTC AAGTCTTGGC 34201 ATTACCACTG GCCCTCCCAT AACCACAATG CAAGGTTGGA CTTTGATTAA 34251 TCCCATTTTA CAGATGAAGA AACTGAGGCT TAGACAGGCT AAGCAATTTA 34301 CCTTGACAGT GGTGGAACCA GGATATGAAC TCCACTTGTC AGCATTCGGT 34351 GCTATGATCC ACTCCACATG TTTAACTCAC AGAAGAGTCT TCCTGGTGGG 34401 GGCACTTGGG GGACAAAAAA CACATTTCCG GCTGTGAGCA GTGGCTCACA 34451 CCTGTAATCC CAGCACTTTG GGAGCCCAAG GCGGGCGGAT CACAAGGTCA 34501 AGAGATTGAG ACCACCCTGG ACAACATAGT GAAACCCTGT CTCTACTAAA 34551 AATACAAAAA TTAGCTGGGT GTGGTGGCGC ACGCCTGTAG TCCCACCTAC 34601 TCGGGAGGCT GAGGCAGGAG AATCGCTTGA ACTCGGGAGG CAGAGGTTGC 34651 AGTGAGCCAA GATTGCGCCA TTGCACTCCA GTCTGGGTGA CAAGAGTGAA 34701 ACTCTGTCTC AAAAAAAAAA AAAACAATTT CCCCTCCCTG CTTTCTTCTC 34751 ACCATTGACG AGGGATGGGC TTCTCTCCTA CCTGAGGCCC CCTATACCAG 34801 GAAGATCTAT GGGATCTAAT CTTCAGCGCA CACTGGGCCT CAGCATTGGT 34851 CTAGAACTCA GGATAAGATA GCATTTAAGA AGGCATCCCC TAAATGGGGT 34901 TCTGAGAGGC AAAGCATGAC CGTGGAGAAT TGACAAAATA GCTCGCCTTT 34951 CATCCCCTCC ACCGCCAACC CAAGAACAGT GCTTATCATC ATGACCCCAT 35001 GAGGTGGGCA CCCCATATCA CTTATATGAG GTACCTTTAG GTAGGTACCG 35051 GGATGTGGAG AGACATCCTG GGCTTTCATT ACTCTTATTT TAGCAAAGAG 35101 GGAATCTGAG GCACAGAGAA GGGAAGGGAC TTGCCCATGC CCACAGCGAG 35151 TTTTTGGCTA GTATGGGTCT TGATGTTCTT TCTGGGTCCG TNNNNNNNNN 35201 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 35251 NNNNNNNNNT TCCTGCGTGG GAGATGTGTG GATTTGATTT GTATCTGGAA 35301 AGATGATTTT TTATTGGTGA CAAAGCAGTT AAAGTTAATC TTCACAGTTG 35351 TGCGGAGAGT GACCACGCGA GTTAGTCTTA TCCTTATTTT TTTGATCATC 35401 CCGCTACACA AGACAAAGCG AACCGCACAG GCAACATCAG CAGGCCCCAT 35451 TGGTGTGTTC CCCTCTATGG GTCCATGTGT TCTCATCATT AGCTCCCACG 35501 TATAAAGTGA GAAGATGGCA GTATTGGTTT TCTGTTCCTG CATTAGTTTG 35551 GTAAGGATAA TGACCTCCAG CTCCAACCAT GTTCCTGCAA CGGACATGAT 35601 CTCATTCTTT TTTATAGCTG CATAGTATTC CATGGTGTAT ATGTTCCTCA 35651 TGTTCTTTAT CCAGTCTATC CTTGATGGGC ATTTAAGTAG ATTCCATGTC 35701 TTTGCTATTG TGAATAGTGC TTCAGTGAAC AGGTGTCTTT ATGATAGAAA 35751 AATTTATATG CCTTTGGGCA TATATGCAGT GATGAGATTG CTGGGTCAGA 35801 CGGTAGTTCT GTTTTTAGCT CTTTGAGGAA TCATCCTGCT GCTTTCTACA 35851 GTGGATGAAC TAATTTACAC TCCCACCAAC AGTGTATAAA CACTCCTTTT 35901 TATCTGCAAC CTCAGCAGCA TGGTTTTATT TCTCTTTATG GCTGAATAGT 35951 GTTCCATTGT GCATATATAC CACACTTTCT TTATGGATTC ATCTGCTGAT 36001 GGACATATAG GTTGATTCCA CATCTCTGCT ATTGTGAATA GTGCTGTGAT 36051 AAACACACAG GTGCGGGTTG GGTCTTGATG ATCTCAGTTA ACATCCAGTC 36101 CCTTCAACTT GGCTATTGCA GGGAGCTGTT CCCCCTTGTA AACTGCACAG 36151 CTTATGTGCT TCATTTTGTT CCTTCATTTA GATTTACCAA GCAGCTACTA 36201 TTAACCAGGC CACAATGTGC CTCGCCCCCA GGAACAGAGA TAGGTTACAT 36251 GTGCATCCTG TCCTAATGTA ATCTCCAGGG GGGCGGAGAC TGTTTTGTTC 36301 TACCCTATAT TCCCCAAATG TAAAGGGAGC CTTGCACATA CTAAGCCCTT 36351 AATAAACATT CATTGGGTGG AGGAATAGAT TGGAGGAGGC CTGGAAGGGG 36401 AGGCGGGGGT TATGGATGGA TAGGAGGATA GACTTGTGAA CACAAAGGTA 36451 GTGAGAGCCT CTCATTGGAG GCATGCTGGA GACGTGAGTA GGGAAGGGTC 36501 AGTGCTAATT GAAATATCAG GAAATTCTTT CTAGTGGTGA ACACATTTAA 36551 GTCAAATATT AGATGATACA TAAATGTATC CATAATCTCT AGATACACAA 36601 AGGGAAAGGC ATCCAGGCAG GGGCCCCATA TGGACAAAGG CATGGAGTAT 36651 CTGGGACGGT TCCACCACCT CCTCTTACGT GTGACTTCTT TGTTTCAAGG Exon R4 36701 TTACAATGAA CCTGGTCTAG ATGAGCCTCC TACAAGTACG TGTCTTTGAA 36751 TCTAGTGCCC ATTTCAATCT CCATGGGTCT TGGTTCAAGC TTTTCTCCTC 36801 ATTCATGAAG GAAGGTTGCC CCAAATTCGG GCTGGTCCCC TAGGTGGTGA 36851 GGGGCATTGT CTCAGTGGGA GGAAGAATGC TGAGTCCTTG GCCCTGTTTT 36901 TAGACCTGCA GCCATAGTCT TGGCTTTGTG AATTTTCCAT GTCCCTCTGG 36951 GTTGGAGGAA GAAGTTTGAA CAAGCATTCC CTACACGGGA TAGAGGTTGA 37001 GGTCAGATGA TGACCTCTGT TAGTCTGTAC CCTCCTTGAT AAGAAAATCT 37051 CCTCCAAGTG CCCCAGCAGA GGCTTCATGG TCAAGCTGCA GACTCTGCTG 37101 GCTACTGGTT TTGGCTAAAT TTGCCCATTG CCTCATCCAG TGATCCACTC 37151 GTCTATCTTT CCAGCCATCC ATTTTTCTAT CCTTCCAGTC ATCTCTCAGA 37201 CACCACCTGT CCTTCCATCC ATCCATCCGT CCATCCATTT ACCCATCCAT 37251 CCATCCACCC CATTTTCCTG ACCATTTACC TCCTCGTCCT TCCTTCCATC 37301 TGTCCTTTTA TCCATCTATT CATCCATCAC CCATCCTCCT GCCCATTCAC 37351 CTGCTTGTCC CTCCTTTCTT CTGTCCTTCT ATACATCCAT CCATCCATCC 37401 ATCCATCCAT CCACCCATCC ACTCATCCAC CACCCACCCA TCCTTCTGCC 37451 CACTCACTCG CTAGCCCCTC CTTCCTTCTG TCCTTCCATC CATCCATCCA 37501 CCCATCTTCC TGCCCATTCA CCTGCTTGTC CTTCCTTCTA TCTGTCTTTT 37551 ATCCATCTCT CCATCCATTC TCACCATCCA TCCATCCATC CTTCTCCCTA 37601 TTCACTGGTT TGTCTTTCCT TCTGTCCTTC CAACCATCCA CCCATCTCTC 37651 CATTCATTCT CCTCTTCATT CACCATGTTT CCTTATTTCT GTCTCTTCCA 37701 TCCATCCATC TATCCAGACA GACATCTCCT CCCCCCATTC TCCTCCCCAT 37751 TCACTCAATT GTCCTTCCTT CCATCTGTCC TTTTATCCAT CCATCCACCC 37801 ATCCATCCAT CCATCTATCC TTCTCCCCAT TCACCTGTTT GTCCTTCTTT 37851 CTGTCCTTCC AACCATCCAT CCATCCATCA TCCATCCATC TATCCTTTTC 37901 CCCATTCACC TGTTTTGTCC TTCCTTCTGT CCTTCCAACA TCCCTCCATC 37951 TCTCCATCCA TCCTCCTGCC TATTCATCTG CTTGTCTTTC CTTCCTTCTG 38001 TCCTTCCATC CATTCATCCA TCTGCCCATC CACCCACTCA TCCTCTTGCC 38051 CATTCACCTG CTTGTCCTTC CTTCCACCTG TCCTTTTATC CATCCATCCA 38101 TCCATCCATC TTGCTCACTC CTCCACTCAC ACAATCACTC CTTCCCTCAG 38151 TCTCATTTAT GGCCCACCTG TGAATGGTTG TCCTGGCTTG GACCACTGAT 38201 GAAGCCCAGG GGAGCTTCTC CCACTAGTGG TGGGCTTTTG TCCTCTCTGA Exon R5 38251 TGGACTGTTC CTTCCACAGC TCCCAAGCCA GCCACCACAT TCCTGCCTCC 38301 TCTGTCAGAA GCCACAACAG GTATTTGGGG CCATTTTTCC TCCTCGAAGA 38351 TTAGAATAGC ATTTCAATCA GACACCTGCC CTCGTGGAGT CCCAGATTTT 38401 ATGAAATAAA TAGACCATCA TAATGTCAGA TGTTTTGGGG TGAGATACCT 38451 GGCATAGTTG GGAAGGAGGA GGGCTTTCTG GAGAAAGTTT CACCTGAACT 38501 GAGTCTTTAA GGATGACTAA GAGTGATTCA GGCAAATAGG GCATGAATAG 38551 TATAACTGAA AGAGGGGAAT CTGTGAGCAA AGCCTCAGTG GCCAGAAACA 38601 GCATAGAGTA TAGGGAGAAG TGAGAGAAAT TTGGTTTGCA TGAAACATAA 38651 AGCTTAACCC AGAGTGGATG GATAAGTGAG ACTGAAAGGT CAGCAGGAGC 38701 CAGATTGGGA AGGGCCTTGA ATGCCAAGTC AAGAAATTTG AACTTAACAC 38751 TGAAGGCCAT AGGGAGCTGT GGATGGTACT AGAGCAGGGG CAGCCATAGT 38801 GAGATTGTCA TTTCAGAAAG ATTCTTCTTG TGTTCAGTAT AGAGAATGTC 38851 CTTTAGACAG GGCATCCAGT GAGTCTGCCA GGTGCTAATC AGGGTGAGAG 38901 AAAATAAGAC CTGAACTGGG ATAGGGGGAG GAGAGAGAGG ATATATGTGA 38951 TGAATATTCA GTAAAGAGAA TTGGTGTTAC TTGGAGGGGA GAAGACACAT 39001 AGCTTCTGAC TTGCGATGGC CACACTCAGT TTAATAATGA GCGCAGTCTG 39051 ATCTAGTCTC AGACCAGCCC TCAGTTGCAG ACGTCTCTCC TCCCCTCCTG Exon R1 39101 CAGCATGGGG TACCACCTGA AGACCCTCAC ACTCAACTTC ACCATCTCCA 39151 ATCTCCAGTA TTCACCAGAT ATGGGCAAGG GCTCAGCTAC ATTCAACTCC 39201 ACCGAGGGGG TCCTTCAGCA CCTGGTGAGA CCCTGGTCCC AGCAGCTCCT 39251 GGTGGGATAA ATCCTACCCC CAACCTCTGT TCCTCGGCTT ACCCTCTTCC Exon R2 39301 TCCTTCCTCT CAAGCTCAGA CCCTTGTTCC AGAAGAGCAG CATGGGCCCC 39351 TTCTACTTGG GTTGCCAACT GATCTCCCTC AGGTGAGACC ACTTCCTGGC 39401 CATTTGCCAG TAACAACCAC CCCTTTTGTG ACCACCCCTT CCTCAGCTTT 39451 CCCCTGCTCC TCCCTCCACT GCTCTTTACC TGCAGAGGTC TCGGGACCTC Exon R3 39501 TCTAGAGTCC TCAAATGCCT CTCTCCCCAG GCCTGAGAAG GATGGGGCAG 39551 CCACTGGTGT GGACACCACC TGCACCTACC ACCCTGACCC TGTGGGCCCC 39601 GGGCTGGACA TACAGCAGCT TTACTGGGAG CTGAGTCAGC TGACCCATGG 39651 TGTCACCCAA CTGGGCTTCT ATGTCCTGGA CAGGGATAGC CTCTTCATCA 39701 ATGGTGAGTG TCAGGCTGAA CTTGGATTTA CAGTGACTTT TGGGGAGTTG 39751 GTTTCTTTGT TTTTGAGATG GAGTCTCACT CTATCACCCA GGCTGGAGTG 39801 CAATGGTGCA ATCTTGGCTC TGCAACAGTG ATTCTCCTGC CTCAGCCTCC 39851 CAAGTAGCTG GGATTTACAG GTGCATGCCA CCACGCTCAG CTAATTTTTG 39901 TATTTTTAGT AGAGATGGGG TTTCACCATG TTGCCCAGGC TGGTCTCGAA 39951 CTCCTGACCT CAGGTGATCC ACCTGCCTTG GCCTCCCAAA GTGCCAGGAT 40001 TACAGGCATG AGCCACCATG CCCGGCCCAC CATGACTATT ATTTGTCCCT 40051 GTTGTATGCC CTTTCCTCTC TAAAAAAAAT AGCCCAAGGC CTGGCTGGGG 40101 GACACCCTTC CCCAAACCAC CAAGGGGAGG GTCTTTCCCA TTATTTTGAG 40151 TAAATAGCAT GAAATTCTTT GACCAAATTA ATGTCATAAA TTGTTTGTCT 40201 CTTTCTCCTT CACTTTTGTT TCCAACTTGG TTGCGGTATA ACTATCAAAT 40251 ACAATTGTAT GTATTTAAGA TGTATAATGC AGTGATTTAA TATATGTGTA 40301 GCTTATGAAA TGATTACCAT GATCAAATTA GTTAACACTG CTTTCATGTC 40351 ACATAGTTAC CGTGTGTCTG TGTGCGTCTG TGTGAGTTAG AGAGAAAGAG 40401 AACATTTAAG GTCTACCCTC ATAGAAAATT TCAGGTTTAC AATACAGTAT 40451 TATTAACTAT AATCATCAAG CTTTATACTC GATCCCCAGA ACTTATTCAT 40501 CTTGTAACTA AAAGTTTGTA TTTTGTGACC AACATCTCCC CATTTTCTCT 40551 ATCACCACCC CCATGCCCCC AGCCCCTGAT AACCATCATG CTACTCTCTG 40601 CTTCTGTAAG TTTGACTTCT GATCCCACAT ATAAGTGAGA TCATGCAGTA 40651 TTTGTTTCTC TCTATCTGGT ATATTTCACT TAGCATAATG AACCCCCCCC 40701 AGGTACATCC ATAATGAATT TCAATTCAAA ACCCAAGTGG CTGAGTCGTG 40751 GCATCCTTTG GGACAGGATA GCAGGTCCCT TCTATATAAG GATCCTCTGT 40801 GTCAGTGGTT ATTACCAGGG GACAATTCTG CACTTCTGCC CCACCCCACC 40851 CCCCAACTGG GAGACTCTAG GCAATATCCG AAATCATTTT TGGGTATCAC 40901 AACTCAGGGA GGGAAGGAGG GTGCAACTGG CACCTAGTGG GTCGGTAGCC 40951 CATTTTCCAG TGCACAGGAG ACAACCACCC CAGGGAATGA TCCAGCCCCA 41001 AATGCCAATA ATTTCAAGGG TGAGAAATCC TGTTGTACAT GGTCTCAAAG 41051 TTCTTAGGTG GGCACAAGGC TGACATTTAT CACACTTTAC TGTAATTACT 41101 TGTTAAATTT ATCTGATTCC CCCTTACCCT GTGAACTCAA CAAAATTACG 41151 GTCTATTATG AGTGCCACTG TACCCTCGGT TCGCAGTACA TCAGCACATC 41201 ATAGTATGGA AAGAATCATT GAATGAGTGA GCAAATTAAA GATTTGTGTC 41251 TCTGCTGTAA CTCACATTCA TTAATTCATT CATTCAGCAA ACATATATGG 41301 GTGGCTGTTC TGCCCCAAGC CTTGTACTGG GTCTGGAGAT AGAAGACACA 41351 TTTTTCTGTC TCTGAAAAAC TCATACTCAA GTTAACAACA AATTACGGGC 41401 ACAACAAAGA CCCCACTGCT GTTATTAACA GGGTACTATG GGAGCTGAGA 41451 GGAGGAGTAA ATTAAGGAGG GCTTCCTGGA GGAGGGTGTT ATATACCCGG 41501 CCCTGTGCCG GGACACATAA TGATAAGACA GACTTGGGCC TCTGCTGTCC 41551 TGGAGCTCCC TCTCACTGGG CTCTTGAAGC GTGAGCAGGA GTTTTGCAGG 41601 AAATGAAAAG GATGCATTCC TAGAAGTGGG AACTGCATAG CACATGCAGG 41651 AAAGCTCAGC TCAGAAGAAT CTGTGTAATA TTCCATTTTT CCCTCTCTTT 41701 GGGGCAACTT TCTGTCTAAG AGCTCCTGCA ATGCCCAGCG TGTGGACCTG 41751 AAATTGATTC TGACAGTAGG CAGGGGACTG CTGGGCAACT TTGGCTCTGC 41801 ATTTTGTGAT CAACATTTCC CCACCATATG TTGCCTTTTC TTCTTCTCTG Exon R4 41851 TGGCTCCAGG CTATGCACCC CAGAATTTAT CAATCCGGGG CGAGTACCAG 41901 ATAAATTTCC ACATTGTCAA CTGGAACCTC AGTAATCCAG ACCCCACATC 41951 CTCAGAGTAC ATCACCCTGC TGAGGGACAT CCAGGACAAG GTGGGGCATC 42001 TCTCACCCCT CCCGTCTTCT CTGTCCTGTG TGCTTCTCTC CCTCTTCTAC 42051 CTGATTTCTC TGTTAAGTGA TCACTTTAAA TGCTTCACTT CACTATGTAT 42101 TCTGGGTTCT CTCTCAGTTT CCAAAAGTAC TCTCTTGACT ACCATTCCCA 42151 TTTCACAGAT GGGCAAACTG AGGCTCAGAA AGGGGCGTGG TGTGCCTAGG 42201 GTCATACAGT GCTTTAGGAA CAGAGTTAGG ATTTGAACTC TGGTCCCCTT 42251 TGCTCCAAGT CCTGTGTTTT TTTCCACTGG CATCAGCGGC CCCTCCACCC 42301 CCAAGAGGCC TCCATCTCAC CCACTCTCCC TACCCATCTT TCTAGGTC

[0055] 3 Table 3 Genomic Carboxy Terminal (SEQ ID NO:3) Exon C1 1 ACCACACTCT ACAAAGGCAG TCAACTACAT GACACATTCC GCTTCTGCCT 51 GGTCACCAAC TTGACG TAAG TTCTGAAGGT CATAAGCAGT GACCAAGCTT 101 GTGGCTGTGT CTCTGAGCAC CCTTGAGCTA GACGTCCCCA GTGGGGTACC 151 CATTCTCCCC TACATCCCTG TCTAGCTAAT CCTACCATCT CCTCCCATAA 201 ATCCTCAAGG TAGGGAGTGA GGATTAACCT CATGGGGCCA CCAACTCCCA 251 GCATACACCT TCTTTTTTTT CTGGACACTT GGGAPAATAT AACTTTTTGA 301 TGTAGAACTC AAAATATTAG CCCAATAATA ATATTTAACA TCAACCAGCC 351 TCCTCTCATT TAATTCTCAC AACAGAATCT ATGAGTTGAG TGCAAAAATC 401 ATCCCTATTG TGCAGATGGG AAAACTGAGG GTCAGAAAAG TGAACTTCCC 451 AAGAACTGTC AAAGTTGGGA TTTGAACCCA GGTCTCTGAT GACTGGATGA 501 AGGAATGAAG ATACCTATAC TTGGGAATGA GGAGGGTCGA CAGGACACGA 551 GGGCTGACTT TGTATATTTC TAAACTTCAA AGATTTTCTG TATTTCAGCT 601 GGGAATATGG TAGAAGGTTA ATTGGAACAA AAAAATGCAA AGCAATGAAT 651 AAGACCTCAG TATTTGCTAT GCACAACAGG GTGACTGTAG TCCCACAAAT 701 AACTTCACTG TACATTGTTA AAATATAACT AAAGGTGTAT GCTTGGATTG 751 TTTGCAACAC AAAGGATATA TGCTTGAGGG GATGGATACC CCATTTACCC 801 TGATGATTAT TATGCATTAC ATGCTTGTAT CAAAACATCT CATATACCCC 851 ATAAATATAA AAACACCTAC TATGTACCCC AAAAAATTAA AAACAAATAA 1051 AGGCATGGTG GCACACACCT GTAGTCCCAG CCACTCAGGA AGCTGAGGTG 1101 GGAGGATCGC CTGAGCCTAG GAGGCTGTAC TCCAGCCTGG GTGACAGAGC 1151 GAGACTCTAT CTCAAAAAAT AAAATAAAAT AATAAAAAGT AGAAATCAAG 1201 AGGGAAAATG TGGGAGAAAT TGGGATAATT TTAACAATAC CTTCCACCAG 1251 AGTGATGATG AAGAATGCAT AAGTCACTTC TTAGTGGTCT TGATCTATAA 1301 AAAGTGTTCA ATAAATATCG ATTATTGTTA CTGTTATTGC TTCTAGACGT 1351 AATTCCTGGA AGCATTTTTT TTTTTTTTTT TTTTGAGATG GAGTCATGCT 1401 CTGTTGCTCA GGCTGGAGTG CAGTGGTATG ATCTCGGCTC ACTACAACTG 1451 CCTCCTGGGT TCAAGCAATT CTCCTGCCTC AGCCCCCCAT GTAGCAGGGA 1501 CTACAGGCAT GCGCCACCAC ACCCGGTGAA GTTTTGTATT TTTATTAGAG 1551 ACAGGGTTTT GCCATGTTGG TCAGGCTGGT CTCGAACTCC TGACCTCAGG 1601 CAATTTGCCT GCCTCGGCCT CCCAAAGTGC TGAGATTACA GGCTTGGGCC 1651 ACTGCATCCA GCCGAAGGCC TCCCATTTTG ATCAGAACCC TTCTCTAGAC 1701 TGAGGGTGGG TGCCTCTAGA TCTTTTGCTC TTTAAAGACA GCAACCGATG 1751 ACCCTGCTGA TGCTGAGTAC TGGCTGAATT CCTGTGGTCT CTGTCCCTAG Exon C2 1801 GATGGACTCC GTGTTGGTCA CTGTCAAGGC ATTGTTCTCC TCCAATTTGG 1851 ACCCCAGCCT GGTGGAGCAA GTCTTTCTAG ATAAGACCCT GAATGCCTCA 1901 TTCCATTGGC TGGGCTCCAC CTACCAGTTG GTGGACATCC ATGTGACAGG 1951 TACAAGGTGG GGTGGCTGGT TTCCTAACTG GAAGAGGTGG GGTTATGAGG 2001 AAAGATGGGG CTTCTCGGTA CCAGTGGAAT TGGTGGAGGC TCTAGAGAGG 2051 GAAAGGGAGG CTTTCTGGAG ACCCATGTAG GTGACCTCTG GCAGTAGATC 2101 ATCCAACGAG GCAGGAACAG AACACCAGCC ATTGCATCTA AGAGAATAGC 2151 TATTTTTACA TGTAAAAAGA ATTGTGTTGA ATGAATGAAT CAATAGATCA 2201 TTTATTTTGA ATCAATTTAT TGATTCATTC ATTTAATTAA TGAATAATAA 2251 ATGATTCAGT ACATAATTGA TTAATTGATG TAATTGAGAA TTGATTTAAT 2301 TGATTAATTG ATCAATTAAA ATGATCAATT AAATGAATGA ATCAGTAAAT 2351 GAATAATTCA TTCATTCAAT AAACAATGGA AGTAGGCCGG GCATGGTGGC 2401 TCACGCCTGT AATACCAGTA CTTTGGGAGG CCCAGGCAGG CAGATCACGA 2451 GGTCAGGAGA TTGAGACCAT CCTGGCTAAC ACGGTGAAAC CCTGTCTCTA 2501 CTAAAAATAC AAAAAAAATT AGCCAGGCAT GGTGGTGGCC ACCTGTAGTC 2551 GCAGCTACTC GGGAGGCTGA GGCAGGAGAA TGGCGTGAAC CCGGGAGGCA 2601 GAGCTTGCAG TGAGCCGAGA TCGCGCCACT GCACTCCAGC CTGGGCGACA 2651 GATGGAGACT CTGTCTCAAA AATAAATAAA TAAATAAAAA TAAAAAATAA 2701 ATAAACAATG GAAGTAAACA CGTACTGATA ACACAGTGTG ATCATTGCTA 2751 TGATAAGGGA ATTTCAGGGG CCTGTGGGAG CCCCAAGGAG GAACACACAA 2801 CCTTGTCTTG GAAAGTTTTA TGTAGGAAGG GGTGAAGAAG CTGAGATCTG 2851 ACAGAGAATG GGACCTAGCC AGGGGTAATA GATGGAGAAT TGTGCTCCAT 2901 GCATCTATAA CCTAGAAGAT AGAAAGAATA TGGCATCTGG CCGGGTGCGG 2951 TGGCTCACGC CTGTAGTCCC AGCACTTTCA GAGGCTGAGA TGGGTGGATC 3001 ACCTGAGGTC AGGAGTTCAA GACCAGCCTG ACCAATATGA TGAAACCCCA 3051 TCTCTGCTAA AAATACAAAA ATTAGCCAGG CATGGTGGTG CGTGCCTGTA 3101 ATCCCAGCCA CTTGGGAGGC TGAGAGAGGA GAACTGCTTG AACTCGGGAG 3151 GCGGAGGTTG CAGTGAGCCG AGATTGTGCC ATTGCACTCA AGCCTGGGCA 3201 AAAAGAGCAA AACTGCATTT CAAAAAAAAA AAAAGTGGCA TTTTGGGGCA 3251 AGTTTAAGAA GATTGGTGTA GCTGGAGCAT CCACTTTGAT ACTGGAGAGG 3301 TGACAGTTGA AGCCAAAGAT GTGGGCAGAG ACTTTGTTGG GCACTGGAAT 3351 GGCTTGGGGA GGAACATGAC ACACTCATGA GTTCTGCTTT AGAAAGAAAA 3401 TGAAATGAAT TCTGCTCATC CTCTGGGTGC TGTGTGCAGA ATGGAGGGTG 3451 GGGGGAGAGA AGAGCAAAGG CAAGAAGACC CTTTAGGAAC AATGATCATT 3501 AGTTAGAAGA CTCTGGGTTT CTCAGCACCT GCAATTGCTG ACTACACCCC 3551 CAGAGAAACC CAGTCTCTTT TCCCCCATGT TGTAGAGAAT TCTTACAATG 3601 CTTGGTAGAA AGAGAATTGA ACAGGTAGAT GGGTGGATGG ATACAAGCTG 3651 GACAGATGGA TGGAGGAAGA TCCTCCATCC AATATAGAGC TGTTACCTAA 3701 AACCCTCCAT CCCACCTTTA AAATCCTAGC TCAGCCAGGC GCGGTGGCTC 3751 ACACCTGTAA TCCCAGCACT TTGGGAGGCC AAGGCGGGTG GATCACTTGA 3801 GGTCGGGGGT TCGAGACCAG TCTGACCAAC ATGGTGAAAC CCCCTTCTCC 3851 ACTAAAAATA CAAAAAAAAA AAAAAGTTAG CCAGGCAGGG TGGCGCATGC 3901 CTGTAATCCC GCTACTCGGG AGGCTGAGGC AGGAGAATGG CTTGCACCCA 3951 GGAGGTGGAG GTTGTGGTGA GCCAAGATCA CGCCATTACA CTCCAGCCTG 4001 GGCAAAGAGA GTGAAACTGT CTCAAAAAAC AAAACAAATG ACCCCCCTGC 4051 CAAAAAAAAA AAAAAAAAAA AAGAAAAGAA AAAAAGAAAA GCCTAGCTCA 4101 GCTCACACTG TCAGGAATAA GTAAGCTAGC TGGAATCATC TCTTTCTTAA Exon C3 4151 AACCCTGCCT TGATAGTGGA TTTTTACATA CTTTTTTTTT AATTCTAGAA 4201 ATGGAGTCAT CAGTTTATCA ACCAACAAGC AGCTCCAGCA CCCAGCACTT 4251 CTACCTGAAT TTCACCATCA CCAACCTACC ATATTCCCAG GACAAAGCCC 4301 AGCCAGGCAC CACCAATTAC CAGAGGAACA AAAGGAATAT TGAGGATGCG 4351 GTGAGAAGGG GGTGGTATGT CCACTCTGTT GCCATGCAGA AACTGACTTA 4401 TGCATACTGG GTAGCCACAG GGTGACTTTT TATAACAATC CACAAAGACA 4451 GGTTCTTATT CCCATTTAAT ACACAAGCAC AGAGAGGTTC AGTAGCTGAC 4501 CCAAGGTCAC ACAGCTAAGT CATACCCTAG AAGAGCATGT CCTTTGATAT 4551 ACATACCTGG GCAAGTGGTT GTCATGACAA GAAGCAAAAT AGACGGAGAA 4601 GTGTGCTCAG TGGCTGAAAA TTCTCTGATG CTACTGGGGC CAGGATTCTG Exon C4 4651 ACCTAAGAAA CATCGCCCTG TCTTTCAGCT CAACCAACTC TTCCGAAACA 4701 GCAGCATCAA GAGTTATTTT TCTGACTGTC AAGTTTCAAC ATTCAGGTAA 4751 GTTCTAACTC AGGACCTAAT GACTCTAGGA ACTTCTGCTG TCCTTTAAAT 4801 AGAAGTGTCC CCAAGCCATA GCTTTGATGG AAGAGAGCCC TAGAAATAGA 4851 GAGCTGTTAA CTAAAAACTA GCTTTTTCCT AAAGCTGGAG CCCAACTGGC 4901 TTCAACACTC AAGAGAGCTG GTGTAAATCT CAGCAGACAT AAAGGTACCT 4951 GGTGCTGAGG CCATGGAGTC TAGAGTGTAG AATCTACTAC ATTAAGACAT 5001 CAGCTACTGA AATCAGGACC CATGGAAGAC GGGGGAAGGA GGGGACTAAA 5051 ACCAGATTAC TTAGAATCTA GCAGCCTAAC TGTGCTTTTC AATGAGAGGT 5101 ATCATTTCCA ATGGTGGGGG GTACCAATGA TTTTTTTTTT TTGACAACTG 5151 CCTTGAGAAC AGGCTTTCCT CACTAAACAA ATTCTGAATC AGAACAAATA 5201 AAGATAAGCC CTGAGAATAG GGCTTTTTCA AGGAGCTGCC AAACAGATCA 5251 AATAGTGACT ATGTTCTGCA GATTGATGTC TGGAGAACTC TACAGCTATT 5301 TTGACTGCTA GGCAGCTGGT TTTCACAGAT ATCATGATTC TGAGGCTGCC 5351 AGTTTTCAAA GTTACCGAGG ATCTTGCTGG ATGCAGTGGC TTGCGACTGT 5401 AATCCCAGCC CTTTGGGAGG CCAAGGTGGG TAGATCGCTT GAGCTCAGGA 5451 GTTTGAGACC AGCCTGGGCA ATATGGTGAA AACCCATCTC TACAAAAAAT 5501 ACAAAAATCA GCTGAGCATA GTGGCATGTG CTGTAGTCCC AGTTACTTAG 5551 GAGGCTGAGG TGGGAGGATG GCTTGAGCCC AGGAGGCAGA GGTTGCAGTG 5601 AGCTGACATT GTGCCATGCA CTCTAGCCTG GGCAACAGAG CCAAAGCCTG 5651 TCTCAAAAAA AAAAAAACAA ATAATAATAA TAATAAAATA CTGAGGATCT 5701 TGAAAGAGCA CTGTGGAAAT AATGCAAGTT AAAATGCCAC AAAGCTTGCT 5751 CTTTTTACTG AGATTTAACA CTTTCCTTAA CTAAACACCC CTCGAATTTT 5801 TGCAAGCCTT TGGTTCACTT CTAGACTTCT GGPAAAATTG ATTTGGACTA 5851 TTTTGGCCAA TGTTCTCATT GATTTTATGG GTATTCAGAA GTTGTTACCC 5901 CAACATTCCA GAAATGTTCT CCCTGTGGCT ATTACTTTAT TTATTTATTT 5951 ATTTATTTAT TTATTTATTT ATTTGAGACG GAGTCTCCCT CTGTTGCCCA 6001 GGCTGGAGTG CAGTGGCGCA ATCTCAGCTC ACTGCAACCT CCGCTTCCCA 6051 GGTTCAAGCG ATTCTCCTGC CTCAGCCTCC CAAGTAGCTG GGATTATGGA 6101 TGTGCACCAC CACACCGGCT AATTTTTGTG TTTTTAGTAG AGATGGGGTT 6151 TCACTGTGTT GGCCAGGCTG GTCTCGAACT CCTGATCTCA AGTGATCCAC 6201 CCGCCTTGGC CTCCCAAAGT GCTGGGATAA CAGGCATGAG CCACTGTGCC 6251 TGACCTCCCT GTGGCTATTT TTAAATGAAT TAAGTGGAAT AAAATTAGAA 6301 ATTCAGTTCT TCTCCCACGC TAGCTGCATT TTAAGCATTT AATAACAACA 6351 TGAAGCTACT AATGGCTGCA TTGTGTAGTG CAGATGTAGA ATTTTTTTTT 6401 TGTTTTTTGT TTTGTTTTTG AGATGGAGTC TCGCTCTGTC ACCAGGCTAG 6451 AGTGCAGTGG CGTGATCTCG TCTCACTGCA ATCTCTACTC CCCGATTCAA 6501 GTGATTCTCC TGCCTCAGCC TCCCAAGTAG CTGGGATTAC AGGCACGTGC 6551 CACCACACCC AGCTAATATT TGTATGGATG GTCTCAATCT CCTGACCTCG 6601 TGATTTGTAT GGATGGTCTC GATCTGACCT CATGATCCGC CTGCCTGGGC 6651 CTCCCAAAGT GCTGGGATTA CAGGCGTGAG CCACTGTGCC CGGCCGACAT 6701 AGAATGTTTA CATCATTGCA GAAAGTTTCT GCAGGAAGAG CCTAGAAGGA 6751 GAAAGCCTAG AATCATGATA AAATTGCAGA TATCTTTGCT TATCCCTGTC Exon C5 6801 CCCTTCCAGG TCTGTCCCCA ACAGGCACCA CACCGGGGTG GACTCCCTGT 6851 GTAACTTCTC GCCACTGGCT CGGAGAGTAG ACAGAGTTGC CATCTATGAG 6901 GAATTTCTGC GGATGACCCG GAATGGTACC CAGCTGCAGA ACTTCACCCT 6951 GGACAGGAGC AGTGTCCTTG TGGATGGTAA AGCTCCCTGG GTCATTGGGA 7001 CTGAGGTGGA AGCTCCCACT TCCTCACCTG GGTCCTTCCC TGGGAATCTG 7051 AAGGCTTGGG GTTGATTCGT CATCGAGCTT TCTCAGACTG GGAGAAAGTG 7101 GCTTAGTTCT CCTAAGCTTT ACCCATCATT GAAGGAAAGA AAAGGACGCC 7151 CGAGGGATAT GGGAGGCATT TGCCCTCTTC TGGCCAGCTC TGTGACCTCA 7201 GGCTAGTCAC ATCTCCTTTC TGGACTTCTT ATCTCTCTGT ACTTAGCAAG 7251 CCACTTGGTT TTTGGTTCCC ATCTTGCCTG CCCTAGATGG TATTGCTCCT 7301 CCACCCCCAG GCAGCTGCAG TGTTAAACAA TTACCCTGAT TAGTTATTGT 7351 TGTTGTGTTG TTTGTTTGTT TTTGAGACAG GGTCTCACTC TGTCACCTAG 7401 GCTGGAGTGC AGTGACATGA TCTCAGCTCA CTGCAACCTC AACCCCTGGA 7451 CTCAAGCAAT CCACCCACTT CAGCCTCCCA AGTAACTGGG ACTACAGCCA 7501 TGCGCCACCA CACCCGGATA ATTTTTGTAT TTTTTCTAGA GATGGGGTTT 7551 TGCAACATTG CCCAGGCTGG TCTTGAACTC CTGAGCTCAA GCATGCCACC 7601 TGCTTCAGCC TCCCAAAGTG CTGGGATTAC AGGCAGGCAG GCACCACTGC 7651 AGCTGGTTCT GGTTTTTTGT GTTTGTTTTT TTCTTTTAGA GGCAGGGTCT 7701 CGCTCTGTTA ACCAGAATGG AGTACAGTGG TGCAATCATA GCTCACTGCA 7751 GTCTTGAACT CCTGGGCTCA AGCGATCCTC CCACCTCAGC CTCCTGAGTA 7801 CCTGGAACTA CAGGCACGTG TCACCACGCC TTGCTAATTT CTAAATTTTT 7851 TGTAGAGACA GGGTCTCACT ATGTTGCCCA GACTGGTCTC TAATTCCTGG 7901 CCACAAGTGA TCCTCCTGCC TCAGCAGGTC AATGAGGGCT TCCAGTTTCA 7951 AGTTGTATGT GATTCATCCT CAACAAATGT GGTAGGATGG ACCTATTTTC 8001 CAACTCCAGA GATGGCTTCA AGGTGGCTCA ACTTTGCATA TCCAATTTTA 8051 CCCATTCAAA GAATAGTTAT ATACATTGTA CCATGTATCA GGAATATAAC 8101 AGAGAGTAAC TGTTTGCTCT TTCACCACTA TATTCCAAGA ACCCCATATT 8151 CTGCCTGGCA CATAATAAAC ACTCAAGTCA TATTTGCAGA AGGAATAACT 8201 AGATTTCATA CAAGGTTCTT TTCAAGTCAA ATGCGAATAA CGTTTTAGAC 8251 GGGACCTTCC AATGCCTGTG TGCACTGTCC TTGATTCCGA ATTATTGTTG 8301 TGCAAGAGAG CACTGTTGAT CCTTCAGAAT CAACAAGCCT TTCACATGCC 8351 TGTCACAGGT TTTTCTTTTT CTTGTTTTAC CAATTTTGTT TGTTGTTTGT 8401 TTGTTGTTAT TGTTTTGTTT TGTTTTTGTT TTTTATTTGT TTTTATTTTT 8451 TCTTTTTTTT TGAGACAGAG TCTCGCTCTG TCACCCAGGC TGGAGTGCAG 8501 TGGCACGATC TCCGCCCACT GCAAGCTCCG CCTCCTGGGT TCATGCCATT 8551 TTCCTGCCTC AGCCTCCTGA GTAGCTGGGA CTACAGGCGC CTGCCACCAT 8601 GTCTGGCTAA TTTTTTTTGT ATTTTTAGTA GAAACAGGGT TTCACCATGT 8651 TGACCAGGAT GGTCTCGATC TCCTGACCTC GTGATCTGCC CACCTGGGCC 8701 TCCCAAAGTG CTGGGATTAC AGGCGTGAGC CACCACACCC AGCCCCAATT 8751 TTTTTTTTAA TTAAAATTGT TGTCAGCTCA CAAGCTTTCT AAAAACAGGC 8801 CATGGACCCA GCATCGCTGT AGTTTGCCAA ACCCTTGCCT TGAATCAGTA 8851 CCATCCAATA GAACTTTCTG CAGTGATAGA AAATGTTTCT ATCTGTGCTA 8901 TTCAGCACAA AGCCATGTGT GATTACTAAG CTTGAAGTGT GGTTAATGTA 8951 ACTGAGATAC CGAAGTTTTA ATTTTATTTA ATTTTAATTT AAAAAGCCAC 9001 TTGTGGCTGC TCCATATTGC ACACTACTTT TTAAAATTAT TATTTGTATA 9051 TATTTAAGGG GCACAAGTAC AATTTTGTTG CATGGATTTA TAGCCCAGTG 9101 GGGAAGTCTG GGCTTTTAGG GTATCTATTA CCTGAATAAT GTACATTGTA 9151 CCCATTGAGT AATTTCTCAT CATCCACTCT CCTCCACTCC CCAACCCTTC 9201 CAAGTTTCCA CTGTCTATTA TTCCACTCTC TATGTCCATG CCTATGCATT 9251 ATTTAGCATT GACATGTCTA TGCATTATTT AGTCAAATAC ATGTGCTATT 9301 TGACTTCCTG TATCTGAGTT GTTTGACTTA AGATAATGAC CTTCACTTGC 9351 ATCCATGTTG CTGCAAAAGA CATGATTTCA TTCTTTTTTA TGCCTGGGTG 9401 GTATTGCATT GTGTGTGTGT GTGTGTGTGT GTGTGTAGAG AGAGAGAGAG 9451 ATCACATTTT CTTTATACAG TCCTCCATTG ATGGGCACTT AGGTTGATTC 9501 CATATCTTTG CTATTGTGAA TAGTTTTGTG ATAAACACAC AGGTTCAGGT 9551 GTCTTTTTGA CAAAATTATT TATTTTCCTT TGTGTAGATA CCCAGTCGTG 9601 GGATTCCTGG ATCAAATGGT AGTTTCATTT TTAGTTATTT GAGAAATCTC 9651 CACGTTTTTC ATAGAGATTA TACTAAATTA CATTCCCACC AACAGTGTGT 9701 AACGGTTCAC TTTTCTTGCA TCCTTTTTAA CATCTGTTAT TTTTGTCTTT 9751 TTAGTAACAG CCATTCTGAC TGGCGTAAGG TGGTATCTCA TCATGGTTTT 9801 AATCTGTATT TCTCTGATTA TTAGTAATGT CGAGCATTTT TTCATATGCT 9851 TGTTAGCCAT TGGTATGTCT TCTACATCTT TAAGAAGCTG GCTATGGGCT 9901 GGGCGCAGTG GCTCACACCT GTAATCCCAG CACTTTGGGA GGCCGAGGCA 9951 GGCGGATCAC GAGGTCAGGA GTTAAAAACC AGCCTGGCCA ACATGGTAAA 10001 ACCCTGCCTC TACTAAAAAT ACAAAAAATT ACCCAGGCAT GGTGGTGCGC 10051 CTGTAATCCC AGCTACTCAG GAAGCTGAGG CAGGAGAATC ACTTGAACCC 10101 AGGAGGCGGA GGTTGCAGTG AGACGAGATC ACATCATTGC ACTCCAGCCT 10151 GGGTGACAGA GTGAGACTCT ATCTTGAGAA AAAAAAAAAG TTGGCTATAA 10201 CAGGGTTGTA GAAGTAGAGG AACCAGTAAC CCTTCTCGCC ATGCCTGATG 10251 ATGGCTTTAC ATCCCTGTCT TCATGGAGTT TATGCTGTCG TGAGGAATAA 10301 CAAGAACAGG CAGTTGTCAA TTATAAATTA TTTGATGTGA ACCTATTCAT 10351 ACATGGGTGT GGTCATCAGG GAAGGCTTCC TGGAGGAAAT GACATTGAAG 10401 GTGAATTCTA AAAGATGACG ATAAACCACC AAGTGAAGGA GAGCTTAAAT 10451 GTGTTTTTAG GCAGAAGAAA AACCTTTTGG GTGAAAATTT TAAAACTTAG 10501 AGAGGTCCCA TCAGTTTCCA ACTGCGATGA TCCATTCTCT CCACCACTGC 10551 CCTTGGGCCC AGCCCAATTT AGGTCCACCA TGCCCAGAGG CATGAATTTA 10601 ACTTATGACA CTCTTGTGGT GGAATAATGG CTTTGGGCTT ATGTAGCCAT 10651 GTGTCATTTT TTTAGAGATA CAAATTGAAA TATTTGGGGT GAGATGTCAT 10701 GGTGTCTACT GGCCTCTAAA ACTTCAGTGA AAACATTTAC TTTCACTGAA 10751 ATGTCAATAA ATCATAAATT GGATGTATAT GTTTTAGTTG GAGGAAATAT 10801 AAACCACTAA ATCTAGGTGA TGCATATTTA TTATACTCTT CTCTCTGCTT 10851 TTTTGTACGC TTGTAAAATT GTATTTAAAA GAATAAGACA CACTTGGCCG 10901 GGCGCGGTGG CTCACGCCTG TAATCCCAGC ACTTTGGGAG ACCGAGGTGG 10951 GTGGATCATG AGGTCAGGAG TTCAAGACCA GCCTGGCCAA CATGGTAAAA 11001 CTCCATCACT ACATACAAAA ATTAGCCAGG CATTTTGGCG GGCACCTGTA 11051 ATCTCAGCTA CTTGGGAGGC TGAAGCAGGA GAATTGCTTG AACCCGGGAA 11101 GCAGAGGTTG CAGTGAGCCA AGATCACGCC ACTGCACTCT AGCCTGGGCA 11151 ACAGAGCAAG ACTCCATCTC CAGAPAAAAA AAAAAAAAAA GACACACTCA Exon C6 11201 CATGCACCCT CCATTTCTTT CATTTCTAGG GTATTCTCCC AACAGAAATG 11251 AGCCCTTAAC TGGGAATTCT GGTAAGTCTC AAAGAAGCCC CAGCCCAGGG 11301 TAGGGAGGGG GTAGCCTGAT GGTGCTTTGC CTTGTCCAAG AGCACCAGGC 11351 ACACAGAGTC TTGGATGAGG ATCAAAATTG CCAACCCATG GCAAAGACTA 11401 TTGAGGCATA GTAAAGGGAT AGCAGGGATC CTGGCTTTCT GGGGGCCCAG 11451 TTTTTGGGGG CATCAGAGGC ATGAGGTGTT GAGCCACTAA GCTCTCTTCC 11501 CCAGGGGCTG TGCCCATCCT CAGGCCACAT AGGGTCCAAG AAGGAGCCCT Exon C7 11551 GGGACGTGGC AGGAGGTGGC TCACCCCAGC CCTTGTCTCC CCAGACCTTC 11601 CCTTCTGGGC TGTCATCCTC ATCGGCTTGG CAGGACTCCT GGGAGTCATC 11651 ACATGCCTGA TCTGCGGTGT CCTGGTGAGC AAGGAAGGGT TGCTTGTCTT 11701 CTTAACAATT GGGTTGTAAG AGTTCTTAAT ATATTATAAA ACCATACTAT 11751 ACTATACACA AGTCCTTTGC TGGATATATG TTTTGCAAAT ATTTTCTCCC 11801 AGTTCACGGA GTGGCTTTCC TATTTTCTTT TTATAATTTT ATTTTTAATT 11851 AATTGACAAA TAATGAATGC ATATATTTAG GGGATACAAT GTGATGCTTT 11901 GGTATATGTA CAATTATGGA ATGACTCAAT CAAGCTAATT AATATGTCCC 11951 TCACCTCTCA TACTTATTAT TTCTTTGTGG TGTGAACATT GGCAACCTAT 12001 ACTCTTAGCA ATTTTGAAAT CTACATTATT ATTAACTATA GTTACTATGT 12051 TATGCAGATC TCAAAAACTT CACAACCTAT ATGCTGATTA CAAGATATTG 12101 AGAGAAAAAG TGATTGCAAA GAGTGTAAAT AAAATAATGT AAGAGGGAAA 12151 AATGTAACAA AATTAGTCGT TAGGGAAATG TACACGGAAG TCACAATGAG 12201 AGGCCACTTT TCACAAGAAT GGATAAAATT GAAAAGATTG ACTATAACAA 12251 GTGTTGGTGA AAATGTGACA GAACTGGAAC TCTCATAAAG TGAAAGTGGA 12301 AAATAGCTTG GCCATTTCTT TGAAAATTAC ACACACCTAC CGTAAGACCT 12351 ACCATCCCAC TACTAGTAAT TTATCTAAGA GAAATAAAAA CATATGTCTA 12401 TATGAAGACT TGTACACAAG TAAATGTTCA TAACAGCTTT GTTTGTAATA 12451 GCCAAACTCT GAAAACAAGC CCCTAATGTC CATTAACAAA TATATCCTGA 12501 CAATGGAATA TTATTCAGCA ACAAAAAGGA ATTATTAATA CATTAATAAA 12551 TTATACAGCA ACATGTATAA ATTGCAAAAT AGTTATGCCT AGTGAAAGAA 12601 TCCAGATGAA GAAAAGAGTA CATGCCATAT GATTCCCTTA ATAGACAAAT 12651 TCTAGAAAAT ACAAACTAAT CTGTAAGGAC AGGAATCAGA TCAGCGGTTG 12701 CCTGGGAATG AAAATGTGTT TGCAGTGGCA GGGAAAAAGG AATTGTAAAA 12751 GAGCAGGAAG AAAGTTTTTT TGTTGTTTTT TTTTTGTTTT TTCTTGAGAC 12801 AGAGTCTTAG TCTATCGCCC AAGCTGGAGT GCAATGGCAC GATCTCAGCT 12851 CATTGCAACC TCTGCCTCTC GGGTTCAAGC GTTTTTCCTG CCCCAGCCTC 12901 CCAAGTAGCT GGGATTACAC ATGCGCACCA CCACACTCAG CTAATTTTTG 12951 TATTTTTAGT AGAGACGGGG TTTTACCATG TTGGCCAGGC TGGTCTCGAA 13001 CTCCTGACCT CAGGTGATCC ACCCGCCTTG GCCTCCCAAA GTGCTGGGAT 13051 TACAGGAGTG AGCCACCATG CCTGGCCAGG ACGAAAGTTT TGGGGATGAT 13101 GGATGGATGT TCCTTATGTT GATTGTGGTG ACGATTCAAT AAGTTATGAT 13151 CAGAACTTAT CAAAACATTC ACTTTAAATG TGTGCAGTTT ATTTTATGTC 13201 AGTTATGCCT CAGTTAAGCT GGACAGATGT AGAGGAGGAA GGGAGGGAGA 13251 GAGGGGGCTG AGATCAGGAC CAAAAGCCAG AGAGAAAGAG ACTGAGAATG 13301 AGATGAGAGA GAAATGGTAT TTAGACAGAA GACAGGCGAT AGATGATTGA 13351 TAGTTGACAG ATGATTGGTG GATANNNNNN NNNNNNNNNN NNNNNNNNNN 13401 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 13451 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 13501 AGGAGGTTTA AACAAAACGC AATTATGTTG AAATGACAAT GATTGTGGAT 13551 ATAAAGGTAG ATAGAAATAG ATATTTGTGA AGATAATGGT TAGATAAAAA 13601 TGATAGGTAA CAGATATTGA TAGATCTTGA TAAGTAGATG ATAAATACAT 13651 GATTGATGGA TGACAGGTGA TTGATAGATG ATTTGATGGA TTATAAATAG 13701 GAGATGATTG AGAGGTGAGA GATAATTGAT GGTTATTTGA TTGGTAGATA 13751 ATTGATTGAC AGGTTGATAA ATATTGATAG CTAGATGATA GATAAATAGA 13801 TCATTGGTAG ATATGTGATA TATTGATAAA GAAATTCAGA GGCAAAAGGA 13851 GAGAGAAATG AAGGGGATAT CGGAGGGGGA AAAATTTTTT TAAACCGAGA 13901 GTGAAACAAG GAGACAGAAG AAAAGAAAGT GGTGAAAAGA GGAAAAGAAC 13951 TGAGGGAGAA ATTAAATGAA ACAATGAAGG GAGACAGAGG AAGCATAAGG Exon C8 14001 CCTCTGGCTT TGGCCATATT CTCACCCCTG TGGTCTCCTC TCCCTGGACG 14051 GCTGACCAGT CCATTCTCAC GCCTCCTCCT CACCCTCATA GGTGACCACC 14101 CGCCGGCGGA AGAAGGAAGG AGAATACAAC GTCCAGCAAC AGTGCCCAGG 14151 CTACTACCAG TCACACCTAG ACCTGGAGGA TCTGCAATGA CTGGAACTTG 14201 CCGGTGCCTG GGGTGCCTTT CCCCCAGCCA GGGTCCAAAG AAGCTTGGCT 14251 GGGGCAGAAA TAAACCATAT TGGTCGG

[0056] 4 TABLE 4 Human cDNA of CA125 (SEQ ID NO:4) 1 AAGCGTTGCA CAATTCCCCC AACCTCCATA CATACGGCAG CTCTTCTAGA 51 CACAGGTTTT CCCAGGTCAA ATGCGGGGAC CCCAGCCATA TCTCCCACCC 101 TGAGAAATTT TGGAGTTTCA GGGAGCTCAG AAGCTCTGCA GAGGCCACCC 151 TCTCTGAGGG GATTCTTCTT AGACCTCCAT CCAGAGGCAA ATGTTGACCT 201 GTCCATGCTG AAACCCTCAG GCCTTCCTGG GTCATCTTCT CCCACCCGCT 251 CCTTGATGAC AGGGAGCAGG AGCACTAAAG CCACACCAGA AATGGATTCA 301 GGACTGACAG GAGCCACCTT GTCACCTAAG ACATCTACAG GTGCAATCGT 351 GGTGACAGAA CATACTCTGC CCTTTACTTC CCCAGATAAG ACCTTGGCCA 401 GTCCTACATC TTCGGTTGTG GGAAGAACCA CCCAGTCTTT GGGGGTGATG 451 TCCTCTGCTC TCCCTGAGTC AACCTCTAGA GGAATGACAC ACTCCGAGCA 501 AAGAACCAGC CCATCGCTGA GTCCCCAGGT CAATGGAACT CCCTCTAGGA 551 ACTACCCTGC TACAAGCATG GTTTCAGGAT TGAGTTCCCC AAGGACCAGG 601 ACCAGTTCCA CAGAAGGAAA TTTTACCAAA GAAGCATCTA CATACACACT 651 CACTGTAGAG ACCACAAGTG GCCCAGTCAC TGAGAAGTAC ACAGTCCCCA 701 CTGAGACCTC AACAACTGAA GGTGACAGCA CAGAGACCCC CTGGGACACA 751 AGATATATTC CTGTAAAAAT CACATCTCCA ATGAAAACAT TTGCAGATTC 801 AACTGCATCC AAGGAAAATG CCCCAGTGTC TATGACTCCA GCTGAGACCA 851 CAGTTACTGA CTCACATACT CCAGGAAGGA CAAACCCATC ATTTGGGACA 901 CTTTATTCTT CCTTCCTTGA CCTATCACCT AAAGGGACCC CAAATTCCAG 951 AGGTGAAACA AGCCTGGAAC TGATTCTATC AACCACTGGA TATCCCTTCT 1001 CCTCTCCTGA ACCTGGCTCT GCAGGACACA GCAGAATAAG TACCAGTGCG 1051 CCTTTGTCAT CATCTGCTTC AGTTCTCGAT AATAAAATAT CAGAGACCAG 1101 CATATTCTCA GGCCAGAGTC TCACCTCCCC TCTGTCTCCT GGGGTGCCCG 1151 AGGCCAGAGC CAGCACAATG CCCAACTCAG CTATCCCTTT TTCCATGACA 1201 CTAAGCAATG CAGAAACAAG TGCCGAAAGG GTCAGAAGCA CAATTTCCTC 1251 TCTGGGGACT CCATCAATAT CCACAAAGCA GACAGCAGAG ACTATCCTTA 1301 CCTTCCATGC CTTCGCTGAG ACCATGGATA TACCCAGCAC CCACATAGCC 1351 AAGACTTTGG CTTCAGAATG GTTGGGAAGT CCAGGTACCC TTGGTGGCAC 1401 CAGCACTTCA GCGCTGACAA CCACATCTCC ATCTACCACT TTAGTCTCAG 1451 AGGAGACCAA CACCCATCAC TCCACGAGTG GAAAGGAAAC AGAAGGAACT 1501 TTGAATACAT CTATGACTCC ACTTGAGACC TCTGCTCCTG GAGAAGAGTC 1551 CGAAATGACT GCCACCTTGG TCCCCACTCT AGGTTTTACA ACTCTTGACA 1601 GCAAGATCAG AAGTCCATCT CAGGTCTCTT CATCCCACCC AACAAGAGAG 1651 CTCAGAACCA CAGGCAGCAC CTCTGGGAGG CAGAGTTCCA GCACAGCTGC 1701 CCACGGGAGC TCTGACATCC TGAGGGCAAC CACTTCCAGC ACCTCAAAAG 1751 CATCATCATG GACCAGTGAA AGCACAGCTC AGCAATTTAG TGAACCCCAG 1801 CACACACAGT GGGTGGAGAC AAGTCCTAGC ATGAAAACAG AGAGACCCCC 1851 AGCATCAACC AGTGTGGCAG CCCCTATCAC CACTTCTGTT CCCTCAGTGG 1901 TCTCTGGCTT CACCACCCTG AAGACCAGCT CCACAAAAGG GATTTGGCTT 1951 GAAGAAACAT CTGCAGACAC ACTCATCGGA GAATCCACAG CTGGCCCAAC 2001 CACCCATCAG TTTGCTGTTC CCACTGGGAT TTCAATGACA GGAGGCAGCA 2051 GCACCAGGGG AAGCCAGGGC ACAACCCACC TACTCACCAG AGCCACAGCA 2101 TCATCTGAGA CATCCGCAGA TTTGACTCTG GCCACGAACG GTGTCCCAGT 2151 CTCCGTGTCT CCAGCAGTGA GCAAGACGGC TGCTGGCTCA AGTCCTCCAG 2201 GAGGGACAAA GCCATCATAT ACAATGGTTT CTTCTGTCAT CCCTGAGACA 2251 TCATCTCTAC AGTCCTCAGC TTTCAGGGAA GGAACCAGCC TGGGACTGAC 2301 TCCATTAAAC ACTAGACATC CCTTCTCTTC CCCTGAACCA GACTCTGCAG 2351 GACACACCAA GATAAGCACC AGCATTCCTC TGTTGTCATC TGCTTCAGTT 2401 CTTGAGGATA AAGTGTCAGC GACCAGCACA TTCTCACACC ACAAAGCCAC 2451 CTCATCTATT ACCACAGGGA CTCCTGAAAT CTCAACAAAG ACAAAGCCCA 2501 GCTCAGCCGT TCTTTCCTCC ATGACCCTAA GCAATGCAGC AACAAGTCCT 2551 GAAAGAGTCA GAAATGCAAC TTCCCCTCTG ACTCATCCAT CTCCATCAGG 2601 GGAAGAGACA GCAGGGAGTG TCCTCACTCT CAGCACCTCT GCTGAGACTA 2651 CAGACTCACC TAACATCCAC CCAACTGGGA CACTGACTTC AGAATCGTCA 2701 GAGAGTCCTA GCACTCTCAG CCTCCCAAGT GTCTCTGGAG TCAAAACCAC 2751 ATTTTCTTCA TCTACTCCTT CCACTCATCT ATTTACTAGT GGAGAAGAAA 2801 CAGAGGAAAC TTCGAATCCA TCTGTGTCTC AACCTGAGAC TTCTGTTTCC 2851 AGAGTAAGGA CCACCTTGGC CAGCACCTCT GTCCCTACCC CAGTATTCCC 2901 CACCATGGAC ACCTGGCCTA CACGTTCAGC TCAGTTCTCT TCATCCCACC 2951 TAGTGAGTGA GCTCAGAGCT ACGAGCAGTA CCTCAGTTAC AAACTCAACT 3001 GGTTCAGCTC TTCCTAAAAT ATCTCACCTC ACTGGGACGG CAACAATGTC 3051 ACAGACCAAT AGAGACACGT TTAATGACTC TGCTGCACCC CAAAGCACAA 3101 CTTGGCCAGA GACTAGTCCC AGATTCAAGA CAGGGTTACC TTCAGCAACA 3151 ACCACTGTTT CAACCTCTGC CACTTCTCTC TCTGCTACTG TAATGGTCTC 3201 TAAATTCACT TCTCCAGCAA CTAGTTCCAT GGAAGCAACT TCTATCAGGG 3251 AACCATCAAC AACCATCCTC ACAACAGAGA CCACGAATGG CCCAGGCTCT 3301 ATGGCTGTGG CTTCTACCAA CATCCCAATT GGAAAGGGCT ACATTACTGA 3351 AGGAAGATTG GACACAAGCC ATCTGCCCAT TGGAACCACA GCTTCCTCTG 3401 AGACATCTAT GGATTTTACC ATGGCCAAAG AAAGTGTCTC AATGTCAGTA 3451 TCTCCATCTC AGTCCATGGA TGCTGCTGGC TCAAGCACTC CAGGAAGGAC 3501 AAGCCAATTC GTTGACACAT TTTCTGATGA TGTCTATCAT TTAACATCCA 3551 GAGAAATTAC AATACCTAGA GATGGAACAA GCTCAGCTCT GACTCCACAA 3601 ATGACTGCAA CTCACCCTCC ATCTCCTGAT CCTGGCTCTG CTAGAAGCAC 3651 CTGGCTTGGC ATCTTGTCCT CATCTCCTTC TTCTCCTACT CCCAAAGTCA 3701 CAATGAGCTC CACATTTTCA ACTCAGAGAG TCACCACAAG CATGATAATG 3751 GACACAGTTG AAACTAGTCG GTGGAACATG CCCAACTTAC CTTCCACGAC 3801 TTCCCTGACA CCAAGTAATA TTCCAACAAG TGGTGCCATA GGAAAAAGCA 3851 CCCTGGTTCC CTTGGACACT CCATCTCCAG CCACATCATT GGAGGCATCA 3901 GAAGGGGGAC TTCCAACCCT CAGCACCTAC CCTGAATCAA CAAACACACC 3951 CAGCATCCAC CTCGGAGCAC ACGCTAGTTC AGAAAGTCCA AGCACCATCA 4001 AACTTACCAT GGCTTCAGTA GTAAAACCTG GCTCTTACAC ACCTCTCACC 4051 TTCCCCTCAA TAGAGACCCA CATTCATGTA TCAACAGCCA GAATGGCTTA 4101 CTCTTCTGGG TCTTCACCTG AGATGACAGC TCCTGGAGAG ACTAACACTG 4151 GTAGTACCTG GGACCCCACC ACCTACATCA CCACTACGGA TCCTAAGGAT 4201 ACAAGTTCAG CTCAGGTCTC TACACCCCAC TCAGTGAGGA CACTCAGAAC 4251 CACAGAAAAC CATCCAAAGA CAGAGTCCGC CACCCCAGCT GCTTACTCTG 4301 GAAGTCCTAA AATCTCAAGT TCACCCAATC TCACCAGTCC GGCCACAAAA 4351 GCATGGACCA TCACAGACAC AACTGAACAC TCCACTCAAT TACATTACAC 4401 AAAATTGGCA GAAAAATCAT CTGGATTTGA GACACAGTCA GCTCCAGGAC 4451 CTGTCTCTGT AGTAATCCCT ACCTCCCCTA CCATTGGAAG CAGCACATTG 4501 GAACTAACTT CTGATGTCCC AGGGGAACCC CTGGTCCTTG CTCCCAGTGA 4551 GCAGACCACA ATCACTCTCC CCATGGCAAC ATGGCTGAGT ACCAGTTTGA 4601 CAGAGGAAAT GGCTTCAACA GACCTTGATA TTTCAAGTCC AAGTTCACCC 4651 ATGAGTACAT TTGCTATTTT TCCACCTATG TCCACACCTT CTCATGAACT 4701 TTCAAAGTCA GAGGCAGATA CCAGTGCCAT TAGAAATACA GATTCAACAA 4751 CGTTGGATCA GCACCTAGGA ATCAGGAGTT TGGGCAGAAC TGGGGACTTA 4801 ACAACTGTTC CTATCACCCC ACTGACAACC ACGTGGACCA GTGTGATTGA 4851 ACACTCAACA CAAGCACAGG ACACCCTTTC TGCAACGATG AGTCCTACTC 4901 ACGTGACACA GTCACTCAAA GATCAAACAT CTATACCAGC CTCAGCATCC 4951 CCTTCCCATC TTACTGAAGT CTACCCTGAG CTCGGGACAC AAGGGAGAAG 5001 CTCCTCTGAG GCAACCACTT TTTGGAAACC ATCTACAGAC ACACTGTCCA 5051 GAGAGATTGA GACTGGCCCA ACAAACATTC AATCCACTCC ACCCATGGAC 5101 AACACAACAA CAGGGAGCAG TAGTAGTGGA GTCACCCTGG GCATAGCCCA 5151 CCTTCCCATA GGAACATCCT CCCCAGCTGA GACATCCACA AACATGGCAC 5201 TGGAAAGAAG AAGTTCTACA GCCACTGTCT CTATGGCTGG GACAATGGGA 5251 CTCCTTGTTA CTAGTGCTCC AGGAAGAAGC ATCAGCCAGT CATTAGGAAG 5301 AGTTTCCTCT GTCCTTTCTG AGTCAACTAC TGAAGGAGTC ACAGATTCTA 5351 GTAAGGGAAG CAGCCCAAGG CTGAACACAC AGGGAAATAC AGCTCTCTCC 5401 TCCTCTCTTG AACCCAGCTA TGCTGAAGGA AGCCAGATGA GCACAAGCAT 5451 CCCTCTAACC TCATCTCCTA CAACTCCTGA TGTGGAATTC ATAGGGGGCA 5501 GCACATTTTG GACCAAGGAG GTCACCACAG TTATGACCTC AGACATCTCC 5551 AAGTCTTCAG CAAGGACAGA GTCCAGCTCA GCTACCCTTA TGTCCACAGC 5601 TTTGGGAAGC ACTGAAAATA CAGGAAAAGA AAAACTCAGA ACTGCCTCTA 5651 TGGATCTTCC ATCTCCAACT CCATCAATGG AGGTGACACC ATGGATTTCT 5701 CTCACTCTCA GTAATGCCCC CAATACCACA GATTCACTTG ACCTCAGCCA 5751 TGGGGTGCAC ACCAGCTCTG CAGGGACTTT GGCCACTGAC AGGTCATTGA 5801 ATACTGGTGT CACTAGAGCC TCCAGATTGG AAAACGGCTC TGATACCTCT 5851 TCTAAGTCCC TGTCTATGGG AAACAGCACT CACACTTCCA TGACTGACAC 5901 AGAGAAGAGT GAAGTGTCTT CTTCAATCCA TCCCCGACCT GAGACCTCAG 5951 CTCCTGGAGC AGAGACCACT TTGACTTCCA CTCCTGGAAA CAGGGCCATA 6001 AGCTTAACAT TGCCTTTTTC ATCCATTCCA GTGGAAGAAG TCATTTCTAC 6051 AGGCATAACC TCAGGACCAG ACATCAACTC AGCACCCATG ACACATTCTC 6101 CCATCACCCC ACCAACAATT GTATGGACCA GTACAGGCAC AATTGAACAG 6151 TCCACTCAAC CACTACATGC AGTTTCTTCA GAAAAAGTTT CTGTGCAGAC 6201 ACAGTCAACT CCATATGTCA ACTCTGTGGC AGTGTCTGCT TCCCCTACCC 6251 ATGAGAATTC AGTCTCTTCT GGAAGCAGCA CATCCTCTCC ATATTCCTCA 6301 GCCTCACTTG AATCCTTGGA TTCCACAATC AGTAGGAGGA ATGCAATCAC 6351 TTCCTGGCTA TGGGACCTCA CTACATCTCT CCCCACTACA ACTTGGCCAA 6401 GTACTAGTTT ATCTGAGGCA CTGTCCTCAG GCCATTCTGG GGTTTCAAAC 6451 CCAAGTTCAA CTACGACTGA ATTTCCACTC TTTTCAGCTG CATCCACATC 6501 TGCTGCTAAG CAAAGAAATC CAGAAACAGA GACCCATGGT CCCCAGAATA 6551 CAGCCGCGAG TACTTTGAAC ACTGATGCAT CCTCGGTCAC AGGTCTTTCT 6601 GAGACTCCTG TGGGGGCAAG TATCAGCTCT GAAGTCCCTC TTCCAATGGC 6651 CATAACTTCT AGATCAGATG TTTCTGGCCT TACATCTGAG AGTACTGCTA 6701 ACCCGAGTTT AGGCACAGCC TCTTCAGCAG GGACCAAATT AACTAGGACA 6751 ATATCCCTGC CCACTTCAGA GTCTTTGGTT TCCTTTAGAA TGAACAAGGA 6801 TCCATGGACA GTGTCAATCC CTTTGGGGTC CCATCCAACT ACTAATACAG 6851 AAACAAGCAT CCCAGTAAAC AGCGCAGGTC CACCTGGCTT GTCCACAGTA 6901 GCATCAGATG TAATTGACAC ACCTTCAGAT GGGGCTGAGA GTATTCCCAC 6951 TGTCTCCTTT TCCCCCTCCC CTGATACTGA AGTGACAACT ATCTCACATT 7001 TCCCAGAAAA GACAACTCAT TCATTTAGAA CCATTTCATC TCTCACTCAT 7051 GAGTTGACTT CAAGAGTGAC ACCTATTCCT GGGGATTGGA TGAGTTCAGC 7101 TATGTCTACA AAGCCCACAG GAGCCAGTCC CTCCATTACA CTGGGAGAGA 7151 GAAGGACAAT CACCTCTGCT GCTCCAACCA CTTCCCCCAT AGTTCTCACT 7201 GCTAGTTTCA CAGAGACCAG CACAGTTTCA CTGGATAATG AAACTACAGT 7251 AAAAACCTCA GATATCCTTG ACGCACGGAA AACAAATGAG CTCCCCTCAG 7301 ATAGCAGTTC TTCTTCTGAT CTGATCAACA CCTCCATAGC TTCTTCAACT 7351 ATGGATGTCA CTAAAACAGC CTCCATCAGT CCCACTAGCA TCTCAGGAAT 7401 GACAGCAAGT TCCTCCCCAT CTCTCTTCTC TTCAGATAGA CCCCAGGTTC 7451 CCACATCTAC AACAGAGACA AATACAGCCA CCTCTCCATC TGTTTCCAGT 7501 AACACCTATT CTCTTGATGG GGGCTCCAAT GTGGGTGGCA CTCCATCCAC 7551 TTTACCACCC TTTACAATCA CCCACCCTGT CGAGACAAGC TCGGCCCTAT 7601 TAGCCTGGTC TAGACCAGTA AGAACTTTCA GCACCATGGT CAGCACTGAC 7651 ACTGCCTCCG GAGAAAATCC TACCTCTAGC AATTCTGTGG TGACTTCTGT 7701 TCCAGCACCA GGTACATGGG CCAGTGTAGG CAGTACTACT GACTTACCTG 7751 CCATGGGCTT TCTCAAGACA AGTCCTGCAG GAGAGGCACA CTCACTTCTA 7801 GCATCAACTA TTGAACCAGC CACTGCCTTC ACTCCCCATC TCTCAGCAGC 7851 AGTGGTCACT GGATCCAGTG CTACATCAGA AGCCAGTCTT CTCACTACGA 7901 GTGAAAGCAA AGCCATTCAT TCTTCACCAC AGACCCCAAC TACACCCACC 7951 TCTGGAGCAA ACTGGGAAAC TTCAGCTACT CCTGAGAGCC TTTTGGTAGT 8001 CACTGAGACT TCAGACACAA CACTTACCTC AAAGATTTTG GTCACAGATA 8051 CCATCTTGTT TTCAACTGTG TCCACGCCAC CTTCTAAATT TCCAAGTACG 8101 GGGACTCTGT CTGGAGCTTC CTTCCCTACT TTACTCCCGG ACACTCCAGC 8151 CATCCCTCTC ACTGCCACTG AGCCAACAAG TTCATTAGCT ACATCCTTTG 8201 ATTCCACCCC ACTGGTGACT ATAGCTTCGG ATAGTCTTGG CACAGTCCCA 8251 GAGACTACCC TGACCATGTC AGAGACCTCA AATGGTGATG CACTGGTTCT 8301 TAAGACAGTA AGTAACCCAG ATAGGAGCAT CCCTGGAATC ACTATCCAAG 8351 GAGTAACAGA AAGTCCACTC CATCCTTCTT CCACTTCCCC CTCTAAGATT 8401 GTTGCTCCAC GGAATACAAC CTATGAAGGT TCGATCACAG TGGCACTTTC 8451 TACTTTGCCT GCGGGAACTA CTGGTTCCCT TGTATTCAGT CAGAGTTCTG 8501 AAAACTCAGA GACAACGGCT TTGGTAGACT CATCAGCTGG GCTTGAGAGG 8551 GCATCTGTGA TGCCACTAAC CACAGGAAGC CAGGGTATGG CTAGCTCTGG 8601 AGGAATCAGA AGTGGGTCCA CTCACTCAAC TGGAACCAAA ACATTTTCTT 8651 CTCTCCCTCT GACCATGAAC CCAGGTGAGG TTACAGCCAT GTCTGAAATC 8701 ACCACGAACA GACTGACAGC TACTCAATCA ACAGCACCCA AAGGGATACC 8751 TGTGAAGCCC ACCAGTGCTG AGTCAGGCCT CCTAACACCT GTCTCTGCCT 8801 CCTCAAGCCC ATCAAAGGCC TTTGCCTCAC TGACTACAGC TCCCCCATCA 8851 ACTTGGGGGA TCCCACAGTC TACCTTGACA TTTGAGTTTT CTGAGGTCCC 8901 AAGTTTGGAT ACTAAGTCCG CTTCTTTACC AACTCCTGGA CAGTCCCTGA 8951 ACACCATTCC AGACTCAGAT GCAAGCACAG CATCTTCCTC ACTGTCCAAG 9001 TCTCCAGAAA AAAACCCAAG GGCAAGGATG ATGACTTCCA CAAAGGCCAT 9051 AAGTGCAAGC TCATTTCAAT CAACAGGTTT TACTGAAACC CCTGAGGGAT 9101 CTGCCTCCCC TTCTATGGCA GGGCATGAAC CCAGAGTCCC CACTTCAGGA 9151 ACAGGGGACC CTAGATATGC CTCAGAGAGC ATGTCTTATC CAGACCCAAG 9201 CAAGGCATCA TCAGCTATGA CATCGACCTC TCTTGCATCA AAACTCACAA 9251 CTCTCTTCAG CACAGGTCAA GCAGCAAGGT CTGGTTCTAG TTCCTCTCCC 9301 ATAAGCCTAT CCACTGAGAA AGAAACAAGC TTCCTTTCCC CCACTGCATC 9351 CACCTCCAGA AAGACTTCAC TATTTCTTGG GCCTTCCATG GCAAGGCAGC 9401 CCAACATATT GGTGCATCTT CAGACTTCAG CTCTGACACT TTCTCCAACA 9451 TCCACTCTAA ATATGTCCCA GGAGGAGCCT CCTGAGTTAA CCTCAAGCCA 9501 GACCATTGCA GAAGAAGAGG GAACAACAGC TGAAACACAG ACGTTAACCT 9551 TCACACCATC TGAGACCCCA ACATCCTTGT TACCTGTCTC TTCTCCCACA 9601 GAACCCACAG CCAGAAGAAA GAGTTCTCCA GAAACATGGG CAAGCTCTAT 9651 TTCAGTTCCT GCCAAGACCT CCTTGGTTGA AACAACTGAT GGAACGCTAG 9701 TGACCACCAT AAAGATGTCA AGCCAGGCAG CACAAGGAAA TTCCACGTGG 9751 CCTGCCCCAG CAGAGGAGAC GGGGACCAGT CCAGCAGGCA CATCCCCAGG 9801 AAGCCCAGAA GTGTCTACCA CTCTCAAAAT CATGAGCTCC AAGGAACCCA 9851 GCATCAGCCC AGAGATCAGG TCCACTGTGC GAAATTCTCC TTGGAAGACT 9901 CCAGAAACAA CTGTTCCCAT GGAGACCACA GTGGAACCAG TCACCCTTCA 9951 GTCCACAGCC CTAGGAAGTG GCAGCACCAG CATCTCTCAC CTGCCCACAG 10001 GAACCACATC ACCAACCAAG TCACCAACAG AAAATATGTT GGCTACAGAA 10051 AGGGTCTCCC TCTCCCCATC CCCACCTGAG GCTTGGACCA ACCTTTATTC 10101 TGGAACTCCA GGAGGGACCA GGCAGTCACT GGCCACAATG TCCTCTGTCT 10151 CCCTAGAGTC ACCAACTGCT AGAAGCATCA CAGGGACTGG TCAGCAAAGC 10201 AGTCCAGAAC TGGTTTCAAA GACAACTGGA ATGGAATTCT CTATGTGGCA 10251 TGGCTCTACT GGAGGGACCA CAGGGGACAC ACATGTCTCT CTGAGCACAT 10301 CTTCCAATAT CCTTGAAGAC CCTGTAACCA GCCCAAACTC TGTGAGCTCA 10351 TTGACAGATA AATCCAAACA TAAAACCGAG ACATGGGTAA GCACCACAGC 10401 CATTCCCTCC ACTGTCCTGA ATAATAAGAT AATGGCAGCT GAACAACAGA 10451 CAAGTCGATC TGTGGATGAG GCTTATTCAT CAACTAGTTC TTGGTCAGAT 10501 CAGACATCTG GGAGTGACAT CACCCTTGGT GCATCTCCTG ATGTCACAAA 10551 CACATTATAC ATCACCTCCA CAGCACAAAC CACCTCACTA GTGTCTCTGC 10601 CCTCTGGAGA CCAAGGCATT ACAAGCCTCA CCAATCCCTC AGGAGGAAAA 10651 ACAAGCTCTG CGTCATCTGT CACATCTCCT TCAATAGGGC TTGAGACTCT 10701 GAGGGCCAAT GTAAGTGCAG TGAAAAGTGA CATTGCCCCT ACTGCTGGGC 10751 ATCTATCTCA GACTTCATCT CCTGCGGAAG TGAGCATCCT GGACGTAACC 10801 ACAGCTCCTA CTCCAGGTAT CTCCACCACC ATCACCACCA TGGGAACCAA 10851 CTCAATCTCA ACTACCACAC CCAACCCAGA AGTGGGTATG AGTACCATGG 10901 ACAGCACCCC GGCCACAGAG AGGCGCACAA CTTCTACAGA ACACCCTTCC 10951 ACCTGGTCTT CCACAGCTGC ATCAGATTCC TGGACTGTCA CAGACATGAC 11001 TTCAAACTTG AAAGTTGCAA GATCTCCTGG AACAATTTCC ACAATGCATA 11051 CAACTTCATT CTTAGCCTCA AGCACTGAAT TAGACTCCAT GTCTACTCCC 11101 CATGGCCGTA TAACTGTCAT TGGAACCAGC CTGGTCACTC CATCCTCTGA 11151 TGCTTCAGCT GTAAAGACAG AGACCAGTAC AAGTGAAAGA ACATTGAGTC 11201 CTTCAGACAC AACTGCATCT ACTCCCATCT CAACTTTTTC TCGTGTCCAG 11251 AGGATGAGCA TCTCAGTTCC TGACATTTTA AGTACAAGTT GGACTCCCAG 11301 TAGTACAGAA GCAGAAGATG TGCCTGTTTC AATGGTTTCT ACAGATCATG 11351 CTAGTACAAA GACTGACCCA AATACGCCCC TGTCCACTTT TCTGTTTGAT 11401 TCTCTGTCCA CTCTTGACTG GGACACTGGG AGATCTCTGT CATCAGCCAC 11451 AGCCACTACC TCAGCTCCTC AGGGGGCCAC AACTCCCCAG GAACTCACTT 11501 TGGAAACCAT GATCAGCCCA GCTACCTCAC AGTTGCCCTT CTCTATAGGG 11551 CACATTACAA GTGCAGTCAC ACCAGCTGCA ATGGCAAGGA GCTCTGGAGT 11601 TACTTTTTCA AGACCAGATC CCACAAGCAA AAAGGCAGAG CAGACTTCCA 11651 CTCAGCTTCC CACCACCACT TCTGCACATC CAGGGCAGGT GCCCAGATCA 11701 GCAGCAACAA CTCTGGATGT GATCCCACAC ACAGCAAAAA CTCCAGATGC 11751 AACTTTTCAG AGACAAGGGC AGACAGCTCT TACAACAGAG GCAAGAGCTA 11801 CATCTGACTC CTGGAATGAG AAAGAAAAAT CAACCCCAAG TGCACCTTGG 11851 ATCACTGAGA TGATGAATTC TGTCTCAGAA GATACCATCA AGGAGGTTAC 11901 CAGCTCCTCC AGTGTATTAA AGGACCCTGA ATACGCTGGA CATAAACTTG 11951 GAATCTGGGA CGACTTCATC CCCAAGTTTG GAAAAGCAGC CCATATGAGA 12001 GAGTTGCCCC TTCTGAGTCC ACCACAGGAC AAAGAGGCAA TTCACCCTTC 12051 TACAAACACA GTAGAGACCA CAGGCTGGGT CACAAGTTCC GAACATGCTT 12101 CTCATTCCAC TATCCCAGCC CACTCAGCGT CATCCAAACT CACATCTCCA 12151 GTGGTTACAA CCTCCACCAG GGAACAAGCA ATAGTTTCTA TGTCAACAAC 12201 CACATGGCCA GAGTCTACAA GGGCTAGAAC AGAGCCTAAT TCCTTCTTGA 12251 CTATTGAACT GAGGGACGTC AGCCCTTACA TGGACACCAG CTCAACCACA 12301 CAAACAAGTA TTATCTCTTC CCCAGGTTCC ACTGCGATCA CCAAGGGGCC 12351 TAGAACAGAA ATTACCTCCT CTAAGAGAAT ATCCAGCTCA TTCCTTGCCC 12401 AGTCTATGAG GTCGTCAGAC AGCCCCTCAG AAGCCATCAC CAGGCTGTCT 12451 AACTTTCCTG CCATGACAGA ATCTGGAGGA ATGATCCTTG CTATGCAAAC 12501 AAGTCCACCT GGCGCTACAT CACTAAGTGC ACCTACTTTG GATACATCAG 12551 CCACAGCCTC CTGGACAGGG ACTCCACTGG CTACGACTCA GAGATTTACA 12601 TACTCAGAGA AGACCACTCT CTTTAGCAAA GGTCCTGAGG ATACATCACA 12651 GCCAAGCCCT CCCTCTGTGG AAGAAACCAG CTCTTCCTCT TCCCTGGTAC 12701 CTATCCATGC TACAACCTCG CCTTCCAATA TTTTGTTGAC ATCACAAGGG 12751 CACAGTCCCT CCTCTACTCC ACCTGTGACC TCAGTTTTCT TGTCTGAGAC 12801 CTCTGGCCTG GGGAAGACCA CAGACATGTC GAGGATAAGC TTGGAACCTG 12851 GCACAAGTTT ACCTCCCAAT TTGAGCAGTA CAGCAGGTGA GGCGTTATCC 12901 ACTTATGAAG CCTCCAGAGA TACAAAGGCA ATTCATCATT CTGCAGACAC 12951 AGCAGTGACG AATATGGAGG CAACCAGTTC TGAATATTCT CCTATCCCAG 13001 GCCATACAAA GCCATCCAAA GCCACATCTC CATTGGTTAC CTCCCACATC 13051 ATGGGGGACA TCACTTCTTC CACATCAGTA TTTGGCTCCT CCGAGACCAC 13101 AGAGATTGAG ACAGTGTCCT CTGTGAACCA GGGACTTCAG GAGAGAAGCA 13151 CATCCCAGGT GGCCAGCTCT GCTACAGAGA CAAGCACTGT CATTACCCAT 13201 GTGTCTAGTG GTGATGCTAC TACTCATGTC ACCAAGACAC AAGCCACTTT 13251 CTCTAGCGGA ACATCCATCT CAAGCCCTCA TCAGTTTATA ACTTCTACCA 13301 ACACATTTAC AGATGTGAGC ACCAACCCCT CCACCTCTCT GATAATGACA 13351 GAATCTTCAG GAGTGACCAT CACCACCCAA ACAGGTCCTA CTGGAGCTGC 13401 AACACAGGGT CCATATCTCT TGGACACATC AACCATGCCT TACTTGACAG 13451 AGACTCCATT AGCTGTGACT CCAGATTTTA TGCAATCAGA GAAGACCACT 13501 CTCATAAGCA AAGGTCCCAA GGATGTGACC TGGACAAGCC CTCCCTCTGT 13551 GGCAGAAACC AGCTATCCCT CTTCCCTGAC ACCTTTCTTG GTCACAACCA 13601 TACCTCCTGC CACTTCCACG TTACAAGGGC AACATACATC CTCTCCTGTT 13651 TCTGCGACTT CAGTTCTTAC CTCTGGACTG GTGAAGACCA CAGATATGTT 13701 GAACACAAGC ATGGAACCTG TGACCAATTC ACCTCAAAAT TTGAACAATC 13751 CATCAAATGA GATACTGGCC ACTTTGGCAG CCACCACAGA TATAGAGACT 13801 ATTCATCCTT CCATAAACAA AGCAGTGACC AATATGGGGA CTGCCAGTTC 13851 AGCACATGTA CTGCATTCCA CTCTCCCAGT CAGCTCAGAA CCATCTACAG 13901 CCACATCTCC AATGGTTCCT GCCTCCAGCA TGGGGGACGC TCTTGCTTCT 13951 ATATCAATAC CTGGTTCTGA GACCACAGAC ATTGAGGGAG AGCCAACATC 14001 CTCCCTGACT GCTGGACGAA AAGAGAACAG CACCCTCCAG GAGATGAACT 14051 CAACTACAGA GTCAAACATC ATCCTCTCCA ATGTGTCTGT GGGGGCTATT 14101 ACTGAAGCCA CAAAAATGGA AGTCCCCTCT TTTGATGCAA CATTCATACC 14151 AACTCCTGCT CAGTCAACAA AGTTCCCAGA TATTTTCTCA GTAGCCAGCA 14201 GTAGACTTTC AAACTCTCCT CCCATGACAA TATCTACCCA CATGACCACC 14251 ACCCAGACAG GGTCTTCTGG AGCTACATCA AAGATTCCAC TTGCCTTAGA 14301 CACATCAACC TTGGAAACCT CAGCAGGGAC TCCATCAGTG GTGACTGAGG 14351 GGTTTGCCCA CTCAAAAATA ACCACTGCAA TGAACAATGA TGTCAAGGAC 14401 GTGTCACAGA CAAACCCTCC CTTTCAGGAT GAAGCCAGCT CTCCCTCTTC 14451 TCAAGCACCT GTCCTTGTCA CAACCTTACC TTCTTCTGTT GCTTTCACAC 14501 CGCAATGGCA CAGTACCTCC TCTCCTGTTT CTATGTCCTC AGTTCTTACT 14551 TCTTCACTGG TAAAGACCGC AGGCAAGGTG GATACAAGCT TAGAAACAGT 14601 GACCAGTTCA CCTCAAAGTA TGAGCAACAC TTTGGATGAC ATATCGGTCA 14651 CTTCAGCAGC CACCACAGAT ATAGAGACAA CGCATCCTTC CATAAACACA 14701 GTAGTTACCA ATGTGGGGAC CACCGGTTCA GCATTTGAAT CACATTCTAC 14751 TGTCTCAGCT TACCCAGAGC CATCTAAAGT CACATCTCCA AATGTTACCA 14801 CCTCCACCAT GGAAGACACC ACAATTTCCC GATCAATACC TAAATCCTCT 14851 AAGACTACAA GAACTGAGAC TGAGACAACT TCCTCCCTGA CTCCTAAACT 14901 GAGGGAGACC AGCATCTCCC AGGAGATCAC CTCGTCCACA GAGACAAGCA 14951 CTGTTCCTTA CAAAGAGCTC ACTGGTGCCA CTACCGAGGT ATCCAGGACA 15001 GATGTCACTT CCTCTAGCAG TACATCCTTC CCTGGCCCTG ATCAGTCCAC 15051 AGTGTCACTA GACATCTCCA CAGAAACCAA CACCAGGCTG TCTACCTCCC 15101 CAATAATGAC AGAATCTGCA GAAATAACCA TCACCACCCA AACAGGTCCT 15151 CATGGGGCTA CATCACAGGA TACTTTTACC ATGGACCCAT CAAATACAAC 15201 CCCCCAGGCA GGGATCCACT CAGCTATGAC TCATGGATTT TCACAATTGG 15251 ATGTGACCAC TCTTATGAGC AGAATTCCAC AGGATGTATC ATGGACAAGT 15301 CCTCCCTCTG TGGATAAAAC CAGCTCCCCC TCTTCCTTTC TGTCCTCACC 15351 TGCAATGACC ACACCTTCCC TGATTTCTTC TACCTTACCA GAGGATAAGC 15401 TCTCCTCTCC TATGACTTCA CTTCTCACCT CTGGCCTAGT GAAGATTACA 15451 GACATATTAC GTACACGCTT GGAACCTGTG ACCAGCTCAC TTCCAAATTT 15501 CAGCAGCACC TCAGATAAGA TACTGGCCAC TTCTAAAGAC AGTAAAGACA 15551 CAAAGGAAAT TTTTCCTTCT ATAAACACAG AAGAGACCAA TGTGAAAGCC 15601 AACAACTCTG GACATGAATC CCATTCCCCT GCACTGGCTG ACTCAGAGAC 15651 ACCCAAAGCC ACAACTCAAA TGGTTATCAC CACCACTGTG GGAGATCCAG 15701 CTCCTTCCAC ATCAATGCCA GTGCATGGTT CCTCTGAGAC TACAAACATT 15751 AAGAGAGAGC CAACATATTT CTTGACTCCT AGACTGAGAG AGACCAGTAC 15801 CTCTCAGGAG TCCAGCTTTC CCACGGACAC AAGTTTTCTA CTTTCCAAAG 15851 TCCCCACTGG TACTATTACT GAGGTCTCCA GTACAGGGGT CAACTCTTCT 15901 AGCAAAATTT CCACCCCAGA CCATGATAAG TCCACAGTGC CACCTGACAC 15951 CTTCACAGGA GAGATCCCCA GGGTCTTCAC CTCCTCTATT AAGACAAAAT 16001 CTGCAGAAAT GACGATCACC ACCCAAGCAA GTCCTCCTGA GTCTGCATCG 16051 CACAGTACCC TTCCCTTGGA CACATCAACC ACACTTTCCC AGGGAGGGAC 16101 TCATTCAACT GTGACTCAGG GATTCCCATA CTCAGAGGTG ACCACTCTCA 16151 TGGGCATGGG TCCTGGGAAT GTGTCATGGA TGACAACTCC CCCTGTGGAA 16201 GAAACCAGCT CTGTGTCTTC CCTGATGTCT TCACCTGCCA TGACATCCCC 16251 TTCTCCTGTT TCCTCCACAT CACCACAGAG CATCCCCTCC TCTCCTCTTC 16301 CTGTGACTGC ACTTCCTACT TCTGTTCTGG TGACAACCAC AGATGTGTTG 16351 GGCACAACAA GCCCAGAGTC TGTAACCAGT TCACCTCCAA ATTTGAGCAG 16401 CATCACTCAT GAGAGACCGG CCACTTACAA AGACACTGCA CACACAGAAG 16451 CCGCCATGCA TCATTCCACA AACACCGCAG TGACCAATGT AGGGACTTCC 16501 GGGTCTGGAC ATAAATCACA ATCCTCTGTC CTAGCTGACT CAGAGACATC 16551 GAAAGCCACA CCTCTGATGA GTACCACCTC CACCCTGGGG GACACAAGTG 16601 TTTCCACATC AACTCCTAAT ATCTCTCAGA CTAACCAAAT TCAAACAGAG 16651 CCAACAGCAT CCCTGAGCCC TAGACTGAGG GAGAGCAGCA CGTCTGAGAA 16701 GACCAGCTCA ACAACAGAGA CAAATACTGC CTTTTCTTAT GTGCCCACAG 16751 GTGCTATTAC TCAGGCCTCC AGAACAGAAA TCTCCTCTAG CAGAACATCC 16801 ATCTCAGACC TTGATCGGCC CACAATAGCA CCCGACATCT CCACAGGAAT 16851 GATCACCAGG CTCTTCACCT CCCCCATCAT GACAAAATCT GCAGAAATGA 16901 CCGTCACCAC TCAAACAACT ACTCCTGGGG CTACATCACA GGGTATCCTT 16951 CCTTGGGACA CATCAACCAC ACTTTTCCAG GGAGGGACTC ATTCAACCGT 17001 GTCTCAGGGA TTCCCACACT CAGAGATAAC CACTCTTCGG AGCAGAACCC 17051 CTGGAGATGT GTCATGGATG ACAACTCCCC CTGTGGAAGA AACCAGCTCT 17101 GGGTTTTCCC TGATGTCACC TTCCATGACA TCCCCTTCTC CTGTTTCCTC 17151 CACATCACCA GAGAGCATCC CCTCCTCTCC TCTCCCTGTG ACTGCACTTC 17201 TTACTTCTGT TCTGGTGACA ACCACCAATG TATTGGGCAC AACAAGCCCA 17251 GAGACCGTAA CGAGTTCACC TCCAAATTTA AGCAGCCCCA CACAGGAGAG 17301 ACTGACCACT TACAAAGACA CTGCGCACAC AGAAGCCATG CATGCTTCCA 17351 TGCATACAAA CACTGCAGTG GCCAACGTCG GGACCTCCAT TTCTGGACAT 17401 GAATCACAAT CTTCTGTCCC AGCTGATTCA CACACATCCA AAGCCACATC 17451 TCCAATGGGT ATCACCTTCG CCATGGGGGA TACAAGTGTT TCTACATCAA 17501 CTCCTGCCTT CTTTGAGACT AGAATTCAGA CTGAATCAAC ATCCTCTTTG 17551 ATTCCTGGAT TAAGGGACAC CAGGACGTCT GAGGAGATCA ACACTGTGAC 11761 AGAGACCAGC ACTGTCCTTT CAGAAGTGCC CACTACTACT ACTACTGAGG 17651 TCTCCAGGAC AGAAGTTATC ACTTCCAGCA GAACAACCAT CTCAGGGCCT 17701 GATCATTCCA AAATGTCACC CTACATCTCC ACAGAAACCA TCACCAGGCT 17751 CTCCACTTTT CCTTTTGTAA CAGGATCCAC AGAAATGGCC ATCACCAACC 17801 AAACAGGTCC TATAGGGACT ATCTCACAGG CTACCCTTAC CCTGGACACA 17851 TCAAGCACAG CTTCCTGGGA AGGGACTCAC TCACCTGTGA CTCAGAGATT 17901 TCCACACTCA GAGGAGACCA CTACTATGAG CAGAAGTACT AAGGGCGTGT 17951 CATGGCAAAG CCCTCCCTCT GTGGAAGAAA CCAGTTCTCC TTCTTCCCCA 18001 GTGCCTTTAC CTGCAATAAC CTCACATTCA TCTCTTTATT CCGCAGTATC 18051 AGGAAGTAGC CCCACTTCTG CTCTCCCTGT GACTTCCCTT CTCACCTCTG 18101 GCAGGAGGAA GACCATAGAC ATGTTGGACA CACACTCAGA ACTTGTGACC 18151 AGCTCCTTAC CAAGTGCAAG TAGCTTCTCA GGTGAGATAC TCACTTCTGA 18201 AGCCTCCACA AATACAGAGA CAATTCACTT TTCAGAGAAC ACAGCAGAAA 18251 CCAATATGGG GACCACCAAT TCTATGCATA AACTACATTC CTCTGTCTCA 18301 ATCCACTCCC AGCCATCCGG ACACACACCT CCAAAGGTTA CTGGATCTAT 18351 GATGGAGGAC GCTATTGTTT CCACATCAAC ACCTGGTTCT CCTGAGACTA 18401 AAAATGTTGA CAGAGACTCA ACATCCCCTC TGACTCCTGA ACTGAAAGAG 18451 GACAGCACCG CCCTGGTGAT GAACTCAACT ACAGAGTCAA ACACTGTTTT 18501 CTCCAGTGTG TCCCTGGATG CTGCTACTGA GGTCTCCAGG GCAGAAGTCA 18551 CCTACTATGA TCCTACATTC ATGCCAGCTT CTGCTCAGTC AACAAAGTCC 18601 CCAGACATTT CACCTGAAGC CAGCAGCAGT CATTCTAACT CTCCTCCCTT 18651 GACAATATCT ACACACAAGA CCATCGCCAC ACAAACAGGT CCTTCTGGGG 18701 TGACATCTCT TGGCCAACTG ACCCTGGACA CATCAACCAT AGCCACCTCA 18751 GCAGGAACTC CATCAGCCAG AACTCAGGAT TTTGTAGATT CAGAAACAAC 18801 CAGTGTCATG AACAATGATC TCAATGATGT GTTGAAGACA AGCCCTTTCT 18851 CTGCAGAAGA AGCCAACTCT CTCTCTTCTC AGGCACCTCT CCTTGTGACA 18901 ACCTCACCTT CTCCTGTAAC TTCCACATTG CAAGAGCACA GTACCTCCTC 18951 TCTTGTTTCT GTGACCTCAG TACCCACCCC TACACTGGCG AAGATCACAG 19001 ACATGGACAC AAACTTAGAA CCTGTGACTC GTTCACCTCA AAATTTAAGG 19051 AACACCTTGG CCACTTCAGA AGCCACCACA GATACACACA CAATGCATCC 19101 TTCTATAAAC ACAGCAATGG CCAATGTGGG GACCACCAGT TCACCAAATG 19151 AATTCTATTT TACTGTCTCA CCTGACTCAG ACCCATATAA AGCCACATCC 19201 GCAGTAGTTA TCACTTCCAC CTCGGGGGAC TCAATAGTTT CCACATCAAT 19251 GCCTAGATCC TCTGCGATGA AAAAGATTGA GTCTGAGACA ACTTTCTCCC 19301 TGATATTTAG ACTGAGGGAG ACTAGCACCT CCCAGAAAAT TGGCTCATCC 19351 TCAGACACAA GCACGGTCTT TGACAAAGCA TTCACTGCTG CTACTACTGA 19401 GGTCTCCAGA ACAGAACTCA CCTCCTCTAG CAGAACATCC ATCCAAGGCA 19451 CTGAAAAGCC CACAATGTCA CCGGACACCT CCACAAGATC TGTCACCATG 19501 CTTTCTACTT TTGCTGGCCT GACAAAATCC GAAGAAAGGA CCATTGCCAC 19551 CCAAACAGGT CCTCATAGGG CGACATCACA GGGTACCCTT ACCTGGGACA 19601 CATCAATCAC AACCTCACAG GCAGGGACCC ACTCAGCTAT GACTCATGGA 19651 TTTTCACAAT TAGATTTGTC CACTCTTACG AGTAGAGTTC CTGAGTACAT 19701 ATCAGGGACA AGCCCACCCT CTGTGGAAAA AACCAGCTCT TCCTCTTCCC 19751 TTCTGTCTTT ACCAGCAATA ACCTCACCGT CCCCTGTACC TACTACATTA 19801 CCAGAAAGTA GGCCGTCTTC TCCTGTTCAT CTGACTTCAC TCCCCACCTC 19851 TGGCCTAGTG AAGACCACAG ATATGCTGGC ATCTGTGGCC AGTTTACCTC 19901 CAAACTTGGG CAGCACCTCA CATAAGATAC CGACTACTTC AGAAGACATT 19951 AAAGATACAG AGAAAATGTA TCCTTCCACA AACATAGCAG TAACCAATGT 20001 GGGGACCACC ACTTCTGAAA AGGAATCTTA TTCGTCTGTC CCAGCCTACT 20051 CAGAACCACC CAAAGTCACC TCTCCAATGG TTACCTCTTT CAACATAAGG 20101 GACACCATTG TTTCCACATC CATGCCTGGC TCCTCTGAGA TTACAAGGAT 20151 TGAGATGGAG TCAACATTCT CCGTGGCTCA TGGGCTGAAG GGAACCAGCA 20201 CCTCCCAGGA CCCCATCGTA TCCACAGAGA AAAGTGCTGT CCTTCACAAG 20251 TTGACCACTG GTGCTACTGA GACCTCTAGG ACAGAAGTTG CCTCTTCTAG 20301 AAGATCATCC ATTCCAGGCC CTGATCATTC CACAGAGTCA CCAGACATCT 20351 CCACTGAAGT GATCCCCAGC CTGCCTATCT CCCTTGGCAT TACAGAATCT 20401 TCAAATATGA CCATCATCAC TCGAACAGGT CCTCCTCTTG GCTCTACATC 20451 ACAGGGCACA TTTACCTTGG ACACACCAAC TACATCCTCC AGGGCAGGAA 20501 CACACTCGAT GGCGACTCAG GAATTTCCAC ACTCAGAAAT GACCACTGTC 20551 ATGAACAAGG ACCCTGAGAT TCTATCATGG ACAATCCCTC CTTCTATAGA 20601 GAAAACCAGC TTCTCCTCTT CCCTGATGCC TTCACCAGCC ATGACTTCAC 20651 CTCCTGTTTC CTCAACATTA CCAAAGACCA TTCACACCAC TCCTTCTCCT 20701 ATGACCTCAC TGCTCACCCC TAGCCTAGTG ATGACCACAG ACACATTGGG 20751 CACAAGCCCA GAACCTACAA CCAGTTCACC TCCAAATTTG AGCAGTACCT 20801 CACATGTGAT ACTGACAACA GATGAAGACA CCACAGCTAT AGAAGCCATG 20851 CATCCTTCCA CAAGCACAGC AGCGACTAAT GTGGAAACCA CCTGTTCTGG 20901 ACATGGGTCA CAATCCTCTG TCCTAACTGA CTCAGAAAAA ACCAAGGCCA 20951 CAGCTCCAAT GGATACCACC TCCACCATGG GGCATACAAC TGTTTCCACA 21001 TCAATGTCTG TTTCCTCTGA GACTACAAAA ATTAAGAGAG AGTCAACATA 21051 TTCCTTGACT CCTGGACTGA GAGAGACCAG CATTTCCCAA AATGCCAGCT 21101 TTTCCACTGA CACAAGTATT GTTCTTTCAG AAGTCCCCAC TGGTACTACT 21151 GCTGAGGTCT CCAGGACAGA AGTCACCTCC TCTGGTAGAA CATCCATCCC 21201 TGGCCCTTCT CAGTCCACAG TTTTGCCAGA AATATCCACA AGAACAATGA 21251 CAAGGCTCTT TGCCTCGCCC ACCATGACAG AATCAGCAGA AATGACCATC 21301 CCCACTCAAA CAGGTCCTTC TGGGTCTACC TCACAGGATA CCCTTACCTT 21351 GGACACATCC ACCACAAAGT CCCAGGCAAA GACTCATTCA ACTTTGACTC 21401 AGAGATTTCC ACACTCAGAG ATGACCACTC TCATGAGCAG AGGTCCTGGA 21451 GATATGTCAT GGCAAAGCTC TCCCTCTCTG GAAAATCCCA GCTCTCTCCC 21501 TTCCCTGCTG TCTTTACCTG CCACAACCTC ACCTCCTCCC ATTTCCTCCA 21551 CATTACCAGT GACTATCTCC TCCTCTCCTC TTCCTGTGAC TTCACTTCTC 21601 ACCTCTAGCC CGGTAACGAC CACAGACATG TTACACACAA GCCCAGAACT 21651 TGTAACCAGT TCACCTCCAA AGCTGAGCCA CACTTCAGAT GAGAGACTGA 21701 CCACTGGCAA GGACACCACA AATACAGAAG CTGTGCATCC TTCCACAAAC 21751 ACAGCAGCGT CCAATGTGGA GATTCCCAGC TTTGGACATG AATCCCCTTC 21801 CTCTGCCTTA GCTGACTCAG AGACATCCAA AGCCACATCA CCAATGTTTA 21851 TTACCTCCAC CCAGGAGGAT ACAACTGTTG CCATATCAAC CCCTCACTTC 21901 TTGGAGACTA GCAGAATTCA GAAAGAGTCA ATTTCCTCCC TGAGCCCTAA 21951 ATTGAGGGAG ACAGGCAGTT CTGTGGAGAC AAGCTCAGCC ATAGAGACAA 22001 GTGCTGTCCT TTCTGAAGTG TCCATTGGTG CTACTACTGA GATCTCCAGG 22051 ACAGAAGTCA CCTCCTCTAG CAGAACATCC ATCTCTGGTT CTGCTGAGTC 22101 CACAATGTTG CCAGAAATAT CCACCACAAG AAAAATCATT AAGTTCCCTA 22151 CTTCCCCCAT CCTGGCAGAA TCATCAGAAA TGACCATCAA GACCCAAACA 22201 AGTCCTCCTG GGTCTACATC AGAGAGTACC TTTACATTAG ACACATCAAC 22251 CACTCCCTCC TTGGTAATAA CCCATTCGAC TATGACTCAG AGATTGCCAC 22301 ACTCAGAGAT AACCACTCTT GTGAGTAGAG GTGCTGGGGA TGTGCCACGG 22351 CCCAGCTCTC TCCCTGTGGA AGAAACAAGC CCTCCATCTT CCCAGCTGTC 22401 TTTATCTGCC ATGATCTCAC CTTCTCCTGT TTCTTCCACA TTACCAGCAA 22451 GTAGCCACTC CTCTTCTGCT TCTGTGACTT CACCTCTCAC ACCAGGCCAA 22501 GTGAAGACTA CTGAGGTGTT GGACGCAAGT GCAGAACCTG AAACCAGTTC 22551 ACCTCCAAGT TTGAGCAGCA CCTCAGTTGA AATACTGGCC ACCTCTGAAG 22601 TCACCACAGA TACGGAGAAA ATTCATCCTT TCCCAAACAC GGCAGTAACC 22651 AAAGTTGGAA CTTCCAGTTC TGGACATGAA TCCCCTTCCT CTGTCCTACC 22701 TGACTCAGAG ACAACCAAAG CCACATCGGC AATGGGTACC ATCTCCATTA 22751 TGGGGGATAC AAGTGTTTCT ACATTAACTC CTGCCTTATC TAACACTAGG 22801 AAAATTCAGT CAGAGCCAGC TTCCTCACTG ACCACCAGAT TGAGGGAGAC 22851 CAGCACCTCT GAAGAGACCA GCTTAGCCAC AGAAGCAAAC ACTGTTCTTT 22901 CTAAAGTGTC CACTGGTGCT ACTACTGAGG TCTCCAGGAC AGAAGCCATC 22951 TCCTTTAGCA GAACATCCAT GTCAGGCCCT GAGCAGTCCA CAATGTCACA 23001 AGACATCTCC ATAGGAACCA TCCCCAGGAT TTCTGCCTCC TCTGTCCTGA 23051 CAGAATCTGC AAAAATGACC ATCACAACCC AAACAGGTCC TTCGGAGTCT 23101 ACACTAGAAA GTACCCTTAA TTTGAACACA GCAACCACAC CCTCTTGGGT 23151 GGAAACCCAC TCTATAGTAA TTCAGGGATT TCCACACCCA GAGATGACCA 23201 CTTCCATGGG CAGAGGTCCT GGAGGTGTGT CATGGCCTAG CCCTCCCTTT 23251 GTGAAAGAAA CCAGCCCTCC ATCCTCCCCG CTGTCTTTAC CTGCCGTGAC 23301 CTCACCTCAT CCTGTTTCCA CCACATTCCT AGCACATATC CCCCCCTCTC 23351 CCCTTCCTGT GACTTCACTT CTCACCTCTG GCCCGGCGAC AACCACAGAT 23401 ATCTTGGGTA CAAGCACAGA ACCTGGAACC AGTTCATCTT CAAGTTTGAG 23451 CACCACCTCC CATGAGAGAC TGACCACTTA CAAAGACACT GCACATACAG 23501 AAGCCGTGCA TCCTTCCACA AACACAGGAG GGACCAATGT GGCAACCACC 23551 AGCTCTGGAT ATAAATCACA GTCCTCTGTC CTAGCTGACT CATCTCCAAT 23601 GTGTACCACC TCCACCATGG GGGATACAAG TGTTCTCACA TCAACTCCTG 23651 CCTTCCTTGA GACTAGGAGG ATTCAGACAG AGCTAGCTTC CTCCCTGACC 23701 CCTGGATTGA GGGAGTCCAG TGGCTCTGAA GGGACCAGCT CAGGCACCAA 23751 GATGAGCACT GTCCTCTCTA AAGTGCCCAC TGGTGCTACT ACTGAGATCT 23801 CCAAGGAAGA CGTCACCTCC ATCCCAGGTC CCGCTCAATC CACAATATCA 23851 CCAGACATCT CCACAAGAAC CGTCAGCTGG TTCTCTACAT CCCCTGTCAT 23901 GACAGAATCA GCAGAAATAA CCATGAACAC CCATACAAGT CCTTTAGGGG 23951 CCACAACACA AGGCACCAGT ACTTTGGCCA CGTCAAGCAC AACCTCTTTG 24001 ACAATGACAC ACTCAACTAT ATCTCAAGGA TTTTCACACT CACAGATGAG 24051 CACTCTTATG AGGAGGGGTC CTGAGGATGT ATCATGGATG AGCCCTCCCC 24101 TTCTGGAAAA AACTAGACCT TCCTTTTCTC TGATGTCTTC ACCAGCCACA 24151 ACTTCACCTT CTCCTGTTTC CTCCACATTA CCAGAGAGCA TCTCTTCCTC 24201 TCCTCTTCCT GTGACTTCAC TCCTCACGTC TGGCTTGGCA AAAACTACAG 24251 ATATGTTGCA CAAAAGCTCA GAACCTGTAA CCAACTCACC TGCAAATTTG 24301 AGCAGCACCT CAGTTGAAAT ACTGGCCACC TCTGAAGTCA CCACAGATAC 24351 AGAGAAAACT CATCCTTCTT CAAACAGAAC AGTGACCGAT GTGGGGACCT 24401 CCAGTTCTGG ACATGAATCC ACTTCCTTTG TCCTAGCTGA CTCACAGACA 24451 TCCAAAGTCA CATCTCCAAT GGTTATTACC TCCACCATGG AGGATACGAG 24501 TGTCTCCACA TCAACTCCTG GCTTTTTTGA GACTAGCAGA ATTCAGACAG 24551 AACCAACATC CTCCCTGACC CTTGGACTGA GAAAGACCAG CAGCTCTGAG 24601 GGGACCAGCT TAGCCACAGA GATGAGCACT GTCCTTTCTG GAGTGCCCAC 24651 TGGTGCCACT GCTGAAGTCT CCAGGACAGA AGTCACCTCC TCTAGCAGAA 24701 CATCCATCTC AGGCTTTGCT CAGCTCACAG TGTCACCAGA GACTTCCACA 24751 GAAACCATCA CCAGACTCCC TACCTCCAGC ATAATGACAG AATCAGCAGA 24801 AATGATGATC AAGACACAAA CAGATCCTCC TGGGTCTACA CCAGAGAGTA 24851 CTCATACTGT GGACATATCA ACAACACCCA ACTGGGTAGA AACCCACTCG 24901 ACTGTGACTC AGAGATTTTC ACACTCAGAG ATGACCACTC TTGTGAGCAG 24951 AAGCCCTGGT GATATGTTAT GGCCTAGTCA ATCCTCTGTG GAAGAAACCA 25001 GCTCTGCCTC TTCCCTGCTG TCTCTGCCTG CCACGACCTC ACCTTCTCCT 25051 GTTTCCTCTA CATTAGTAGA GGATTTCCCT TCCGCTTCTC TTCCTGTGAC 25101 TTCTCTTCTC ACCCCTGGCC TGGTGATAAC CACAGACAGG ATGGGCATAA 25151 GCAGAGAACC TGGAACCAGT TCCACTTCAA ATTTGAGCAG CACCTCCCAT 25201 GAGAGACTGA CCACTTTGGA AGACACTGTA GATACAGAAG ACATGCAGCC 25251 TTCCACACAC ACAGCAGTGA CCAACGTGAG GACCTCCATT TCTGGACATG 25301 AATCACAATC TTCTGTCCTA TCTGACTCAG AGACACCCAA AGCCACATCT 25351 CCAATGGGTA CCACCTACAC CATGGGGGAA ACGAGTGTTT CCATATCCAC 25401 TTCTGACTTC TTTGAGACCA GCAGAATTCA GATAGAACCA ACATCCTCCC 25451 TGACTTCTGG ATTGAGGGAG ACCAGCAGCT CTGAGAGGAT CAGCTCAGCC 25501 ACAGAGGGAA GCACTGTCCT TTCTGAAGTG CCCAGTGGTG CTACCACTGA 25551 GGTCTCCAGG ACAGAAGTGA TATCCTCTAG GGGAACATCC ATGTCAGGGC 25601 CTGATCAGTT CACCATATCA CCAGACATCT CTACTGAAGC GATCACCAGG 25651 CTTTCTACTT CCCCCATTAT GACAGAATCA GCAGAAAGTG CCATCACTAT 25701 TGAGACAGGT TCTCCTGGGG CTACATCAGA GGGTACCCTC ACCTTGGACA 25751 CCTCAACAAC AACCTTTTGG TCAGGGACCC ACTCAACTGC ATCTCCAGGA 25801 TTTTCACACT CAGAGATGAC CACTCTTATG AGTAGAACTC CTGGAGATGT 25851 GCCATGGCCG AGCCTTCCCT CTGTGGAAGA AGCCAGCTCT GTCTCTTCCT 25901 CACTGTCTTC ACCTGCCATG ACCTCAACTT CTTTTTTCTC CGCATTACCA 25951 GAGAGCATCT CCTCCTCTCC TCATCCTGTG ACTGCACTTC TCACCCTTGG 26001 CCCAGTGAAG ACCACAGACA TGTTGCGCAC AAGCTCAGAA CCTGAAACCA 26051 GTTCACCTCC AAATTTGAGC AGCACCTCAG CTGAAATATT AGCCACGTCT 26101 GAAGTCACCA AAGATAGAGA GAAAATTCAT CCCTCCTCAA ACACACCTGT 26151 AGTCAATGTA GGGACTGTGA TTTATAAACA TCTATCCCCT TCCTCTGTTT 26201 TGGCTGACTT AGTGACAACA AAACCCACAT CTCCAATGGC TACCACCTCC 26251 ACTCTGGGGA ATACAAGTGT TTCCACATCA ACTCCTGCCT TCCCAGAAAC 26301 TATGATGACA CAGCCAACTT CCTCCCTGAC TTCTGGATTA AGGGAGATCA 26351 GTACCTCTCA AGAGACCAGC TCAGCAACAG AGAGAAGTGC TTCTCTTTCT 26401 GGAATGCCCA CTGGTGCTAC TACTAAGGTC TCCAGAACAG AAGCCCTCTC 26451 CTTAGGCAGA ACATCCACCC CAGGTCCTGC TCAATCCACA ATATCACCAG 26501 AAATCTCCAC GGAAACCATC ACTAGAATTT CTACTCCCCT CACCACGACA 26551 GGATCAGCAG AAATGACCAT CACCCCCAAA ACAGGTCATT CTGGGGCATC 26601 CTCACAAGGT ACCTTTACCT TGGACACATC AAGCAGAGCC TCCTGGCCAG 26651 GAACTCACTC AGCTGCAACT CACAGATCTC CACACTCAGG GATGACCACT 26701 CCTATGAGCA GAGGTCCTGA GGATGTGTCA TGGCCAAGCC GCCCATCAGT 26751 GGAAAAAACT AGCCCTCCAT CTTCCCTGGT GTCTTTATCT GCAGTAACCT 26801 CACCTTCGCC ACTTTATTCC ACACCATCTG AGAGTAGCCA CTCATCTCCT 26851 CTCCGGGTGA CTTCTCTTTT CACCCCTGTC ATGATGAAGA CCACAGACAT 26901 GTTGGACACA AGCTTGGAAC CTGTGACCAC TTCACCTCCC AGTATGAATA 26951 TCACCTCAGA TGAGAGTCTG GCCACTTCTA AAGCCACCAT GGAGACAGAG 27001 GCAATTCAGC TTTCAGAAAA CACAGCTGTG ACTCAGATGG GCACCATCAG 27051 CGCTAGACAA GAATTCTATT CCTCTTATCC AGGCCTCCCA GAGCCATCCA 27101 AAGTGACATC TCCAGTGGTC ACCTCTTCCA CCATAAAAGA CATTGTTTCT 27151 ACAACCATAC CTGCTTCCTC TGAGATAACA AGAATTGAGA TGGAGTCAAC 27201 ATCCACCCTG ACCCCCACAC CAAGGGAGAC CAGCACCTCC CAGGAGATCC 27251 ACTCAGCCAC AAAGCCAAGC ACTGTTCCTT ACAAGGCACT CACTAGTGCC 27301 ACGATTGAGG ACTCCATGAC ACAAGTCATG TCCTCTAGCA GAGGACCTAG 27351 CCCTGATCAG TCCACAATGT CACAAGACAT ATCCAGTGAA GTGATCACCA 27401 GGCTCTCTAC CTCCCCCATC AAGGCAGAAT CTACAGAAAT GACCATTACC 27451 ACCCAAACAG GTTCTCCTGG GGCTACATCA AGGGGTACCC TTACCTTGGA 27501 CACTTCAACA ACTTTTATGT CAGGGACCCA CTCAACTGCA TCTCAAGGAT 27551 TTTCACACTC ACAGATGACC GCTCTTATGA GTAGAACTCC TGGAGATGTG 27601 CCATGGCTAA GCCATCCCTC TGTGGAAGAA GCCAGCTCTG CCTCTTTCTC 27651 ACTGTCTTCA CCTGTCATGA CCTCATCTTC TCCCGTTTCT TCCACATTAC 27701 CAGACAGCAT CCACTCTTCT TCGCTTCCTG TGACATCACT TCTCACCTCA 27751 GGGCTGGTGA AGACCACAGA GCTGTTGGGC ACAAGCTCAG AACCTGAAAC 27801 CAGTTCACCC CCAAATTTGA GCAGCACCTC AGCTGAAATA CTGGCCACCA 27851 CTGAAGTCAC TACAGATACA GAGAAACTGG AGATGACCAA TGTGGTAACC 27901 TCAGGTTATA CACATGAATC TCCTTCCTCT GTCCTAGCTG ACTCAGTGAC 27951 AACAAAGGCC ACATCTTCAA TGGGTATCAC CTACCCCACA GGAGATACAA 28001 ATGTTCTCAC ATCAACCCCT GCCTTCTCTG ACACCAGTAG GATTCAAACA 28051 AAGTCAAAGC TCTCACTGAC TCCTGGGTTG ATGGAGACCA GCATCTCTGA 28101 AGAGACCAGC TCTGCCACAG AAAAAAGCAC TGTCCTTTCT AGTGTGCCCA 28151 CTGGTGCTAC TACTGAGGTC TCCAGGACAG AAGCCATCTC TTCTAGCAGA 28201 ACATCCATCC CAGGCCCTGC TCAATCCACA ATGTCATCAG ACACCTCCAT 28251 GGAAACCATC ACTAGAATTT CTACCCCCCT CACAAGGAAA GAATCAACAG 28301 ACATGGCCAT CACCCCCAAA ACAGGTCCTT CTGGGGCTAC CTCGCAGGGT 28351 ACCTTTACCT TGGACTCATC AAGCACAGCC TCCTGGCCAG GAACTCACTC 28401 AGCTACAACT CAGAGATTTC CACAGTCAGT GGTGACAACT CCTATGAGCA 28451 GAGGTCCTGA GGATGTGTCA TGGCCAAGCC CGCTGTCTGT GGAAAAAAAC 28501 AGCCCTCCAT CTTCCCTGGT ATCTTCATCT TCAGTAACCT CACCTTCGCC 28551 ACTTTATTCC ACACCATCTG GGAGTAGCCA CTCCTCTCCT GTCCCTGTCA 28601 CTTCTCTTTT CACCTCTATC ATGATGAAGG CCACAGACAT GTTGGATGCA 28651 AGTTTGGAAC CTGAGACCAC TTCAGCTCCC AATATGAATA TCACCTCAGA 28701 TGAGAGTCTG GCCACTTCTA AAGCCACCAC GGAGACAGAG GCAATTCACG 28751 TTTTTGAAAA TACAGCAGCG TCCCATGTGG AAACCACCAG TGCTACAGAG 28801 GAACTCTATT CCTCTTCCCC AGGCTTCTCA GAGCCAACAA AAGTGATATC 28851 TCCAGTGGTC ACCTCTTCCT CTATAAGAGA CAACATGGTT TCCACAACAA 28901 TGCCTGGCTC CTCTGGCATT ACAAGGATTG AGATAGAGTC AATGTCATCT 28951 CTGACCCCTG GACTGAGGGA GACCAGAACC TCCCAGGACA TCACCTCATC 29001 CACAGAGACA AGCACTGTCC TTTACAAGAT GTCCTCTGGT GCCACTCCTG 29051 AGGTCTCCAG GACAGAAGTT ATGCCCTCTA GCAGAACATC CATTCCTGGC 29101 CCTGCTCAGT CCACAATGTC ACTAGACATC TCCGATGAAG TTGTCACCAG 29151 GCTGTCTACC TCTCCCATCA TGACAGAATC TGCAGAAATA ACCATCACCA 29201 CCCAAACAGG TTATTCTCTG GCTACATCCC AGGTTACCCT TCCCTTGGGC 29251 ACCTCAATGA CCTTTTTGTC AGGGACCCAC TCAACTATGT CTCAAGGACT 29301 TTCACACTCA GAGATGACCA ATCTTATGAG CAGGGGTCCT GAAAGTCTGT 29351 CATGGACGAG CCCTCGCTTT GTGGAAACAA CTAGATCTTC CTCTTCTCTG 29401 ACATCATTAC CTCTCACGAC CTCACTTTCT CCTGTGTCCT CCACATTACT 29451 AGACAGTAGC CCCTCCTCTC CTCTTCCTGT GACTTCACTT ATCCTCCCAG 29501 GCCTGGTGAA GACTACAGAA GTGTTGGATA CAAGCTCAGA GCCTAAAACC 29551 AGTTCATCTC CAAATTTGAG CAGCACCTCA GTTGAAATAC CGGCCACCTC 29601 TGAAATCATG ACAGATACAG AGAAAATTCA TCCTTCCTCA AACACAGCGG 29651 TGGCCAAAGT GAGGACCTCC AGTTCTGTTC ATGAATCTCA TTCCTCTGTC 29701 CTAGCTGACT CAGAAACAAC CATAACCATA CCTTCAATGG GTATCACCTC 29751 CGCTGTGGAC GATACCACTG TTTTCACATC AAATCCTGCC TTCTCTGAGA 29801 CTAGGAGGAT TCCGACAGAG CCAACATTCT CATTGACTCC TGGATTCAGG 29851 GAGACTAGCA CCTCTGAAGA GACCACCTCA ATCACAGAAA CAAGTGCAGT 29901 CCTTTATGGA GTGCCCACTA GTGCTACTAC TGAAGTCTCC ATGACAGAAA 29951 TCATGTCCTC TAATAGAACA CACATCCCTG ACTCTGATCA GTCCACGATG 30001 TCTCCAGACA TCATCACTGA AGTGATCACC AGGCTCTCTT CCTCATCCAT 30051 GATGTCAGAA TCAACACAAA TGACCATCAC CACCCAAAAA AGTTCTCCTG 30101 GGGCTACAGC ACAGAGTACT CTTACCTTGG CCACAACAAC AGCCCCCTTG 30151 GCAAGGACCC ACTCAACTGT TCCTCCTAGA TTTTTACACT CAGAGATGAC 30201 AACTCTTATG AGTAGGAGTC CTGAAAATCC ATCATGGAAG AGCTCTCCCT 30251 TTGTGGAAAA AACTAGCTCT TCATCTTCTC TGTTGTCCTT ACCTGTCACG 30301 ACCTCACCTT CTGTTTCTTC CACATTACCG CAGAGTATCC CTTCCTCCTC 30351 TTTTTCTGTG ACTTCACTCC TCACCCCAGG CATGGTGAAG ACTACAGACA 30401 CAAGCACAGA ACCTGGAACC AGTTTATCTC CAAATCTGAG TGGCACCTCA 30451 GTTGAAATAC TGGCTGCCTC TGAAGTCACC ACAGATACAG AGAAAATTCA 30501 TCCTTCTTCA AGCATGGCAG TGACCAATGT GGGAACCACC AGTTCTGGAC 30551 ATGAACTATA TTCCTCTGTT TCAATCCACT CGGAGCCATC CAAGGCTACA 30601 TACCCAGTGG GTACTCCCTC TTCCATGGCT GAAACCTCTA TTTCCACATC 30651 AATGCCTGCT AATTTTGAGA CCACAGGATT TGAGGCTGAG CCATTTTCTC 30701 ATTTGACTTC TGGATTTAGG AAGACAAACA TGTCCCTGGA CACCAGCTCA 30751 GTCACACCAA CAAATACACC TTCTTCTCCT GGGTCCACTC ACCTTTTACA 30801 GAGTTCCAAG ACTGATTTCA CCTCTTCTGC AAAAACATCA TCCCCAGACT 30851 GGCCTCCAGC CTCACAGTAT ACTGAAATTC CAGTGGACAT AATCACCCCC 30901 TTTAATGCTT CTCCATCTAT TACGGAGTCC ACTGGGATAA CCTCCTTCCC 30951 AGAATCCAGG TTTACTATGT CTGTAACAGA AAGTACTCAT CATCTGAGTA 31001 CAGATTTGCT GCCTTCAGCT GAGACTATTT CCACTGGCAC AGTGATGCCT 31051 TCTCTATCAG AGGCCATGAC TTCATTTGCC ACCACTGGAG TTCCACGAGC 31101 CATCTCAGGT TCAGGTAGTC CATTCTCTAG GACAGAGTCA GGCCCTGGGG 31151 ATGCTACTCT GTCCACCATT GCAGAGAGCC TGCCTTCATC CACTCCTGTG 31201 CCATTCTCCT CTTCAACCTT CACTACCACT GATTCTTCAA CCATCCCAGC 31251 CCTCCATGAG ATAACTTCCT CTTCAGCTAC CCCATATAGA GTGGACACCA 31301 GTCTTGGGAC AGAGAGCAGC ACTACTGAAG GACGCTTGGT TATGGTCAGT 31351 ACTTTGGACA CTTCAAGCCA ACCAGGCAGG ACATCTTCAA CACCCATTTT 31401 GGATACCAGA ATGACAGAGA GCGTTGAGCT GGGAACAGTG ACAAGTGCTT 31451 ATCAAGTTCC TTCACTCTCA ACACGGTTGA CAAGAACTGA TGGCATTATG 31501 GAACACATCA CAAAAATACC CAATGAAGCA GCACACAGAG GTACCATAAG 31551 ACCAGTCAAA GGCCCTCAGA CATCCACTTC GCCTGCCAGT CCTAAAGGAC 31601 TACACACAGG AGGGACAAAA AGAATGGAGA CCACCACCAC AGCTTTGAAG 31651 ACCACCACCA CAGCTTTGAA GACCACTTCC AGAGCCACCT TGACCACCAG 31701 TGTCTATACT CCCACTTTGG GAACACTGAC TCCCCTCAAT GCATCAAGGC 31751 AAATGGCCAG CACAATCCTC ACAGAAATGA TGATCACAAC CCCATATGTT 31801 TTCCCTGATG TTCCAGAAAC GACATCCTCA TTGGCTACCA GCCTGGGAGC 31851 AGAAACCAGC ACAGCTCTTC CCAGGACAAC CCCATCTGTT CTCAATAGAG 31901 AATCAGAGAC CACAGCCTCA CTGGTCTCTC GTTCTGGGGC AGAGAGAAGT 31951 CCGGTTATTC AAACTCTAGA TGTTTCTTCT AGTGAGCCAG ATACAACAGC 32001 TTCATGGGTT ATCCATCCTG CAGAGACCAT CCCAACTGTT TCCAAGACAA 32051 CCCCCAATTT TTTCCACAGT GAATTAGACA CTGTATCTTC CACAGCCACC 32101 AGTCATGGGG CAGACGTCAG CTCAGCCATT CCAACAAATA TCTCACCTAG 32151 TGAACTAGAT GCACTGACCC CACTGGTCAC TATTTCGGGG ACAGATACTA 32201 GTACAACATT CCCAACACTG ACTAAGTCCC CACATGAAAC AGAGACAAGA 32251 ACCACATGGC TCACTCATCC TGCAGAGACC AGCTCAACTA TTCCCAGAAC 32301 AATCCCCAAT TTTTCTCATC ATGAATCAGA TGCCACACCT TCAATAGCCA 32351 CCAGTCCTGG GGCAGAAACC AGTTCAGCTA TTCCAATTAT GACTGTCTCA 32401 CCTGGTGCAG AAGATCTGGT GACCTCACAG GTCACTAGTT CTGGGACAGA 32451 CAGAAATATG ACTATTCCAA CTTTGACTCT TTCTCCTGGT GAACCAAAGA 32501 CGATAGCCTC ATTAGTCACC CATCCTGAAG CACAGACAAG TTCGGCCATT 32551 CCAACTTCAA CTATCTCGCC TGCTGTATCA CGGTTGGTGA CCTCAATGGT 32601 CACCAGTTTG GCGGCAAAGA CAAGTACAAC TAATCGAGCT CTGACAAACT 32651 CCCCTGGTGA ACCAGCTACA ACAGTTTCAT TGGTCACGCA TCCTGCACAG 32701 ACCAGCCCAA CAGTTCCCTG GACAACTTCC ATTTTTTTCC ATAGTAAATC 32751 AGACACCACA CCTTCAATGA CCACCAGTCA TGGGGCAGAA TCCAGTTCAG 32801 CTGTTCCAAC TCCAACTGTT TCAACTGAGG TACCAGGAGT AGTGACCCCT 32851 TTGGTCACCA GTTCTAGGGC AGTGATCAGT ACAACTATTC CAATTCTGAC 32901 TCTTTCTCCT GGTGAACCAG AGACCACACC TTCAATGGCC ACCAGTCATG 32951 GGGAAGAAGC CAGTTCTGCT ATTCCAACTC CAACTGTTTC ACCTGGGGTA 33001 CCAGGAGTGG TGACCTCTCT GGTCACTAGT TCTAGGGCAG TGACTAGTAC 33051 AACTATTCCA ATTCTGACTT TTTCTCTTGG TGAACCAGAG ACCACACCTT 33101 CAATGGCCAC CAGTCATGGG ACAGAAGCTG GCTCAGCTGT TCCAACTGTT 33151 TTACCTGAGG TACCAGGAAT GGTGACCTCT CTGGTTGCTA GTTCTAGGGC 33201 AGTAACCAGT ACAACTCTTC CAACTCTGAC TCTTTCTCCT GGTGAACCAG 33251 AGACCACACC TTCAATGGCC ACCAGTCATG GGGCAGAAGC CAGCTCAACT 33301 GTTCCAACTG TTTCACCTGA GGTACCAGGA GTGGTGACCT CTCTGGTCAC 33351 TAGTTCTAGT GGAGTAAACA GTACAAGTAT TCCAACTCTG ATTCTTTCTC 33401 CTGGTGAACT AGAAACCACA CCTTCAATGG CCACCAGTCA TGGGGCAGAA 33451 GCCAGCTCAG CTGTTCCAAC TCCAACTGTT TCACCTGGGG TATCAGGAGT 33501 GGTGACCCCT CTGGTCACTA GTTCCAGGGC AGTGACCAGT ACAACTATTC 33551 CAATTCTAAC TCTTTCTTCT AGTGAGCCAG AGACCACACC TTCAATGGCC 33601 ACCAGTCATG GGGTAGAAGC CAGCTCAGCT GTTCTAACTG TTTCACCTGA 33651 GGTACCAGGA ATGGTGACCT CTCTGGTCAC TAGTTCTAGA GCAGTAACCA 33701 GTACAACTAT TCCAACTCTG ACTATTTCTT CTGATGAACC AGAGACCACA 33751 ACTTCATTGG TCACCCATTC TGAGGCAAAG ATGATTTCAG CCATTCCAAC 33801 TTTAGCTGTC TCCCCTACTG TACAAGGGCT GGTGACTTCA CTGGTCACTA 33851 GTTCTGGGTC AGAGACCAGT GCGTTTTCAA ATCTAACTGT TGCCTCAAGT 33901 CAACCAGAGA CCATAGACTC ATGGGTCGCT CATCCTGGGA CAGAAGCAAG 33951 TTCTGTTGTT CCAACTTTGA CTGTCTCCAC TGGTGAGCCG TTTACAAATA 34001 TCTCATTGGT CACCCATCCT GCAGAGAGTA GCTCAACTCT TCCCAGGACA 34051 ACCTCAAGGT TTTCCCACAG TGAATTAGAC ACTATGCCTT CTACAGTCAC 34101 CAGTCCTGAG GCAGAATCCA GCTCAGCCAT TTCAACTACT ATTTCACCTG 34151 GTATACCAGG TGTGCTGACA TCACTGGTCA CTAGCTCTGG GAGAGACATC 34201 AGTGCAACTT TTCCAACAGT GCCTGAGTCC CCACATGAAT CAGAGGCAAC 34251 AGCCTCATGG GTTACTCATC CTGCAGTCAC CAGCACAACA GTTCCCAGGA 34301 CAACCCCTAA TTATTCTCAT AGTGAACCAG ACACCACACC ATCAATAGCC 34351 ACCAGTCCTG GGGCAGAAGC CACTTCAGAT TTTCCAACAA TAACTGTCTC 34401 ACCTGATGTA CCAGATATGG TAACCTCACA GGTCACTAGT TCTGGGACAG 34451 ACACCAGTAT AACTATTCCA ACTCTGACTC TTTCTTCTGG TGAGCCAGAG 34501 ACCACAACCT CATTTATCAC CTATTCTGAG ACACACACAA GTTCAGCCAT 34551 TCCAACTCTC CCTGTCTCCC CTGGTGCATC AAAGATGCTG ACCTCACTGG 34601 TCATCAGTTC TGGGACAGAC AGCACTACAA CTTTCCCAAC ACTGACGGAG 34651 ACCCCATATG AACCAGAGAC AACAGCCATA CAGCTCATTC ATCCTGCAGA 34701 GACCAACACA ATGGTTCCCA AGACAACTCC CAAGTTTTCC CATAGTAAGT 34751 CAGACACCAC ACTCCCAGTA GCCATCACCA GTCCTGGGCC AGAAGCCAGT 34801 TCAGCTGTTT CAACGACAAC TATCTCACCT GATATGTCAG ATCTGGTGAC 34851 CTCACTGGTC CCTAGTTCTG GGACAGACAC CAGTACAACC TTCCCAACAT 34901 TGAGTGAGAC CCCATATGAA CCAGAGACTA CAGTCACGTG GCTCACTCAT 34951 CCTGCAGAAA CCAGCACAAC GGTTTCTGGG ACAATTCCCA ACTTTTCCCA 35001 TAGGGGATCA GACACTGCAC CCTCAATGGT CACCAGTCCT GGAGTAGACA 35051 CGAGGTCAGG TGTTCCAACT ACAACCATCC CACCCAGTAT ACCAGGGGTA 35101 GTGACCTCAC AGGTCACTAG TTCTGCAACA GACACTAGTA CAGCTATTCC 35151 AACTTTGACT CCTTCTCCTG GTGAACCAGA GACCACAGCC TCATCAGCTA 35201 CCCATCCTGG GACACAGACT GGCTTCACTG TTCCAATTCG GACTGTTCCC 35251 TCTAGTGAGC CAGATACAAT GGCTTCCTGG GTCACTCATC CTCCACAGAC 35301 CAGCACACCT GTTTCCAGAA CAACCTCCAG TTTTTCCCAT AGTAGTCCAG 35351 ATGCCACACC TGTAATGGCC ACCAGTCCTA GGACAGAAGC CAGTTCAGCT 35401 GTACTGACAA CAATCTCACC TGGTGCACCA GAGATGGTGA CTTCACAGAT 35451 CACTAGTTCT GGGGCAGCAA CCAGTACAAC TGTTCCAACT TTGACTCATT 35501 CTCCTGGTAT GCCAGAGACC ACAGCCTTAT TGAGCACCCA TCCCAGAACA 35551 GGGACAAGTA AAACATTTCC TGCTTCAACT GTGTTTCCTC AAGTATCAGA 35601 GACCACAGCC TCACTCACCA TTAGACCTGG TGCAGAGACT AGCACAGCTC 35651 TCCCAACTCA GACAACATCC TCTCTCTTCA CCCTACTTGT AACTGGAACC 35701 AGCAGAGTTG ATCTAAGTCC AACTGCTTCA CCTGGTGTTT CTGCAAAAAC 35751 AGCCCCACTT TCCACCCATC CAGGGACAGA GACCAGCACA ATGATTCCAA 35801 CTTCAACTCT TTCCCTTGGT TTACTAGAGA CTACAGGCTT ACTGGCCACC 35851 AGCTCTTCAG CAGAGACCAG CACGAGTACT CTAACTCTGA CTGTTTCCCC 35901 TGCTGTCTCT GGGCTTTCCA GTGCCTCTAT AACAACTGAT AAGCCCCAAA 35951 CTGTGACCTC CTGGAACACA GAAACCTCAC CATCTGTAAC TTCAGTTGGA 36001 CCCCCAGAAT TTTCCAGGAC TGTCACAGGC ACCACTATGA CCTTGATACC 36051 ATCAGAGATG CCAACACCAC CTAAAACCAG TCATGGAGAA GGAGTGAGTC 36101 CAACCACTAT CTTGAGAACT ACAATGGTTG AAGCCACTAA TTTAGCTACC 36151 ACAGGTTCCA GTCCCACTGT GGCCAAGACA ACAACCACCT TCAATACACT 36201 GGCTGGAAGC CTCTTTACTC CTCTGACCAC ACCTGGGATG TCCACCTTGG 36251 CCTCTGAGAG TGTGACCTCA AGAACAAGTT ATAACCATCG GTCCTGGATC 36301 TCCACCACCA GCAGTTATAA CCGTCGGTAC TGGACCCCTG CCACCAGCAC 36351 TCCAGTGACT TCTACATTCT CCCCAGGGAT TTCCACATCC TCCATCCCCA 36401 GCTCCACAGC AGCCACAGTC CCATTCATGG TGCCATTCAC CCTCAACTTC 36451 ACCATCACCA ACCTGCAGTA CGAGGAGGAC ATGCGGCACC CTGGTTCCAG 36501 GAAGTTCAAC GCCACAGAGA GAGAACTGCA GGGTCTGCTC AAACCCTTGT 36551 TCAGGAATAG CAGTCTGGAA TACCTCTATT CAGGCTGCAG ACTAGCCTCA 36601 CTCAGGCCAG AGAAGGATAG CTCAGCCATG GCAGTGGATG CCATCTGCAC 36651 ACATCGCCCT GACCCTGAAG ACCTCGGACT GGACAGAGAG CGACTGTACT 36701 GGGAGCTGAG CAATCTGACA AATGGCATCC AGGAGCTGGG CCCCTACACC 36751 CTGGACCGGA ACAGTCTCTA TGTCAATGGT TTCACCCATC GAAGCTCTAT 36801 GCCCACCACC AGCACTCCTG GGACCTCCAC AGTGGATGTG GGAACCTCAG 36851 GGACTCCATC CTCCAGCCCC AGCCCCACGG CTGCTGGCCC TCTCCTGATG 36901 CCGTTCACCC TCAACTTCAC CATCACCAAC CTGCAGTACG AGGAGGACAT 36951 GCGTCGCACT GGCTCCAGGA AGTTCAACAC CATGGAGAGT GTCCTGCAGG 37001 GTCTGCTCAA GCCCTTGTTC AAGAACACCA GTGTTGGCCC TCTGTACTCT 37051 GGCTGCAGAT TGACCTTGCT CAGGCCCGAG AAAGATGGGG CAGCCACTGG 37101 AGTGGATGCC ATCTGCACCC ACCGCCTTGA CCCCAAAAGC CCTGGACTCA 37151 ACAGGGAGCA GCTGTACTGG GAGCTAAGCA AACTGACCAA TGACATTGAA 37201 GAGCTGGGCC CCTACACCCT GGACAGGAAC AGTCTCTATG TCAATGGTTT 37251 CACCCATCAG AGCTCTGTGT CCACCACCAG CACTCCTGGG ACCTCCACAG 37301 TGGATCTCAG AACCTCAGGG ACTCCATCCT CCCTCTCCAG CCCCACAATT 37351 ATGGCTGCTG GCCCTCTCCT GGTACCATTC ACCCTCAACT TCACCATCAC 37401 CAACCTGCAG TATGGGGAGG ACATGGGTCA CCCTGGCTCC AGGAAGTTCA 37451 ACACCACAGA GAGGGTCCTG CAGGGTCTGC TTGGTCCCAT ATTCAAGAAC 37501 ACCAGTGTTG GCCCTCTGTA CTCTGGCTGC AGACTGACCT CTCTCAGGTC 37551 TGAGAAGGAT GGAGCAGCCA CTGGAGTGGA TGCCATCTGC ATCCATCATC 37601 TTGACCCCAA AAGCCCTGGA CTCAACAGAG AGCGGCTGTA CTGGGAGCTG 37651 AGCCAACTGA CCAATGGCAT CAAAGAGCTG GGCCCCTACA CCCTGGACAG 37701 GAACAGTCTC TATGTCAATG GTTTCACCCA TCGGACCTCT GTGCCCACCA 37751 CCAGCACTCC TGGGACCTCC ACAGTGGACC TTGGAACCTC AGGGACTCCA 37801 TTCTCCCTCC CAAGCCCCGC AACTGCTGGC CCTCTCCTGG TGCTGTTCAC 37851 CCTCAACTTC ACCATCACCA ACCTGAAGTA TGAGGAGGAC ATGCATCGCC 37901 CTGGCTCCAG GAAGTTCAAC ACCACTGAGA GGGTCCTGCA GACTCTGCTT 37951 GGTCCTATGT TCAAGAACAC CAGTGTTGGC CTTCTGTACT CTGGCTGCAG 38001 ACTGACCTTG CTCAGGTCCG AGAAGGATGG AGCAGCCACT GGAGTGGATG 38051 CCATCTGCAC CCACCGTCTT GACCCCAAAA GCCCTGGACT GGACAGAGAG 38101 CAGCTATACT GGGAGCTGAG CCAGCTGACC AATGGCATCA AAGAGCTGGG 38151 CCCCTACACC CTGGACAGGA ACAGTCTCTA TGTCAATGGT TTCACCCATT 38201 GGATCCCTGT GCCCACCAGC AGCACTCCTG GGACCTCCAC AGTGGACCTT 38251 GGGTCAGGGA CTCCATCCTC CCTCCCCAGC CCCACAGCTG CTGGCCCTCT 38301 CCTGGTGCCA TTCACCCTCA ACTTCACCAT CACCAACCTG CAGTACGAGG 38351 AGGACATGCA TCACCCAGGC TCCAGGAAGT TCAACACCAC GGAGCGGGTC 38401 CTGCAGGGTC TGCTTGGTCC CATGTTCAAG AACACCAGTG TCGGCCTTCT 38451 GTACTCTGGC TGCAGACTGA CCTTGCTCAG GTCCGAGAAG GATGGAGCAG 38501 CCACTGGAGT GGATGCCATC TGCACCCACC GTCTTGACCC CAAAAGCCCT 38551 GGAGTGGACA GGGAGCAGCT ATACTGGGAG CTGAGCCAGC TGACCAATGG 38601 CATCAAAGAG CTGGGTCCCT ACACCCTGGA CAGAAACAGT CTCTATGTCA 38651 ATGGTTTCAC CCATCAGACC TCTGCGCCCA ACACCAGCAC TCCTGGGACC 38701 TCCACAGTGG ACCTTGGGAC CTCAGGGACT CCATCCTCCC TCCCCAGCCC 38751 TACATCNGCT GGCCCTCTCC TGGTNCCNTT CACCCTCAAC TTCACCATCA 38801 CCAACCTGCA GTACGAGGAG GACATGCGGC ACCCNGGNTC CAGGAAGTTC 38851 AACACCACNG AGAGGGTNCT GCAGGGTCTG CTNAAGCCCC TNTTCAAGAG 38901 CACCAGTGTT GGCCCTCTGT ACTCTGGCTG CAGACTGACC TTGCTCAGGT 38951 CCGAGAAGGA TGGAGCAGCC ACTGGAGTGG ATGCCATCTG CACCCACCGT 39001 CTTGACCCCA AAAGCCCTGG AGTGGACAGG GAGCAGCTAT ACTGGGAGCT 39051 GAGCCAGCTG ACCAATGGCA TCAAAGAGCT GGGTCCCTAC ACCCTGGACA 39101 GAAACAGTCT CTATGTCAAT GGTTTCACCC ATCAGACCTC TGCGCCCAAC 39151 ACCAGCACTC CTGGGACCTC CACAGTGGAC CTTGGGACCT CAGGGACTCC 39201 ATCCTCCCTC CCCAGCCCTA CATCTGCTGG CCCTCTCCTG GTGCCATTCA 39251 CCCTCAACTT CACCATCACC AACCTGCAGT ACGAGGAGGA CATGCATCAC 39301 CCAGGCTCCA GGAAGTTCAA CACCACGGAG CGGGTCCTGC AGGGTCTGCT 39351 TGGTCCCATG TTCAAGAACA CCAGTGTCGG CCTTCTGTAC TCTGGCTGCA 39401 GACTGACCTT GCTCAGGCCT GAGAAGAATG GGGCAGCCAC TGGAATGGAT 39451 GCCATCTGCA GCCACCGTCT TGACCCCAAA AGCCCTGGAC TCAACAGAGA 39501 GCAGCTGTAC TGGGAGCTGA GCCAGCTGAC CCATGGCATC AAAGAGCTGG 39551 GCCCCTACAC CCTGGACAGG AACAGTCTCT ATGTCAATGG TTTCACCCAT 39601 CGGAGCTCTG TGGCCCCCAC CAGCACTCCT GGGACCTCCA CAGTGGACCT 39651 TGGGACCTCA GGGACTCCAT CCTCCCTCCC CAGCCCCACA ACAGCTGTTC 39701 CTCTCCTGGT GCCGTTCACC CTCAACTTTA CCATCACCAA TCTGCAGTAT 39751 GGGGAGGACA TGCGTCACCC TGGCTCCAGG AAGTTCAACA CCACAGAGAG 39801 GGTCCTGCAG GGTCTGCTTG GTCCCTTGTT CAAGAACTCC AGTGTCGGCC 39851 CTCTGTACTC TGGCTGCAGA CTGATCTCTC TCAGGTCTGA GAAGGATGGG 39901 GCAGCCACTG GAGTGGATGC CATCTGCACC CACCACCTTA ACCCTCAAAG 39951 CCCTGGACTG GACAGGGAGC AGCTGTACTG GCAGCTGAGC CAGATGACCA 40001 ATGGCATCAA AGAGCTGGGC CCCTACACCC TGGACCGGAA CAGTCTCTAC 40051 GTCAATGGTT TCACCCATCG GAGCTCTGGG CTCACCACCA GCACTCCTTG 40101 GACTTCCACA GTTGACCTTG GAACCTCAGG GACTCCATCC CCCGTCCCCA 40151 GCCCCACAAC TGCTGGCCCT CTCCTGGTGC CATTCACCCT CAACTTCACC 40201 ATCACCAACC TGCAGTATGA GGAGGACATG CATCGCCCTG GATCTAGGAA 40251 GTTCAACACC ACAGAGAGGG TCCTGCAGGG TCTGCTTAGT CCCATTTTCA 40301 AGAACTCCAG TGTTGGCCCT CTGTACTCTG GCTGCAGACT GACCTCTCTC 40351 AGGCCCGAGA AGGATGGGGC AGCAACTGGA ATGGATGCTG TCTGCCTCTA 40401 CCACCCTAAT CCCAAAAGAC CTGGACTGGA CAGAGAGCAG CTGTACTGGG 40451 AGCTAAGCCA GCTGACCCAC AACATCACTG AGCTGGGCCC CTACAGCCTG 40501 GACAGGGACA GTCTCTATGT CAATGGTTTC ACCCATCAGA ACTCTGTGCC 40551 CACCACCAGT ACTCCTGGGA CCTCCACAGT GTACTGGGCA ACCACTGGGA 40601 CTCCATCCTC CTTCCCCGGC CACACAGAGC CTGGCCCTCT CCTGATACCA 40651 TTCACTTTCA ACTTTACCAT CACCAACCTG CATTATGAGG AAAACATGCA 40701 ACACCCTGGT TCCAGGAAGT TCAACACCAC GGAGAGGGTT CTGCAGGGTC 40751 TGCTCAAGCC CTTGTTCAAG AACACCAGTG TTGGCCCTCT GTACTCTGGC 40801 TGCAGACTGA CCTCTCTCAG GCCCGAGAAG GATGGGGCAG CAACTGGAAT 40851 GGATGCTGTC TGCCTCTACC ACCCTAATCC CAAAAGACCT GGGCTGGACA 40901 GAGAGCAGCT GTACTGGGAG CTAAGCCAGC TGACCCACAA CATCACTGAG 40951 CTGGGCCCCT ACAGCCTGGA CAGGGACAGT CTCTATGTCA ATGGTTTCAC 41001 CCATCAGAAC TCTGTGCCCA CCACCAGTAC TCCTGGGACC TCCACAGTGT 41051 ACTGGGCAAC CACTGGGACT CCATCCTCCT TCCCCGGCCA CACAGAGCCT 41101 GGCCCTCTCC TGATACCATT CACTTTCAAC TTTACCATCA CCAACCTGCA 41151 TTATGAGGAA AACATGCAAC ACCCTGGTTC CAGGAAGTTC AACACCACGG 41201 AGAGGGTTCT GCAGGGTCTG CTCAAGCCCT TGTTCAAGAA CACCAGTGTT 41251 GGCCCTCTGT ACTCTGGCTG CAGACTGACC TTGCTCAGAC CTGAGAAGCA 41301 TGAGGCAGCC ACTGGAGTGG ACACCATCTG TACCCACCGC GTTGATCCCA 41351 TCGGACCTGG ACTGGACAGG GAGCGGCTAT ACTGGGAGCT GAGCCAGCTG 41401 ACCAACAGCA TTACCGAACT GGGACCCTAC ACCCTGGACA GGGACAGTCT 41451 CTATGTCAAT GGCTTCAACC CTCGGAGCTC TGTGCCAACC ACCAGCACTC 41501 CTGGGACCTC CACAGTGCAC CTGGCAACCT CTGGGACTCC ATCCTCCCTG 41551 CCTGGCCACA CAGCCCCTGT CCCTCTCTTG ATACCATTCA CCCTCAACTT 41601 TACCATCACC AACCTGCATT ATGAGGAAAA CATGCAACAC CCTGGTTCCA 41651 GGAAGTTCAA CACCACGGAG AGGGTTCTGC AGGGTCTGCT CAAGCCCTTG 41701 TTCAAGAACA CCAGTGTTGG CCCTCTGTAC TCTGGCTGCA GACTGACCTT 41751 GCTCAGACCT GAGAAGCATG AGGCAGCCAC TGGAGTGGAC ACCATCTGTA 41801 CCCACCGCGT TGATCCCATC GGACCTGGAC TGNACAGNGA GCNGCTNTAC 41851 TGGGAGCTNA GCCANCTGAC CAANNNCATC NNNGAGCTGG GNCCCTACAC 41901 CCTGGACAGG NACAGTCTCT ATGTCAATGG TTTCACCCAT CNGANCTCTG 41951 NGCCCACCAC CAGCACTCCT GGGACCTCCA CAGTGNACNT NGGNACCTCN 42001 GGGACTCCAT CCTCCNTCCC CNGCCNCACA TCTGCTGGCC CTCTCCTGGT 42051 GCCATTCACC CTCAACTTCA CCATCACCAA CCTGCAGTAC GAGGAGGACA 42101 TGCATCACCC AGGCTCCAGG AAGTTCAACA CCACGGAGCG GGTCCTGCAG 42151 GGTCTGCTTG GTCCCATGTT CAAGAACACC AGTGTCGGCC TTCTGTACTC 42201 TGGCTGCAGA CTGACCTTGC TCAGGCCTGA GAAGAATGGG GCAGCCACTG 42251 GAATGGATGC CATCTGCAGC CACCGTCTTG ACCCCAAAAG CCCTGGACTC 42301 GACAGAGAGC AGCTGTACTG GGAGCTGAGC CAGCTGACCC ATGGCATCAA 42351 AGAGCTGGGC CCCTACACCC TGGACAGGAA CAGTCTCTAT GTCAATGGTT 42401 TCACCCATCG GAGCTCTGTG GCCCCCACCA GCACTCCTGG GACCTCCACA 42451 GTGGACCTTG GGACCTCAGG GACTCCATCC TCCCTCCCCA GCCCCACAAC 42501 AGCTGTTCCT CTCCTGGTGC CGTTCACCCT CAACTTTACC ATCACCAATC 42551 TGCAGTATGG GGAGGACATG CGTCACCCTG GCTCCAGGAA GTTCAACACC 42601 ACAGAGAGGG TCCTGCAGGG TCTGCTTGGT CCCTTGTTCA AGAACTCCAG 42651 TGTCGGCCCT CTGTACTCTG GCTGCAGACT GATCTCTCTC AGGTCTGAGA 42701 AGGATGGGGC AGCCACTGGA GTGGATGCCA TCTGCACCCA CCACCTTAAC 42751 CCTCAAAGCC CTGGACTGGA CAGGGAGCAG CTGTACTGGC AGCTGAGCCA 42801 GATGACCAAT GGCATCAAAG AGCTGGGCCC CTACACCCTG GACCGGAACA 42851 GTCTCTACGT CAATGGTTTC ACCCATCGGA GCTCTGGGCT CACCACCAGC 42901 ACTCCTTGGA CTTCCACAGT TGACCTTGGA ACCTCAGGGA CTCCATCCCC 42951 CGTCCCCAGC CCCACAACTG CTGGCCCTCT CCTGGTGCCA TTCACCCTAA 43001 ACTTCACCAT CACCAACCTG CAGTATGAGG AGGACATGCA TCGCCCTGGA 43051 TCTAGGAAGT TCAACGCCAC AGAGAGGGTC CTGCAGGGTC TGCTTAGTCC 43101 CATATTCAAG AACTCCAGTG TTGGCCCTCT GTACTCTGGC TGCAGACTGA 43151 CCTCTCTCAG GCCCGAGAAG GATGGGGCAG CAACTGGAAT GGATGCTGTC 43201 TGCCTCTACC ACCCTAATCC CAAAAGACCT GGACTGGACA GAGAGCAGCT 43251 GTACTGGGAG CTAAGCCAGC TGACCCACAA CATCACTGAG CTGGGCCCCT 43301 ACAGCCTGGA CAGGGACAGT CTCTATGTCA ATGGTTTCAC CCATCAGAGC 43351 TCTATGACGA CCACCAGAAC TCCTGATACC TCCACAATGC ACCTGGCAAC 43401 CTCGAGAACT CCAGCCTCCC TGTCTGGACC TACGACCGCC AGCCCTCTCC 43451 TGGTGCTATT CACAATCAAC TGCACCATCA CCAACCTGCA GTACGAGGAG 43501 GACATGCGTC GCACTGGCTC CAGGAAGTTC AACACCATGG AGAGTGTCCT 43551 GCAGGGTCTG CTCAAGCCCT TGTTCAAGAA CACCAGTGTT GGCCCTCTGT 43601 ACTCTGGCTG CAGATTGACC TTGCTCAGGC CCAAGAAAGA TGGGGCAGCC 43651 ACTGGAGTGG ATGCCATCTG CACCCACCGC CTTGACCCCA AAAGCCCTGG 43701 ACTCAACAGG GAGCAGCTGT ACTGGGAGCT AAGCAAACTG ACCAATGACA 43751 TTGAAGAGCT GGGCCCCTAC ACCCTGGACA GGAACAGTCT CTATGTCAAT 43801 GGTTTCACCC ATCAGAGCTC TGTGTCCACC ACCAGCACTC CTGGGACCTC 43851 CACAGTGGAT CTCAGAACCT CAGGGACTCC ATCCTCCCTC TCCAGCCCCA 43901 CAATTATGNC NNCTGNCCCT CTCCTGNTNC CNTTCACCNT CAACTTNACC 43951 ATCACCAACC TGCANTANGN GGANNACATG CNNCNCCCNG GNTCCAGGAA 44001 GTTCAACACC ACNGAGAGGG TCCTACAGGG TCTGCTCAGG CCCTTGTTCA 44051 AGAACACCAG TGTCAGCTCT CTGTACTCTG GTTGCAGACT GACCTTGCTC 44101 AGGCCTGAGA AGGATGGGGC AGCCACCAGA GTGGATGCTG CCTGCACCTA 44151 CCGCCCTGAT CCCAAAAGCC CTGGACTGGA CAGAGAGCAA CTATACTGGG 44201 AGCTGAGCCA GCTAACCCAC AGCATCACTG AGCTGGGACC CTACACCCTG 44251 GACAGGGTCA GTCTCTATGT CAATGGCTTC AACCCTCGGA GCTCTGTGCC 44301 AACCACCAGC ACTCCTGGGA CCTCCACAGT GCACCTGGCA ACCTCTGGGA 44351 CTCCATCCTC CCTGCCTGGC CACACANCNN CTGNCCCTCT CCTGNTNCCN 44401 TTCACCNTCA ACTTNACCAT CACCAACCTG CANTANGNGG ANNACATGCN 44451 NCNCCCNGGN TCCAGGAAGT TCAACACCAC NGAGAGGGTT CTGCAGGGTC 44501 TGCTCAAACC CTTGTTCAGG AATAGCAGTC TGGAATACCT CTATTCAGGC 44551 TGCAGACTAG CCTCACTCAG GCCAGAGAAG GATAGCTCAG CCATGGCAGT 44601 GGATGCCATC TGCACACATC GCCCTGACCC TGAAGACCTC GGACTGGACA 44651 GAGAGCGACT GTACTGGGAG CTGAGCAATC TGACAAATGG CATCCAGGAG 44701 CTGGGCCCCT ACACCCTGGA CCGGAACAGT CTCTACGTCA ATGGTTTCAC 44751 CCATCGGAGC TCTGGGCTCA CCACCAGCAC TCCTTGGACT TCCACAGTTG 44801 ACCTTGGAAC CTCAGGGACT CCATCCCCCG TCCCCAGCCC CACAACTGCT 44851 GGCCCTCTCC TGGTGCCATT CACCCTCAAC TTCACCATCA CCAACCTGCA 44901 GTATGAGGAG GACATGCATC GCCCTGGTTC CAGGAGGTTC AACACCACGG 44951 AGAGGGTTCT GCAGGGTCTG CTCACGCCCT TGTTCAAGAA CACCAGTGTT 45001 GGCCCTCTGT ACTCTGGCTG CAGACTGACC TTGCTCAGAC CTGAGAAGCA 45051 AGAGGCAGCC ACTGGAGTGG ACACCATCTG TACCCACCGC GTTGATCCCA 45101 TCGGACCTGG ACTGGACAGA GAGCGGCTAT ACTGGGAGCT GAGCCAGCTG 45151 ACCAACAGCA TCACAGAGCT GGGACCCTAC ACCCTGGATA GGGACAGTCT 45201 CTATGTCAAT GGCTTCAACC CTTGGAGCTC TGTGCCAACC ACCAGCACTC 45251 CTGGGACCTC CACAGTGCAC CTGGCAACCT CTGGGACTCC ATCCTCCCTG 45301 CCTGGCCACA CAGCCCCTGT CCCTCTCTTG ATACCATTCA CCCTCAACTT 45351 TACCATCACC GACCTGCATT ATGAAGAAAA CATGCAACAC CCTGGTTCCA 45401 GGAAGTTCAA CACCACGGAG AGGGTTCTGC AGGGTCTGCT CAAGCCCTTG 45451 TTCAAGAGCA CCAGCGTTGG CCCTCTGTAC TCTGGCTGCA GACTGACCTT 45501 GCTCAGACCT GAGAAACATG GGGCAGCCAC TGGAGTGGAC GCCATCTGCA 45551 CCCTCCGCCT TGATCCCACT GGTCCTGGAC TGGACAGAGA GCGGCTATAC 45601 TGGGAGCTGA GCCAGCTGAC CAACAGCGTT ACAGAGCTGG GCCCCTACAC 45651 CCTGGACAGG GACAGTCTCT ATGTCAATGG CTTCACCCAT CGGAGCTCTG 45701 TGCCAACCAC CAGTATTCCT GGGACCTCTG CAGTGCACCT GGAAACCTCT 45751 GGGACTCCAG CCTCCCTCCC TGGCCACACA GCCCCTGGCC CTCTCCTGGT 45801 GCCATTCACC CTCAACTTCA CTATCACCAA CCTGCAGTAT GAGGAGGACA 45851 TGCGTCACCC TGGTTCCAGG AAGTTCAGCA CCACGGAGAG AGTCCTGCAG 45901 GGTCTGCTCA AGCCCTTGTT CAAGAACACC AGTGTCAGCT CTCTGTACTC 45951 TGGTTGCAGA CTGACCTTGC TCAGGCCTGA GAAGGATGGG GCAGCCACCA 46001 GAGTGGATGC TGTCTGCACC CATCGTCCTG ACCCCAAAAG CCCTGGACTG 46051 GACAGAGAGC GGCTGTACTG GAAGCTGAGC CAGCTGACCC ACGGCATCAC 46101 TGAGCTGGGC CCCTACACCC TGGACAGGCA CAGTCTCTAT GTCAATGGTT 46151 TCACCCATCA GAGCTCTATG ACGACCACCA GAACTCCTGA TACCTCCACA 46201 ATGCACCTGG CAACCTCGAG AACTCCAGCC TCCCTGTCTG GACCTACGAC 46251 CGCCAGCCCT CTCCTGGTGC TATTCACAAT TAACTTCACC ATCACTAACC 46301 TGCGGTATGA GGAGAACATG CATCACCCTG GCTCTAGAAA GTTTAACACC 46351 ACGGAGAGAG TCCTTCAGGG TCTGCTCAGG CCTGTGTTCA AGAACACCAG 46401 TGTTGGCCCT CTGTACTCTG GCTGCAGACT GACCACGCTC AGGCCCAAGA 46451 AGGATGGGGC AGCCACCAAA GTGGATGCCA TCTGCACCTA CCGCCCTGAT 46501 CCCAAAAGCC CTGGACTGGA CAGAGAGCAG CTATACTGGG AGCTGAGCCA 46551 GCTAACCCAC AGCATCACTG AGCTGGGCCC CTACACCCAG GACAGGGACA 46601 GTCTCTATGT CAATGGCTTC ACCCATCGGA GCTCTGTGCC AACCACCAGT 46651 ATTCCTGGGA CCTCTGCAGT GCACCTGGAA ACCTCTGGGA CTCCAGCCTC 46701 CCTCCCTGGC CACACAGCCC CTGGCCCTCT CCTGGTGCCA TTCACCCTCA 46751 ACTTCACTAT CACCAACCTG CAGTATGAGG AGGACATGCG TCACCCTGGT 46801 TCCAGGAAGT TCAACACCAC GGAGAGAGTC CTGCAGGGTC TGCTCAAGCC 46851 CTTGTTCAAG AGCACCAGTG TTGGCCCTCT GTACTCTGGC TGCAGACTGA 46901 CCTTGCTCAG GCCTGAAAAA CGTGGGGCAG CCACCGGCGT GGACACCATC 46951 TGCACTCACC GCCTTGACCC TCTAAACCCA GGACTGGACA GAGAGCAGCT 47001 ATACTGGGAG CTGAGCAAAC TGACCCGTGG CATCATCGAG CTGGGCCCCT 47051 ACCTCCTGGA CAGAGGCAGT CTCTATGTCA ATGGTTTCAC CCATCGGACC 47101 TCTGTGCCCA CCACCAGCAC TCCTGGGACC TCCACAGTGG ACCTTGGAAC 47151 CTCAGGGACT CCATTCTCCC TCCCAAGCCC CGCANCNNCT GNCCCTCTCC 47201 TGNTNCCNTT CACCNTCAAC TTNACCATCA CCAACCTGCA NTANGNGGAN 47251 NACATGCNNC NCCCNGGNTC CAGGAAGTTC AACACCACNG AGAGGGTCCT 47301 GCAGACTCTG CTTGGTCCTA TGTTCAAGAA CACCAGTGTT GGCCTTCTGT 47351 ACTCTGGCTG CAGACTGACC TTGCTCAGGT CCGAGAAGGA TGGAGCAGCC 47401 ACTGGAGTGG ATGCCATCTG CACCCACCGT CTTGACCCCA AAAGCCCTGG 47451 AGTGGACAGG GAGCAACTAT ACTGGGAGCT GAGCCAGCTG ACCAATGGCA 47501 TTAAAGAACT GGGCCCCTAC ACCCTGGACA GGAACAGTCT CTATGTCAAT 47551 GGGTTCACCC ATTGGATCCC TGTGCCCACC AGCAGCACTC CTGGGACCTC 47601 CACAGTGGAC CTTGGGTCAG GGACTCCATC CTCCCTCCCC AGCCCCACAA 47651 CTGCTGGCCC TCTCCTGGTG CCGTTCACCC TCAACTTCAC CATCACCAAC 47701 CTGAAGTACG AGGAGGACAT GCATTGCCCT GGCTCCAGGA AGTTCAACAC 47751 CACAGAGAGA GTCCTGCAGA GTCTGCTTGG TCCCATGTTC AAGAACACCA 47801 GTGTTGGCCC TCTGTACTCT GGCTGCAGAC TGACCTTGCT CAGGTCCGAG 47851 AAGGATGGAG CAGCCACTGG AGTGGATGCC ATCTGCACCC ACCGTCTTGA 47901 CCCCAAAAGC CCTGGAGTGG ACAGGGAGCA GCTATACTGG GAGCTGAGCC 47951 AGCTGACCAA TGGCATCAAA GAGCTGGGTC CCTACACCCT GGACAGAAAC 48001 AGTCTCTATG TCAATGGTTT CACCCATCAG ACCTCTGCGC CCAACACCAG 48051 CACTCCTGGG ACCTCCACAG TGGACCTTGG GACCTCAGGG ACTCCATCCT 48101 CCCTCCCCAG CCCTACANCN NCTGNCCCTC TCCTGNTNCC NTTCACCNTC 48151 AACTTNACCA TCACCAACCT GCANTANGNG GANNACATGC NNCNCCCNGG 48201 NTCCAGGAAG TTCAACACCA CNGAGNGNGT NCTGCAGGGT CTGCTNNNNC 48251 CCNTNTTCAA GAACNCCAGT GTNGGCCNTC TGTACTCTGG CTGCAGACTG 48301 ACCTNNCTCA GGNCNGAGAA GNATGGNGCA GCCACTGGAN TGGATGCCAT 48351 CTGCANCCAC CNNCNTNANC CCAAAAGNCC TGGACTGNAC AGNGAGCNGC 48401 TNTACTGGGA GCTNAGCCAN CTGACCAANN NCATCNNNGA GCTGGGNCCC 48451 TACACCCTGG ACAGGNACAG TCTCTATGTC AATGGTTTCA CCCATTGGAT 48501 CCCTGTGCCC ACCAGCAGCA CTCCTGGGAC CTCCACAGTG GACCTTGGGT 48551 CAGGGACTCC ATCCTCCCTC CCCAGCCCCA CAACTGCTGG CCCTCTCCTG 48601 GTGCCGTTCA CCCTCAACTT CACCATCACC AACCTGAAGT ACGAGGAGGA 48651 CATGCATTGC CCTGGCTCCA GGAAGTTCAA CACCACAGAG AGAGTCCTGC 48701 AGAGTCTGCT TGGTCCCATG TTCAAGAACA CCAGTGTTGG CCCTCTGTAC 48751 TCTGGCTGCA GACTGACCTC GCTCAGGTCC GAGAAGGATG GAGCAGCCAC 48801 TGGAGTGGAT GCCATCTGCA CCCACCGTGT TGACCCCAAA AGCCCTGGAG 48851 TGGACAGGGA GCAGCTATAC TGGGAGCTGA GCCAGCTGAC CAATGGCATC 48901 AAAGAGCTGG GTCCCTACAC CCTGGACAGA AACAGTCTCT ATGTCAATGG 48951 TTTCACCCAT CAGACCTCTG CGCCCAACAC CAGCACTCCT GGGACCTCCA 49001 CAGTGNACNT NGGNACCTCN GGGACTCCAT CCTCCNTCCC CNGCCNCACA 49051 TCTGCTGGCC CTCTCCTGGT GCCATTCACC CTCAACTTCA CCATCACCAA 49101 CCTGCAGTAC GAGGAGGACA TGCATCACCC AGGCTCCAGG AAGTTCAACA 49151 CCACGGAGCG GGTCCTGCAG GGTCTGCTTG GTCCCATGTT CAAGAACACC 49201 AGTGTCGGCC TTCTGTACTC TGGCTGCAGA CTGACCTTGC TCAGGCCTGA 49251 GAAGAATGGG GCAACCACTG GAATGGATGC CATCTGCACC CACCGTCTTG 49301 ACCCCAAAAG CCCTGGACTG NACAGNGAGC NGCTNTACTG GGAGCTNAGC 49351 CANCTGACCA ANNNCATCNN NGAGCTGGGN CCCTACACCC TGGACAGGNA 49401 CAGTCTCTAT GTCAATGGTT TCACCCATCN GANCTCTGNG CCCACCACCA 49451 GCACTCCTGG GACCTCCACA GTGNACNTNG GNACCTCNGG GACTCCATCC 49501 TCCNTCCCCN GCCNCACANC NNCTGNCCCT CTCCTGNTNC CNTTCACCNT 49551 CAACTTNACC ATCACCAACC TGCANTANGN GGANNACATG CNNCNCCCNG 49601 GNTCCAGGAA GTTCAACACC ACNGAGAGGG TTCTGCAGGG TCTGCTCAAA 49651 CCCTTGTTCA GGAATAGCAG TCTGGAATAC CTCTATTCAG GCTGCAGACT 49701 AGCCTCACTC AGGCCAGAGA AGGATAGCTC AGCCATGGCA GTGGATGCCA 49751 TCTGCACACA TCGCCCTGAC CCTGAAGACC TCGGACTGGA CAGAGAGCGA 49801 CTGTACTGGG AGCTGAGCAA TCTGACAAAT GGCATCCAGG AGCTGGGCCC 49851 CTACACCCTG GACCGGAACA GTCTCTATGT CAATGGTTTC ACCCATCGAA 49901 GCTCTATGCC CACCACCAGC ACTCCTGGGA CCTCCACAGT GGATGTGGGA 49951 ACCTCAGGGA CTCCATCCTC CAGCCCCAGC CCCACGACTG CTGGCCCTCT 50001 CCTGATACCA TTCACCCTCA ACTTCACCAT CACCAACCTG CAGTATGGGG 50051 AGGACATGGG TCACCCTGGC TCCAGGAAGT TCAACACCAC AGAGAGGGTC 50101 CTGCAGGGTC TGCTTGGTCC CATATTCAAG AACACCAGTG TTGGCCCTCT 50151 GTACTCTGGC TGCAGACTGA CCTCTCTCAG GTCTGAGAAG GATGGAGCAG 50201 CCACTGGAGT GGATGCCATC TGCATCCATC ATCTTGACCC CAAAAGCCCT 50251 GGACTCAACA GAGAGCGGCT GTACTGGGAG CTGAGCCAAC TGACCAATGG 50301 CATCAAAGAG CTGGGCCCCT ACACCCTGGA CAGGAACAGT CTCTATGTCA 50351 ATGGTTTCAC CCATCGGACC TCTGTGCCCA CCACCAGCAC TCCTGGGACC 50401 TCCACAGTGG ACCTTGGAAC CTCAGGGACT CCATTCTCCC TCCCAAGCCC 50451 CGCAACTGCT GGCCCTCTCC TGGTGCTGTT CACCCTCAAC TTCACCATCA 50501 CCAACCTGAA GTATGAGGAG GACATGCATC GCCCTGGCTC CAGGAAGTTC 50551 AACACCACTG AGAGGGTCCT GCAGACTCTG CTTGGTCCTA TGTTCAAGAA 50601 CACCAGTGTT GGCCTTCTGT ACTCTGGCTG CAGACTGACC TTGCTCAGGT 50651 CCGAGAAGGA TGGAGCAGCC ACTGGAGTGG ATGCCATCTG CACCCACCGT 50701 CTTGACCCCA AAAGCCCTGG ACTGNACAGN GAGCNGCTNT ACTGGGAGCT 50751 NAGCCANCTG ACCAANNNCA TCNNNGAGCT GGGNCCCTAC ACCCTGGACA 50801 GGNACAGTCT CTATGTCAAT GGTTTCACCC ATCNGANCTC TGNGCCCACC 50851 ACCAGCACTC CTGGGACCTC CACAGTGNAC NTNGGNACCT CNGGGACTCC 50901 ATCCTCCNTC CCCNGCCNCA CANCNNCTGN CCCTCTCCTG NTNCCNTTCA 50951 CCNTCAACTT NACCATCACC AACCTGCANT ANGNGGANNA CATGCNNCNC 51001 CCNGGNTCCA GGAAGTTCAA CACCACNGAG AGAGTCCTTC AGGGTCTGCT 51051 CAGGCCTGTG TTCAAGAACA CCAGTGTTGG CCCTCTGTAC TCTGGCTGCA 51101 GACTGACCTT GCTCAGGCCC AAGAAGGATG GGGCAGCCAC CAAAGTGGAT 51151 GCCATCTGCA CCTACCGCCC TGATCCCAAA AGCCCTGGAC TGGACAGAGA 51201 GCAGCTATAC TGGGAGCTGA GCCAGCTAAC CCACAGCATC ACTGAGCTGG 51251 GCCCCTACAC CCAGGACAGG GACAGTCTCT ATGTCAATGG CTTCACCCAT 51301 CGGAGCTCTG TGCCAACCAC CAGTATTCCT GGGACCTCTG CAGTGCACCT 51351 GGAAACCACT GGGACTCCAT CCTCCTTCCC CGGCCACACA GAGCCTGGCC 51401 CTCTCCTGAT ACCATTCACT TTCAACTTTA CCATCACCAA CCTGCGTTAT 51451 GAGGAAAACA TGCAACACCC TGGTTCCAGG AAGTTCAACA CCACGGAGAG 51501 GGTTCTGCAG GGTCTGCTCA CGCCCTTGTT CAAGAACACC AGTGTTGGCC 51551 CTCTGTACTC TGGCTGCAGA CTGACCTTGC TCAGACCTGA GAAGCAGGAG 51601 GCAGCCACTG GAGTGGACAC CATCTGTACC CACCGCGTTG ATCCCATCGG 51651 ACCTGGACTG GACAGAGAGC GGCTATACTG GGAGCTGAGC CAGCTGACCA 51701 ACAGCATCAC AGAGCTGGGA CCCTACACCC TGGATAGGGA CAGTCTCTAT 51751 GTCGATGGCT TCAACCCTTG GAGCTCTGTG CCAACCACCA GCACTCCTGG 51801 GACCTCCACA GTGCACCTGG CAACCTCTGG GACTCCATCC CCCCTGCCTG 51851 GCCACACAGC CCCTGTCCCT CTCTTGATAC CATTCACCCT CAACTTTACC 51901 ATCACCGACC TGCATTATGA AGAAAACATG CAACACCCTG GTTCCAGGAA 51951 GTTCAACACC ACGGAGAGGG TTCTGCAGGG TCTGCTCAAG CCCTTGTTCA 52001 AGAGCACCAG CGTTGGCCCT CTGTACTCTG GCTGCAGACT GACCTTGCTC 52051 AGACCTGAGA AACATGGGGC AGCCACTGGA GTGGACGCCA TCTGCACCCT 52101 CCGCCTTGAT CCCACTGGTC CTGGACTGGA CAGAGAGCGG CTATACTGGG 52151 AGCTGAGCCA GCTGACCAAC AGCATCACAG AGCTGGGACC CTACACCCTG 52201 GATAGGGACA GTCTCTATGT CAATGGCTTC AACCCTTGGA GCTCTGTGCC 52251 AACCACCAGC ACTCCTGGGA CCTCCACAGT GCACCTGGCA ACCTCTGGGA 52301 CTCCATCCTC CCTGCCTGGC CACACAACTG CTGGCCCTCT CCTGGTGCCG 52351 TTCACCCTCA ACTTCACCAT CACCAACCTG AAGTACGAGG AGGACATGCA 52401 TTGCCCTGGC TCCAGGAAGT TCAACACCAC AGAGAGAGTC CTGCAGAGTC 52451 TGCATGGTCC CATGTTCAAG AACACCAGTG TTGGCCCTCT GTACTCTGGC 52501 TGCAGACTGA CCTTGCTCAG GTCCGAGAAG GATGGAGCAG CCACTGGAGT 52551 GGATGCCATC TGCACCCACC GTCTTGACCC CAAAAGCCCT GGACTGNACA 52601 GNGAGCNGCT NTACTGGGAG CTNAGCCANC TGACCAANNN CATCNNNGAG 52651 CTGGGNCCCT ACACCCTGGA CAGGNACAGT CTCTATGTCA ATGGTTTCAC 52701 CCATCNGANC TCTGNGCCCA CCACCAGCAC TCCTGGGACC TCCACAGTGN 52751 ACNTNGGNAC CTCNGGGACT CCATCCTCCN TCCCCNGCCN CACANCNNCT 52801 GNCCCTCTCC TGNTNCCNTT CACCNTCAAC TTNACCATCA CCAACCTGCA 52851 NTANGNGGAN NACATGCNNC NCCCNGGNTC CAGGAAGTTC AACACCACNG 52901 AGNGNGTNCT GCAGGGTCTG CTNNNNCCCN TNTTCAAGAA CNCCAGTGTN 52951 GGCCNTCTGT ACTCTGGCTG CAGACTGACC TNNCTCAGGN CNGAGAAGNA 53001 TGGNGCAGCC ACTGGANTGG ATGCCATCTG CANCCACCNN CNTNANCCCA 53051 AAAGNCCTGG ACTGNACAGN GAGCNGCTNT ACTGGGAGCT NAGCCANCTG 53101 ACCAACAGCA TCACAGAGCT GGGACCCTAC ACCCTGGATA GGGACAGTCT 53151 CTATGTCAAT GGTTTCACCC ATCGAAGCTC TATGCCCACC ACCAGTATTC 53201 CTGGGACCTC TGCAGTGCAC CTGGAAACCT CTGGGACTCC AGCCTCCCTC 53251 CCTGGCCACA CAGCCCCTGG CCCTCTCCTG GTGCCATTCA CCCTCAACTT 53301 CACTATCACC AACCTGCAGT ATGAGGAGGA CATGCGTCAC CCTGGTTCCA 53351 GGAAGTTCAA CACCACGGAG AGAGTCCTGC AGGGTCTGCT CAAGCCCTTG 53401 TTCAAGAGCA CCAGTGTTGG CCCTCTGTAC TCTGGCTGCA GACTGACCTT 53451 GCTCAGGCCT GAAAAACGTG GGGCAGCCAC CGGCGTGGAC ACCATCTGCA 53501 CTCACCGCCT TGACCCTCTA AACCCTGGAC TGNACAGNGA GCNGCTNTAC 53551 TGGGAGCTNA GCCANCTGAC CAANNNCATC NNNGAGCTGG GNCCCTACAC 53601 CCTGGACAGG NACAGTCTCT ATGTCAATGG TTTCACCCAT CNGANCTCTG 53651 NGCCCACCAC CAGCACTCCT GGGACCTCCA CAGTGNACNT NGGNACCTCN 53701 GGGACTCCAT CCTCCNTCCC CNGCCNCACA NCNNCTGNCC CTCTCCTGNT 53751 NCCNTTCACC NTCAACTTNA CCATCACCAA CCTGCANTAN GNGGANNACA 53801 TGCNNCNCCC NGGNTCCAGG AAGTTCAACA CCACNGAGNG NGTNCTGCAG 53851 GGTCTGCTNN NNCCCNTNTT CAAGAACNCC AGTGTNGGCC NTCTGTACTC 53901 TGGCTGCAGA CTGACCTNNC TCAGGNCNGA GAAGNATGGN GCAGCCACTG 53951 GANTGGATGC CATCTGCANC CACCNNCNTN ANCCCAAAAG NCCTGGACTG 54001 NACAGNGAGC NGCTNTACTG GGAGCTNAGC CANCTGACCA ANNNCATCNN 54051 NGAGCTGGGN CCCTACACCC TGGACAGGNA CAGTCTCTAT GTCAATGGTT 54101 TTCACCCTCG GAGCTCTGTG CCAACCACCA GCACTCCTGG GACCTCCACA 54151 GTGCACCTGG CAACCTCTGG GACTCCATCC TCCCTGCCTG GCCACACAGC 54201 CCCTGTCCCT CTCTTGATAC CATTCACCCT CAACTTTACC ATCACCAACC 54251 TGCATTATGA AGAAAACATG CAACACCCTG GTTCCAGGAA GTTCAACACC 54301 ACGGAGCGGG TCCTGCAGGG TCTGCTTGGT CCCATGTTCA AGAACACAAG 54351 TGTCGGCCTT CTGTACTCTG GCTGCAGACT GACCTTGCTC AGGCCTGAGA 54401 AGAATGGGGC AGCCACTGGA ATGGATGCCA TCTGCAGCCA CCGTCTTGAC 54451 CCCAAAAGCC CTGGACTGNA CAGNGAGCNG CTNTACTGGG AGCTNAGCCA 54501 NCTGACCAAN NNCATCNNNG AGCTGGGNCC CTACACCCTG GACAGGNACA 54551 GTCTCTATGT CAATGGTTTC ACCCATCNGA NCTCTGNGCC CACCACCAGC 54601 ACTCCTGGGA CCTCCACAGT GNACNTNGGN ACCTCNGGGA CTCCATCCTC 54651 CNTCCCCNGC CNCACANCNN CTGNCCCTCT CCTGNTNCCN TTCACCNTCA 54701 ACTTNACCAT CACCAACCTG CANTANGNGG ANNACATGCN NCNCCCNGGN 54751 TCCAGGAAGT TCAACACCAC NGAGNGNGTN CTGCAGGGTC TGCTNNNNCC 54801 CNTNTTCAAG AACNCCAGTG TNGGCCNTCT GTACTCTGGC TGCAGACTGA 54851 CCTNNCTCAG GNCNGAGAAG NATGGNGCAG CCACTGGANT GGATGCCATC 54901 TGCANCCACC NNCNTNANCC CAAAAGNCCT GGACTGNACA GNGAGCNGCT 54951 NTACTGGGAG CTNAGCCANC TGACCAANNN CATCNNNGAG CTGGGNCCCT 55001 ACACCCTGGA CAGGNACAGT CTCTATGTCA ATGGTTTCAC CCATCAGAAC 55051 TCTGTGCCCA CCACCAGTAC TCCTGGGACC TCCACAGTGT ACTGGGCAAC 55101 CACTGGGACT CCATCCTCCT TCCCCGGCCA CACAGAGCCT GGCCCTCTCC 55151 TGATACCATT CACTTTCAAC TTTACCATCA CCAACCTGCA TTATGAGGAA 55201 AACATGCAAC ACCCTGGTTC CAGGAAGTTC AACACCACGG AGAGGGTTCT 55251 GCAGGGTCTG CTCACGCCCT TGTTCAAGAA CACCAGTGTT GGCCCTCTGT 55301 ACTCTGGCTG CAGACTGACC TTGCTCAGAC CTGAGAAGCA GGAGGCAGCC 55351 ACTGGAGTGG ACACCATCTG TACCCACCGC GTTGATCCCA TCGGACCTGG 55401 ACTGNACAGN GAGCNGCTNT ACTGGGAGCT NAGCCANCTG ACCAANNNCA 55451 TCNNNGAGCT GGGNCCCTAC ACCCTGGACA GGNACAGTCT CTATGTCAAT 55501 GGTTTCACCC ATCNGANCTC TGNGCCCACC ACCAGCACTC CTGGGACCTC 55551 CACAGTGNAC NTNGGNACCT CNGGGACTCC ATCCTCCNTC CCCNGCCNCA 55601 CANCNNCTGN CCCTCTCCTG NTNCCNTTCA CCNTCAACTT NACCATCACC 55651 AACCTGCANT ANGNGGANNA CATGCNNCNC CCNGGNTCCA GGAAGTTCAA 55701 CACCACNGAG NGNGTNCTGC AGGGTCTGCT NNNNCCCNTN TTCAAGAACN 55751 CCAGTGTNGG CCNTCTGTAC TCTGGCTGCA GACTGACCTN NCTCAGGNCN 55801 GAGAAGNATG GNGCAGCCAC TGGANTGGAT GCCATCTGCA NCCACCNNCN 55851 TNANCCCAAA AGNCCTGGAC TGNACAGNGA GCNGCTNTAC TGGGAGCTNA 55901 GCCANCTGAC CAANNNCATC NNNGAGCTGG GNCCCTACAC CCTGGACAGG 55951 NACAGTCTCT ATGTCAATGG TTTCACCCAT CGGAGCTCTG TGCCAACCAC 56001 CAGCAGTCCT GGGACCTCCA CAGTGCACCT GGCAACCTCT GGGACTCCAT 56051 CCTCCCTGCC TGGCCACACA GCCCCTGTCC CTCTCTTGAT ACCATTCACC 56101 CTCAACTTTA CCATCACCAA CCTGCATTAT GAAGAAAACA TGCAACACCC 56151 TGGTTCCAGG AAGTTCAACA CCACGGAGAG GGTTCTGCAG GGTCTGCTCA 56201 AGCCCTTGTT CAAGAGCACC AGTGTTGGCC CTCTGTACTC TGGCTGCAGA 56251 CTGACCTTGC TCAGACCTGA GAAACATGGG GCAGCCACTG GAGTGGACGC 56301 CATCTGCACC CTCCGCCTTG ATCCCACTGG TCCTGGACTG NACAGNGAGC 56351 NGCTNTACTG GGAGCTNAGC CANCTGACCA ANNNCATCNN NGAGCTGGGN 56401 CCCTACACCC TGGACAGGNA CAGTCTCTAT GTCAATGGTT TCACCCATCN 56451 GANCTCTGNG CCCACCACCA GCACTCCTGG GACCTCCACA GTGNACNTNG 56501 GNACCTCNGG GACTCCATCC TCCNTCCCCN GCCNCACANC NNCTGNCCCT 56551 CTCCTGNTNC CNTTCACCNT CAACTTNACC ATCACCAACC TGCANTANGN 56601 GGANNACATG CNNCNCCCNG GNTCCAGGAA GTTCAACACC ACNGAGNGNG 56651 TNCTGCAGGG TCTGCTNNNN CCCNTNTTCA AGAACNCCAG TGTNGGCCNT 56701 CTGTACTCTG GCTGCAGACT GACCTNNCTC AGGNCNGAGA AGNATGGNGC 56751 AGCCACTGGA NTGGATGCCA TCTGCANCCA CCNNCNTNAN CCCAAAAGNC 56801 CTGGACTGNA CAGNGAGCNG CTNTACTGGG AGCTNAGCCA NCTGACCAAN 56851 NNCATCNNNG AGCTGGGNCC CTACACCCTG GACAGGNACA GTCTCTATGT 56901 CAATGGTTTC ACCCATCGGA CCTCTGTGCC CACCACCAGC ACTCCTGGGA 56951 CCTCCACAGT GCACCTGGCA ACCTCTGGGA CTCCATCCTC CCTGCCTGGC 57001 CACACAGCCC CTGTCCCTCT CTTGATACCA TTCACCCTCA ACTTTACCAT 57051 CACCAACCTG CAGTATGAGG AGGACATGCA TCGCCCTGGA TCTAGGAAGT 57101 TCAACACCAC AGAGAGGGTC CTGCAGGGTC TGCTTAGTCC CATTTTCAAG 57151 AACTCCAGTG TTGGCCCTCT GTACTCTGGC TGCAGACTGA CCTCTCTCAG 57201 GCCCGAGAAG GATGGGGCAG CAACTGGAAT GGATGCTGTC TGCCTCTACC 57251 ACCCTAATCC CAAAAGACCT GGGCTGGACA GAGAGCAGCT GTACTGCGAG 57301 CTAAGCCAGC TGACCCACAA CATCACTGAG CTGGGCCCCT ACAGCCTGGA 57351 CAGGGACAGT CTCTATGTCA ATGGTTTCAC CCATCAGAAC TCTGTGCCCA 57401 CCACCAGTAC TCCTGGGACC TCCACAGTGT ACTGGGCAAC CACTGGGACT 57451 CCATCCTCCT TCCCCGGCCA CACANCNNCT GNCCCTCTCC TGNTNCCNTT 57501 CACCNTCAAC TTNACCATCA CCAACCTGCA NTANGNGGAN NACATGCNNC 57551 NCCCNGGNTC CAGGAAGTTC AACACCACNG AGNGNGTNCT GCAGGGTCTG 57601 CTNNNNCCCN TNTTCAAGAA CNCCAGTGTN GGCCNTCTGT ACTCTGGCTG 57651 CAGACTGACC TNNCTCAGGN CNGAGAAGNA TGGNGCAGCC ACTGGANTGG 57701 ATGCCATCTG CANCCACCNN CNTNANCCCA AAAGNCCTGG ACTGNACAGN 57751 GAGCNGCTNT ACTGGGAGCT NAGCCANCTG ACCAANNNCA TCNNNGAGCT 57801 GGGNCCCTAC ACCCTGGACA GGNACAGTCT CTATGTCAAT GGTTTCACCC 57851 ATTGGAGCTC TGGGCTCACC ACCAGCACTC CTTGGACTTC CACAGTTGAC 57901 CTTGGAACCT CAGGGACTCC ATCCCCCGTC CCCAGCCCCA CAACTGCTGG 57951 CCCTCTCCTG GTGCCATTCA CCCTAAACTT CACCATCACC AACCTGCAGT 58001 ATGAGGAGGA CATGCATCGC CCTGGATCTA GGAAGTTCAA CGCCACAGAG 58051 AGGGTCCTGC AGGGTCTGCT TAGTCCCATA TTCAAGAACA CCAGTGTTGG 58101 CCCTCTGTAC TCTGGCTGCA GACTGACCTT GCTCAGACCT GAGAAGCAGG 58151 AGGCAGCCAC TGGAGTGGAC ACCATCTGTA CCCACCGCGT TGATCCCATC 58201 GGACCTGGAC TGNACAGNGA GCUGCTNTAC TGGGAGCTNA GCCANCTGAC 58251 CAANNNCATC NNNGAGCTGG GNCCCTACAC CCTGGACAGG NACAGTCTCT 58301 ATGTCAATGG TTTCACCCAT CNGANCTCTG NGCCCACCAC CAGCACTCCT 58351 GGGACCTCCA CAGTGNACNT NGGNACCTCN GGGACTCCAT CCTCCNTCCC 58401 CNGCCNCACA NCNNCTGNCC CTCTCCTGNT NCCNTTCACC NTCAACTTNA 58451 CCATCACCAA CCTGCANTAN GNGGANNACA TGCNNCNCCC NGGNTCCAGG 58501 AAGTTCAACA CCACNGAGNG NGTNCTGCAG GGTCTGCTNN NNCCCNTNTT 58551 CAAGAACNCC AGTGTNGGCC NTCTGTACTC TGGCTGCAGA CTGACCTNNC 58601 TCAGGNCNGA GAAGNATGGN GCAGCCACTG GANTGGATGC CATCTGCANC 58651 CACCNNCNTN ANCCCAAAAG NCCTGGACTG NACAGNGAGC NGCTNTACTG 58701 GGAGCTNAGC CANCTGACCA ANNNCATCNN NGAGCTGGGN CCCTACACCC 58751 TGGACAGGNA CAGTCTCTAT GTCAATGGTT TCACCCATCG GAGCTTTGGG 58801 CTCACCACCA GCACTCCTTG GACTTCCACA GTTGACCTTG GAACCTCAGG 58851 GACTCCATCC CCCGTCCCCA GCCCCACAAC TGCTGGCCCT CTCCTGGTGC 58901 CATTCACCCT AAACTTCACC ATCACCAACC TGCAGTATGA GGAGGACATG 58951 CATCGCCCTG GCTCCAGGAA GTTCAACACC ACGGAGAGGG TCCTTCAGGG 59001 TCTGCTTACG CCCTTGTTCA GGAACACCAG TGTCAGCTCT CTGTACTCTG 59051 GTTGCAGACT GACCTTGCTC AGGCCTGAGA AGGATGGGGC AGCCACCAGA 59101 GTGGATGCTG TCTGCACCCA TCGTCCTGAC CCCAAAAGCC CTGGACTGNA 59151 CAGNGAGCNG CTNTACTGGG AGCTNAGCCA NCTGACCAAN NNCATCNNNG 59201 AGCTGGGNCC CTACACCCTG GACAGGNACA GTCTCTATGT CAATGGTTTC 59251 ACCCATCNGA NCTCTGNGCC CACCACCAGC ACTCCTGGGA CCTCCACAGT 59301 GNACNTNGGN ACCTCNGGGA CTCCATCCTC CNTCCCCNGC CNCACANCNN 59351 CTGNCCCTCT CCTGNTNCCN TTCACCNTCA ACTTNACCAT CACCAACCTG 59401 CANTANGNGG ANNACATGCN NCNCCCNGGN TCCAGGAAGT TCAACACCAC 59451 NGAGNGNGTN CTGCAGGGTC TGCTNNNNCC CNTNTTCAAG AACNCCAGTG 59501 TNGGCCNTCT GTACTCTGGC TGCAGACTGA CCTNNCTCAG GNCNGAGAAG 59551 NATGGNGCAG CCACTGGANT GGATGCCATC TGCANCCACC NNCNTNANCC 59601 CAAAAGNCCT GGACTGNACA GNGAGCNGCT NTACTGGGAG CTNAGCCANC 59651 TGACCAANNN CATCNNNGAG CTGGGNCCCT ACACCCTGGA CAGGNACAGT 59701 CTCTATGTCA ATGGTTTCAC CCATTGGATC CCTGTGCCCA CCAGCAGCAC 59751 TCCTGGGACC TCCACAGTGG ACCTTGGGTC AGGGACTCCA TCCTCCCTCC 59801 CCAGCCCCAC AACTGCTGGC CCTCTCCTGG TACCATTCAC CCTCAACTTC 59851 ACCATCACCA ACCTGCAGTA TGGGGAGGAC ATGGGTCACC CTGGCTCCAG 59901 GAAGTTCAAC ACCACAGAGA GGGTCCTGCA GGGTCTGCTT GGTCCCATAT 59951 TCAAGAACAC CAGTGTTGGC CCTCTGTACT CTGGCTGCAG ACTGACCTCT 60001 CTCAGGTCCG AGAAGGATGG AGCAGCCACT GGAGTGGATG CCATCTGCAT 60051 CCATCATCTT GACCCCAAAA GCCCTGGACT GNACAGNGAG CNGCTNTACT 60101 GGGAGCTNAG CCANCTGACC AANNNCATCN NNGAGCTGGG NCCCTACACC 60151 CTGGACAGGN ACAGTCTCTA TGTCAATGGT TTCACCCATC NGANCTCTGN 60201 GCCCACCACC AGCACTCCTG GGACCTCCAC AGTGNACNTN GGNACCTCNG 60251 GGACTCCATC CTCCNTCCCC NGCCNCACAN CNNCTGNCCC TCTCCTGNTN 60301 CCNTTCACCN TCAACTTNAC CATCACCAAC CTGCANTANG NGGANNACAT 60351 GCNNCNCCCN GGNTCCAGGA AGTTCAACAC CACNGAGNGN GTNCTGCAGG 60401 GTCTGCTNNN NCCCNTNTTC AAGAACNCCA GTGTNGGCCN TCTGTACTCT 60451 GGCTGCAGAC TGACCTNNCT CAGGNCNGAG AAGNATGGNG CAGCCACTGG 60501 ANTGGATGCC ATCTGCANCC ACCNNCNTNA NCCCAAAAGN CCTGGACTGN 60551 ACAGNGAGCN GCTNTACTGG GAGCTNAGCC ANCTGACCAA NNNCATCNNN 60601 GAGCTGGGNC CCTACACCCT GGACAGGNAC AGTCTCTATG TCAATGGTTT 60651 CACCCATCAG ACCTTTGCGC CCAACACCAG CACTCCTGGG ACCTCCACAG 60701 TGGACCTTGG GACCTCAGGG ACTCCATCCT CCCTCCCCAG CCCTACATCT 60751 GCTGGCCCTC TCCTGGTGCC ATTCACCCTC AACTTCACCA TCACCAACCT 60801 GCAGTACGAG GAGGACATGC ATCACCCAGG CTCCAGGAAG TTCAACACCA 60851 CGGAGCGGGT CCTGCAGGGT CTGCTTGGTC CCATGTTCAA GAACACCAGT 60901 GTCGGCCTTC TGTACTCTGG CTGCAGACTG ACCTTGCTCA GGCCTGAGAA 60951 GAATGGGGCA GCCACCAGAG TGGATGCTGT CTGCACCCAT CGTCCTGACC 61001 CCAAAAGCCC TGGACTGNAC AGNGAGCNGC TNTACTGGGA GCTNAGCCAN 61051 CTGACCAANN NCATCNNNGA GCTGGGNCCC TACACCCTGG ACAGGNACAG 61101 TCTCTATGTC AATGGTTTCA CCCATCNGAN CTCTGNGCCC ACCACCAGCA 61151 CTCCTGGGAC CTCCACAGTG NACNTNGGNA CCTCNGGGAC TCCATCCTCC 61201 NTCCCCNGCC NCACAGCCCC TGTCCCTCTC TTGATACCAT TCACCCTCAA 61251 CTTTACCATC ACCAACCTGC ATTATGAAGA AAACATGCAA CACCCTGGTT 61301 CCAGGAAGTT CAACACCACG GAGAGGGTTC TGCAGGGTCT GCTCAAGCCC 61351 TTGTTCAAGA GCACCAGCGT TGGCCCTCTG TACTCTGGCT GCAGACTGAC 61401 CTTGCTCAGA CCTGAGAAAC ATGGGGCAGC CACTGGAGTG GACGCCATCT 61451 GCACCCTCCG CCTTGATCCC ACTGGTCCTG GACTGGACAG AGAGCGGCTA 61501 TACTGGGAGC TGAGCCAGCT GACCAACAGC GTTACAGAGC TGGGCCCCTA 61551 CACCCTGGAC AGGGACAGTC TCTATGTCAA TGGCTTCACC CAGCGGAGCT 61601 CTGTGCCAAC CACCAGTATT CCTGGGACCT CTGCAGTGCA CCTGGAAACC 61651 TCTGGGACTC CAGCCTCCCT CCCTGGCCAC ACAGCCCCTG GCCCTCTCCT 61701 GGTGCCATTC ACCCTCAACT TCACTATCAC CAACCTGCAG TATGAGGTGG 61751 ACATGCGTCA CCCTGGTTCC AGGAAGTTCA ACACCACGGA GAGAGTCCTG 61801 CAGGGTCTGC TCAAGCCCTT GTTCAAGAGC ACCAGTGTTG GCCCTCTGTA 61851 CTCTGGCTGC AGACTGACCT TGCTCAGGCC TGAAAAACGT GGGGCAGCCA 61901 CCGGCGTGGA CACCATCTGC ACTCACCGCC TTGACCCTCT AAACCCTGGA 61951 CTGGACAGAG AGCAGCTATA CTGGGAGCTG AGCAAACTGA CCCGTGGCAT 62001 CATCGAGCTG GGCCCCTACC TCCTGGACAG AGGCAGTCTC TATGTCAATG 62051 GTTTCACCCA TCGGAACTTT GTGCCCATCA CCAGCACTCC TGGGACCTCC 62101 ACAGTACACC TAGGAACCTC TGAAACTCCA TCCTCCCTAC CTAGACCCAT 62151 AGTGCCTGGC CCTCTCCTGG TGCCATTCAC CCTCAACTTC ACCATCACCA 62201 ACTTGCAGTA TGAGGAGGCC ATGCGACACC CTGGCTCCAG GAAGTTCAAT 62251 ACCACGGAGA GGGTCCTACA GGGTCTGCTC AGGCCCTTGT TCAAGAATAC 62301 CAGTATCGGC CCTCTGTACT CCAGCTGCAG ACTGACCTTG CTCAGGCCAG 62351 AGAAGGACAA GGCAGCCACC AGAGTGGATG CCATCTGTAC CCACCACCCT 62401 GACCCTCAAA GCCCTGGACT GAACAGAGAG CAGCTGTACT GGGAGCTGAG 62451 CCAGCTGACC CACGGCATCA CTGAGCTGGG CCCCTACACC CTGGACAGGG 62501 ACAGTCTCTA TGTCGATGGT TTCACTCATT GGAGCCCCAT ACCGACCACC 62551 AGCACTCCTG GGACCTCCAT AGTGAACCTG GGAACCTCTG GGATCCCACC 62601 TTCCCTCCCT GAAACTACAN CNNCTGNCCC TCTCCTGNTN CCNTTCACCN 62651 TCAACTTNAC CATCACCAAC CTGCANTANG NGGANNACAT GCNNCNCCCN 62701 GGNTCCAGGA AGTTCAACAC CACNGAGAGG GTTCTGCAGG GTCTGCTCAA 62751 GCCCTTGTTC AAGAGCACCA GTGTTGGCCC TCTGTATTCT GGCTGCAGAC 62801 TGACCTTGCT CAGGCCTGAG AAGGACGGAG TAGCCACCAG AGTGGACGCC 62851 ATCTGCACCC ACCGCCCTGA CCCCAAAATC CCTGGGCTAG ACAGACAGCA 62901 GCTATACTGG GAGCTGAGCC AGCTGACCCA CAGCATCACT GAGCTGGGAC 62951 CCTACACCCT GGATAGGGAC AGTCTCTATG TCAATGGTTT CACCCAGCGG 63001 AGCTCTGTGC CCACCACCAG CACTCCTGGG ACTTTCACAG TACAGCCGGA 63051 AACCTCTGAG ACTCCATCAT CCCTCCCTGG CCCCACAGCC ACTGGCCCTG 63101 TCCTGCTGCC ATTCACCCTC AATTTTACCA TCACTAACCT GCAGTATGAG 63151 GAGGACATGC ATCGCCCTGG CTCCAGGAAG TTCAACACCA CGGAGAGGGT 63201 CCTTCAGGGT CTGCTTATGC CCTTGTTCAA GAACACCAGT GTCAGCTCTC 63251 TGTACTCTGG TTGCAGACTG ACCTTGCTCA GGCCTGAGAA GGATGGGGCA 63301 GCCACCAGAG TGGATGCTGT CTGCACCCAT CGTCCTGACC CCAAAAGCCC 63351 TGGACTGGAC AGAGAGCGGC TGTACTGGAA GCTGAGCCAG CTGACCCACG 63401 GCATCACTGA GCTGGGCCCC TACACCCTGG ACAGGCACAG TCTCTATGTC 63451 AATGGTTTCA CCCATCAGAG CTCTATGACG ACCACCAGAA CTCCTGATAC 63501 CTCCACAATG CACCTGGCAA CCTCGAGAAC TCCAGCCTCC CTGTCTGGAC 63551 CTACGACCGC CAGCCCTCTC CTGGTGCTAT TCACAATTAA CTTCACCATC 63601 ACTAACCTGC GGTATGAGGA GAACATGCAT CACCCTGGCT CTAGAAAGTT 63651 TAACACCACG GAGAGAGTCC TTCAGGGTCT GCTCAGGCCT GTGTTCAAGA 63701 ACACCAGTGT TGGCCCTCTG TACTCTGGCT GCAGACTGAC CTTGCTCAGG 63751 CCCAAGAAGG ATGGGGCAGC CACCAAAGTG GATGCCATCT GCACCTACCG 63801 CCCTGATCCC AAAAGCCCTG GACTGGACAG AGAGCAGCTA TACTGGGAGC 63851 TGAGCCAGCT AACCCACAGC ATCACTGAGC TGGGCCCCTA CACCCTGGAC 63901 AGGGACAGTC TCTATGTCAA TGGTTTCACA CAGCGGAGCT CTGTGCCCAC 63951 CACTAGCATT CCTGGGACCC CCACAGTGGA CCTGGGAACA TCTGGGACTC 64001 CAGTTTCTAA ACCTGGTCCC TCGGCTGCCA GCCCTCTCCT GGTGCTATTC 64051 ACTCTCAACT TCACCATCAC CAACCTGCGG TATGAGGAGA ACATGCAGCA 64101 CCCTGGCTCC AGGAAGTTCA ACACCACGGA GAGGGTCCTT CAGGGCCTGC 64151 TCAGGTCCCT GTTCAAGAGC ACCAGTGTTG GCCCTCTGTA CTCTGGCTGC 64201 AGACTGACTT TGCTCAGGCC TGAAAAGGAT GGGACAGCCA CTGGAGTGGA 64251 TGCCATCTGC ACCCACCACC CTGACCCCAA AAGCCCTAGG CTGGACAGAG 64301 AGCAGCTGTA TTGGGAGCTG AGCCAGCTGA CCCACAATAT CACTGAGCTG 64351 GGCCACTATG CCCTGGACAA CGACAGCCTC TTTGTCAATG GTTTCACTCA 64401 TCGGAGCTCT GTGTCCACCA CCAGCACTCC TGGGACCCCC ACAGTGTATC 64451 TGGGAGCATC TAAGACTCCA GCCTCGATAT TTGGCCCTTC AGCTGCCAGC 64501 CATCTCCTGA TACTATTCAC CCTCAACTTC ACCATCACTA ACCTGCGGTA 64551 TGAGGAGAAC ATGTGGCCTG GCTCCAGGAA GTTCAACACT ACAGAGAGGG 64601 TCCTTCAGGG CCTGCTAAGG CCCTTGTTCA AGAACACCAG TGTTGGCCCT 64651 CTGTACTCTG GCTCCAGGCT GACCTTGCTC AGGCCAGAGA AAGATGGGGA 64701 AGCCACCGGA GTGGATGCCA TCTGCACCCA CCGCCCTGAC CCCACAGGCC 64751 CTGGGCTGGA CAGAGAGCAG CTGTATTTGG AGCTGAGCCA GCTGACCCAC 64801 AGCATCACTG AGCTGGGCCC CTACACACTG GACAGGGACA GTCTCTATGT 64851 CAATGGTTTC ACCCATCGGA GCTCTGTACC CACCACCAGC ACCGGGGTGG 64901 TCAGCGAGGA GCCATTCACA CTGAACTTCA CCATCAACAA CCTGCGCTAC 64951 ATGGCGGACA TGGGCCAACC CGGCTCCCTC AAGTTCAACA TCACAGACAA 65001 CGTCATGAAG CACCTGCTCA GTCCTTTGTT CCAGAGGAGC AGCCTGGGTG 65051 CACGGTACAC AGGCTGCAGG GTCATCGCAC TAAGGTCTGT GAAGAACGGT 65101 GCTGAGACAC GGGTGGACCT CCTCTGCACC TACCTGCAGC CCCTCAGCGG 65151 CCCAGGTCTG CCTATCAAGC AGGTGTTCCA TGAGCTGAGC CAGCAGACCC 65201 ATGGCATCAC CCGGCTGGGC CCCTACTCTC TGGACAAAGA CAGCCTCTAC 65251 CTTAACGGTT ACAATGAACC TGGTCTAGAT GAGCCTCCTA CAACTCCCAA 65301 GCCAGCCACC ACATTCCTGC CTCCTCTGTC AGAAGCCACA ACAGCCATGG 65351 GGTACCACCT GAAGACCCTC ACACTCAACT TCACCATCTC CAATCTCCAG 65401 TATTCACCAG ATATGGGCAA GGGCTCAGCT ACATTCAACT CCACCGAGGG 65451 GGTCCTTCAG CACCTGCTCA GACCCTTGTT CCAGAAGAGC AGCATGGGCC 65501 CCTTCTACTT GGGTTGCCAA CTGATCTCCC TCAGGCCTGA GAAGGATGGG 65551 GCAGCCACTG GTGTGGACAC CACCTGCACC TACCACCCTG ACCCTGTGGG 65601 CCCCGGGCTG GACATACAGC AGCTTTACTG GGAGCTGAGT CAGCTGACCC 65651 ATGGTGTCAC CCAACTGGGC TTCTATGTCC TGGACAGGGA TAGCCTCTTC 65701 ATCAATGGCT ATGCACCCCA GAATTTATCA ATCCGGGGCG AGTACCAGAT 65751 AAATTTCCAC ATTGTCAACT GGAACCTCAG TAATCCAGAC CCCACATCCT 65801 CAGAGTACAT CACCCTGCTG AGGGACATCC AGGACAAGGT CACCACACTC 65851 TACAAAGGCA GTCAACTACA TGACACATTC CGCTTCTGCC TGGTCACCAA 65901 CTTGACGATG GACTCCGTGT TGGTCACTGT CAAGGCATTG TTCTCCTCCA 65951 ATTTGGACCC CAGCCTGGTG GAGCAAGTCT TTCTAGATAA GACCCTGAAT 66001 GCCTCATTCC ATTGGCTGGG CTCCACCTAC CAGTTGGTGG ACATCCATGT 66051 GACAGAAATG GAGTCATCAG TTTATCAACC AACAAGCAGC TCCAGCACCC 66101 AGCACTTCTA CCTGAATTTC ACCATCACCA ACCTACCATA TTCCCAGGAC 66151 AAAGCCCAGC CAGGCACCAC CAATTACCAG AGGAACAAAA GGAATATTGA 66201 GGATGCGCTC AACCAACTCT TCCGAAACAG CAGCATCAAG AGTTATTTTT 66251 CTGACTGTCA AGTTTCAACA TTCAGGTCTG TCCCCAACAG GCACCACACC 66301 GGGGTGGACT CCCTGTGTAA CTTCTCGCCA CTGGCTCGGA GAGTAGACAG 66351 AGTTGCCATC TATGAGGAAT TTCTGCGGAT GACCCGGAAT GGTACCCAGC 66401 TGCAGAACTT CACCCTGGAC AGGAGCAGTG TCCTTGTGGA TGGGTATTCT 66451 CCCAACAGAA ATGAGCCCTT AACTGGGAAT TCTGACCTTC CCTTCTGGGC 66501 TGTCATCCTC ATCGGCTTGG CAGGACTCCT GGGACTCATC ACATGCCTGA 66551 TCTGCGGTGT CCTGGTGACC ACCCGCCGGC GGAAGAAGGA AGGAGAATAC 66601 AACGTCCAGC AACAGTGCCC AGGCTACTAC CAGTCACACC TAGACCTGGA 66651 GGATCTGCAA TGACTGGAAC TTGCCGGTGC CTGGGGTGCC TTTCCCCCAG 66701 CCAGGGTCCA AAGAAGCTTG GCTGGGGCAG AAATAAACCA TATTGGTCGG 66751 AAAAAAAAAA AAAAA

[0057]

Claims

1. An isolated nucleic acid molecule encoding CA125.

2. The isolated nucleic acid molecule of claim 1 comprising the sequence of SEQ ID NO: 4.

3. The isolated nucleic acid molecule of claim 2 wherein the sequence has at least about 70% homology with SEQ ID NO: 4.

4. The isolated nucleic acid molecule of claim 2 wherein said molecule is a fragment thereof.

5. An isolated nucleic acid molecule comprising the sequence shown in SEQ ID NO: 1.

6. The isolated nucleic acid molecule of claim 5 wherein the sequence has at least about 70% homology with SEQ ID NO: 1.

7. The isolated nucleic acid molecule of claim 5 wherein said molecule is a fragment thereof.

8. An isolated nucleic acid molecule comprising the sequence shown in SEQ ID NO: 2.

9. The isolated nucleic acid molecule of claim 8 wherein the sequence has at least about 70% homology with SEQ ID NO: 2.

10. The isolated nucleic acid molecule of claim 8 wherein said molecule is a fragment thereof.

11. An isolated nucleic acid molecule comprising the sequence shown in SEQ ID NO: 3.

12. The isolated nucleic acid molecule of claim 11 wherein the sequence has at least about 70% homology with SEQ ID NO: 3.

13. The isolated nucleic acid molecule of claim 11 wherein said molecule is a fragment thereof.

14. A polypeptide with the amino acid sequence selected from the group consisting of: (a) the amino acid sequence set forth in SEQ ID NO: 5; (b) an amino acid sequence having at least 50% sequence identity to said sequence; (c) a conservative variant of an one of (a) to (b); and (d) a fragment of any one of (a) to (c).

15. A purified antibody that selectively binds to an amino acid sequence of the CA125 protein:

(a) wherein the amino acid sequence of the CA125 protein comprises the amino acid sequence set forth in SEQ ID NO: 5;

(b) an amino acid sequence having at least 50% sequence identity to said sequence;

(c) a conservative variant of any one of (a) to (b); and

(d) a fragment of any one of (a) to (c).

16. The purified antibody of claim 15 wherein said sequence identity is at least 60%.

17. The purified antibody of claim 15 wherein said sequence identity is at least 70%.

18. The purified antibody of claim 15 wherein said sequence identity is at least 80%.

19. The purified antibody of claim 15 wherein said sequence identity is at least 90%.

20. A method to make a purified fragment of the CA125 polypeptide of SEQ ID NO: 5 comprising:

(a) expressing a portion of the isolated nucleic acid molecule set out in SEQ ID NO: 4 to obtain a fragment of the CA125 molecule; and

(b) purifying said fragment of the CA125 molecule.