Abstract: The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.
Type:
Application
Filed:
June 6, 1997
Publication date:
September 20, 2001
Inventors:
JERZY GOLIK, DOLATRAI VYAS, JOHN J. WRIGHT, HENRY WONG, JOHN F. KADOW, JOHN K. THOTTATHIL, WEN-SEN LI, MURRAY A. KAPLAN, ROBERT K. PERRONE, MARK D. WITTMAN
Abstract: The present invention relates to a method for preventing and/or reducing cellular and tissue damage caused by reactive oxygen metabolites (ROMs) released by phagocytic or endothelial cells in response to various disease states or pathologies. The methods of the present invention are useful in preventing and treating a variety of disease states or pathological situations in which ROMs are produced and released. The methods of the present invention contemplate reducing ROM-mediated damage by reducing the production and release of ROMs.
Type:
Application
Filed:
April 12, 2001
Publication date:
September 20, 2001
Inventors:
Kristoffer Hellstrand, Svante Hermodsson, Kurt R. Gehlsen
Abstract: The application discloses substituted norbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostics and a medicament comprising them
Abstract: Disclosed is the use of cloprostenol and fluprostenol analogues in combination with carbonic anhydrase inhibitors for the treatment of glaucoma and ocular hypertension and ophthalmic compositions therefor.
Type:
Application
Filed:
February 6, 2001
Publication date:
September 20, 2001
Inventors:
Thomas R. Dean, Jesse A. May, Verney L. Sallee, Louis Desantis
Abstract: It has been demonstrated that conjugated linoleic acid isomers with the first double bond in position 9 (cis) or 10 (trans), added exogenously, can be desaturated in position 6 by the cyanobacterium Spirulina platensis. The metabolites, 6-cis, 9-cis, 11-trans-octadecatrienoic and 6-cis,10-trans,12-cis-octadecatrienoic acids, which have not previously been characterized, were isolated by a combination of chromatographic techniques and the structures were confirmed by gas chromatography-mass spectrometry in the form of picolinyl ester and dimethyloxazoline derivatives.
Type:
Application
Filed:
December 18, 2000
Publication date:
September 20, 2001
Applicant:
Natural ASA
Inventors:
Antoni Ryszard Slabas, Josiah William Simon, William Walker Christie
Abstract: The present invention is directed to methods for alleviating the symptoms associated with peripheral neuropathy. The neuropathy may be the result of a genetically inherited condition, systemic disease or exposure to a toxic agent. A reduction or elimination of symptoms is obtained by administering the drug selegiline. The invention is also directed to a method for treating patients with cancer by administering a chemotherapeutic agent known to have a toxic affect on peripheral nerves together with selegiline.
Abstract: A composition for the transdermal administration of a drug, comprising: 0.05 to 50 wt % of the drug based on the total weight of the composition; 1 to 30 wt % of an absorption promoter consisting of a diethylene glycol ether and a sorbitan ester in a weight ratio ranging from 1:4 to 4:1, based on the total weight of the composition; and a pharmaceutically acceptable adhesive matrix.
Abstract: An injectable physiologically acceptable aqueous phase fluorocarbon emulsion, which has substantially no free fluorocarbon, has an excellent stability is prepared by a process of the invention. Typically, more than about 99.8 wt. % of the fluorocarbon remains in the size range of about 0.2 to 0.4 microns even after being stored at room temperature for one year or more in sealed containers under a non-oxidizing atmosphere. The emulsion is useful in medical applications, for example, coronary angioplasty, cancer therapy, among others.
Abstract: In a process for producing polyurethane foams by reacting isocyanates with compounds having at least two hydrogen atoms which are reactive toward isocyanate groups, the isocyanates used are (cyclo)aliphatic isocyanates and the reaction is carried out in the presence of substances which effect framework formation in the polyurethane foam.
Type:
Application
Filed:
February 12, 2001
Publication date:
September 20, 2001
Inventors:
Bernd Bruchmann, Armin Becker, Heniz-Dieter Lutter, Dietrich Scherzer, Harald Schafer
Abstract: Provided are a UV-curable pressure-sensitive adhesive composition comprising a photoinitiator which has a molar absorptivity at 365 nm of at least 1,000 mol−1·cm−1 and the maximum absorption wavelength of at least 420 nm on a long wavelength side; and an adhesive sheet having a layer of the composition disposed over a photo-transmitting base film. The pressure-sensitive adhesive sheet according to the invention can be cured even by exposure to ultraviolet rays at a low intensity or for short time so that it can contribute to energy saving and productivity improvement as a sheet for processing, fixation or surface protection of a semiconductor wafer.
Abstract: A water-based ink comprising (A) a coloring material; and (B) an aqueous dispersion of polymer particles comprising a water-insoluble graft copolymer having an acrylic polymer side chain (P) and a salt-formiing group (Q), wherein the acrylic polymer side chain (P) is a polymer made of at least one monomer represented by the formula (1):
Abstract: An ink composition comprising a resin having a certain chelate structure can realize an image possessing excellent rubbing/scratch resistance and at the same time can realize various properties on a high level required of ink compositions. The ink composition comprises a colorant, water, a water-soluble organic solvent, and fine particles of a polymer, the polymer having a ligand structure capable of combining with a metal ion to form a chelate.
Abstract: The present invention related to an ink for ink-jet comprising: a coloring composition containing coloring particulates dispersed in a water based medium, the coloring particulates containing an oil soluble dye and an oil soluble polymer; and wherein the coloring composition has wavelength of maximum absorption (&lgr; max(nm)) in the wavelength range from 510 to 560 nm and when the absorbance at the wavelength of maximum absorption (&lgr; max(nm)) is regarded as 1, the absorbance at a wavelength (&lgr; max+75 (nm)) is no more than 0.2 and the absorbance at a wavelength (&lgr; max−75 (nm)) is no more than 0.4.
Abstract: Benzotriazole UV absorbers substituted with an ultra long ester or amide moiety wherein the ester or amide group is a hydrocarbyl group of 25 to 100 carbon atoms or is a group of alkyl of 25 to 100 carbon atoms interrupted by 5 to 39 oxygen atoms and terminated with an omega—OH or an omega—OR group exhibit excellent stabilization efficacy while they concomitantly do not bloom when incorporated into polyolefin films. These benzotriazole UV absorbers also provide excellent protection to white, dyed, dipped, unscented and/or scented candle wax from discoloration and degradation.
Type:
Application
Filed:
December 20, 2000
Publication date:
September 20, 2001
Inventors:
Mervin Wood, Ramanathan Ravichandran, Douglas Wayne Horsey, Anunay Gupta, Deborah DeHessa, Luther A. R. Hall, Andrea Smith, Stephen Mark Andrews
Abstract: A description is given of an extrusion process for the preparation of a low-dust stabiliser, using a subcooled melt as granulation liquid, as well as of novel amorphous modifications of different stabilisers, including 2,2′-methylenebis(4-[1,1,3,3-tetramethylbutyl]-6-benzotriazol-2-yl-phenol), and of the &bgr;-crystalline modification of 2-(2-hydroxy-3,5-di-tert-butylphenyl)-5-chlorobenzotriazole and of the preparation thereof. The novel process affords products which are easy to handle and which are flowable, and the novel modifications have advantages as regards their preparation, processing and their use as stabiliser.
Type:
Application
Filed:
March 23, 2001
Publication date:
September 20, 2001
Inventors:
Daniel Thibaut, Andre Schmitter, Benjamin Breitenstein, Christoph Kleiner, Matthias von Frieling, Martin von Buren, Andre Geoffroy
Abstract: A stabilizer composition for polymers is provided comprising bis(2,4-dicumylphenyl) pentaerythritol diphosphite and at least one metal salt of the lactic acid, and optionally one or more additional phosphites and other antioxidants.
Abstract: Aluminum hydroxide having specific characteristics, and a tire tread rubber composition and a pneumatic tire employing the aluminum hydroxide, which allow grip performance and abrasion resistance to increase and rolling resistance to decrease and are superior in processibility, are provided.
Abstract: Ink jet recording media have a substrate coated on one or both sides with two layers of coating material. The first layer is a relatively inexpensive ink vehicle absorptive coating comprised in major part of a pigment component that is comprised in major part of relatively inexpensive but highly absorbent calcined clay. The second layer is an ink receptive coating comprised of relatively expensive constituents providing excellent print qualities. Because the first layer provides the important ink vehicle absorbing function, the ink receptive coating can be applied at much lower coat weights than would otherwise be required. This produces recording media having equal or better print qualities than a heavier single layer of the ink receptive material, and does so at much lower cost. Methods of making and applying coatings having high levels of calcined clay are key factors in producing the media.
Type:
Application
Filed:
April 19, 2001
Publication date:
September 20, 2001
Applicant:
Stora Enso North America, Corp.
Inventors:
Gary G. Schiller, Leonard J. Schliesman
Abstract: The present invention discloses an aqueous coating composition comprising 5 to 95 wt. % of an alkali-swellable core-shell addition polymer (I), and 95 to 5 wt. % of a polyurethane (II).
Type:
Application
Filed:
December 21, 2000
Publication date:
September 20, 2001
Inventors:
Jan Wilhelm Ernst Moos, Johannes Hubertus Van Diemen, Gertrude A. Broekroelofs
Abstract: Methods and apparati have been developed for producing a suspension of predominately amorphous polymer particles, wherein the method includes thermally treating a suspension that includes crystalline or semi-crystalline polymer particles. The thermal treatment includes (a) heating a suspension of polymer particles of an appropriate size to a temperature effective to cause the polymer to become amorphous, and then (b) cooling the suspension of amorphous polymer particles below the melting point of the polymer at a rate effective to prevent substantial coalescence of the polymer particles. The method and apparati are effective for use with a variety of polymers having suitable crystallization parameters, although polyhydroxyalkanoate (PHA) polymers are preferred, particularly in an aqueous suspension medium. For PHA polymers, the polymer particles subjected to treatment preferably are of a size of less than 5 &mgr;m, or more preferably less than 1.5 &mgr;m in diameter.
Abstract: The invention relates to a polymeric material on the basis of renewable raw materials, containing a reaction product from 10-90% by mass of a triglyceride with at least 2 epoxy and/or aziridine groups and 5-90% by mass of a polycarboxylic acid anhydride with 0.01-20% by mass of a polycarboxylic acid.
Abstract: The invention relates to a process for the hydrogenation of a polymer composed of diene monomer units and nitrile group containing monomer units in which crosslinks formed as a result of the hydrogenation are broken by adding, before, during or after the hydrogenation, a compound that satisfies the formula R1—N (H) —X (I) or (R1) (R2)C═N—Y (II), where R1 is a hydrogen atom, an alkyl or cycloalkyl group with 1-30 carbon atoms, or an aromatic group with 6-30 carbon atoms and
Type:
Application
Filed:
February 9, 2001
Publication date:
September 20, 2001
Inventors:
Johannes W. Belt, Jacobus A.A. Vermeulen, Nikhil K. Singha, Olav M. Aagaard, Mike Kostermann
Abstract: A process for improving the green strength of ethylene/&agr;-olefin/diene polymers is described comprising (A) selecting an ethylene/(&agr;olefin/diene polymer having a Mooney viscosity at 125 C up to about 80 and a percent gel (% gel) up to about 30 percent and (B) partially crosslinking the ethylene/&agr;-olefin/diene polymer selected in step (A) to make a modified ethylene/&agr;-olefin/diene polymer satisfying the equations MV≦100 and 1 W ≤ ( MS 2 - MS 1 MS 1 )
Abstract: The present invention is directed to crystalline, absorbable block/segmented copolymers which are the reaction product of a linear prepolymer which is a polytrimethylene dicarboxylate of succinic, glutaric, or adipic acid and either glycolide, 1-lactide, or mixtures thereof. Preferably the prepolymer is preliminarily end-grafted with a further monomer such as trimethylene carbonate or &egr;-caprolactone. The crystalline copolymers of this invention are tailored for fabrication into several forms of absorbable biomedical devices including monofilament sutures.
Abstract: Fluoroelastomers having copolymerized units of vinylidene fluoride major monomer, at least one other fluorinated major monomer, and at least one cure site monomer are prepared in an aqueous suspension polymerization process using an initiator consisting essentially of a solution of an oil soluble peroxide in a water-soluble hydrocarbon solvent.
Abstract: A catalytic composition is obtained by mixing at least one chromium compound with at least one aryloxy compound of an element M selected from the group formed by magnesium, calcium, strontium and barium, with general formula M(RO)2-nXn, where RO is an aryloxy radical containing 6 to 80 carbon atoms, X is a halogen or a hydrocarbyl radical containing 1 to 30 carbon atoms and n is a whole number that can take values of 0 to 2, and with at least one aluminum compound selected from hydrocarbylaluminum compounds (tris(hydrocarbyl)-aluminum, chlorinated or brominated hydrocarbylaluminum compounds) and aluminoxanes. The catalytic composition can be used in an ethylene oligomerization process, in particular to produce 1-hexene.
Abstract: A catalyst composition comprising (a) an iron-containing compound, (b) an organomagnesium compound and (c) a dihydrocarbyl hydrogen phosphite is disclosed for polymerizing 1,3-butadiene into syndiotactic 1,2-polybutadiene. The use of the catalyst composition of this disclosure avoids the use of environmentally detrimental components such as carbon disulfide and halogenated solvents. The melting temperature of the syndiotactic 1,2-polybutadiene can be varied from about 100 to about 190 ° C. by variations in the catalyst components and the component ratios. The ability to vary the melting temperature with a single catalyst composition is very desirable. The syndiotactic 1,2-polybutadiene can be used as a plastic or as an additive for rubber compositions wherein it can crosslink with conventional rubbers using conventional crosslinking agents.
Abstract: Linear, branched or crosslinked polymer, capable of being obtained by polymerization of N-alkylacrylamide, in which the alkyl radical is linear or branched and comprises from 1 to 6 carbon atoms, with one or more monomers chosen from cationic monomers, monomers comprising at least one partially salified or completely salified strong acid functional group or monomers comprising at least one partially salified or completely salified weak acid functional group. A method of preparing the polymer is also disclosed.
Type:
Application
Filed:
December 28, 2000
Publication date:
September 20, 2001
Inventors:
Francoise Candau, Joseph Selb, Paul Mallo, Olivier Braun
Abstract: This invention relates to methods and reactor devices for controlling the oxidation of hydrocarbons to dibasic acids, in the presence of a cobalt catalyst and a monobasic acid, such as acetic acid, by treating the catalyst from the reaction mixture, outside the oxidation zone, after the oxidation has taken place at least partially. In one preferred embodiment, the catalyst is reduced to contain, preferably predominantly and more preferably substantially, cobalt ions in valence II, and at least partially precipitated by de-watering and/or thermal treatment. In a different preferred embodiment, the catalyst in the reaction mixture is first oxidized or maintained, preferably predominantly and more preferably substantially, at valence III, the reaction mixture is de-watered, the catalyst is reduced preferably predominantly and more preferably substantially, to valence II, causing precipitation either spontaneously at a predetermined temperature or after further thermal treatment.
Type:
Application
Filed:
April 5, 2001
Publication date:
September 20, 2001
Inventors:
Eustathios Vassiliou, Mark W. Dassel, Ader M. Rostami, Douglas J. Dudgeon, David C. DeCoster
Abstract: The present invention relates to ligands which bind to human tumour necrosis factor alpha (TNF) in a manner such that upon binding of these ligands to TNF the biological activity of TNF is modified. In preferred forms the ligand binds to TNF in a manner such that the induction of endothelial procoagulant activity of the TNF is inhibited; the binding of TNF to receptors on endothelial cells is inhibited; the induction of fibrin deposition in the tumour and tumour regression activities of the TNF are enhanced; and the cytotoxicity and receptor binding activities of the TNF are unaffected or enhanced on tumour cells. The ligand is preferably an antibody, F(ab) fragment, single domain antibody (dABs) single chain antibody or a serum binding protein. It is preferred, however, that the ligand is a monoclonal antibody or F(ab) fragment thereof.
Abstract: A reagent for conjugation to a biomolecule, wherein the reagent is a single molecule with at least three functional parts and has schematic structure (I): wherein a trifunctional cross-linking moiety is coupled to b) an affinity ligand via a linker 1, said affinity ligand being capable of binding with another molecule having affinity for said ligand, to c) an effector agent, optionally via a linker 2, said effector agent exerting its effect on cells, tissues and/or humorous molecules in vivo or ex vivo, and to d) a biomolecule reactive moiety, optionally via a linker 3, said moiety being capable of forming a bond between the reagent and the biomolecule.
Abstract: This invention provides isolated nucleic acids encoding a mammalian GABABR2 polypeptide, an isolated GABABR2 protein, vectors comprising isolated nucleic acid encoding mammalian GABABR2 polypeptides, cells expressing mammalian GABABR1/R2 receptors, antibodies directed to an epitope on mammalian GABABR2 polypeptides or mammalian GABABR1/R2 receptors, nucleic acid probes useful for detecting nucleic acids encoding mammalian GABABR2 polypeptides, antisense oligonucleotides complementary to unique sequences of nucleic acids encoding mammalian GABABR2 polypeptides, nonhuman transgenic animals which express DNA encoding normal or mutant mammalian GABABR1/R2 receptors, as well as methods of screening compounds acting as agonists or antagonists of mammalian GABABR1/R2 receptors.
Type:
Application
Filed:
March 27, 2001
Publication date:
September 20, 2001
Applicant:
Synaptic Pharmaceutical Corporation
Inventors:
Kenneth A. Jones, Thomas M. Laz, Beth Borowsky
Abstract: A batch process for obtaining polynucleotide fragments, such as dsDNA, having a selected size from a mixture of polynucleotide fragments including the steps of a) applying a solution of the mixture of polynucleotide fragments and a counterion agent to a binding medium having a hydrophobic surface; b) contacting the binding medium with a first stripping solvent and counterion agent, the first stripping solvent having a concentration of organic component sufficient to release from the binding medium all polynucleotide fragments having a size smaller than the selected size, and removing the first stripping solvent from the binding medium; and c) contacting the binding medium with a second stripping solvent having a concentration of organic component sufficient to release from the binding medium the polynucleotide fragments having the selected size, and removing the second stripping solvent from the binding medium. The binding medium can be organic polymer or inorganic particle beads.
Type:
Application
Filed:
January 16, 2001
Publication date:
September 20, 2001
Inventors:
Douglas T. Gjerde, Robert M. Haefele, Paul D. Taylor
Abstract: A compound represented by the formula (1) which is useful as an agricultural fungicide or an intermediate thereof can be obtained by reacting a compound of the general formula (2) with a compound of the general formula (3) in the presence of an acid-and reducing the resulted reaction mixture.
Type:
Application
Filed:
February 20, 2001
Publication date:
September 20, 2001
Inventors:
Hiroyuki Katsuta, Seiichi Ishii, Kanji Tomiya, Kenji Kodaka
Abstract: Disclosed are a novel transition metal compound represented by the following general formula (I), a catalyst component for olefin polymerization comprising same, a catalyst for olefin polymerization comprising said catalyst component, and a process for the preparation of an a-olefin polymer: 1
Abstract: A 6-aminocarbonylmethyl-4H-2,3-dioxin-4-one compounds can be produced by reacting a 6-halomethyl-4H-2,3-dioxin-4-one compound with a primary or secondary amine and carbon monoxide. The reaction may be carried out in the presence of a catalyst comprising a platinum group metal. 3-oxopentanedicarboxylic acid monoamides and 3-oxopentanedicarboxylic acid amide esters can be are produced by reacting 6-aminocarbonylmethyl-4H-2,3-dioxin-4-one compound with an alcohol or water. Using such intermediates, 6-aminocarbonylmethyl-4H-2,3-dioxin-4-one compound, 3-oxopentanedicarboxylic acid amide esters can provide in an easy and simple and efficient manner.
Abstract: The invention provides a process for purifying gallium alkoxides by decreasing the amount of impurity chlorine contained therein, gallium alkoxides which are useful as raw materials for the formation of dielectrics containing gallium oxide and as raw materials for the syntheses of compounds for photoelectronics. Gallium isopropoxide containing 0.98 weight percent of chlorine and potassium isopropoxide of 1.4 equivalents to the impurity chlorine are refluxed in toluene as a solvent for 5 hours, the solvent is distilled away, and the residue is simply distilled under vacuum to obtain gallium isopropoxide containing 0.022 weight percent of the chlorine in a 89% yield.
Abstract: The present invention relates to 3-cyano-2,4,5-trifluorobenzoyl fluoride and to intermediates for its preparation and to the process for the preparation of 3-cyano-2,4,5-trifluoro-benzoyl fluoride, which starts from 5-fluoro-1,3-xylene (VIII); which is bichlorinated in the ring in the presence of a catalyst under ionic conditions to give 2,4-dichloro-5-fluoro-1,3-dimethylbenzene (VII). The latter is chlorinated in the side chains under free-radical conditions to give 2,4-dichloro-5-fluoro-3-dichloromethyl-1-trichloromethylbenzene (VI).
Abstract: The present invention relates to a method of recovering terephthalic acid from a material containing poly(ethylene terephthalate) (P.E.T.) in the form of bottles, by making said material react, in the absence of water, with a reagent consisting of one or more metal salts of a weaker acid than the terephthalic acid, until a water-soluble compound is obtained, and subsequently carrying out dissolution in water and acidification.