Abstract: A phosphorus atom-containing fluorinated cation exchange membrane substantially constituted with the following repeating units (A) and (B), and a proton conduction type fuel cell using the membrane as a solid polymeric electrolyte are provided. One embodiment for the membrane is useful as a perfluoro cationic exchange membrane for use in electrolysis of sodium chloride even under severe electrolytic conditions of higher concentration, higher temperature and higher electric density. (in which m is 0 or 1, n is 2 or 3, X, Y represents H or C6H4SO3H and the ratio for the number of repeating units is (A)/(B)=1.5 to 15).

Abstract: A process for making a self-dispersible, radiation curable coating composition involving: (a) providing a cationic oligomer; (b) providing an epoxy functional monomer; (c) providing a surfactant component; (d) providing a transfer agent; (e) providing a photoinitiator; and (f) mixing (a)-(e) to form the coating composition.

Abstract: A cement dispersant (especially a dispersant for concretes with ultrahigh performance) comprising as a main component a water-soluble amphoteric copolymer obtained by copolymerizing (A) a polyamide-polyamine of an alkylene oxide adduct thereof with (B) (meth)acrylic acid or an alkali metal, ammonium, or alkanolamine salt thereof and (C) a polyalkylene glycol ester of (meth)acrylic acid in an A/B/C ratio of (10-40)/(10-40)/(50-80) (wt. %); and a concrete composition (especially an ultral high-performance concrete) containing the dispersant. The dispersant satisfies all of a water-reducing effect, slump flow retention, strength development, etc.

Abstract: An organohybrid-based damping material for controlling unwanted vibration and noise, an organic damping improver exhibiting piezoelectric, dielectric and electroconductive effects, and their producing methods, are provided. The damping material comprises a polymer matrix having a polar side chain and a damping improver composed of a compound containing basic nitrogen and a phenol-based compound. The damping material shows an excellent damping properties, alleviates the functional deterioration, and is applicable to different application temperature regions and wide areas.

Abstract: A molding composition suitable for the preparation of glazing is disclosed. The composition contains a transparent thermoplastic polymer and a phthalocyanine or naphthalocyanine. Also disclosed is a method for preparing the composition.

Abstract: A polyolefin composition having high resistance to degradation, said composition formed by combining components comprising at least one polyolefin component produced from a transition metal halide catalyst, bis(2,4-dicumylphenyl)pentaerythritol diphosphite, triisopropanolamine, a hydrotalcite component, and at least one phenol component.

Abstract: The present, invention relates to a process for producing a fabric-elastomer composite that, when transfer or film coated, is preferable for use as an artificial leather substrate. The inventive procedure involves (a) producing an elastomer composition of at least four ingredients (an anionically-stabilized waterborne polymer dispersion, an acid-generating chemical, a cloud-point surfactant, and a foam-stabilizing surfactant); (b) incorporating sufficient gas into the liquid mixture to generate a spreadable foam; (c) applying the foam onto a porous textile substrate; (d) heating said foamed fabric until the elastomer coagulates over the fabric substrate; and (e) drying the resultant composite without destroying the coagulated structure. The resultant composite obtains a suppleness that is similar to that of leather and a surface that is suitable for transfer coating to produce artificial leather. The composite may be utilized as upholstery fabric in furniture or in automobiles, apparel, and the like.

Abstract: A polyester resin composition containing, as a resin component, a polyester with its main component formed from a polytrimethylene terephthalate and having an intrinsic viscosity of 0.4 to 2, which satisfies the following conditions (1) to (3): (1) the polyester resin composition is composed of a polyester resin component comprising 90% by weight or more of a polytrimethylene terephthalate; (2) the polyester resin composition contains 0.01 to 3% by weight of titanium oxide having an average particle size from 0.01 to 2 &mgr;m; and (3) the polyester resin composition contains 25 or less/mg of the resin of agglomerates of titanium oxide particles which agglomerates have a lengthwise size exceeding 5 &mgr;m. A polytrimethylene terephthalate-based polyester fiber, having a low frictional coefficient, excellent in wear resistance, and showing a suitable luster and a delustered effect, can be stably spun and drawn by applying a melt spinning method to the polyester resin composition.

Abstract: The present invention is a process for preparing high concentration polyvinyl alcohol (PVA) aqueous mixtures, wherein the PVA solid concentration is at least 14% in the mixture.

Abstract: Disclosed is a dispersant obtainable by reacting (i) a di- or polyfunctional isocyanate with (ii) an HX-terminated polymeric compound, where X is COO, O, S or NR1 and R1 is H or C1-C6-alkyl; and either (iii) an HY-terminated homopolymer of a monomer selected from the group consisting of N-vinylamides, N-vinyllactams and vinyl- or allyl-substituted nitrogenous heterocycles or copolymer of one or more of the monomers mentioned and optionally further monomers, where Y is COO, O, S or NR2 and R2 is H or C1-C6-alkyl; or (iv) an HY-functional organic phosphonic ester, where Y is as defined above. The dispersant is especially useful for dispersing pigments and for preparing inkjet inks.

Abstract: A fast hardening clear coating composition for repairing a clearcoat/colorcoat finish of a vehicle, which composition is capable of being wet sanded, buffed or polished to a high gloss finish on the same day of application, comprising a film forming binder and an organic liquid carrier, where the binder contains a hydroxyl component comprising a hydroxyl-containing acrylic polymer and a hydroxyl-terminated polyester oligomer, and an organic polyisocyanate crosslinking component, at least portion of which comprises a trimer of isophorone diisocyanate, where the composition further contains, as a combined curing catalyst, at least one dialkyl tin aliphatic carboxylate, at least one tertiary aliphatic mono or diamine, and at least one aliphatic carboxylic acid, in an effective amount such that the clear coating composition on curing at ambient temperatures is in a water spot free and sufficiently hard state for sanding or buffing within about 4 hours after application or on cool down when baked under normal cond

Abstract: Acrylic Modified Fluoropolymers based on vinylidene fluoride polymers are disclosed wherein the acrylic phase is capable of entering into crosslinking reactions. The final cured products provide superior solvent extractability resistance to the fluoropolymer phase.

Abstract: The present invention relates to a new liquid, storage-stable coating composition, which is suitable for the production of coatings which have an outstanding resistance to external weathering, and binders thereof which are composed of a hardener component comprising an aminoplast resin and/or a blocked polyisocyanate and a specific polyol component of selected units, and to its use for the production of weathering-resistant coatings on any desired heat-resistant substrates.

Abstract: This invention relates to polymeric thermoplastic moldable compositions comprising poly(alkylene carbonates), which are useful in manufacturing of articles which may be manipulated and shaped by their user, but regain their shape after distortion. These compositions are free from toxic compounds and have a glass transition temperature from about 15° C. to about 132° C. These compositions are useful in manufacturing of articles such as toys, utensils to convey solids or liquids to the mouth, soothing articles (i.e., teething rings and pacifiers) and articles which support food (i.e., candy/confection sticks or holders.) They are most useful in manufacturing of children's toys and products.

Abstract: There are provided a process for producing a catalyst for &agr;-olefin polymerization, which comprises the step of contacting (1) a solid catalyst component having Ti, Mg and a halogen as essential components, (2) an organoaluminum compound and (3) a compound having a —C—O—C—O—C— bond group in a closed ring structure with one another; and a process for producing an &agr;-olefin polymer, which comprises the step of homopolymerizing or copolymerizing an &agr;-olefin in the presence of a catalyst for &agr;-olefin polymerization produced by the above process.

Abstract: Shear-thinning ethylene/&agr;-olefin and ethylene/&agr;-olefin/diene monomer interpolymers that do not include a traditional branch-inducing monomer such as norbornadiene are prepared at an elevated temperature in an atmosphere that has little or no hydrogen using a constrained geometry complex catalyst and an activating cocatalyst.

Abstract: Initiators for nitroxide-mediated radical polymerizations are described. The initiators have an azlactone or ring-opened azlactone moiety to provide telechelic (co)polymers.

Abstract: An acid dianhydride, together with a diamine, is heated in an organic polar solvent in the presence of &ggr;-caprolactone or &bgr;-butyrolactone as an acid catalyst to prepare a polyimide having an average molecular weight of 10,000 to 300,000. This production process can realize the production of a polyimide which is soluble in a solvent and has high processability and stability.

Abstract: The invention describes polyamides having both strongly hydrophilic groups and unsaturated groups, the polyamides consequently being water-dispersible and curable. The hydrophilic groups are distributed along the chain, whereas the unsaturated groups are located at the ends. The polyamides of the invention are useful in many applications, especially in the preparation of intimate blends of polyamides with vinyl, acrylic and/or styrene polymers.

Abstract: Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for making block copolypeptides and related protocols for adding aminoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains by exposing the NCA to solutions containing polyaminoacid chains having an amido amidate metallacyle end groups and reacting the NCA with the amido containing metallacyle end group so that the NCA is added to the polyaminoacid chain. Addition methods include means of controlling the addition of aminoacid-N-carboxyanhydrides to polyaminoacid chains by reacting NCAs with initiator molecules and allowing initiator complexes to open the ring of the NCAs through oxidative addition across either the O—C5 or O—C2 anhydride bond resulting a controlled polypeptide polymerization. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.

Abstract: The present invention relates to nucleotide sequences encoding a modulator of NF-&kgr;B, and to the polypeptides encoded by the nucleotide sequences. In particular, the invention relates to nucleotide sequences and the polypeptides encoded thereby, wherein the polypeptides are involved in the response to NF-&kgr;B-activating stimuli, including HTLV-1 Tax, LPS, PMA and IL-1. The invention also relates to antibodies to the modulator of NF-&kgr;B, methods of detecting modulator of NF-&kgr;B using the antibodies, methods of treatment associated with NF-&kgr;B activation and to methods of identifying compounds which modulate the activity of the modulator of NF-&kgr;B.

Abstract: Light emitting compounds of the formula where R1 is a light-emitting moiety, R2 is a CRF-related peptide and fragment, derivative or analog thereof and L is a linker moiety, which may be present or absent. The peptide is linked at a first amino acid position to (C—X) which, in turn, is selected from the group including C═O, C═S, CH(OH), C═C═O, C═NH, CH2, CH(OR), CH(NR), CH(R), CR3R4, and C(OR3)OR4 where R, R3, and R4 are alkyl moieties or substituted alkyl moieties. Optionally the compound may include a linker moiety between the peptide and the C—X binding group. Preferably, the compound exhibits substantial biological activity in the presence of receptors having affinities for CRF-related peptides.

Abstract: The present invention relates to isolated DNA encoding novel estrogen receptors, the proteins encoded by said DNA, chimeric receptors comprising parts of said novel receptors and uses thereof.

Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKip3, antibodies to HsKip3, methods of screening for HsKip3a modulators using biologically active HsKip3, and kits for screening for HsKip3a modulators.

Abstract: The present invention provides a DNA expressed at high frequency in mesangial cells and a protein (Meg-4) encoded by this DNA. These substances are useful in, for example, identifying mesangial cells and detecting abnormalities in mesangial cells. Moreover, the above protein would be helpful for clarification of the functions of mesangial cells and, in its turn, for clarification of the causes of diseases relating to mesangial cells. This protein is expectedly applicable to the treatment, diagnosis, and such of diseases relating to mesangial cells.

Abstract: The present invention provides a novel MHRII-associated protein designated MHRII-AP62 and antibodies immunoreactive with the MHRII-AP62 protein. Also provided are kits containing these antibodies and methods of using the antibodies for the detection of the MHRII-AP62 protein. The present invention also provides for a nucleic acid encoding the MHRII-AP62 protein and nucleic acid probes for use in the detection of the MHRII-AP62 protein. Further provided by the present invention are agents that mimic the activity of the MHRII-AP62 protein by binding to the MHRII, agents that inhibit the activity of the MHRII-AP62 protein by binding to the MHRII-AP62 protein, or by binding to the nucleic acid encoding the MHRII-AP62 protein, and methods of using these agents to treat cancer and cancer causing diseases.

Abstract: The present invention provides antibodies that bind to the growth differentiation factor-7.

Abstract: A novel subtype of the P2-purinergic receptor, referred to as the P2U2 receptor, is disclosed. This receptor is activated by four of its agonists in the following order of specificity: UTP>UDP>ADP>ATP. Nucleic acids encoding the receptor, antibodies that bind to the receptor and associated screening and therapeutic methods also are disclosed.

Abstract: Isolated antibodies to Invaplex; novel compositions comprising immunoglobulins directed to invasin proteins and LPS from gram negative bacteria that selectively bind to Invaplex, and do not bind to the individual components of Invaplex.

Abstract: Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.

Abstract: This invention relates to a method for selectively isolating IgY(&Dgr;Fc) avian antibodies from IgY avian antibodies. For example, the method includes: (a) providing an aqueous fraction from yolk of an egg of an anseriform bird; (b) precipitation IgY antibodies using a first precipitant salt; and (c) precipitating the IgY(&Dgr;Fc) antibodies from a supernatant using a second precipitant salt to provide an isolated preparation enriched for IgY(&Dgr;Fc) antibodies.

Abstract: The invention relates to compositions, systems, and methods for simultaneously detecting the presence and quantity of one or more different compounds in a sample using aptamer beacons. Aptamer beacons are oligonucleotides that have a binding region that can bind to a non-nucleotide target molecule, such as a protein, a steroid, or an inorganic molecule. New aptamer beacons having binding regions configured to bind to different target molecules can be used in solution-based and solid, array-based systems. The aptamer beacons can be attached to solid supports, e.g., at different predetermined points in two-dimensional arrays. The invention includes devices, methods, and computer software for carrying out the methods.

Abstract: The invention relates to a nucleic acid marker ladder which is a restriction endonuclease digest, wherein a nucleic acid restriction endonuclease digest is a collection of nucleic acid fragments resulting from complete digestion of one or more nucleic acids by one or more restriction endonucleases; the restriction endonuclease digest contains at least 3 fragments; and the size of the fragments in base pairs is a multiple of an integer, wherein the integer is 10 or more.

Abstract: This invention relates to novel human organic anion transporter polypeptides and genes encoding such polypeptides. The invention is directed towards the isolation, characterization and use of human organic anion transporter polypeptides for pharmacological screening of substrates, analogues of substrates, and modulators of human organic anion proteins. This invention also provides cell cultures, which stably contain nucleic acid sequences encoding human organic anion transport polypeptides. Such cell lines are useful for screening compounds in vitro to identify and characterize modulators, inhibitors and substrates of human organic anion transporter polypeptides.

Abstract: Nucleic acids encoding mammalian, e.g., primate, IL-1&zgr;, purified IL-1&zgr; polypeptides and fragments thereof. Binding proteins, e.g., antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.

Abstract: A health supplement composition is disclosed. The health supplement composition contains a solid health supplement material that is separated from a condensed soy molasses material. The solid health supplement material contains at least two isoflavones where one of the isoflavones is either glycitein or glycitin.

Abstract: The present invention provides for the preparation &bgr;-adenine nucleosides by coupling an adenine derivative containing an unprotected exocyclic amino group at the C-6 position and a blocked arabinofuranosyl derivative, in the presence of a base and solvent. The present invention also provides for the stereoselective preparation of 2-deoxy-&bgr;-D-adenine nucleosides wherein a blocked 2-deoxy-&agr;-D-arabinofuranosyl halide is coupled with the salt of an adenine derivative. The forgoing aspects of the present invention are utilized in the preparation of a clofarabine composition wherein the ratio of &bgr; to &agr;-anomer is at least 99:1.

Abstract: A process for making nevirapine, comprising the following steps: (a) reacting a 2-halo-3-pyridinecarbonitrile of the formula wherein X is a fluorine, chlorine, bromine or iodine atom, preferably chlorine or bromine, with cyclopropylamine, to yield 2-(cyclopropylamino)-3-pyridinecarbonitrile; (b) hydrolyzing the 2-(cyclopropylamino)-3-pyridinecarbonitrile to yield 2-(cyclopropylamino)-3-pyridine carboxylic acid; (c) isolating the 2-(cyclopropylamino)-3-pyridine carboxylic acid from the reaction medium; (e) treating the 2-(cyclopropylamino)-3-pyridine carboxylic acid with a chlorinating agent, to yield 2-(cyclopropylamino)-3-pyridinecarbonyl chloride; (f) reacting the 2-(cyclopropylamino)-3-pyridine carbonyl chloride with a 2-halo-4-methyl-3-pyridinamine of the formula wherein X is a fluorine, chlorine, bromine or iodine atom, preferably chlorine or bromine, to produce an N-(2-halo-4-methyl-3-pyridinyl)-2-(cyclopropylamino)-3-pyridinecarboxamide; and (g) cyclizing the N-

Abstract: The present invention relates to a process for preparing 4,6-diaminopyrimido[5,4-d]pyrimidines of formula I, wherein R1 to R4 have the meanings given in claim 1, as well as new intermediate products which are involved in this process.

Abstract: A method for the preparation of aryl methyl ketones converts a variety of ethyl arenas to the corresponding aryl methyl ketones using a dioxygen-containing gas as the oxidant. The catalyst used for the reaction is a metal complex bearing general formulas as disclosed.

Abstract: The invention relates to a novel method for preparing 2-(4-chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]propionic acid, also known as Rebamipide represented by the formula I and useful for treatment of peptic ulcer from alkyl 2-(4-chlorobenzoylamino)-2-alkoxycarbonyl-3-[2(1H)-quinolinon-4-yl]propionate represented by the formula II in the presence of a base solution for hydrolysis and decarboxylation to remove a carboxyl group.

Abstract: The subject invention provides pharmaceutical compounds useful in the treatment of Type II diabetes. These compounds are advantageous because they are readily metabolized by the metabolic drug detoxification systems. Particularly, thiazolidinedione analogs that have been designed to include esters within the structure of the compounds are provided. This invention is also drawn to methods of treating disorders, such as diabetes, comprising the administration of therapeutically effective compositions comprising compounds that have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester-containing thiazolidinedione analogs are also taught.

Abstract: The present invention relates to a process for preparing 5-amino-N-phenyl-1,2,4-triazole-3-sulfonamides of the formula (I) where X is halogen, cyano or nitro, R is hydrogen or optionally halogen-substituted C1-C4-alkyl, and n is 1 or 2, by reacting 5-amino-3-chlorosulfonyl-1,2,4-triazole of the formula (II) with substituted anilines of the formula (III) where X, n and R are as defined for formula (I), in the absence of a solvent.

Abstract: Acrylic esters containing fluorine at &agr;-position and having a lactone ring introduced into the ester side chain thereof are novel. Polymers obtained from the acrylic esters have a high transparency to VUV and good adhesion to substrates and are used to formulate chemically amplified resist compositions for lithographic microfabrication.

Abstract: The invention relates to the use of compounds of the formula I in which X is the divalent radical of oxygen, a carbonyl radical, optionally aliphatically substituted imino or the radical ═CR9R10, Y is a carbonyl group or the radical ═CR9R10, R1 and R2 are identical or different electron-withdrawing radicals, chosen from the group consisting of cyano, alkyl- or arylcarbonyl, alkyloxy- or aryloxycarbonyl, optionally substituted aminocarbonyl, alkyl- or arylsulfinyl, alkyl- or arylsulfonyl and optionally substituted aminosulfonyl, R3 is a hydrogen atom, a cyano, hydroxyl, carboxyl or aminocarbonyl group or a C5-C20-aryl radical or C1-C20-alkylradical optionally bonded via an oxygen bridge, an aminocarbonyl bridge or oxycarbonyl bridge, R4 is a hydrogen atom, a hydroxyl group, an amino group, or a C5-C20-aryl radical or C1-C20-alkyl radical optionally bonded via an oxygen bridge, and R5 to R10 independently of one another are hydrogen or C1-C20-alkyl radicals and where in additio

Abstract: The present invention provides piperine and analogues or derivatives thereof for the treatment of skin conditions treatable by stimulation of melanocyte proliferation, such as vitiligo, and also for treating skin cancer. The piperine and analogues or derivatives thereof may also be used to cosmetically promote or enhance the natural coloration of the skin.

Abstract: A process for removing polyol impurities from a sorbitan ester solution involving: (a) providing a sorbitan ester solution containing polyol impurities; (b) adding to the sorbitan ester solution a clarifying-effective amount of a silica component; (c) adsorbing the polyol impurities from the sorbitan ester solution onto the silica to form a mixture of sorbitan ester and polyol-containing silica; and (d) removing the polyol-containing silica from the sorbitan ester solution.

Abstract: This invention relates to a kind of white wax and its manufacturing method, particularly the white wax extracted from animal fat and sebum as a nontoxic, non-hazardous product of superb moistening that enhances skin's elasticity while keeping skin from cracking. The white wax in reference is made of animal fat and sebum, duly crushed after pre-treatment of high-temperature sterilization and deodorization and removal of impurities, allowing the fat and sebum to mix. The mixed raw material is heated after undergoing rapid refrigeration before being minced into sticky colloid when cooled and when squeezed and screened, the sticky discharges gummy matter which, when mixed and neutralized with emulsifying agent, allowing the gummy matter transform from greasy substance into watery white wax.

Abstract: The invention relates to a continuous method for producing a cross-linked unsaturated fatty acid-based or fatty acid ester-based bonding agent, an elastic bonding agent produced according to said method and the use of said elastic bonding agent.

Abstract: The invention relates to a non-catalysed method for the synthesis of straight-chain aliphatic carboxylic acids by oxidation of straight-chain aldehydes with oxygen-containing gas mixtures. The invention is characterised in that during the novel process of oxidation branched aldehydes are present in the reaction mixture.