Abstract: In a uniformly copolymerized one-part polyurethane resin composition with improved processing behaviors and chemical resistance, the one-part polyurethane resin composition comprises about 20 to 50% by weight of a hard segment and about 50 to 80% by weight of a soft segment. The hard segment reduces drying time and recoating time of a film coated by the composition, and the soft segment improves processing behaviors of the film including rolling and spraying properties. The one-part polyurethane resin composition may further comprise a catalyst. The catalyst may regulate film drying time and improve gloss of a coated film. Thus, the resin composition may be applied in various fields.

Abstract: A method for making an amine-terminated polyarylene polyether thermoplastic in which a liquid/solid slurry reaction mixture is formed in an oxygen-free atmosphere. The reaction mixture is composed of a dihydroxyaromatic compound, a dihaloaromatic compound, an amino-hydroxyaromatic compound, a weak base, an aprotic polar solvent and a non-aromatic azeotrope former which is substantially imiscible with the aprotic polar solvent, said azeotrope former consisting of a molecule which has from 6 to 10 carbon atoms. The reaction mixture is refluxed at an elevated temperature to eventually produce a solution of the amine-terminated polyarylene polyether in the polar solvent. The method is designed for use in producing large amounts of thermoplastic in a simple, efficient and reliable manner.

Abstract: A phenolic resin obtainable by reacting a dihydroxy compound of the following formula (1) with a phenolic compound, wherein the dihydroxy compound is partially dehydrated.

Abstract: Polythiophenes of the formula wherein R and R? are side chains; A is a divalent linkage; x and y represent the number of unsubstituted thienylene units; z represents the number of groups, and wherein the sum of x and y represents the number of groups; m represents the number of segments; and n represents the degree of polymerization.

Abstract: The invention provides a sterically hindered polymer that comprises a water-soluble and non-peptidic polymer backbone having at least one terminus covalently bonded to an alkanoic acid or alkanoic acid derivative, wherein the carbon adjacent to the carbonyl group of the acid or acid derivative group has an alkyl or aryl group pendent thereto. The steric effects of the alkyl or aryl group allow greater control of the hydrolytic stability of polymer derivatives. The polymer backbone may be poly(ethylene glycol).

Abstract: The present invention relates to a novel drug delivery system of use in the improved delivery of drug therapeutic agents into target cells. The system comprises a drug moiety linked to a carrier moiety wherein the carrier moiety comprises a homeobox peptide or a fragment or derivative thereof.

Abstract: Disclosed herein are novel human nucleic acid sequences that have homology to thymosin, ephrin A receptors, proteoglycans and fibromodulin. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving these novel nucleic acids and proteins.

Abstract: It is intended to construct a screening method, etc. for searching for compounds which are capable of binding to apolipoprotein A-I and thus promote or inhibit the binding of a cubulin fragment to apolipoprotein A-I, and provide preventives or remedies containing compounds obtained by the above screening method, etc. These compounds, etc. are usable in preventives and remedies for various diseases in which cubulin participates and the like.

Abstract: The present invention relates to recombinant gelatins and compositions thereof, and methods of producing and using the same.

Abstract: The recovery of protein from canola oil seed meal and other oil seed meals in the preparation of canola or other oil seed protein isolate is improved in comparison to conventional toasted meal by the use of a meal which has been air-desolventized at a temperature below about 50° C.

Abstract: Disclosed are compositions and methods for producing fusion proteins with reduced immunogenicity. Fusion proteins of the invention include a junction region having an amino acid change that reduces the ability of a junctional epitope to bind to MHC Class II, thereby reducing its interaction with a T-cell receptor. Methods of the invention involve analyzing, changing, or modifying one or more amino acids in the junction region of a fusion protein in order to identify a T-cell epitope and reduce its ability to interact with a T cell receptor. Compositions and methods of the invention are useful in therapy.

Abstract: Four novel members of the EPH sub-family of receptor protein tyrosine kinases are disclosed. Nucleic acid sequences encoding receptor proteins, recombinant plasmids and host cells for expression, and methods of producing and using such receptors are also disclosed.

Abstract: An isolated molecule which comprises an antibody specifically bindable with a binding affinity below 20 nanomolar, preferably below 10 nanomolar, to a human major histocompatibility complex (MHC) class I being complexed with a HLA-restricted antigen and optionally further comprises an identifiable or therapeutic moiety conjugated to the antibody.

Abstract: Analogs of saquinavir functionalized at the quinoline portion of the molecule are described. These include pyridyl analogs (replacing the quinoline ring) with a functional handle out of the ring allowing for elaboration with linkers terminated by a functional group such as an activated ester which are useful for attaching the molecule to other entities such as proteins, polysaccharides, and the like. Analogs of saquinavir derivatized out of the quinoline ring are also described.

Abstract: The invention provides an agent for conferring resistance comprising a lectin as an effective component, which are able to confer resistance against external stimuli to animal cells, particularly mammalian cells, and to their cultured cells and various tissues in the living bodies. The agent for conferring resistance to external stimulus according to the invention can confer to such animal cells and/or tissues resistance against mechanical stimuli and/or proteolytic reactions, and thereby enhance graft fixation of the cells and/or tissues, as well as transplant tissues obtained by culturing them.

Abstract: The present invention relates to a reactive orange dye containing vinyl sulfone and more particularly, to the dye which have 6(7)-alkoxycarbonylamino-4-hydroxy-2-naphthalenesulfonic acid as a chromophore and aminophenyl-?-ethylsulfone derivative as an azo coupler. This dye provides excellent fastness in terms of light, washing, perspiration and chlorine as well as better dyeing yield than other monofunctional reactive dye. In Formula (1), M is alkaline metal atom; Z is —O—SO3M or OC(O)CH3; R is alkyl group having 1–4 of carbon atom; and a position of C6 or C7 is substituted with carbamate group.

Abstract: The present invention provides a nucleotide having the formula, Sig-PM-SM-BASE wherein PM is a phosphate moiety, SM is a sugar moiety and BASE is a pyrimidine, purine or 7-deazapurine moiety. PM is attached to the 3? or the 5? position of the sugar moiety when the nucleotide is a deoxyribonucleotide and at the 2?, 3? or 5? position when the nucleotide is a ribonucleotide. BASE is attached to the 1? position of SM from the N1 position when BASE is a pyrmidine or the N9 position when BASE is a purine or 7-deazapurine. Sig is covalently attached to PM directly or via a chemical linkage, and represents a detectable moiety covalently attached to SM directly or through a linkage group. Also provided are an oligo- or polynucleotide comprising at least one such phosphate-moiety labeled nucleotide, and other compositions including those wherein a polypeptide is terminally ligated or attached to the oligo- or polynucleotide.

Abstract: Disclosed is a method and apparatus for the isolation of DNA or cell nuclei or a mixture thereof from cell samples in a CD device. The method includes treating a suspension of whole cells with a lysis reagent so as to lyse the cytoplasmic membrane and at least some of the nuclear membranes, and introducing the lysate into micro-channels of a microfabricated apparatus in which each of the micro-channels is provided with a barrier disposed in the channel to impede the passage or flow of DNA and cell nuclei while allowing the passage of liquid through the micro-channel so that a mesh comprising DNA is formed in the channel.

Abstract: The invention relates to a method for the stabilization, purification or/and isolation of nucleic acids from biological materials, in particular stool samples which may contain contaminations and interfering substances. Furthermore, a reagent kit suitable for carrying out the method of the invention is described.

Abstract: The purification of the E.coli K5 polysaccharide by treatment with isopropyl alcohol and elimination of lipophilic substances is described. The purified product can be used to prepare, after N-deacetylation, new N,O-sulfated polysaccharides with high degree of sulfation.

Abstract: The invention relates to a novel synthetic route for a group of ligands and to an improved catalyst containing the ligand. The invention also provides use of a ligand for inhibiting dye transfer.

Abstract: A method is provided in which 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetracyclo[5.5.0.05,903,11]-dodecane (CL-20 or HNIW) is crystallized to its ?-polymorph by an inverse precipitation technique. A dry CL-20 solvent solution containing an amount of CL-20 dissolved in a CL-20 solvent is prepared. The dry solvent solution is added to a crystallizer containing a CL-20 non-solvent to cause precipitation of epsilon polymorph CL-20 crystals by the inverse precipitation technique. The precipitated epsilon polymorph CL-20 crystals are separated from the non-solvent and the solvent.

Abstract: The invention relates to a novel process for preparing low-monomer-content trimers based on 2,4- and/or 2,6-diisocyanatotoluene (TDI). A catalytic trimerization is carried out in a mixture of from 20 to 80% by weight of a diisocyanate component containing at least 80% by weight of 2,4- and/or 2,6-diisocyanatotoluene, from 20 to 80% by weight of solvent, and 0–20% by weight of an alcohol component, and also phenolic catalysts containing dialkylamino-methyl groups. In the course of ongoing trimerization, in one or more steps, additional monomeric 2,v4-diisocyanatotoluene is metered in.

Abstract: A process for the preparation of a compound of the formula wherein the substituents are defined as in the specification.

Abstract: Corticotropin-releasing factor (CRF) antagonists having the formula wherein the dashed lines, A, B, D E, F, Z, G, R3, and R5 having the definitions set forth in the specification pharmaceutical compositions containing them.

Abstract: In its several embodiments, this invention discloses novel processes to prepare the compounds of formula II and formula IV:

Abstract: A method for the treatment of bacterial infections in humans and non-human mammals, which comprises inhibiting bacterial growth by administering to a subject an antibacterially effective dose of a compound of formula (I) or a pharmaceutically or veterinarily acceptable salt thereof:

Abstract: Provided is a method of hydrogenating the exocyclic double bond of a thiazolidinedione precursor in a method of making a thiazolidinedione antihyperglycemic, for example pioglitazone, including work-up steps to afford pure thiazolidinedione antihyperglycemic.

Abstract: Compounds of the general structural formula (I), and use of the compounds and salts and solvates thereof, as therapeutic agents.

Abstract: Sulfonylamino phenylacetamide derivatives of the general formula are disclosed. Pharmaceutical compositions containing the compounds and methods for their use are also disclosed. In certain embodiments, the compounds of the invention that, preferably: (1) bind with high affinity to ? opioid receptors; (2) display good opioid receptor selectivity of ? versus ? and ? versus ?; and (3) do not substantially inhibit cytochrome P450 enzymatic activity, in particular CYP2D6, CYP2C9 and CYP3A4.

Abstract: The present invention provides novel forms of atorvastatin designated Forms VI, VIII, IX, X, XI and XII and novel processes for their preparation as well as processes for preparing atorvastatin Forms I, II, IV, V and amorphous atorvastatin.

Abstract: This invention relates to a process for producing N-aryl-2-lactams and N-cycloalkyl-2-lactams by reductive amination of lactones with aryl amines utilizing a metal catalyst, which is optionally supported.

Abstract: Refined ethylene sulfite exhibits an excellent storage stability when used as a constituent of an electrolyte. A method of producing same has a step of reacting ethylene glycol and thionyl chloride to producing raw ethylene sulfite, a rectifying step for rectifying the raw ethylene sulfite, and a refining process for refining the raw ethylene sulfite or the rectified ethylene sulfite conducted before or after the rectifying step. The refining process is at least one process selected from the group consisting of a washing process, a dehydration process by total reflux distillation, a second rectifying process, and an absorbing process. Refined ethylene sulfite produced according to the method contains chloroethanol in an amount of not more than 1000 ppm.

Abstract: A novel monomer compound having a lactone moiety of the present invention can be converted into polymers usable as resist materials with excellent properties, etc., and an alcohol compound having a lactone moiety of the invention is useful as a material for the monomer compound. The compounds are represented by the following general formula [1]: wherein one of R1 and R2 represents a hydrogen atom, an acryloyl group, or a methacryloyl group, and the other represents an alkyl group; R3 and R4 independently represent a hydrogen atom or an alkyl group; R5 and R6 both represent a hydrogen atom or are combined to form a methylene chain that may have an alkyl group; and R7 and R8 independently represent a hydrogen atom or a methyl group.

Abstract: The present invention relates to a method for the preparation of citalopram by alkylation of a 1-(4-fluorophenyl)-1,3-dihydroisobenzofurane derivative.

Abstract: The invention concerns a method for sulphonylating a hydroxylated organic compound. The invention concerns in particular aliphatic hydroxylated compounds and more particularly those which comprise on their aliphatic chain, an electroattractive group. The method for sulphonylating a hydroxylated organic compound is characterised in that it consists in reacting said compound, with a sulphonylating agent, in the presence of a sufficient amount of a Lewis acid.

Abstract: Copper-containing thin films can be industrially advantageously formed by chemical vapor deposition using as the copper source a divalent copper complex bearing ?-diketonato ligands having silyl ether linkage. A representative example of the divalent copper complex is represented by the formula (I): wherein Z is hydrogen or alkyl; X is a group represented by the formula (I—I), in which Ra is alkylene, and each of Rb, Rc and Rd is alkyl; and Y is an alkyl group or a group represented by the formula (I—I), in which Ra is alkylene, and each of Rb, Rc and Rd is alkyl.

Abstract: The present invention relates to a process for preparing phosphites and their transition metal complexes and also to their use in catalytic processes.

Abstract: A single source precursor for depositing ternary I-III-VI2 chalcopyrite materials useful as semiconductors. The single source precursor has the I-III-VI2 stoichiometry “built into” a single precursor molecular structure which degrades on heating or pyrolysis to yield the desired I-III-VI2 ternary chalcopyrite. The single source precursors effectively degrade to yield the ternary chalcopyrite at low temperature, e.g. below 500° C., and are useful to deposit thin film ternary chalcopyrite layers via a spray CVD technique. The ternary single source precursors according to the invention can be used to provide nanocrystallite structures useful as quantum dots. A method of making the ternary single source precursors is also provided.

Abstract: A method is disclosed for the formation of metal chelates which are able to remain stable in high alkaline environments when compared to metal chelates produced from a reaction with amino acids. The method involves the reaction of sugars, amino groups, and metal components for a sufficient period of time and temperature in a water solution. Additionally, the stability of metal chelates can be enhanced by oxidation of the sugars with an oxidizing agent such as hydrogen peroxide which form an MRP which will react with the metal component to form a more stable metal chelate than if oxidation were not utilized.

Abstract: The invention relates to a method for producing racemic metallocene complexes by reacting bridged or non-bridged transition metal complexes with cyclopentadienyl derivatives of alkaline or alkaline earth metals and optionally, subsequently substituting the phenolate ligands.

Abstract: Sulfonic acid ester derivatives represented by the general formula (4) or (5) are produced by reacting an amino alcohol derivative represented by the general formula (1) or (2) with an organic sulfonyl halide represented by the general formula (3), in a mixed solvent composed of an aprotic organic solvent and water in the presence of a non-water-prohibiting inorganic base. This procedure can be carried out in a simple, easy, safe and economical manner while reducing the load on the environment. Wherein n represents an integer of 0 to 5, A represents a phenyl group, which may be substituted, R represents a methanesulfonyl, ethanesulfonyl, p-toluenesulfonyl or p-nitrobenzenesulfonyl group and X represents a chloride, bromine or iodine atom.

Abstract: A process is described for preparing 3-trifluoromethylphenyl 4-cyanobenzyl ketone by reacting a C1–C2-alkyl 3-trifluoromethylbenzoate with 4-tolunitrile in an aprotic polar solvent or an aprotic polar solvent mixture in the presence of at least an equimolar amount of a base which is selected from potassium alkoxides of primary C1–C4-alkanols.

Abstract: The invention refers to new alkylating di- and tripeptides based on a melphalan unit, and one or two additional amino acids or amino acid derivatives, which can be used in the treatment of carcinogenic diseases. Further, the invention refers to a pharmaceutical composition comprising the alkylating peptides of the invention.

Abstract: A process for the manufacture of iodopropynyl butylcarbamate (IPBC) is disclosed wherein the subject reaction is carried out in an aqueous solution of a suitable surfactant. The iodination reactant is metallic iodide salt which serves as a donor of I+ ions. The I+ ion is generated on an as needed basis, during the reaction sequence, hence the formation of undesirable isomers of IPBC are minimized. The process of this invention produces a highly purified IPBC having, preferably, a low moisture content (wet-cake). The IPBC produced by such a process is also disclosed herein.

Abstract: The invention includes a method of forming an alpha, beta-unsaturated compound. A carboxylic acid is mixed with an alpha-hydroxy acid or an alpha-hydroxy ester and is esterified to form an alpha-acyloxy derivative. The alpha-acyloxy derivative is transformed into an alpha, beta-unsaturated derivative. The invention additionally includes a process of forming an acrylate. Lactic acid or a lactic acid ester is reacted with a first portion of acetic acid in the presence of a first catalyst to produce the corresponding 2-acetoxy propionic acid or ester. A non-reacted portion of the acetic acid is recycled. The 2-acetoxy propionic acid or ester is transferred to a second vessel containing a second catalyst, and acetic acid is liberated from the 2-acetoxy propionic acid or ester to produce a corresponding acrylic acid or acrylate ester. The acid or ester is subsequently esterified by reaction with an alcohol to form a desired acrylate ester.

Abstract: A fluorine-containing cyclic ester is represented by the formula 1: wherein each R1 independently represents —H or —F, wherein R2 is one selected from the group consisting of —H, —F, —CF3, —OH, —COOH and —COOR4, where R4 is an alkyl group having a carbon atom number of 1–15, and wherein R3 is a substituent selected from the group consisting of —F, —CF3, and —R5C(CF3)2OR6, where R5 is one selected from the group consisting of CH2, C2H4, and OCH2, and R6 is H or an acid-labile protecting group.

Abstract: The subject-matter of the invention is the B form of ethyl [(7S)-7-[(2R)-2-(3-chlorophenyl)-2-hydroxyethylamino]-5,6,7,8-tetrahydronaphth-2-yloxy]acetate hydrochloride, of use as a medicament, which exhibits in particular the following physical characteristics: characteristic IR absorption peaks (cm?1): 2780, 2736, 1722, 1211; melting point: 129+/?2° C.; characteristic lines of the powder X-ray diffraction diagram (to within 0.1(2?)): 7.69, 9.83, 13.95, 16.58, 18.70, 20.40, 21.57, 23.40, 24.15 and 25.64. The product can be obtained by salification of the base or recrystallization of the salt from an alcohol.

Abstract: Formic acid and a carboxylic acid having at least two carbon atoms and/or derivatives thereof are prepared jointly by a process in which (a) a formic ester (I) is transesterified with a carboxylic acid having at least two carbon atoms (II) to form formic acid (III) and the corresponding carboxylic ester (IV); and (b) at least part of the carboxylic ester (IV) formed in step (a) is carbonylated to give the corresponding carboxylic anhydride (V).

Abstract: Trifluoroethanol can be isolated from organic liquids that are contaminated by trifluoroethanol by bringing the contaminated liquid into contact with a molecular sieve having a pore size ranging between 0.5 and 1.0 nm, e.g., with molecular sieve 13X. This enables, for example, trifluoroacetic acid trifluoroethyl esters, bis(trifluoroethyl)carbonate or trifluoroethyl esters of phosphoric, phosphonic or phosphinic acid to be purified.