Patents Issued in February 27, 2007
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Patent number: 7183220Abstract: A plasma etching method includes forming a polymer comprising carbon and a halogen over at least some internal surfaces of a plasma etch chamber. After forming the polymer, plasma etching is conducted using a gas which is effective to etch polymer from chamber internal surfaces. In one implementation, the gas has a hydrogen component effective to form a gaseous hydrogen halide from halogen liberated from the polymer. In one implementation, the gas comprises a carbon component effective to getter the halogen from the etched polymer. In another implementation, a plasma etching method includes positioning a semiconductor wafer on a wafer receiver within a plasma etch chamber. First plasma etching of material on the semiconductor wafer occurs with a gas comprising carbon and a halogen. A polymer comprising carbon and the halogen forms over at least some internal surfaces of the plasma etch chamber during the first plasma etching.Type: GrantFiled: October 2, 2000Date of Patent: February 27, 2007Assignee: Micron Technology, Inc.Inventors: Guy T. Blalock, David S. Becker, Kevin G. Donohoe
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Patent number: 7183221Abstract: Fabricating a semiconductor includes depositing a metal layer outwardly from a dielectric layer and forming a mask layer outwardly from a first portion of the metal layer. Atoms are incorporated into an exposed second portion of the metal layer to form a composition-altered portion of the metal layer. The mask layer is removed from the first portion of the metal layer and a barrier layer is deposited outwardly from the metal layer. A poly-Si layer is deposited outwardly from the barrier layer to form a semiconductor layer, where the barrier layer substantially prevents reaction of the metal layer with the poly-Si layer. The semiconductor layer is etched to form gate stacks, where each gate stack operates according to one of a plurality of work functions.Type: GrantFiled: November 6, 2003Date of Patent: February 27, 2007Assignee: Texas Instruments IncorporatedInventors: Mark R. Visokay, Luigi Colombo
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Patent number: 7183222Abstract: A dual damascene interconnect structure, produced using etch chemistry based on C2H2F4, includes (i) an etch stop layer of either undoped silicon oxide or doped silicon oxide, and (ii) dielectric layers both above and below the etch stop layer of the other (i.e., when the etch stop layer comprises undoped silicon oxide, the dielectric layers above and below the etch stop layer independently comprise a doped silicon oxide; and when the etch stop layer comprises doped silicon oxide, the dielectric layers above and below the etch stop layer independently comprise an undoped silicon oxide).Type: GrantFiled: January 28, 2004Date of Patent: February 27, 2007Assignee: Cypress Semiconductor CorporationInventor: Jianmin Qiao
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Patent number: 7183223Abstract: Methods are provided for forming contacts for a semiconductor device. The methods may include depositing various materials, such as polysilicon, nitride, oxide, and/or carbon materials, over the semiconductor device. The methods may also include forming a contact hole and filling the contact hole to form the contact for the semiconductor device.Type: GrantFiled: December 8, 2003Date of Patent: February 27, 2007Assignee: Advanced Micro Devices, Inc.Inventors: Cyrus E. Tabery, Srikanteswara Dakshina-Murthy, Chih-Yuh Yang, Bin Yu
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Patent number: 7183224Abstract: A method is invented for processing a thin-film head/semiconductor wafer. A layer of polymer is applied onto a wafer. A layer of dielectric material is added above the polymer layer. A layer of photoresist is added above the dielectric layer. The photoresist layer is patterned using a photolithography process. Exposed portions of the dielectric layer are removed. Exposed portions of the polymer layer are removed. Exposed portions of the wafer are removed. The polymer layer and any material thereabove is removed after hard bias/leads deposition.Type: GrantFiled: July 30, 2003Date of Patent: February 27, 2007Assignee: Hitachi Global Storage Technologies Netherlands B.V.Inventors: Kim Y. Lee, Chun-Ming Wang
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Patent number: 7183225Abstract: A method for fabricating a semiconductor device is disclosed. In the method, a buffer oxide film and a nitride film are formed on a semiconductor substrate in succession, an opening is formed in the nitride film and the buffer oxide film for exposing a field region of the semiconductor substrate, the expose semiconductor substrate is wet etched with dilute HF solution and irradiated with a UV beam to form a trench with rounded upper edges and lower corners. Then, an oxide film is gap filled in the trench, the oxide film is planarized, and the nitride film and the buffer oxide film are removed to expose an active region of the semiconductor substrate. The present invention can moderate field concentrations at the upper edges and lower corners of the trench, reduce a leakage current from the semiconductor device, and improve electrical characteristics and/or yield of the semiconductor device.Type: GrantFiled: December 28, 2004Date of Patent: February 27, 2007Assignee: Dongbu Electronics Co., Ltd.Inventor: Jung Gyun Song
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Patent number: 7183226Abstract: A method for use in manufacturing a semiconductor device includes forming a photoresist pattern on a substrate, performing first etching process in which an initial trench is formed using the photoresist pattern as a mask, and performing second distinct etching process to enlarge the initial trench. Thus, the initial trench can be formed using the photoresist pattern having a stable structure. Thereafter, the trench is enlarged using an etching solution having a composition based on the material in which the initial trench is formed, e.g., a silicon substrate or an insulation film. Therefore, a metal wiring, an isolation film or a contact can be formed in the enlarged trench to desired dimensions.Type: GrantFiled: September 30, 2003Date of Patent: February 27, 2007Assignee: Samsung Electronics Co., Ltd.Inventors: Sung-Bae Lee, Sang-Rok Hah, Hong-Seong Son
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Patent number: 7183227Abstract: High flows of low-mass fluent gases are used in an HDP-CVD process for gapfill deposition of a silicon oxide film. An enhanced turbomolecular pump that provides a large compression ratio for such low-mass fluent gases permits pressures to be maintained at relatively low levels in a substrate processing chamber, thereby improving the gapfill characteristics.Type: GrantFiled: July 1, 2004Date of Patent: February 27, 2007Assignee: Applied Materials, Inc.Inventors: Muhammad M. Rasheed, Steven H Kim
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Patent number: 7183228Abstract: Patterned growth of arrays of SWNTs is achieved at the full-wafer scale. According to an example embodiment of the present invention, the chemistry of CH4 CVD has been discovered to be sensitive to the concentration of H2, leading to three regimes of growth conditions. The three regimes are identified for particular growth conditions and a regime that facilitates carbon nanotube growth while inhibiting pyrolysis is identified and used during CVD growth of the nanotubes. This approach is also useful for CVD synthesis of other nanomaterials. In this manner, patterned growth of carbon nanotubes is facilitated while inhibiting undesirable conditions, making nanotube orientation control and device integration possible on a large scale.Type: GrantFiled: October 31, 2002Date of Patent: February 27, 2007Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Hongjie Dai, Nathan R. Franklin
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Patent number: 7183229Abstract: An object of the present invention is to provide a method for easily forming a polycrystalline semiconductor thin-film, such as polycrystalline silicon having high crystallinity and high quality, or a single crystalline semiconductor thin-film at inexpensive cost, the crystalline semiconductor thin-film having a large area, and to provide an apparatus for processing the method described above.Type: GrantFiled: December 7, 2001Date of Patent: February 27, 2007Assignee: Sony CorporationInventor: Hideo Yamanaka
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Patent number: 7183230Abstract: A protective cover system (100) for inhibiting corrosion of a metallic object. The protective cover system includes a cover (101, 200, 600) for defining a microenvironment and a corrosion inhibitor source for releasing one or more corrosion inhibitors into the microenvironment. In one embodiment, cover 200 comprises an outer liquid-impermeable layer (204), an inner liquid-permeable layer (202), and a superabsorbent layer (206) located between the outer and inner layers. In another embodiment, cover 600 includes a water-vapor-permeable layer (602) and a porous support layer (606) for supporting the water-vapor-permeable layer. In both of these embodiments, one or more corrosion inhibitors may be incorporated into the cover in one or more of the corresponding above-mentioned layers or in a layer separate from these layers, or may be provided in a separate container that fluidly communicates the corrosion inhibitor(s) to the microenvironment.Type: GrantFiled: July 15, 2004Date of Patent: February 27, 2007Assignee: Creare Inc.Inventors: Nabil A. Elkouh, Jeffrey J. Breedlove, Bruce R. Pilvelait
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Patent number: 7183231Abstract: The present invention is directed to a textile material comprising yarns wherein the material is textured by subjecting specified regions of the material to incremental strains sufficient to cause yarn failures or yarn elongation in yarns running in one direction within the specified regions. The yarns in a direction orthogonal to the direction of the failed or elongated yarns will generally have substantially unaltered physical properties and are redistributed within the specified regions. Typically, the yarn failures or elongation will be in the fill direction and yarns in the warp direction will have unaltered physical properties and be redistributed within the specified regions. Also included in the present invention is a method of manufacturing the textured textile material.Type: GrantFiled: November 7, 2002Date of Patent: February 27, 2007Assignee: The Procter & Gamble CompanyInventors: Jody Lynn Hoying, John Joseph Curro, Susan Nicole Lloyd, John Brian Strube
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Patent number: 7183232Abstract: Radio-opaque glass ceramics are described which have high chemical durability and adjustable translucency, brightness and coefficient of thermal expansion.Type: GrantFiled: September 1, 2004Date of Patent: February 27, 2007Assignee: Ivoclar Vivadent AGInventors: Christian van't Hoen, Elke Apel, Wolfram Höland, Volker M. Rheinberger
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Patent number: 7183233Abstract: Process for removal of the esterification catalyst by separation from a crude plasticizer ester obtained by reacting a dicarboxylic acid with C8–C13 alcohols, by treating the crude ester with an aqueous alkali solution in the range from 10 to 100° C. and then separating the aqueous alkaline phase comprising the hydrolyzed esterification catalyst by gravitational phase separation, by treating the crude ester, prior to or during the phase separation, with a salt of a di- or polyvalent metal, or with a mixture of these salts.Type: GrantFiled: July 23, 2003Date of Patent: February 27, 2007Assignee: BASF AktiengesellschaftInventors: Kurt Schwirten, Walter Disteldorf, Günther Golfier, Jarren Peters
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Patent number: 7183234Abstract: The present invention provides catalyst systems including a Ziegler-Natta or Ziegler-Natta-type catalyst in combination with a mixture of certain electron donors.Type: GrantFiled: April 29, 2004Date of Patent: February 27, 2007Assignee: ExxonMobil Chemical Patents Inc.Inventors: Robert Tan Li, Kevin Wayne Lawson, Aspy Keki Mehta, Prasadarao Meka
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Patent number: 7183235Abstract: The present invention is directed to a sorbent comprising a disordered polyvalent metal oxide on the surface of an inert substrate. The substrate can be a layered silicate, such as vermiculite, an aluminosilicate such as montmorillonite, or a nonlayered silicate such as a zeolite. The sorbent removes ionic contaminants, such as arsenic, from process streams.Type: GrantFiled: June 20, 2003Date of Patent: February 27, 2007Assignee: ADA Technologies, Inc.Inventors: John Stanley Lovell, Thomas E. Broderick, Craig S. Turchi, Amanda K. Kimball
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Patent number: 7183236Abstract: An object of the present invention is to realize low pressure loss and high purification performance in a constitution in which a primary catalyst component and co-catalyst component are loaded onto a ceramic support that allows catalyst components to be loaded directly. According to the present invention, a primary catalyst component in the form of a catalyst precious metal and a co-catalyst component in the form of an oxygen occluding component are loaded on the surface of a honeycomb-shaped ceramic support, including the inner surfaces of pores. As a result of the large loaded amount of co-catalyst component entering inside the pores, the loaded amount of co-catalyst component on the cell wall surfaces is reduced, thereby making it possible to inhibit increases in pressure loss. In addition, since the primary catalyst component and co-catalyst component are in close proximity to each other, catalyst performance is improved.Type: GrantFiled: August 5, 2003Date of Patent: February 27, 2007Assignee: Denso CorporationInventors: Tomomi Hase, Tomohiko Nakanishi, Hideaki Ueno, Takatoshi Shinyoshi
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Patent number: 7183237Abstract: A method of weed control using a biological paradigm. A method for the use of dried distiller's grain and soluble as an herbicide and a fertilizer in the use of crop production. A method for the processing of corn and other crops including the re-use of the dried grain by-products in subsequent crop production. A method for the production of grain alcohol including the re-use of the dried grain by-products in subsequent crop production.Type: GrantFiled: April 19, 2004Date of Patent: February 27, 2007Inventor: David Blume
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Patent number: 7183238Abstract: The present invention relates to novel [1,2]-oxazine-3,5-dione derivatives of the formula (I) in which W, X, Y, Z, G, D, A and B are as defined in the disclosure, to a plurality of processes for their preparation, and to their use as microbicides, pesticides and herbicides.Type: GrantFiled: November 27, 2002Date of Patent: February 27, 2007Assignee: Bayer CropScience AGInventors: Reiner Fischer, Thomas Schenke, Angelika Lubos-Erdelen, legal representative, Christoph Erdelen, deceased
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Patent number: 7183239Abstract: Coacervate gels having excellent shear viscosities and other properties are made with anionic or cationic polymers, a smaller amount of a surfactant having a charge opposite that of the polymer, and a hydrophobic alcohol. The Zeta Potential of the gel is maintained at an absolute value of at least 20. Optional gel promoting additives include betaines and amine oxides. A preferred gel comprises poly diallyl dimethyl ammonium chloride, a lesser amount of sodium lauryl sulfonate, and lauryl alcohol. The gels are particularly useful forming plugs and pigs for separating fluids in pipes.Type: GrantFiled: December 11, 2002Date of Patent: February 27, 2007Assignee: Clearwater International, LLCInventors: Kevin W. Smith, Kevin M. Schwartz
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Patent number: 7183240Abstract: The present invention relates to an additive, and its use for inhibiting nucleation, growth and agglomeration of gas hydrates by adding an effective amount of an inhibitor to a multiphasic mixture which tends to hydrate formation and consists of water, gas and optionally condensate, or to a drilling fluid which tends to form gas hydrates. Said inhibitor comprising dialkoxylated quaternary ammonium compounds of the formula 1 where R1, R2 are each independently radicals of the formulae—(B)—(O—A)n—O—CO—R5 or —(A—O)n—(C)—CO—O—R5, R3 is C1- to C30-alkyl or C2- to C30-alkenyl, R4 is an organic radical which optionally contains heteroatoms and has from 1 to 100 carbon atoms, R5 is an alkyl or an alkenyl, n is a number from 1 to 20, A is an alkylene group, B is an alkylene group, C is a C1- to C6-alkylene group and X is an anion, are used as gas hydrate inhibitors.Type: GrantFiled: June 27, 2002Date of Patent: February 27, 2007Assignee: Clariant Produkte (Deutschland) GmbHInventors: Uwe Dahlmann, Michael Feustel
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Patent number: 7183241Abstract: A lubricating oil with very low phosphorus content, and having long life as evidenced by a reduction in viscosity increase, oxidation and nitration, comprises a major amount of a base oil of lubricating viscosity and a minor amount of a mixture of neutral and overbased metallic detergents, at least a zinc dialkyldithiocarbamate and a zinc dialkyldithiophosphate antiwear additive and at least a dihydrocarbylthiocarbamoyl.Type: GrantFiled: September 19, 2003Date of Patent: February 27, 2007Assignee: ExxonMobil Research and Engineering CompanyInventor: Stanley James Cartwright
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Patent number: 7183242Abstract: The present invention provides a lubricant system in the pressing of powders to form a part. The lubricant system is a solid at ambient conditions. However, upon application of pressure during the pressing of the metal parts, the lubricant system forms a liquid phase along the walls of cavity in which the powder is being pressed.Type: GrantFiled: November 24, 2003Date of Patent: February 27, 2007Assignee: Apex Advanced Technologies, LLCInventor: Dennis L. Hammond
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Patent number: 7183243Abstract: Hair washing compositions are disclosed which comprise cleansing surfactant, water, first and second cationic polymers having at pH7 a charge density from 0.2 to 1 meq/gm and from 1.3 to 3 meq/gm respectively, and droplets of a water-insoluble conditioning oil of diameter 4 micrometres or less. The compositions provide cleansing with conditioning and low friction and ease of combing for wet and dry hair.Type: GrantFiled: October 30, 2003Date of Patent: February 27, 2007Assignee: Unilever Home & Personal Care USA division of Conopco, Inc.Inventors: Nicholas John Ainger, Anand Ramchandra Mahadeshwar, Neil Scott Shaw
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Patent number: 7183244Abstract: Provided is a detergent composition having components (A) and (B1): (A) a phosphate monoester (1), and (B1) a phosphate monoester (2), wherein n=1; components (A), (B1) and (B2): (A) a phosphate monoester (1), (B1) a phosphate monoester (2), wherein n=1, and (B2) a phosphate monoester (2), wherein n=2; components (A), (B1) and (B2): (A) a phosphate monoester (1), (B1) a phosphate monoester (2), wherein n=1, and (B2) a phosphate monoester (2), wherein n=2; components (A) and (C): (A) a phosphate monoester (1), and (C) a phosphate monoester (3); or a phosphate-based surfactant produced by reacting a compound obtained by adding to an alcohol an alkylene oxide of 2 to 4 carbon atoms, with phosphoric acid, a polyphosphoric acid or P2O5: The detergent composition is mild to the skin, is high in versatility, and has a good foaming property in weak acidic water or in hard water.Type: GrantFiled: December 22, 2004Date of Patent: February 27, 2007Assignee: Kao CorporationInventors: Yoshinori Tamura, Ryosuke Fujii, Tomoko Uchiyama
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Patent number: 7183245Abstract: A chemical stripping solvent composition is provided for removing cured polymeric isoprene and bisbenzocyclobutene (BCB) substances from an inorganic substrate. The stripping composition comprises about 20 to about 30 weight percent anisole, about 20 to about 30 weight percent mesitylene, about 35 to about 55 weight percent of an alkylbenzene sulfonic acid, and may contain methane sulfonic acid (MSA) at 3 to about 10 weight percent, added to remove BCB in the full-cured state. Also provided is a method for stripping cured polymeric organic substances by contacting the polymeric organic substance with the stripping solvent composition at a given temperature and for a period of time sufficient to essentially dissolve and remove cured polymeric substances.Type: GrantFiled: December 23, 2003Date of Patent: February 27, 2007Assignee: General Chemical Performance Products, LLCInventor: John C. Moore
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Patent number: 7183246Abstract: A composition and method for cleaning surfaces having deposits, such as drink water tanks, supply water wells, water filter systems, and distributor water lines. The composition contains in combination a cleaning solution and a disinfectant, such as hydrogen peroxide or peracidic acid. The cleaning solution can includes hydrochloric acid and/or phosphoric acid in combination with inhibitors, dyes and water. The composition is applied to deposits which have formed on these surfaces.Type: GrantFiled: October 29, 2001Date of Patent: February 27, 2007Assignee: Floran Technologies Inc.Inventors: Jeffrey Schulhoff, Christian Schaal
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Patent number: 7183247Abstract: A process for the production of a flowable suspension containing phthalimidoperoxyhexanoic acid by combining phthalimidoperoxyhexanoic acid in granular form with a liquid alcohol and grinding the combination to form a flowable suspension of the phthalimidoperoxyhexanoic acid in the alcohol.Type: GrantFiled: June 13, 2005Date of Patent: February 27, 2007Assignee: Henkel Kommanditgesellschaft auf Aktien (Henkel KGaA)Inventors: Matthias Sunder, Christian Schoth, Theodor Voelkel, Dieter Nickel
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Patent number: 7183248Abstract: The present invention is directed to a cleaning composition comprising: (a) an enzyme in an amount effective to promote cleaning; (b) viable microorganisms in an amount effective to degrade and promote the degradation of organic materials; (c) a surfactant; and (d) an aqueous carrier; said cleaning composition maintaining at least 95% enzymatic activity at a pH range of from about 5.5 to about 13.5.Type: GrantFiled: August 20, 2002Date of Patent: February 27, 2007Assignee: Treyco Supply Co.Inventor: James T. Manning, Jr.
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Patent number: 7183249Abstract: A dry fragrance composition having from about 0.1 to about 20%, by total carrier weight, of a fragrance composition substantially uniformly deposited on the surface of a nonabsorbent solid inorganic particulate substrate is used to impart a fragrance to a second material. The nonabsorbent solid inorganic particulate substrate can be an alkali metal chloride, sulfates, or tripolyphosphates, soda ash, borax, or a zeolite.Type: GrantFiled: June 14, 2002Date of Patent: February 27, 2007Assignee: Robertet Fragrances, Inc.Inventor: Stephen V. Dente
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Patent number: 7183250Abstract: The present invention is related to a concentrated surfactant composition containing a hydrophobically modified polymer and/or a hydrotrope. The addition of the polymer or hydrotrope to the concentrated surfactant changes the physical properties of the concentrated surfactant, making it easier to process.Type: GrantFiled: June 17, 2003Date of Patent: February 27, 2007Assignee: National Starch and Chemical Investment Holding CorporationInventors: Klein A. Rodrigues, Kevin Beairsto
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Patent number: 7183251Abstract: This invention relates to the field of cancer therapy. More particularly, the invention relates to the treatment of mammary tumor, clinically manifest mammary tumor (breast cancer) and metastatic mammary tumor by administration of human Chorionic Gonadotropin (hCG). The treatment preferably comprises the administration of hCG in conjunction with an antiestrogen and/or a Type I Interferon.Type: GrantFiled: December 15, 1999Date of Patent: February 27, 2007Assignees: Fox Chase Cancer Center, Applied Research Systems ARS Holdings N.V.Inventors: Irma H. Russo, Jose Russo, Giampiero Deluca, Jaak Janssens
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Patent number: 7183252Abstract: The invention is directed to novel indole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.Type: GrantFiled: March 31, 2003Date of Patent: February 27, 2007Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Han-Cheng Zhang, William J. Hoekstra, Bruce E. Maryanoff, David F. McComsey
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Patent number: 7183253Abstract: The invention provides new substantially pure antibiotics designated AC-98-1, AC-98-2, AC-98-3, AC-98-4 and AC-98-5 derived from the microorganism Streptomyces hygroscopicus.Type: GrantFiled: February 4, 2004Date of Patent: February 27, 2007Assignee: Wyeth Holdings Corp.Inventors: Guy Thomas Carter, Haiyin He
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Patent number: 7183254Abstract: Leptin, leptin analogs, and leptin derivatives are used to treat patients with lipoatrophy. Leptin is effective against conditions of lipoatrophy for both genetic and acquired forms of the disease. A therapeutically effective amount of leptin can be administered in a variety of ways, including subcutaneously and using gene therapy methods. Methods of the present invention contemplate administration of leptin, leptin analogs, and leptin derivatives to patients having a leptin level of approximately 4 ng/ml or less before treatment.Type: GrantFiled: July 18, 2003Date of Patent: February 27, 2007Assignee: Amgen, Inc.Inventors: Alexander M. DePaoli, Simeon I. Taylor, Elif A. Oral, Abhimanyu Garg
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Patent number: 7183255Abstract: The present invention provides a method for regulating blood pressure in a hemodialysis subject using a vasopressin receptor agonist, so as to facilitate removal of excessive extracellular fluid in the subject.Type: GrantFiled: February 26, 2004Date of Patent: February 27, 2007Assignee: Intradialytic PharmaceuticalsInventors: Donald W. Landry, Juan A. Oliver
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Patent number: 7183256Abstract: Polypeptides or proteins comprising tissue inhibitor of mettaloproteinases-3 (TIMP3) or variants of TIMP3 can be used to substantially inhibit vascular endothelial growth factor (VEGF) binding to VEGF recptor-2 (VEGFR2/KDR/Flk-1)) without substantially inhibiting VEGF binding to VEGF receptor 1 (VEGFR1/Flt-1).Type: GrantFiled: March 19, 2004Date of Patent: February 27, 2007Assignee: Cleveland Clinic FoundationInventor: Bela Anand-Apte
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Patent number: 7183257Abstract: The present invention relates to peptides of RPL41 and their use in the treatment of cancer and microbial infections. It is contemplated that modified forms of RPL41, including substitutional variants and mimetics, will be used. Mono- and combination therapies with other cancer treatments are contemplated.Type: GrantFiled: April 13, 2005Date of Patent: February 27, 2007Assignee: The Brigham and Women's Hospital, Inc.Inventor: Sheng Xiao
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Patent number: 7183258Abstract: Two synthetic peptides, Atroporin (AT) and Kaotree (KT), each consisting of ten amino acids and their use for the treatment and/or prevention of various types of cancers is disclosed. The amino acid sequence from the N-terminal for AT is Phe-Cys-Arg-Phe-Leu-Leu-Cys-Pro-Ser-Arg, and for KT is Pro-Pro-Gly-Asn-Gln-Pro-Asp-Ala-Asp-Ser.Type: GrantFiled: June 19, 2002Date of Patent: February 27, 2007Inventors: Binie V. Lipps, Frederick W. Lipps
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Patent number: 7183259Abstract: This invention is directed to compounds that provide for sustained systemic concentrations of GABA analogs following administration to animals. This invention is also directed to pharmaceutical compositions including and methods using such compounds.Type: GrantFiled: May 13, 2003Date of Patent: February 27, 2007Assignee: XenoPortInventors: Randall A. Scheuerman, Mark A. Gallop, Kenneth C. Cundy, Ronald W. Barrett
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Patent number: 7183260Abstract: This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.Type: GrantFiled: August 25, 2004Date of Patent: February 27, 2007Assignee: Idun Pharmaceuticals, Inc.Inventors: Donald S Karanewsky, Robert J Ternansky, Steven D Linton, Thang Dinh
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Patent number: 7183261Abstract: Galactosylceramide analogues represented by the following formula (1) or (2). (wherein X and Y each represent S or O, R1 and R2 each represent an alkyl group or an alkenyl group each having 9 to 35 carbon atoms. R3 represents an alkyl group or an alkenyl group each having 2 to 30 carbon atoms.) It is provided a ?-glucocerebrosidase activator which is easily available, and external skin preparations and a method of activating ?-glucocerebrosidase, in which improvement in formation of horny layer transmission barrier is expected by activating ?-glucocerebrosidase so that an improved effect in rough skin is also expected.Type: GrantFiled: June 27, 2002Date of Patent: February 27, 2007Assignee: Kao CorporationInventors: Rie Uematsu, Fumio Nakajima, Masahiro Yoshida, Kyoko Fukunaga, Mariko Hara, Shintaro Inoue, Shinichiro Nishimura
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Patent number: 7183262Abstract: A method for controlling in vivo heat-inducible gene expression for provision of therapeutic polypeptide. The method includes the steps of: (a) providing a construct comprising a polynucleotide encoding a therapeutic polypeptide, wherein the polynucleotide is operatively linked to a heat-inducible promoter; (b) administering the construct to a warm-blooded vertebrate at a site at or near the tumor; and (c) applying heat to the site at or near the tumor to express the therapeutic polypeptide, whereby anti-tumor activity is observed.Type: GrantFiled: June 14, 2002Date of Patent: February 27, 2007Assignee: Duke UniversityInventors: Chuan-Yuan Li, Qian Huang, Mark W. Dewhirst
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Patent number: 7183263Abstract: Linear polyethylenimine was modified with sterols, such as cholesterol, in three different geometries: linear shaped (L), T-shaped (T), and a combined linear- and T-shaped (LT), to result in linear polyethylenimine-sterol conjugates. These conjugates were mixed with nucleic acids to form complexes for delivery of the nucleic acids into cells. Mammalian cells transfected with these complexes showed protein expression levels higher than linear polyethylenimine alone, and twice that of branched polyethylenimine, but without any significant loss in cell viability. Methods of making these compositions and methods of using them for gene delivery are also described.Type: GrantFiled: July 17, 2003Date of Patent: February 27, 2007Assignee: University of Utah Research FoundationInventors: Darin Y. Furgeson, Sung Wan Kim
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Patent number: 7183264Abstract: 2-adenosine N-pyrazole compounds having the following formula: and methods for using the compounds as A2A receptor agonists to stimulate mammalian coronary vasodilatation for therapeutic purposes and for purposes of imaging the heart are disclosed.Type: GrantFiled: August 29, 2003Date of Patent: February 27, 2007Assignee: CV Therapeutics, Inc.Inventors: Jeff Zablocki, Elfatih O. Elzein, Venkata P. Palle, Luiz Belardinelli
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Patent number: 7183265Abstract: The object of the present invention is to provide a powdery product comprising crystalline ?-maltose monohydrate which is powderized by spray method, and has a high-solubility in aqueous solvents and a satisfactory handleability, and to its preparation and uses.Type: GrantFiled: May 20, 2005Date of Patent: February 27, 2007Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Takashi Shibuya, Toshiyuki Sugimoto, Toshio Miyake
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Patent number: 7183266Abstract: The present invention relates generally to a method of blunting the postprandial glycemic response to a meal by feeding a dual induced viscosity fiber system. The first component of the induced viscosity fiber system is soluble fiber. The second component of the induced viscosity fiber system is water-insoluble, acid-soluble multivalent cations. The third component of the induced viscosity fiber system in lightly hydrolyzed starch. The fiber system will typically be incorporated into a meal replacement nutritional. The present invention also refers to a method of delivering soluble fiber to diabetics and to persons needing to lose weight. Additionally, the invention refers to a method of promoting the feeling of fullness and satiety by feeding a nutritional product containing the induced viscosity fiber system.Type: GrantFiled: May 29, 2002Date of Patent: February 27, 2007Assignee: Abbott LaboratoriesInventors: Bryan W. Wolf, Bruce B. Blidner, Keith A. Garleb, Chron-Si Lai, Timothy W. Schenz
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Patent number: 7183267Abstract: The invention provides novel non-?-lactam inhibitors of ?-lactamases. In particular, the invention provides boronic acid-based compounds set forth in the specification. These compounds may be used with ?-lactam antibiotics to bacterial infection, particularly, ?-lactam-antibiotic-resistant bacterial infections. These compounds are also antibacterial agents by themselves. The invention further provides methods of using such compounds. Finally, the invention provides a pharmaceutical composition comprising these compounds.Type: GrantFiled: June 10, 2004Date of Patent: February 27, 2007Assignees: The Johns Hopkins University, Fulcrum Pharmaceuticals Inc.Inventors: Ernesto Freire, Patrick Ross, Yingxin Xiao, Raphael Ottenbrite, Irene Luque
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Patent number: 7183268Abstract: Compounds which are active against viruses have the following Formulas: wherein B is 2-aminopurine-9-yl, which may be unsubstituted or substituted in the 6 position with NHR1, OR2, or SR3; R1 is selected from the group consisting of alkyl, alkenyl, alkynyl, and C4-18 cycloalkyl, any of which may be optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl and aryl; R2 is selected from the group consisting of C2-18 alkyl, alkenyl, alkynyl, and cycloalkyl, any of which may be branched or unbranched and optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl, and aryl; and R3 is selected from the group consisting of alkyl, alkenyl, alkynyl, and cycloalkyl, any of which may be branched or unbranched and optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl and aryl.Type: GrantFiled: September 15, 2004Date of Patent: February 27, 2007Assignees: Wayne State University, The Regents of the University of MichiganInventors: Jiri Zemlicka, John C. Drach, Xinchao Chen
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Patent number: 7183269Abstract: According to the invention, compositions are made available which have a strong cytotoxic effect which is largely selective on tumor tissue. The invention is based on the fact that certain benzoic acid derivatives have a strong synergistic effect as a mixture and destroy cancer cells selectively in a pH range of 7 or below, such as from 6.5 to 7.Type: GrantFiled: November 17, 2003Date of Patent: February 27, 2007Inventor: Werner Kreutz