Patents Issued in April 12, 2007
  • Publication number: 20070082319
    Abstract: Provided is a jaw retention device and a corresponding method for retaining an individual's jaw in an open position during dental procedures. In its various embodiments, the device incorporates a mouthpiece and a handhold object which are interconnected by an elongate member. Both the handhold object and the mouthpiece may be moveably disposed about respective first and second end portions of the elongate member to allow the device to be selectively oriented as desired during use.
    Type: Application
    Filed: October 12, 2005
    Publication date: April 12, 2007
    Applicant: HYT SYSTEM, LLC
    Inventors: Thomas Fletcher, Paul Fletcher
  • Publication number: 20070082320
    Abstract: The prosthesis includes, initially, an implant and an angled abutment's stump that is affixed to the implant by threading devices, to which a dental prosthetic piece is then attached. The invention is characterized in that the threading means include a threaded lower piece (4) matched to the angled abutment's stump (6), in which the angled piece (4) and the abutment form one whole piece (5). In this manner unthreading the abutment piece is prevented and the prosthetic dental piece (8) abuts an adjacent dental piece since said unthreading action requires making eccentric circular motions. A special key that couples the angled abutment is intended to effect the turning motion required to tighten the abutment. In addition the invention entails two sets of abutments, each one comprising similar abutments that differ in a slight variation or offset at the beginning of the thread intended to achieve the desired tilt of the abutment.
    Type: Application
    Filed: May 26, 2006
    Publication date: April 12, 2007
    Inventor: Vicente Faus Badia
  • Publication number: 20070082321
    Abstract: The invention relates to a method for manufacturing implant abutments 9 for dental implants 1, wherein the implant abutment 9 comprises a prefabricated base member 8 for joining the implant abutment to the dental implant 1, and a customized main body 15. The aim of the invention is to simplify this method of manufacturing. To this end, the main body 15 is formed by sintering and/or melting powdery material onto the base member 8 using laser sintering and/or laser melting. The invention relates also to an implant abutment manufactured by such a method.
    Type: Application
    Filed: December 7, 2006
    Publication date: April 12, 2007
    Inventors: Ingo Uckelmann, Helmut Laschutza
  • Publication number: 20070082322
    Abstract: The present invention relates to training simulators for sharp shooting and introduces a number of functionalities that provide significant savings and further efficiencies such as usage of actual unmodified combat firearms for training purposes, simultaneous training of two individual shooters with individual identification and result display of the firing activity from each shooter on a computer generated concentrical target analogous to the ones used today in firearm training facilities, as well as the usage of a specialized weapon trigger contactor which is mounted on the actual weapon and that provides the usage functionalities to allow training on all single, and double action pistols as well as fully automatic weapons. The simulator also incorporates an emitting unit consisting of a laser light diode and the associated mounting mechanisms which allow the mounting of the emitting unit on any standard firearm.
    Type: Application
    Filed: October 12, 2005
    Publication date: April 12, 2007
    Inventor: Matvey Lvovskiy
  • Publication number: 20070082323
    Abstract: Orders such as a chronological order of historical eras and orders of importance in cultural values of artworks exhibited in a museum are displayed by using the colors of the rainbow.
    Type: Application
    Filed: July 2, 2004
    Publication date: April 12, 2007
    Inventor: Jiro Nishi
  • Publication number: 20070082324
    Abstract: Providing an interactive environment that requires a user to exercise one or more social skills to achieve a goal, and generating a simulation progress report indicative of the success of the user's exercise of the social skills during the interactive social simulation in a plurality of separate categories that are each related to the one or more social skills based on the user's interaction with the interactive environment.
    Type: Application
    Filed: October 18, 2006
    Publication date: April 12, 2007
    Inventors: W. Johnson, Hannes Vilhjalmsson, Andre Valente, Prasan Samtani, Ning Wang
  • Publication number: 20070082325
    Abstract: A device (20) and method for training a golfer's swing by synchronizing the movements of their club (40) to prompts produced by a microprocessor (48) that has been scientifically programmed with the tempo of the Tour Pros. Once it has been determined what the optimum tempo for that particular golfer is, then fitting the golfer to a shaft (36) that has the proper matrix development to complement the optimum flexing and straightening of the shaft to the golfer's tempo. The device (20) is also programmed for use with putting and short game tempos, which are different than those used for full shots.
    Type: Application
    Filed: October 10, 2006
    Publication date: April 12, 2007
    Inventor: John Novosel
  • Publication number: 20070082326
    Abstract: A foldable stand that accommodates and supports multiple types of handheld devices, a means of clamping these devices in place to enable manipulation of the device's user interface, a camera for capturing a real-time video image of the handheld device's display, and a means of transmitting this image to a computer.
    Type: Application
    Filed: October 7, 2006
    Publication date: April 12, 2007
    Inventors: Matthew Nuffort, Jeffrey Hunt
  • Publication number: 20070082327
    Abstract: Phenotypes and the cells that exhibit those phenotypes are described. The phenotype may be established as a “snapshot” of the cells at a particular time or it may be established as a variation in features over time, or as some combination of these “static” and “dynamic” characterizations. The phenotype may be characterized by at least the following features: mitotic arrest characterized (i) chromosomes well-aligned at the metaphase plate and (ii) chromosome residence time at the metaphase plate substantially longer than that of a control cell or cell population. The phenotype may be further characterized by: during interphase the cell or population of cells exhibits a phenotype that is substantially similar to that of the interphase cells of the control cell or cell population.
    Type: Application
    Filed: September 8, 2006
    Publication date: April 12, 2007
    Inventors: Cynthia Adams, Reginald de la Rosa, Shyamlal Ramchandani, Penelope Chua
  • Publication number: 20070082328
    Abstract: A rotatable time varying electromagnetic force bioreactor comprising a culture chamber having an interior portion that removably receives a cell mixture and an exterior portion with an electrically conductive coil wrapped around the exterior portion, a motor for rotating the culture chamber, and a time varying electromagnetic force source operatively connected to the electrically conductive coil. In use, the time varying electromagnetic force source delivers a time varying electromagnetic force to the interior portion of the culture chamber exposing the mammalian cells therein to a time varying electromagnetic force thereby expanding the mammalian cells.
    Type: Application
    Filed: September 26, 2006
    Publication date: April 12, 2007
    Inventor: DONNIE RUDD
  • Publication number: 20070082329
    Abstract: A method for assessing fertility for a couple that includes obtaining semen analysis results from a male member of the couple, obtaining fertility survey responses from at least a female member of the couple, determining an initial location in a diagnostic matrix using the semen analysis results and the fertility survey responses, and obtaining a plurality of treatment options corresponding to the initial location in the diagnostic matrix.
    Type: Application
    Filed: October 6, 2006
    Publication date: April 12, 2007
    Applicant: Pathways to Pregnancy LP
    Inventors: Russel Williams, Rakesh Mangal, David Nienberg, David Stump, Daniel Sharber
  • Publication number: 20070082330
    Abstract: Icosahedral phage and collections thereof that display various compounds are provided. In some instances, the icosahedral phage include nucleic acid tags that serve to record a characteristic of the compound or compounds that are attached to the phage. A number of different methods for using the icosahedral phage to screen a library of compounds for a desired biological activity are also provided, especially assays for compounds that are substrates for receptor-mediated transport processes such as endocytosis and transcytosis.
    Type: Application
    Filed: March 21, 2002
    Publication date: April 12, 2007
    Applicant: XenoPort, Inc.
    Inventors: Ronald Barrett, William Dower, Mark Gallop, Thomas Woiwode, Steven Cwirla
  • Publication number: 20070082331
    Abstract: A cartridge capable of making effective use of a sample is provided. A blood sample is injected into a well via an injection path by use of a syringe, and so forth. A roller, in a state as kept pressed into contact with the cartridge, is rotated rightward, whereupon an elastic member undergoes elastic deformation to cause the blood sample held in the well, and a liquid solvent held in a well to reach a well, and the blood sample is thereby mixed with the liquid solvent. Since the liquid solvent contains surfactant, blood cells are destroyed in the well. The liquid solvent reaches a well via a flow path. At this point in time, magnetic particles held in the well, and a cleaning liquid held in the well are merged with the mixed liquid in the well. A magnet is shifted from a position corresponding to the well to a position corresponding to the well along the flow path, thereby separating and transferring DNA caught by the magnetic particles to the well.
    Type: Application
    Filed: October 5, 2006
    Publication date: April 12, 2007
    Applicant: YOKOGAWA ELECTRIC CORPORATION
    Inventors: Takeo Tanaami, Hidetoshi Aoki
  • Publication number: 20070082332
    Abstract: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
    Type: Application
    Filed: January 8, 2003
    Publication date: April 12, 2007
    Inventors: Donna Mendrick, Mark Porter, Kory Johnson, Brandon Higgs, Arthur Castle, Michael Elashoff
  • Publication number: 20070082333
    Abstract: The present invention provides compositions comprising thermostable DNA polymerases derived from hyperthermophilic eubacteria. In particular, the present invention comprises thermostable DNA polymerases from the hyperthermophilic eubacterial species Thermoactinomyces vulgaris. The present invention also provides methods for utilizing naturally-occurring and non-naturally-occurring forms of T. vulgaris DNA polymerase in sequencing, reverse transcription, and amplification reactions.
    Type: Application
    Filed: May 23, 2003
    Publication date: April 12, 2007
    Inventors: Trent Gu, Fen Huang, James Hartnett
  • Publication number: 20070082334
    Abstract: A nucleic acid sequence encoding Mammastatin, a specific mammary cell growth inhibitor. Mammastatin is encoded by a single nucleic acid sequence and has an approximate molecular weight of 44 kDa in its inactive, non-phosphorylated form. Normal mammary cells express functional phosphorylated forms having approximate molecular weights of 53 kDa and 49 kDa. Metastatic mammary cells either do not express Mammastatin at all, or do not express the 53 kDa or 49 kDa, phosphorylated forms. Mammary cancer cells are inhibited in their growth by the administration of phosphorylated mammastatin.
    Type: Application
    Filed: June 11, 2003
    Publication date: April 12, 2007
    Inventor: Paul Ervin
  • Publication number: 20070082335
    Abstract: The invention provides methods and compositions based on the interaction of TSG101 and VPS28 proteins for treatment of viral infections, including HIV infections. The invention also provides TSG101-VPS28 based methods and compositions for evaluation and screening of drugs which can be used for treating viral infections.
    Type: Application
    Filed: February 12, 2004
    Publication date: April 12, 2007
    Inventors: Xiao-Fang Yu, Bindong Liu, Limin Li
  • Publication number: 20070082336
    Abstract: A method for labeling acyl carrier protein (ACP) fusion proteins with a wide variety of different labels is disclosed. The method relies on the transfer of a label from a coenzyme A type substrate to an ACP fusion protein using a holo-acyl carrier protein synthase (ACPS) or a homologue thereof. The method allows detecting and manipulating the fusion protein, both in vitro and in vivo, by attaching molecules to the fusion proteins that introduce a new physical or chemical property to the fusion protein. Examples of such labels are, among others, spectroscopic probes or reporter molecules, affinity tags, molecules generating reactive radicals, cross-linkers, ligands mediating protein-protein interactions or molecules suitable for the immobilization of the fusion protein.
    Type: Application
    Filed: May 19, 2004
    Publication date: April 12, 2007
    Applicant: EPFL-ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
    Inventors: Kai Johnsson, Nathalie George
  • Publication number: 20070082337
    Abstract: A method of identifying alternatively spliced exons is provided. The method comprising, scoring each of a plurality of exon sequences derived from genes of a species according to at least one sequence parameter, wherein exon sequences of the plurality of exon sequences scoring above a predetermined threshold represent alternatively spliced exons, thereby identifying the alternatively spliced exons.
    Type: Application
    Filed: January 27, 2005
    Publication date: April 12, 2007
    Applicant: Compugen Ltd.
    Inventors: Rotem Sorek, Sarah Pollock, Alex Diber, Zurit Levine, Sergey Nemzer, Guy Kol, Assaf Wool, Ami Haviv, Yuval Cohen, Yossi Cohen, Ronen Shemesh, Kinneret Savitsky
  • Publication number: 20070082338
    Abstract: Methods, systems and computer readable media for characterizing quality of CGH arrays, including generating at least one metric for a CGH array that characterizes a property of the CGH array; repeating generation of the at least one metric for at least one additional CGH array; and comparing each metric across all CGH array metric values generated to identify a quality of any one of the CGH arrays characterized, relative to the CGH arrays characterized for that metric. Methods, systems and computer readable media for determining the quality of a CGH array, including calculating a spread of the derivative of log ratio value differences between consecutive probes representing consecutive positions along a chromosome, wherein ratio values are calculated from probe signals from a CGH array, as read by a reader on first and second channels thereof, or from probes signals from two CGH arrays, as read by a single channel reader.
    Type: Application
    Filed: July 29, 2005
    Publication date: April 12, 2007
    Inventors: Bo Curry, Jayati Ghosh
  • Publication number: 20070082339
    Abstract: The invention relates to the use of gene and protein expression levels as a marker for HDAC inhibition. Also disclosed are in vivo and in vitro methods for screening a compound for HDAC inhibitory activity, as well as methods for monitoring the therapeutic efficacy of an HDAC inhibitor in a subject in vivo and for determining resistance to an HDAC inhibitor in vitro or in vivo.
    Type: Application
    Filed: October 7, 2005
    Publication date: April 12, 2007
    Inventors: Dalia Cohen, Shaowen Wang
  • Publication number: 20070082340
    Abstract: Described herein are novel SCCmec right extremity junction (MREJ) sequences for the detection and/or identification of methicillin-resistant Staphylococcus aureus (MRSA). Disclosed are methods and compositions based on DNA sequences for the specific detection of MREJ sequences designated types xi, xii, xiii, xiv, xv, xvi, xvii, xviii, xix, and xx for diagnostic purposes and/or epidemiological typing.
    Type: Application
    Filed: October 11, 2005
    Publication date: April 12, 2007
    Inventors: Ann Huletsky, Richard Giroux
  • Publication number: 20070082341
    Abstract: The invention provides human lipid metabolism enzymes (LME) and polynucleotides which identify and encode LME. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of LME.
    Type: Application
    Filed: January 18, 2006
    Publication date: April 12, 2007
    Inventors: Preeti Lal, Monique Yao, Henry Yue, Ameena Gandhi, Y. Tang, Farrah Khan, Danniel Nguyen, Jennifer Policky, Debopriya Das, Jennifer Hillman, Narinder Walia, April Hafalia, Catherine Tribouley
  • Publication number: 20070082342
    Abstract: In certain embodiments, an apparatus for analyzing the composition of bodily fluid includes a first fluid passageway having a patient end which is configured to provide fluid communication with a bodily fluid within a patient. The apparatus further includes at least one pump coupled to the first fluid passageway. The at least one pump has an infusion mode in which the pump is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further includes an analyte detection system accessible via the first fluid passageway such that the analyte detection system can receive at least one component of the drawn sample of bodily fluid and determine a concentration of at least one analyte. The analyte detection system is spaced from the patient end of the first fluid passageway.
    Type: Application
    Filed: December 21, 2005
    Publication date: April 12, 2007
    Inventors: James Braig, Kenneth Witte, Mark Wechsler, Peter Rule, Richard Keenan
  • Publication number: 20070082343
    Abstract: The invention relates to a new method for the control of enzymatic duplication of nucleic acids by the section via incomplete complementary strands. Fields of application of the invention are research, medical practice, gene-based analytics of biotechnological, agricultural and foodstuff products as well as criminology.
    Type: Application
    Filed: February 21, 2006
    Publication date: April 12, 2007
    Inventors: Peter Bendzko, Stephen Heymann, Hans Joos, Beate Kraffert, Ralf Bergmann, Matthias Leiser
  • Publication number: 20070082344
    Abstract: An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3? side of a target SNP base is A, while a base adjacent with one base spaced apart is A. According to the present invention, the 3? end base is designed to be the base corresponding to SNP; the second base from the 3? end to be C; the third base from the 3? end to be any one of A or C; and the base sequence of from the fourth from the 3? end to the 5? end base to be completely complementary to the sequence of from a base three bases away from the target SNP base on the 3? side to a desired base.
    Type: Application
    Filed: March 1, 2006
    Publication date: April 12, 2007
    Inventors: Hidenobu Yaku, Hiroaki Oka, Tetsuo Yukimasa
  • Publication number: 20070082345
    Abstract: Novel human secretory proteins or membrane proteins, and full length cDNAs encoding the proteins are provided. 173 kinds of novel proteins and polynucleotides encoding these proteins have been isolated. The proteins of the present invention are useful as candidates for medicines or as target molecules for developing medicines. The polynucleotides of the present invention are used to produce these proteins.
    Type: Application
    Filed: May 8, 2006
    Publication date: April 12, 2007
    Inventors: Toshio Ota, Takao Isogai, Tetsuo Nishikawa, Yuri Kawai, Tomoyasu Sugiyama, Koji Hayashi
  • Publication number: 20070082346
    Abstract: The invention relates to methods for the quantitative or qualitative detection of an analyte in an assay and adequate reagents therefor, particularly a homogeneous binding test. According to the invention, an analyte-specific binding partner R1 comprises more than one specific binding point for a specific binding partner X that is associated with a component of a signal-forming system while a second analyte-specific binding partner R2 comprises more than one specific binding point for a specific binding partner Y which is also associated with a component of a signal-forming system.
    Type: Application
    Filed: May 31, 2006
    Publication date: April 12, 2007
    Inventors: Carsten Schelp, Michael Trier, Hrair Kirakossian
  • Publication number: 20070082347
    Abstract: Variants in TLK1, WARS2, ARTS2, MSR, AKAP9, DNAJD1, GOLPH4, RABEP1, TAP2, NARG2, DDX58, CD39, FKBP1a, SRI, XRRA1, IRF5 and AMFR genes are disclosed which are useful as biomarkers for predicting the TLK1, WARS2, ARTS2, MSR, AKAP9, DNAJD1, GOLPH4, RABEP1, TAP2, NARG2, DDX58, CD39, FKBP1a, SRI, XRRA1, IRF5 or AMFR gene expression level and the biological functions associated thereof.
    Type: Application
    Filed: June 8, 2006
    Publication date: April 12, 2007
    Applicant: Myriad Genetics, Incorporated
    Inventors: Jerry Lanchbury, Alexander Gutin, Andrey Zharkikh, Julia Reid, Kirsten Timms, Susanne Wagner, Ann-Marie Woodland
  • Publication number: 20070082348
    Abstract: An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3? side of a target SNP base is A, while a base adjacent with one base spaced apart is C. According to the present invention, the 3? end base is designed to be the base corresponding to SNP; the second base from the 3? end to be C; the third base from the 3? end to be any one of A, T or C; and the base sequence of from the fourth from the 3? end to the 5? end base to be completely complementary to the sequence of from a base three bases away from the target SNP base on the 3? side to a desired base.
    Type: Application
    Filed: June 21, 2006
    Publication date: April 12, 2007
    Inventors: Hidenobu Yaku, Hiroaki Oak, Tetsuo Yukimasa
  • Publication number: 20070082349
    Abstract: A method of detecting a target nucleic acid is disclosed, the method comprising detecting the presence of a fluorescent covalent crosslinked product from non-fluorescent precursors. The fluorescent covalent crosslinked product comprises a novel fluorophore structure. Also described are methods of synthesizing probe molecules that can form fluorescent covalent crosslinked products with nucleic acid targets and arrays comprising such probes.
    Type: Application
    Filed: July 31, 2006
    Publication date: April 12, 2007
    Inventors: Stefan Franzen, Bohdan Skalski
  • Publication number: 20070082350
    Abstract: I Methods and kits for diagnosing Alzheimer's disease and/or incipient Alzheimer's disease are disclosed. The methods and kits of the invention utilize a set of genes and their encoded proteins that are shown to be correlated with incipient Alzheimer's disease.
    Type: Application
    Filed: August 9, 2006
    Publication date: April 12, 2007
    Inventors: Philip Landfield, Nada Porter, Kuey-Chu Chen, James Geddes, Eric Blalock
  • Publication number: 20070082351
    Abstract: Provided herein are methods, kits and compositions to classify fungi. Methods are provided for classification of fungi according to established phenotypes, for example, antimicrobial susceptibility profiles. More specifically, the invention provides methods for the use of PNA probes in diagnostic applications, which will aid in the direction of appropriate therapy against fungi.
    Type: Application
    Filed: September 20, 2006
    Publication date: April 12, 2007
    Applicant: AdvanDx, Inc.
    Inventors: Henrik Stender, Mark Fiandaca
  • Publication number: 20070082352
    Abstract: Disclosed is a tip for use in atomic force microscopy. The tip includes a substrate and a three-dimensional, double-stranded nucleic acid structure attached thereto. The nucleic acid structure may have a single-stranded nucleic acid attached thereto, such as an aptamer sequence. In use, the tip having the nucleic acid structure can be brought into contact with a surface to be imaged.
    Type: Application
    Filed: September 14, 2006
    Publication date: April 12, 2007
    Inventor: Peter Cumpson
  • Publication number: 20070082353
    Abstract: There is provided a marker selection program for selecting a marker for use in genetic diagnosis. In the program, analysis is carried out by using at least two specimen databases which respectively store data of specimens belonging different populations. By carrying out analysis without integrating all specimen data into single population, information on a minority population can be surely reflected to a gene search. Since the characteristics of each population can be reflected, high-accuracy diagnosing functions can be obtained, providing a practical diagnosing system.
    Type: Application
    Filed: September 19, 2006
    Publication date: April 12, 2007
    Inventors: Yoshiko Hiraoka, Kazunori Miyazaki, Satoshi Itoh, Michie Hashimoto, Shunji Mishiro
  • Publication number: 20070082354
    Abstract: A method for isolating RNA from RNA containing samples wherein the RNA containing sample is treated with at least one DNase and/or another enzyme like proteases or collagenases for purification of RNA in presence of a complex of ribonucleosides and the oxovanadyl ion which is capable of inhibiting RNases present in the RNA containing samples and removing the complex of ribonucleosides and the oxovanadyl ion prior to down-stream processing of the RNA of the RNA containing sample by contacting the sample of the forgoing step with a chelating agent immobilized to a support, the chelating agent having sufficient affinity to the complex of ribonucleosides and the oxovanadyl ion so that it binds to the chemical entity and the RNA containing sample is freed from the inhibitor.
    Type: Application
    Filed: September 26, 2006
    Publication date: April 12, 2007
    Applicant: NExtTec GmbH
    Inventors: Robert-Matthias Leiser, Hamlet Balayan, Nina Fritzemeier, Gottfried Brem
  • Publication number: 20070082355
    Abstract: The present invention concerns a method for a polymerase chain reaction, in which a template nucleic acid, at least one primer, deoxyribonucleoside triphosphates as well as a DNA polymerase with proofreading activity are used. In addition, according to this invention, at least one target substrate is added to the polymerase chain reaction, whereby the efficiency of the DNA polymerase with proofreading activity is significantly increased. Any molecule that reduces or, in the optimal case, blocks the 3?,5?-exonuclease activity of the DNA polymerase used is suitable as target substrate. Technical solutions for the added substrate (target substrate) are in particular single stranded, linear oligonucleotides, hairpin oligonucleotides and RNA and DNA molecules. Furthermore, a kit is disclosed which comprise the required reagents for the implementation of the method according to the invention.
    Type: Application
    Filed: September 28, 2006
    Publication date: April 12, 2007
    Applicant: QIAGEN GmbH
    Inventors: Holger Engel, Ralf Peist
  • Publication number: 20070082356
    Abstract: The invention relates to methods of evaluating transplant rejection in a host comprising determining a heightened magnitude of gene expression of genes in rejection-associated gene clusters. The disclosed gene clusters include genes that are substantially co-expressed with cytotoxic lymphocyte pro-apoptotic genes, cytoprotective genes and several other cytokine and immune cell genes.
    Type: Application
    Filed: October 2, 2006
    Publication date: April 12, 2007
    Inventors: Terry Strom, Manikkam Suthanthiran, Lauro Vasconcellos
  • Publication number: 20070082357
    Abstract: A method of estimating a risk of the expression of an adverse drug reaction caused by the administration of irinotecan; and a method of reducing the adverse drug reaction caused by the administration of irinotecan. A polymorphism on the basis of a difference in the repeating numbers of TA repetitive sequences in the promoter region of UGT1 gene and two types of polymorphisms (bases at the 211- and 686-positions) on the basis of single nucleotide polymorphisms in the exon 1 are analyzed. Based on the analytical data, the risk of the expression of an adverse drug reaction caused by the administration of irinotecan is estimated. Further, the administration doses of irinotecan is designed for individual patients depending on the risk of the expression of the adverse drug reaction, thereby reducing the adverse drug reaction cased by the administration of irinotecan.
    Type: Application
    Filed: October 5, 2006
    Publication date: April 12, 2007
    Applicant: DAIICHI PURE CHEMICALS CO., LTD
    Inventors: Yoshinori Hasegawa, Yu-uichi Ando, Kaoru Shimokata
  • Publication number: 20070082358
    Abstract: The present invention is directed to a method for de novo assembly of genomic sequence information comprising the combination optical whole genome restriction mapping and ultra high throughput pyrosequencing.
    Type: Application
    Filed: October 10, 2006
    Publication date: April 12, 2007
    Inventors: Roderic Fuerst, Guido Kopal
  • Publication number: 20070082359
    Abstract: Methods of identifying a compound that inhibit, enhance and/or misdirect assembly of a viral capsid include providing fluorescently-labeled capsid polypeptides labeled with a fluorescent dye that changes fluorescence at high concentration, wherein assembly of the capsid polypeptides into the viral capsid results in juxtaposition of at least one of the N-terminus and C-terminus of the capsid polypeptides. In vitro assembly reactions are performed utilizing the labeled capsid polypeptide in the presence of the at least one test compound, and an amount of fluorescence is detected at at least one time point following induction of assembly, wherein the induction of assembly is detected as a change in the fluorescence of the sample.
    Type: Application
    Filed: October 12, 2006
    Publication date: April 12, 2007
    Inventor: Adam Zlotnick
  • Publication number: 20070082360
    Abstract: Magnetic particles with an outer glass surface being essentially poreless or having pores of a diameter of less then 10 nm as well as ferromagnetic particles with a glass surface are preferentially useful for the isolation of biological material from samples. They provide a quick and reliable purification.
    Type: Application
    Filed: December 12, 2006
    Publication date: April 12, 2007
    Inventors: Jorg Kleiber, Thomas Walter, Herbert Harttig, Christoph Lesniak, Martin Mennig, Michael Riedling, Helmut Schmidt
  • Publication number: 20070082361
    Abstract: The DNA of the invention are characterised in that they concern the whole or part of genes, with their reading frame, to be found in Neisseria meningitidis, but not in Neisseria gonorrhoeae, or in Neisseria lactamica except the genes involved in the biosynthesis of the polysaccharide capsule, frp A, frp C, opc , por A, rotarmase the sequence IC1106, IgA protease, pilline, pilC, transferrin binding proteins and opacity proteins. The invention also concerns the polypeptides corresponding to these DNA and the antibodies directed against these polypeptides. It is applicable in the prevention and the detection of meningococcus induced infections and meningitis.
    Type: Application
    Filed: December 14, 2006
    Publication date: April 12, 2007
    Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (I.N.S.E.R.M), MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DES WISSENSCHAFTEN E.V., SMITHKLINE BEECHAM
    Inventors: Xavier Nassif, Colin Tinsley
  • Publication number: 20070082362
    Abstract: The present invention provides a soluble T cell receptor (sTCR), which comprises (i) all or part of a TCR $g(a) chain, except the transmembrane domain thereof, and (ii) all or part of a TCR $g(b) chain, except the transmembrane domain thereof. (i) and (ii) each comprise a functional variable domain and at least a part of the constant domain of the TCR chain, and are linked by a disulphide bond between constant domain residues which is not present in native TCR, characterised in that the sTCR recognises a CD1-antigen complex, a bacterial superantigen or a peptide-MHC/superantigen complex.
    Type: Application
    Filed: July 9, 2003
    Publication date: April 12, 2007
    Inventors: Bent Jakobsen, Meir Glick
  • Publication number: 20070082363
    Abstract: The invention discloses human secreted polypeptides that circulate at a decreased level in the plasma of patients with cardiovascular disorders. The invention also provides methods of using compositions including the polypeptides, polynucleotides encoding them, and antibodies specific for these polypeptides, for diagnosis, prognosis, and treatment of cardiovascular disorders.
    Type: Application
    Filed: April 23, 2004
    Publication date: April 12, 2007
    Inventors: Lydie Bougueleret, Isabelle Cusin
  • Publication number: 20070082364
    Abstract: The antibody of the present invention, which specifically reacts with a partial peptide at the N-terminal region or the C-terminal region of NPW, which enables to quantify NPW with highly sensitivity and specifically. Moreover, this antibody is useful as an agent for preventing/treating infertility, renal edema, digestive ulcer, gastric hyperacidity, etc., and a diagnostic for these diseases.
    Type: Application
    Filed: May 27, 2004
    Publication date: April 12, 2007
    Inventors: Masaaki Mori, Yukio Shimomura
  • Publication number: 20070082365
    Abstract: Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.
    Type: Application
    Filed: October 3, 2006
    Publication date: April 12, 2007
    Applicant: Adnexus Therapeutics, Inc.
    Inventors: Dasa Lipovsek, Richard Wagner, Robert Kuimelis
  • Publication number: 20070082366
    Abstract: The present invention is directed to methods of diagnosing Alzheimer's disease in a subject by detecting alterations in the ratio of specific phosphorylated MAP kinase proteins in cells after stimulation with a protein kinase C activator. The Alzheimer's disease-specific molecular biomarkers disclosed herein are useful for the diagnosis of Alzheimer's disease, monitoring the progression of Alzheimer's disease in a subject and in screening methods for the identification of compounds for treating or preventing Alzheimer's disease. The invention is also directed to kits containing reagents for the detection and diagnosis of Alzheimer's disease using the Alzheimer's disease-specific molecular biomarkers disclosed herein.
    Type: Application
    Filed: October 11, 2005
    Publication date: April 12, 2007
    Inventors: Tapan Khan, Daniel Alkon
  • Publication number: 20070082367
    Abstract: The present application provides methods of purifying A? binding proteins having a Fc region, for example, anti-A? antibodies or antibody fusions, by adsorbing the A? binding protein to a Fc binding agent, such as, for example, Protein A or Protein G, followed by a wash with a divalent cation salt buffer to remove impurities and subsequent recovery of the adsorbed A? binding protein. The present application also features methods of eluting the purified A? binding protein as well as the incorporation of the methods within a purification train. Kits comprising components for carrying out the methods and instructions for use are also provided.
    Type: Application
    Filed: June 16, 2006
    Publication date: April 12, 2007
    Inventors: Ranganathan Godavarti, Timothy Iskra
  • Publication number: 20070082368
    Abstract: Human cell clones with increased specific binding to urotensin II have been sub-cloned from SJRH30 (ATCC® Number: CRL-2061™). These cell clones have been used for functional analyses of the biological activity of an endogeneous urotensin II receptor, as well as for identifying compounds that regulate the biological activity of an Urotensin II receptor.
    Type: Application
    Filed: August 9, 2006
    Publication date: April 12, 2007
    Inventors: Lisa Minor, Jenson Qi, Yuanping Wang