Abstract: The present invention relates to Diterpenoid Compounds, compositions comprising an effective amount of a Diterpenoid Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering an effective amount of a Diterpenoid Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, or for inducing apoptosis in a cancer or neoplastic cell. The compounds, compositions, and methods of the invention are further useful for treating or preventing a fungal infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a fungus.

Abstract: The present invention provides novel heterobifunctional and monobifunctional polyethylene glycol derivatives for the pegylation of therapeutically active proteins. The heterobifunctional PEGs which bear two different functional groups as well as the monobifunctional PEGs which contain two similar functional groups, may be used for cross-linking purposes. The cross-linking may be intramolecular between two areas within the same molecule or intermolecular between two separate molecules. The pegylated protein conjugates that are produced, retain a substantial portion of their therapeutic activity and are less immunogenic than the protein from which the conjugate is derived. New syntheses for preparing such bifunctional derivatives are described.

Abstract: A guest host assembly comprising a host assembly formed of calixarene molecules and a guest component located within the host assembly. A crystallographic assembly of layers of the calixarene molecules and stacked along the crystallographic c axis of the assembly in a repeating configuration associated together predominantly by van der Waal forces. The guest component is transferable through the host assembly in a direction normal to the stacked layers. The calixarene molecules are configured in bilayers of adjacent layers along the c axis. The bilayers are shifted along the a or b axis so the assembly, relative to a corresponding assembly of the calixarene molecules without the inclusion of the guest component is shifted. The calixarene are calix(N)arenes in which N is an integer within the range of 4–8. The calixarene molecules are distally substituted with a substituent such as methyl, ethyl, propyl, butyl amyl or phenyl groups.

Abstract: The invention relates to a process for preparing optically active 2-amino-, 2-chloro-, 2-hydroxy- or 2-alkoxy-1-alcohols by catalytically hydrogenating appropriate optically active 2-amino-, 2-chloro-, 2-hydroxy- and 2-alkoxycarboxylic acids or their acid derivatives in the presence of catalysts comprising palladium and rhenium or platinum and rhenium.

Abstract: This invention comprises a process for hydrogenation of aldehydes to alcohols using novel homogeneous catalysts. The catalysts are generated in situ under hydrogen and carbon monoxide gases in a suitable solvent, by mixing a rhodium catalyst precursor, such as Rh(CO)2 acetoacetonate and a defined ligand.

Abstract: A method is described for producing n-propyl bromide of a high degree of purity, which contains isopropyl bromide in an amount lower than 0.1% w/w, and usually lower than 0.05%. The method is characterized in that n-propanol is reacted with HBr which is in gas form, preferably dry, and which is in excess over the stoichiometric amount, wherein the excess HBr is at the end of the reaction in an aqueous solution formed from the reaction water. The invention further relates to N-propyl bromide of high purity, containing typically less than 500 ppm of isopropyl bromide.

Abstract: The invention relates to a process for the production of phenylalkanes comprising an alkylation reaction of at least one aromatic compound by at least one linear olefin having from 9 to 16 carbon atoms per molecule. Said reaction is carried out in a catalytic reactor in which n reaction zones are present each containing at least one same solid acid catalyst, n being greater than or equal to 2, and at the inlet to each of which at least one fraction of the total quantity of olefins necessary for said reaction is introduced. The phenylalkanes obtained by the process according to the invention are particularly suitable for manufacturing detergents.

Abstract: Provided is a method for the synthesis of 1,4-dicyclopropyl-1,3-butadiyne from CPA. Such butadiyne is prepared by oxidative coupling of cyclopropyl acetylene (CPA) using catalytic amounts each of copper (I)chloride and tetrametylethylenediamine (TMEDA) in isopropanol under aerobic conditions. The resulting butadiyne can serve as a fuel or a fuel additive for combustion in engines propelling motor vehicles, marine vessels, aircraft, rockets and other vehicles.

Abstract: This invention relates to middle distillates having good cold flow properties, such as the Cold Filter Plugging Point (CFPP) measured in accordance with the IP method (309), and a high Cetane number, as well as to a process for production of such distillates. More particularly, this invention relates to middle distillates produced from a mainly paraffinic synthetic crude which is produced by the reaction of CO and H2, typically by the Fischer-Tropsch (FT) process. The middle distillates of the invention are predominantly isoparaffinic, the isoparaffins being methyl, ethyl and/or propyl branched. The invention also provides a diesel fuel composition including the middle distillates in accordance with the invention. A process for preparing the middle distillates is also included in the invention.

Abstract: A skin-contacting adhesive composition is described which has improved initial tack, long-term adhesion, water uptake and translucency characteristics and may be prepared by melt extrusion. Uses of these compositions are also described, for example, their use in wound dressings.

Abstract: Disclosed are a variety of methods for achieving enhanced expression from a target nucleotide sequence in a plant e.g. comprising the step of transiently introducing into a tissue of a plant (e.g. a leaf) a first nucleic acid comprising the target nucleotide sequence and a second nucleic acid encoding a Post Transcriptional Gene Silencing (PTGS) suppressor protein (preferably of viral or plant origin), wherein the first and second nucleic acids are comprised within a single binary vector construct, or the first and second nucleic acid sequences are comprised within a first binary vector and a second binary vector construct respectively. The plant tissue may then be harvested for the protein. Such methods can give much higher levels of gene expression than are obtainable using stable transgenes, or certain replicating vectors.

Abstract: The present invention relates to a gene regulating flowering time and a method for regulating flowering time in plants using the same. More particularly, the present invention relates to a COG gene having nucleotide sequence represented by SEQ ID No: 1 which is isolated from Arabidopsis thaliana, and a method for delaying flowering time of plants by overexpressing the gene, or for inducing early flowering by repressing an expression of the gene. The COG gene and the COG protein expressed therefrom according to the present invention are useful for improvement of flowering-associated character of plants, and for identification of flowering-associated genes or proteins in other plants, etc.

Abstract: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.

Abstract: A class of wheat SBEII genes, called SBEII-1, can be used to influence properties of starch produced by a plant, including the gelatinization temperature of the starch. Such a starch is useful, for example, in certain industrial applications for the preparation or processing of foodstuffs such as bakery products.

Abstract: A constitutive plant S-adenosyl-L-methionine synthetase (SAMS) promoter and subfragments thereof and their use in promoting the expression of one or more heterologous nucleic acid fragments in plants are described.

Abstract: The present invention provides recombinant promoters that drive tissue-specific expression, and transgenes comprising such recombinant promoters. Specifically, the invention provides transgenes comprising a recombinant promoter that drives tissue-specific expression of a heterologous nucleic acid molecule in a floral organ. The invention also provides methods for using such transgenes to produce a protein in a plant host cell or transgenic plant. The invention further provides methods for producing a transgenic plant that produces, for example, longer-lasting flowers, better fragrance, or better or longer-lasting color as compared to a wild type plant.

Abstract: A site-specific recombination system and methods of use thereof are disclosed for manipulating the plastid genome of higher plants.

Abstract: The invention relates to root-specific expansin gene to regulating root growth and obstacle-touching stress resistance in the plant, and more particularly to a root growth regulating gene, GmEXP1, isolated from soybean (Glycine max), an expansin polypeptide encoded by the gene and a method for enhancing root growth of plants by overexpression of the gene in the plants.

Abstract: This invention relates to an isolated nucleic acid fragment encoding a geranylgeranyl pyrophosphate synthase. The invention also relates to the construction of a chimeric gene encoding all or a portion of the geranylgeranyl pyrophosphate synthase, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the geranylgeranyl pyrophosphate synthase in a transformed host cell.

Abstract: This invention relates to an isolated nucleic acid fragment encoding a mevalonate synthesis enzyme. The invention also relates to the construction of a chimeric gene encoding all or a portion of the mevalonate synthesis enzyme, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the mevalonate synthesis enzyme in a transformed host cell.

Abstract: The present invention is directed to promoter sequences and promoter control elements, polynucleotide constructs comprising the promoters and control elements, and methods of identifying the promoters, control elements, or fragments thereof. The invention further relates to the use of the present promoters or promoter control elements to modulate transcript levels.

Abstract: The present invention provides transgenic plants transformed with an isolated DNA encoding a monomeric anthranilate synthase. The present invention also provides an isolated DNA encoding a monomeric anthranilate synthase from Agrobacterium tumefaciens. Transformation vectors and transformed plants containing the isolated DNA and seeds derived therefrom, are also provided.

Abstract: Regulation of expression of programmed cell death, including senescence, in plants is achieved by integration of a gene or gene fragment encoding senescence-induced deoxyhypusine synthase, senescence-induced eIF-5A or both into the plant genome in antisense orientation. Plant genes encoding senescence-induced deoxyhypusine synthase and senescence-induced eIF-5A are identified and the nucleotide sequences of each, alone and in combination are used to modify senescence in transgenic plants.

Abstract: The present invention provides eukaryotic translation initiation factor non-coding regulatory element polynucleotide molecules isolated from Nicotiana tabacum, Arabidopsis thaliana, and Medicago truncatula useful for modulating transgene expression in plants. The present invention also provides expression constructs containing the polynucleotide molecules useful for modulating transgene expression in plants. The present invention also provides transgenic plants and seeds containing the polynucleotide molecules useful for modulating transgene expression in plants.

Abstract: A soybean cultivar designated 5432082 is disclosed. The invention relates to the seeds of soybean cultivar 5432082, to the plants of soybean 5432082, to plant parts of soybean cultivar 5432082 and to methods for producing a soybean plant produced by crossing soybean cultivar 5432082 with itself or with another soybean variety. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. This invention also relates to soybean cultivars or breeding cultivars and plant parts derived from soybean variety 5432082, to methods for producing other soybean cultivars, lines or plant parts derived from soybean cultivar 5432082 and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants and plant parts produced by crossing the cultivar 5432082 with another soybean cultivar.

Abstract: A soybean cultivar designated 5726175 is disclosed. The invention relates to the seeds of soybean cultivar 5726175, to the plants of soybean 5726175, to plant parts of soybean cultivar 5726175 and to methods for producing a soybean plant produced by crossing soybean cultivar 5726175 with itself or with another soybean variety. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. This invention also relates to soybean cultivars or breeding cultivars and plant parts derived from soybean variety 5726175, to methods for producing other soybean cultivars, lines or plant parts derived from soybean cultivar 5726175 and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants and plant parts produced by crossing the cultivar 5726175 with another soybean cultivar.

Abstract: A soybean cultivar designated 5939002 is disclosed. The invention relates to the seeds of soybean cultivar 5939002, to the plants of soybean 5939002, to plant parts of soybean cultivar 5939002 and to methods for producing a soybean plant produced by crossing soybean cultivar 5939002 with itself or with another soybean variety. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. This invention also relates to soybean cultivars or breeding cultivars and plant parts derived from soybean variety 5939002, to methods for producing other soybean cultivars, lines or plant parts derived from soybean cultivar 5939002 and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants and plant parts produced by crossing the cultivar 5939002 with another soybean cultivar.

Abstract: According to the invention, there is provided seed and plants of the corn variety designated I216556. The invention thus relates to the plants, seeds and tissue cultures of the variety I216556, and to methods for producing a corn plant produced by crossing a corn plant of variety I216556 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety I216556 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety I216556.

Abstract: According to the invention, there is provided seed and plants of the corn variety designated I028727. The invention thus relates to the plants, seeds and tissue cultures of the variety I028727, and to methods for producing a corn plant produced by crossing a corn plant of variety I028727 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety I028727 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety I028727.

Abstract: According to the invention, there is provided seed and plants of the corn variety designated I135168. The invention thus relates to the plants, seeds and tissue cultures of the variety I135168, and to methods for producing a corn plant produced by crossing a corn plant of variety I135168 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety I135168 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety I135168.

Abstract: According to the invention, there is provided seed and plants of the hybrid corn variety designated CH916386. The invention thus relates to the plants, seeds and tissue cultures of the variety CH916386, and to methods for producing a corn plant produced by crossing a corn plant of variety CH916386 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH916386.

Abstract: The invention relates to a sunflower seed, comprising a sunflower oil having an increased stearic acid content as compared to wild type seeds, obtainable by treating parent seeds with a mutagenic agent during a period of time and in a concentration sufficient to induce one or more mutations in the genetic trait involved in stearic acid biosynthesis resulting in an increased production of stearic acid, germinating the treated seeds and culturing progeny plants therefrom, collecting and analyzing progeny seeds, selecting seeds that have acquired the desirable genetic trait and optionally repeating the cycle of germination, culturing and collection of seeds. Preferably the seeds comprise an oil having a stearic acid content of between 19.1 and 35% by weight related to the total amount of fatty acids in the oil, and are obtainable by treating the parent seeds with an alkylating agent, such as ethyl methane sulfonate in water, or with sodium azide in water.

Abstract: Novel musical instrument strings and methods for making the same. Polymer cover combined with a low temperature resin is provided to the strings. Also disclosed are novel plastic materials comprising a film of porous fluoropolymer having UV-cured resin applied to at least a portion of the porosity of the film.

Abstract: A keyboard apparatus which is capable of enhancing key touch feeling. The keyboard apparatus has a chassis (1), and key bodies (10) to be depressed are supported by the chassis. A hammer body (20) associated with each of the key bodies is driven by the key body via engagement with the same to move in a key depressing direction to thereby impart an inertial force to the key body when the key is depressed. The state of engagement between the key body and the hammer body suddenly changes as the key depressing velocity changes across a predetermined key depressing velocity, such that when the key depressing velocity is higher than the predetermined key depressing velocity, the hammer body hardly moves in the key depressing direction, whereas when the key depressing velocity is not higher than the predetermined key depressing velocity, the hammer body moves in the key depressing direction.

Abstract: A system for supporting performer interactions with a self-organizing chemical reaction based on monitoring and interpretation of a controllable self-organizing chemical reaction contained within a reaction vessel. The self-organizing chemical reaction initially includes two or more constituent chemical reactants which may be controllably replenished. Controller elements, responsive to reaction control signals, influence the reaction. Reaction control signals are generated by a processor in response to incoming performance signals. Selectable control-conversion algorithms may be used for this purpose, permitting an incoming performance signal to responsively influence the self-organizing chemical reaction. One or more electrodes or chemical sensors, a video camera, or other monitoring devices may be used to monitor the chemical reaction and produce outgoing control signals for controlling synthesizers, signal processing, lighting, or video synthesis.

Abstract: A reverberation apparatus is designed for generating a reverberation sound from an input sound with use of an impulse response based on an instruction. In the reverberation apparatus, a first storage section stores first impulse response data representative of a first impulse response. A second storage section stores second impulse response data representative of a second impulse response which is different from the first impulse response represented by the first impulse response data. A new data creating section operates based on the first impulse response data and the second impulse response data for creating new impulse response data representative of a new impulse response in accordance with the instruction.

Abstract: A method of utilizing previous event feedback information from historical derived hammer velocity data, such as associated with a MIDI record function, for providing non-real-time feedback when controlling actuators. The use of non-real-time feedback within the present invention provides a number of advantages over the use of conventional real-time feedback mechanisms. Utilization of the non-real-time (historical) key actuation information reduces the amount of circuitry necessary for correcting the operation of the actuators (i.e. solenoids) during playback on the instrument. By way of example, a programmable circuit element receives velocity information on previous key strikes for adjusting the actuator velocity output signal which will be generated for future key strikes. The accuracy of key strike normalization provided by this method approaches that which is achievable using real-time feedback, because the velocity profiles for each key remain substantially constant during playback.

Abstract: There is provided an operator member displaceable, in response to operation by a human operator, relative to at least one displacement axis (more preferably, multi-dimensionally). Operating state of the operator member is detected and model operation information, indicative of an operating state to be taken by the operator member, is generated, so that reaction information is generated in accordance with a difference between the detected actual operating state and an operating state indicated by the model operation information. Reactive force is imparted to the operator member in accordance with the generated reaction information. In this way, a model operation amount can be informed to the human operator in the form of the reactive force. Further, by imparting separate reactive forces to a multi-axially operable operator member, appropriate information can be provided to the human operator during operation of the operator member, thereby achieving sensory feedback to the human operator.

Abstract: An alloy having a large band gap range is used in a multijunction solar cell to enhance utilization of the solar energy spectrum. In one embodiment, the alloy is In1?xGaxN having an energy bandgap range of approximately 0.7 eV to 3.4 eV, providing a good match to the solar energy spectrum. Multiple junctions having different bandgaps are stacked to form a solar cell. Each junction may have different bandgaps (realized by varying the alloy composition), and therefore be responsive to different parts of the spectrum. The junctions are stacked in such a manner that some bands of light pass through upper junctions to lower junctions that are responsive to such bands.

Abstract: A solar cell involving a silicon wafer having a basic doping, a light-receiving front side and a backside, which is provided with an interdigital semiconductor pattern, which interdigital semiconductor pattern has a first pattern of at least one first diffusion zone having a first doping and a second pattern of at least one second diffusion zone, separated from the first diffusion zone(s) and having a second doping that differs from the first doping, wherein each second diffusion zone is arranged along the sides of at least one groove extending from the backside into the silicon wafer.

Abstract: An electrical wire includes at least one electrifiable conductor, and first and second return conductors which are respectively formed on opposing sides of the at least one electrifiable conductor, such that the at least one electrifiable conductor is at least substantially entrapped by said first and second return conductors.

Abstract: The covering for used with a conductor having a thermoplastic composition. The thermoplastic composition has a poly(arylene ether), a polyolefin and a polymeric compatibilizer. The thermoplastic composition may further have a flame retardant.

Abstract: An electrical wire having a conductor and a covering disposed over the conductor wherein the covering has a thermoplastic composition. The thermoplastic composition has a poly(arylene ether); a polyolefin, a block copolymer; and flame retardant.

Abstract: A power and ground shield mesh to remove both capacitive and inductive signal coupling effects of routing in integrated circuit device. An embodiment describes the routing of a shield mesh of both power and ground lines to remove noise created by capacitive and inductive coupling. Relatively long signal lines are routed in between fully connected power and ground shield mesh which may be generated by a router during the signal routing phase or during power mesh routing phase. Leaving only the odd tracks or the even tracks for signal routing, power mesh (VDD) and ground mesh (VSS) are routed and fully interconnected leaving shorter segments and thereby reducing the RC effect of the circuit device. Another embodiment presents a technique where the signals are shielded using the power and ground mesh for a gridless routing. Another embodiment presents a multi-layer grid routing technique where signals are routed on even grid and the power and ground lines are routed on odd grid.

Abstract: There is provided a electronic parts packaging structure that includes a mounted body on which an electronic parts is mounted, the electronic parts having a connection pad, which has an etching stopper film (a copper film, a gold film, a silver film, or a conductive past film) as an uppermost film, and mounted on the mounted body to direct the connection pad upward, an interlayer insulating film for covering the electronic parts, a via hole formed in the insulating film on the connection pad of the electronic parts, and a wiring pattern connected to the connection pad via the via hole.

Abstract: Two pairs of vias are arranged in a printed circuit board. A first pair of vias, which conveys a first signal pair, is arranged in a plane that is substantially equidistant from the vias in a second pair of vias, which conveys a second signal pair. Similarly, the second pair of vias is located in a plane that is substantially equidistant from each via in the first pair of vias. In some embodiments, such an arrangement reduces the crosstalk effect of the first signal pair on the second signal pair and vice versa.

Abstract: A blind hole (3) is formed on a substrate (1) from a first side of the substrate toward a second side of the substrate (1). A conductor (11) is filled in the blind hole (3). The substrate (1) is removed from the opposite side to expose the conductor (13) filled in the blind hole (3).

Abstract: A capacitive sensing apparatus for a vehicle seat includes a deflectable dielectric mat and a flexible printed circuit that wraps around the major surfaces of the dielectric mat to define upper and lower conductor strips that overlap in a direction perpendicular to the dielectric mat. Overlapping regions of the conductor strips define an array of capacitive load cells distributed over the seating surface. A connector stub depending from the flexible printed circuit couples the conductor strips to an external circuit that measures the capacitance of the various load cells to determine occupant weight and weight distribution.

Abstract: A multifunction key assembly for inputting data to an electronic device. The multifunction key assembly has two major switches operated by a single key cap and at least four minor switches. The key cap can be displaced vertically into three major active positions and horizontally into four minor active positions, giving rise to twelve distinct output data signals for inputting to the electronic device.

Abstract: A two-stage button structure includes: a silver paste PCB, a metal dome, a film, a flexible contact body, and a button body. When the button body is pressed to a first stage, the pair of conductive blocks of the flexible contact body respectively passes through the pair of through holes of the film to respectively electrically contact the first and the second conductive areas in order to generate a first stage signal. When the button body is pressed to a second stage, the metal dome is pressed via the contact pin to touch the third conductive area and the pair of conductive blocks respectively electrically contact the first and the second conductive areas at the same time so that the second and the third conductive areas electrically connect with each other to generate a second stage signal.