Abstract: Process for the preparation of 2-aminomethylpyridine derivative of general formula (I), in which: n represents 0, 1, 2 or 3; X is halogen atom; Y may be the same or different and may be a halogen atom, a halogenoalkyl, a alkoxycarbonyl or a alkylsulphonyl

Abstract: Indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating, e.g., kinases-dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

Abstract: Chromophores having two-photon or other multi-photon absorptivity. The chromophores are based on a structure of four stilbenoid groups attached to a paracyclophane core, where each stilbenoid group comprises a nitrogen-containing organic group attached by its nitrogen atom to a stilbenoid arm. In particular embodiments, at least one of the stilbenoid groups includes a sulfonium, ammonium, selenium, iodonium or phosphonium moiety. The chromophores have utility as photo-polymerization initiators and two-photon fluorophores for biological imaging.

Abstract: A sphingomyelin analog represented by the following formula wherein R1 is C1-20 alkyl group, R2 is C1-20 alkyl group, aryl group or C1-6 alkyl group substituted by aryl group, and Z is photoaffinity-labeled group, or its optically active compound.

Abstract: An improved process for the preparation of cis-1,3-diols is described where a beta hydroxy ketone is treated with a trialkylborane or dialkylalkoxyborane or a mixture of a trialkylborane and a dialkylalkoxyborane followed by recovery and reuse of the alkylborane species to convert additional beta hydroxy ketone to the cis-1,3-diol.

Abstract: The invention relates to an improved process for the synthesis of 13-(N-Boc-?-isobutylserinyl)-14-?-hydroxybaccatin III-1,14-carbonate (I), wherein carbonation of the 1,14-hydroxy groups of the baccatin skeleton is carried out with bis(trichloromethylcarbonate and the 7-hydroxy group is protected with a trichloroacetyl group.

Abstract: The present invention provides a fluorine-containing cyclic compound represented by general formula (1): wherein R1 represents a halogen atom, and R2 and R3 each represents hydrogen or a hydrocarbon group. The above-mentioned hydrocarbon group is a straight-chain, branched or cyclic hydrocarbon group having 1 to 25 carbon atoms or an aromatic hydrocarbon group, and may contain a halogen atom, an oxygen atom, a nitrogen atom or a sulfur atom. Further, a fluorine-containing polymerizable monomer derived from the above-mentioned fluorine-containing cyclic compound, a fluorine-containing polymer compound obtained by polymerization or copolymerization using the above-mentioned compound or monomer, further a resist material and a pattern forming process using the above-mentioned polymer compound are also disclosed.

Abstract: There is provided a catalyst carrier comprising a refractory inorganic material having a sodium solubilization rate no greater than 5 ppmw/5 minutes. There is further a catalyst comprising a refractory inorganic material carrier having a sodium solubilization rate no greater than 5 ppmw/5 minutes; and one or more catalytically reactive metals deposited on said carrier. There is also provided a catalyst suitable for the vapor phase production of alkylene oxide from olefins and oxygen comprising an alumina-based carrier having a sodium solubilization rate no greater than 5 ppmw/5 minutes; and catalytically reactive silver deposited on said carrier.

Abstract: Platinum compounds, pharmaceutically acceptable salts, and prodrugs thereof. Compositions that include the platinum compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier. Methods for using the platinum compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.

Abstract: In one aspect, the invention provides a process for the preparation of compounds of Formula I wherein R1 is —CN, —OP, alkyl, aryl or heteroaryl; wherein P represents any suitable protecting group; and R2 is alkyl or aryl; by reacting a compound of Formula II wherein R1 is —CN, —OP, alkyl, aryl or heteroaryl; wherein P represents any suitable protecting group; and R2 is alkyl or aryl; with a reducing agent (e.g. sodium borohydride) in the presence of a metal halid (e.g. CeCl3) or a metal alkoxid (e.g. Ti(OiPr)4).

Abstract: A method for preparing a biphenylphosphonate compound of the following formula (I): wherein n is 2 or 3; Ar is a C6–C16 aromatic group; which comprising (a) reacting an o-phenylphenol with a phosphorus trichloride in the presence of a zinc chloride catalyst to form a 6-chloro-6H-dibenz [c,e][1,2] oxaphosphorin of the following formula (II); (b) reacting a polyhydroxybenzene compound of the formula (III) (HO)n—Ar ??(III) wherein n and Ar are defined the same as the above, with the compound of formula (II) to form a compound of the following formula (IV) wherein n and Ar are defined the same as the above; and (c) oxidizing the compound of formula (IV) in the presence of water and ozone to form the compound of formula (I).

Abstract: A method for preparing an arylphosphonite antioxidant of the formula (I) below is disclosed, wherein Ar is First, the reactants 2-phenylphenol and phosphorus trichloride are heated under the existence of a zinc chloride catalyst for producing 6-chloro-6H-dibenz[c,e][1,2]oxaphosphorin (CDOP) of the formula (II) below: Next, the excess phosphorus trichloride is removed. Finally, an organic solution of a di-hydroxylphenol compound of the formula (III), Ar—(OH)2??(III) wherein Ar is defined as the above, is heated with the CDOP of formula (II) to form the product of the formula (I).

Abstract: The invention provides methods for hydroaminating N-alkenoyl carbamates with aromatic amines.

Abstract: The synthesis of 1-(acyloxy)-alkyl carbamates of GABA analogs from 1-haloalkyl carbamates of GABA analogs are described. Also described are new 1-haloalkyl carbamates of GABA analogs.

Abstract: The present invention provides processes for producing a (4E)-5-chloro-2-isopropyl-4-pentenoate and an optical isomer of the (4E)-5-chloro-2-isopropyl-4-pentenoate, namely a process for producing a (4E)-5-chloro-2-isopropyl-4-pentenoate represented by the following formula (4), which comprises reacting a compound represented by the following formula (2) in the presence of an aprotic solvent (II) with a base (II) and then with (1E)-1,3-dichloro-1-propene to give a compound represented by the following formula (3), and dealkoxycarbonylating either ester in the compound represented by the following formula (3), and a process for producing a (S)-(4E)-5-chloro-2-isopropyl-4-pentenoate represented by the following formula (5), which comprises optically resolving a (4E)-5-chloro-2-isopropyl-4-pentenoate represented by the formula (4) obtained by the above-mentioned process (wherein R is a lower alkyl group or an aralkyl group).

Abstract: The present invention relates to a process for preparing sulfamoyl halides of primary or secondary amines, comprising the following steps: i) reacting a primary or secondary amine A1 with at least equimolar amounts of SO3 or an SO3 source in the presence of at least equimolar amounts of a tertiary amine A2, based in each case on the amine A1, and ii) reacting the reaction mixture obtained in step i) with at least the amount of a phosphorus halide required by the stoichiometry; The invention further relates to a process for preparing sulfonic diamides, comprising the preparation of sulfamoyl halides by means of carrying out steps i) and ii) and subsequently reacting the sulfamoyl halide obtained with ammonia. The invention further relates to the use of this process for preparing active herbicidal ingredients having a sulfuric diamide structure. The invention further relates to novel sulfamoyl chlorides.

Abstract: The present invention relates to a process for preparing mono-N-sulphonylated diamines by reacting diamines with sulphonyl halides in the presence of water, base and organic solvents.

Abstract: Cycloalkanone oxime is stabilized by a method comprising bringing the cycloalkanone oxime into contact with at least one compound selected from the group consisting of oxoacids, oxoacid salts, oxoacid esters, oxoacid amides and oxides of boron or phosphorus. In accordance with the invention, the thermal stability of cycloalkanone oxime can be improved.

Abstract: The invention relates to new 2,2,3,3-tetramethylcyclopropane carboxamide derivative compounds, pharmaceutical compositions thereof and uses thereof for treating psychotic disorders, neurodegenerative diseases, epilepsy and pain.

Abstract: A process for preparing (S)-(?)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide hemifumarate salt, which comprises reacting N-[4-[(2S)-tetrahydro-5-hydroxy-2-furanyl]phenyl]methanesulfonamide(IIa) with fluoroamine (III) in the presence of triacetoxyborohydride and ethyl acetate to provide [4-[-4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxylphenyl]methanesulfonamide (I) and then converting I into the hemifumarate salt Ia. A process for preparing IIa is also claimed as well as intermediates IIa-IId.

Abstract: Process for preparing aldehydes and alcohols by rhodium-catalyzed hydroformylation of olefins having 6–20 carbon atoms with subsequent separation by distillation of the output from the hydroformylation reaction into the hydroformylation products and a rhodium-containing solution and recirculation of this solution to the hydroformylation reaction, wherein the rhodium concentration of the recirculated rhodium-containing solution is 20–150 ppm by mass.

Abstract: A perfluoropolyether, a composition comprising the perfluoropolyether, a process for producing the perfluoropolyether, and a process for improving the thermostability of grease or lubricant are provided. The perfluoropolyether comprises perfluoroalkyl radical end groups in which the radical has at least 3 carbon atoms per radical and is substantially free of perfluoromethyl and perfluoroethyl end groups. The process for producing the perfluoropolyether can comprise (1) contacting a perfluoro acid halide, a C2-to C4-substituted ethyl epoxide, or a C3+ fluoroketone with a metal halide to produce an alkoxide; (2) contacting the alkoxide with either hexafluoropropylene oxide or tetrafluorooxetane to produce a second acid halide; (3) esterifying the second acid halide to an ester; (4) reducing the ester to its corresponding alcohol; (5) converting the alcohol with a base to a salt form; (6) contacting the salt form with a C3 or higher olefin to produce a fluoropolyether; and (7) fluorinating the fluoropolyether.

Abstract: A process for the preparation of diols by a Lewis acid-catalysed aldehyde addition reaction on hydroxyalkynes followed by hydrogenation is described. The process provides a wide range of diols from simple, readily available starting materials. In particular the process is suitable for preparing chiral 1,4-diols suitable for the preparation of chiral phospholane ligands for use in asymmetric catalysis.

Abstract: A reduced or partially reduced nickel-molybdenum catalyst prepared by a process having the steps of 1) reacting nickel carbonate and molybdenum oxide precursors to form nickel molybdate and 2) treating the nickel molybdate under reducing conditions to form the reduced or partially reduced nickel-molybdenum catalyst. There is also a process for making the catalyst. There is also a process for using the catalyst in the hydrogenation of an oxo aldehyde, thereby forming an oxo alcohol of high selectivity. There is also a process for forming an oxo alcohol from the hydroformylation/hydrogenation of an olefinic feedstream. There is also a process for forming an oxo alcohol by contacting formates, dimers, trimers, and organic acids with hydrogen in the presence of a reduced or partially reduced nickel-molybdenum catalyst. The foregoing processes are also useful with a catalyst having the general formula YxZ wherein Y is nickel and/or cobalt and Z is molybdenum and/or tungsten; and wherein x ranges between about 0.

Abstract: The invention relates to a process for producing a hydrocarbon component of biological origin. The process comprises at least two steps, the first one of which is a HDO step and the second one is an isomerization step operated using the counter-current flow principle. A biological raw material containing fatty acids and/or fatty acid esters serves as the feed stock.

Abstract: A system and process for producing olefins from oxygenate, e.g., methanol or dimethylether, includes a fluidized bed reaction zone that provide contact between the oxygenate and a molecular sieve catalyst such as ZSM-34 or SAPO-34. Improved ethylene selectivity is realized when the oxygenate is stagewise injected into the fluidized bed at one or more locations along the axial direction of the fluidized bed reaction zone.

Abstract: Process for producing low-molecular olefins by pyrolysis of hydrocarbons comprising mixing of feedstock with steam-diluent, preheating the resulting mixture, rapid heating the said mixture up to pyrolysis temperature and maintaining this temperature inside reactor during residence time, quenching product stream and subsequent fractionation of products. The reactor has an annular work cavity where stationary blades and rotatable work blades are located. A ring vortex flow is created and maintained in the work cavity when the work blades are rotated. A heat needed for pyrolysis is generated due to hydrodynamic drag of rotated work blades. Heating the mixture up to pyrolysis temperature is performed by mixing with hot process stream recirculated in the work cavity for a negligible time in comparison with the residence time. The process enables increase of the low-molecular olefins yield.

Abstract: A method of reconstituting an animal embryo involves transferring the nucleus from a quiescent donor cell into a suitable recipient cell. The donor cell is quiescent, in that it is caused to exit from the growth and division cycle at G1 and to arrest in the G0 state. Nuclear transfer may take place by cell fusion. The reconstituted embryo may then give rise to one or more animals. The invention is useful in the production of transgenic animals as well as non-transgenics of high genetic merit.

Abstract: The present invention relates to isolated nucleic acids encoding plant cyclotides. The invention also relates to the construction of a chimeric gene encoding all or a portion of the plant cyclotides, in sense or antisense orientation, wherein expression of the chimeric gene results in the production of altered levels of plant cyclotides in a transformed host cell.

Abstract: The present invention provides polynucleotides isolated from eucaryotic organisms which are structural genes or promoters. Such isolated polynucleotides are particularly useful in the modification of gene expression in plants. This invention also relates to compositions isolated from plants and their use in the modification of gene activation and/or expression. In a specific embodiment, the subject invention provides plant polynucleotide sequences encoding promoters that are components of the cellular activation and transcription apparatus and the use of such polynucleotide sequences in the modification of expression of genes.

Abstract: This invention relates to an isolated cellulose synthase promoter, methods for genetically altering cellulose and lignin biosynthesis, and to methods for improving strength properties of juvenile wood and fiber in trees. The invention further relates to methods for identifying regulatory elements in a cellulose synthase promoter and to methods for augmenting expression of polynucleotides operably linked to a cellulose synthase promoter.

Abstract: The present invention is directed to lentil plants having increased resistance to an imidaizolinone herbicide. One such plant described herein is the RH44 lentil variety. The present invention also includes seeds produced by these lentil plants and methods of controlling weeds in the vicinity of these lentil plants.

Abstract: According to the invention, there is provided seed and plants of the corn variety designated I133314. The invention thus relates to the plants, seeds and tissue cultures of the variety I133314, and to methods for producing a corn plant produced by crossing a corn plant of variety I133314 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety I133314 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety I133314.

Abstract: According to the invention, there is provided seed and plants of the corn variety designated I119163. The invention thus relates to the plants, seeds and tissue cultures of the variety I119163, and to methods for producing a corn plant produced by crossing a corn plant of variety I119163 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety I119163 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety I119163.

Abstract: According to the invention, there is provided seed and plants of the corn variety designated I226211. The invention thus relates to the plants, seeds and tissue cultures of the variety I226211, and to methods for producing a corn plant produced by crossing a corn plant of variety I226211 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety I226211 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety I226211.

Abstract: A novel hybrid maize variety designated 33T56 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. Methods for producing a maize plant that comprises crossing hybrid maize variety 33T56 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into 33T56 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the hybrid seed 33T56, the hybrid plant produced from the seed, and variants, mutants, and trivial modifications of hybrid 33T56. This invention further relates to methods for producing maize lines derived from hybrid maize variety 33T56 and to the maize lines derived by the use of those methods.

Abstract: For use in actuating a cymbal or the like, there being an upright support stand and an upright rod associated with the stand and attached to the cymbal to move it vertically, and there being a foot activated pedal unit remote from the stand, the combination comprising a first frame associated with the stand, and a connector unit associated with the frame, said rod connected with said connector unit to be moved longitudinally upwardly and downwardly by said unit, an elongated rotary linkage extending laterally between said pedal unit and said connector unit, the connector unit configured to convert rotary motion transmitted by the linkage to longitudinal motion transferred to said rod.

Abstract: A method and system for automatic classification of music is disclosed. A music piece is received and analyzed to determine whether the received music piece includes sounds of human singing. Based on the received music piece, the music piece can be classified as singing or instrumental music. Each of the singing music pieces can be further classified as chorus or a vocal solo piece, and the vocal solo pieces can be additionally classified by gender and voice. The instrumental music pieces are analyzed to determine whether the music piece is that of a symphony or that of a solo artist or small group of artists. The classification and storage of music pieces can be user controlled.

Abstract: A system and method for creating and/or rearranging musical content on a mobile device such as a cellphone or personal digital assistant (PDA), or on a computer for subsequent download and interactive playback on a mobile device. The method includes the creation and use of a digital music file, preferably consisting of MIDI sequence data, defining a musical composition having distinct musical parts, and the creation and use of a control file used in the rearrangement of the musical parts. The control file includes a plurality of control parameters for the musical composition, including which musical parts are active for each measure of the musical compositions. A user interface is included for allowing a user to alter one or more of the control parameters.

Abstract: In an electric connection box, even if accuracy of a relative position between a first screw passage hole and a first screw hole, as well as accuracy of a relative position between a second screw passage hole and a second screw hole, is low, the relative positional relation between the first screw passage hole and the first screw hole, as well as the relative positional relation between the second screw passage hole and the second screw hole, can be adjusted because of the provision of a gap between an outer peripheral surface of a constricted engagement portion of a provisionally-placing projection and a hole-defining peripheral surface of a mounting member at the time of mounting a connection box body on the mounting member so that the passage of a first screw through the first screw passage hole and the first screw hole, as well as the passage of a second screw through the second screw passage hole and the second screw hole, can be easily carried out.

Abstract: Disclosed herein is a junction box having a housing and a plurality of straps. The housing includes a plurality of ribs with posts extending therefrom. Each one of the straps has a plurality of receiving areas defined by a contiguous radial surface, such as a countersink surface. The posts extend through the receiving areas and securingly retain the straps against the housing. In an exemplary embodiment of the present invention, the posts are substantially frustoconical prior to assembly and may be characterized as deformed frustrums after assembly.

Abstract: A backlight module and wire mount assembly used therein. The assembly includes a base and a wire mount. The base includes a surface and a protrusion formed on the surface. A through hole is formed between the protrusion and the surface. The wire mount is disposed on the surface of the base in a manner such that it passes through the through hole. The wire mount serves to fix the wire.

Abstract: An insulation cap of a wire joint of a joined electrical wire, the insulation cap including a cap main body for receiving the wire joint being formed by joining cores of a plurality of covered wires and an electro-conductive sleeve, and a flexible fastener provided on an inner wall of the cap main body for fastening the wire joint by contacting a rear end of the electro-conductive sleeve thereon. The flexible fastener is formed as an integral part of the cap main body by fastening a molding die through a hole provided at an opposite end of a joint insertion end of the cap main body. A plurality of flexible fasteners are provided axial symmetrically to extend toward a direction of inserting the wire joint from a base formed as an integral part of the inner wall of the cap main body.

Abstract: A front end of the shielding member clamped between the fastener and the minor diameter part of the connector, and the terminal hardware is connected to the front ends of the wires. After inserting the terminal hardware into the housing, by fitting the connector into the housing, the major diameter part of the connector is connected to the shield shell made of a metal and which shield shell surrounding the terminal hardware in the housing. The front ends of the wires exposed by removing the shielding member is protected in the shielded state by being held in the housing.

Abstract: A method of sealing a cable penetration includes assembling a cable seal and inserting the cable seal into a cable penetration. Assembling the cable seal includes adhering at least a portion of a heat-shrinkable tubing to at least a portion of a cable outer jacket, and positioning a secondary elastic seal over the heat-shrinkable tubing. An example of a secondary elastic seal could be O-rings. A cap or other means provides the outer sealing surface.

Abstract: The invention is a cable and a method of producing a cable. The cable can be adapted and used for the generation of audio, video, data, electrical supply and other uses and includes at least two conductor sets running along the cable, Each conductor set includes at least two conductors wound or twisted round each other with a known degree or ratio of twist. The conductor sets are spaced apart as they run along the cable. This may be achieved by an elongate member along the cable to retain the spacing of the conductor sets. If required and with reference to the spacing between sets, the degree or ratio of twist or winding of the conductors in each set can be varied between sets. The cable has significantly improved performance with respect to conventionally available cables.

Abstract: An object of the present invention is to provide a method of manufacturing a hybrid integrated circuit device, in which multiple circuit boards are manufactured from one large metal board by dicing. The hybrid integrated circuit device of the present invention includes a circuit board with a surface provided with an insulating layer, and conductive patterns provided on the insulating layer. Circuit elements are electrically connected to the conductive patterns. Further, each side surface of the circuit board includes a first inclined portion extending obliquely downward from a peripheral portion of the surface of the circuit board, and a second inclined portion extending obliquely upward from a back surface of the circuit board and formed to be larger than the first inclined portion.

Abstract: A component fixing device capable of improving vibration resistance by fixing a component onto a circuit substrate without inhibiting productivity and, of accurately inserting a lead of the component into the circuit substrate. The component fixing device is provided with a circuit substrate having a printed wiring or the like, a mounting component having a package including electronic components forming an electronic circuit together with the print wiring and an external lead for connecting the electronic components to the print wiring and the like, and a holder made from an insulating material such as a synthetic resin, the holder being fixed to the circuit substrate and holding the mounting component. The holder is provided with holding members for holding and fixing the package of the mounting component and lead holes for guiding the lead to a through hole of the circuit substrate.

Abstract: A printed circuit board and a routing scenario thereof are disclosed. The printed circuit board includes three dielectric layers, two signal layers and several differential pairs. Some differential pairs are disposed in one signal layer, while some differential pairs are interleavingly disposed in the adjacent other signal layer. The differential pairs in one signal layer carries signals that flows to one direction, while the differential pairs in the adjacent signal layer carries signals that flows to an opposite direction. Under such a routing scenario, the crosstalk between differential pairs in adjacent signal layers may be reduced.

Abstract: According to one embodiment of the invention, an electronic device comprises a main body and a protective panel. The main body features a periphery formed by a plurality of sidewalls. The protective panel is placed over a top surface of the main body and extending outwardly beyond the periphery of the main body.