Abstract: The present invention provides methods for synthesizing novel tetrahydroquinoline derivatives that are useful for cancer chemotherapy and anti-viral applications. The present invention provides compounds useful for cancer chemotherapy and methods for the preparation of these compounds. The present invention also includes cancer chemotherapy methods.

Abstract: Compounds are disclosed which are Fab I inhibitors and are useful in the treatment bacterial infections.

Abstract: This invention relates to novel 8-aza-bicyclo[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

Abstract: The present invention relates to new pharmaceutical compositions for inhalation containing one or more, preferably one, tiotropium salt combined with one or more pharmacologically acceptable acid addition salts of a compound of formula 2?, wherein the groups R1, R2, R3 and R4 may have the meanings given in the claims and in the specification, processes for preparing them and their use in the treatment of respiratory complaints.

Abstract: Aryl substituted benzimidazole and imidazo[4,5]pyridine ethers are described as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.

Abstract: Cetylpyridinium salt of diclofenac.

Abstract: This invention relates to the provision of novel aminomethyl-substituted thiazolobenzimidazole derivatives represented by the following general formula (I) or a salt thereof. The aforementioned derivative or a salt thereof has a metabotropic glutamate receptor action and excellent oral activity and is therefore useful as a medicament. (In the formula, R1: an oxygen-containing saturated hetero ring or the like, Alk1: a lower alkylene, m: 0 or 1, Alk2: a lower alkylene which may be substituted with oxo group, n: 0 or 1, X: a bond, O, S or NR5, R3: H or the like, and R2, R4, R5, R6 and R7: the same or different from one another and each represents H or the like. Provided that R3 does not represent a lower alkyl or a halogeno-lower alkyl when X is a bond and n is 1. Also, R4 represents a group other than Me when m is 1, R1 is OH or OMe and Alk1 is a C1-3 alkylene, and further 1) when X is a bond, n is 1 and R3 is H, or 2) when X is a bond, n is 0 and R3 is cyclohexane.

Abstract: The present invention provides antineoplastic compounds of the formula: and antineoplastic methods.

Abstract: Thiazole derivatives of formula I are provided as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5, a and b have the significance given in the specification. The compounds are neuropeptide Y Y5 receptor antagonists which can be used for the treatment of obesity.

Abstract: The present invention relates to a pharmaceutical composition for the prevention and the treatment of cancers containing diaryl-isoxazole derivatives as an effective ingredient. Diaryl-isoxazole derivatives of the present invention inhibit metastasis of breast cancer cell lines and angiogenesis, so that they can be produced as a metastasis inhibitor and further as a pharmaceutical composition for the prevention and the treatment of angiogenesis related diseases including cancers, rheumatoid arthritis, psoriasis, or angiogenesis diseases caused in eyeball, etc.

Abstract: This invention relates to novel tetrazole and oxadiazalone ?-amino acids derivatives of the formula wherein G is wherein R1 through R4 are defined as in the specification, pharmaceutical compositions containing them and their use for the treatment of various central nervous system and other disorders. The cyclopropyl ?-amino acids derivatives of this invention exhibit activity as alpha2delta ligands (?2? ligands). Such compounds have affinity for the ?2? subunit of a calcium channel.

Abstract: Certain imidazole compounds are CCK1 modulators useful in the treatment of CCK1 mediated diseases.

Abstract: The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

Abstract: The invention relates to compounds of the general formula wherein Ar1, Ar2, R4, R5, R6, R7, R8, W, X, a and b have the significances given in the specification, and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling parasites on warm-blooded animals.

Abstract: The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role.

Abstract: Disclosed herein are novel spiro beta-lactone/gamma lactams for use in treating bacterial infections and cancer. The compounds are characterized by a terminal electron-withdrawing group such as a nitro group. Screening data shows antimicrobial activity against various bacterial cell lines, particularly gram-positive bacteria, and anti-cancer activity.

Abstract: Compounds of formula (I): wherein: Q represents an optionally substituted 5- or 6-membered aryl or heteroaryl ring; X represents O, S, NR5 or CR6 R7; Y represents CHOH, CHSH, NOR8, CNR8 or CNOR8; Z represents a bond, CR10R11, O, S, SO, SO2, NR10, OCR10R11, CR10R11 O or Z, R4 and Q together form an optionally substituted fused tricyclic group; R1, R1?, R3 and R3? each independently represents H, C1-6 alkyl or C1-4 alkylaryl; R2 represents CO2R8, CONR5OR9 or NR5COR9; R4 represents optionally substituted 5- or 6-membered aryl or heteroaryl; R5 represents H or C1-3 alkyl; R6 and R7 each independently represents H, C1-3 alkyl or halo; R8 represents H or C1-2 alkyl; R9 represents H or C1-3 alkyl; R10 and R11 each independently represents H, C1-6 alkyl or C1-4 alkylaryl; and physiologically functional derivatives thereof, processes for their preparation, pharmaceutical formulations containing them and their use as inhibitors of matrix metalloproteinase enzymes (MMPs) are described.

Abstract: This invention provides estrogen receptor modulators of formula I, having the structure where R1, R2, R3, and R4 are as defined in the specification, or a pharmaceutically acceptable salt thereof.

Abstract: The invention is directed to a method of treating, preventing, or inhibiting a Hepatitis C viral infection in a mammal comprising contacting the mammal with an effective amount of a compound of the formula: wherein substitutions at R1-R13, m and Y are set forth in the specification.

Abstract: The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation, particularly congestive heart failure, comprising administering to a patient in need thereof an effective amount of a compound of the formula: I or a pharmaceutically acceptable salt thereof.

Abstract: New pyrrole based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.

Abstract: HMGCo-A reductase inhibitor compounds useful as hypocholesterolemic and hypolipidemic compounds are provided. Also provided are pharmaceutical compositions of the compounds. Methods of making and methods of using the compounds are also provided.

Abstract: A method for treating anorectal disorders, comprising a step of providing a suppository containing between 1000 and 500,000 IU of an antioxidant selected from the group of Vitamin A, Vitamin C, Vitamin E; and a step of placing the suppository within the rectal cavity for a period of time required for dissolution of the suppository.

Abstract: Novel mercaptophenyl naphthyl methane compounds, their pharmaceutically acceptable salts and compositions comprised thereof are useful for the prevention or treatment of various medical indications associated with estrogen dependent diseases or syndromes related to osteoporosis, bone loss, bone formation, cardiovascular disorders, neurodegenerative disorders, menopausal disorders, physiological disorders, diabetes disorders, prostatic carcinoma, cancer of breast, cancer of uterus, cancer of the cervix and cancer of the colon, threatened or habitual abortion, obesity, ovarian development or function, post-partum lactation and depression.

Abstract: Compounds having the general formula I are useful for inhibiting serine protease enzymes, such as Tissue Factor VIIa, factor Xa, thrombin and kallikrein and have improved permeability properties.

Abstract: A papermaking method and a composition which utilize, as a drainage aid, a water-soluble anionic copolymer prepared via a water-in-oil polymerization technique that, absent a cross-linking agent, is characterized by a Huggins' constant (k?) determined in 0.01M NaCl greater than 0.75 and a storage modulus (G?) for a 1.5 wt. % actives polymer solution at 4.6 Hz greater than 175 Pa.

Abstract: A process for converting natural gas to a hydrocarbon liquid wherein a stream of natural gas at a selected pressure is mixed with a hot gas stream which is at a temperature sufficient to affect a chemical reaction and form an intermediate product stream containing reactive hydrocarbons, the intermediate product stream being quenched and the quenched intermediate product stream being reacted in a catalytic liquification zone to produce a hydrocarbon liquid.

Abstract: A process for the production of hydrocarbons from gaseous hydrocarbonaceous feed involving the steps of: i) partial oxidation conversion of the gaseous hydrocarbonaceous feed and oxygen containing gas at elevated temperature and pressure into synthesis gas; ii) catalytical conversion of synthesis gas of step i) using a cobalt based Fischer-Tropsch catalyst into a hydrocarbons comprising stream; iii) separating the hydrocarbons comprising stream of step ii) into a hydrocarbons product stream and a recycle stream; and, iv) removing carbon dioxide from the recycle stream and recycle of carbon dioxide depleted recycle stream to step i).

Abstract: A process for reclaiming sulfur-cured, vulcanized rubber by combining finely ground scrap vulcanized rubber within a specialized, twin-screw extruder capable of providing strong shearing and just-on-time mixing; adding a reclaiming agent to the extruder; and masticating the rubber scrap and reclaiming agent within the extruder until the rubber scrap is devulcanized. The present invention also discloses a unique composition of reclaiming agent, which preferably includes the following compounds: accelerators TBBS, ZMBT, MBT, and TMTM; activators zinc oxide and stearic acid; and zinc salts of fatty acids and sulfur. The reclaimed rubber is suitable for use in producing high-grade, rubber products without adding a binder, or for combining with fresh rubber compounds to produce high-specification rubber products.

Abstract: Polymerizable compositions and methods are provided that include an ethylenically unsaturated compound and an arylsulfinate salt. The polymerizable compositions are useful as hardenable dental compositions.

Abstract: Anti-bacterial composite particles which comprise a polymer base material comprising a thermal melting polymer, such as a polyolefine, exhibiting good dispersibility in a basic material resin and having a lower molecular weight or a lower softening point than that of the basic material resin, and inorganic fine particles comprising a metal having anti-bacterial activity carried thereon. An antibacterial resin composition can be prepared by melting and kneading a synthetic resin composition as the basic material resin together with the anti-bacterial composite particles and forming by known molding methods such as extrusion molding and injection molding, and can be used for producing various synthetic resin moldings which have an inorganic anti-bacterial agent uniformly dispersed in a synthetic resin composition and thus exhibits good anti-bacterial effect.

Abstract: Methods for preparing low resistivity nanocomposite layers that simultaneously offer optical clarity, wear resistance and superior functional performance. Nanofillers and a substance having a polymer are mixed. Both low-loaded and highly-loaded nanocomposites are included. Nanoscale coated and un-coated fillers may be used. Nanocomposite films may be coated on substrates.

Abstract: The present invention provides compositions that are capable of being dispersed in a target medium. The compositions include characteristic use particles entrapped within a physical entrapment phase, wherein the physical entrapment phase is dispersible in the target medium. Accordingly, the compositions of the present invention physically prevent the agglomeration or self-association of the characteristic use particles. Also disclosed are processes for manufacturing compositions that are capable of being dispersed in a target medium.

Abstract: Compositions comprising a mineral oil or wax and a liquid polysiloxane substituted by functional groups, an anionic surfactant and additionally a molecular mono- or polycarboxylic acid and optionally any emulsifiable, hydrophilic or amphiphilic polymer comprising carboxyl groups are outstanding water repellents for leather, furskins, textiles and fibrous materials.

Abstract: Aromatic and aliphatic organic thiol compounds are disclosed which can be utilized to plasticize and/or stabilize halogen-containing polymer compositions, especially poly(vinyl chloride) compositions. Compounds of the present invention are utilized in polymers normally susceptible to deterioration and color change, which typically occurs during processing of the polymer or exposure to certain environments.

Abstract: The present invention relates to a stable polymer dispersion comprising A) at least one dispersed polyolefin, B) at least one dispersing component, C) at least one ester and D) at least one ether comprising (oligo)oxyalkyl groups, the weight ratio of ester C) to ether D) being in the range from 30:1 to 1:30.

Abstract: A method for the production of a water-absorbent agent comprises mixing an absorbent resin containing a carboxyl group with an additive soluble in the aqueous solution of at least one member selected from the group consisting of inorganic acids, organic acids, and polyamino acids and a cross-linking agent capable of reacting with the carboxyl group. A water-absorbent agent obtained by adding from 0.005 to 8 parts by weight of an epoxy compound to 100 parts by weight of a water-absorbent resin, exhibiting an absorption capacity without load of at least 45 (g/g), an absorption capacity under load of 20 g/cm2 of not less than 30 (ml/g) and having a residue amount of an epoxy compound of not more than 2 ppm. A water-absorbent composition comprises a polyamino acid (salt) and a water-absorbent resin containing a carboxyl group.

Abstract: A method of forming a composition comprising adding at least one first compound that is at least one of an alkali metal salt, an ammonium salt, an alkali metal hydroxide, or an ammonium hydroxide and at least one second compound that is at least one of a Group IIA salt, a Group IIIA salt, a Group IIIB salt, a copper salt, a zinc salt, a cadmium salt, a manganese salt, an iron salt, a cobalt salt, or a nickel salt to a latex. This method allows for the formation of nanoparticles in the composition.

Abstract: Organic compositions of conductive polymers are provided. The compositions have at least one polymer selected from polypyrrole, polythiophene, or combinations and at least one colloid-forming polymeric acid dispersed in a liquid medium that is at least 60% by weight at least one organic liquid. Also provided is a method of making such compositions.

Abstract: The invention relates to an amphoteric water-soluble polymer dispersion containing polymer particles with particle diameters of 100 ?m or smaller and produced by dispersion-copolymerization of a monomer mixture comprising a methacrylate monomer containing a quaternary ammonium salt group, an acrylate monomer containing a quaternary ammonium salt group, an anionic monomer, and a (meth)acrylamide in respectively ratios specified in an aqueous salt solution in the presence of a polymer dispersant soluble in the aqueous salt solution and the invention also relates to a dewatering agent for organic sludge, a pretreatment agent or yield improver for paper making raw materials, and/or a drainage properties-enhancing agent using the amphoteric water-soluble polymer.

Abstract: Diene rubber compositions are described containing a diene elastomer, a reinforcing inorganic filler, and a coupling agent wherein the inorganic filler includes a silica having the following characteristics: (a) a BET specific surface area between 45 and 400 m2/g; (b) a CTAB specific surface area between 40 and 380 m2/g; (c) an average particle size (by mass), dw, of 20 to 300 nm; and at least one of the following characteristics, preferably two and more preferably all three: (d) a particle size distribution such that dw?/CTAB)?30; (e) a porosity which meets the criterion L/FI??0.0025 CTAB+0.85; (f) an amount of silanols per unit of surface area, NSiOH/nm2; NSiOH/nm2??0.027 CTAB+10.5. These diene rubber compositions can be used for the manufacture of tires or of semi-finished products intended for tires.

Abstract: A paint manufacturing method includes receiving each of a group of fluid prepaints at different inputs of a fluid component mixing system, determining at a computer system a first fluid prepaint ratio, and mixing the fluid prepaints in accordance with the first ratio to form a base paint at an output of the mixing system. A paint manufacturing system includes a computer-controlled prepaint mixing system. The prepaint mixing system includes multiple fluid inputs providing for computer-controllable flow of prepaints into the mixing system. The computer system includes a memory storing software instructions that configured the computer system to receive user input selecting a base paint to be produced, determine a ratio of fluid prepaints needed to produce the base paint, and regulate each fluid flow control to establish, in the determined ratio, a flow of fluid prepaints entering the fluid mixing system.

Abstract: This invention relates to a rubber composition which contains a block copolymer and a tire having at least one component comprised of such rubber composition. In one aspect of the invention, such rubber composition is comprised of a combination of at least one diene-based elastomer and liquid polymer comprised of a central polyalkylene polymer block, a first terminal hydroxyl group positioned on one end of said polyalkylene polymer block comprised of at least one primary hydroxyl group and a second terminal group positioned on the opposite end of said polyalkylene polymer block comprised of an epoxidized polyisoprene block or a hydrogenated polyisoprene block. The diene-based elastomer may be, for example, cis 1,4-polyisoprene natural rubber and/or other diene-based elastomer. The rubber composition contains reinforcement as carbon black and/or silica together with a coupling agent. The invention further relates to a tire having a tread of such rubber composition.

Abstract: A curable composition having enhanced cure speed which includes a curable component, a cure system and an additive for enhancing cure speed. The additive includes an alkali metal halide salt and the reaction product of: (a) a polyfunctional isocyanate and a member selected from the group consisting of an hydroxy and an amine; or (b) a phosgene or phosgene derivative, and a compound having 3 to 7 polyethylene glycol ether units terminated at one end with an ether group and at the other end with a reactive functional group selected from the group consisting of an amine, an amide, a thiol and an alcohol; or (c) a monohydroxy compound, a diisocyanate and a polyamine. Alternatively, in place of or in combination with the cure speed enhancing additive, an aromatic substituted (meth)acryl functionalized component may be incorporated into the curable component to achieve enhanced cure speed.

Abstract: A room-temperature-curable organopolysiloxane composition comprising: (A) an organopolysiloxane having 1.5 or more end groups having at least one hydroxyl group on the average; (B) a silane or a siloxane oligomer having three or more silicon-bonded hydrolyzable groups; (D) an inorganic powder; and either (C) microparticles of thermoplastic resin containing a platinum compound having an average diameter from 0.1 to 20 ?m; or (C1) a platinum compound; and (C2) an organosiloxane oligomer which contains aryl and alkenyl groups and has 8 or less silicon atoms in each molecule and which contains in each molecule at least one divalent organosiloxane as represented by the formula: —(R2)(R3)SiO—(R2)(R3)Si—, (where R2 is an aryl group, and R3 is an alkenyl group), in a quantity of at least 2 moles of component (C2) per 1 mole platinum atoms in component (C1).

Abstract: Polyvinyl-alcohol-stabilized redispersible powders which have plasticizing properties are obtained by drying polyvinyl-alcohol-stabilized aqueous dispersions of polymers of one or more monomers from the group of vinyl esters of optionally branched C1-18 alkylcarboxylic acids, (meth)acrylic esters of optionally branched C1-15 alcohols, dienes, olefins, vinylaromatics and vinylhalides, in the presence of a copolymer formed from a) one or more monomers from the group of ethylenically unsaturated monocarboxylic acids, ethylenically unsaturated dicarboxylic acids and their anhydrides, each having 4 to 8 carbon atoms, and salts thereof, b) one or more ethylenically unsaturated compounds containing sulfonic, sulfuric, and/or phosphonic acid groups, and salts thereof, and c) one or more monomers from the group consisting of vinyl esters of optionally branched C1-18 alkylcarboxylic acids and (meth)acrylic esters of optionally branched C1-15 alcohols.

Abstract: A fuel tank produced in such a manner that an upper shell and a lower shell melt-molded as two split molded parts from a PPS resin composition are welded to each other at a welding portion. The PPS resin composition contains (a) 60% by weight to 95% by weight of a PPS resin, and (b) 5% by weight to 40% by weight of an olefin resin. The (a) PPS resin contains (a-1) a PPS resin having an MFR of 90 g/10 min to 350 g/10 min and an amount of extracts by chloroform of 2.2% by weight to 4.5% by weight. The (b) olefin resin contains (b-1) a specific olefin copolymer, and (b-2) an ethylene-?-olefin copolymer. The MFR of the PPS resin composition is 15 g/10 min to 50 g/10 min.

Abstract: A method of nucleating a propylene homo- or copolymer, the method comprising contacting the propylene polymer with a semi-crystalline branched or coupled polymeric nucleating agent under nucleation conditions. In one embodiment, the propylene homopolymer is characterized as having 13C NMR peaks corresponding to a regio-error at about 14.6 and about 15.7 ppm, the peaks of about equal intensity. In another embodiment, the copolymer is characterized as comprising at least about 60 weight percent (wt %) of units derived from propylene, and as having at least one of the following properties: (i) 13C NMR peaks corresponding to a regio-error at about 14.6 and about 15.7 ppm, the peaks of about equal intensity, (ii) a B-value greater than about 1.4 when the comonomer content, i.e., the units derived from ethylene and/or the unsaturated comonomer(s), of the copolymer is at least about 3 wt %, (iii) a skewness index, Six, greater than about ?1.

Abstract: Polymer blends that exhibit good impact resistance comprise a crystalline polypropylene matrix and a partly crystalline copolymer impact modifier with a molecular weight lower than that of the matrix polymer. The matrix polymer can comprise any crystalline propylene homo- or copolymer. The impact modifying copolymers are characterized as comprising at least about 60 weight percent (wt %) of units derived from propylene and, in certain embodiments, as having at least one, preferably two or more, of the following properties: (i) 13C NMR peaks corresponding to a regio-error at about 14.6 and about 15.7 ppm, the peaks of about equal intensity, (ii) a B-value greater than about 1.4 when the comonomer content of the copolymer is at least about 3 wt %, (iii) a skewness index, Six, greater than about ?1.

Abstract: Acrylic compositions which can be processed into thermoformable acrylic sheet material with variegated non-homogeneous granite appearance are disclosed. The acrylic compositions comprise a matrix of polymethyl methacrylate having dispersed within it particles of a thermoplastic such as polymethyl methacrylate and one or more comonomers wherein the thermoplastic is in the shape of thin wafers 0.05 to 9.53 mm thick, 0.18 to 12.8 wide and 0.18 to 7.62 mm long.