Abstract: The present invention relates to 2-aminomethylthieno[2,3-d]pyrimidines of the general formula (I) in which the radicals R1 to R6 have the meaning indicated in the text. The compounds show phosphodiesterase V inhibition and can be employed for the treatment of conditions of the cardiovascular system and for the treatment of potency disorders.

Abstract: A pharmaceutical compound comprising a compound of formula I and a pharmaceutically acceptable 2-amino-1,3-propanediol beside one or more pharmaceutically acceptable excipient(s).

Abstract: The present invention relates to novel triazolo-pyridines of the formula I wherein R1 is fluoro; s is an integer from two to three; R2 is (C3-C6)cycloalkyl optionally substituted by one or two moieties independently selected from the group consisting of halo, (C1-C4)alkyl, hydroxy, (C1-C6)alkoxy and (C1-C6)alkyl-(C?O)—O—; or R2 is (C1-C6)alkyl optionally substituted by one or two moieties independently selected from the group consisting of halo, (C1-C6)alkyl, hydroxy, (C1-C6)alkoxy and (C1-C6)alkyl-(C?O)—O—; with the proviso that said compound of formula I cannot be 6-[4-(2,4-Difluoro-phenyl)-oxazol-5-yl]-3-isopropyl-[1,2,4]triazolo[4,3-a]pyridine; or 6-[4-(3,4-Difluoro-phenyl)-oxazol-5-yl]-3-isopropyl-[1,2,4]triazolo[4,3-a]pyridine; to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the present invention are potent inhibitors of MAP kinases, preferably p38 kinase.

Abstract: The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel ?-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic ?-lactamase inhibitors presently available, and which do not require a ?-lactam pharmacophore. The invention also provides pharmaceutical compositions and methods for inhibiting bacterial growth.

Abstract: This invention relates to organic compounds of formula I, in which Ar1 is unsubstituted phenyl substituted by one or more halogen atoms; Ar2 is unsubstituted phenyl or phenyl substituted by one or more substituents selected from the group consisting of halogen, cyano and C1-C8-alkoxy; R1 is hydrogen or methyl optionally substituted by hydroxy; R10 is hydrogen or hydroxy; and pharmaceutically acceptable salts thereof. Compositions containing them, methods for their preparation and their use as pharmaceuticals are also described.

Abstract: Compounds of the following formula: in which R1, R2, A1, A2, X, Y, m, n, p, x and y are as defined herein. Also disclosed are pharmaceutical compositions each containing one or more of these compounds, and use thereof in treating enteroviral infection.

Abstract: The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts thereof, Formula I: wherein: (a) R5 is selected from the group consisting of (C1-C6) alkyl, (C1-C6) alkenyl, substituted aryl(C0-C4)alkyl, substituted aryloxy(C0-C4)alkyl, substituted arylthio(C0-C4)alkyl, unsubstituted aryl(C0-C4)alkyl, unsubstituted aryloxy(C0-C4)alkyl, and unsubstituted arylthio(C0-C4)alkyl; (b) T1 is C or N; (c) Q is selected from the group consisting of O, a single bond, O(CH2)q and C; (d) q is 1 or 2; (e) W is selected from the group consisting of O, S, (CH2)rN(R20)(CH2)k, NHSO2, C(O)N(R20)(CH2)r, (CH2)rN(R20)C(O), and SO2; (f) X is CmH2m; (g) m is 0, 1 or 2; (h) A is an functional group selected from the group consisting of carboxyl, C1-C3 alkylnitrile, carboxamide, and (CH2)n COOR19; and (i) R19 is selected from the group consisting of hydrogen, optionally substituted C1-C4alkyl and optionally substituted arylmethyl

Abstract: A novel process for the preparation of compounds of formula I and optionally converting a compound of formula I into a pharmaceutically acceptable salt is disclosed. The compounds of formula I and the corresponding salts, e.g. the sodium salts, are pharmaceutically active substances. Processes for the creation of intermediates are also disclosed.

Abstract: Provided herein are novel compounds of formula I below: in which the radicals are as defined, their physiologically acceptable salts, processes for their preparation, as well as methods of treating and/or preventing disorders of disorders of fatty acid metabolism and glucose utilization disorders, and also of disorders in which insulin resistance is involved, in a patient.

Abstract: The invention is concerned with novel hexafluoroisopropanol derivatives of formula (I) wherein R1 to R6, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to LXR alpha and LXR beta and can be used as medicaments.

Abstract: A compound of the general formula: or pharmaceutically acceptable salts, hydrates, solvates, crystal forms or diastereomers thereof is described. A method of treating protein kinase-associated disease states using the compound of formula I is also described.

Abstract: The present invention describes linking a therapeutic agent to a compound which is known to be naturally concentrated in a tissue affected by, or that is causing, a disease, to create a prodrug for treatment of the disease. Embodiments of the present invention include a new class of carotenoid-linked drugs to treat such blinding retinal disease such as age-related macular degeneration, retinoblastoma, and diabetic macular edema. For example, the present invention comprises a method for the treatment of a disorder of the eye comprising linking a therapeutic agent to a xanthophyll carotenoid to create a prodrug, and administering a therapeutically effective amount of the prodrug to an individual in need of treatment. Provided are prodrugs for treatment of retinoblastoma, cystoid macular edema (CME), exudative age-related macular degeneration (AMD), diabetic retinopathy, diabetic macular edema, or inflammatory disorders.

Abstract: A ? crystalline form of the compound of formula (I): characterized by its powder X-ray diffraction data. Medicinal products containing the same which are useful as inhibitors of angiotensin I converting enzyme.

Abstract: Compounds of formula I are provided: wherein: R1, R2, and R3, are as defined herein, as well as pharmaceutical composition and methods using the compounds as inhibitors of plasminogen activator inhibitor (PAI-1) and as therapeutic composition for treating conditions resulting from fibrinolytic disorders, such as deep vein thrombosis, coronary heart disease and pulmonary fibrosis.

Abstract: The present invention relates to compounds of formula (I): wherein —X—Y—, R1 to R11 and n are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are mediated by CETP inhibitors.

Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.

Abstract: A stable liquid composition comprising warfarin sodium, glycerin, an alcohol such as ethanol, and a pH buffer such as a phosphate buffer providing a pH above 7 is provided. The stability of the composition is characterized by the amount of warfarin sodium in the composition degraded after 1 month at room temperature, which is 5% or less. A method for preparing the composition and a method for providing an anti-coagulant therapy are also disclosed.

Abstract: In one aspect, the present invention relates to a formulation in the form of molecular dispersion comprising i) fenofibric acid, a physiologically acceptable salt or derivative thereof and optionally other active substances, ii) a binder component comprising at least one enteric binder, and optionally iii) other physiologically acceptable excipients. In a second aspect, the present invention relates to novel salts of fenofibric acid that are photostable when compared to other salts of fenofibric acid.

Abstract: Tropolone derivatives represented by the formula (I), which have retinoid actions and are useful as active ingredients of medicaments [R1 to R4 represent hydrogen atom, an alkyl group, or an alkoxyl group; the ring represented by Ar represents an aryl ring or a heteroaryl ring; X represents a single bond, —N?N—, —CON(R5)—, —(C?C)nCON(R6)—, —N(R7)CON(R8)—, —SO2N(R9)—, —N(R10)— (R5 to R9 represent hydrogen atom or an alkyl group, n represents 1 to 3, R10 represents hydrogen atom, an alkyl group, or an acyl group), an alkylene group, an aryldiyl group, or a heterocyclic diyl group; Y represents hydrogen atom, —OR11 (R11 represents hydrogen atom, an alkyl group, or an acyl group), —NHR12 (R12 represents hydrogen atom, an alkyl group, an acyl group, or amino group), or a halogen atom

Abstract: Methods and compositions for the treatment of anti-estrogen resistant breast cancer using retinoid compounds which are modulators of Retinoid X Receptors.

Abstract: A process for the production of expanded beads, including kneading a base resin containing a polypropylene resin and having a tensile modulus of at least 1,200 MPa together with a mixture of a coloring agent and a thermoplastic polymer having a tensile modulus lower than that of the base resin to form a kneaded mixture including a matrix of the base resin and a multiplicity of domains dispersed in the matrix and each containing the thermoplastic polymer and the coloring agent. The kneaded mixture is formed into resin particles, then treated with an organic peroxide to modify surfaces of the resin particles therewith. Foaming and expanding of the surface-modified resin particles gives expanded beads having an inside region surrounded by a surface region. The heat of fusion of a high temperature peak of the surface region is lower than that of the inside region.

Abstract: An adhesive composition comprising a polymeric matrix and absorbent particles wherein at least a part of the absorbent particles are microcolloid particles. The microcolloid particles are water absorbent particles preferably having a rounded or spherical shape. The addition of microcolloids to an adhesive provides an improved moisture handling properties compared to state of the art technology as well as the rheological properties of the adhesive matrix may be less affected than by addition of traditional hydrocolloids.

Abstract: A golf ball with relatively rigid inner core and soft intermediate layer is disclosed. The rigid inner core maintains the balls' high coefficient of restitution at high impact speeds, while the soft intermediate layer provides better feel for greenside play. The intermediate layer can be made from a highly neutralized polymer, which can be thermoset or thermoplastic. The highly neutralized polymer is foamed or otherwise has its specific gravity reduced. The intermediate layer can also be made from a castable reactive liquid polymer.

Abstract: A method of depolymerizing galactomannan-type polysaccharide polymers and xanthan, preferably galactomannans, to a pre-selected lower molecular weight by irradiation with high energy electron beams. The preferred galactomannans for treatment according to this method are guar gum, guar splits and hydroxypropyl guar. In a preferred embodiment the guar gum is depolymerized preferably to a molecular weight of about 150,000 Daltons to about 200,000 Daltons. The depolymerized guar has a polydispersity of less than about 3.0 and is useful in oil well fracturing to enhance oil production.

Abstract: A liquid ink composition includes a colorant, a charge control agent, an organosol, a carrier liquid, and a storage stabilizer. The storage stabilizer is a metal salt of a metal cation and an organic anion having 15 to 30 carbon atoms. The liquid ink composition is produced by a method of adding the storage stabilizer in an effective amount to improve the dispersibility and storage stability at high temperatures without deteriorating the electrical property and the optical density of the liquid ink composition. The storage stabilizer can be a metal salt of C15 to C30 alkyl carboxylate or a metal salt of a C15 to C30 alkyl sulfonate.

Abstract: A color agent for a road marking material comprising composite particles having an average particle diameter of 0.01 to 10.0 ?m, said composite particles comprising: inorganic particles; a gluing agent coating layer formed on surface of said inorganic particle; and an organic pigment coat formed onto said gluing agent coating layer in an amount of from 1 to 500 parts by weight based on 100 parts by weight of said inorganic particles. The color agent for a road marking material, contains no harmful elements and exhibits excellent tinting strength, hiding power, light resistance and heat resistance, and is suppressed in surface activity thereof. The road marking material using the color agent, shows a less change in hue with the passage of time and an excellent retroreflective property.

Abstract: A unique treatment for pigments is provided. This treatment, which uses certain organo-phosphoric acids and/or their salts, imparts improved physical and chemical qualities including lacing resistance, improved dispersion and decreased chemical reactivity when these treated pigments are incorporated into polymeric matrices.

Abstract: An object of the present invention is to provide a polyamide resin composition having high mechanical properties and high heat resistance while achieving a satisfactory balance between various physical properties. A molded product made of this polyamide resin exhibits a lower warpage and excellent surface appearance. A method for producing the polyamide, resin composition is also provided. The present invention provides a polyamide resin composition containing a polyamide resin and swelling mica treated with a polyether compound having a bisphenol structure. The present invention also provides a method for making the polyamide resin composition including melt-mixing a polyamide resin with a polyether compound.

Abstract: An ultra high-strength hydraulic cement composition contains a binder, fine aggregates, coarse aggregates, an antifoaming agent, water and a specified admixture and has a unit amount of the binder in the range of 480-1800 kg/m3. Water and the binder are contained at a ratio of 10-25% and the admixture is contained in the amount of 0.2-3.5 weight parts per 100 weight parts of the binder. The binder may be cement or a mixture of cement and a microscopic powder admixture. The admixture is one or more selected from reaction mixtures obtained by specified two processes and partially or completely neutralized substances obtained from such a reaction mixture through these two processes and also a specified third process.

Abstract: The present invention provides polyolefin compositions that are UV stable and suitable for articles that may be exposed to sunlight. The present invention provides, in one aspect, a polyolefin homopolymer or copolymer comprising, by weight of the polyolefin: (a) from 0.001 to 2 wt % hindered amine; (b) from 0.001 to 1 wt % ethoxylated amine; and (c) from 0.001 to 1 wt phenolic antioxidant; wherein the amount of phenolic antioxidant (PA), ethoxylated amine (EA) and hindered amine (HA) present in the composition is satisfied by the equation: PA + EA HA = Q wherein Q ranges from 0.15 to 250 when each component is expressed as a weight percentage. The composition is stable towards UV radiation such that it is useful for any number of articles such as automotive components and other articles that are, for example, injection molded.

Abstract: There is disclosed a pneumatic tire having a component containing a rubber composition comprising (A) a sulfur-vulcanized rubber compound; and (B) the reaction product of (1) a methylene acceptor; and (2) a combination methylene donor comprising hexamethylenetetramine and at least one N-substituted oxymethyl melamine.

Abstract: The invention relates to phosphorus-containing flame retardant agglomerates comprising a) from 99.99 to 80% by weight of aggregates and/or primary particles composed of a phosphinic salt of the formula (I) and/or composed of a diphosphinic salt of the formula (II), and/or composed of polymers of these, where R1,R2 are identical or different and are C1-C6-alkyl, linear or branched, and/or aryl; R3 is C1-C10-alkylene, linear or branched, C6-C10-arylene, -alkylarylene or -arylalkylene; M is Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Ce, Bi, Sr, Mn, Li, Na, K and/or a protonated nitrogen base; m is from 1 to 4; n is from 1 to 4; x is from 1 to 4 and b) from 0.01 to 20% by weight of auxiliaries. The invention likewise relates to a process for the production of these phosphorus-containing flame retardant agglomerates, and also to polymeric compositions and moldings which comprise these phosphorus-containing flame retardant agglomerates.

Abstract: A film can comprise greater than or equal to about 95 wt % thermoplastic resin and about 0.001 wt % to about 5.0 wt % sulfonate salt, based on a total weight of the film, and have a UL-94 rating of VTM-0, wherein the thermoplastic resin is selected from the group consisting of polyimide, polysulfone, and copolymers, reaction products, and combinations comprising at least one of the foregoing thermoplastic resins.

Abstract: A new and improved method for pre-treating stencils is herein disclosed. A release agent provides a protective barrier when applied to stencils prior to applying paint to the surface. The release agent allows the paint to removed by soaking and/or washing the pre-treated surface with warm water.

Abstract: Processes for utilizing various emulsion polymerization procedures for preparing aqueous nanocomposite dispersions are disclosed. The disclosed processes include both in-situ polymerizations in the presence of at least partially exfoliated unmodified clays as well as admixtures of polymer dispersions with at least partially exfoliated unmodified clay dispersions. The disclosed nanocomposite dispersions are useful for preparing a variety of materials, such as coatings, adhesives, caulks, sealants, plastics additives, and thermoplastic resins. Processes for preparing polymer clay nanocomposite powders and use of these powders as plastic resin and plastics additives are also disclosed.

Abstract: A tire having a tread, where the tread includes a vulcanized rubber and silica that has been surface-modified with polymer chemically attached to the silica surface.

Abstract: The invention is directed to a pneumatic tire having a tread including a vulcanizable rubber composition including, expressed as parts by weight per 100 parts by weight of elastomer (phr), (A) 60 to 95 phr of solution-polymerized styrene-butadiene rubber with a bound styrene content of from 20 to 30 percent by weight, a vinyl 1,2 content of from 50 to 70 percent by weight based on the butadiene content, and a Tg of from about ?40° C. to about ?20° C.; (B) 5 to 15 phr of cis-1,4 polybutadiene having a Tg of from ?95° C. to ?105° C.; (C) 10 to 20 phr of 3,4-polyisoprene; (D) 30 to 70 phr of processing oil; (E) 10 to 30 phr of carbon black having an Iodine absorption ranging from 192 to 212 g/kg according to ASTM D-1510 and an oil absorption ranging from 126 to 142 cc/100 g according to ASTM D-2414; (F) 90 to 110 phr of silica; (G) 0.5 to 20 phr of a sulfur containing organosilicon compound; and (H) 10 to 20 phr of resin.

Abstract: It is an object of the present invention to provide a water-borne resin composition which can form a film being excellent in flexibility and heat resistance without reducing an insulating property and can be used suitably for a cationic electrocoating composition. A water-borne resin composition, having a hydrolysable functional group and a polymerizable unsaturated carbon bond, wherein a base resin is at least one species selected from the group consisting of a polyamide-imide resin, a polyamide resin and a polyimide resin.

Abstract: A pasty single component polyurethane adhesive is provided. The NCO terminated polyurethane prepolymer is substantially linear, contains from 2.0% to 8.0% based on the weight of the prepolymer, of highly disperse silica and up to 10% by weight, based on the weight of the prepolymer, of additives. The one component adhesive has an Expressed Volume of at least 2,000 g/min measured according to DIN EN 29048 and a Creep Resistance measure according to DIN EN 27390 below 6.0 after 5 minutes.

Abstract: A method is provided for making a reinforced polymer electrolyte membrane, such as may be used in electrolytic cells such as fuel cells, by mixing a sulfonate- or sulfonyl halide-functional polymer with a bisamidine compound and subsequently trimerizing the amidine groups of the bisamidine compound to form triazine linkages. The sulfonyl halide or sulfonate groups may then be converted to sulfonic acid groups, yielding a polymer electrolyte reinforced with a polytriazine.

Abstract: A mixture of at least two thermoplastic particles having reactive grups which when melted and mixed react to form a high molecular weight polymer. The blend of particles when molten is particularly useful in forming double insulating glass or plastic panels.

Abstract: A bone cement formulation stored as a solid component pack having 0.3 to 20 solid component pack weight percent of an elastomer and a polymer bead core having a polyacrylate terminated surface. The second component pack is a liquid component pack including an acrylate monomer. An alternate solid component pack includes 3 to 25 solid component pack weight percent of a polyacrylate and a rubber toughened polymethyl methacrylate. A cement mixing and delivering system according to the present invention includes a tube having an exit nozzle and an aperture. An end plate is adapted to seal against the interior of the tube aperture and the end plate has a plurality of needles protruding therefrom into the tube. A rotatable and slidable divider is received within the tube intermediate between the end plate and the exit nozzle. The divider includes at least two plates.

Abstract: (i) A material is developed which modifies the rigidity, tensile elongation at break and impact resistance of resins such as a polypropylene resin when used as a modifier. The invention relates to an ethylene type ternary copolymer (A) comprising (i) an ethylene, propylene or 1-butene and a higher ?-olefin having 6 to 20 carbon atoms, wherein the content of ethylene is 70 to 89 mol %, the content of propylene or 1-butene is 10 to 22 mol % and the content of a higher ?-olefin having 6 to 20 carbon atoms is 1 to 11 mol % and the molar ratio of the higher-olefin having 6 to 20 carbon atoms to the structural units except for ethylene (either propylene or 1-butene and the higher ?-olefin having 6 to 20 carbon atoms) is 1/10 to 5/10 and the ethylene type ternary copolymer has a density of 0.857 to 0.885 g/cm3. The invention also relates to (ii) a propylene type resin composition comprising a propylene type polymer (B), the ethylene type ternary copolymer (A) and an inorganic filler (C).

Abstract: The present invention relates to novel (meth)acrylic esters of polyalkoxylated trimethylolpropane of the formula where EO is O—CH2-CH2- PO is independently at each instance O—CH2-CH(CH3)- or O—CH(CH3)-CH2- n1, n2 and n3 are independently 4, 5 or 6, n1+n2+n3 is 14, 15 or 16, m1, m2 and m3 are independently 1, 2 or 3, m1+m2+m3 is 4, 5 or 6, R1, R2 and R3 are independently H or CH3, a simplified process for preparing these esters and the use of reaction mixtures thus obtainable.

Abstract: This invention relates to epoxy resins containing indole as structural unit, indole resins and resin compositions containing said epoxy resins and indole resins useful for applications such as laminating, molding, casting and adhesion on account of their excellent fire retardance, adhesiveness, moisture resistance and heat resistance. The indole resins of this invention and the epoxy resins obtained therefrom are represented by the following general formulas I and II wherein R1 is H, alkyl or the like, X is a crosslinking group represented by —C(R2R3)— or C(R4R5)—Ar—C(R4R5)— (wherein R2-R5 are H, alkyl or the like and Ar is a benzene or biphenyl ring), G is glycidyl group and n is an integer of 1-20.

Abstract: A catalyst is disclosed for the polymerization and co-polymerization of olefins with functionalized monomers. The catalyst is formed from a combination of two neutral metal complexes, L(iPr2)M(CH2Ph)(PMe3)[L=N-(2,6-diisopropylphenyl)-2-(2,6-diisopropylphenylimino)propanamide] and M(COD)2(COD=cyclooctadiene). The catalyst displays a unique mode of action and performs at ambient conditions producing high molecular weight polyolefins and co-polymers with functional groups. The polymerized olefins include ethylene, ?-olefins and functionalized olefins.

Abstract: A process for producing a propylene-ethylene block copolymer in a good morphology using a catalyst system comprising a metallocene catalyst (1) preparing high crystalline polypropylene, a metallocene catalyst (2) preparing low crystalline polypropylene, a porous carrier (3), aluminoxane (4) or a compound (4) which can be reacted with the metallocene catalysts described above to form an ionic complex and, if necessary, an organic aluminum compound (5) and a propylene-ethylene block copolymer. The resultant compound has a high transparency and a low elastic modulus.

Abstract: A process for preparing highly branched ethylene polymers comprises polymerizing ethylene over a catalyst system comprising a compound of the formula Ia or Ib and an activator, where the process is carried out at from 40 to 110° C. and a pressure of from 10 to 100 bar.

Abstract: Controlled architecture polymers made preferably with acrylamide type monomers are prepared in living-type or semi-living-type free radical polymerizations, with the architecture preferably being other than linear, such as star, branched, grafted or hyper-branched. The controlled architecture polymers have high weight average molecular weights and low viscosities, which make they particularly useful in replaceable capillary electrophoresis separation media for biological molecules, such as DNA fragments.

Abstract: Processes for making temporary wet strength additives, more particularly, processes for oxidizing a homo-crosslinking monomeric unit present in a polymer comprising the homo-crosslinking monomeric unit and a cationic monomeric unit to produce a temporary wet strength additive are provided.