Abstract: A resin composition comprises 1 to 60 parts by weight of a wollastonite fiber (in which the number-average fiber length is 1 to 30 ?m, the number-average fiber diameter is 0.1 to 10 ?m, and the proportion of the number of a fiber having a fiber length of 5 to 25 ?m relative to the total number of the fiber is 20 to 75%) and 0.1 to 20 parts by weight of an acid- or epoxy-modified olefinic resin having a melting point of 100 to 170° C., relative to 100 parts by weight of a thermoplastic resin (e.g., a polycarbonate-series resin). The weight-average molecular weight of the modified olefinic resin may be about 2.5×104 to 30×104. The resin composition may comprise a flame retardant. The combination use of the wollastonite fiber and the modified olefinic resin improves heat resistance, impact resistance and weld strength, even in the case of using a wollastonite fiber having a number-average fiber diameter of about 4 to 7 ?m and an average aspect ratio of about 1.5 to 3.

Abstract: This invention provides both a pigment dispersing resin which is a copolymer of: (A) polymerizable unsaturated monomer containing at least one kind of ionic functional group selected from the group consisting of tertiary amino group, quaternary ammonium salt and sulfonic acid group; (B) nonionic polymerizable unsaturated monomer having polyoxyalkylene chain; (C) ultraviolet-absorbing polymerizable unsaturated monomer and/or an ultraviolet-stabilizing polymerizable unsaturated monomer; and (D) other ethylenically unsaturated monomer, and water-based pigment dispersion which comprises said pigment dispersing resin, pigment, aqueous medium and, as circumstances may demand, dispersing agent as well.

Abstract: The present invention relates to cement dispersant that is a copolymerization product of a first monomer (A) comprising a carboxylic acid, a second monomer (B) comprising an alkoxylated allyl alcohol sulfate, and, optionally, a third monomer (C) comprising an alkoxylated allyl alcohol. The cement dispersant according to the invention provides improved slump life properties and water reduction properties in cement admixtures.

Abstract: An addition reaction-curable liquid silicone rubber composition includes an organopolysiloxane containing at least one Si-bonded vinyl group only at each end of its backbone and having a viscosity of from 1 to 1,000 Pa·s at 25° C., an organopolysiloxane containing at least two Si-bonded vinyl groups only in side chains on its backbone and having a viscosity of from 0.1 to 100 Pa·s at 25° C., the amount of siloxane units bonded to the vinyl groups being from 2 to 20 mole % of its total siloxane units, finely divided silica having a specific surface area of at least 50 m2/g, hexamethyldisilazane, water, an organohydrogenpolysiloxane containing at least two Si-bonded hydrogen atoms per molecule, and a hydrosilation catalyst. Another addition reaction-curable liquid silicone rubber composition additionally includes a specific non-functional dimethylpolysiloxane.

Abstract: The present invention provides an isocyanate group terminated prepolymer aqueous dispersion (A) that is composed of water and an isocyanate group terminated prepolymer (a) dispersed in the water, whose content in the (A) is in a range of 60 wt % to 85 wt %, wherein the (A) optionally contains a-surfactant in a range of 0 wt % to 10 wt % based on a weight of the (a), and a solvent in a range of 0 ppm to 5,000 ppm based on the weight of the (a). The present invention also provides a polyurethane resin aqueous dispersion (B) that is composed of a polyurethane resin (b), whose content in the (B) is in a range of 20 wt % to 65 wt %, wherein the (b) is obtained by a chain extension reaction of the (A). The present invention is capable of providing a polyurethane resin aqueous dispersion having excellent storage stability.

Abstract: This invention relates to a phytoprotein synthetic fiber and the method for the manufacture thereof. This synthetic fiber is composed of phytoprotein and polyvinyl alcohol, the phytoprotein comprising A parts of the two components, where A is equal to or greater than 5 parts and less than 23 parts, and the polyvinyl alcohol comprising B parts, where B is greater than 77 parts and equal to or less than 95 parts. The methods of manufacturing the synthetic fiber comprise a semi-finished product manufacturing process and a semi-finished product acetalization and finishing process.

Abstract: This invention discloses a process for manufacturing an elastomeric article by liquid injection molding, wherein the article has improved tensile strength and improved tear strength, said process comprising the steps of: (I) heating a curable composition comprised of (1) a liquid polymer comprised of repeat units that are derived from a conjugated diolefin monomer, wherein said liquid polymer has a weight average molecular weight which is within the range of 5,000 to 100,000, and wherein the liquid polymer is functionalized with an ether moiety, (2) a carbonyl inhibited platinum catalyst, and (3) a tetrakis(dialkyl siloxy)silane crosslinking agent, to a temperature which is within the range of 30° C. to 100° C.; (II) injecting the heated curable composition into a mold at a temperature which is within the range of 100° C. to 210° C. to produce the elastomeric article; and (III) removing the elastomeric article from the mold.

Abstract: The present invention uses a curable resin which has: in the molecule thereof, at least two crosslinking functional groups of at least one kind selected from the group consisting of epoxy group, (meth)acryloyl group, alkenylamino group and alkenyloxy group; a glass transition temperature before curing of 50 to 150° C.; a weight-average molecular weight of 10,000 to 1,000,000; and a dielectric constant of not higher than 3.5 after curing. By use of the curable resin of the above constitution, the present invention can provide a curable resin that an insulator having an excellent thermal shock resistance and an excellent dielectric property is obtained.

Abstract: The present invention relates to a masterbatch composition which contains a polyolefin base resin, polymethylmethacrylate (PMMA) pearls and a further polymeric compound obtained at least from olefinic monomers, olefinic monomers containing an ester functionality and olefinic monomers containing an ether functionality, as well as to the masterbatches obtained from this composition. The present invention is further directed to monolayer as well as multilayer films which are made using the inventive masterbatches, their methods of production and the use of said films for packaging purposes.

Abstract: Olefin polymers having a melt strength of about 5cN at 190 ° C., and when made into a film have a CD shrink of at least 20%. Some of the polymers have a comb-like structure with at least 0.3 long-chain branches per 1000 carbon atoms are disclosed. Some compositions described herein include a high molecular weight fraction and a low molecular weight fraction wherein the ratio of the molecular weight of the high molecular weight fraction to the molecular weight of the low molecular weight fraction is greater than about 1.3.

Abstract: A golf ball comprising a center comprising a polybutadiene having a molecular weight of greater than 200,000 and a resilience index of at least about 40; and a cover layer comprising a polyurethane composition formed from a prepolymer having no greater than 7.5 percent by weight unreacted isocyanate groups.

Abstract: The present invention provided a norbornene compound with cross-linkable groups and their derivative polymers, wherein said cross-linkable groups were olefin or epoxy groups. Norbornene polymers with cross-linkable side chain and their block copolymers as well as modified derivatives were prepared via living ring-open metathesis polymerization method. The resulting polymers with excellent solubility and optic properties had narrow molecular weight distribution, well-controlled molecular weight, small refraction ration and high transparency. They were also suitable for preparing hybrid materials with high thermal stability and chemical resistance.

Abstract: A composition for coating having a gas barrier property comprising coating-forming components of an epoxy resin and an amine curing agent, wherein said amine curing agent is a reaction product of (A) methaxylylenediamine or paraxylylenediamineand (B) polyfunctional compound having at least one acyl group which is capable of forming amide group moiety by reaction with a polyamine to form an oligomeror or (A), (B) and (C)monocarboxylic acid having 1 to 8 carbon atoms and/or derivative thereof and a coating and a coated film a gas barrier property the same.

Abstract: A phosphorus-containing epoxy resin has a structural unit derived from a secondary phosphine derivative represented by the following formula: wherein R1 represents an alkylene group that may have a substituent, R2 represents a cycloalkylene or arylene group that may have a substituent, and X represents an oxygen or sulfur atom.

Abstract: A process for the homopolymerisation of ethylene or the copolymerisation of ethylene and (a-olefins in a polymeristation reactor, said process carried out in the presence of a catalyst system comprising (a) a polymerisation catalyst and (b) an ionic activator is characterised in that an organometallic compound of a Group IIIB metal having at least one unit of formula: Mç0çR or Mç0çM where M is the Group IIIB metal and R is a hydrocarbyl group is added to the reactor. Preferred organometallic compounds include aluminoxanes and the process results in improved poison scavenging as well as advantages in activity profiles, catalyst activity and product characteristics. The process is particularly suitable for use with supported metallocene catalyst systems in the slurry or gas phase.

Abstract: The present invention generally relates to curable compositions free of metallic catalysts. The inventive compositions are capable of curing when applied to a metal substrate. The inventive compositions provide improved thermal performance and enhanced cure strength on oily metal surfaces.

Abstract: Ionic perfluorovinyl compounds and their uses as components of ionic conductors of the polymer type, of selective membranes or of catalysts. The compounds comprise at least one perfluorovinyl group and at least one group chosen from —O or one of the groups C?N, —C(C?N)2, —NSO2R or —C[SO2R]2 or a pentacyclic group comprising at least one N, C—C?N, CR, CCOR or CSO2R group. The compounds and/or their polymers are of use in the preparation of ionically conducting materials, electrolytes and selective membranes.

Abstract: A fluorosulfonyl group-containing compound having a high polymerization reactivity, a process for its production, a sulfonyl group-containing polymerizable monomer led from the sulfonyl group-containing compound, and a polymer obtainable by polymerizing the sulfonyl group-containing polymerizable monomer

Abstract: The present invention provided a norbornene compound with cross-linkable groups and their derivative polymers, wherein said cross-linkable groups were olefin or epoxy groups. Norbornene polymers with cross-linkable side chain and their block copolymers as well as modified derivatives were prepared via living ring-open metathesis polymerization method. The resulting polymers with excellent solubility and optic properties had narrow molecular weight distribution, well-controlled molecular weight, small refraction ration and high transparency. They were also suitable for preparing hybrid materials with high thermal stability and chemical resistance.

Abstract: Disclosed herein are processes for polymerizing ethylene, acyclic olefins, and/or selected cyclic olefins, and optionally selected olefinic esters or carboxylic acids, and other monomers. The polymerizations are catalyzed by selected transition metal compounds, and sometimes other co-catalysts. Since some of the polymerizations exhibit some characteristics of living polymerizations, block copolymers can be readily made. Many of the polymers produced are often novel, particularly in regard to their microstructure, which gives some of them unusual properties. Numerous novel catalysts are disclosed, as well as some novel processes for making them. The polymers made are useful as elastomers, molding resins, in adhesives, etc.

Abstract: A curable organopolysiloxane composition capable of forming cured products of superior optical transmittance exhibiting little heat-induced yellowing over time. A semiconductor device having semiconductor elements encapsulated in a cured product of the composition. The composition includes (A) an organopolysiloxane having at least two silicon-bonded alkenyl groups per molecule and bearing silicon-bonded aryl groups, whose content relative to all silicon-bonded organic groups is not less than 40 mol %, (B) an organopolysiloxane having at least two silicon-bonded hydrogen atoms per molecule, and (C) an organosiloxane oligomer complex of platinum, where the oligomer has not more than eight silicon atoms per molecule and bears silicon-bonded alkenyl groups and silicon-bonded aryl groups.

Abstract: A room-temperature-curable silicone rubber composition comprising (A) 100 parts by weight of a polydiorganosiloxan mixture comprising: (A-1) 20 to 95 wt. % of a polydiorganosiloxane having both molecular terminals capped with dialkoxysilyl groups or trialkoxysilyl groups, (A-2) 5 to 80 wt. % of a polydiorganosiloxane having a molecular terminal capped with dialkoxysilyl group or trialkoxysilyl group and the other molecular terminal capped with monoalkoxysilyl group, hydrosilyl group, trialkylsilyl group or trialkoxyalkylsilyl group, and (A-3) 0 to 30 wt. % of a polydiorganosiloxane having both molecular terminals capped with monoalkoxysilyl group, hydlosilyl group, trialkylsilyl group or trialkoxyalkylsilyl group, (B) one or more alkoxysilanes of the formula R5bSi(OR6)4-b or partial hydrolysis and condensation products thereof, and (C) an organotitanium compound. The composition is used as a sealant.

Abstract: Biocompatible polyarylates of tyrosine-derived diphenol compounds and poly(alkylene oxide) dicarboxylic acids, articles formed therefrom and therapeutic uses are disclosed.

Abstract: It is to provide a branched aromatic polycarbonate excellent in hue and excellent in melt properties such as melt strength.

Abstract: A preparation method of a polyester resin includes: under predetermined depolymerization conditions, mixing a polyester resin, a resin dissolvent and a polycondensation catalyst to depolymerize the polyester resin and form a first reaction mixture; adding a first monomer to the first reaction mixture to form a second reaction mixture; under predetermined polymerization conditions, adding a second monomer to the second reaction mixture to polymerize the depolymerized polyester resin and form a third reaction mixture; and adding a neutralizing agent to neutralize the polymerized reaction product of the third reaction mixture.

Abstract: A method for drying a material such as a polymer hydrogel which passes through a cohesive phase as it dries is disclosed. The method comprises agitating a composition while removing liquid until the solids content of the composition reaches a level at which the composition enters a cohesive phase, halting agitation, removing liquid from the composition in the absence of agitation, and resuming agitation. Practice of the present invention can eliminate the problems associated with adhesion of a material to itself and to process equipment during the cohesive phase.

Abstract: Agonist analogues of amylin and related pharmaceutical compositions, and methods of treatment of diabetes and other insulin-requiring states, as well as methods of treatment of hypoglycemia, are provided.

Abstract: This invention provides D-isomers of MUC7-12-mer peptide of human saliva MUC7. The isomers have antimicrobial activity comparable to that of the L-isomers and are resistant to proteolysis. These peptides can be used as antifungal and antimicrobial agents.

Abstract: A novel gene (designated 125P5C8) and its encoded protein are described. While 125P5C8 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed multiple cancers including prostate, bladder, kidney and colon cancers. Consequently, 125P5C8 provides a diagnostic and/or therapeutic target for cancers, and the 125P5C8 gene or fragment thereof, or its encoded protein or a fragment thereof used to elicit an immune response.

Abstract: The current invention provides methods of improving folding of polypeptides using a poorly folding domain as a component of a fusion protein comprising the poorly folding domain and a polypeptide of interest to be improved. The invention also provides novel green fluorescent proteins (GFPs) and red fluorescent proteins that have enhanced folding properties.

Abstract: Described is a nucleic acid coding for a protein called “cyplasin” that shows a preferential toxicity to autonomously growing mammalian cells. Cell death induced by this protein differs from both apoptosis and necrosis. An intracellular cell death which occurs when recombinantly preparing cyplasin in cell cultures can be avoided by removal of the secretion signal in the cyplasin sequence. This modification makes it possible to express the cyplasin in a mammalian cell culture which is preferable with regard to the glycosylation pattern of the obtained protein. Thus, the present invention also relates to a method of recombinantly producing a protein in eukaryotic cells, preferably mammalian cells, which is cytotoxic for said cells when applied externally.

Abstract: The invention concerns GENSET polynucleotides and polypeptides. Such GENSET products may be used as reagents in forensic analyses, as chromosome markers, as tissue/cell/organelle-specific markers, in the production of expression vectors. In addition, they may be used in screening and diagnosis assays for abnormal GENSET expression and/or biological activity and for screening compounds that may be used in the treatment of GENSET-related disorders.

Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated nucleic acids encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acids as well as methods for producing and using the polypeptides.

Abstract: This invention generally relates to methods of producing an antibody phage population having affinity for a tumor cell target expressing a metastatic phenotype. The invention further relates to antibody compositions that specifically bind to a cell surface receptor on the metastatic cell.

Abstract: A mammalian cytokine-like polypeptide, called Mammalian Cytokine-like polypeptide-10, (Zcyto10), polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and anti-idiotypic antibodies which bind to the antibodies. Zcyto10 is useful for promoting the healing of wounds and for stimulating the proliferation of platelets.

Abstract: The present invention is directed to novel antibodies that bind to polypeptides encoded by nucleic acids that are differentially expressed in melanoma tumors.

Abstract: Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.

Abstract: The invention relates to biosensors, methods for obtaining them and their use fro detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or hapten, in a heterogeneous population. The biosensor includes (i) at least one fragment of a receptor which is protein in nature, capable of binding to a ligand via an active site, where at least one amino acid residues of the fragment located in the proximity of said active site is naturally present in the form of a cystein Cys residue, or is substituted with a Cys residue, and (ii) a fluorophore coupled to the Cys residue.

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Abstract: A novel Helicobacter pylori blood group antigen binding (BAB) adhesin protein was isolated and purified, whereby said protein or fractions thereof bind specifically to fucosylated blood group antigens. The protein sequence of said adhesin is disclosed in this application. Simultaneously the DNA sequences for two genes, babA and babB, producing highly similar proteins, are disclosed. Said adhesin and/or DNA is useful for diagnose and therapy and/or prophylaxis directed against H. pylori induced infections, e.g. gastritis and acid peptic disease, i.e. active vaccination. A new immunoglobulin composition, which exhibits specific activity to a Lewisb antigen binding Helicobacter pylori adhesin, or preferably, monoclonal and/or polyclonal antibodies to said adhesin offer a new and more efficient method of treatment and/or prevention of gastrointestinal diseases, caused by Helicobacter pylori or other Helicobacter species, i.e. passive vaccination.

Abstract: The invention provides derivatives of efavirenz and methods of making derivatives of efavirenz. The derivatives include immunogenic compounds for producing antibodies to efavirenz and labeled efavirenz tracers. These compounds are useful in immunoassay methods for determining efavirenz.

Abstract: A process for the preparation of Balsalazide and its pharmaceutically acceptable salts wherein the reaction comprises: a. the intermediate N-(4-aminobenzoyl)-?-alanine is converted to N-(4-ammoniumbenzoyl)-?-alanine sulfonate salt using a sulfonic acid in water, b. the N-(4-ammoniumbenzoyl)-?-alanine sulfonate salt is treated with aqueous sodium nitrite solution at low temperature to generate N-(4-diazoniumbenzoyl)-?-alanine sulfonate salt, c. the aqueous solution obtained is quenched with aqueous disodium salicylate to furnish Balsalazide disodium solution, d. the solution is acidified to allow isolation of Balsalazide, and e. optionally converting the Balsalazide to a pharmaceutically acceptable salt (such as disodium salt).

Abstract: Compositions and methods for inducing a cardiac muscle phenotype, such as rhythmic contraction and formation of myofibrils, in a cell are described. Disclosed are nucleic acids encoding myofibrillogenesis-inducing RNA (MIR) molecules, RNA molecules (MIR) and RNA-binding proteins that bind to MIR to induce myofibrillogenesis and vectors comprising these nucleic acids. Also included is a method of promoting cardiac muscle differentiation using these compositions.

Abstract: Novel Pichia methanolica secretory signal polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods of using are disclosed. Methods of producing large amounts of recombinant proteins by employing DNA constructs having a polypeptide of interest preceded by a novel Pichia methanolica secretory signal sequence.

Abstract: Methods are provided for intein mediated trans-splicing of immobilized polypeptides and for producing cyclic polypeptides in vivo or in vitro.

Abstract: An isolated DNA molecule which encodes a novel glutamate receptor and a transformed cell expressing the receptor are provided.

Abstract: The invention provides methods for synthesizing oligonucleotides using nucleoside monomers having carbonate protected hydroxyl groups that are deprotected with ?-effect nucleophiles. The ?-effect nucleophile irreversibly cleave the carbonate protecting groups while simultaneously oxidizing the internucleotide phosphite triester linkage to a phosphodiester linkage. The procedure may be carried out in aqueous solution at neutral to mildly basic pH. The method eliminates the need for separate deprotection and oxidation steps, and, since the use of acid to remove protecting groups is unnecessary, acid-induced depurination is avoided. Fluorescent or other readily detectable carbonate protecting groups can be used, enabling monitoring of individual reaction steps during oligonucleotide synthesis. The invention is particularly useful in the highly parallel, microscale synthesis of oligonucleotides.

Abstract: A new family of silicon-based polymers has been prepared in which organic host components are bound covalently. The polymer is a polysilsesquioxane matrix comprising, for example, hosts such as cyclodextrins (CD) or calixarenes (CX).

Abstract: The present invention relates to 3,4-dihydroquinazoline derivatives as T-type calcium channel blockers and a method of preparing the same. The present invention further relates to a composition comprising the same. The composition comprising the 3,4-dihydroquinazoline derivatives of the present invention can be effectively used for preventing and treating angina pectoris, high blood pressure, myocardial disease, pain and epilepsy by blocking the T-type calcium channel.

Abstract: 2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.