Patents Issued in September 18, 2007
  • Patent number: 7271262
    Abstract: The invention relates to compounds of the formula 1 or a pharmaceutically acceptable salt, prodrug or hydrates thereof, wherein Q, A, L, R1, R2 and R3 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula 1.
    Type: Grant
    Filed: December 10, 2003
    Date of Patent: September 18, 2007
    Assignee: Pfizer Inc
    Inventors: Susan D. La Greca, Joel T. Arcari, Jinshan Chen, Matthew A. Marx, Matthew D. Wessel
  • Patent number: 7271263
    Abstract: The present invention provides a process for producing a substituted aniline compound represented by the following general formula (6): (in the formula, R1, R2 and R3 are each independently an alkyl group, an alkoxy group, an alkoxyalkyl group, a haloalkyl group, a carboxyl group, an alkoxycarbonyl group, an alkyl-carboxamide group, a nitro group, an aryl group, an arylalkyl group, an aryloxy group, a halogen atom or a hydrogen atom; and X and Y are each independently a hydrogen atom, an alkyl group, an alkoxy group, an alkoxyalkyl group, a haloalkyl group, a carboxyl group, an alkoxycarbonyl group or a halogen atom), characterized by oxidizing a substituted indole compound represented by the following general formula (3): (in the formula, R1, R2, R3, X and Y have the same definitions as given above) to give rise to the ring opening of indole ring to produce an acetanilide compound represented by the following general formula (4): (in the formula, R1, R2, R3, X and Y have the same definitions as
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: September 18, 2007
    Assignee: Ihara Chemical Industry, Co., Ltd.
    Inventors: Hidetaka Hiyoshi, Mahito Ogawa
  • Patent number: 7271264
    Abstract: The present invention provides a compound of the formula (I) wherein R1 is —H, —OH, —O(C1-C4 alkyl), —OCOC6H5, —OCO(C1-C6 alkyl), or —OSO2(C2-C6 alkyl); R0, R2 and R3 are each independently —H, —OH, —O(C1-C4 alkyl), —OCOC6H5, —OCO(C1-C6 alkyl), —OSO2(C2-C6 alkyl) or halo; R4 is 1-piperidinyl, 1-pyrrolidinyl, methyl- 1-pyrrolidinyl, dimethyl-1-pyrrolidiny, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino; n is 2 or 3 X is —S— or —HC?CH—; G is —O—, —S—, —SO—, SO2, or —N(R5)—, wherein R5 is —H or C1-C4 alkyl; and Y is —O—, —S—, —NH—, —NMe—, or —CH2—; or a pharmaceutically acceptable salt thereof; pharmaceutical compositions thereof, optionally in combination with estrogen and progestin; methods of inhibiting a disease associated with estrogen deprivation; and methods for inhibiting a disease associated with an aberrant physiological response to endogenous estrogen.
    Type: Grant
    Filed: July 18, 2003
    Date of Patent: September 18, 2007
    Assignee: Eli Lilly and Company
    Inventors: Ronald Jay Hinklin, Owen Brendan Wallace
  • Patent number: 7271265
    Abstract: The present invention provides methods and non-fluorescent carbocyanine quencher compounds having the general formula: Wherein the A moiety is a substituted pyridinium, unsubstituted pyridinium, substituted quinolinium, unsubstituted quinolinium, substituted benzazolium, unsubstituted benzazolium, substituted indolinium, or unsubstituted indolinium. The invention further provides luminescent donor molecule-quencher pairs and luminescent donor molecule-quencher-luminescent acceptor molecule conjugates wherein the quencher is a cyanine compound of the present invention. The energy transfer pairs are used to detect an analyte of interest in a sample.
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: September 18, 2007
    Assignee: Invitrogen Corporation
    Inventors: Rosaria Haugland, Ching-Ying Cheung, Stephen Yue
  • Patent number: 7271266
    Abstract: Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson s disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
    Type: Grant
    Filed: March 24, 2003
    Date of Patent: September 18, 2007
    Assignee: Merck & Co., Inc.
    Inventors: Paul E. Finke, Laura C. Meurer, John S. Debenham, Richard B. Toupence, Thomas F. Walsh
  • Patent number: 7271267
    Abstract: A nitrobenzodifuroxan compound having the chemical structure of: wherein two of the R1, R2, R3 and R4 comprise oxygen or are absent, and only one of R1 or R2 is present, and only one of R3 and R4 is present, and wherein x is hydrolyzed or hydrolyzable. The salt of the hydroxynitrobenzodifuroxan of this compound is useful in explosive compositions.
    Type: Grant
    Filed: October 31, 2005
    Date of Patent: September 18, 2007
    Assignee: The United States of America as represented by Secretary of the Navy
    Inventors: John William Fronabarger, Michael E. Sitzmann
  • Patent number: 7271268
    Abstract: The present invention provides a novel process for preparing [1-(mercaptomethyl)cyclopropyl]acetic acid with high purity and related derivatives.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: September 18, 2007
    Assignee: Formosa Laboratories Inc.
    Inventors: Rung-Tian Suen, Yu-Liang Liu, Ching-Peng Wei
  • Patent number: 7271269
    Abstract: Pharmaceutically suitable crystalline and amorphous alkali and earth-alkali salts of 2-n-butyl-4-chloro-5-hidrox-ymethyl-1-[[2?-(1 H-tetrazole-5-yl)[1.1?-biphenyl]-4-yl]-1 Himidazole have been prepared and new manufacturing, purification and isolation procedure for said salts in high purity have been described. Stable pharmaceutical compositions containing new crystalline potassium salts of 2-n-butyl-5-chloro-5hidroxymethyl-1-[[2?-(1H-tetrazole-5-yl)[1.1?-biphenyl]-44-yl]-1H-imidazole have been prepared.
    Type: Grant
    Filed: January 29, 2004
    Date of Patent: September 18, 2007
    Assignee: Lek Pharmaceuticals D.D.
    Inventors: Ljubomir Antoncic, Anton Copar, Peter Svete, Breda Husu-Kovacevic, Zoran Ham, Boris Marolt
  • Patent number: 7271270
    Abstract: This invention relates to low molecular weight, non-peptidic, non-peptidomimetic, organic molecules that act as modulators of mammalian complement C5a receptors, preferably ones that act as high affinity C5a receptor ligands and also to such ligands that act as antagonists or inverse agonists of complement C5a receptors. Preferred compounds of the invention possess some or all of the following properties in that they are: 1) multi-aryl in structure, 2) heteroaryl in structure, 3) a pharmaceutically acceptable oral dose can provide a detectable in vitro effect, 4) comprise fewer than four or preferably no amide bonds, and 5) capable of inhibiting leukocyte chemotaxis at nanomolar or sub-nanomolar concentrations. This invention also relates to pharmaceutical compositions comprising such compounds and the use of such compounds in treating a variety of inflammatory and immune system disorders. Additionally, this invention relates to the use such compounds as probes for the localization of C5a receptors.
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: September 18, 2007
    Assignee: Neurogen Corporation
    Inventors: Andrew Thurkauf, Xiao-shu He, He Zhao
  • Patent number: 7271271
    Abstract: Compounds are provided having the formula: wherein variables R0, R1, R2, R3, R4, Q, L and subscript n are as described herein. The subject compounds are useful for treatment of infammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
    Type: Grant
    Filed: June 27, 2005
    Date of Patent: September 18, 2007
    Assignee: Amgen SF, LLC
    Inventors: Zice Fu, Michael G. Johnson, An-Rong Li, Andrew P. Marcus, Julio C. Medina, Philippe Bergeron, Xiaoqi Chen, Xiaohui Du, Jeffrey Deignan, Jason A. Duquette, Darin Gustin, Jeffrey T. Mihalic
  • Patent number: 7271272
    Abstract: The present invention relates to a process for the preparation of 4-aminomethyl-3-alkoxyiminopyrrolidine methane-sulfonate, a key intermediate of quinolone antibiotics. According to the process of the present invention, the total number of steps has been shortened to 2-3 steps, the solid separation is not required, and the use of costly chemicals, particularly (BOC)2O (t-butoxycarbonyl anhydride), several organic solvents and reactants, is eliminated.
    Type: Grant
    Filed: March 6, 2004
    Date of Patent: September 18, 2007
    Assignee: LG Life Sciences Ltd.
    Inventors: Gyo-Hyun Hwang, Yeong-Dae Kim, Hyun Nam, Jay-Hyok Chang, Hyun-Ik Shin, Young-Keun Kim, Kyung Hee Lee, Jae Sung Lee
  • Patent number: 7271273
    Abstract: The invention provides a new and improved method for the preparation of 5-cyano-phtalid, which is a key intermediate in the preparation of the antidepressant compound citalopram.
    Type: Grant
    Filed: November 23, 2005
    Date of Patent: September 18, 2007
    Assignee: H. Lundbeck A/S
    Inventors: Hans Petersen, Michael Harold Rock
  • Patent number: 7271274
    Abstract: The invention relates to compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds, wherein the compounds are of the following Formulas: or a pharmaceutically acceptable salt, ester or prodrug thereof, wherein the substituents are defined in the application. The invention further provides methods of treatment of inflammatory disorders by administering the compounds.
    Type: Grant
    Filed: April 20, 2005
    Date of Patent: September 18, 2007
    Assignee: AhteroGenics, Inc.
    Inventors: Charles Q. Meng, M. David Weingarten
  • Patent number: 7271275
    Abstract: The present invention relates to a process for producing a fatty acid ester by using a fatty acid and an alcohol as starting materials, including reducing the acid value of a raw material supplied to a catalyst layer to an acid value lower than the acid value of a raw material fatty acid and then esterifying the raw material in the presence of a solid catalyst.
    Type: Grant
    Filed: October 13, 2004
    Date of Patent: September 18, 2007
    Assignee: Kao Corporation
    Inventors: Takanobu Katayama, Nobuhiro Tatsumi, Osamu Tabata
  • Patent number: 7271276
    Abstract: The present invention relates to a complex comprising a novel and stable ligand and a metal center. The ligand contains a ring, particularly a phenyl group, or a hydrocarbon group which links an amino group and PR1R2, NR1R2, OR1, SR1, or AsR1R2 group such that the structure of the ligand can be stabilized.
    Type: Grant
    Filed: June 23, 2004
    Date of Patent: September 18, 2007
    Assignee: National Sun Yat-Sen University
    Inventor: Lan-Chang Liang
  • Patent number: 7271277
    Abstract: The present invention relates to a novel fulvene compound and a preparation method thereof, and more particularly to a fulvene compound having substituted groups in the 2- and 5-positions, prepared from an unsaturated ketone having a substituted group in the ?-position and a halogen atom in the ?-position, and a preparation method thereof. The present invention also relates to a metallocene catalyst having a substituted group in the ?-position carbon of the bridge of the cyclopentadienyl group only by reaction of a fulvene compound and an anion group including the cyclopentadienyl group, and a preparation method of a polyolefin copolymer using the same.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: September 18, 2007
    Assignee: LG Chem, Ltd.
    Inventors: Young-Whan Park, Si-Geun Lee, Sung-Don Hong, Kwang-Ho Song, Boong-Goon Jeong, Dae-Woo Nam, Bun-Yeol Lee, Choong-Hoon Lee, Hyo-Sun Lee
  • Patent number: 7271278
    Abstract: Compositions comprising chromium (III) 1:3 complexes comprising amino acids and methods of use thereof are provided.
    Type: Grant
    Filed: June 28, 2006
    Date of Patent: September 18, 2007
    Assignee: The University of Wyoming
    Inventors: Nair Sreejayan, Jun Ren, Xiaoping Yang
  • Patent number: 7271279
    Abstract: The invention relates to a process for preparing unsaturated nitrites from the corresponding alkanes which comprises the steps: a) feeding an alkane into a dehydrogenation zone and catalytically dehydrogenating the alkane to the corresponding alkene to obtain a product gas stream A which comprises the alkene, unconverted alkane and possibly one or more further gas components selected from the group consisting of steam, hydrogen, carbon oxides, hydrocarbons having a lower boiling point than the alkane or the alkene (low-boilers), nitrogen and noble gases, b) at least partially removing further gas components from the product gas stream A to give a feed gas stream B which comprises the alkane and the alkene, c) feeding the feed gas stream B, ammonia, an oxygen-containing gas and, if desired, steam into an oxidation zone and catalytically ammoxidizing the alkene to the corresponding unsaturated nitrile to give a product gas stream C which comprises the unsaturated nitrile, ammoxidation by-products, unconverte
    Type: Grant
    Filed: June 25, 2002
    Date of Patent: September 18, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: Frieder Borgmeier, Frank Rosowski, Goetz-Peter Schindler
  • Patent number: 7271280
    Abstract: A process for preparing an optically active biaryl compound the formula (4): which comprises reacting an aromatic sulfonic acid ester compound of the formula (1): with an organic boron compound of the formula (2): at 70° C. or below in the presence of a nickel catalyst and a base. The biaryl compounds produced using this process possess a high optical purity and are useful as intermediates for medicaments, agrochemicals, etc.
    Type: Grant
    Filed: February 10, 2004
    Date of Patent: September 18, 2007
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Hiroshi Ueda, Isao Kurimoto
  • Patent number: 7271281
    Abstract: 2,3,3?,4?-Biphenyltetracarboxylic acid tetraester is predominantly produced by a process in which a phthalic acid diester is subjected to oxidative-coupling reaction in the presence of molecular oxygen and a catalyst comprising a rhodium-containing compound.
    Type: Grant
    Filed: October 25, 2004
    Date of Patent: September 18, 2007
    Assignee: Ube Industries, Ltd.
    Inventors: Tetsuro Tsuji, Yasushi Yamamoto, Shinji Yasuda
  • Patent number: 7271282
    Abstract: A diester represented by the formula wherein A represents a cyclohexane ring, cyclohexene ring or benzene ring, X is H or methyl group, RX and RY are the same or different and each is C3-C18 branched-chain alkyl group, C1-C18 straight-chain alkyl group, C2-C18 straight-chain alkenyl or C3-C10 cycloalkyl, provided that when A is a benzene ring, RX and RY are different from each other and —COORX and —COORY are attached to two adjacent carbon atoms of the benzene ring, and having the following properties: 1) a total acid number of 0.05 mgKOH/g or less, 2) a sulfated ash content of 10 ppm or less, 3) a sulfur content of 20 ppm or less, 4) a phosphorus content of 20 ppm or less, 5) a peroxide value of 1.0 meq/kg or less, 6) a carbonyl value of 10 or less; 7) a volume resistivity of 1×1011?·cm or more, 8) a hydroxyl value of 3 mgKOH/g or less, and 9) a water content of 100 ppm or less, a process for preparing the same and a refrigerator lubricating oil comprising the diester.
    Type: Grant
    Filed: July 19, 2000
    Date of Patent: September 18, 2007
    Assignee: New Japan Chemical Co., Ltd.
    Inventors: Yasuyuki Kawahara, Kouji Takahashi, Makiko Takii
  • Patent number: 7271283
    Abstract: Disclosed herein are high refractive index monomers that are curable by ultraviolet light. These monomers may be a component of curable compositions useful in the preparation of optical articles. Also disclosed is a method of synthesizing the monomers.
    Type: Grant
    Filed: July 21, 2004
    Date of Patent: September 18, 2007
    Assignee: General Electric Company
    Inventors: Bret Ja Chisholm, Paul Michael Smigelski, Jr., James Edward Pickett
  • Patent number: 7271284
    Abstract: Disclosed is a process for preparing a compound of the formula wherein R1 is an alkyl group having at least one ethylenic unsaturation, an arylalkyl group having at least one ethylenic unsaturation, or an alkylaryl group having at least one ethylenic unsaturation, R2 and R3 each, independently of the others, are alkylene groups, arylene groups, arylalkylene groups, or alkylarylene groups, R4 and R5 each, independently of the other, is a hydrogen atom or an alkyl group, and n is an integer representing the number of repeat amide units and is at least 1, said process comprising: (a) reacting a diacid of the formula HOOC—R2—COOH with a diamine of the formula in the presence of a catalyst, a solvent, and a coupling agent to form an oligoamide intermediate; and (b) reacting the oligoamide intermediate with an alcohol of the formula R1—OH to form the product.
    Type: Grant
    Filed: November 30, 2005
    Date of Patent: September 18, 2007
    Assignee: Xerox Corporation
    Inventors: Eniko Toma, Adela Goredema, Jennifer L. Belelie, Peter G. Odell
  • Patent number: 7271285
    Abstract: An aromatic compound (C) is reacted with carbon monoxide (D) and molecular oxygen (E) in the presence of a palladium compound catalyst (A) and a catalyst (B) and thereby yields a aromatic carboxylic acid corresponding to the aromatic compound (C) except with one or more carboxyl groups bonded to its aromatic ring. The catalyst (B) contains a heteropolyacid or a salt thereof (B1) or a mixture of oxo acids and/or salts thereof (B2), and the mixture (B2) contains, as a whole, one of P and Si and at least one selected from V, Mo and W.
    Type: Grant
    Filed: February 26, 2004
    Date of Patent: September 18, 2007
    Assignee: Daicel Chemical Industries Ltd.
    Inventors: Yasutaka Ishii, Tatsuya Nakano
  • Patent number: 7271286
    Abstract: Aromatic carboxylic acids are produced by reacting a Lewis acid: CO2 complex with aromatic hydrocarbons. The complex can be created by incubating a Strong Lewis acid and CO2 and forming a composition consisting essentially of CO2, strong Lewis acid, and Lewis acid: CO2 complex. Carboxylation of aromatic hydrocarbons to produce aromatic carboxylic acids using the composition and method in accordance with this invention provides improved yields without the use of finely divided aluminum or zinc.
    Type: Grant
    Filed: January 20, 2005
    Date of Patent: September 18, 2007
    Assignee: The University of Pittsburgh - of the Commonwealth System of Higher Education
    Inventors: Eric J. Beckman, Pradip Munshi
  • Patent number: 7271287
    Abstract: There is provided a process for producing an aromatic hydroxycarboxylic acid which is capable of suppressing the formation of by-products and enhancing the selectivity of the intended product and is free from any purifying step. The process is characterized in that it is obtained by reacting an alkali metal salt of an aromatic hydroxy compound and carbon dioxide in a non-proton polar solvent in the presence of a solid basic catalyst.
    Type: Grant
    Filed: November 9, 2005
    Date of Patent: September 18, 2007
    Assignees: Chiba Institute of Technology, Nippon Oil Corporation
    Inventors: Tatsuaki Yamaguchi, Koichi Sato
  • Patent number: 7271288
    Abstract: Disclosed is an aromatic compound expressed by the general formula (I), wherein A represents of a fused aromatic hydrocarbon moiety such as triphenylene, X represents a hydrogen-bonding site such as an atomic group containing an amide linkage, Y represents a chain functional group such as an alkyl group having 3 to 18, preferably 10 to 18 carbon atoms, and n represents an integer ranging from 2 to 10. The aromatic compound forms a molecular assembly in which the aromatic rings mutually overlap and exhibits an excellent charge carrier transfer property AX—Y)n.
    Type: Grant
    Filed: December 11, 2003
    Date of Patent: September 18, 2007
    Assignee: Kyushu University, National University Corporation
    Inventors: Masayuki Takeuchi, Masato Ikeda, Seiji Shinkai
  • Patent number: 7271289
    Abstract: Compounds of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: September 18, 2007
    Assignee: SmithKline Beecham Corporation
    Inventor: Nicola Mary Aston
  • Patent number: 7271290
    Abstract: A process comprising for example reacting a substituted or unsubstituted arylamine or a mixture thereof with a Vilsmeier reagent in a solvent system comprising acetonitrile as a sole solvent or a solvent system comprising acetonitrile and one or more solvents selected from toluene, xylene, chlorobenzene, dichlorobenzene, dichloromethane, 1,2-dichloroethane, or a combination thereof.
    Type: Grant
    Filed: September 14, 2005
    Date of Patent: September 18, 2007
    Assignee: Xerox Corporation
    Inventors: Leanne Dawn Murphy, Roger Earl Gaynor
  • Patent number: 7271291
    Abstract: The invention provides 1,3,5-tris(arylamino)benzenes represented by the general formula (I) wherein A is naphthyl, anthryl or phenanthryl group, and R is hydrogen atom or diarylamino group. These 1,3,5-tris(arylamino)benzenes have oxidation potentials in the range of about 0.5-0.6V, excellent reversibility in oxidation-reduction process, high glass transition temperatures and high heat resistance, so that they can form practicable organic semiconductor film readily by a coating method or a vacuum deposition method. In addition, they are capable of forming stable and durable amorphous film useful as high performance organic semiconductors at normal temperatures or higher with no aid of binder resins, that is, by themselves.
    Type: Grant
    Filed: March 15, 2004
    Date of Patent: September 18, 2007
    Assignee: Bando Chemical Industries, Ltd.
    Inventors: Hiroshi Inada, Nobutaka Akashi, Tomoko Hayashi
  • Patent number: 7271292
    Abstract: The invention relates to a process for continuously, distillatively removing piperazine from an ethylenediamine-piperazine mixture under pressure at elevated temperature, by discharging the ethylenediamine at the top and the piperazine at the bottom of a distillation column. For the purpose of improving the quality of the piperazine, especially its color and color stability, the piperazine is subjected directly to circulation conveying it through an evaporator unit operated at a temperature of from about 160° C. to about 170° C. and returning it into the distillation column. After a residence time of from about 30 min to about 60 min in the circulation system, the piperazine is discharged in vapor form from a side draw in the lower section of the distillation column.
    Type: Grant
    Filed: July 28, 2006
    Date of Patent: September 18, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: Michael Jödecke, Ortmund Lang, Gunther van Cauwenberge, Matthias Frauenkron
  • Patent number: 7271293
    Abstract: Disclosed is a method of controlling a separation process for removing permanganate reducing compounds from a process stream in the methanol carbonylation process for making acetic acid, where the method includes the steps of measuring the density of a stream containing acetaldehyde and methyl iodide, optionally calculating the relative concentrations of acetaldehyde and methyl iodide in the stream, and adjusting distillation or extraction process parameters based on the measured density or one or more relative concentrations calculated therefrom.
    Type: Grant
    Filed: March 2, 2004
    Date of Patent: September 18, 2007
    Assignee: Celanese International Corporation
    Inventors: David A. Trueba, Shrikant Kulkarni
  • Patent number: 7271294
    Abstract: The present invention is directed to novel cyclopropanecarboxaldehyde compounds of the general formula wherein R is a straight, branched, or cyclic hydrocarbon moiety consisting of 6 to 30 carbon atoms and containing single and/or double bonds.
    Type: Grant
    Filed: June 19, 2006
    Date of Patent: September 18, 2007
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Anubhav P. S. Narula, Edward Mark Arruda, Franc T. Schiet
  • Patent number: 7271295
    Abstract: A process for the production of 4-hydroxybutyraldehyde is described. The process comprises reacting allyl alcohol with a mixture of carbon monoxide and hydrogen in the presence of a solvent and a catalyst system comprising a rhodium complex and a 2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis[bis(3,5-di-n-alkylphenyl)phosphino]butane. The process gives high yield of 4-hydroxybutyraldehyde compared to 3-hydroxy-2-methylpropionaldehyde.
    Type: Grant
    Filed: October 13, 2006
    Date of Patent: September 18, 2007
    Assignee: Lyondell Chemical Technology, L.P.
    Inventors: Daniel F. White, Walter S. Dubner
  • Patent number: 7271296
    Abstract: The invention relates to a process for preparing phytofluene of the formula I, where a) a phosphonium salt of the formula II is condensed with an aldehyde of the formula III in a Wittig reaction to give an acetal of the formula IV b) the condensation product of the formula IV is subjected to an acid-catalyzed acetal hydrolysis to give the aldehyde of the formula V c) and V is condensed in a further Wittig reaction with a phosphonium salt of the formula VI to give phytofluene where the radicals R1, R2 and R7, and X? and Y? have the meaning sated in the description.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: September 18, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: Hansgeorg Ernst, Klaus Henrich
  • Patent number: 7271297
    Abstract: A process produces vinyl ether compounds and includes allowing a vinyl ester compound represented by following Formula (1): wherein R1, R2, R3 and R4 are the same or different and are each a hydrogen atom or an organic group, to react with a hydroxy compound represented by following Formula (2): R5OH??(2) wherein R5 is an organic group, in the presence of at least one transition element compound to thereby yield a vinyl ether compound represented by following Formula (3): wherein R2, R3, R4 and R5 have the same meanings as defined above. Such transition element compounds include iridium compounds and other compounds containing Group VIII elements.
    Type: Grant
    Filed: May 22, 2006
    Date of Patent: September 18, 2007
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Yasutaka Ishii, Tatsuya Nakano, Keizo Inoue
  • Patent number: 7271298
    Abstract: A process for isolation and purification of xanthophylls crystals from plant oleoresin is disclosed. The organic solvents involved in the process is no other than food grade alcohol. The process includes saponifying the plant oleoresin containing xanthophyll diesters, neutralizing the saponified reaction mixture with an acid and washing water-soluble impurities and other fat-soluble oil with warm water and alcohol, respectively. The process can improve purity and yield of products, by which the content and the recovery of xanthophylls are as high as 90% and 80% respectively. And the process is economical and easy to perform in industrial production.
    Type: Grant
    Filed: January 23, 2006
    Date of Patent: September 18, 2007
    Assignee: Zhe Jiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
    Inventors: Xinde Xu, Bin Shao, Di Zhou, Shuangming Ye, Yanfeng Wang, Boqiu Chen
  • Patent number: 7271299
    Abstract: Optionally alkyl-substituted 1,4-butanediol is prepared from C4-dicarboxylic acids and/or of derivatives thereof by: a) a gas stream of the C4-dicarboxylic acid or the derivative thereof in a first reactor in the gas phase to obtain a product which contains mainly optionally alkyl-substituted ?-butyro-lactone; b) removing succinic anhydride from the product of step a); c) catalytically hydrogenating the product of step b) in a second reactor in the gas phase to obtain optionally alkyl-substituted 1,4-butanediol; d) removing the desired product from intermediates, by-products and any unconverted reactants; and e) optionally recycling unconverted intermediates into one or both hydrogenation stages. The catalysts employed in each of the hydrogenation stages comprise ?95% by weight of CuO, and ?5% by weight of an oxidic support, and the second reactor has a higher pressure than the first reactor.
    Type: Grant
    Filed: June 11, 2003
    Date of Patent: September 18, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: Michael Hesse, Stephan Schlitter, Holger Borchert, Markus Schubert, Markus Rösch, Nils Bottke, Rolf-Hartmuth Fischer, Alexander Weck, Gunther Windecker, Gunnar Heydrich
  • Patent number: 7271300
    Abstract: An environmentally friendly picric acid explosive comprising, providing a nitromalondialdehyde, providing a dinitroketone, reacting the nitromalondialdehydes with the dinitroketone to produce a mixture, and subjecting the mixture to a cyclodehydrative mechanism to produce environmentally friendly picric acid explosive. Embodiments of the present invention include the picric acid explosive produced by the methods of described above.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: September 18, 2007
    Assignee: United States of America as represented by the Secretary of the Navy
    Inventor: Matthew C. Davis
  • Patent number: 7271301
    Abstract: A gold-lined pyrolysis reactor is used to pyrolyze compounds to form fluoroolefins like tetrafluoroethylene and hexafluoropropylene in high yield, with minimum to no formation of perfluoroisobutylene, chlorotrifluoroethylene, coke, salts, or polymer.
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: September 18, 2007
    Assignee: E.I. du Pont de Nemours and Company
    Inventors: Peter Gideon Gelblum, Norman Herron, Charles Joseph Noelke, Velliyur Nott Mallikarjuna Rao
  • Patent number: 7271302
    Abstract: The present invention relates to processes for the bromination of organic compounds, and to bromination microreactors for carrying out these processes.
    Type: Grant
    Filed: September 19, 2000
    Date of Patent: September 18, 2007
    Assignee: Merck Patent Gesellschaft
    Inventors: Kai Fabian, Joeran Stoldt, Hanns Wurziger, Norbert Schwesinger
  • Patent number: 7271303
    Abstract: A multi-zone process for the production of low sulfur diesel and aromatic compounds wherein C9+ hydrocarbons are hydrocracked to produce low sulfur diesel and a naphtha boiling range stream which is reformed and transalkylated within reforming and transalkylation zones to produce an aromatics-rich high-octane stream containing xylene and to balance hydrogen needs.
    Type: Grant
    Filed: September 22, 2004
    Date of Patent: September 18, 2007
    Assignee: UOP LLC
    Inventors: Paul A. Sechrist, Stanley J. Frey
  • Patent number: 7271304
    Abstract: This invention provides a process for the production of diesel boiling range hydrocarbons, the process including at least the steps of obtaining an olefinic feed stream from one or more hydrocarbon producing processes wherein the olefinic feed stream contains branched short chain olefins having a chain length of from three to eight carbon atoms, and contacting the feed stream with a shape selective medium pore acid zeolite catalyst in a pressurised reactor at elevated temperature so as to convert said short chain olefins to higher hydrocarbons. The invention also provides an apparatus for carrying out the process and recovering the catalyst for reuse.
    Type: Grant
    Filed: January 6, 2003
    Date of Patent: September 18, 2007
    Assignee: Sasol Technology (Pty) Ltd.
    Inventor: Francois Benjamin Du Toit
  • Patent number: 7271305
    Abstract: Disclosed herein is an improved method for making and obtaining para-xylene from a mixture of xylene isomers, and various embodiments of the method. The method generally includes contacting a mixture comprising xylene isomers and ethylbenzene with a para-xylene selective adsorbent to obtain a para-xylene depleted raffinate, and a desorption effluent comprising a para-xylene enriched product. The method also includes isomerizing the para-xylene depleted raffinate. The contacting step is carried out in a manner such that the raffinate need not be pressurized prior to isomerization, thus advantageously obviating expensive compression steps.
    Type: Grant
    Filed: May 1, 2003
    Date of Patent: September 18, 2007
    Assignee: BP Corporation North America Inc.
    Inventors: Bryce A. Williams, Ruth Ann Doyle, Jeffrey T. Miller
  • Patent number: 7271306
    Abstract: The present invention comprises a process for cooling a reactor effluent stream from a methanol-to-olefins reactor. The process is efficient and recovers heat from the reactor effluent stream in one or more highly usable forms, preferably high pressure superheated steam.
    Type: Grant
    Filed: January 22, 2004
    Date of Patent: September 18, 2007
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Malcolm G. Pettigrew, Wadie Malaty, Ram Mohan Lai Mallik, Stephen W. McCormick
  • Patent number: 7271307
    Abstract: The present development relates to a modification of the Houdry process for the dehydrogenation of aliphatic hydrocarbons, whereby the dehydrogenation cycle is extended, or lengthened, and hydrogen gas is added into the reaction. The combination of the extended cycle with the hydrogen introduction results in a surprising stabilization of the production rate in the dehydrogenation process. The hydrogen gas may be introduced through a recycle step. The process of the present development is demonstrated for the dehydrogenation of propane to propylene.
    Type: Grant
    Filed: October 28, 2003
    Date of Patent: September 18, 2007
    Assignee: Sud-Chemie Inc.
    Inventors: Michael A. Urbancic, Michael W. Balakos, Robert J. Gartside, Robert J. Brummer
  • Patent number: 7271308
    Abstract: The present invention relates to embodiments for a process for the isomerization of at least one alpha olefin to an internal olefin via a multi-step process resulting in a mixture comprising alkene isomers and a low level of oligomers. According to the present invention an alkylaluminum compound is used in combination with the Group VIII transition metal salt for interaction with the latter, and thereby generating catalytically active species for the isomerization of 1-alkenes to internal alkenes, wherein this mixture is subsequently combined with an acid washed clay.
    Type: Grant
    Filed: October 19, 2004
    Date of Patent: September 18, 2007
    Assignee: Hercules Incorporated
    Inventor: Jian Jian Zhang
  • Patent number: 7271309
    Abstract: In the presence of a catalyst, at least one isoparaffin having 4 to 6 C atoms per molecule is reacted with at least one olefin having 2 to 6 C atoms per molecule in a liquid phase to obtain a product containing alkylate, a suspension containing isoparaffin and a granular zeolite catalyst being supplied to the upper region of a reaction column. Below the point where the catalyst-containing suspension is supplied, an isoparaffin-olefin mixture is introduced into the reaction column, the temperatures in the reaction column being maintained in the range from 50 to 120° C. From the bottom region of the reaction column a product mixture containing alkylate is withdrawn, and in a separation by distillation alkylate product is recovered therefrom. Preferably, isoparaffin and catalyst are recovered from the separation by distillation and at least partly recirculated to the upper region of the reaction column.
    Type: Grant
    Filed: March 26, 2002
    Date of Patent: September 18, 2007
    Assignee: MG Technologies AG
    Inventors: Jürgen Eberhardt, Walter Boll, Henning Buchold, Holger Dropsch
  • Patent number: 7271310
    Abstract: A method (and concomitant kit) for treating a surface to reduce subsequent 137Cs nuclide desorption comprising contacting the surface with a first cation-containing solution, the cation being one or more of Cs+, Rb+, Ag+, Tl+, K+, and NH4+, and contacting the surface with a second cation-containing solution, the cation being one or more of Cs+, Rb+, Ag+, Tl+, K+, and NH4+, thereby reducing amounts of radioactive cesium embedded in clays found on the surface.
    Type: Grant
    Filed: February 12, 2003
    Date of Patent: September 18, 2007
    Assignee: Sandia Corporation
    Inventors: James L. Krumhansl, Patrick V. Brady, David M. Teter, Paul McConnell
  • Patent number: 7271311
    Abstract: An object of the present invention is to provide a model mammal for diabetes onset, being useful for elucidating the onset mechanism of diabetes caused by a blockage of signal transduction from insulin, and for the development of a remedy for said diabetes, and to provide a screening method of a remedy for said diabetes. A diabetic-prone transgenic mouse is prepared in a process comprising the steps of: a transgene that contains a Meg1/Grb10 gene, an imprinted gene exhibiting maternal expression, or a human GRB10 gene in the downstream of a chicken ?-actin promoter and in the upstream of a rabbit ?-globin poly A is constructed, and subsequently the transgene is microinjected into a male proneucleus of a mouse fertilized egg; thus obtained egg cell is cultured and then transplanted into an oviduct of a pseudopregnant female mouse; after rearing up the recipient animal, baby mice that have the above-mentioned cDNA are selected from the mice born from the recipient animal.
    Type: Grant
    Filed: September 23, 2002
    Date of Patent: September 18, 2007
    Assignee: Japan Science and Technology Agency
    Inventors: Fumitoshi Ishino, Naoki Miyoshi, Tomoko Ishino, Minesuke Yokoyama, Shigeharu Wakana