Patents Issued in October 2, 2007
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Patent number: 7276555Abstract: A method of dispersing pigment using an amide-modified resin or an amide-modified hydrocarbyl moiety, and the resulting pigment concentrate or coating or ink composition.Type: GrantFiled: May 19, 2003Date of Patent: October 2, 2007Assignee: Hexion Specialty Chemicals, Inc.Inventors: Christopher J. Holmes, Richard K. Winblad, Rudolf Anthonius Maria Venderbosch, Richard Hendrikus Gerrit Brinkhuis
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Patent number: 7276556Abstract: An aqueous suspension of cross-linked silicone particles comprising (A) cross-linked silicone particles having an average diameter of 0.1 to 500 ?m, (B) polyoxyethylene sorbitan monolaurate, and (C) water. And, in a second embodiment, an aqueous emulsion of cross-linked silicone particles comprising (A) cross-linked silicone particles having an average diameter of 0.1 to 500 ?m, (B) polyoxyethylene sorbitan monolaurate, (C) water, and (D) oil.Type: GrantFiled: May 20, 2002Date of Patent: October 2, 2007Assignee: Dow Corning Toray Silicone Co., Ltd.Inventors: Yoshitsugu Morita, Kazuo Kobayashi
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Patent number: 7276557Abstract: Resins and oligomer materials and/or combinations thereof grafted with an unsaturated acid or anhydride, such as maleic anhydride, are disclosed herein. The grafted materials are useful in adhesive formulations, particularly in hot melt adhesive applications.Type: GrantFiled: September 19, 2002Date of Patent: October 2, 2007Assignee: ExxonMobil Chemical Patents Inc.Inventors: Anne Vera Macedo, Kenneth Lewtas, John Richard Shutt
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Patent number: 7276558Abstract: Disclosed is a polymer composition comprising a copolymer of propylene, a specific amount of ?-olefin having 4 or more carbon atoms and optionally a specific amount of ethylene and a specific 1-butene homopolymer or copolymer having a melting point of not lower than 60° C. but lower than 125° C., wherein the polymer composition contains a 20° C. xylene-soluble portion of the polymer composition in an amount of from 5 to 45% by weight and the 20° C. xylene-soluble portion has an intrinsic viscosity of 1.3 dl/g or higher. The polymer composition may optionally contain a specific propylene copolymer and/or a specific propylene homopolymer or copolymer having a melting point of from 150° C. to 170° C.Type: GrantFiled: August 18, 2004Date of Patent: October 2, 2007Assignee: Sumitomo Chemical Company, LimitedInventors: Hideaki Hori, Takeshi Ebara
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Patent number: 7276559Abstract: This invention relates to a soft thermoplastic vulcanizate composition comprising: a) from about 2-10 wt %, based upon total polymer content weight a)+b)+c), of a thermoplastic polyethylene or polypropylene homopolymer, or ethylene-propylene copolymer, or copolymer that includes ethylene or propylene together with one or more C4 to C20 ?-olefins, said thermoplastic having at least 25% crystallinity by DSC; b) from about 15 to about 36 wt. %, based upon total polymer content weight a)+b)+c), of an ethylene-?-olefin random or block copolymer thermoplastic having less than 5% crystallinity by DSC; c) from about 60 to about 80 wt. %, based upon total polymer content weight a)+b)+c), of a cross-linked elastomer; and d) from about 50 to about 65 wt %, based upon total composition weight a)+b)+c)+d), of a process oil; wherein said thermoplastic vulcanizate composition has a Shore A Hardness of less than 35. The invention compositions may also comprise from about 0 to about 40 wt.Type: GrantFiled: December 15, 2004Date of Patent: October 2, 2007Assignee: Advanced Elastomer Systems, L.P.Inventors: Tonson Abraham, Kuo-Shein Shen, Norman G. Barber
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Patent number: 7276560Abstract: The present invention provides a solid golf ball comprising a hot-molded product of a rubber composition comprising (a) 100 parts by weight of a polybutadiene synthesized using a rare-earth catalyst and having a cis-1,4 content of at least 60% and a 1,2 vinyl content of at most 2%, having a viscosity ? at 25° C. as a 5 wt % solution in toluene of up to 600 mPa·s, and having Mooney viscosity (ML1+4 (100° C.)) of more than 30, (b) 0.01 to 0.5 parts by weight of a sulfur, (c) 10 to 60 parts by weight of an unsaturated carboxylic acid and/or a metal salt thereof, (d) 0.1 to 5 parts by weight of an organosulfur compound, (e) 5 to 80 parts by weight of an inorganic filler, and (f) 0.1 to 5 parts by weight of an organic peroxide, wherein the hot-molded product has a difference in JIS-C hardness between the center and surface thereof of more than 20 and up to 40. The solid golf balls of the invention have a soft feel upon impact and excellent rebound characteristics.Type: GrantFiled: December 15, 2004Date of Patent: October 2, 2007Assignee: Bridgestone Sports Co., Ltd.Inventors: Atsushi Nanba, Jun Shindo
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Patent number: 7276561Abstract: A polymer film substrate is irradiated with ions to make a large number of nano-sized through-holes and the substrate is further irradiated with an ionizing radiation so that a functional monomer is grafted or co-grafted onto a surface of the film and within the holes; in addition, the sulfonic acid group is introduced into the graft chains, thereby producing a polymer ion-exchange membrane that has high oxidation resistance, dimensional stability, electrical conductivity and methanol resistance, as well as an ion-exchange capacity controlled over a wide range.Type: GrantFiled: August 6, 2004Date of Patent: October 2, 2007Assignee: Japan Atomic Energy Research InstituteInventors: Masaru Yoshida, Tetsuya Yamaki, Masaharu Asano, Yosuke Morita
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Patent number: 7276562Abstract: An epoxy-silicone mixed resin composition to give a transparent cured product which comprises [I] 100 parts by weight of a curable resin composition containing an organosilicon compound and an epoxy resin as essential components, and [II] 0.1 to 50 parts by weight of a silicone elastomer having a refractive index within 10% of that of a cured product of the curable resin composition. It is suitable for use as an encapsulator for light-emitting semiconductors.Type: GrantFiled: April 28, 2005Date of Patent: October 2, 2007Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Tsutomu Kashiwagi, Toshio Shiobara
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Patent number: 7276563Abstract: The present invention provides a bifunctional phenylene ether oligomer compound having a thermosetting functional group at each terminal, an epoxy resin containing the above oligomer compound and a use thereof. That is, it provides a sealing epoxy resin composition for sealing an electric part, an epoxy resin composition for laminates, a laminate, a printed wiring board, a curable resin composition and a photosensitive resin composition. The resins and resin compositions of the present invention are used in electronics fields in which a low dielectric constant, a low dielectric loss tangent and high toughness are required and also used for various uses such as coating, bonding and molding.Type: GrantFiled: November 4, 2004Date of Patent: October 2, 2007Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Kenji Ishii, Yasumasa Norisue, Kiyonari Hiramatsu, Makoto Miyamoto, Makoto Yamazaki, Daisuke Ohno
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Patent number: 7276564Abstract: The present invention relates to a process for improving the start up of polymerization or copolymerization of ethylene in a gas phase reactor, preferably a fluidised bed gas phase reactor.Type: GrantFiled: July 8, 2004Date of Patent: October 2, 2007Assignee: Ineos Europe LimitedInventor: Jean-Loic Selo
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Patent number: 7276565Abstract: A process including: heating to a first polymerization temperature a first mixture including a free radical polymerizable monomer, a free radical initiator, and a stable free radical compound to polymerize only a portion of the monomer, resulting in a prepolymer composition; shearing a second mixture including the prepolymer composition, a continuous phase liquid, and a stabilizing compound to create a miniemulsion; and flowing the miniemulsion within a polymerization reactor and heating the miniemulsion at a second polymerization temperature to form polymeric particles wherein the formation of the polymeric particles occurs while the miniemulsion flows within the reactor.Type: GrantFiled: June 20, 2003Date of Patent: October 2, 2007Assignee: Xerox CorporationInventors: Thomas E. Enright, Paul D. Szabo, Barkev Keoshkerian
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Patent number: 7276566Abstract: A method for preparing a spray dried catalyst and a low viscosity, low foam spray dried catalyst system for olefin polymerization are provided. In one aspect, the method includes preparing a catalyst system including one or more components selected from metallocenes, non-metallocenes, and activators, adding mineral oil to the catalyst system to form a slurry, and adding one or more liquid alkanes having three or more carbon atoms to the slurry in an amount sufficient to reduce foaming and viscosity of the slurry. In one aspect, the catalyst system includes one or more catalysts selected from metallocenes, non-metallocenes, and a combination thereof, wherein the catalyst system is spray dried. The system further includes mineral oil to form a slurry including a catalyst system, and one or more liquid alkanes having three or more carbon atoms in an amount sufficient to reduce foaming and viscosity of the slurry.Type: GrantFiled: January 20, 2006Date of Patent: October 2, 2007Assignee: Univation Technologies, LLCInventors: Natarajan Muruganandam, Kersten Anne Terry, Michael D. Awe, John H. Oskam
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Patent number: 7276567Abstract: This invention relates to compounds represented by formula: wherein M is a group 3, 4, 5 or 6 transition, lanthanide, or actinide metal atom; E is an indenyl ligand substituted in any position with at least one aromatic or pseudoaromatic heterocyclic substituent that is bonded to the indenyl ring through a nitrogen or phosphorous ring heteroatom; A is a substituted or unsubstituted cyclopentadienyl, heterocyclopentadienyl, indenyl, heteroindenyl, fluorenyl, or heterofluorenyl ligand, or other mono-anionic ligand, or A may, independently, be E; Y is an optional bridging group; y is zero or one; X are, independently, univalent anionic ligands, and provided that when A is E, and y is one, and Y is bonded to the one position of each indenyl ligand, and per indenyl ligand there is only one aromatic heterocyclic or pseudoaromatic heterocyclic that is bonded to the indenyl ligand.Type: GrantFiled: March 11, 2005Date of Patent: October 2, 2007Assignee: ExxonMobil Chemical Patents Inc.Inventors: Alexander Z. Voskoboynikov, Artyom Y. Lebedev, Vyatcheslav V. Izmer, Alexey N. Ryabov, Mikhail V. Nikulin, Jo Ann M. Canich
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Patent number: 7276568Abstract: A copolymer of a strait chain ?-olefin and a vinyl compound (I) represented by the general formula CH2?CH—R, wherein R is a hydrocarbon group, the steric parameter Es of the substituent R is ?1.64 or less and the steric parameter B1 of the substituent R is 1.53 or more, an adhesive containing the same as an effective ingredient, and an laminate containing the adhesive.Type: GrantFiled: July 18, 2006Date of Patent: October 2, 2007Assignee: Sumitomo Chemical Company, LimitedInventors: Nobuo Oi, Akihiro Kondo, Toshiki Mori
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Patent number: 7276569Abstract: An organotellurium compound of the formula (1) is useful as a living radical polymerization initiator and makes possible precision control of molecular weights and molecular weight distributions under mild conditions wherein R1 is C1-C8 alkyl, R2 and R3 are each a hydrogen atom or C1-C8 alkyl, and R4 is aryl, substituted aryl, aromatic heterocyclic group, hydroxycarbonyl or cyano.Type: GrantFiled: August 6, 2002Date of Patent: October 2, 2007Assignee: Otsuka Chemical Co., Ltd.Inventors: Shigeru Yamago, Junichi Yoshida
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Patent number: 7276570Abstract: Golf balls comprising thermoplastic, thermoset, castable, or millable elastomer compositions are presently disclosed. These compositions comprise at least one polymer having a plurality of amide linkages and a plurality of anionic moieties attached thereto. These compositions can be used in any one or more portions of the golf balls, such as inner center, core, inner core layer, intermediate core layer, outer core layer, intermediate layer, cover, inner cover layer, intermediate cover layer, and/or outer cover layer.Type: GrantFiled: November 24, 2004Date of Patent: October 2, 2007Assignee: Acushnet CompanyInventors: Manjari Kuntimaddi, Murali Rajagopalan, Shenshen Wu
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Patent number: 7276571Abstract: A process for making phenylene dioxydiacetic acid comprises (a) contacting a dihydroxybenzene under reaction conditions with a salt of haloacetic acid in a solution without adding a haloacetic acid to produce a salt of phenylene dioxydiacetic acid; and (b) optionally converting the salt of phenylene dioxydiacetic acid to free phenylene dioxydiacetic acid. In some embodiments, 1,3-phenylene dioxydiacetic acid (RDOA) is made by reacting resorcinol with sodium chloroacetic acid in a reaction mixture with a pH in the range of about 7 to about 11 and at a temperature from about 70° C. to 105° C. By adjusting the reactions conditions, a relatively high yield of 1,3-phenylene dioxydiacetic acid (i.e., greater than 80%) is obtained. The purified acid can be used in the synthesis of polyester, such as polyethylene terephthalate.Type: GrantFiled: June 29, 2005Date of Patent: October 2, 2007Inventors: Raj B. Durairaj, Michael N. Tackie
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Patent number: 7276572Abstract: The present invention relates to novel aspartates, their method of production and the use of these mono and polyaspartates as reactive components for polyisocyanates in two-component polyurethane coating compositions and for preparing polyurethane prepolymers.Type: GrantFiled: October 3, 2003Date of Patent: October 2, 2007Assignee: Bayer MaterialScience LLCInventors: Richard R. Roesler, Edward P. Squiller, Terry D. Wayt, Brian Long
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Patent number: 7276573Abstract: The present invention provides a process for preparing mono- or diesters of polytetrahydrofuran or of tetrahydrofuran copolymers by polymerizing tetrahydrofuran in the presence of at least one telogen and/or of a comonomer over an acidic catalyst, wherein the polymerization reactor is started up using a mixture of polytetrahydrofuran, the mono- or diesters of polytetrahydrofuran and/or of the THF copolymers, tetrahydrofuran, any comonomer and at least one carboxylic acid and/or one carboxylic anhydride.Type: GrantFiled: September 4, 2003Date of Patent: October 2, 2007Assignee: BASF AktiengesellschaftInventors: Rolf Pinkos, Achim Gerstlauer, Martin Haubner, Stephan Schlitter, Stefan Käshammer, Klaus-Peter Pfaff
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Patent number: 7276574Abstract: The present invention provides a method for producing a vinyl polymer including the steps of polymerizing a vinyl monomer by atom transfer radical polymerization with a transition metal complex as a polymerization catalyst, and bringing the resultant vinyl polymer into contact with an adsorbent in the presence of an oxidizing agent; the vinyl polymer produced by the method; and a reactive composition susceptible to hydrosilylation containing the vinyl polymer produced by the method and having at least one alkenyl group per molecule.Type: GrantFiled: October 17, 2002Date of Patent: October 2, 2007Assignee: Kaneka CorporationInventors: Akihisa Hirota, Kosuke Tanaka, Shigeru Hagimori, Yosuke Asai, Naoki Furukawa, Masanao Takeda, Nao Fujita, Yoshiki Nakagawa
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Patent number: 7276575Abstract: A process for refining a crude resin for a resist which is capable of effectively removing by-products such as polymers and oligomers contained within the crude resin. The refining process for the crude resin of resist resin (A) used in a photoresist composition includes at least the resist resin (A) and an acid generator (B) dissolved in a first organic solvent (C1), such that if the concentration of the component (A) in the photoresist composition is labeled X, and the crude resin concentration of the component (A) in a crude resin solution including the crude resin of the component (A) dissolved in a second organic solvent (C2) is labeled Y, then (i) the crude resin solution is prepared so that Y is smaller than X, and (ii) the crude resin solution is subsequently filtered.Type: GrantFiled: January 29, 2004Date of Patent: October 2, 2007Assignee: Tokyo Ohka Kogyo Co., Ltd.Inventors: Hideo Hada, Takeshi Iwai, Miwa Miyairi, Masaaki Muroi, Kota Atsuchi, Hiroaki Tomida
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Patent number: 7276576Abstract: An isolated and substantially pure mammal polypeptide different from known adrenergic, serotonine and dopamine receptors, existing at least on mammalian muscle and eosinophils membranes, for instance in rat, guinea pig and humans. The invention also relates to plasmids containing the genes coding for said polypeptide, to host cells transformed by genes coding for the above mentioned polypeptide, to nucleotide probes capable of hybridizing with the genes coding for the above mentioned polypeptide, and to polyclonal and monoclonal antibodies directed against the above mentioned polypeptide.Type: GrantFiled: December 12, 1997Date of Patent: October 2, 2007Assignee: Dainippon Sumitomo Pharma Co., Ltd.Inventors: Gerlinde Lenzen, Arthur Donny Strosberg, Toshinari Sugasawa, Shigeaki Morooka
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Patent number: 7276577Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.Type: GrantFiled: April 15, 2002Date of Patent: October 2, 2007Assignee: Genentech, Inc.Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood
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Patent number: 7276578Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.Type: GrantFiled: July 1, 2002Date of Patent: October 2, 2007Assignee: Genentech, Inc.Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
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Patent number: 7276579Abstract: An immunogenic proteoliposome containing a transmembrane protein or oligomeric complexes containing such proteins, including viral envelope glycoproteins, in a lipid membrane around an elliptoid or spherical shape. The shape preferably also contains an attractant such as streptavidin or avidin and the lipid membrane contains a moiety that binds to the attractant such as biotin. The immunogenic transmembrane protein is bound to a ligand which is anchored in the shape. Methods for making the immunogenic proteoliposomes are provided uses of the proteoliposome are described, including their use as immunogens to elicit immune reaction, and their use in screening assays, including their use as antigens to screen antibody libraries, as well as for drug screening and the identification of ligands.Type: GrantFiled: December 27, 2001Date of Patent: October 2, 2007Assignee: Dana-Farber Cancer Institute, Inc.Inventors: Richard T. Wyatt, Joseph G. Sodroski, Tajib Mirzabekov, Christoph Grunder
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Patent number: 7276580Abstract: The invention relates to neublastin neurotrophic factor polypeptides, nucleic acids encoding neublastin polypeptides, and antibodies that bind specifically to neublastin polypeptides, as well as methods of making and methods of using the same.Type: GrantFiled: September 12, 2003Date of Patent: October 2, 2007Assignees: Biogen Idec MA Inc., NsGene A/SInventors: Dinah W. Y. Sah, Teit E. Johansen, Anthony Rossomando
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Patent number: 7276581Abstract: The present invention provides a mutant oligonucleotide composition encoding a cellular c-Src tyrosine kinase oncogene. Methods for isolating, expressing and characterizing recombinant Src mutant polypeptide are also provided. The invention further relates to methods for utilizing such oligonucleotides, polypeptides, agonists and antagonists for applications, which relate to research, diagnostics, and clinical arts. More specifically, this invention provides methods of diagnosing, treating, immunizing, and creating transgenic animals based on use of such mutant Src.Type: GrantFiled: July 9, 2004Date of Patent: October 2, 2007Assignee: University of South FloridaInventors: Timothy J. Yeatman, Rosalyn B. Irby
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Patent number: 7276582Abstract: Analysis of substance capable of binding with inositol-1, 4,5-triphosphate (IP3) receptor (IP3R), preferably with a regulation domain of IP3R; analysis of the function of IP3R; and establishing of a method of treatment or diagnosis for various malfunctions and diseases associated with IP3R. In particular, control of the activity of intracellular Ca2+ release. More specifically, a regulator for the activity of inositol-1,4, 5-triphosphate (IP3) receptor (IP3R), comprised of carbonic anhydrase related protein (CARP); a control agent for intracellular calsium release, comprised of carbonic anhydrase related protein (CARP); and a method of control therewith.Type: GrantFiled: November 18, 2005Date of Patent: October 2, 2007Assignee: Japan Science and Technology AgencyInventors: Katsuhiko Mikoshiba, Junji Hirota, Hideaki Ando
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Patent number: 7276583Abstract: Compositions and methods for controlling plant pests are disclosed. In particular, novel nucleic acid sequences encoding modified Cry3A toxins having increased toxicity to corn rootworm are provided. By inserting a protease recognition site, such as cathepsin G, that is recognized by a gut protease of a target insect in at least one position of a Cry3A toxin a modified Cry3A toxin having significantly greater toxicity, particularly to western and northern corn rootworm is designed.Type: GrantFiled: December 5, 2005Date of Patent: October 2, 2007Assignee: Syngenta Participations AGInventors: Eric Chen, Cheryl Stacy
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Patent number: 7276584Abstract: The invention relates to the genetic modification of plants, particularly to the expression of P-glycoprotein genes in transformed plants. Nucleotide sequences for the Br2 gene encoding a P-glycoprotein of maize and methods for their use are provided. The sequences find use in modifying the growth of plants.Type: GrantFiled: January 24, 2006Date of Patent: October 2, 2007Inventors: Gurmukh S. Johal, Dilbag S. Multani, Steven P. Briggs
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Patent number: 7276585Abstract: The present invention relates to antibody variants outside the Fc region that alter binding affinity to one or more effector ligands, methods for their generation, and their therapeutic application.Type: GrantFiled: March 24, 2005Date of Patent: October 2, 2007Assignee: Xencor, Inc.Inventors: Gregory Alan Lazar, Sher Bahadur Karki
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Patent number: 7276586Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.Type: GrantFiled: May 2, 2002Date of Patent: October 2, 2007Assignee: Genentech, Inc.Inventors: Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, William I. Wood
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Patent number: 7276587Abstract: This invention relates to mouse and human EGFH2, and to variants thereof and to polynucleotides encoding EGFH2. This invention also relates to therapeutic agents related to the polynucleotides and proteins.Type: GrantFiled: August 31, 2004Date of Patent: October 2, 2007Assignee: Chiron CorporationInventors: W. Michael Kavanaugh, Hui Cen, Pauline Lee
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Patent number: 7276588Abstract: An isolated antibody that binds to a plasminogen kringle 5 receptor, i.e., the human voltage-dependent anion channel, preferably at an epitope between amino acids Tyr224 through Lys255 thereof, is described, along with methods of use thereof. Peptides or immunogens that stimulate the production of such antibodies, along with methods of use thereof, are also disclosed.Type: GrantFiled: August 14, 2003Date of Patent: October 2, 2007Assignee: Duke UniversityInventors: Salvatore Pizzo, Mario Gonzalez-Gronow
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Patent number: 7276589Abstract: The present invention provides chimeric and humanized antibodies that specifically recognize ?5?1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.Type: GrantFiled: November 26, 2003Date of Patent: October 2, 2007Assignee: PDL Biopharma, Inc.Inventors: Vanitha Ramakrishnan, David Powers, Dale E. Johnson, Ursula Jeffry, Vinay Bhaskar
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Patent number: 7276590Abstract: The present invention relates to an ion exchange chromatography process for purifying a peptide from a mixture containing the peptide and related impurities, and to an industrial method including such ion exchange chromatography process.Type: GrantFiled: September 27, 2000Date of Patent: October 2, 2007Assignee: Novo Nordisk A/SInventor: Arne Staby
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Patent number: 7276591Abstract: The present invention relates to biomass resin composition comprising a phenolized biomass substance and a reactive substance having a melting point of at most 100° C. other than phenol. The biomass resin composition is prepared by a process, which comprises adding a reactive substance such as a phenol derivative or drying oil into the reaction system, in the step of preparing a phenolized biomass substance by phenolizing a biomass substance with a phenol in the presence of an acid catalyst. The present invention provides a biomass resin composition, in which the melting point can be freely controlled and which is excellent in properties such as flowability, processability, water resistance and impact resistance and can be prepared by a simple process, and a process for preparing the same.Type: GrantFiled: March 24, 2004Date of Patent: October 2, 2007Assignee: Fuji Carbon Co., Ltd.Inventors: Yaoguang Yao, Chuji Kitagawa, Motonobu Fujimori, Kaoru Fujimori
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Patent number: 7276592Abstract: The present invention is related to compounds comprising six-membered rings capable of being incorporated into nucleic acids. Particularly, the six-membered ring is a derivative of cyclohexane, cyclohexene, tetrahydropyran, tetrahydrothiopyran or piperidine. These compounds may be used to build up oligomeric compounds. The invention is further related to uses of these oligomeric compounds for hybridization and as probes. In addition, methods for the detection of nucleic acids are provided wherein the oligomeric compounds are used.Type: GrantFiled: April 1, 2004Date of Patent: October 2, 2007Assignee: Roche Diagnostics Operations, Inc.Inventors: Frank Bergmann, Horst Donner, Herbert Von Der Eltz, Dieter Heindl, Piet Herdewijn
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Patent number: 7276593Abstract: Disclosed are polypeptides and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.Type: GrantFiled: December 31, 2001Date of Patent: October 2, 2007Assignee: CuraGen CorporationInventors: Corine Vernet, Meera Patturajan
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Patent number: 7276594Abstract: A nucleic acid-complex, containing a nucleic acid and a positively charged, water-insoluble biodegradable polymer, is disclosed. The complex has properties of sustainedly releasing a desired nucleic acid, especially DNA, to a site. The complex can be taken up by phagocytes such as macrophages and delivered to a target site, allowing the function of the nucleic acid to be exhibited in a target specific manner.Type: GrantFiled: November 9, 2000Date of Patent: October 2, 2007Assignee: CMIC Company, Ltd.Inventors: Hidezo Mori, Yasuhiko Tabata, Kiyoshi Ando, Etsuro Tanaka, Harukazu Iseki, Hiromi Sakamoto, Naoto Fukuyama, Hirofumi Kasahara
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Patent number: 7276595Abstract: The present invention concerns a novel retinoic acid regulated gene whose expression product displays useful morphogenic/mitogenic properties. The present invention further concerns an isolated nucleic acid of SEQ ID NO:1 encoding a retinoic acid regulated expression product having an amino acid sequence of SEQ ID NO:2.Type: GrantFiled: December 2, 2003Date of Patent: October 2, 2007Assignee: Hong Kong University of Science & Technology Inc.Inventors: Nancy Y. Ip, William M. W. Cheung
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Patent number: 7276596Abstract: The present invention provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for a tissue-preferred promoter for the Zea mays gene encoding INVINH1. A method for expressing a heterologous nucleotide sequence in a plant using the promoter sequences disclosed herein is provided. The method comprises stably incorporating into the genome of a plant cell a polynucleotide operably linked to the promoter of the present invention and regenerating a stably transformed plant that expresses the linked polynucleotide.Type: GrantFiled: February 25, 2004Date of Patent: October 2, 2007Assignee: Pioneer Hi-Bred International, Inc.Inventors: Nicholas J. Bate, Odd Arne Olsen, Timothy G. Helentjaris
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Patent number: 7276597Abstract: The invention relates to nucleic acid compositions for use in sequential amplification detection assays which permit the detection of a nucleic acid target in a sample.Type: GrantFiled: November 5, 2004Date of Patent: October 2, 2007Assignee: Stratagene CaliforniaInventor: Joseph A. Sorge
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Patent number: 7276598Abstract: The present invention discloses novel phosphoramidite reagents for use in oligonucleotide synthesis. The present invention further discloses novel methods for the conversion of terminal hydroxyl groups of oligonucleotides into phosphate monoesters. By employing novel reagents, as also disclosed herein, the methods are fully compatible with standard procedures for solid phase oligonucleotide synthesis and do not require additional processing steps. The inventive reagents to phosphorylate terminal hydroxyl groups of oligonucleotides are superior to the prior art in that they for the first time combine the desired attributes of being a solid compound for facile handling, comprising two ?-eliminating protective groups removable as fast or faster than the standard cyanoethyl group, providing a DMT-group for easy monitoring of the coupling efficiency, and enabling a fast final deprotection of the phosphorylated oligonucleotide without any extra manipulation steps.Type: GrantFiled: April 9, 2004Date of Patent: October 2, 2007Assignee: Sigma-Aldrich Co.Inventors: Kurt Vagle, Michael Leuck, Andreas Wolter
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Patent number: 7276599Abstract: The invention provides for methods of manufacturing an oligonucleotide comprising a pentavalent phosphate triester. In particular, the method comprises providing a 5? blocked-nucleoside, deblocking the 5? blocked-nucleoside to form a 5? OH-nucleoside, coupling the 5? OH-nucleoside with a phosphoramidite to form and oligonucleotide comprising a trivalent phosphite triester; and oxidizing the oligonucleotide comprising a trivalent phosphite triester to the oligonucleotide comprising a pentavalent phosphate triester. In some embodiments, the wash between any of the steps above is with at least one solvent wash comprising a toluene.Type: GrantFiled: June 2, 2004Date of Patent: October 2, 2007Assignee: Isis Pharmaceuticals, Inc.Inventors: Max N. Moore, Mark Andrade, Recaldo Carty, Anthony Scozzari, Achim Krotz
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Patent number: 7276600Abstract: An optical recording medium is disclosed, which is composed of a substrate, a recording layer comprising an organic dye upon which information can be recorded by a laser beam, a reflective layer and a protective layer formed in such order; whereas the aforementioned organic dye is a substituted phthalocyanine compound chemically bonded to substituted or un-substituted ferrocene via an anhydride group and a bridge unit G, wherein said G is selected from —O—, —S—, —S—(CH2)1-6—, —(NH)—, —N(alkyl)—, —(CH2)—, —CH(alkyl)—, —C(alkyl)2—, —(CH2—O)—, —C(?O)—, —C—O—C(?O)—, —O—C(?O)—, and —C(?O)—O—.Type: GrantFiled: June 10, 2005Date of Patent: October 2, 2007Inventor: Yen Cheng Tsai
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Patent number: 7276601Abstract: A method for preparing a fused oxazinone is disclosed in which a carboxylic acid is contacted with a sulfonyl chloride and an isatoic anhydride in the presence of a tertiary amine, the nominal mole ratio of said sulfonyl chloride to said carboxylic acid being from about 1.0 to 1.5 and the nominal mole ratio of said isatoic anhydride to said carboxylic acid is from about 0.8 to 1.2.Type: GrantFiled: June 10, 2004Date of Patent: October 2, 2007Assignee: E.I. du Pont de Nemours and CompanyInventor: Eric DeGuyon Taylor
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Patent number: 7276602Abstract: The invention relates to compounds of the formula 1 or pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof, wherein wherein X, R1, and R2 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula 1.Type: GrantFiled: July 24, 2003Date of Patent: October 2, 2007Assignee: Pfizer IncInventors: Blaise Lippa, Tricia Ann Kwan, Joel Morris, Susan D. LaGreca, Matthew David Wessel
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Patent number: 7276603Abstract: Benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such compounds are disclosed. Methods of using benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such composition in the treatment and/or prevention of serotonin-related disorders, such as depression and anxiety, are also disclosed. In addition, processes for the preparation of benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives are disclosed.Type: GrantFiled: April 29, 2004Date of Patent: October 2, 2007Assignee: WyethInventors: Aranapakam Mudumbai Venkatesan, Osvaldo Dos Santos, Magda Asselin, George Theodore Grosu, Deborah A. Evrard, Richard Eric Mewshaw, Kristin Meagher
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Patent number: 7276604Abstract: The present invention relates to a crystalline, hydrated form of the sodium salt of 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid. The hydrate contains from 6.4 up to 22 weight % of sodium and 15 up to 23 weight % of crystalline water if the sodium content is lower than 7.5 weight %, based on the whole molecule, or 4.5 up to 18 weight % of crystalline water if the sodium content is equal to or higher than 13 weight %, based on the anhydrous substance. Due to stability in humid environments, the hydrate is useful as an active substance for the treatment of diseases associated with bone resorption disorders.Type: GrantFiled: October 21, 2003Date of Patent: October 2, 2007Assignee: Zentiva A.S.Inventors: Jindrich Richter, Josef Jirman