Abstract: A novel prostate tumor associated gene (designated 24P4C12) and its encoded protein is described. 24P4C12 is highly expressed in prostate tissue xenografts, providing evidence that it is turned on in at least some prostate cancers. 24P4C12 provides a diagnostic and/or therapeutic target for prostate and other cancers.

Abstract: Use of an antagonist compound of protein ESM-1 for the production of a drug for the treatment of a cancer.

Abstract: The invention relates to a novel variant of isolated and/or purified immunoglobulin IgG3 which can be used as a marker for protecting against infectious viral diseases such as AIDS, as a diagnostic tool, or as a preventive and curative medicament. The invention also relates to corresponding in vitro diagnostic methods.

Abstract: Modified chimeric polypeptides with improved pharmacokinetics and improved tissue penetration are disclosed useful for treating eye disorders, including age-related macular degeneration and diabetic retinopathy.

Abstract: A polypeptide (8F4 molecule) with a T-cell costimulating biological activity is disclosed, as well as monoclonal antibodies against the 8F4 molecule and hybridoma cells which produce the monoclonal antibodies, the use as medicaments of substances which inhibit the biological activity of the 8F4 polypeptide, in particular monoclonal antibodies, natural or synthetic ligands, agonists or antagonists, in particular for preventing or treating diseases which involve the immune system, the use of the 8F4 molecule or cells containing the 8F4 molecule as medicaments, in particular for preventing or treating diseases which involve the immune system, and the use of substances which specifically recognize the 8F4 polypeptide, in particular monoclonal antibodies, natural or synthetic ligands, agonists or antagonists, for diagnosing diseases which involve the immune system.

Abstract: Methods for treating a subject with a cancer that is characterized by overexpression of HER2 receptor protein using a combination of interleukin-2 (IL-2) or variant thereof and at least one anti-HER2 antibody or fragment thereof are provided. These anti-tumor agents are administered as two separate pharmaceutical compositions, one containing IL-2 (or variant thereof), the other containing at least one anti-HER2 antibody (or fragment thereof), according to a dosing regimen. Administering of these two agents together potentiates the effectiveness of the anti-HER2 antibody alone, resulting in a positive therapeutic response that is improved with respect to that observed with this anti-tumor agent.

Abstract: Ophthalmic compositions suitable for use as artificial tears or as vehicles for ophthalmic drugs are disclosed. The compositions contain a combination of three polymers that have a synergistic effect on viscosity.

Abstract: Recombinant plasminogen activator inhibitor-1 (PAI-1) isoforms which lack the reactive center loop and contain the complete heparin-binding domain or lack at least a portion of the heparin-binding domain are described. The rPAI-1 isoforms disclosed herein may be used to modulate angiogenesis through blocking release of VEGF from a VEGF-heparin complex. Furthermore, the rPAI-1 proteins may be used to inhibit cell proliferation and migration, induce apoptosis, and produce proteolytic fragments corresponding to angiostatin kringles 1-3 and kringles 1-4. A truncated proteolytic plasmin protein of 34 kDa is also provided.

Abstract: This invention discloses diagnostic, preventative, and treatment therapies of AIDS involving determining whether a subject exhibits an HLA-Cw7-restricted CTL response. Some methods are directed to the use of HLA-Cw7 as a genetic marker for long-term non-progression and amenability to treatment therapies. Diagnostic methods include a method for predicting long term non-progression in an HIV-infected subject. Preventative and treatment methods encompass determining whether a subject exhibits or can exhibit an HLA-Cw7-restricted CTL response. They also encompass ways of eliciting such a response, if necessary. Furthermore, some of the methods involve administering one or more HIV polypeptides or peptides, or polynucleotides encoding them, as a treatment therapy to prevent the development of AIDS.

Abstract: The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of Haemophilus influenzae (NTHi). The invention also relates to the NTHi sap operon genes and the polypeptides encoded by these polynucleotide sequences. The invention also relates to a novel 110 kDa NTHi outer membrane protein and the polynucleotide that encodes this outer membrane protein. Methods of screening for NTHi infection, and treating and preventing NTHi related disorders are also contemplated.

Abstract: In this application is the expression and purification of a recombinant Plasmodium falciparum (3D7) MSP-142. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant MSP-142 is useful as a diagnostic reagent, for use in antibody production, and as a vaccine.

Abstract: The present invention relates to a novel, isolated and purified hemorrhagic feline calicivirus FCV-DD1. The invention further embraces monovalent and multivalent vaccines containing the new FCV-DD1 strain. In addition, the invention encompasses methods of protecting felines against infection or preventing disease caused by feline calicivirus alone or in addition to other pathogens that comprises administering to the felines an immunologically effective amount of the monovalent and multivalent vaccines described herein. Also, the invention concerns methods for diagnosing or detecting the hemorrhagic feline calicivirus in a susceptible host, asymptomatic carrier and the like by detecting the presence of feline calicivirus FCV-DD1 or antibodies raised or produced against feline calicivirus FCV-DD1 antigen.

Abstract: A scrub typhus vaccine comprising truncated r47 protein and truncated r56 protein is disclosed. Vaccines composed of r56 protein variants are also disclosed. Methods of reducing HIV viral loads using r47 and r56 proteins and antibodies raised against r47 and r56 are also disclosed.

Abstract: Optically activated particles for use in cosmetic and pharmaceutical compositions are disclosed. The optically activated particles include a solid substrate having a fluorescent compound fixed thereto, and coated or encapsulated with a transparent or translucent coating of crosslinked polyvinyl alcohol. The optically activated particles absorb light at a UV wavelength and emit visible light at longer wavelengths, and are able to both absorb and scatter light in a diffuse manner in order to reduce the visual perception of skin imperfections, including cellulite, wrinkles, shadows, skin discolorations, blotchiness, and mild scars.

Abstract: The present invention provides a skin cream which can be used by most individuals on a daily basis to improve the quality of skin tone. The skin cream of the present invention comprises at least one anti-oxidant, an anti-inflammatory agent, an exfoliant, and an agent to protect against UV irradiation. In addition, the skin cream of the present invention may comprise oils, creams, and/or other compounds to promote adsorption of the active ingredients and to increase vibrancy of the skin tone. For example, in an embodiment, the skin cream of the present invention comprises: (a) dimethylaminoethanol (DMAE), (b) ?-lipoic acid, (c) lactic acid, (d) retinol, (e) zinc or titanium oxide, and (f) vitamin C, wherein components (a), (b), (c), (d), (e) and (f) are in amounts such that application of the cream to an individual increases the thickness of collagen bundles in the individual's skin.

Abstract: A packaging sheet comprising a mixture of compound A ?where R1 may be an alkyl, alkoxy or alkylene radical having 1 to 6 carbon atoms; X1 and X2, identical or different, may be hydrogen or a halogen. and compound B ?X3, X4, X5, and X6 being identical or different and selected from Cl, halogens or alkyl compounds having 1 to 6 carbon atoms or hydrogen; the particle size of the mixture being less than 10 ?m.

Abstract: A dissolvable backing layer for use with transmucosal drug delivery devices includes a dissolvable hydrophilic region and a non-hydrophilic region that inhibits or slows migration of water, drugs, other active agents, or other molecules through the backing layer. The non-hydrophilic region can be a disperse phase of gaseous voids, droplets of a hydrophobic liquid, solid particles of a hydrophobic material, or water insoluble particles that are not necessarily hydrophobic. In the alternative, the non-hydrophilic region may comprise a continuous layer or component that is readily dispersible upon dissolving of the hydrophilic region. The backing layers may be used within any transmucosal delivery device used to delivery drugs or other active agents across a mucosal surface.

Abstract: The present invention describes a means for fixing skin care ingredients on the surface of non-woven webs and cellulosic mats. The active ingredients can be released (deposited) onto the skin by normal triggering mechanisms, which include the action of water or urine or by friction or rubbing. The fixative systems described herein provide the ability to control high load levels while not interfering with the wettabliity of the fabric or paper. Additionally, incompatible/reactive ingredients can be treated onto the same web and are kept as separate particles fixed to the surface until released.

Abstract: A composition is provided comprising a substance of interest encapsulated by a continuous layer of a plurality of salt crystals which layer is impermeable to the substance of interest. Also provided is a method of producing a continuous layer of a plurality of salt crystals, the salt comprising a cation and an anion, which method comprises (i) providing a substrate which comprises a plurality of negatively charged binding sites for the cation and/or a plurality of positively charged binding sites for the anion, and (ii) contacting the substrate with a solution of the salt under conditions which cause nucleation of salt crystals comprising the cation and the anion at a plurality of said binding sites, the plurality of charged binding sites being present on the surface of the substrate at a sufficient density so that the resulting plurality of salt crystals form a continuous layer.

Abstract: Provided are processes for the preparation of compositions enriched in phenolic compounds from a crude plant extract. One process includes a novel column purification step using a polymer resin that releasably adsorbs the phenolic compounds but does not retain polar non-phenolic compounds, wherein the resin comprises aromatic rings substituted with one or more electron-withdrawing groups. This invention also includes compositions enriched in phenolic compounds. This invention encompasses methods of using the phenolic-enriched compositions for treating warm-blooded animals, including humans, infected with paramyxovaridae such as respiratory syncytial virus, orthomyoxovaridae such as influenza A, B, and C, parainfluenza, Herpes viruses such as HSV-1 and HSV-2, and Flaviviruses such as West Nile Virus, and for treating inflammation such as caused by arthritis, stress and digestive disease. The compositions are also useful as meat additives to inhibit food-borne pathogens.

Abstract: Compositions of matter comprising purified aqueous extracts of medicinal plants which are prepared by a method employing the steps of, rinsing the plant with clean water, boiling the plant in a boiler, allowing steam to escape carrying toxins from the plant, and filtering the resulting aqueous extract to produce a clear, clarified solution of the extract which has significant anti-HIV activity.

Abstract: A method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water: methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract of Piper betel by HPLC, with retention time of 3.6 and 24.0 minutes respectively, with said fractions used both individually, and in combination, and a composition comprising the said fraction nos. 1 and 9.

Abstract: The present invention provides a preferred method for preventing and/or treating a virus infection in aquatic animals, including the steps of: (i) providing a composition including trichoanguin protein; (ii) adding the composition to an aqueous solution including aquatic animals; and (iii) exposing the aquatic animals to the composition; wherein the composition is added in an amount effective to prevent and/or treat the virus infection. Preferably, the trichoanguin protein is provided by a transgenic plant.

Abstract: The invention relates to a process for producing a substantially stable dispersion without manufacturing aids, where the dispersion comprises at least one hydrophobic plant sterol and an aqueous material, wherein the plant sterol is selected from plant sterols and plant stanols. The process comprises mixing the plant sterol with the aqueous material to form a first dispersion, homogenizing the first dispersion to obtain a second dispersion of particles wherein the particle size of the hydrophobic plant sterol particles in the first dispersion and the second dispersion is from about 0.1 micron to about 100 microns. Optionally, the process may comprise heating the first dispersion prior to homogenizing, heating the second dispersion after homogenizing, or heating both. In one embodiment, the aqueous material comprises a beverage concentrate, which includes a juice concentrate, such as a citrus juice concentrate, e.g., an orange juice concentrate.

Abstract: Disclosure is made of a method for thawing frozen ground fish meats which comprises almost uniformly milling a frozen ground fish meat mass and then thawing it by elevating temperature. Disclosure is further made of a process for producing materials for fish paste products which involves the step of mixing under stirring the ground fish meat thus thawed together with additives with the use of a pin mixer. Disclosure is furthermore made of a process for producing kamaboko which comprises molding the material for fish paste products thus obtained, passing electric current therethrough, thus heating the molded products due to the electrical resistance within the same, subjecting the products to suwari gelation by heating for a definite time and then further heating the same. The method of the present invention is widely usable in the industrial fields with the use of frozen ground fish meats.

Abstract: A soy protein isolate that has increased amounts of isoflavones and saponins and a high Nitrogen Solubility Index (“NSI”) is produced by a process that involves ultrafiltration and the avoidance of isoelectric precipitation. The soy protein isolate has at least about 90.0 wt. % protein of total dry matter; an isoflavone content of at least about 1.0 mg/g isoflavones of total dry matter; a Nitrogen Solubility Index (“NSI”) of at least about 75%; and wherein a solution of about 12.0 wt. % of the soy protein isolate in water at a temperature of about 22° C. has a viscosity of less than about 500 centipoise (cp). The isolate is high in saponins and has at least 2.0 mg/g soyasapogenols. The process for producing the soy protein isolate involves removing fiber from a defatted soybean material and obtaining liquor that is subsequently pasteurized.

Abstract: Electronic devices prepared from nanoscale powders are described. Methods for utilizing nanoscale powders and related nanotechnology to prepare capacitors, inductors, resistors, thermistors, varistors, filters, arrays, interconnects, optical components, batteries, fuel cells, sensors and other products are discussed.

Abstract: CIGS absorber layers fabricated using coated semiconducting nanoparticles and/or quantum dots are disclosed. Core nanoparticles and/or quantum dots containing one or more elements from group IB and/or IIIA and/or VIA may be coated with one or more layers containing elements group IB, IIIA or VIA. Using nanoparticles with a defined surface area, a layer thickness could be tuned to give the proper stoichiometric ratio, and/or crystal phase, and/or size, and/or shape. The coated nanoparticles could then be placed in a dispersant for use as an ink, paste, or paint. By appropriate coating of the core nanoparticles, the resulting coated nanoparticles can have the desired elements intermixed within the size scale of the nanoparticle, while the phase can be controlled by tuning the stochiometry, and the stoichiometry of the coated nanoparticle may be tuned by controlling the thickness of the coating(s).

Abstract: A method for preparing a metal nanocluster composite material. A porous zeolitic material is treated with an aqueous metal compound solution to form a metal ion-exchanged zeolitic material, heated at a temperature ramp rate of less than 2° C./min to an elevated temperature, cooled, contacted with an organic monomer and heating to induce polymerization, and heating the composite material to greater than 350° C. under non-oxidizing conditions to form a metal nanocluster-carbon composite material with nanocluster sizes between approximately 0.6 nm and 10 nm.

Abstract: A synthetic leather is made by a impregnating a non-woven or woven textile with an aqueous polyurethane dispersion comprised of a nonionizable polyurethane and an external stabilizing surfactant. The impregnated textile is then exposed to water containing a coagulant for a coagulation time sufficient to coagulate the dispersion. The method may be used to form a synthetic leather having excellent wet ply adhesion and may contain an insoluble multivalent cation organic acid.

Abstract: A method for making a ceramic matrix composite turbine engine component, wherein the method includes providing a plurality of biased ceramic plies, wherein each biased ply comprises ceramic fiber tows, the tows being woven in a first warp direction and a second weft direction, the second weft direction lying at a preselected angular orientation with respect to the first warp direction, wherein a greater number of tows are woven in the first warp direction than in the second weft direction. The plurality of biased plies are laid up in a preselected arrangement to form the component, and a preselected number of the plurality of biased plies are oriented such that the orientation of the first warp direction of the plies lie about in the direction of maximum tensile stress during normal engine operation. A coating is applied to the plurality of biased plies. The coated component preform is then densified.

Abstract: A machine and process for a pattern, such as a submicron grating pattern onto a substrate.

Abstract: The present invention is directed towards a ceramic nanocomposite comprising a nanostructured carbon component inside a ceramic host. The ceramic nanocomposite may further comprise vapor grown carbon fibers. Such nanostructured carbon materials impart both structural and thermal barrier enhancements to the ceramic host. The present invention is also directed towards a method of making these ceramic nanocomposites and for methods of using them in various applications.

Abstract: A plasma reactor has a reactor vessel and a pair of electrodes in the form of spaced apart and oppositely disposed metallic surfaces defining therebetween a plasma discharge space. At least one of the metallic surfaces is the surface of a metallic plate having a plurality of gas feed openings extending through the metallic surface towards said discharge space and from a distribution chamber extending along the plate opposite the discharge space. The distribution chamber has a wall opposite and distant from the plate and includes a gas inlet arrangement with a plurality of gas inlet openings distributed along the wall and connected to one or more gas feed lines to the reactor. A gas flow resistant coefficient between the one or more gas feed lines and at least a predominant portion of the connected inlet openings are at least substantially equal.

Abstract: In order to improve the energy balance of an HID lamp, the quartz burner, preferably the inside thereof, is coated with a UV reflecting layer system by alternatingly applying amorphous thin layers made at least of titanium oxide and silicon oxide having the respective general stoichiometry TiOy and SiOx by means of a plasma impulse chemical vapor deposition (PICVD) method at a high power density and increased substrate temperatures ranging from 100° to 400° C., using small growth rates ranging from 1 nm/sec to 100 nm/sec so as to form an interference layer system having a thickness of less than 1200 nm and a minimized UV-active defective spot rate ranging from 0.1 to 1 percent.

Abstract: Liquid crystal composition having negative dielectric anisotropy include a first component having at least two compounds represented by at least two formulas selected from formulas (1-1) to (1-6) in the range of 20 to 75% by weight based on the total weight of the liquid crystal composition, and a second component having at least one compound selected from the group of the compounds represented by formulas (2-1) to (2-3) in the range of 25 to 75% by weight based on the total weight of the liquid crystal composition:

Abstract: A manufacturing method of a cellulose ester film satisfying the relationships, Nx>Ny>Nz, and 0.8?Rt/R0?3.5, the method comprising casting a cellulose ester dope containing a solvent of a good solvent and a poor solvent on a support to form a web; peeling the web from the support; transporting the peeled web (step D0); holding the edges in the transverse direction of the web (step A); stretching the resulting web in the transverse direction while applying a tension; reducing the tension in the transverse direction of the web; and drying the stretched web, wherein the residual solvent content of the web is 5 to 90% by weight at the beginning in the step A, and the residual poor solvent content in the residual solvent content of the web is from 15 to 95% by weight at the terminal point in the Step D0.

Abstract: Structure comprising at least two glass substrates (10, 11) separated by a distance (i), at least one substance (12) at least partly filling the space between the two substrates, and spacers (13) placed between the two substrates in order to maintain their spacing, characterized in that the spacers (13) are fastened to at least one of the substrates.

Abstract: A heat-insulating container having a first fiber layer (111) with a prescribed density and a second fiber layer (112) which is formed inside the first fiber layer (111) and has a lower density than the first fiber layer (111). The first fiber layer (111) is 0.2 to 1 mm thick, and the second fiber layer (112) is 0.4 to 3 mm thick, with the total thickness of the first fiber layer (111) and the second fiber layer (112) being 0.6 to 4 mm.

Abstract: The present invention relates to a thermo-shrinkable polyester film with a superior thermal shrinkage, which has an orientation angle of a molecular chain in a range of from 0° to about ±10° relative to a main shrinkage direction, and a molecular orientation ratio (MOR) in a range of from 1.29 to about 2.5, thereby preventing a label made from the film from curling or waving.

Abstract: A black pigmented disposable food container is preferably made from a polypropylene matrix polymer, optionally including polyethylene and further includes a mineral filler and a black colorant composition consisting essentially of a black iron oxide pigment and a green pigment.

Abstract: An ovenable package contains an ovenable product and has a display surface mounting a self-adhesive ovenable label, for example, presenting a coupon or other product promotional item. The ovenable label has at least two layers including a promotional layer defining the text and graphics of the promotional item. The promotional layer can be paper covered by a transparent, heat resistant barrier layer, preferably made of polyester, adhered to the ovenable package directly or to a heat resistant base layer which is adhered to the ovenable package. In this case, one or more layers of the label can be perforated to define a lift off section. Or, the promotional layer itself can be the outer heat resistant layer releasably adhered to the base layer. A labeling method of providing the promotional item to a consumer of the ovenable product is also disclosed.

Abstract: A synthetic grass assembly for installation on a supporting soil substrate includes a pile fabric with a flexible sheet backing and rows of upstanding synthetic ribbons representing grass blades, extending upwardly from an upper surface of the backing. An infill layer of two distinct graded courses of particulate material is disposed interstitially between the upstanding ribbons upon the upper surface of the backing and of a depth less than the length of the ribbons. A bottom course of intermixed hard sand and resilient rubber granules with substantially identical particle size distribution characteristics is installed upon the backing and a top course exclusively of resilient rubber granules is placed upon the bottom course.

Abstract: The core mold in the molding device (51) for forming the molded member (4) of the weather strip (1) is provided with a center core (61) having a center core body (63), and a side core (62) having a pair of side core bodies (66L, 66R) The base bottom portion (21) of the molded member (4) is made so that a center slit (33) having substantially an H-shape, a pair of slide slits (32L, 32R), and slit-less bridge portion (34). In order to open the molds, the side core (62) is slid, and the center core body (63) is thereby separated from the side core bodies (66L, 66R). The center core body (63) is thereby withdrawn from the weather strip (1), and the side core bodies (66L, 66R) thereafter are withdrawn.

Abstract: The invention relates to a flat needle-punched non woven of natural and/or synthetic fibers having a weight per unit area within a range of from 200 to 1600 g/m2, characterized in that one tenth to one hundredth of at least one of the two main surfaces has a surface coating in the form of a pattern.

Abstract: A novel polytetrafluoroethylene (PTFE) material includes a plurality of aggregates connected together by a plurality of relatively long fibrils. Each of the aggregates are formed of PTFE nodes that are connected together by relatively short fibrils. Preferably, the long fibrils have lengths of 500 to 1000 microns and the short fibrils have a lengths of 10 to 30 microns. The aggregates have densities of less than 2.0 grams per cubic centimeter which is lower than the densities of the solid PTFE nodes which have densities of about 2.0 to 2.2 grams per cubic centimeter.

Abstract: The present invention relates to the use for coating three-dimensionally structured surfaces and/or moldings of melamine resin sheets and/or films produced from cellulosic fiber materials post- or pre- and post-impregnated with an aqueous solution comprising (i) a melamine-formaldehyde condensate, (ii) an etherified melamine-formaldehyde condensate, and (iii) a polymer dispersion.

Abstract: A linoleum-based planar structure, a process for the preparation of such a planar structure as well as the use of the planar structure, for example, as a floor covering is provided. The linoleum-based planar structure contains flakes, including organic polymeric material, over the whole cross section of the linoleum sheet. The flakes are compatible with the linoleum base composition and have a particle size in the range of 0.5 mm to 30 mm and a thickness in the range of 1.0 ?m to 400 ?m. Such a planar structure displays a smooth plain surface without the need of any grinding step. Moreover, the incorporation of such flakes enables a broad variety of designing and patterning, particularly the development of a distinctively, coarsely patterned “spotting structure.

Abstract: This invention relates to labels. In one embodiment, the labels comprise (A) a polymer film comprising a styrenic polymer, said film having an upper surface and a lower surface, and an MVTR of from about 15 to about 150 g/m2/day, and (B) a water-based adhesive in contact with the lower surface of the film. These labels can be bonded to substrates of glass, plastic or metal using the water based adhesive.

Abstract: Nanoscale particles, particle coatings/particle arrays and corresponding consolidated materials are described based on an ability to vary the composition involving a wide range of metal and/or metalloid elements and corresponding compositions. In particular, metalloid oxides and metal-metalloid compositions are described in the form of improved nanoscale particles and coatings formed from the nanoscale particles. Compositions comprising rare earth metals and dopants/additives with rare earth metals are described. Complex compositions with a range of host compositions and dopants/additives can be formed using the approaches described herein. The particle coating can take the form of particle arrays that range from collections of disbursable primary particles to fused networks of primary particles forming channels that reflect the nanoscale of the primary particles. Suitable materials for optical applications are described along with some optical devices of interest.