Abstract: A pharmaceutical composition for the prophylaxis or treatment of glaucoma which comprises an angiotensin II antagonist and at least one compound selected from an adrenaline receptor blocker, a prostaglandin and a carbonic anhydrase inhibitor; and a method for the prophylaxis or treatment of glaucoma by administering the composition to a patient.

Abstract: Pyrazole derivatives are described herein. The described invention also includes methods of making such pyrazole derivatives as well as methods of using the same in the treatment of diseases.

Abstract: An indole derivative represented by the following general formula (1): wherein at least one of R1, R2, R3, and R4 represents an alkoxy group containing 1 to 20 carbon atoms, and other groups of the R1, R2, R3, and R4 represent hydrogen, an alkyl group containing 1 to 6 carbon atoms, acetyl group, or hydroxyl group; and either one of X and Y represents —(CH2)nOH wherein n is an integer of 0 to 30, and the other one of the X and Y represents hydrogen atom; or a salt thereof; and a drug and an agent for promoting differentiation of a stem cell containing such indole derivative or its salt as an effective component, wherein the indole derivative (1) has action of inducing differentiation of neural stem cell specifically into a neuron, and this indole derivative is useful as a prophylactic or therapeutic drug for brain dysfunction or neuropathy caused by loss or degeneration of the neuron.

Abstract: This invention pertains to certain 4-(1-(sulfonyl)-1H-indol-2-yl)-4-(hydroxy)-cyclohexa-2,5-dienone compounds, and analogs thereof, including compounds of the following formula, which are, inter alia, antiproliferative agents, anticancer agents, and/or thioredoxin/thioredoxin reductase inhibitors: formula (I) wherein: Ar is a 1-(sulfonyl)-1H-indol-2-yl group; the bond marked ? is independently: (a) a single bond; or: (b) a double bond; the bond marked ? is independently: (a) a single bond; or: (b) a double bond; the group —ORO is independently: (a) —OH; (b) an ether group (e.g., —OMe); or: (c) an acyloxy (i.e., reverse ester) group (e.g.

Abstract: Novel compounds of the formula I in which R, X, n and m are as defined herein are inhibitors of tyrosine kinase and can be employed for the treatment of tumours, for neuroprotection and for protection of the stress proteins of the skin.

Abstract: A method for treating cerebral vascular diseases in a human or non-human animal is disclosed. The method involves inhibiting 20-HETE synthesizing enzyme activity sufficiently to increase or prevent a decrease in cerebral blood flow in the human or non-human animal.

Abstract: The present invention relates, in general, to the treatment of estrogen-dependent diseases and disorders and, in particular, to a method of treating estrogen-dependent cancers, particularly breast cancer, with antiestrogens.

Abstract: An antiseptic composition useful in destroying the infectivity of infectious proteins such as prions is disclosed. The antiseptic composition is preferably maintained at either a low pH of 4.0 or less or a high pH of 10.0 or more either of which allows for an environment under which the active component (which is preferably sodium dodecyl sulfate) destroys infectivity. The composition may be added to blood, blood products, collagen, tissues and organs prior to transplantation. The composition also may be added to livestock feed to denature any prions in the livestock. Methods of denaturing infectious proteins are also disclosed which method can use but do not require higher temperatures and long period of exposure.

Abstract: The disclosed invention relates to a process for making an emulsion. The process comprises: flowing a first liquid through a process microchannel, the process microchannel having a wall with an apertured section; flowing a second liquid through the apertured section into the process microchannel in contact with the first liquid, the first liquid forming a continuous phase, the second liquid forming a discontinuous phase dispersed in the continuous phase.

Abstract: A blowing agent blend for making thermoplastic polymer foams comprises methyl formate. The blowing agent blend can further comprise at least one co-blowing agent. The co-blowing agent is either a physical co-blowing agent (e.g. an inorganic agent, a hydrocarbon, a halogenated hydrocarbon, a hydrocarbon with polar, functional group(s), water or any combination thereof), or a chemical co-blowing agent, or combinations thereof. The thermoplastic polymer foam can be an alkenyl aromatic polymer foam, e.g. a polystyrene foam. The blowing agent blend can comprise 100 mol % methyl formate, or it can comprise any combination of methyl formate and one or more co-blowing agents. The methyl formate-based blowing agent blends produce stable foams. A process for the preparation of such foams is also provided.

Abstract: A curable composition is described comprising a Michael donor component, a polyacryl component, and a monoacryl component, where at least one of the Michael donor or monoacryl components comprises a pendent photoinitiator group. A Michael addition polymer that is the Michael addition reaction product of these components is also described.

Abstract: A photopolymerizable composition comprising a polymerizable compound and a photopolymerization initiator, wherein the polymerizable compound is characterized by comprising (a) a bifunctional (meth)acrylic acid (thio)ester compound containing a sulfur atom in the molecule and (b) at least one of a (meth)acrylic acid ester compound represented by the general formula (1) or a bifunctional (meth)acrylic acid ester compound having a urethane linkage: wherein R1 and R2 are each independently a hydrogen atom or a methyl group; R3 and R4 are each independently an alkyl group, an aralkyl group, an aryl group or a halogen atom; m and n are each an integer of 0 to 2; X1 is an alkylidene group having 1 to 3 carbon atoms; and Y1 and Y2 are each independently a poly(oxyalkylene) group with the proviso that at least one of Y1 and Y2 is a poly(oxyalkylene) group having a hydroxy group.

Abstract: Cellulosic or lignocellulosic materials, and compositions and composites made therefrom, are disclosed.

Abstract: An ink jet recording ink (IJ ink) containing a colorant of a pigment and/or dye enveloped in a polymer, and water, and containing at least one compound from the group of acetylene glycol surfactants and acetylene alcohol surfactants, and another compound from the group of glycol ethers and 1,2-alkylene glycols; an IJ ink set including a plurality of the inks; a recording method of using the ink and/or the ink set; recorded matter printed according to the recording method; and an ink jet recording apparatus having an electrostrictive unit mounted thereon and designed so as to be capable of ejecting the ink.

Abstract: Disclosed is a water-based pigment ink composition comprising, as colorants, (1) a surface treated pigment having a water-dispersibility imparting group introduced to the surface thereof and (2) a water-dispersible polymer-encapsulated pigment which is a pigment wholly coated with a polymer. The water-based ink composition exhibits good color developability and satisfactory abrasion resistance, causes little blurring, and has excellent storage stability.

Abstract: Polymer particles comprising a cross-linked polymer core and a linear non-cross-linked polymer shell may be formed by emulsion polymerization. The polymer particles may be used in forming toner.

Abstract: The present invention relates to an electrical component, which has an electrically conductive composition that is stable at high temperatures, and includes a partially pyrolized carbon based powder filler and a host matrix. The present invention also relates to an electrophotographic system which further is stable at conventional ambient environmental use conditions, such as different humidity levels and/or ambient temperature ranges.

Abstract: The present invention provides for a composition and a process for forming the composition. The composition comprises an organic polymer and 0.

Abstract: A polycarbonate resin composition for use in the production of a substrate for an optical information medium, comprising (A) an aromatic polycarbonate resin having a weight average molecular weight of from 13,000 to 18,000, wherein the aromatic polycarbonate resin (A) is produced by subjecting an aromatic dihydroxy compound and a carbonic diester to a transesterification reaction, and is substantially free of a chlorine atom; and (B) a partial ester obtained from a saturated aliphatic carboxylic acid having 10 to 30 carbon atoms and a di- to hexahydric alcohol, wherein the partial ester (B) has an acid value of from 2 to 20 mgKOH.

Abstract: A pressure sensitive adhesive comprised of P(A)-P(B)-P(A) block copolymers, wherein P(A) has a glass transition temperature of 0° C. or below, P(B) has a glass transition temperature of 20° C. or above, and P(A) and P(B) are immiscible.

Abstract: To provide a rubber composition for breaker having balanced properties among rigidity, heat resistance, adhesiveness, humid aging adhesion and elongation, and a pneumatic tire having a breaker layer or a belt layer comprising the rubber composition. A rubber composition for breaker comprises 55 to 65 parts by weight of carbon black, 5 to 15 parts by weight of silica, 3.5 to 4.5 parts by weight of sulfur, at least 0.08 part by weight of cobalt, a resorcinol resin and a methylene donor based on 100 parts by weight of a rubber component containing a natural rubber and/or an isoprene rubber as a main component.

Abstract: In this method for making a sintered reactive material, fuel particles are blended with a polymer matrix comprising at least one fluoropolymer in an inert organic media to disperse the fuel particles in the polymer matrix and form a reactive material. The reactive material is dried and pressed to obtain a shaped preform, which is sintered in an inert atmosphere to form the sintered reactive material. By sintering in an inert atmosphere, the sintered reactive material may include reactive metals and/or metalloids in a nonoxidized state. The resulting sintered reactive material preferably has a tensile strength in excess of 1800 psi and an elongation at break in excess of 30%.

Abstract: The present invention provides compositions that feature improved preferential adhesion and release characteristics with respect to a substrate and a mold having imprinting material disposed therebetween. To that end, the compositions facilitate bifurcation of the imprinting into a surfactant-component-rich sub-portion and a surfactant-component-depleted sub-portion located between said surfactant-component-rich sub-portion and said substrate. This surfactant-component-rich sub-portion attenuates the adhesion forces between the mold and the imprinting material, once solidified.

Abstract: The present invention is directed to a thin film material for encapsulation of organic or polymeric light-emitting electric device having light-emitting layer between cathode and anode, for elongation of lifetime of said device and for providing said device with flexibility, more specifically, to a thin film material for encapsulation of organic or polymeric light-emitting electric device comprising polymer having, as repeating unit of backbone, homo-, 2-component co-, ter-, or tetra-polymer of one to four pentaerythritol acrylate monomer, or physically mixed polymer blend of said polymer and polymers other than poly(pentaerythrithol acrylate). Moreover, the present invention is directed to a method for encapsulation of organic or polymeric light-emitting device using said thin film material consisting of wet and dry process. The light-emitting device encapsulated according to the present invention can be bended and can be used in the manufacturing of large surface area display.

Abstract: The present invention provides a thermoplastic resin composition containing 100 parts by mass of a mixture of a thermoplastic resin (A) and carbon nanotubes (B), the mixture being composed of the component (A) in an amount of 20 to 99.95 mass % and the component (B) in an amount of 0.05 to 20 mass %; a flame retardant (C) in an amount of 0.05 to 30 parts by mass; and a polyfluoroolefin resin in an amount of 0 to 2 parts by mass. The flame retardant is preferably a phosphorus compound, and the thermoplastic resin preferably contains, as a component, an aromatic polycarbonate-polyorganosiloxane copolymer.

Abstract: This invention discloses a method for preparing rubber compositions that exhibit unique combinations of properties that are desirable for tire tread applications for enhanced snow/ice and wet traction, low rolling resistance and increased treadwear performance in comparison with conventional silica compounds. Specifically, a high reactively silane coupling agent, such as a mercaptosilane, is used in combination with a silane coupling typically used for silica tread compounds such as bis(triethoxylsilylpropyl)disulfide to treat silica pellets in a hydrocarbon solvent at elevated temperatures. The treated silica is then blended with solution elastomer cement in a hydrocarbon solvent. The deposited reactive silanes partially react with the elastomer molecules forming a layer of polymer grafted on the silica surfaced. This structure significantly improves the silica retention during the steam stripping operation. Almost 100% (99+%) silica retention has been achieved by this invention.

Abstract: A silicone rubber coating composition which cures into a silicone rubber having a tear strength of 25-50 kN/m and a peeling bond strength of 30-60 N/cm is suited for coating of hollow weave type air bags. A hollow weave type air bag coated with the coating composition can be instantaneously inflated while the bag prevents the silicone rubber film from being peeled from the base fabric, eliminates inflating gas leakage, and retains an acceptable inflation time.

Abstract: A photocurable composition, including (a) a photocurable monomer, e.g. a cationically curable monomer and/or a radically curable monomer; (b) reactive particles comprising a crosslinked elastomeric core, e.g. made of polysiloxane material, and a shell of reactive groups on an outer surface of the core, wherein the reactive groups comprise epoxy groups, ethylenically unsaturated groups, or hydroxy groups; and (c) an appropriate photoinitiator, e.g. a radical photoinitiator; and a cationic photoinitiator. A method of making a 3-D object from such a composition and a 3-D object made by the method are also provided. The cured composition generally has a smooth surface. The use of the reactive particles makes the composition more stable and the particles do not readily separate out.

Abstract: Hot-melt adhesive compositions used in non-woven assemblies, comprising: (a) 100 parts by weight of a block copolymer of the formula S-(I/B)-S, wherein S represents a predominantly poly(styrene) block and (I/B) represents a polymer block obtained by at random copolymerization of a mixture of predominantly isoprene and butadiene in a weight ratio in the range of from 70:30 to 30:70, wherein the total block copolymer has a melt flow index measured at 200° C./5 kg in the range of from 0.1 to 12 g/10 min. and has a poly(styrene) content of from 28 to 50 wt % and a coupling efficiency of from 50 to 100%, (b) from 250 to 300 parts by weight of a tackifying resin, (c) from 50 to 150 parts by weight of a plasticizer, and (d) from 0 to 3 parts by weight of auxiliaries, such as stabilizers and/or antioxidants, and disposable articles, comprising at least a non-woven element and assembled by the use of said hot-melt adhesive compositions.

Abstract: A thermoplastic polymer composition that exhibits substantially isotropic post injection molding shrinkage. The thermoplastic polymer composition includes a blend of highly crystalline polypropylene homopolymer, an ethylene-C4-8 ?-olefin plastomer and talc having a D50 of about 2.0 ?m or less. The thermoplastic polymer composition exhibits post injection molding shrinkage, low temperature impact strength and tensile strength that is similar to or better than relatively expensive engineering resins and blends. The thermoplastic polymer composition according to the invention is particularly useful for forming injection molded parts for motor vehicles.

Abstract: Polyethylene blend compositions suitable for rotomolding, rotomolded articles, and processes for rotomolding articles are provided. The polyethylene compositions include a first polyethylene having a melt index of 0.4 to 3.0 g/10 min and a density of from 0.910 to 0.930 g/cm3; and a second polyethylene having a melt index of 10 to 30 g/10 min and a density of 0.945 to 0.975 g/cm3. The composition has a density of from 0.930 to 0.955 g/cm3 and a melt index of 1.5 to 12 g/10 min, and the first and second polyethylenes differ in density by from 0.030 to 0.048 g/cm3. These compositions exhibit improved physical properties, such as Environmental Stress Crack Resistance and Izod Impact Strength.

Abstract: A block copolymer composition AB is provided that has pendent groups —RZ extending from the A copolymer on at least 70 mol % of the A monomers, where R and Z are each an ionic species. The composition is included in a semipermeable membrane for use in a direct methanol fuel cell. Also described are articles of protective apparel comprising the composition which advantageously has barrier properties as well as superior water vapor transport properties.

Abstract: The present invention relates to an epoxy compound, represented by a general formula (I), which is solid at ordinary temperature, has extremely low melt viscosity and has excellent curing property and which can provide a cured product which is excellent in mechanical strength, heat resistance, and moisture resistance. It also relates to a preparation method of the epoxy compound, an epoxy resin composition, and a cured product thereof. The epoxy compound is represented by the following general formula (I): (wherein R1-R10 each represent hydrogen atom or alkyl group having 1-6 carbon atoms, and n represents an integer of 0 or more).

Abstract: A method of preparing a latex that includes pigments copolymerized with a crystalline polymer includes: dispersing a pigment and a dispersing agent in water having an ultra-high purity to obtain a pigment dispersion; dissolving a crystalline monomer in a basic monomer mixture to obtain an organic phase; dissolving while heating the dispersing agent in water having an ultra-high purity, and then mixing the solution with the pigment dispersion to obtain an aqueous phase; mixing and agitating the organic phase and the aqueous phase to obtain a homogenized solution; agitating and heating the homogenized solution; adding a polymerization initiator to the homogenized solution to be reacted; and cooling the reaction solution to room temperature.

Abstract: The present invention relates to a catalyst composition and a method for making the catalyst composition of a polymerization catalyst and a static charge modifier. The invention is also directed to the use of the catalyst composition in the polymerization of olefin(s). In particular, the polymerization catalyst system is supported on a carrier. More particularly, the polymerization catalyst comprises a bulky ligand metallocene-type catalyst system.

Abstract: A fluorine-containing allyl ether polymer having a number average molecular weight of 1,000 to 1,000,000 and consisting of chains of at least one repeating unit of the formula: wherein A is an organic group having 1 to 100 carbon atoms.

Abstract: This invention relates to a process for preparing a low-odor hydrogel-forming acrylic acid polymer, which comprises the steps of: a) preparing a polymeric hydrogel by free-radically polymerizing a monomer composition comprising at least 50% by weight of acrylic acid in an aqueous polymerization medium and converting said hydrogel into a particulate hydrogel or into hydrogel-forming powder; and optionally b) treating said particulate hydrogel or said hydrogel-forming powder with a crosslinking substance which, actually or latently, contain at least two functional groups capable of reacting with the carboxyl groups on the addition polymer; characterized by the acrylic acid used in step a) containing less than 400 ppm of acetic acid and propionic acid. It further relates to the hydrogel-forming addition polymers obtainable by the process and to their use.

Abstract: Methods of polymerizing at least one olefin include contacting the olefin with a catalyst comprising chromium and with a cocatalyst comprising a non-transition metal cyclopentadienyl (Cp) compound. The polymerization may be performed in the presence of hydrogen. Using the cocatalyst in conjunction with the catalyst increases several properties, such as the high load melt index (HLMI), the MW, and the MN, of the polymers produced by this polymerization method. Polymer compositions produced by such methods have various unique properties, including a PDI greater than about 30. Additional embodiments include articles of manufacture or end use articles formed from such polymer compositions.

Abstract: This invention relates to silylated polymers having mixed alkoxy groups on the silyl portion thereof, methods of their preparation, and compositions and reaction products formed therefrom. These alkoxysilylated polymers can be crosslinked when exposed to atmospheric moisture to become useful elastomers, sealants or adhesives. The presence of different alkoxy groups on the silicon atoms can control or otherwise moderate the cure speeds of these silylated polymers.

Abstract: A high-reactivity liquid polyurethane composition which contains at least one uretdione group and cures at a low baking temperature can be used for producing plastics, particularly surface coatings and adhesives. The polyurethane composition contains A) at least one curing agent which contains at least one uretdione group and is obtained from i) an aliphatic polyisocyanate, a (cyclo)aliphatic polyisocyanate, a cycloaliphatic polyisocyanate or mixtures thereof, and ii) at least one hydroxyl-containing compound, the curing agent having a free NCO content of less than 5% by weight and a uretdione content of from 1 to 18% by weight; and B) at least one catalyst.

Abstract: A polyisocyanate-based elastomer having a ratio of the storage modulus (E?) at 20° C. and the storage modulus (E?) at 120° C. of between 0.75 and 1.5, a tan ? at 100° C. of less than 0.1 and a maximum value of the tan ? of more than 0.8, the tan ? being the ratio of the loss modulus (E?) and the storage modulus (E?).

Abstract: The present invention is directed to low dielectric polymers and to methods of producing these low dielectric constant polymers, dielectric materials and layers, and electronic components. In one aspect of the present invention, an isomeric mixture of thermosetting monomers, wherein the monomers have a core structure and a plurality of arms, is provided, and the isomeric mixture of thermosetting monomers is polymerized, wherein polymerization comprises a reaction of an ethynyl group that is located in at least one arm of a monomer.

Abstract: A sulfonated aromatic polyether ketone of the formula (II) [Ar—O—Ar?—CO—Ar?—O—Ar—CO—Ar?—CO—] ??(II) in which from 1% to 100% of the O-phenylene-CO units are substituted with an SO3M group and sulfonated and unsulfonated O-phenylene-CO units can be in any desired sequence with respect to one another, the radicals Ar, Ar? and Ar? independently of one another are substituted or unsubstituted 1,2-, 1,3- or 1,4-phenylene rings, and M, taking into account the ionic valencies, comprises one or more elements selected from the following group: H, NR4+, where R is H or C1-C4-alkyl, or an alkali metal or alkaline earth metal or a metal from subgroup 8, and is preferably H, NR4+, Li, Na, K, Ca, Mg, Fe or Pt.

Abstract: Disclosed herein are a novel diamine compound having a dendron side chain and a liquid crystal alignment material produced using the diamine compound. Specifically, the diamine compound is used to prepare a polyamic acid, which is then used to produce the liquid crystal alignment material. According to the liquid crystal alignment material, the pretilt angle of a liquid crystal is easy to control, and the alignment properties of a liquid crystal are good. Particularly, since the liquid crystal alignment material shows superior chemical resistance to washing solvents used in LCD panel fabrication processes, it has an advantage in that the alignment properties of a liquid crystal are not degraded even after washing.

Abstract: The present invention relates to novel polyaspartimides, their method of production and the use of these polyaspartimides as reactive components for polyisocyanates in two-component polyurethane coating compositions. The polyaspartimides are prepared by reacting a polyether amine with a maleimide.

Abstract: Methods and apparatus for measuring and/or controlling the temperature on the surface or inside of micro chips are provided, including using thermally responsive polymers.

Abstract: The invention relates to synthetic leptin antagonists in which at least two amino acid residues of the sequence LDFI/S of the hydrophobic binding site at positions 39-42 of a leptin polypeptide sequence are substituted with different amino acid residues such that the site becomes less hydrophobic, and fragments of said leptin antagonists.

Abstract: The invention relates to a new method for combating tumor illnesses through the use of molecular biological associations during formation of the tumor. The aim of the invention is to develop a method for controlling the regulation of ?-catenine in body cells. The object of the invention is a new protein which bonds to ?-catenine and the subsequent cytoplasmic decomposition of said protein. This protein has the amino-acid sequence according to FIG. 1 and is designated as conductine. Agents for diagnosing and treating tumor illnesses are developed from the occurrence and the action of conductine in body cells.

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Abstract: The invention provides a sodium independent transporter which transports a small-sized neutral amino acid and its analog; its gene; fused proteins; and a method of analyzing the function of the transporter. Further provided is a use for the transporters as described by the invention.