Patents Issued in January 15, 2008
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Patent number: 7319109Abstract: The invention relates to a compound of formula (I): wherein all variables are as defined herein and to pharmaceutical compositions, methods of using, and processes for preparing the same.Type: GrantFiled: November 12, 2003Date of Patent: January 15, 2008Assignee: Smith Kline Beecham CorporationInventors: Sharon D Boggs, Jon L Collins, Stephen M Hyatt, Patrick R Maloney
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Patent number: 7319110Abstract: The present invention relates to a group of 1H-1,2,4-triazole-3-carboxamide derivatives, to methods for the preparation of these compounds, and to pharmaceutical compositions containing at least one of these compounds as an active ingredient. These 1H-1,2,4-triazole-3-carboxamide derivatives are potent cannabinoid-CB1 receptor agonists, partial agonists, inverse agonists or antagonists, useful for the treatment of disorders involving cannabinoid neurotransmission. The compounds have the general formula (I) wherein R and R1-R3 have the meanings given in the specification.Type: GrantFiled: September 16, 2003Date of Patent: January 15, 2008Assignee: Solvay Pharmaceuticals B.V.Inventors: Josephus H. M. Lange, Cornelis G. Kruse, Andrew C. McCreary, Herman H. van Stuivenberg
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Patent number: 7319111Abstract: The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.Type: GrantFiled: February 18, 2004Date of Patent: January 15, 2008Assignee: Encysive Pharmaceuticals, Inc.Inventors: Daxin Gao, Robert Market, Chengde Wu
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Patent number: 7319112Abstract: The present invention provides antibacterial compounds, antibacterial compositions, bacteria-reducing methods, bacteria-reduced substrates/articles made by the methods that employ an antibacterial agent comprising a non-halogenated nitrile-substituted salicylanilide, and processes for producing 5-acyl salicylamides.Type: GrantFiled: September 15, 2003Date of Patent: January 15, 2008Assignee: The Procter & Gamble Co.Inventors: John Christian Haught, Gregory Scot Miracle, Andre Christian Convents, George Douglas Hiler, II, David Johnathan Kitko
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Patent number: 7319113Abstract: A process is disclosed for recovering polyamide material from post-industrial and post-consumer products containing the polyamide material and insoluble materials. The process includes the steps of: (a) contacting the post-industrial and post-consumer products with a suitable solvent in a reactor; (b) dissolving and partially depolymerizing the polyamide material in the solvent to form a solution by operating the reactor at a predetermined temperature and pressure and for a time sufficient to decrease the average molecular weight of the depolymerized polyamide to less than 90% of the initial molecular weight; (c) separating the insoluble material from the solution; and (d) recovering the depolymerized polyamide from the separated solution. The process may also include the step of repolymerizing the depolymerized polyamide.Type: GrantFiled: March 24, 2004Date of Patent: January 15, 2008Assignee: E.I. du Pont de Nemours and CompanyInventor: Michael Stephen Mckinnon
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Patent number: 7319114Abstract: Hollow polymer particles are provided to have an average particle diameter of 15 ?m or more and 500 ?m or less and a 10%-compressive strength of 1.5 MPa or more, and the hollow polymer particle includes a hollow portion in the interior. In addition, a porous ceramic filter is provided by firing a shaped material composed of a mixture in which the above-described hollow polymer particles are mixed to disperse in a ceramic composition.Type: GrantFiled: March 12, 2002Date of Patent: January 15, 2008Assignees: Sekisui Chemical Co., Ltd., Tokuyama Sekisui Co., Ltd.Inventors: Takahiro Ohmura, Yasushi Nakata, Yasuhiro Kawaguchi, Takahiro Yoshida
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Patent number: 7319115Abstract: A hardener composition and pine bark tannin-containing resin composition are disclosed. The resin composition is formulated to neutral pH in order to reduce the extent of self-polymerisation and provide a satisfactory shelf life. The hardener composition may be mixed with a suitable resin, or the resin composition mixed with a suitable hardener to produce a cold set adhesive which is particularly useful for bonding wood.Type: GrantFiled: June 2, 2005Date of Patent: January 15, 2008Assignee: New Zealand Forest Research Institute LimitedInventors: Warren James Grigsby, Charles Duff McIntosh, Jeremy Martin Warnes, Ian Douglas Suckling, Charles Ross Anderson
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Patent number: 7319116Abstract: A flame resistant thermoplastic molding composition having improved mechanical properties is disclosed. The composition contains polycarbonate, a graft polymer and a phosphorus compounds of formula (I): and a mixture of fluorinated polyolefins with polyalkyl (meth)acrylates.Type: GrantFiled: July 31, 2003Date of Patent: January 15, 2008Assignee: Bayer MaterialScience AGInventors: Thomas Eckel, Andreas Seidel, Juan Gonzalez-Blanco, Dieter Wittmann
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Patent number: 7319117Abstract: The invention concerns a method for preparing a multiple emulsion comprising an invert emulsion consisting of an internal aqueous phase dispersed in an internal organic phase, dispersed in an external aqueous phase: the internal aqueous phase comprising optionally at least a hydrophilic active substance; the internal organic phase comprising optionally at least a hydrophobic active substance; the invert emulsion comprising at least an internal surfactant and/or at least an internal amphiphilic polymer; the external aqueous phase comprising optionally at least a hydrophilic active substance and at least an external surfactant and/or an external amphiphilic polymer.Type: GrantFiled: December 2, 2002Date of Patent: January 15, 2008Assignee: Rhodia ChimieInventors: Jean-Michel Mercier, Emmanuelle Vallier
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Patent number: 7319118Abstract: The present invention relates to the use of aqueous copolymer poly(vinyl ester) dispersions which comprise cellulose ethers in an amount up to a maximum of 0.45% by weight in food-coating compositions, and also food-coating compositions which comprise these aqueous copolymer poly(vinyl ester) dispersions, and their use in the coating of food, especially in the production of hard cheese.Type: GrantFiled: April 14, 2004Date of Patent: January 15, 2008Assignee: Celanese GmbHInventors: Bernd Papenfuhs, Holger Schimanke
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Patent number: 7319119Abstract: Oil-in-water emulsions which contain (i) 100 parts by weight of a polydimethylsiloxane (P) having aminoalkyl groups and having an amine number of at least 0.1 meq/g of polydimethylsiloxane (P), composed of units of the general formula I R1aR2bSiO(4?a?b/2),??(I) ?in which R2 are aminoalkyl radials of the formula II —R3—NR4R5,,??(II) (ii) protonating agent, (iii) water and (iv) not more than 5 parts by weight of emulsifier, are stable and provide for improved water repellency of porous and nonporous, absorptive and non-absorptive substrates treated therewith.Type: GrantFiled: December 8, 2004Date of Patent: January 15, 2008Assignee: Wacker Chemie AGInventors: Günter Mahr, Franz X. Wimmer, Willibald Burger, Ludwig Esterbauer
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Patent number: 7319120Abstract: Easily emulsified hydrophilic copolysiloxanes may be prepared by hydrosilylation employing an Si—H-functional organosiloxane with a compound containing both a hydrosilylatable group and an active hydrogen, and reacting the intermediate thus formed with a di- or polyisocyanate, wherein the reactants employed to produce the intermediate contain less than 2000 ppm water.Type: GrantFiled: December 18, 2003Date of Patent: January 15, 2008Assignee: Wacker Chemie AGInventors: Christian Herzig, Siegfried Dormeier
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Patent number: 7319121Abstract: The invention described relates to formed profiles comprising microcellular TPE foam compositions, and articles therefrom, wherein the TPE are thermoplastic vulcanizates. The foamed thermoplastic elastomer profile comprises a foamable thermoplastic elastomer composition having a) a cross-linkable hydrocarbon rubber in the presence of b) a thermoplastic polyolefin resin having a Tm greater than 120° C. wherein said composition further comprising: a) 25 to 30 wt % of a partially or fully vulcanized reaction product of said cross-linkable hydrocarbon rubber with a cross-linking agent, said reaction product being present as a dispersed phase; b) 7 to 12 wt % of said thermoplastic resin as a continuous phase; c) 8-22 wt % of an elastomeric thermoplastic modifier comprising 1) 3-7 wt. % copolymers of propylene with one or more of ethylene and C4-C10 alpha-olefins, said copolymers having a Tm greater than 20° C. and less than 120° C., and, 2) 5-15 wt.Type: GrantFiled: October 7, 2005Date of Patent: January 15, 2008Assignee: Advanced Elestomer Systems, Inc.Inventor: Sunny Jacob
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Patent number: 7319122Abstract: A blended polypropylene composition, fiber, and nonwoven articles made therefrom are provided. In one aspect, the blended polypropylene composition comprises a first polymer component having a molecular weight distribution of from 2.5 to 8, and a second polymer component having a molecular weight distribution of from 1.8 to 3. The first polymer component has a melt flow rate of greater than 30 g/10 min. and the second polymer component has a melt flow rate of less than 40 g/10 min., and the blended polypropylene composition has a melt flow rate of greater than 5 g/10 min.Type: GrantFiled: February 7, 2005Date of Patent: January 15, 2008Assignee: ExxonMobil Chemical Patents Inc.Inventors: Chia Yung Cheng, Galen Charles Richeson
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Patent number: 7319123Abstract: An initiator is presented for anionically polymerizing monomers, to provide a functional head group on the polymer. A polymer having a functional head group derived from a sulfur containing anionic initiator, and optionally as additional functional group resulting from the use of a functional terminating reagent, coupling agent or linking agent is also provided. A method is presented for anionically polymerizing monomers comprising the step of polymerizing the monomers with a sulfur containing anionic initiator to provide a functional head group on the polymer. An elastomeric compound, comprising a functional polymer and filler is also described. Also provided is a tire having decreased rolling resistance resulting from a tire component containing a vulcanizable elastomeric compound.Type: GrantFiled: December 2, 2006Date of Patent: January 15, 2008Assignee: Bridgestone CorporationInventors: Terrence E. Hogan, William Hergenrother, Yuan-Yong Yan, David Lawson
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Patent number: 7319124Abstract: The invention relates to novel organic sulphur-nitrogen compounds, their preparation, and use as vulcanizing agents for unsaturated rubbers and mixtures of these.Type: GrantFiled: March 30, 2005Date of Patent: January 15, 2008Assignee: LANXESS Deutschland GmbHInventors: Hermann-Josef Weidenhaupt, Hartmuth Buding, Josef Hahn, Andreas Mihalyi, Uwe Zettl
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Patent number: 7319125Abstract: This invention relates to a process to produce propylene polymers comprising contacting a metallocene catalyst compound and an activator in a reaction medium comprising propylene, from 0 to 30 volume % of one or more solvents and from 0 to 30 mole % of one or more comonomers, under temperature and pressure conditions below the melting point of the propylene polymer and where: a) the temperature is at or above the critical temperature for the reaction medium, and the pressure is at least 500 kPa above the critical pressure of the reaction medium; or b) the temperature is 1° C. or more above the critical temperature for the reaction medium, and the pressure is at or above the critical pressure of the reaction medium; or c) the temperature is 1° C. or more above the critical temperature for the reaction medium, and the pressure is at least 500 kPa above the critical pressure of the reaction medium.Type: GrantFiled: September 22, 2003Date of Patent: January 15, 2008Assignee: ExxonMobil Chemical Patents Inc.Inventors: Palanisamy Arjunan, Simon X. Zhang, Charles Cozewith
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Patent number: 7319126Abstract: Branched synthetic polyisoprenes are described having a macrostructure and a microstructure very similar to those of natural rubber. According to one aspect, these polyisoprenes have an apparent stress F/S0 greater than or equal to 0.4 MPa at a relative elongation ? of 150%, applied to a dumbbell-shaped test specimen consisting of the crosslinkable polyisoprene. According to another aspect, these polyisoprenes fulfill the relationship: Cotan ??0.3761. ?inh+0.15,:??(i) where cotan ? is the cotangent of the loss angle of a sample of said polyisoprene, measured at 130° C. by means of an instrument known by the trade name “RPA2000”, said sample being subjected to shear stress to 10% deformation and at a stress frequency of 0.035 Hz, and where ?inh is the inherent viscosity of said polyisoprene, measured in toluene at 25° C. and at a concentration of said polyisoprene in toluene of 0.1 g/dl.Type: GrantFiled: April 18, 2005Date of Patent: January 15, 2008Assignee: Michelin Recherche et Technique S.A.Inventors: Philppe Laubry, Fanny Barbotin, Philippe Johnson, Jean-Luc Auger
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Patent number: 7319127Abstract: Disclosed are nano-sized metals and metal salts stabilized by using semi-telechelic and telechelic polymers prepared through living anionic polymerization, and their synthetic methods, and a nanostructure wherein the nano-sized particles are self-assembled by mixing block copolymers and film-casting. The present invention provides a new method for preparing nano-sized particles capable of easily accomplishing nanostructure by merely mixing, especially with block copolymers, and having excellent stability.Type: GrantFiled: October 23, 2002Date of Patent: January 15, 2008Assignees: Korea Institute of Science and TechnologyInventors: Jungahn Kim, Kwang Ung Kim, Seung Sang Hwang, Dong-Youn Shin, Jang Seop Kim, Soon-Geun Hwang, Keon Hyeong Kim
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Patent number: 7319128Abstract: The present invention relates to a process for preparing organyloxysilyl-terminated polymers which have increased stability toward atmospheric moisture, by reacting hydroxy-terminated organic polymers with isocyanato-functional silanes in the presence of at least one catalyst selected from the group consisting of bismuth and zinc compounds, and to crosslinkable compositions comprising such polymers.Type: GrantFiled: October 21, 2004Date of Patent: January 15, 2008Assignee: Wacker Chemie AGInventors: Wolfgang Ziche, Wolfram Schindler
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Patent number: 7319129Abstract: The silsesquioxane derivative of the invention is represented by Formula (1), and it may be utilized as additives to ordinary organic polymers for improving the flame retardancy, heat resistance, weather resistance, light resistance, electric insulating property, surface property, hardness, mechanical strength and chemical resistance thereof. In Formula (1), R is hydrogen, alkyl, aryl or arylalkyl; at least one Y is a group represented by Formula (2) and the other Y is hydrogen; in Formula (2), R1 and R2 are a group independently defined similarly to R; and Z is preferably a functional group, or a group having a functional group.Type: GrantFiled: September 3, 2003Date of Patent: January 15, 2008Assignee: Chisso CorporationInventors: Kazuhiro Yoshida, Yoshitaka Morimoto, Kenichi Watanabe, Nobumasa Ootake
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Patent number: 7319130Abstract: The invention herein disclosed comprises the use of oxazolidines, nitroalcohols, nitroamines, aminonitroalcohols, imines, hexahydropyimidines, nitrones, hydroxylamines, nitro-olefins and nitroacetals to serve as hardeners and/or as catalysts for curing phenolic resins. The hardeners and catalysts described in the invention can be applied in any application where phenolic resins are used, including but not limited to adhesives, molding, coatings, pultrusion, prepregs, electronics, composites, fire resistant, and flame-retardant end uses.Type: GrantFiled: November 19, 2003Date of Patent: January 15, 2008Assignee: Angus Chemical CompanyInventor: Raymond J. Swedo
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Patent number: 7319131Abstract: The invention herein disclosed comprises the use of oxazolidines, nitroalcohols, nitrones, halonitroparaffins, oxazines, azaadamantanes, hexamethylenetetramine salts, nitroamines, imidazolidines, triazines, nitrooxazolidines, and imidazolidine-oxazolidine hybrids to serve as hardeners for curing phenolic resins. The hardeners and accelerators/catalysts described in the invention can be applied in any application where phenolic resins are used, including but not limited to fiber reinforced composite applications such as pultrusion, filament winding, bulk molding compound (BMC), sheet molding compounds (SMC), vacuum assisted resin transfer, prepregs, adhesives, foundry materials, abrasives, friction materials, insulation, laminates, coatings, electronics, fire resistant, and flame-retardant end uses.Type: GrantFiled: July 28, 2004Date of Patent: January 15, 2008Assignee: Angus Chemical CompanyInventors: Raymond J. Swedo, George David Green
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Patent number: 7319132Abstract: Polymeric compounds containing an oxetane functionality and a maleimide functionality have the structure in which polymer is a polymeric backbone, m and n are integers from 2 to 500, R1 is methyl or ethyl, R2 is a divalent hydrocarbon, and W and Z are independently an ether, carboxyl, ester, carbamate, urea or amide linking functionality.Type: GrantFiled: May 4, 2005Date of Patent: January 15, 2008Assignee: National Starch and Chemical Investment Holding CorporationInventor: Osama M. Musa
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Patent number: 7319133Abstract: The present contact lens treating systems and methods effectively remove extractable materials from contact lenses, for example, newly formed contact lenses, so that the lenses can be safely and conveniently worn, for example, for extended periods of time. Such treatment methods and the present extraction medium reprocessing methods allow lens treatment while reducing extraction medium losses, thereby reducing costs of these materials and the burden of such treatment on the environment. The present methods can also be useful for manufacturing a heat stabilized contact lens, for example, a water swelled contact lens including a Vitamin E component which is insoluble in the lens in a hydrated state.Type: GrantFiled: August 9, 2005Date of Patent: January 15, 2008Assignee: CooperVision, Inc.Inventors: Philip A. Brame, Sarah L. Almond
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Patent number: 7319134Abstract: An alteration in phosphorylation of serine 105, within the activation domain of NF-IL6/LAP, alters its transcriptional efficacy. Polypeptides, polynucleotides and methods of use for modified transcriptional activators allow regulation of gene expression.Type: GrantFiled: June 3, 2002Date of Patent: January 15, 2008Assignee: The Regents of the University of CaliforniaInventors: Michael Karin, Christian Trautwein
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Patent number: 7319135Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.Type: GrantFiled: April 23, 2002Date of Patent: January 15, 2008Assignee: Genentech, Inc.Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood
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Patent number: 7319136Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.Type: GrantFiled: May 14, 2002Date of Patent: January 15, 2008Assignee: Genentech, Inc.Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood
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Patent number: 7319137Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.Type: GrantFiled: June 26, 2002Date of Patent: January 15, 2008Assignee: Genentech, Inc.Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood
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Patent number: 7319138Abstract: This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, and C. elegans Dragon family members are also disclosed.Type: GrantFiled: April 17, 2003Date of Patent: January 15, 2008Assignee: The General Hospital CorporationInventors: Clifford J. Woolf, Tarek A. Samad
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Patent number: 7319139Abstract: Methods, compositions and kits comprising dimeric antibodies for the treatment of neoplastic, autoimmune or other disorders are provided. The dimeric antibodies of the instant invention may comprise two antibody molecules (H4L4) having the same antigen binding specificity (homodimers) or, alternatively, may comprise two different antibody molecules having binding specificity for two distinct antigens (heterodimers). In preferred embodiments the antibody molecules comprising the dimers are non-covalently associated.Type: GrantFiled: January 29, 2002Date of Patent: January 15, 2008Assignee: Biogen Idec, Inc.Inventors: Gary R Braslawsky, Nabil Hanna, Paul Chinn, Kandasamy Hariharan
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Patent number: 7319140Abstract: The purification and isolation of various genes which encode mammalian cell surface polypeptides. Nucleic acids, proteins, antibodies, and other reagents useful in modulating development of cells, e.g., lymphoid and myeloid, are provided, along with methods for their use.Type: GrantFiled: February 10, 2004Date of Patent: January 15, 2008Assignee: Schering CorporationInventors: Alexander B. H. Bakker, Joseph H. Phillips, Lewis L. Lanier
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Patent number: 7319141Abstract: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.Type: GrantFiled: October 19, 2004Date of Patent: January 15, 2008Assignees: Kirin Beer Kabushiki Kaisha, Nuvelo, Inc.Inventors: Y. Tom Tang, Ivan Labat, Radoje T. Drmanac, Nancy K. Mize, Mitsuo Nishikawa, Cheng-Chi Chao
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Patent number: 7319142Abstract: The invention provides isolated nucleotide sequences from Xenorhabdus nematophila species Xs86068, and, in particular, nucleotide sequences that encode insect inhibitory proteins, the insecticidal proteins, and compositions that comprise one or more of the insecticidal proteins for use in controlling insect infestation.Type: GrantFiled: August 31, 2005Date of Patent: January 15, 2008Assignee: Monsanto Technology LLCInventors: Barry S. Goldman, Karina Krasomil-Osterfeld, Thomas M. Malvar, John W. Pitkin, Steven C. Slater, Wei Wu, Jiamin Zeng
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Patent number: 7319143Abstract: The invention provides DNA molecules encoding a chimeric polypeptide comprising (a) a component of a MHC molecule capable of association on a cell surface with an endogenous MHC molecule component of the same class, and (b) an intracellular region of a signal transduction element capable of activating T cells. Component (a) may be a monomorphic component and is preferably beta 2-microglobulin, or a polymorphic class I or class II component. The signal transduction element (b) capable of activating T cells may be a component of T-cell receptor CD3, preferably the CD3 zeta (zeta) polypeptide, a B cell receptor polypeptide or an Fc receptor polypeptide. Immune cells such as a CTLs expressing said chimeric MHC molecules specifically eliminate or inactivate harmful T cells and are useful for treating graft rejection and autoimmune diseases.Type: GrantFiled: May 31, 2001Date of Patent: January 15, 2008Assignee: Gavish-Galilee Bio Application Ltd.Inventors: Gideon Gross, Alon Margalit
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Patent number: 7319144Abstract: The invention relates to a method of detecting HCV infection in a biological sample, the method comprising providing an immunoassay solid support, comprising an HCV anti-core antibody, an antigen comprising an HCV NS3/4a epitope, and an HCV multiple epitope fusion antigen, that can detect both HCV antigens and antibodies present in a sample. The invention also includes polynucleotides encoding multiple epitope fusion antigens for use in the assay, recombinant vectors and host cells comprising such polynucleotides, and methods of producing the multiple epitope fusion antigens.Type: GrantFiled: August 19, 2003Date of Patent: January 15, 2008Assignee: Novartis Vaccines and Diagnostics, Inc.Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
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Patent number: 7319145Abstract: The present invention provides methylenetetrahydrofolate reductase (MTHFR) inhibitors for use in selective inhibition of cancer cell growth in a mammal. These inhibitors can be a small molecule, an antisense oligonucleotide, a ribozyme, a triple helix forming oligonucleotide, an anti-MTHFR antibody or fragment thereof, an MTHFR mutant or a fragment of MTHFR. The present invention further provides nucleic acids encoding an inhibitor of MTHFR, and vectors comprising these nucleic acids. Also encompassed by the present invention are methods of using the MTHFR inhibitors for selective inhibition of cancer cell growth, and pharmaceutical compositions comprising the MTHFR inhibitors.Type: GrantFiled: December 3, 2001Date of Patent: January 15, 2008Inventors: Rima Rozen, Jaspreet Sekhon
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Patent number: 7319146Abstract: The present invention relates to a nonionic methyl ethyl hydroxyethyl cellulose ether having a flocculation temperature of 70-95° C., a DS-methyl of 0.1-0.8 and a DS-ethyl of 0.1-0.7. The cellulose ether has versatile properties and may be used as a thickening agent or a rheology modifier in an aqueous formulation, such as an aqueous latex-containing paint composition. A process for manufacturing the cellulose ether is also disclosed.Type: GrantFiled: January 16, 2004Date of Patent: January 15, 2008Assignee: Akzo Nobel N.V.Inventors: Peter Boström, Kenneth Sundberg
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Patent number: 7319147Abstract: New porphyrins and chlorins including bacteriochlorins, for photodynamic therapy.Type: GrantFiled: January 22, 2001Date of Patent: January 15, 2008Assignee: Bioscience Technology Investment Holdings LimitedInventors: Mehar Manku, David C Rice
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Patent number: 7319148Abstract: The invention concerns novel nucleotide analogues comprising a reactive hydrazide function used as initial synthons for preparing compounds (formula I) capable of inducing mutations or capable of inhibiting a DNA polymerase or a kinase. The invention also concerns nucleic acids comprising said nucleotide and nucleoside analogues.Type: GrantFiled: June 13, 2001Date of Patent: January 15, 2008Assignee: Institut PasteurInventors: Philippe Marliere, Sylvie Pochet
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Patent number: 7319149Abstract: Chelants and macrocyclic metal complexes thereof, methods of preparing the chelants and macrocyclic metal complexes, and radiopharmaceutical compositions comprising the macrocyclic metal complexes are disclosed. Methods of using the macrocyclic metal complexes as radiopharmaceuticals for the diagnosis of cardiovascular disorders, infectious diseases and cancer are also disclosed. Chelants as bifunctional chelators (BFCs) for the radiolabeling of target-specific biomolecules, such as proteins, peptides, peptidomimetics, non-peptide receptor ligands, enzyme inhibitors, and enzyme substrates are disclosed. Methods of using macrocyclic metal complexes containing the chelant-biomolecule conjugates as target-specific diagnostic radiopharmaceuticals that selectively localize at sites of disease and allow an image to be obtained of the loci using gamma scintigraphy are disclosed.Type: GrantFiled: June 9, 2004Date of Patent: January 15, 2008Assignee: Bristol-Myers Squibb Pharma CompanyInventor: Shuang Liu
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Patent number: 7319150Abstract: The invention concerns a method for synthesizing styryl isoxazole, styryl pyrazole and styryl isothazole derivatives in a synthesis step followed by a recrystallization in a basic alcohol medium.Type: GrantFiled: July 24, 2003Date of Patent: January 15, 2008Assignees: Laboratoires Mayoly Spindler, Centre National De La Recherche Scientifique, Universite De Montpellier 2Inventors: Damien Gloux, Marc Criton, Jean-Louis Montero
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Patent number: 7319151Abstract: Provided are new two-photon absorbing chromophores of the formula: wherein R is an alkyl group having 1 to 20 carbon atoms and Q is OH, OMe, propargyloxy-(O—CH2—C?CH), methylpropargyloxy-(O—CH2—C?C—CH3), allyloxy-(O—CH2—C?CH2),1-methyl-allyloxy(O—CH2—CH?CHCH3) and 3-methyl-allyloxy (O—CH(CH3)—CH?CH2).Type: GrantFiled: February 13, 2006Date of Patent: January 15, 2008Assignee: United States of America as represented by the Secretary of the Air ForceInventors: Loon-Seng Tan, Ramamurthi Kannan
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Patent number: 7319152Abstract: Compounds of formula I or II are provided, wherein R1-R8 are defined herein, and pharmaceutical compositions and kits containing these compounds.Type: GrantFiled: September 18, 2006Date of Patent: January 15, 2008Assignee: WyethInventors: Puwen Zhang, Jeffrey Curtis Kern, Eugene Anthony Terefenko, Eugene John Trybulski
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Patent number: 7319153Abstract: 6,13-bis(thienyl)pentacene compounds are described that can be used as a semiconductor material. Semiconductor devices that contain the 6,13-bis(thienyl)pentacene compounds and methods of making such semiconductor devices are also described.Type: GrantFiled: July 29, 2005Date of Patent: January 15, 2008Assignee: 3M Innovative Properties CompanyInventors: Dennis E. Vogel, Kim M. Vogel
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Patent number: 7319154Abstract: This invention relates to processes for the production of 3-oxo-pregnane-21,17-carbolactones of formula II as well as 3-oxo-pregn-4-ene-21,17-carbolactones of formula III by the metal-free oxidation of 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanes of formula I In addition, the invention relates to the dichloromethane hemisolvate of 6B,7B;15?,16?-diethylene-3-oxo-17?-pregnan-5?-ol-21,17-carbolactone (IV) as such.Type: GrantFiled: July 21, 2005Date of Patent: January 15, 2008Assignee: Bayer Schering Pharma AGInventors: Carsten Seilz, Hartmut Seba
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Patent number: 7319155Abstract: Novel 7,7-disubstituted (5H,9H)-6,8-dioxabenzocycloheptene compounds having the structural formula (I): are useful intermediates in the synthesis of non-steroidal derivatives of vitamin D.Type: GrantFiled: November 14, 2006Date of Patent: January 15, 2008Assignee: Galderma Research & DevelopmentInventors: Eric Terranova, Jean-Claude Pascal
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Patent number: 7319156Abstract: There is disclosed a process for producing an olefin oxide, which is characterized by reacting an olefin with oxygen in the presence of a silver catalyst and 0.2 mole or more of water per mol of the olefin.Type: GrantFiled: March 19, 2004Date of Patent: January 15, 2008Assignee: Sumitomo Chemical Company, LimitedInventors: Makoto Yako, Michio Yamamoto
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Patent number: 7319157Abstract: The present invention describes compounds produced from a creatine molecule and a fatty acid molecule. The compounds being in the form of creatine-fatty compounds bound by an amide linkage, or mixtures thereof produced by reacting creatine or derivatives thereof with an appropriate fatty acid in the presence of dichloromethane and a pyridine catalyst, previously reacted with a thionyl halide. The administration of such molecules provides supplemental creatine with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.Type: GrantFiled: February 20, 2007Date of Patent: January 15, 2008Assignee: Multi Formulations Ltd.Inventors: Shan Chaudhuri, Joseph MacDougall, Jason Peters, James Ramsbottom
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Patent number: 7319158Abstract: A process for producing a high-purity hafnium amide includes the steps of (a) adding a compound which contains a carbonyl group or sulfonyl group and is represented by the formula of A(OyXOnRf)m (e.g., CF3SO3H, Hf(CF3SO3)4, (CF3SO2)2O, CF3CO2H, CH3SO3H, C6H5SO3H, and (CH3SO2)2O), to a crude hafnium amide which is represented by the formula of Hf[N(R1)(R2)]4, where each of R1 and R2 independently represents a methyl group or ethyl group, and which contains a zirconium component as an impurity; and (b) subjecting a product of the step (a) to a distillation under reduced pressure, thereby removing the zirconium component from the crude hafnium amide.Type: GrantFiled: February 13, 2007Date of Patent: January 15, 2008Assignee: Central Glass Company, LimitedInventors: Atsushi Ryokawa, Shuhei Yamada