Abstract: Nasal pharmaceutical formulations comprising a drug substance having a specific particle size distribution profile are disclosed herein. Such profile provides increased bioavailability, increased efficacy or prolonged therapeutic effect of the drug substance when administered intranasally. The formulations of the present invention may comprise one or more corticosteroids having a specific particle size distribution profile. In a preferred embodiment, the corticosteroid is beclomethasone or a pharmaceutically acceptable derivative thereof for the treatment of one or more symptoms of rhinitis. Preferably, the drug substance is beclomethasone dipropionate. The formulations herein may be provided as an aqueous suspension suitable for inhalation via the intranasal route.

Abstract: Solid oral dosage forms that include melt granules of a moisture-sensitive therapeutic compound and a hydrophobic melt component. The melt granules better protect the therapeutic compound from hydrolytic degradation. Such solid oral dosage forms also possess immediate-release characteristics rather than that associated with extended-release or controlled-release drug products.

Abstract: The present invention relates to pharmaceutical compositions comprising solid particles of an active ingredient that have a particle size of from about 0.1 micron to about 100 microns.

Abstract: Taught herein is a drug-delivery system that includes encapsulating a therapeutic drug in a nanoparticle vesicle that is then embedded into a hydrogel network. The system allows for enhanced, two-fold control over the release rate of the drug. This technology will be particularly advantageous in treating malignant cancer cells such as those found in the brain. The invention will allow for decreased side effects and increased survival time in patients. This invention opens the door to other technological applications that require controlled release of chemical substances.

Abstract: A multiparticulate, pharmaceutical dosage form containing at least one antibiotic which is sparingly wettable with aqueous media or sparingly soluble in aqueous media and a combination of carrageenan and tricalcium phosphate and optionally sucrose ester. Also, an administration system having this dosage form arranged in a drinking straw with at least one barrier device for single administration, optionally together with a conveying liquid.

Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.

Abstract: The present invention presents a metallic nanoparticle-ligand-photosensitiser conjugate, a method of making such conjugate, and a method of using such mixture for killing or preventing the growth of microbes.

Abstract: The invention encompasses stable multiparticulate pharmaceutical compositions of tolterodine having at least one pharmaceutically acceptable excipient and at least two populations of multiparticulates each population having tolterodine or a salt thereof and the ratio of the populations is from 90:10 to 10:90 by weight, wherein after storage for 1 month at 40° C. and 75% relative humidity the difference between the dissolution profile at 4 hours is no more than about 5% when compared to the dissolution profile at the time of manufacture.

Abstract: Active agent compositions comprising active agent particles having an effective average particle size of less than 2000 nm, wherein the compositions comprise a particle sequestrant are disclosed. Compositions having an effective average particle size of less than 2000 nm, wherein the compositions comprise no added surfactants, phospholipids, or combinations thereof, are also disclosed. In some embodiments, the active agent is fenofibrate. In other embodiments, the fenofibrate compositions are in a treatment form that that is bioequivalent to TriCor® 145 mg or 48 mg.

Abstract: The present invention is in the medical and consumer arenas. The invention presents the use of a salivary amylase assay to diagnose, quantify, and monitor the hydration status, the onset and progress of shock in an animal that produces salivary amylase, such as a human. The assay tests the saliva sample from the animal. Test kits and assays for such use are also presented.

Abstract: Metal-containing materials, as well as their preparation, formulations, and use are disclosed.

Abstract: The invention discloses a trace element solution, which comprises at least one metal selected from the group comprising selenium, copper, zinc, manganese and chromium and which comprises a concentration of the metal(s) of at least 60 mg/ml. The solution further comprises at least one compound selected from the group comprising iodine, potassium iodide, sodium iodide, iron, iron chloride, zinc oxide, manganese sulphate, sodium selenite, copper carbonate, sodium carbonate, anhydrous disodium EDTA and sodium hydroxide. The trace element solution is prepared by a method consisting essentially of the steps of preparing a MnCO3 mixture in a container; adding an EDTA/NaOH mixture to the container and subsequently adding at least one metal compound; and adding Na2SeO3 to the container to obtain the trace element solution. The method also comprises the step of adding CrCl3.6H2O to the trace element solution.

Abstract: The present invention relates to compositions that may be swallowable, chewable or dissolvable, comprising various vitamins and minerals, and in a specific embodiment comprising vitamin A, beta carotene, B-complex vitamins, vitamin C, vitamin D3, vitamin E, iron, magnesium and zinc, and methods for using these compositions for nutritional supplementation in subjects undergoing physiologically stressful events, such as, for example and without limitation, pregnancy, lactation or any disease state.

Abstract: An equine gastric ulcer therapy composition comprises a pre-packaged, dry feed supplement comprising effective amounts of chamomile tea and an effective amount of slippery elm with effective amounts of apples and a natural sweetener. An alternative composition comprises a pour-able aqueous solution of an effective amount of chamomile tea and an effective amount of slippery elm, wherein the solution has a viscosity of at least 100 cP at about 20° C., or about 80 cSt at about 25° C. A method of treating equine ulcers comprises a regime of Omeprazole for an initial treatment period followed by treatment with the described nutraceutical equine gastric ulcer therapy composition.

Abstract: The present invention relates to intramammary formulations, as well as methods of treating an intra-mammary infection in a lactating non-human animal and preventing re-infection by internal administration of the formulations. The formulations include a combination of penicillin, aloe vera and Centella asiatica extract.

Abstract: The invention relates to a Ginkgo biloba extract and to a method for producing the same. The invention especially relates to a Ginkgo extract having an increased content in desired, pharmaceutically effective active ingredients and to a method which uses water as the extractant.

Abstract: The invention relates to a composition comprising a lupin total extract consisting of a lupin sugar extract, comprising at least 50% galactooligosaccharides by weight, in relation to the weight of dry matter, and a lupin peptide extract. The composition can also contain a chromane derivative or a chromene derivative. The invention also relates to a pharmaceutical and/or cosmetic composition comprising said lupin total extract, used advantageously as an anti-inflammatory agent, which repairs the cutaneous barrier and heals, used particularly in the prevention and/or treatment of erythemas.

Abstract: A cosmetic preparation comprises an effective amount of Phyllanthus Embilca fruit extract and at least one oligopeptide such as Oligopeptide-4 and Oligopepticje-5 (pro-Elastin oligopeptide) The cosmetic preparation may further comprise Licorice extract, and Alpha-arbutin. It has surprisingly been found that this cosmetic preparation displays a beneficial synergistic effect for the combined treatment of fine line and wrinkles and/or skin brightening.

Abstract: Provided herein are novel onco-fetal carbohydrate motifs present in adenocarcinoma cells. This novel carbohydrate motif is preferentially recognized by tomato fruit lectin-conotoxin. Also provided are methods for inhibiting proliferation and growth of cancer cells and for treating pathophysiological conditions, e.g., cancer, chronic pain, inflammation and/or a microbial infection, by contacting such cells with or administering tomato fruit lectin-conotoxin or similar natural or bioengineered molecules. In addition provided herein are genetically modified plants and seed, fruit, progeny, and hybrids therefrom and a genetically modified foodstuffs overexpressing a lectin-conotoxin. Further provided are DNA and expression vectors expressing lectin-conotoxin described herein.

Abstract: Nanoparticulate compositions comprising at least one poorly soluble angiogenesis inhibitor and at least one surface stabilizer are described. The nanoparticulate compositions have an average particle size of less than about 2000 nm. The invention also describes methods of making and using such compositions.

Abstract: Medical device balloons are formed from a tubular parison by a process or apparatus which establishes a controlled location (initiation zone) on the parison where radial expansion is initiated. Initiation within the initiation zone is achieved by heating the parison in that location to a higher temperature than the remainder of the parison for at least a portion of the blowing time. A variety of apparatus configurations are provided, some of which allow for the size and location of the initiation zone to be readily reconfigured. Balloons can also be modified, post-blowing, using heating apparatus and methods described.

Abstract: A stacked type tooling is formed by stacking a plurality of slices. Each slice has a plurality of patterned openings. When these slices are stacked together, The patterned openings form at least a cavity. Unnecessary volume of the tooling can be avoided to shrink the size of the tooling and let the tooling be lightweight. Moreover, the manufacturing cost and time of the tooling can be substantially reduced.

Abstract: An actuator is disclosed, in particular for a locking unit of an injection compression machine, comprising a hydraulic force translator with two piston units moving relative to each other with different effective areas. The foregoing enclose a pressure chamber together with a cylinder or spacer of the force translator. The smaller piston unit is electrically driven, wherein the axial displacement of the smaller piston unit may be transmitted to the cylinder. The cylinder can be fixed relative to a chassis of the injection compression machine by means of a hydraulic clamping device. According to the invention, the pressure necessary for clamping is delivered by a high-pressure reservoir which may be charged during the displacement of the smaller piston unit.

Abstract: A die and mold for manufacturing a mold product is provided. The die and mold includes a body having a cavity that has a shape corresponding to the mold product. The body includes an upper body plate, and a lower body plate facing the upper body plate and combined with the upper body plate. The die and mold also includes a gate. The gate includes an upper gate plate, a plurality of recesses formed on a lower surface of the upper gate plate, and a lower gate plate facing the upper gate plate. A plurality of protrusions is formed on an upper surface of the lower gate plate in a location corresponding to a location in which the plurality of recesses is formed. The gate also includes a resin injection portion through which a resin is injected into the cavity.

Abstract: A collar for reducing or eliminating leakage between components, which move with respect to each other in the field of injection molding. The collar has an outer portion for receiving an inner portion. The outer portion has a tapered or partial spherical surface on its inside diameter, and the inner portion has a tapered or partial spherical surface on its outside diameter. In the preferred embodiment, the inner portion of the collar is operatively assembled into a cavity of the outer portion of the collar, such that the tapered surface of the inner portion is slidably mounted to the tapered surface of the outer portion. The collar is operatively mounted around the outside diameter or circumference of a cylindrical device and between two components that move with respect to each other. Springs, discs, cylinders or other device are used to create an axial force AF between the components, which move with respect to each other.

Abstract: The present invention relates to a composition and a method of preparing cheese products with a suitable moisture level. The cheese products that have been formed using the composition are characterised with an improve at least one of aroma, flavour, mildness, consistency, texture, syneresis, body, mouth feel, firmness, viscosity, gel fracture, wheying off, structure and/or organoleptic properties, nutrition and/or health benefits. In particular, the present invention provides a composition comprising a starter acidification micro-organism and an EPS fermentation culture comprising a viable micro-organism an enzyme produced by said micro-organism and an exopolysaccharide (EPS) produced by the activity of said enzyme.

Abstract: The present invention relates to a chewing gum base formulation comprising a biocompatible particulate polymer having an average particle size of from about 200 ?m to about 2000 ?m wherein the polymer fibrillates when subjected to a shear stress such as that encountered during chewing.

Abstract: A jumping window based fast pattern matching method using TCAM includes TCAM entries containing all possible sub-patterns independent of position. Due to these sub-patterns, the method can search for all patterns appearing within the window at once. If a match is not found, the method jumps to the next window (shift size of M bytes), opposed to the sliding window method that shifts to the next byte (shift size of 1 byte). This incurs a pattern match that is M times faster, despite requiring a larger TCAM size to be able to represent all possible redundant sub-patterns in the TCAM; here, M is the size of a jumping window. In addition, the present invention employs a two-phase pattern matching sequence for a large number of long patterns such as virus and worm signatures. In the first phase, the fixed prefix will be searched with TCAM; then, only the CRC value for the remaining pattern is examined to confirm the existence of the entire pattern.

Abstract: The present invention pertains to novel aspartic endoproteinases from Th. cacao which are involved in the production of cocoa flavor and DNA sequences coding for them. These enzymes are advantageously used in the manufacture of cocoa flavor.

Abstract: A method which comprises using a treatment apparatus comprising (1) a treatment tank, (2) a vibrating stirrer disposed inside the treatment tank, (3) a photocatalyst layer or a layer comprising a photocatalyst and a bactericidal metal, disposed on any surface inside the treatment tank, and (4) a light irradiator; placing water or a water-containing fluid to be treated in the treatment tank; carrying out the steps of (i) transmitting vibration between 10 and 200 Hz to a vibration vane by a vibration generator to causing the vibration vane to vibrate at an amplitude of 0.01 to 15 mm, and (ii) irradiating the photocatalyst or the layer comprising a photocatalyst and a bactericidal metal with light.

Abstract: A dietary supplement and method for increasing energy and mental alertness of an individual, e.g. a human or an animal is provided comprising at least Caffeine Anhydrous, Taurine, an a plant extract providing antioxidant activity. Additionally, a method for increasing energy and metal alertness in an individual, e.g. a human or an animal is also provided.

Abstract: Disclosed is process for formation of a baked fruit filled bar comprising omega-3 fatty acids and a carrier oil wherein the bar is stable for over 12 weeks at 85° F. 50% relative humidity with no development of a fishy taste or aroma over the storage period. The preferred carrier oils have oxidative stability indexes of at least 30 hours and solid fat contents at 21° C. of at least 40.

Abstract: The disclosure describes new forms of chip-type and other fried or baked snack-type and/or convenience food items, including sweet goods such as cookies, doughnuts, etc., which are externally coated with or which directly incorporate into their dough matrix certain starch-based compositions. Methods of using the compositions to make the food products, and the finished food products themselves are described. As external coatings, the compositions significantly increase the crispness and tensile strength of the food item after it is cooked with the coating in place, and so change the organoleptic qualities as to provide a new form of the underlying food product. On sweet goods, the coating also provides a surface barrier that stabilizes sugar icing on the outside of the product, preventing it from becoming tacky, moist, or wet, while simultaneously reducing moisture loss from the dough, adding crispness at the surface and greatly retarding staling.

Abstract: Disclosed is a cold formed bar comprising an omega-3 fatty acid and a carrier oil having an oxidative stability of at least 30 hours and a solid fat content at 21° C. of at least 40. The bar is preferably enrobed in a compound coating and has a water activity of from 0.45 to 0.57. The combination of carrier oil, low temperature processing, low water activity and enrobing stabilizes the omega-3 fatty acids in the bar so that the bar is stable at 85° F. 50% relative humidity for at least 3 months without developing fishy aromas, fishy tastes, or other off tastes over the storage period.

Abstract: Disclosed is a process for stabilizing an omega-3 fatty acid containing powder onto a food product. The food product is coated with a coating oil and then the powder containing at least one powdered omega-3 fatty acid comprising at least one of docosahexaenoic fatty acid, eicosapentaenoic fatty acid, or a mixture thereof is applied onto the food product. The coated food product is then packaged and is stable for at least 12 weeks of storage at 70° F. 50% relative humidity as defined by the absence of development of a fishy aroma or taste. The process is widely applicable to a variety of food products including ready to eat cereals, quick cooking oatmeal, cereal bars, granola bars, potato chips, nacho chips, corn chips, cookies, crackers, pretzels, baked cheese curls, fried cheese curls and other food products.

Abstract: The invention relates to a small stick of the type that is used in the food service industry, but which, instead of being made from wood, plastic or metal, is made from edible materials suited to the use thereof, both in terms of hardness d shape as well as in terms of flavour such as to be compatible with the food being served. The basic form of the stick comprises a body (1), a pointed end (2) for piercing the food and an opposing flat end (3) that enables the stick to be gripped comfortably.

Abstract: A pressure resistant thermoplastic container. The container may include a sidewall and a number of indentations formed in the sidewall. One or more of the indentations may include one or more reinforcements formed therein.

Abstract: There is provided a commercially packaged mammal pet food product that includes a manufactured, shelf-life stable food substrate and a combination of functional additives. The functional additives include at least one non-palatable plant-based remedy and/or dietary fiber source that are present to strengthen and/or maintain a specified health indicator of a mammal pet animal. The food product is portioned and packaged with the functional additives being present in predetermined concentrations and amounts sufficient to be effective in achieving said indications on regular feeding of the pet animal with said food product. The food substrate is present in a proportion sufficient to mask the flavor and/or odor of the non-palatable additive and is made-up of a unique combination of materials that are able to be processed at lower temperatures to preserve the natural botanical functional additive's activity.

Abstract: A dispensing apparatus for hot beverages is provided with means (4,5) to filter hot pressurised water through ground edible ingredients such as coffee, tea or herbal remedies in a chamber, means (17,18,20) of monitoring real-time data concerning brewing parameters; a controlling unit (16) comprising means of storing data, means of comparing the real-time data to a set of stored data and/or threshold parameters, stored in the controller's memory associated with the brewing system, to determine whether a correction to the parameters should be made, and means (8,9,24) of altering at least one of the relevant brewing parameters, when required to bring said real time parameter in line with said recorded parameter to obtain consistent high quality of the dispensed beverage.

Abstract: A method, system and apparatus for maintaining a controlled atmosphere having a high carbon dioxide content in a sealed container is provided. In the method, the container is substantially impermeable to oxygen and carbon dioxide and contains respiring horticultural produce. The method comprises monitoring the oxygen or carbon dioxide content in the atmosphere and, when the oxygen content approaches a level at which the produce becomes anaerobic, delivering a gas containing oxygen into the container such that the oxygen content in the atmosphere is again sufficient to allow the produce to respire. The high carbon dioxide content in the atmosphere causes the storage life of the produce to be extended.

Abstract: A method and kit is usable to marinate and tenderize food in a reduced-pressure environment. The kit includes a foraminous shell in which the food is placed, and a sealable bag in which the food, shell and marinade are placed. A vacuum pump and bag sealer are then used to create and maintain a reduced-pressure environment, creating voids within the food. While the reduced-pressure environment is maintained within the bag during a soak period, the user may vibrate, rotate, refrigerate, shake, or tumble the bag with the food and shell therein. During soaking and upon pressure equalization when the bag is opened, the marinade is drawn into the voids, thereby reducing the amount of time needed to marinate and tenderize foods. After removing the food from the shell and bag, the food may be stored, cooked or served. The foraminous shell is durable, washable, and re-usable.

Abstract: The present disclosure provides an apparatus and method for the continuous production of center-filled confectionery products. The apparatus may include an extruder for forming a continuous extrudate having a plurality of adjoined center-filled confectionery ropes. The apparatus may also include a forming device for forming individual confectionery pieces, and sealed center-filled confectionery pieces in particular. The apparatus provides improved coordination and control of extrudate formation and extrudate feed into the forming device. The apparatus and method of the present disclosure increases product output and reduces the amount of unacceptable product.

Abstract: The present invention provides a process of manufacturing a filled confectionery product with extended shelf-life comprising at least one high water activity component and at least one low water activity component, which process comprises pasteurizing the confectionery product under pressure after hermetically sealing said product in its final primary package providing a hermetic seal for the product. Moreover, there are also provided filled confectionery products obtainable by this process.

Abstract: A shelf-stable acidified food product having an edible food and two or more acidulants with sufficient acid to achieve a pH below 4.6. The two or more acidulants are admixed with the edible food in an amount effective to adjust the pH of the food product to the range of 3.8 to 4.5. In some embodiments, the two or more acidulants comprises gluconic acid and sodium acid sulfate.

Abstract: Disclosed is a method for quenching the aldyhyde products of lipid autoxidation. The method includes providing a source of amino acids that are capable of binding the aldyhyde products to thereby quench them. The method finds particular use in the food industry wherein the quenching of autoxidation products is useful in maintaining food appeal to consumers and food product shelf life, especially when incorporating long chain polyunsaturated fatty acids into the food product.

Abstract: “PROCESS OF PRODUCTION AND PACKAGING OF PASTAS IN GENERAL WITH SAUCE NOT INCORPORATED TO THE PASTA”, especially of a production process in that the pasta (1) and the sauce (2), basic components of plates as lasagna, cannelloni, among others, is prepared in stratified sheets through freezing, of a way that the sauce (2), for being in solid state, it is not mixed with the pasta (1), equally frozen, not interfering in the taste of the pasta and vice-versa, being said stratified sheets conditioned to vacuous in wraps (3) made of impermeable, colorless plastic, resistant to the water in ebullition point. Although the food can be warm in microwave oven or conventional oven, since under water in ebullition point, it is preferable the heating in water in ebullition point obtained in the burner of the stove or similar.

Abstract: A system for making a beverage, the system comprising a pad (7) and a holder (6) in which the pad (7) is placed in use, the pad being provided with a chamber in which a product (24) required for making the beverage is situated, the system defining, at least partly, a fluid path, while the fluid path extends, in use, at least through the product (24) in the pad (7), while in use a fluid is introduced into the fluid path under super-atmospheric pressure, wherein the system is designed for assuming two conditions, i.e. a froth condition in which a beverage with a froth layer is produced, and a froth-free condition in which a beverage substantially without froth layer is produced. Also is described a restriction element (15a, 16, 18, 19, 20) and a pad (7) and the use of such a system as a method for making beverage.

Abstract: The invention relates to a method for extracting ?-glucan from cereals. The extraction is carried out using wetted cereals by adjusting the pH thereof to a value below 5.2 with an acid, and further, by treating the cereal in an enclosed space under pressure less than about 5 bar, at a temperature of 100-130° C. After the treatment, the liquid phase is separated from the solid material, followed by recovery of ?-glucan from this separated aqueous phase.

Abstract: A method of preparing a single serving of a nutritional composition comprising introducing water into a disposable capsule (30) containing a unit dose of the composition in concentrated form so as to reconstitute the concentrated composition and operate opening means contained within the capsule to permit draining of the resulting liquid directly from the capsule (30) into a receiving vessel. The method allows individual servings of nutritional compositions such as infant formulas to be prepared with substantially reduced or even eliminated risk of cross contamination from previously prepared servings.

Abstract: The water heating flow detection system for a beverage maker includes a heater control logic circuit that controls heating in response to temperature and flow conditions in the beverage maker. A heater control logic circuit receives a temperature detection signal and a flow detection signal, and generates a water heater control signal for controlling operation of one or more water heaters. A flow detection device may be connected to the hot water outlet conduit or the cold water inlet conduit, and may include a magnetic flow detection device. A faucet lever position detection device may also be used to indicate flow through a faucet outlet valve.