Patents Issued in April 29, 2008
  • Patent number: 7365178
    Abstract: The present invention provides tagged acyl phosphate probes (“TAPPs”), and methods of their preparation and use. The subject methods and compositions can provide enhanced simplicity and accuracy in identifying changes in the presence, amount, or activity of target proteins in a complex protein mixture, preferably nucleotide binding proteins using nucleotide binding protein-directed TAPPs. The profiling methods described herein can have a number of steps leading to the identification of target nucleotide binding protein(s) in a complex protein mixture.
    Type: Grant
    Filed: April 1, 2004
    Date of Patent: April 29, 2008
    Assignee: Activx Biosciences, Inc.
    Inventors: David Alan Campbell, Marek Liyanage, Anna Katrin Szardenings, Min Wu
  • Patent number: 7365179
    Abstract: The invention provides a system and reagents for carrying out multiplexed analytical measurements using the hybridization of oligonucleotide tags to addressable solid phase supports to obtain simultaneous readouts from hundreds to tens of thousands of reactions. In one aspect of the invention, analyte interaction moieties, such as oligonucleotide probes, are produced that are each labeled with a unique synthesis tag constructed from a set of two-nucleotide “words.” During or after an assay, the synthesis tags are converted to hybridization tags that are used in the readout step. Hybridization tags are constructed to maximize discrimination in the readout. Hybridization tags of the invention are preferably constructed from oligonucleotide “words” selected from a minimally cross-hybridizing set using combinatorial synthesis techniques.
    Type: Grant
    Filed: September 2, 2004
    Date of Patent: April 29, 2008
    Assignee: Compass Genetics, LLC
    Inventor: Sydney Brenner
  • Patent number: 7365180
    Abstract: The present invention relates to cell wall degradative systems, in particular to systems containing enzymes that bind to and/or depolymerize cellulose. These systems have a number of applications.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: April 29, 2008
    Assignee: University of Maryland
    Inventors: Larry Edmund Taylor, Ronald M. Weiner, Steven Wayne Hutcheson, Nathan A. Ekborg, Michael Howard
  • Patent number: 7365181
    Abstract: Markers for detecting and staging chondrogenesis in cells are provided. In one aspect the markers are isolated polynucleotides, referred to hereinafter as CZF-1 and CZF-2, and fragments thereof. In one embodiment, the CZF-1 polynucleotide comprises the open reading frame sequence set forth in SEQ ID NO.1. In one embodiment, the CZF-2 polynucleotide comprises the open reading frame sequence set forth in SEQ ID NO. 3. In another aspect the markers are antibodies, which are immunospecific for proteins encoded by CZF-1 or CZF-2. Methods which employ the present markers to identify cells that have begun to differentiate into chondrocytes are provided. The present invention also relates to the CZ-1 protein and the CZ-2 protein and to polynucleotides or oligonucleotides whose sequences are complementary to the coding sequences of CZF-1 or CZF-2, or regions thereof.
    Type: Grant
    Filed: July 21, 2003
    Date of Patent: April 29, 2008
    Assignee: Case Western Reserve University
    Inventors: Thomas M. Hering, Brian Johnstone
  • Patent number: 7365182
    Abstract: The present invention relates to plant genes involved in regulating flowering, and especially to genes involved in the induction of flowering in response to cold, or vernalization. In particular, the present invention provides the identification, cloning, and characterization of genes involved in vernalization, and specifically of VIP genes, as well as to the proteins encoded by these genes, and to methods of using the VIP genes and proteins. Mutants of VIP genes, where the mutation is a knock-out mutation, confer a vernalization independence, or constitutively vernalized, phenotype in a plant which in the non-mutant form requires vernalization to flower.
    Type: Grant
    Filed: May 1, 2003
    Date of Patent: April 29, 2008
    Assignee: Michigan State University
    Inventors: Steven R. Van Nocker, Hua Zhang
  • Patent number: 7365183
    Abstract: The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in cells, either as a promoter or as a protein coding sequence or as an UTR or as a 3? termination sequence, and are also useful in controlling the behavior of a gene in the chromosome, in controlling the expression of a gene or as tools for genetic mapping, recognizing or isolating identical or related DNA fragments, or identification of a particular individual organism, or for clustering of a group of organisms with a common trait.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: April 29, 2008
    Assignee: Ceres, Inc.
    Inventors: Nickolai Alexandrov, Vyacheslav Brover, Kenneth Feldmann
  • Patent number: 7365184
    Abstract: The present invention pertains to the discovery that B. anthracis possesses a luxS gene that encodes a functional LuxS polypeptide, and that B. anthracis synthesizes a functional AI-2 quorum-sensing molecule. The invention provides mutant B. anthracis bacteria lacking the function of the luxS gene, which do not produce a functional AI-2 molecule and have growth defects compared to wild-type B. anthracis. The invention also concerns methods for inhibiting the growth of B. anthracis, or for preventing or treating B. anthracis infection, by inhibiting the activity of the B. anthracis LuxS polypeptide, or by exposure of the B. anthracis to furanone. In particular, the invention concerns the use of furanone, a compound that inhibits AI-2-mediated quorum-sensing, to inhibit the growth of B. anthracis, to inhibit B. anthracis toxin production, particularly that of protective antigen, and to prevent or treat B. anthracis infection. The invention also provides methods to prevent B.
    Type: Grant
    Filed: April 12, 2004
    Date of Patent: April 29, 2008
    Assignee: New York University
    Inventors: Marcus B. Jones, Martin J. Blaser, Thomas Wood, Dacheng Ren
  • Patent number: 7365185
    Abstract: The present invention discloses rice genomic promoter sequences. The promoters are particularly suited for use in rice and other cereal crops. Methods of modifying, producing, and using the promoters are also disclosed. The invention further discloses compositions, transformed host cells, transgenic plants, and seeds containing the rice genomic promoter sequences, and methods for preparing and using the same.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: April 29, 2008
    Assignee: Monsanto Technology LLC
    Inventors: Andrey A. Boukharov, Yongwei Cao, Stanton B. Dotson, Jeffrey M. Koshi, David K. Kovalic, Jingdong Liu, James D. McIninch, Wei Wu
  • Patent number: 7365186
    Abstract: Plant polynucleotide promoter sequences are provided, together with DNA constructs comprising the inventive polynucleotide. Methods for using the inventive constructs for regulating gene expression are provided, along with transgenic plants comprising the inventive constructs.
    Type: Grant
    Filed: November 7, 2003
    Date of Patent: April 29, 2008
    Assignee: Arborgen, LLC
    Inventors: Jonathan Phillips, Clare Eagleton
  • Patent number: 7365187
    Abstract: In a method for amplifying a DNA, comprising performing PCR using a sense primer and an antisense primer, PCR is performed in the presence of an additional sense primer comprising the sense primer and an oligodeoxyribonucleotide having a first additional sequence and ligated to the 5? end of the sense primer and an additional antisense primer comprising the antisense primer and an oligodeoxyribonucleotide having a second additional sequence complementary to the first additional sequence and ligated to the 5? end of the antisense primer; a Tm value of the additional sequences is lower than Tm values of the sense primer and the antisense primer; and annealing temperature in PCR is initially set to be a temperature at which the additional sequences do not anneal and changed in the course of PCR to a temperature at which the additional sequences anneal to each other.
    Type: Grant
    Filed: March 5, 2004
    Date of Patent: April 29, 2008
    Assignee: Arkray, Inc.
    Inventors: Satoshi Hashiguchi, Ken Inose
  • Patent number: 7365188
    Abstract: The present invention provides a process for producing a N4-acyl-5?-deoxy-5-fluorocytidine compound of the formula: where R2 is alkyl, cycloalkyl, aralkyl, aryl, or alkoxy.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: April 29, 2008
    Assignee: Roche Colorado Corporation
    Inventors: Christopher R. Roberts, Jim-wah Wong
  • Patent number: 7365189
    Abstract: The present invention relates to nucleic acid molecules encoding enzymes which are involved in the starch synthesis in plants. These enzymes are starch synthases from wheat. The invention further relates to vectors and host cells containing said nucleic acid molecules, in particular transformed plant cells and plants regenerated from these cells, which exhibit an increased or a reduced activity of the described starch synthases.
    Type: Grant
    Filed: April 5, 2004
    Date of Patent: April 29, 2008
    Assignee: Hoechst Schering AgrEvo GmbH
    Inventors: Martina Block, Horst Lorz, Stephanie Lutticke, Lennart Walter, Claus Frohberg, Jens Kossmann
  • Patent number: 7365190
    Abstract: New crosslinked polysaccharides useful as absorbents or superabsorbents alone or in a mixture are obtained by reacting polysaccharides (preferably containing carboxylates groups) with at least one crosslinker selected in the group constituted by activated polyethylene glycols such as for example halogenated (Cl, Br, I), mesylated, tosylated, or triflated activated polyethylene glycols.
    Type: Grant
    Filed: November 9, 2001
    Date of Patent: April 29, 2008
    Assignee: Archer-Daniels-Midland Company
    Inventors: Claude Couture, David Bergeron, Frédéric Picard
  • Patent number: 7365191
    Abstract: This invention involves a type of oligosacoharides and its their sulfate derivatives. The backbone of the oligosaccharides consists of 4 to 14 glucose residues, while the side chains contain 0 to 4 glucose residues. There are at least one 1->3? linkage and ?-(1->3)-Iinkage or ?-(1->4) linkage in the backbone. These oligosaccharides, and their sulfates have immune enhancing, antitumor, and antiviral activities. They can be used in immune enhancing, antitumor, and antiviral medicine compounds that would be used as therapeutic treatments.
    Type: Grant
    Filed: July 5, 2002
    Date of Patent: April 29, 2008
    Assignee: Shanghaimed Co., Ltd
    Inventors: Fanzuo Kong, Jun Ning, Jianxin Gu
  • Patent number: 7365192
    Abstract: The present invention provides a preparation method of valienamine from acarbose or acarbose derivatives using organic acid TFA (trifluoroacetic acid). By using the method of the present invention, valienamine, the core precursor of voglibose which is a strong retardant of ?-glucosidase and which is used for the cure of diabetes, can be produced in large quantities by using selective hydrolysis from acarbose or acarbose derivatives using TFA.
    Type: Grant
    Filed: November 23, 2002
    Date of Patent: April 29, 2008
    Assignee: B T Gin, Inc.
    Inventors: Youl Her, Jin-Hwan Oh
  • Patent number: 7365193
    Abstract: Compounds of formula (I) wherein A and B are amine-substituted sidechains, Y1 and Y2 form various tricyclic cores, Xa and Xb are C, CH, or N, as defined herein, and Rx is an optional substituent. Compounds and compositions of formula (I) are contemplated as well as methods for treating conditions or disorders prevented by or ameliorated by ?7nAChR ligands that encompass compounds of formula (I) and other tricyclic derivatives. Methods of using amino-substituted tricyclic derivatives also are described herein.
    Type: Grant
    Filed: February 4, 2005
    Date of Patent: April 29, 2008
    Assignee: Abbott Laboratories
    Inventors: Michael R. Schrimpf, Kevin B. Sippy, Jianguo Ji, Tao Li, Jennifer M. Frost, Clark A. Briggs, William H. Bunnelle
  • Patent number: 7365194
    Abstract: A dimer of phenazine-1-carboyxlic acid natural products from fluorescent pseudomonad bacterium and a method of preparing a dimer of phenazine-1-carboxylic acid natural product are disclosed herein. The method comprises growing the bacterium in a water based liquid medium under favorable pH and temperature with continuous agitation, extracting the dimer of phenazine-1-carboyxlic acid natural product from the medium by centrifugation using organic solvents, filtering the resultant emulsion to separate the aqueous layer in a separation funnel, isolating the crude dimer of phenazine-1-carboyxlic acid natural product from the organic layer by evaporating the organic solvent, and purifying the dimer of phenazine-1-carboxylic acid natural product by chromatography.
    Type: Grant
    Filed: July 9, 2004
    Date of Patent: April 29, 2008
    Assignee: Pondicherry University and Department of Biotechnology
    Inventors: Natarajan Sakthivel, Radhakrishnan Sunish Kumar
  • Patent number: 7365195
    Abstract: The invention relates to a process for purifying caprolactam, said process comprising (a) subjecting the caprolactam to a hydrogenation by treating the caprolactam with hydrogen in the presence of a heterogeneous nickel containing hydrogenation catalyst, (b) distilling at least a portion of the hydrogenated caprolactam in a distillation column containing nickel in an amount sufficiently low such that ?PANNi?3, wherein ?PANNi=?PAN??PANNi=0, ?PAN=increase of the PAN number of caprolactam during distilling, ?PANNi=0 increase of the PAN number of caprolactam during distilling under the same conditions in a distillation column free of nickel. Nickel is removed from the caprolactam solution prior to the distillation step.
    Type: Grant
    Filed: July 16, 2004
    Date of Patent: April 29, 2008
    Assignee: DSM IP Assets B.V.
    Inventors: Joannes Albertus Wilhelmus J. A. W. Lemmens, Theodorus Maria T. M. Smeets, Paul Maria P. M. Brandts, Koen Harry Maria K. H. M. Ceyssens
  • Patent number: 7365196
    Abstract: A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: April 29, 2008
    Assignees: Merck Sharp & Dohme Ltd., Merck Frosst Canada & Co.
    Inventors: Patrice Charles Belanger, Ian James Collins, Joanne Claire Hannam, Timothy Harrison, Stephen John Lewis, Andrew Madin, Edward Giles McIver, Alan John Nadin, Joseph George Neduvelil, Mark Steven Shearman, Adrian Leonard Smith, Timothy Jason Sparey, Graeme Irvine Stevenson, Martin Richard Teall
  • Patent number: 7365197
    Abstract: This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the treatment of a variety of diseases that are a result of deregulation of these PTK's, and more specifically, are anti-cancer agents and are useful for the treatment of cancer in mammals. In addition, the compounds derived from this invention are useful for the treatment of polycystic kidney disease in mammals.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: April 29, 2008
    Assignee: Wyeth
    Inventors: Dan Maarten Berger, Gary Harold Birnberg, Yanong Wang
  • Patent number: 7365198
    Abstract: Provided is an organic light emitting device capable of emitting light with high efficiency by incorporating a silyl compound in which a silyl group is directly bonded to an anthracene ring particularly into its light emitting layer.
    Type: Grant
    Filed: February 22, 2007
    Date of Patent: April 29, 2008
    Assignee: Canon Kabushiki Kaisha
    Inventors: Akihito Saitoh, Masataka Yashima
  • Patent number: 7365199
    Abstract: A dye-forming coupler of formula (I), a silver halide photographic light-sensitive material containing the coupler, and an azomethine dye compound derived from the coupler: wherein Q is a residue that forms, together with the —N—C?N— moiety, a nitrogen-containing 6-membered ring; RA is a certain alkyl group having at least 7 carbon atoms, or -L-R1; X is an aryl group; Y is a hydrogen atom, or a group capable of being split-off upon a coupling reaction; wherein, when RA is -L-R1, L is a divalent linking group, and R1 is a substituent; and -L-R1 does not represent an alkyl, alkenyl, alkynyl, or aryl group, and -L-R1 does not represent a heterocyclic group that bonds, with a carbon atom therein, to the nitrogen atom of the nitrogen-containing 6-membered ring formed by Q and the —N—C?N— moiety.
    Type: Grant
    Filed: April 19, 2002
    Date of Patent: April 29, 2008
    Assignee: FUJIFILM Corporation
    Inventors: Shigeki Uehira, Kiyoshi Takeuchi
  • Patent number: 7365200
    Abstract: Inhibitors of macrophage migration inhibitory factor having a thienopyridinone backbone are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with macrophage migration inhibitory factor activity. The inhibitors of macrophage migration inhibitory factor have the following structures: including forms such as stereoisomers, free forms, pharmaceutically acceptable salts or esters thereof, solvates, or combinations of such forms, wherein n, R1, R2, R3, X, and Y are as defined herein. Compositions comprising an inhibitor of macrophage migration inhibitory factor in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: April 29, 2008
    Assignee: Avanir Pharmaceuticals
    Inventors: Jagadish Sircar, Sunil Kumar K. C., Timothy James Davis, Wenbin Ying
  • Patent number: 7365201
    Abstract: A process for the preparation of the boron difluoride chelate of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolone carboxylic acid via: (a) the reaction of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolone carboxylic acid ethyl ester with, (b) fluoroboric acid in the presence of poly(methylhydrosiloxane) or hexamethyldisiloxane.
    Type: Grant
    Filed: March 2, 2006
    Date of Patent: April 29, 2008
    Assignee: Apotex Pharmachem Inc.
    Inventors: Zhi-Xian Wang, Murali Kondamreddy, Joseph DiMartino, Bhaskar Reddy Guntoori
  • Patent number: 7365202
    Abstract: Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner.
    Type: Grant
    Filed: December 4, 2006
    Date of Patent: April 29, 2008
    Assignee: Merck & Co., Inc.
    Inventors: Lushi Tan, Robert S. Meissner, Wenjie Li, James J. Perkins, Aaron S. Cote, Joyce Stellabott, Yuan-Hon Kiang
  • Patent number: 7365203
    Abstract: The present invention provides a process for the preparation of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile comprising the steps and products disclosed within this application.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: April 29, 2008
    Assignee: Wyeth
    Inventors: Sylvain Daigneault, Ronald Stanley Michalak, Michel Bernatchez
  • Patent number: 7365204
    Abstract: An process for the preparation of pyridine and/or picolines is disclosed. The process comprises contacting a mixture of carbonyl compound with ammonia in the presence of surface-passivated titanium-silicate catalyst in gas phase at a temperature ranging between 300-500° C., at gas space velocity in the range of 300 to 3000 h?1 and at a pressure ranging between 1 to 10 atmosphere, condensing and separating the products by conventional methods and if desired, further purifying the product using well known conventional methods.
    Type: Grant
    Filed: March 22, 2004
    Date of Patent: April 29, 2008
    Assignees: Council of Scientific and Industrial Research, Jubliant Organosys Limited
    Inventors: Rajiv Kumar, Praphulla Narahar Joshi, Gopal Moreshwar Chaphekar, Prashant Suresh Niphadkar, Ashutosh Agarwal, Pradeep Kumar Verma, Kumar Samir Singh
  • Patent number: 7365205
    Abstract: A compound represented by the general formula (1): Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4??(1) wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 is a group in which Q5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T0 and T1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof.
    Type: Grant
    Filed: March 20, 2002
    Date of Patent: April 29, 2008
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Toshiharu Ohta, Satoshi Komoriya, Toshiharu Yoshino, Masatoshi Nagamochi, Makoto Ono
  • Patent number: 7365206
    Abstract: The present invention relates to a process for stereoselective synthesis of substituted sulfoxides either as a single enantiomer or in an enantiomerically enriched form. Thus, 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]thio]-1H-benzimidazol is reacted with (R)-camphorsulfonyl chloride to form a mixture of 1-(R)-camphorsulfonyl-5-(and 6-)methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methylthio]-1H-benzimidazole, oxidized to obtain a diastereomeric excess of 1-(R)-camphorsulfonyl-(5- and 6-)-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole over 1-(R)-camphorsulfonyl-(5- and 6-)-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(R)-sulfinyl]-1H-benzimidazole, the diastereomers are separated by fractional crystallization and the separated 1-(R)-camphorsulfonyl-(5- and 6-)-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole is deprotected to give esomeprazole.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: April 29, 2008
    Assignee: Hetero Drugs Limited
    Inventors: Bandi Parthasaradhi Reddy, Kura Rathnakar Reddy, Rapolu Raji Reddy, Dasari Muralidhara Reddy
  • Patent number: 7365207
    Abstract: The present invention is concerned with a novel process for the preparation of compounds of formula I comprising catalytic asymmetric hydrogenation of a compound of formula (II) in the presence of a catalyst comprising ruthenium and a chiral diphosphine ligand or comprising rhodium and a chiral diphosphine ligand, wherein R1, R2, R3 and R4 are as defined in the specification and claims. The compounds of formula I and the corresponding salts and/or esters are pharmaceutically active substances.
    Type: Grant
    Filed: June 8, 2007
    Date of Patent: April 29, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Kurt Puentener, Michelangelo Scalone
  • Patent number: 7365208
    Abstract: A method for preparing irbesartan and intermediates thereof.
    Type: Grant
    Filed: March 20, 2007
    Date of Patent: April 29, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Edgar I. Miranda, Cornelis Vlaar, Jingyang Zhu
  • Patent number: 7365209
    Abstract: Nitrogen heterocycle biaryls having a carboxylate terminus are useful for treating endometriosis, osteoporosis, restenosis following angioplasty, rheumatoid arthritis, cancer, macular degeneration and obesity. Compounds of formula: are disclosed.
    Type: Grant
    Filed: February 10, 2004
    Date of Patent: April 29, 2008
    Assignee: Pharmacopeia, Inc.
    Inventors: Jeffrey John Letourneau, Vidyahar Paradkar, Michael H. J. Ohlmeyer, Lawrence W. Dillard, John J. Baldwin, Christopher Mark Riviello, Angela Wong, Yaing Rong
  • Patent number: 7365210
    Abstract: The invention relates to a process for preparing chiral imidazolidin-2-ones of the formula I in which R1 is C1-C8-alkyl, cyclohexyl, phenyl, a C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy-, C1-C6-alkylmercapto- or CF3-substituted phenyl radical, naphthyl or a C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy- or CF3-substituted naphthyl radical, R2 is C1-C8-alkyl, C2-C8-alkenyl, cyclohexyl, phenyl or a phenyl-C1-C6-alkyl radical which may be substituted by a nitro, C1-C6-alkoxy, methylenedioxy or CF3 radical, and R3 is C1-C12-alkyl, C2-C8-alkenyl, cyclohexyl, phenyl or a C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy-, methylenedioxy-, dialkylamino- or CF3-substituted phenyl radical, by reacting a compound of the formula II or the salt thereof in which R1, R2 and R3 have the abovementioned meaning, with urea in the presence of an involatile ammonium salt, wherein the reaction is carried out in the presence of an aprotic polar organic solvent.
    Type: Grant
    Filed: April 8, 2003
    Date of Patent: April 29, 2008
    Assignee: BASF Aktiengesellschaft
    Inventors: Hansgeorg Ernst, Jürgen Koppenhöfer, Daniela Klein
  • Patent number: 7365211
    Abstract: This invention relates to a method for modulating ?2 subtype GABAA receptors with heterocyclic compounds of formula I, and salts, solvates and prodrugs thereof. The invention further relates to said heterocyclic compounds and pharmaceutical compositions containing said compounds.
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: April 29, 2008
    Assignee: Roche Palo Alto LLC
    Inventors: Xao-Fa Lin, David Garrett Loughhead, Sanja Novakovic, Counde O'Yang, Michael Soth, David George Putman
  • Patent number: 7365212
    Abstract: A process for the in situ preparation of chiral compounds derived from oxazaborolidine-borane complexes, wherein a metal borohydride, a Lewis base and an inorganic acid ester are brought together and an optically active amino alcohol and optionally a halide are then added. The compound obtained is a complex that is useful as a catalyst in asymmetric reduction reactions. The reaction is performed by adding the substance to be reduced, particularly prochiral ketones or ether oximes, in order to synthesize chiral alcohols or chiral amines.
    Type: Grant
    Filed: October 11, 2004
    Date of Patent: April 29, 2008
    Assignee: ZaCh System S.p.A.
    Inventors: Alain Burgos, Blandine Bertrand, Stéphane Frein, Jean-François Pluvie, Sonia Roussiasse
  • Patent number: 7365213
    Abstract: [Problems] To provide a novel alkoxysilane having a diol protected, an organosilicon resin which has a diol and the composition of which can be easily regulated, and to processes for producing these. [Means for solving problems] The alkoxysilane is an organosilicon compound represented by the following formula (1). The organosilicon resin having a diol is one obtained by hydrolyzing-condensing this compound with a multifunctional alkoxysilane. (In the formula, each of R1, R2 and R3 is an alkyl group or an alkoxy group each having carbon number from 1 to 6. R4 is an alkylene group having carbon number from 2 to 6. Z is an alkylene group having carbon number from 1 to 3.) The alkoxysilane of the present invention can be produced by a hydrosilylation reaction of a compound represented by the following formula (4) and a silane compound R1R2R3SiH. (In the formula, Z is an alkylene group having carbon number from 1 to 3 and R5 has a carbon-carbon double bond at the terminal.
    Type: Grant
    Filed: February 9, 2005
    Date of Patent: April 29, 2008
    Assignee: Toagosei Co., Ltd.
    Inventors: Katsuhiko Komuro, Hiroshi Suzuki
  • Patent number: 7365214
    Abstract: The present invention provides an improved process for the preparation of cyclic carbonates which comprises reacting an olefins or its epoxide with carbon dioxide or a mixture of oxygen-containing compound and carbon dioxide, in the presence of zeolite-based catalyst and a Lewis base co-catalyst, at a minimum pressure of 30 psig and temperature between 40 to 120° C. for 0.5 to 4 hrs., separating the catalyst and recovering the corresponding cyclic carbonate formed by conventional methods.
    Type: Grant
    Filed: September 29, 2003
    Date of Patent: April 29, 2008
    Assignee: Council of Scientific and Industrial Research
    Inventors: Darbha Srinivas, Rajendra Srivastava
  • Patent number: 7365215
    Abstract: The present invention relates to a process for preparing 4-aminotetrahydropyran compound and an acid salt thereof represented by the formula (1): wherein R represents a hydrogen atom or a hydrocarbon group, which comprises subjecting a 4-hydrazinotetrahydropyran compound or an acid salt thereof represented by the formula (2): wherein R has the same meaning as defined above, to decomposition reaction in the presence of at least one compound selected from Raney nickel, a noble metal catalyst and a metal oxide, and a synthetic intermediate thereof and a process for preparing the same.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: April 29, 2008
    Assignee: Ube Industries, Ltd.
    Inventors: Shigeyoshi Nishino, Kenji Hirotsu, Hidetaka Shima, Keiji Iwamoto, Takashi Harada, Shinobu Suzuki
  • Patent number: 7365216
    Abstract: The invention relates to a process for the manufacture of salts of citalopram in high purity. By the careful selection of solvents and the careful manipulation of the pH value, citalopram salts may be isolated in the absence of 5-chlorocitalopram, 5-bromocitalo-pram, desmethyl-citalopram and 5-carobxyamide citalopram.
    Type: Grant
    Filed: April 18, 2002
    Date of Patent: April 29, 2008
    Assignee: Matrix Laboratories Limited
    Inventors: Jyothi Basu Abbineni, Hari Babu Bodepudi, Satyanarayana Chava, Venkata Ramana Rao Chunchu
  • Patent number: 7365217
    Abstract: A process is disclosed for reacting an olefin, hydrogen, and oxygen in a reactor in the presence of an epoxidation catalyst comprising a transition metal zeolite and a noble metal to produce a product stream comprising an epoxide and an alkane. The alkane is separated and oxidized to at least one oxygenated product.
    Type: Grant
    Filed: January 25, 2006
    Date of Patent: April 29, 2008
    Assignee: Lyondell Chemical Technology, L.P.
    Inventor: Roger A. Grey
  • Patent number: 7365218
    Abstract: The present invention provides an improved process for the preparation of Guggulsterones which comprises epoxidising 16-dihydropegnenolone acetate (16 DPA) by reacting 16DPA with hydrogen peroxide reagent adduct in the presence of a co-base in a polar solvent to obtain 3 ? hydroxy-16 ?, 17-oxido-5 pregnen-20-one, converting the 3 ? hydroxy-16?, 17-oxido-5-pregnen-20-one by reacting with hydrazine in the presence of a strong base at refluxing temperature followed by oxidation to obtain desired guggulsterones viz. to 5, 17-(20)-cis and trans pregnadiene-3 ?, 16-diol of the formula Ia and Ib.
    Type: Grant
    Filed: March 20, 2003
    Date of Patent: April 29, 2008
    Assignee: Council of Scientific and Industrial Research
    Inventors: Ram Pratap, Dharmendra Pratap Singh, Raghavendra Pal, Satyawan Singh
  • Patent number: 7365219
    Abstract: The invention relates to a novel extraction method for obtaining at least one unsaturated, optionally derivatized compound, from mixtures of said compounds with other less saturated constituents, e.g. for obtaining polyunsaturated fatty acids or the derivatives thereof from mixtures with saturated and/or less unsaturated, optionally derivatized fatty acids, by means of selective complexation with a cation exchanger which is partially or fully charged with silver ions, and subsequent decomplexation.
    Type: Grant
    Filed: June 5, 2002
    Date of Patent: April 29, 2008
    Assignee: Nutrinova Nutrition Specialties & Food Indredients GmbH
    Inventors: Dirk Fabritius, Silke Reimann, Doreen Neumann, Daniel Minoer
  • Patent number: 7365220
    Abstract: A process is provided for separating a mixture of alkoxysilanes and alkanol, e.g., the crude product effluent of the Direct Reaction of silicon metal with alkanol, which comprises: a) introducing a mixture of alkoxysilane(s) and alkanol to a separation unit possessing a separation membrane having a first surface and an opposing second surface; b) contacting the mixture of alkoxysilane(s) and alkanol with the first surface of the separation membrane whereby one or more components of the mixture selectively absorb into the first surface and permeate therethrough to the second surface under the influence of a concentration gradient across the membrane thereby separating the mixture into an alkanol-enriched permeate fraction and an alkanol-deficient retentate fraction or an alkoxysilane-enriched permeate fraction and an alkoxysilane-deficient retentate fraction; and, c) recovering the permeate fraction.
    Type: Grant
    Filed: September 29, 2005
    Date of Patent: April 29, 2008
    Assignee: Momentive Performance Materials Inc.
    Inventors: Kenrick Martin Lewis, Hua Wang
  • Patent number: 7365221
    Abstract: Betulin and dihydrobetulin acyl derivatives according to the present invention have been found to have potent anti-HIV activity. The compounds of the present invention have Formula I as described herein, or pharmaceutically acceptable salts thereof; wherein R1 is a C2-C20 substituted or unsubstituted carboxyacyl or ester thereof; R2 is hydrogen, halogen, hydroxyl or —OR3, R3 is C2-C20 substituted or unsubstituted carboxyacyl; and R4 is hydrogen or C(C6H5)3; wherein the dashed line represents an optional double bond between C20 and C29.
    Type: Grant
    Filed: June 18, 2004
    Date of Patent: April 29, 2008
    Assignees: Panacos Pharmaceuticals, Inc., The University of North Carolina at Chapel Hill, Niigata University of Pharmacy and Applied Life Sciences
    Inventors: Graham P. Allaway, Carl T. Wild, Yoshiki Kashiwada, Kuo-Hsiung Lee
  • Patent number: 7365222
    Abstract: Bicyclic cyclopropane derivatives of the general Formula (I) in which n+m is 0 to 8; r is 1 to 4; R1 is absent or is a C1-C20 alkylene radical which can be interrupted by O or S, a cycloaliphatic C4-C12 radical, a bicyclic C4-C12 radical, a C6-C14 arylene or C7-C20 alkylenearylene radical; R2 is for r=1 a C1-C20 alkyl radical which can be interrupted by O or S, a cycloaliphatic C4-C12 radical, a bicyclic C4-C12 radical, a C6-C14 aryl or a C7-C20 alkylaryl radical; is for r>1 an r-times substituted aliphatic C1 to C20 radical which can be interrupted by O or S, a cycloaliphatic C4-C12 radical, an aromatic C6-C14 radical or aliphatic-aromatic C7-C20 radical; X is absent or is —CO—O—, —CO—NH— or —O—CO—NH—, and Y is CH2, O or S which is suitable in particular for the preparation of dental materials.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: April 29, 2008
    Assignee: Ivoclar Vivadent AG
    Inventors: Norbert Moszner, Armin de Meijere, Frank Zeuner, Urs Karl Fischer
  • Patent number: 7365223
    Abstract: The invention provides novel methods for selective targeting of chemical compounds to cells undergoing a death process, in particular apoptosis, and to platelets undergoing activation during blood coagulation. The invention further provides compounds to be used in said methods for medical practice, for diagnostic and therapeutic purposes.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: April 29, 2008
    Assignee: NST NeuroSurvival Technologies Ltd
    Inventors: Ilan Ziv, Anat Shirvan
  • Patent number: 7365224
    Abstract: A pharmaceutical composition comprising a compound of formula (1) in polymorphic crystalline Form A: together with a pharmaceutically acceptable carrier or excipient, wherein the compound of formula (1) is present in polymorphic Form A (see, e.g., FIG. 6) substantially free of other polymorphic forms.
    Type: Grant
    Filed: December 29, 2005
    Date of Patent: April 29, 2008
    Assignee: Medicinova, Inc.
    Inventors: Kenneth Walter Locke, David Gregory Roe
  • Patent number: 7365225
    Abstract: The present invention is related to aryl dicarboxamides of formula (I) and use thereof for the treatment and/or prevention of obesity and/or metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholes-terolemia, polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of aryl dicarboxamides of formula (I) to modulate, notably to inhibit the activity of PTPs.
    Type: Grant
    Filed: July 20, 2004
    Date of Patent: April 29, 2008
    Assignee: Laboratoires Serono SA
    Inventors: Russel J. Thomas, Dominique Swinnen, Jean-Francois Pons, Agnes Bombrun
  • Patent number: 7365226
    Abstract: A process for the preparation of gabapentin comprising the passage of a salt of the same through a ionic exchange resin of strong cationic type, the elution of the gabapentin which has fixed onto the column and the crystallization from organic solvent, characterized in that the resin is regenerated by using a mineral acid in a molar quantity between 50 and 90%, is described.
    Type: Grant
    Filed: December 14, 2004
    Date of Patent: April 29, 2008
    Assignee: Zach System S.p.A.
    Inventors: Roberto Giovanetti, Andrea Nicoli, Angelo Restelli, Livius Cotarca
  • Patent number: 7365227
    Abstract: A process for the purification of gabapentin by treatment of a crude aqueous gabapentin hydrochloride solution with a strong cationic ion exchange resin.
    Type: Grant
    Filed: March 28, 2006
    Date of Patent: April 29, 2008
    Assignee: ZACH System S.p.A.
    Inventors: Vincenzo Cannata, Andrea Nicoli, Francesco Corcella