Abstract: Provided are novel crystalline forms of gatifloxacin, denominated forms L, M, P, Q, S, and T1, and methods for making them. Also provided are methods of transforming the novel crystalline forms of gatifloxacin of the present invention to other crystalline forms of gatifloxacin.

Abstract: Tertiary amine compounds that bind chemokine receptors such as CXCR4 and CCR5 are disclosed.

Abstract: An injectable composition comprises a benzimidazole compound having an antiulcer action and a strong alkali (e.g., an alkali metal hydroxide such as sodium hydroxide) in a proportion of about 1 equivalent of the latter relative to 1 mol of the former, and is substantially free from a nonaqueous solvent. The injectable composition may comprise N-methylglucamine, and a saccharide (such as mannitol). The injectable composition may be a freeze-dried preparation. The freeze-dried preparation is dissolvable in or dilutive with a distilled water for injection or an infusion solution without a nonaqueous solvent. The injectable composition is useful as an antiulcer agent.

Abstract: A 5-membered cyclic compound of the formula: wherein X is oxygen or sulfur, R1 is hydrogen, substituted or unsubstituted alkyl, etc., R2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, etc., Y1 is a direct bond, substituted or unsubstituted alkylene, —CO(CH2)n—, etc., the wavy line means (E)-configuration or (Z)-configuration, R3 is substituted or unsubstituted aryl, etc., Y2 is substituted or unsubstituted alkylene, etc., R4 is hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted alkyl, etc., R5 is hydrogen, etc., or a salt thereof, these compound being able to inhibit infiltration of leukocytes such as eosinophils and lymphocytes, by which being useful for the treatment of various kinds of inflammation.

Abstract: Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.

Abstract: Benzamidine derivatives of the following formulae or analogs thereof, i.e., pharmaceutically acceptable salts thereof, are provided.

Abstract: This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

Abstract: Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, and compounds as shown in (I) wherein C is for example wherein A and B are independently selected from R2a to R3b are independently selected from hydrogen and fluorine; R1a and R1b are independently selected from, for example, hydroxy, —NHC(?W)R4, wherein W is O or S; R4 is, for example, hydrogen, amino, (1-4C)alkyl; HET-1 is, for example, a C-linked 5-membered heteroaryl ring; HET-2 is, for example, an N-linked 5-membered, fully or partially unsaturated heterocyclic ring; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.

Abstract: A neurotrophin production/secretion promoting agent which comprises an azole derivative of the formula: wherein R1 represents a halogen atom, a heterocyclic group which may optionally be substituted, a hydroxy group which may optionally be substituted, a thiol group which may optionally be substituted, or an amino group which may optionally be substituted; A represents an acyl group which may optionally be substituted, a heterocyclic group which may optionally be substituted, a hydroxy group which may optionally be substituted, or a carboxyl group which may optionally be esterified or amidated; B represents an aromatic group which may optionally be substituted; X represents oxygen atom, sulfur atom, or nitrogen atom which may optionally be substituted; and Y represents a divalent hydrocarbon group or heterocyclic group, or a salt thereof; which is useful as an agent for preventing or treating neuropathy.

Abstract: Compounds of Formula 1 where the variables have the meaning defined in the specification are agonists of alpha2 adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors. Additionally some of the claimed compounds have no or only minimal cardivascular and/or sedatory activity. The compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2 adrenergic receptors. Compounds of Formula 1 which have no significant cardiovascular and/or sedatory activity are useful for treating pain and other conditions with minimal side effects.

Abstract: The present invention is directed to a compound, {2-Methyl-4-[3-methyl-1-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethylsulfanyl]-phenoxy}-acetic acid and pharmaceutical uses thereof.

Abstract: The invention relates to the use of structural analogues of distamycin having the general formula (I), (II), (III), (IV) or (V) or their pharmaceutically acceptable salts, for the preparation of a medicament for the therapeutic treatment of ?-thalassaemia.

Abstract: A compound including at least one type of an optionally substituted indolocarbazole moiety and at least one divalent linkage.

Abstract: The present invention relates to compounds of formula I: wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification and claims, which compounds are active on the GABAB receptor and are useful in the control or prevention of CNS illnesses, especially of illnesses and disorders comprising anxiety, depression, epilepsy, schizophrenia, and cognitive disorders.

Abstract: The present invention relates to a method of treatment of hot flushes with a 5-HT2C receptor agonist and in particular to the use of the selective 5-HT2C receptor agonists 1-[6-chloro-5-(trifluoromethyl)-2-pyridinyl]-piperazine and (S)-(+)-3-[(2,3-dihydro-5-methoxy-1H-inden-4-yl)oxy-pyrrolidine or pharmaceutically acceptable acid addition salts thereof for the manufacture of a pharmaceutical formulation adapted for the treatment of hot flushes.

Abstract: A composition for use in making commercial food and skin products comprising S-equol or mixtures, including both a non-racemic mixture and a racemic mixture, of S-equol and R-equol. The composition can be used to make articles of commerce such as food supplements, pharmaceuticals, and medicaments. The compositions are useful in a method of delivering S-equol to a mammal to prevent or treat a disease or associated condition, including hormone-dependent diseases or conditions such as cardiovascular disease, lipid disorder, osteopenia, osteoporosis, liver disease, and acute ovarian estrogen deficiency. The S-equol enantiomer can be produced in a biological synthesis from the metabolism of an isoflavone by an organism.

Abstract: Novel benzopyran analogs are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.

Abstract: Therapeutic combinations useful in the treatment or prevention of depression or other mood disorders, to pharmaceutical compositions containing said combinations, and to their use in the treatment or prophylaxis of depression or other mood disorders are provided. Such compounds are of formula I: or a pharmaceutically acceptable salt thereof, wherein each of R1, R2, R3, n, y, and Ar are as defined and described herein.

Abstract: Diabetes treatments comprising, as effective ingredients, biguanide derivatives represented by the following general formula (1), or salts thereof. (wherein R1, R2 and R3 may be the same or different and each represents one selected from the group consisting of hydrogen, optionally substituted lower alkyl groups and optionally substituted lower alkylthio groups).

Abstract: The present invention provides uses of compounds that bind selectively to cells undergoing perturbations and alterations of their normal membrane organization, while binding to a lesser degree to cell having membranes of normal organization. These compounds are termed perturbed-membrane-binding compounds (PMBC). The PMBC group of compounds includes new compounds and also known compounds.

Abstract: The subject invention provides a method for treating amyotrophic lateral sclerosis (ALS) in a subject in need of such treatment comprising administering to the subject R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof alone or in combination with 2-amino-6-trifluoromethoxy benzothiazole in amounts effective to treat ALS in the subject.

Abstract: Radiation curable compositions with a polymeric co-initiator are disclosed comprising a dendritic polymer core with at least one co-initiating functional group as an end group. The dendritic polymeric core is preferably a hyperbranched polymer. Industrial applications include varnishes, lacquers and printing inks. The polymeric co-initiator is especially useful in radiation curable inkjet ink.

Abstract: Dental composite filler materials comprise particles coated via an atomic layer deposition (ALD) process. The coating material has a different composition than the core particle. The difference in composition permits fine control over the refractive index of the coated particles, allowing good matching tooth enamel and to the binder materials used in the composite.

Abstract: An ink set comprising a black ink and a color ink, wherein the black ink comprises an aqueous dispersion of water-insoluble vinyl polymer particles containing an oil-soluble black dye or carbon black, the vinyl polymer particles have an ionicity opposite to that of the color ink, and the vinyl polymer comprises a water-insoluble vinyl polymer prepared by copolymerizing (a) a salt forming group-containing monomer, (b) a monomer represented by the formula (I): CH2?C(R1)COO(R2O)pR3 ??(I) wherein R1 is hydrogen atom or a lower alkyl group, R2 is a divalent hydrocarbon group which may have a hetero-atom, R3 is a monovalent hydrocarbon group which may have a hetero-atom, and p is a number of 1 to 60, (c) a macromer, and (d) a monomer copolymerizable with these monomers. The ink set can be used as an ink set for inkjet recording, which is excellent in not only fixing abilities and water resistance, but also bleeding resistance and jettability, and can form very clear printouts.

Abstract: A HAPs-free ink jet ink includes a pigment; a binder comprising vinyl chloride-vinyl acetate copolymer; and a HAPs-free solvent component comprising 1-methoxy-2-propanol acetate, a dispersing solvent selected from cyclohexanone, n-propyl acetate, n-butyl acetate, diisobutyl ketone, isobutyl acetate, amyl acetate, and combinations of these, and a diluent solvent selected from dipropylene glycol methyl ether, dipropylene glycol methyl ether acetate, tripropylene glycol methyl ether, ethylene glycol diacetate, propylene glycol n-butyl ether, propylene glycol n-propyl ether, and combinations of these. The ink has excellent stability and printing properties. Printing with the ink avoids release of HAPs while allowing long print runs with low maintenance.

Abstract: An oxygen absorber of the present invention includes at least one compound represented by Formula (1): and an oxidizable polymer. R1 and R2 each independently indicates a hydrogen atom or an organic group. R1 and R2 may form a ring together with carbon atoms to which they are bonded. R1 and/or R2 may form a carbon-carbon double bond with carbon atoms to which they are bonded.

Abstract: A thermoplastic polymer comprising a fluorochemical ester composition of formula I: C4F9SO2N(Q1)(CH2)a—O—C(O)—(CH2)n—C(O)O(CH2)bNQ2SO2C4F9 ??(I) wherein Q1 and Q2 which may be the same or different are each a hydrogen or an alkyl group of 1 to 4 carbon atoms; a is an integer from 2 to 11; b is an integer from 2 to 11; and n is at least 10.

Abstract: An organopolysiloxane composition for bonding to magnesium alloys comprises (A) 100 parts by weight of an organopolysiloxane of the following general formula (1) and/or (2) wherein R may be the same or different and represents a substituted or unsubstituted monovalent hydrocarbon group having 1 to 10 carbon atoms, and n is an integer of at least 10, X represents an oxygen atom or an alkylene group having 2 to 5 carbon atoms, and m independently represents an integer of 0 or 1, (B) 0.1 to 50 parts by weight of an organosilicon compound having at least three hydrolyzable groups bonded to silicon atoms in one molecule and/or a partial hydrolyzate thereof, and (C) 0.1 to 15 parts by weight of an acidic silane coupling agent.

Abstract: An aqueous dispersion type pressure-sensitive adhesive composition contains a polyalkylene glycol having a weight-average molecular weight of from 20,000 to 5,000,000 or at least one hydrophilic polymer selected from the group consisting of polyvinylpyrrolidone, poly(vinyl alcohol)s, and poly((meth)acrylic acid) in an amount of from 0.5 to 15 parts by weight per 100 parts by weight, on a solid basis, of the acrylic or rubber-based pressure-sensitive adhesive composition of the aqueous dispersion type; and a pressure-sensitive adhesive product contains a pressure-sensitive adhesive layer formed from the aqueous dispersion type pressure-sensitive adhesive composition.

Abstract: The disclosure relates to using metallic acrylate compounds such as zinc diacrylate (ZDA), zinc dimethacrylate (ZDMA), among others for curing epoxy functional (and other cross-linking compounds), and to compositions containing such compounds for use in powder coat, film, adhesive, among other applications. ZDA and ZDMA containing compounds can also be supplied as an intermediate product that can cure the epoxy component of the compositions while being substantially free of conventional curing agents.

Abstract: The present invention relates to a cross-linkable or cross-linked rubber composition having improved hysteresis properties in the cross-linked state which is useful for the manufacture of treads for tires. The rubber composition of the present invention comprises at least one diene elastomer having a molar ratio of units originating from conjugated dienes which is greater than 30% and comprising carboxylic acid functions along its chain, and a reinforcing inorganic filler. The present invention further relates to a process for preparing such a cross-linkable or cross-linked rubber composition as well as to a tire having reduced rolling resistance and a tread for a tire where the tread comprises the rubber composition of the present invention.

Abstract: This invention relates to a rubber modified acrylic and/or vinyl resin comprising the mini-emulsion polymerization product of at least one rubber compound substantially dissolved in at least one acrylic monomer and/or vinyl monomer.

Abstract: A grease-like silicone composition comprising at least a liquid organopolysiloxane comprising siloxane units represented by the formula R2SiO2/2, siloxane units represented by the formula RSiO3/2, and siloxane units represented by the formula R3SiO1/2 and a thickening agent. A grease-like silicone composition is provided that is capable of containing a large amount of thickening agent and possesses superior heat resistance.

Abstract: An organometallic polymer material having a -M-O-M- bond (M is a metal atom) and containing a metal alkoxide having only one hydrolyzable group and/or a hydrolysate of the metal alkoxide and preferably further containing an organic acid anhydride and/or an organic acid.

Abstract: A papermaking method and a composition which utilize, as a drainage aid, a water-soluble cationic or amphoteric copolymer prepared via a water-in-oil polymerization technique that, absent a cross-linking agent, is characterized by a Huggins' constant (k?) determined in 0.01M NaCl greater than 0.3 and a storage modulus (G?) at 6.3 Hz greater than 50 Pa.

Abstract: The present invention is directed to a waterborne, UV-curable polyurethane emulsion and the use thereof in producing soft touch coatings. The emulsion is prepared by a) reacting specified hydroxy-functional components with di- and/or polyisocyanates, b) forming a dispersion of the resultant product with water and reacting the dispersion with amine functional materials.

Abstract: A thermoplastic resin component has improved transparency and impact resistance, the thermoplastic resin composed of 5 to 40 parts by weight of a graft copolymer (A) and 95 to 60 parts by weight a copolymer (B), the graft copolymer (A) being prepared by polymerizing at least one selected from the group consisting of alkyl methacrylate, aromatic vinyl, and vinylcyanide with an agglomerated rubber, the copolymer (B) being prepared by polymerizing at least one monomer selected from the group consisting of an aromatic vinyl monomer, an alkyl methacrylate monomer, and a vinylcyanide monomer. The agglomerated rubber is prepared by agglomerating a styrene-diene rubber latex with an acid-group-containing copolymer latex containing unsaturated acid, aromatic vinyl, and alkyl acrylate as the essential components and having a controlled refractive index.

Abstract: Disclosed is a resin composition comprising (A) 100 parts by weight of a base resin comprising a rubber-modified styrene-containing graft copolymer and a styrene-containing copolymer; (B) 0.5-8 parts by weight of an acrylic rubber graft copolymer resin having an average particle size of 0.1-0.5 ?m; and (C) 0.5-8 parts by weight of a graft copolymer resin comprising an ethylene ?-olefinic copolymer rubber having an average particle size of 0.1-0.8 ?m. The thermoplastic resin composition of the present invention greatly improves chemical resistance to insulating materials, such as urethane foam, or foaming agent compounds, such as freon (CFC-11, HCFC-141b, HFC-245fa, HFC-245eb, HFC-245ca, HFC-356mffm) and cyclopentane and offers superior impact strength, whiteness and processability. It can be useful for extrusion sheets of refrigerator interiors.

Abstract: Polyethylene blend compositions suitable for injection molding, injection molded articles, and processes for injection molding articles are provided. The polyethylene compositions include a first polyethylene having a melt index of 0.1 to 3.0 g/10 min and a density of from 0.905 to 0.938 g/cm3; and a second polyethylene having a melt index of 10 to 500 g/10 min and a density of 0.945 to 0.975 g/cm3. The compositions have a density of from 0.920 to 0.973 g/cm3 and a melt index of 2 to 200 g/10 min, and the density of the second polyethylene is from 0.037 to 0.062 g/cm3 greater than the density of the first polyethylene. The compositions exhibit improved physical properties, such as Environmental Stress Crack Resistance, relative to conventional compositions of similar melt index and density. In certain embodiments, the compositions, and articles produced therefrom, also exhibit an improved balance of toughness properties and processability properties.

Abstract: Residual monomer in a polymer matrix may be reduced by a method including admixing a polymer matrix comprising an amount of residual monomer and a conjugated diene. This method can be carried out under reaction conditions such that the amount of residual monomer is reduced. The monomer comprises at least one electron withdrawing substituent and the conjugated diene comprises at least one electron donating substituent. This method is particularly useful for reducing the amount of residual styrene monomer in polystyrene homopolymer and copolymer compositions.

Abstract: The invention relates to polymeric resin blends containing polyelectrolyte resins blended into a polymer or copolymer matrix. Specifically, the polyelectrolyte resins are (co)polymers without hydrolyzable groups. The matrix polymer is a tough, and highly chemical-resistant (co)polymer, preferably a fluoropolymer. The polymeric resin blend is useful for forming films, and especially films useful for MEAs for use in fuel cells.

Abstract: Polyethylene blend compositions suitable for rotomolding, rotomolded articles, and processes for rotomolding articles are provided. The polyethylene compositions include a first polyethylene having a melt index of 0.4 to 3.0 g/10 min and a density of from 0.910 to 0.930 g/cm3; and a second polyethylene having a melt index of 10 to 30 g/10 min and a density of 0.945 to 0.975 g/cm3. The composition has a density of from 0.930 to 0.955 g/cm3 and a melt index of 1.5 to 12 g/10 min, and the first and second polyethylenes differ in density by from 0.030 to 0.048 g/cm3. These compositions exhibit improved physical properties, such as Environmental Stress Crack Resistance and Izod Impact Strength. Articles produced from the compositions may also exhibit improved impact resistance properties, enhanced ductile break properties, and improved deflection resistance, which represents a combination of creep and fatigue resistance.

Abstract: Styrene-free unsaturated polyester resin compositions are provided which have low volatile organic compounds and hazardous air pollutants emissions when these resin compositions are used in open molding applications. A process for the manufacture of these resin compositions is provided.

Abstract: The present invention provides novel, polymeric supports, methods of making, and methods of using the supports, that have a fluorinated, amidated surface. The supports include polymeric microbeads, thin layers or membranes, plates, monoliths and the like. The supports are useful as packing materials for normal phase, reverse phase, and size exclusion chromatography, and provide high speed separation of analytes with excellent resolution.

Abstract: The present invention relates to a composition containing a hydrogenated nitrile-butadiene rubber (HNBR), a peroxide crosslinking system and a resorcinol-formaldehyde resin, to a process for the preparation of the composition, to the use of the composition as an adhesion promoter, and also to a multilayer product containing the composition according to the present invention.

Abstract: A photo-setting and thermosetting resin composition comprises (I) a partial adduct of epoxy resin with unsaturated aliphatic acid, (II) (meth)acrylates, (III) a photocrosslinking agent, (IV) liquid epoxy resin, and (V) a latent curing agent. The resin composition can be easily charged and plugged into a through-hole, does not drip down, and can be effectively photo-set and thermoset. A photo-set product prepared of the resin composition can be easily polished. A plugged-through-hole printed wiring (substrate) board prepared of the resin composition does not cause defects such as hollows, cracks, blisters, peelings and so on, is excellent in solder-resistance, does not corrode a metal part, and can produce an appliance of high reliability and long life which does not occur short circuit and poor electrical connection.

Abstract: A process for making high specific viscosity copolymers of maleic anhydride and an alkyl vinyl either having as specific viscosity of at least 7, preferably 10-50, are made by copolymerizing maleic anhydride and an alkly vinyl ether monomers in the presence of added acetylene.

Abstract: A process for producing polymers having at least one high vinyl end segment is provided. The process comprises: (a) forming a living prepolymer high vinyl initiator with a vinyl content greater than about 45% using a vinyl modifier, (b) adding a R1R2R3aluminum or R1R2R3boron compound to nullify the effect of the vinyl modifier, and (c) initiating polymerization of diene monomers using said living prepolymer high vinyl initiator so as to form a polymer product with at least one high vinyl end segment, where R1, R2, and R3 are selected from the group consisting of C1-C12 alkyl, C2-C12 alkene, C2-C12 alkyne, phenyl, and alkyl-substituted phenyl, and may all be identical or may all be separately selected but cannot be H. The polymers having at least one high vinyl end segment may be coupled to produce a polymer having a high vinyl end segment on all ends.

Abstract: Provided is a catalyst system for producing a polyolefin blend, which catalyst system comprises a mixture including the following catalyst components: i) a catalyst component A capable of producing an isotactic olefin polymer, and/or a catalyst component A? capable of producing a polymer comprising an isotactic polyolefin block; and ii) a catalyst component B capable of producing a syndiotactic polyolefin, and/or a catalyst component B? capable of producing a polymer comprising a syndiotactic polyolefin block; wherein each of the components in the catalyst system is distinct from the other components in the catalyst system.

Abstract: A method for preparing a diene elastomer, such as a butadiene homopolymer or copolymer, in particular, a polybutadiene, with a high level of cis-1,4 linkages that has both a Mooney viscosity greater than or equal to 40 and a polydispersity index of less than 2.1. The method comprises a reaction of a catalyst system with at least one conjugated diene monomer to be polymerized and the catalyst system is based on at least: optionally one preforming conjugated diene; one salt of one or more rare earth metals; an inert hydrocarbon-based solvent; an alkylating agent comprising an allyl derivative of aluminum of formula R?nAlR?3-n, where R? is a saturated or unsaturated alkyl group or else a hydride, where R? is an allyl group and where n is an integer inclusively between 1 and 3; and a halogen donor that belongs to the family of alkylaluminum halides, excluding alkylaluminum sesquihalides.