Abstract: Processes for inhibiting apoptotic cell death and glycosaminoglycan release from injured cartilage is provided. Inhibition is accomplished using caspase inhibitors.

Abstract: The present invention relates to oxygenated esters of 4-iodophenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof. The present invention also relates to crystalline forms of oxygenated esters of 4-iodophenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.

Abstract: Certain lipophilic polycationic sulfonamides are provided and are useful for treating various diseases or conditions and particularly sepsis.

Abstract: The present invention relates to a compound of Antrodia camphorata used to inhibit HBV, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone which is isolated from Antrodia camphorata, and its use in inhibiting HBV effectively. The cyclohexenone compound according to the present invention showed cytotoxicity on HBV-secreting human hepatoma cell line HepG2 2.2.15, decreased synthesis of HBV particles, further inhibited synthesis of HbsAg and HbeAg effectively to achieve the goal of HBV inhibition.

Abstract: Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease.

Abstract: The invention provides A composition for increasing milk production in an animal that includes an active compound chosen from calcium isopropyl cresol, calcium isopropyl-o-cresol, lactic acid, or combinations thereof, and calcium carbonate as a buffering agent. The invention also provides a composition for increasing milk production in an animal that includes about 0.1 wt % to about 15 wt % of the total weight of the composition of active compound, wherein the active compound is chosen from calcium isopropyl cresol, calcium isopropyl-o-cresol, and lactic acid, about 40 wt % to about 75 wt % of the total weight of the composition of calcium carbonate, and about 10 wt % to about 60 wt % of the total weight of the composition of at least one carrier.

Abstract: The blood collection, processing and transfer by separation of discrete components containing additional citrate (at least about trisodium citrate 9% w/v) in one or other of collection or processing bag provides for enhanced yield and purity of cryoprecipitate. Inhibiting the activation or denaturation of blood components including blood cells and plasma proteins and with the removal of the activated and denatured components thereby improving safety and efficacy of end products. The inventive process is particularly suited to an improved extraction process to yield concentrated clotting factors from single donors or limited pools without use of chromatography. Following extraction the remaining cryoprecipitate can advantageously be formed into a fibrin fabric used in surgeries and in the treatment of wounds.

Abstract: A composition comprising the reaction products of MaMHbMEcDdDHeDEfTgTHhTEiQj where M=R1R2R3SiO1/2; MH=R4R5HSiO1/2; ME=R6R7RESiO1/2; D=R8R9SiO2/2; DH=R10HSiO2/2; DE=R11RESiO2/2; T=R12SiO3/2; TH=HSiO3/2; TE=RESiO3/2; and Q=SiO4/2; where R1, R2, R3, R8, R9 and R12 are independently monovalent hydrocarbon radicals having from one to sixty carbon atoms; R4, R5 and R10 are independently monovalent hydrocarbon radicals having from one to sixty carbon atoms or hydrogen; R6, R7, R11 are independently monovalent hydrocarbon radicals having from one to sixty carbon atoms or RE; each RE is independently a monovalent hydrocarbon radical containing one or more oxirane moieties having from one to sixty carbon atoms; the stoichiometric subscripts a, b, c, d, e, f, g, h, i, and j are either zero or positive subject to the following limitations: a+b+c>1; b+e+h>1; c+f+i>1; b+e+h>c+f+i. In a preferred embodiment the reaction product of the present invention is a polyether siloxane copolymer network.

Abstract: The present invention provides a chemical ink comprises a solvent, a binder polymer, a colorant and optionally a crosslinker. The ink of the invention has one or more of the following characteristics: a viscosity lower than about 50 centipoises; a surface tension of from about 20 mN/m to about 60 mN/m; a particle size of less than about 5 ?m; prolonged stability; an appropriate color level (visible by eye); uniform drop formation; jet stability; good adhesion to contact lenses; good transfer from a mold to a lens made in the mold; and stability of ink in inkjet nozzles. The ink of the invention is useful for inkjet printing of a high-quality color image on a contact lens or a mold so as to produce a colored contact lens.

Abstract: The present invention relates to new cure accelerators for anaerobic curable compositions. These anaerobic cure accelerators are generally sulfonimide derivatives and sulfonamide derivatives.

Abstract: Disclosed are compositions for anchoring materials in or to concrete or masonry. The compositions preferably comprise alkylacrylate ester monomer and a copolymer of alkylacrylate ester and methacrylic acid monomers, and free-radical catalyst.

Abstract: Compositions, systems, and methods for protecting an ink-jet produced image printed on a substrate are provided. The composition can comprise a liquid vehicle and latex particulates dispersed in the liquid vehicle, wherein the latex particulates have a surface dielectric constant from 2.0 to 3.0 at room temperature, and a bulk density from 0.1 g/cm3 less to 0.1 g/cm3 greater than the vehicle density. An alternative composition can comprise a liquid vehicle and latex particulates dispersed in the liquid vehicle, wherein the latex particulates have a reactive surfactant covalently attached thereto.

Abstract: A stable, plasticized composition of PVC polymer including a C4-C30 linear, branched or cyclo-alkyl pyrrolidone present in an amount of 5-400 phr sufficient to plasticize said PVC into a flexible state.

Abstract: A flame-retardant resin composition comprises a base resin (A), an organic phosphorus compound (B) having a unit represented by the following formula (1a), and a flame-retardant auxiliary (C). Wherein Ar represents an aromatic hydrocarbon ring or a nitrogen-containing aromatic heterocycle; X1 represents an oxygen atom or a sulfur atom; Y1 and Y2 are the same or different and each represents a hydrocarbon group, an alkoxy group, an aryloxy group, or an aralkyloxy group; Z1 represents an alkylene group, or a nitrogen-containing bivalent group corresponding to an alkylamine; Y1 and Y2 may bind to each other, and Y1 and Y2 together with the adjacent phosphorus atom may form a ring; “a” denotes 0 or 1; and “b” denotes an integer of 1 to 6.

Abstract: A composition comprising a phosphorus containing stabilizer and a polyetherimide sulfone resin having an amount of anhydride functional end groups in excess of the amount of amine functional end groups. The composition may optionally comprise a hindered phenol.

Abstract: The present invention discloses a process for hydrogenating a latex of a low molecular weight functionalized, unsaturated elastomer to produce a latex of a hydrogenated, low molecular weight, low gel, functionalized elastomer, said process comprising hydrogenating the low molecular weight, functionalized, unsaturated elastomer in the presence of (1) an oxidant selected from the group consisting of oxygen and hydroperoxides, (2) a reducing agent selected from the group consisting of hydrazine and hydrazine hydrates, and (3) a metal ion activator, wherein a hydroxylamine is added to the latex of the low molecular weight, functionalized, unsaturated elastomer or to the latex of the hydrogenated, low molecular weight, functionalized elastomer prior, during, or subsequent to the hydrogenation to produce the latex of the hydrogenated low molecular weight, low gel, functionalized elastomer.

Abstract: A rubber composition for a tire tread, in which wet grip performance and dry grip performance can be improved without lowering the rolling resistance property, the rubber composition including 5 to 150 parts by weight of silica having 3 to 100 of an average aspect ratio L1/D between branched particles A-A containing branched particles A on the basis of 100 parts by weight of a rubber component containing a diene rubber, the branched particle A being a particle having contact with at least 3 other particles.

Abstract: A thermoplastic elastomer excellent in rubber elasticity and extrudability and a molded object thereof. The thermoplastic elastomer comprises a partly or wholly crosslinked rubber (A), an isotactic polypropylene (B) having an isotactic pentad content of 0.8 or higher, a syndiotactic polypropylene (C) having a syndiotactic pentad content of 0.6 or higher, and a softener (D), the content of the syndiotactic of the syndiotactic polypropylene (C) being in the range of 0.5 to 10 wt. % based on the sum of the crosslinked rubber (A), isotactic polypropylene (B), syndiotactic polypropylene (C), and softener (D), the thermoplastic elastomer having a melt flow rate of 0.01 to 1000 g/10 min as measured in accordance with ASTMD 1238 at 230° C. under a load of 10 kg. The molded object is obtained by extrusion-molding the elastomer.

Abstract: The invention relates to a sulfur-vulcanizable rubber compound, in particular for treads of tires, which contains at least one diene rubber, liquid polybutadiene with a molecular weight of 1500-10000 g/mol and a vinyl content of 15-50%, at least one polar filler, at least one high-structure black with an iodine adsorption number of 115-200 g/kg and a DBP number of 125-160 mL/100 g and at least one glyceride and/or one factice for good abrasion characteristics, good wet traction and good traction on ice and snow with good dry braking at the same time.

Abstract: The present invention relates to polymer composite materials containing carbon nanotubes, particularly to those containing singled-walled nanotubes. The invention provides a polymer composite comprising one or more base polymers, one or more functionalized m-phenylenevinylene-2,5-disubstituted-p-phenylenevinylene polymers and carbon nanotubes. The invention also relates to functionalized m-phenylenevinylene-2,5-disubstituted-p-phenylenevinylene polymers, particularly to m-phenylenevinylene-2,5-disubstituted-p-phenylenevinylene polymers having side chain functionalization, and more particularly to m-phenylenevinylene-2,5-disubstituted-p-phenylenevinylene polymers having olefin side chains and alkyl epoxy side chains. The invention further relates to methods of making polymer composites comprising carbon nanotubes.

Abstract: In one aspect, the invention provides a water-based release coating composition comprising a mixture of: A. from 0.1 to about 5 wt % of a fluoro(meth)acrylate (co)polymer or a fluorochemical urethane compound containing at least one fluorinated group having the formula —CF2)nCF3, wherein n is an integer from 1 to 3; B. from about 5 to about 99.9 wt % of a copolymer comprising the reaction product of a. from about 40 to about 70 wt % of an alkyl (meth)acrylate, wherein the alkyl group contains from 16 to 22 carbon atoms, b. from about 3 to about 20 wt % of (meth)acrylic acid, c. from about 20 to about 40 wt % acrylonitrile, and d. from 0 to about 15 wt % of vinyl monomer, other than acrylonitrile, wherein the sum of a. through d. equals 100%; and C. from 0 to about 94.9 wt % of an extender polymer, wherein the sum of A., B., and C. is 100% and wt % is based on the total amount of solids in the composition.

Abstract: A clear thermoplastic blend comprises from about 25 to about 90 percent by weight of low flow polycarbonate resin having a MVR (Melt Viscosity Rate) of from about 1 to about 7 cc/10 min at 300° C./1.2 kg and from about 10 to about 75 percent by weight of a polyester resin derived from the condensation of a cyclohexanedimethanol or equivalent thereof alone or with an ethylene glycol or equivalent thereof with a terephthalic acid or equivalents thereof or a combination of terephthalic acid and isophthalic acid or equivalents thereof.

Abstract: A method is provided for making a reinforced polymer electrolyte membrane, such as may be used in electrolytic cells such as fuel cells, by mixing a sulfonate- or sulfonyl halide-functional polymer with a bisamidine compound and subsequently trimerizing the amidine groups of the bisamidine compound to form triazine linkages. The sulfonyl halide or sulfonate groups may then be converted to sulfonic acid groups, yielding a polymer electrolyte reinforced with a polytriazine.

Abstract: A polymer pipe for hot fluids, usually hot water is described. The pipe is characterised in that it comprises a multimodal polyethylene with a high molecular weight (HMW) fraction and a low molecular weight (LMW) fraction where said HMW fraction has a density of at least 0.920 g/cm3, and that the multimodal polyethylene has a density of 0.921-0.950 g/cm3 and has a time to failure at 95° C. and 3.6 MPa of at least 165 h determined according to DIN 16 833 and a modulus of elasticity of at most 900 MPa determined according to ISO 527-2/1B. Preferably, the multimodal polyethylene is a bimodal polyethylene, the LMW fraction having a density of 0.955-0.975 g/cm3, the HMW fraction having a density of 0.920-0.940 g/cm3, and the weight ratio of the LMW fraction to the HMW fraction being from 30:70 to 55:45.

Abstract: Interpolymer resin particles comprised of 20% to 60% by weight of uncross-linked polyolefin e.g. polyethylene, polypropylene, and from 40% to 80% by weight based on the weight of the particles of a vinyl aromatic monomer, e.g. styrene, that is polymerized in a suspension process to form an interpenetrating network of polyolefin with polymerized vinyl aromatic monomer particles and having a gel content of 0 to 1.5% by weight based on the weight of the particles for improved processability in end-use applications and improved ESCR properties. The interpolymer resin particles have a VICAT softening temperature from about 90° C. to about 115° C., and a melt index from 0.2 to 35.0 g/10 minutes (Condition G). The particles can be mixed with a blowing agent to form extruded foam articles, such as foam board, and can be used in extrusion, injection molding, rotomolding, and thermoforming processes to form a layer, e.g.

Abstract: The present invention relates to phenylgycines and derivatives thereof, 1,4-aminobenzoyl compounds, and phenyl pyrazolinones as cure accelerators for anaerobically curable compositions.

Abstract: Polymers comprising units derived from ethylene, said polymer having: a) a Melt Index of from 0.05 to 20 g/10 min. as determined by ASTM-1238 Condition E; b) at least 10 per 1000 C-atoms of short chain branches, containing five carbon atoms or less, as determined by C13 NMR, and less than 3.5 mol %, of units derived from a copolymerizable ethylenically unsaturated ester; c) a density of from 0.90 to 0.94 g/cm3, preferably 0.91 to 0.935 g/cm3, especially 0.92 to 0.93 g/cm3 as determined by ASTM D1505; and d) a relaxation time as described herein of at least 10 s. Such polymers can be obtained by free radical polymerization using a chain transfer agent that incorporates into the polymer chain such as an alpha-olefin, preferably propylene, as a chain transfer agent, preferably in a tubular reactor under circumstances to favor LCB formation in a down stream part of the tubular reactor.

Abstract: A modified diene-?-olefin copolymer which is represented by the formula (1) below and has H2C?C(R5)—COO— in at least a part of the ends. wherein R1 and R2 independently represent a hydroxyl group or H2C?C(R5)—COO—, R3s, R5s, and R6s are independently represent a hydrogen atom or an alkyl group having 1 to 10 carbon atoms, R4s independently represent a phenyl group, a pyridyl group, a chlorine atom, a cyclohexyl group, or a carbonyloxyalkyl group, and l, m, and n represent the number of repetition.

Abstract: The invention provides a method for preparing functionalized polyorganosiloxane resins (POS) comprising units M: (R3SiO1/2), Q: (SiO4/2) and M?: (YaR3-aSiO1/2) and optionally D: (R2SiO2/2) and/or D?: (RYSiO2/2) and T: (RSiO3/2) and/or T?: (YSiO3/2), wherein in said units R is C1-C10, alkyl or C8-C12, aryl and Y is a functional group (such as Si—H), by redistributing POS resins, using POSf bearing functional groups M? and/or D? and/or in the presence of an acid catalyst such as triflic acid or one of its derivatives and a non-basic inert filler: carbon black, diatomaceous earth, zeolite or acid or neutral oxide (Al2O3, Na2O, TiO2, MgO, silica). The invention also provides said catalyst system.

Abstract: Provided are a novel class of fumaric- and itaconic-containing prepolymers and compositions comprising the prepolymers used in the manufacture of medical devices.

Abstract: A linear polymer comprising carborane, siloxane, and acetylene units, which may be cross-linked to a cured polymer and/or pyrolyzed to a ceramic.

Abstract: The present invention provides a method for forming compounds of Formula HO—C(?O)R1—X—R2—X—R1—C(?O)—O—H wherein compound (I) can be polymerized to provide a polymer that contains therapeutically active compounds. In the compounds of the invention, each R1 is group that will provide the therapeutically active compound upon hydrolysis of the polymer; each X is independently an ester linkage or an amide linkage; and R2 is a linking group.

Abstract: A method for making polyetherimides is provided by reacting a high purity dianhydride with an aromatic diamine under condensation polymerization conditions. The dianhydrides employed are purified by a method comprising contacting a first solution containing a dianhydride compound, a solvent, and a phase transfer catalyst, with a solid inorganic adsorbent material having a total pore volume of about 0.5 milliliters/gram or greater and a cumulative pore volume distribution of about 20 percent or greater of particles having a pore diameter in a range between about 3 nanometers and about 20 nanometers. The solution containing the dianhydride compound is then separated from the solid inorganic adsorbent material to provide a purified dianhydride compound which is substantially free of the phase transfer catalyst. The purified dianhydrides are then condensed with aromatic diamines to provide polyetherimide compositions which are substantially free of residual phase transfer catalyst.

Abstract: Disclosed are vinyl ethers and related compositions. The vinyl ethers are the conjugate addition reaction product of reactants comprising a vinyl ether group-containing acrylic ester and a nucleophile.

Abstract: Provided are methods of preparing sulfide-containing polythiol including (a) introducing asym-dichloroacetone together with a polymercaptan to form a reaction product; and (b) introducing the reaction product of (a) with a material chosen from polymercaptoalkylsulfide, polymercaptan and mixtures thereof.

Abstract: An acrylated resin prepared by mixing a hydroxyalkyl acrylate and an isocyanate and reacting said mixture with a resin containing one or more hydroxyl functional groups and derived from a natural product.

Abstract: An ink formulation comprising an acrylated resin prepared by mixing a hydroxyalkyl acrylate and an isocyanate and reacting said mixture with a resin containing one or more hydroxyl functional groups and derived from a natural product.

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Abstract: An artificial red blood cells are disclosed comprising a thin film encapsulating a core, the core comprising hemoglobin, wherein the film comprises a plurality of layers of polypeptides, opposing layers comprising alternating oppositely charged polypeptides, and wherein at least half of the amino acid residues in the oppositely charged polypeptides have the same charge. In one embodiment, a first layer comprises a first layer polypeptide comprising one or more first amino acid sequence motifs, wherein the one or more amino acid sequence motifs consist of n amino acids, at least x of which are positively charged, or at least x of which are negatively charged, wherein x is greater than or equal to approximately one-half of n.

Abstract: The present invention relates to novel human glucagon-like peptide-2 (GLP-2) peptides and human glucagon-like peptide-2 derivatives which have a protracted profile of action as well as polynucleotide constructs encoding such peptides, vectors and host cells comprising and expressing the polynucleotide, pharmaceutical compositions, uses and methods of treatment.

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Abstract: Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.

Abstract: The invention describes SAGE (sdph3.10) and sdp3.5 tumor associated nucleic acids, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such nucleic acid molecules, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a sdph3.10 and/or sdp3.5 gene product.

Abstract: The invention provides isolated nucleic acid and amino acid sequences of Slo2 and Slo4, members of the Slo family of potassium channel proteins, also known as “maxi” or BK potassium channel proteins. Also provided herein are antibodies to Slo2 and Slo 4, methods of detecting Slo2 and Slo 4, methods of screening for potassium channel activators and inhibitors using biologically active Slo2 and Slo 4, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising Slo2 and Slo 4.

Abstract: A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer to tetramer and removing tetramer from the hemoglobin solution.

Abstract: Disclosed herein are antitumor compositions and methods of interfering with the biological activity of PC cell derived growth factor (PCDGF), anti-PCDGF receptor antibodies, fragments thereof, and methods of making anti-PCDGF receptor antibodies. The methods involve inhibiting the proliferation of tumor cells expressing the PCDGF receptor by contacting the surface of the cell with anti-PCDGF receptor antibodies. Anti-PCDGF receptor antibodies are capable of binding to the surface of a cell and interfering with the binding of PCDGF to its receptor. Also provided are compositions comprising anti-PCDGF receptor antibodies and cytotoxic molecules (e.g., toxins, oncotoxins, mitotoxins, immunotoxins, and antisense oligonucleotides).

Abstract: The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Abstract: The present invention concerns methods and kits for diagnosing a disease condition characterized by non-physiological levels of hepcidin, comprising obtaining a tissue or fluid sample from a subject; contacting the sample with an antibody or fragment thereof that specifically binds to a polypeptide corresponding to the mid-portion or C terminus of a hepcidin protein, and quantifying the hepcidin level using an assay based on binding of the antibody and the polypeptide; wherein the non-physiological level of hepcidin is indicative of the disease condition. The present invention also concerns diagnostic methods and kits for applications in genetic technological approaches, such as for overexpressing or downregulating hepcidin. The present invention further concerns therapeutic treatment of certain diseases by treatment of subjects with hepcidin and agonists or antagonists of hepcidin.

Abstract: Monoclonal antibodies to Prox1 of vertebrates (pfam05044.5; NM_002763.3) and two continuous cell lines for their production are disclosed. These antibodies are particularly useful in immunoassays to detect the presence of Prox1 protein in vertebrate tissues and cells.