Patents Issued in July 15, 2014
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Patent number: 8778590Abstract: A lithographic printing plate precursor comprising a coating provided on a support having a hydrophilic surface, the coating containing thermoplastic polymer particles and an IR-dye characterized in that the IR-dye contains a structural element according to Formula I wherein A represents hydrogen, halogen or a monovalent organic group; Y and Y? independently represent —CH— or —N—; R1 and R2 independently represent hydrogen, an optionally substituted alkyl or aryl group or represent the necessary atoms to form a ring; * represents the linking positions to the rest of the molecule.Type: GrantFiled: December 3, 2009Date of Patent: July 15, 2014Assignee: Agfa Graphics NVInventor: Paul Callant
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Patent number: 8778591Abstract: An aralkylcarbamate of imidazole base is effective as the quencher. In a chemically amplified positive resist composition comprising the carbamate, deprotection reaction of carbamate takes place by reacting with the acid generated upon exposure to high-energy radiation, whereby the composition changes its basicity before and after exposure, resulting in a pattern profile with advantages including high resolution, rectangular shape, and minimized dark-bright difference.Type: GrantFiled: August 25, 2011Date of Patent: July 15, 2014Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Masayoshi Sagehashi, Takeru Watanabe, Tomohiro Kobayashi
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Patent number: 8778592Abstract: A positive resist composition based on a polymer comprising recurring units of (meth)acrylate having a cyclic acid labile group and a dihydroxynaphthalene novolak resin, and containing a photoacid generator is improved in resolution, step coverage and adhesion on a highly reflective stepped substrate, has high resolution, and forms a pattern of good profile and minimal edge roughness through exposure and development.Type: GrantFiled: February 24, 2012Date of Patent: July 15, 2014Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Jun Hatakeyama, Takeshi Nagata, Taku Morisawa
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Patent number: 8778593Abstract: A chemical amplification resist composition contains: (A) a polymer compound having a phenolic hydroxyl group and a group formed by substituting a substituent for a hydrogen atom of a hydroxyl group in a phenolic hydroxyl group and satisfying the following (a) to (c) at the same time: (a) the polydispersity is 1.2 or less, (b) the weight average molecular weight is from 2,000 to 6,500, and (c) the glass transition temperature (Tg) is 140° C. or more.Type: GrantFiled: June 29, 2012Date of Patent: July 15, 2014Assignee: FUJIFILM CorporationInventors: Tomotaka Tsuchimura, Tadateru Yatsuo
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Patent number: 8778594Abstract: A resist composition having a resin having a structural unit represented by the formula (I), a resin being insoluble or poorly soluble in alkali aqueous solution, but becoming soluble in an alkali aqueous solution by the action of an acid and not including the structural unit represented by the formula (I), an acid generator, and a compound represented by the formula (II), wherein R1, A1, A13, A14, X12, R23, R24, R25, R26, X21 and X22 are defined in the specification.Type: GrantFiled: July 18, 2012Date of Patent: July 15, 2014Assignee: Sumitomo Chemical Company, LimitedInventors: Koji Ichikawa, Hiromu Sakamoto, Yuichi Mukai
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Patent number: 8778595Abstract: A resist composition containing a base component (A) which generates acid upon exposure, and exhibits changed solubility in a developing solution under the action of acid, wherein the base component (A) contains a polymeric compound (A1) having a structural unit (a5) represented by general formula (a5-0) shown below and a structural unit (a6) that generates acid upon exposure. In the formula, R represents a hydrogen atom, an alkyl group of 1 to 5 carbon atoms or a halogenated alkyl group of 1 to 5 carbon atoms, R1 represents a sulfur atom or an oxygen atom, R2 represents a single bond or a divalent linking group, and Y represents a hydrocarbon group in which a carbon atom or a hydrogen atom may be substituted with a substituent.Type: GrantFiled: November 16, 2012Date of Patent: July 15, 2014Assignee: Tokyo Ohka Kogyo Co., Ltd.Inventors: Daichi Takaki, Daiju Shiono, Yoshiyuki Utsumi, Jun Iwashita
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Patent number: 8778596Abstract: A photosensitive resin composition which is excellent in resolution, low in cost, and usable in a wide range of structures of polymer precursors each of which is reacted into a final product by a basic substance or by heating in the presence of a basic substance. The photosensitive resin composition includes a base generator which has a specific structure and generates a base by exposure to electromagnetic radiation and heating, and a polymer precursor which is reacted into a final product by the base generator and by a basic substance or by heating in the presence of a basic substance.Type: GrantFiled: April 25, 2013Date of Patent: July 15, 2014Assignee: Dai Nippon Printing Co., Ltd.Inventors: Mami Katayama, Shunji Fukuda, Katsuya Sakayori
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Patent number: 8778597Abstract: A curable composition that maintains good handleability in the liquid form and that can be photo- or heat-cured to form a cured product having physical properties including both high transparency and high flexural strength. A curable composition includes, an epoxy compound of (1): [where each of E1, E2, and E3 is independently an organic group of Formula (2) or Formula (3); and each of R1, R2, and R3 is independently an optionally branched alkylene group or oxyalkylene group: (where R4 is a hydrogen atom or a methyl group)]; and an acid generator.Type: GrantFiled: January 24, 2011Date of Patent: July 15, 2014Assignee: Nissan Chemical Industries, Ltd.Inventors: Toshiaki Takeyama, Yuki Endo, Takeo Moro, Kentaro Ohmori
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Patent number: 8778598Abstract: A method of forming fine patterns of a semiconductor device according to a double patterning process that uses acid diffusion is provided. In this method, a plurality of first mask patterns are formed on a substrate. A capping film including an acid source is formed on the exposed surface areas of the plurality of first mask patterns. A second mask layer is formed on the capping films. A plurality of acid diffused regions are formed within the second mask layer by diffusing acid obtained from the acid source from the capping films into the second mask layer. A plurality of second mask patterns are formed of residual parts of the second mask layer which remain after removing the acid diffused regions of the second mask layer.Type: GrantFiled: December 12, 2012Date of Patent: July 15, 2014Assignee: Samsung Electronics Co., Ltd.Inventors: Yool Kang, Suk-joo Lee, Jung-hyeon Lee, Shi-yong Yi
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Patent number: 8778599Abstract: Provided is a method of producing an ink ejection head including a substrate, an ink ejection energy-generating element, a flow path-forming member, and an ejection orifice-forming member having an ink ejection orifice, the ink ejection orifice having, on a side open to an outside, a portion whose sectional area is constant and a portion whose sectional area increases from the portion to an ink ejection energy-generating element side, the method including: forming, on the substrate, a first negative photosensitive resist; forming, on the first negative photosensitive resist, a second negative photosensitive resist; partially mixing the first negative photosensitive resist and the second negative photosensitive resist to form a compatible layer; and subjecting the second negative photosensitive resist and the compatible layer to collective exposure and development to form the ink ejection orifice.Type: GrantFiled: October 30, 2013Date of Patent: July 15, 2014Assignee: Canon Kabushiki KaishaInventors: Kunihito Uohashi, Kazuhiro Asai, Keiji Matsumoto
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Patent number: 8778600Abstract: A method of forming a high resolution organic thin film pattern, the method including forming a first organic layer on a substrate; selectively removing the first organic layer by selectively irradiating light energy onto the first organic layer, and forming a remaining part of the first organic layer as a sacrifice layer; forming a second organic layer on the substrate and the entire surface of the sacrifice layer; and lifting off the second organic layer formed on the sacrifice layer by removing the sacrifice layer using a solvent, and forming the remaining second organic layer as a second organic layer pattern.Type: GrantFiled: December 27, 2010Date of Patent: July 15, 2014Assignees: Samsung Display Co., Ltd., SNU R&DB FoundationInventors: Min-Chul Suh, Sin-Doo Lee, Won-Suk Choi, Min-Hoi Kim
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Patent number: 8778601Abstract: Provided are methods of forming photolithographic patterns using a negative tone development process. Also provided are coated substrates and electronic devices formed by the methods. The methods find particular applicability in the manufacture of electronic devices.Type: GrantFiled: March 7, 2011Date of Patent: July 15, 2014Assignee: Rohm and Haas Electronic MaterialsInventors: Seokho Kang, Charlotte Cutler
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Patent number: 8778602Abstract: A method of lithography patterning includes coating a resist layer on a substrate; performing an exposing process to the resist layer using a lithography tool with a numerical aperture tuned between about 0.5 and about 0.6; baking the resist layer; thereafter performing a first developing process to the resist layer for a first period of time; and performing a second developing process to the resist layer for a second period of time.Type: GrantFiled: September 18, 2009Date of Patent: July 15, 2014Assignee: Taiwan Semiconductor Manufacturing Company, Ltd.Inventors: Hung-Ting Pan, Jing-Huan Chen, Wei-Chung Ma, Hsin-Chun Chiang, Po-Chung Cheng, Szu-An Wu
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Patent number: 8778603Abstract: A method of treating resist features comprises positioning, in a process chamber, a substrate having a set of patterned resist features on a first side of the substrate and generating a plasma in the process chamber having a plasma sheath adjacent to the first side of the substrate. The method may further comprise modifying a shape of a boundary between the plasma and the plasma sheath with a plasma sheath modifier so that a portion of the shape of the boundary is not parallel to a plane defined by a front surface of the substrate facing the plasma, wherein ions from the plasma impinge on the patterned resist features over a wide angular range during a first exposure.Type: GrantFiled: March 11, 2011Date of Patent: July 15, 2014Assignee: Varian Semiconductor Equipment Associates, Inc.Inventors: Ludovic Godet, Patrick M. Martin, Timothy J. Miller, Vikram Singh
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Patent number: 8778604Abstract: A mask set for double exposure process and method of using said mask set. The mask set is provided with a first mask pattern having a first base and a plurality of first teeth and protruding portions, and a second mask pattern having a second base and a plurality of second teeth, wherein the second base may at least partially overlap the first base such that each of the protruding portions at least partially overlaps one of the second teeth.Type: GrantFiled: April 24, 2012Date of Patent: July 15, 2014Assignee: United Microelectronics Corp.Inventors: Hui-Fang Kuo, Ming-Jui Chen, Ting-Cheng Tseng, Cheng-Te Wang
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Patent number: 8778605Abstract: Described herein is mask design and modeling for a set of masks to be successively imaged to print a composite pattern on a substrate, such as a semiconductor wafer. Further described herein is a method of double patterning a substrate with the set of masks. Also described herein is a method of correcting a drawn pattern of one of the mask levels based on a predicted pattern contour of the other of the mask levels. Also described herein is a method of modeling a resist profile contour for a mask level in which photoresist is applied onto a inhomogeneous substrate, as well as method of predicting a resist profile of a Boolean operation of two masks.Type: GrantFiled: February 7, 2013Date of Patent: July 15, 2014Assignee: Intel CorporationInventors: Shem Ogadhoh, Raguraman Venkatesan, Kevin J. Hooker, Sungwon Kim, Bin Hu, Vivek Singh, Bikram Baidya, Prasad Narendra Atkar, Seongtae Jeong
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Patent number: 8778606Abstract: The at home cancer test permits a layperson to qualitatively test for the presence of carcinoma in the privacy of their home. The test includes a test strip coated or impregnated with at least one monoclonal antibody that binds to ?-hCG/CGH found in the patient's urine, together with a chromophore that provides a color indicator when such binding takes place. The at-home cancer test may comprise a kit containing one or more of the following: a test strip with a tab that can be gripped by the user while the strip is placed in a stream of urine; a cup for collecting urine and a test strip that may be partially immersed in the cup; and a cup for collecting urine, a test strip, and a medicine dropper or pipette for transferring the urine to the test strip.Type: GrantFiled: July 27, 2006Date of Patent: July 15, 2014Inventor: John A. Swetledge
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Patent number: 8778607Abstract: A method of conducting in vitro toxicity testing is disclosed which includes the steps of exposing to a test agent a population of human liver progenitor or stem cells originated from human adult liver. The cells have the characteristics that the isolated human progenitor or stem cells express at least the mesenchymal markers vimentin and ?-smooth muscle actin (ASMA), the hepatocyte marker albumin (ALB), are negative for cytokeratin-19 (CK-19), and have mesenchymal-like morphology. One or more effects, if any, of the test agent on the population of human liver progenitor or stem cells are observed. Also disclosed are methods of conducting in vitro drug metabolism studies by exposing to a test agent a population of the human liver progenitor or stem cells and methods of testing infected human liver progenitor or stem cells for effects of a test agent.Type: GrantFiled: January 10, 2014Date of Patent: July 15, 2014Assignee: Universite Catholique de LouvainInventors: Etienne Sokal, Mustapha Najimi
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Patent number: 8778608Abstract: Methods and compositions for providing a prognosis or diagnosis for a human patient having renal cell cancer are provided. The method relates to the discovery of SNPs which are associated with a favorable prognosis and response to therapy in RCC.Type: GrantFiled: October 8, 2009Date of Patent: July 15, 2014Assignee: The Regents of the University of CaliforniaInventors: Arie S. Belldegrun, Allan J. Pantuck
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Patent number: 8778609Abstract: The invention generally relates to methods for analyzing nucleic acids. In certain aspects, methods of the invention involve obtaining a sample including a nucleic acid template. A plurality of molecular inversion probes are tiled across a portion of the template. The probes are designed such that immediately adjacent probes hybridize to opposite strands of the nucleic acid template and probes on the same strand hybridize to the template in an overlapping manner. A region between targeting arms of a plurality of the molecular inversion probes is filled-in with nucleotides, and the filled-in region of a plurality of the probes is analyzed to obtain sequence information about the nucleic acid template.Type: GrantFiled: March 14, 2014Date of Patent: July 15, 2014Assignee: Good Start Genetics, Inc.Inventor: Mark Umbarger
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Patent number: 8778610Abstract: The present invention concerns isolation, library preparation and selective amplification from a compositionally heterogeneous pool of DNA fragments of a fraction of molecules, such as those originating from promoter CpG islands and characterized by a high GC content. In particular, the process utilizes a heat-induced segregation of DNA molecules into GC-poor, single-stranded molecule fractions and GC-rich, double-stranded molecule fractions, with subsequent enzymatic conversion of the GC-rich, double-stranded DNA molecules into a library, and, optionally, amplification. In specific embodiments, the isolation process is used to generate promoter-enriched genomic and methylome libraries for research and diagnostic applications, for example.Type: GrantFiled: February 27, 2013Date of Patent: July 15, 2014Assignee: Rubicon Genomics, Inc.Inventors: Vladimir L. Makarov, Emmanuel Kamberov, Brendan J. Tarrier
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Patent number: 8778611Abstract: There is provided a method for detecting M. genitalium nucleic acid in a sample, comprising: (i) amplifying a nucleic acid sequence comprising a fragment of SEQ ID NO: 1 (Mg219 gene); and (ii) detecting said amplified nucleic acid sequence.Type: GrantFiled: May 24, 2007Date of Patent: July 15, 2014Assignee: The Secretary of State for HealthInventors: Vicki Chalker, Cathy Ison
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Patent number: 8778612Abstract: A method for the quantitative assay of n different analytes, where n is at least 2, is provided. The method consists of the following steps: (a) At least one labeled detector-binding partner is added to a test sample containing the analytes. This leads to the formation of detector-analyte complexes, each of which consists of one analyte molecule and one detector molecule. The number of detector binding partners x equals n?1. Each detector-binding partner binds to at least one analyte. At least one of the detector-binding partners can bind to at least two analytes. (b) The detector-analyte complexes formed in step (a) bind to capture-binding partners and form detector-analyte-capture complexes. The number of capture-binding partners y equals the number n of the analytes. Each capture-binding partner is specific for at least one detector-analyte complex. (c) The time-resolved formation of the detector-analyte-capture complexes is measured.Type: GrantFiled: March 7, 2003Date of Patent: July 15, 2014Assignee: PE Diagnostik GmbHInventors: Uwe Kempin, Thomas A. Keller
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Patent number: 8778613Abstract: A resin which is prepared by polymerizing a monomer component incorporating a hydrophilic spacer, and a ligand-immobilized solid phase carrier obtained by immobilizing a ligand to the resin, are capable of reducing the non-specific adsorption of substances, other than the target molecule for the ligand, which mingle in the sample, to the resin and/or the ligand. Therefore, target molecule search, identification and the like with less noise are enabled.Type: GrantFiled: October 15, 2004Date of Patent: July 15, 2014Assignee: Reverse Proteomics Research Institute Co., Ltd.Inventors: Akito Tanaka, Takaaki Shiyama, Akira Yamazaki
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Patent number: 8778614Abstract: Provided are methods and compositions which are useful for separating, isolating, detecting, and quantifying compounds of interest which have been modified chemically, enzymatically or catalytically from other compounds which have not been so modified. The modifications may take the form of functional groups which are gained, lost or retained by the compounds of interest.Type: GrantFiled: August 24, 2010Date of Patent: July 15, 2014Assignee: Enzo Life Sciences, Inc.Inventors: Elazar Rabbani, Joshua Rabbani, Praveen Pande, Jannis G. Stavrianopoulos
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Patent number: 8778615Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury.Type: GrantFiled: October 21, 2009Date of Patent: July 15, 2014Assignee: Astute Medical, Inc.Inventors: Joseph Anderberg, Jeff Gray, Paul McPherson, Kevin Nakamura
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Patent number: 8778616Abstract: The results presented herein demonstrate the specific expression of CCR3 in CNV endothelial cells in humans with AMD, and despite the expression of its ligands, eotaxin-1, -2, and -3, neither eosinophils nor mast cells are present in human CNV. The genetic or pharmacological targeting of CCR3 or eotaxins as disclosed herein inhibited injury-induced CNV in mice. CNV suppression by CCR3 blockade was due to direct inhibition of endothelial cell proliferation, and was uncoupled from inflammation as it occurred in mice lacking eosinophils or mast cells and was independent of macrophage and neutrophil recruitment. CCR3 blockade was more effective at reducing CNV than vascular endothelial growth factor-A (VEGF-A) neutralization, which is currently in clinical use, and, unlike VEGF-A blockade, not toxic to the mouse retina. In vivo imaging with CCR3-targeting quantum dots located spontaneous CNV invisible to standard fluorescein angiography in mice before retinal invasion.Type: GrantFiled: May 26, 2010Date of Patent: July 15, 2014Assignee: University of Kentucky Research FoundationInventors: Jayakrishna Ambati, Mark Ellsworth Kleinman
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Patent number: 8778617Abstract: The invention relates to a method for determining the binding constant of a compound of interest to proteins comprising the following steps: a) adding the high affinity compound to a two-chamber system, wherein the two chambers are separated by a semipermeable membrane, which is permeable for the compound of interest, and determining the amount of the high affinity compound of interest in one of the chambers after the distribution equilibrium has been reached, b) adding a sink compound to one of the chambers whereby the sink compound can not permeate the membrane, and determining the distribution coefficient of the compound of interest to the sink compound after the distribution equilibrium has been reached, c) adding an unspecific protein to the other chamber, whereby the unspecific protein can not permeate the membrane, and determining the distribution coefficient of the compound of interest to the unspecific protein in presence of a sink compound after the distribution equilibrium has been reached, and d)Type: GrantFiled: February 22, 2011Date of Patent: July 15, 2014Assignee: Hoffmann-La Roche Inc.Inventors: Frauke Assmus, Holger Fischer
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Patent number: 8778618Abstract: The invention provides compositions, methods, and kits diagnosing, monitoring, and otherwise characterizing a myopathy and for detecting the presence of autoantibodies in a biological sample.Type: GrantFiled: April 15, 2011Date of Patent: July 15, 2014Assignee: The Johns Hopkins UniversityInventors: Livia Angela Casciola-Rosen, Lisa Christopher-Stine, Andrew Mammen, Antony Rosen
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Patent number: 8778619Abstract: Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, oxidized cardiolipins, which may be conjugated with a variety of attachment molecules, such as BSA, KLH, biotin, synthetic protein MAPS, IgY, streptavidin, or avidin, are described. Such oxidized cardiolipin, alone or complexed with one or more attachment molecules, are useful to detect anti-lipoidal antibodies (such as IgG and IgM antibodies) in subjects, for example, when used in ELISA plates. ELISA plates are described that permit the detection of anti-lipoidal antibodies and that permit the co-detection of nontreponemal and treponemal antibodies in biological samples.Type: GrantFiled: November 13, 2013Date of Patent: July 15, 2014Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, Arlington Scientific Inc.Inventors: Arnold R. Castro, Himanshu Champaklal Mody
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Patent number: 8778620Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.Type: GrantFiled: May 17, 2012Date of Patent: July 15, 2014Assignee: Nodality, Inc.Inventors: Wendy J. Fantl, David B. Rosen, Alessandra Cesano, Santosh K. Putta, Garry Nolan, Aileen Cohen, Erik Evensen
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Patent number: 8778621Abstract: The present invention relates to phosphodiesterase 4D7 (PDE4D7) for use as a marker for malignant, hormone-sensitive prostate cancer, wherein the expression of the marker is increased when comparing the expression in malignant, hormone-sensitive prostate cancer tissue, to the expression in normal tissue or benign prostate tumor tissue, and the use of PDE4D7 as a diagnostic marker for malignant, hormone-sensitive prostate cancer. The present invention also relates to a composition for diagnosing, detecting, monitoring or prognosticating malignant, hormone-sensitive prostate cancer, a corresponding detection method, a method allowing to discriminate between a benign and malignant hormone-sensitive prostate cancer and a method of data acquisition, as well as corresponding immunoassays. The present invention also relates to a method of identifying an individual for eligibility for malignant, hormone-sensitive prostate cancer as well as an immunoassay for stratifying an individual with such prostate cancer.Type: GrantFiled: May 11, 2010Date of Patent: July 15, 2014Assignee: Koninklijke Philips N.V.Inventors: Ralf Hoffmann, Miles Douglas Houslay, David James Peter Henderson
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Patent number: 8778622Abstract: Disclosed herein are methods and kits which are useful for detecting presence of an enzyme in a test sample based upon the intrinsic enzymatic activity of such test sample. The present invention provides the ability to evaluate cell culture conditions and optimize the desired glycoform content of recombinantly prepared enzymes.Type: GrantFiled: November 30, 2010Date of Patent: July 15, 2014Assignee: Shire Human Genetic Therapies, Inc.Inventor: Daniel S. Roseman
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Patent number: 8778623Abstract: Differentiated cholinergic cells having motor neuron-like morphology and increased sensitivity to botulinum neurotoxin are provided herein. Methods of using such differentiated cells for detecting neurotoxin are also provided.Type: GrantFiled: February 28, 2013Date of Patent: July 15, 2014Assignee: Wisconsin Alumni Research FoundationInventors: Eric Arthur Johnson, Regina Whitemarsh, Sabine Pellett
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Patent number: 8778624Abstract: Hydrophilic, chemiluminescent acridinium compounds containing zwitterions are disclosed. These acridinium compounds, when used as chemiluminescent labels in immunochemistry assays and the like, exhibit decreased non-specific binding to solid phases and provide increased assay sensitivity.Type: GrantFiled: November 12, 2010Date of Patent: July 15, 2014Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Anand Natrajan, David Sharpe, Qingping Jiang
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Patent number: 8778625Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.Type: GrantFiled: September 7, 2012Date of Patent: July 15, 2014Assignee: Pharmacyclics, Inc.Inventors: Aleksandr Kolesnikov, Roopa Rai, William Dvorak Shrader, Steven M. Torkelson, Kieron E. Wesson, Wendy B. Young
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Patent number: 8778626Abstract: A clickable cross-linker compound provides an easily scanned reporter ion for effective and efficient cross-linking and identification of intermolecular and intramolecular interactions of proteins and peptides.Type: GrantFiled: July 8, 2011Date of Patent: July 15, 2014Assignee: California Institute of TechnologyInventors: Chang Ho Sohn, Jesse L. Beauchamp
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Patent number: 8778627Abstract: Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.Type: GrantFiled: December 14, 2011Date of Patent: July 15, 2014Assignee: Biotium, Inc.Inventors: Fei Mao, Hui Cen, Wai-Yee Leung
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Patent number: 8778628Abstract: An arylalkylamine compound is represented by the following formula [I-e] or a pharmaceutically acceptable salt thereof.Type: GrantFiled: June 17, 2013Date of Patent: July 15, 2014Assignee: Mitsubishi Tanabe Pharma CorporationInventors: Hiroshi Miyazaki, Junko Okabe, Kosuke Yasuda, Iwao Takamuro, Osamu Sakurai, Tetsuya Yanagida, Yutaka Hisada
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Patent number: 8778629Abstract: A sterility test method includes: selecting strain and culture medium, preparing bacterial cultures, transcribing fingerprint characteristics in thermograms as indices to verify the characteristics, drawing the thermodynamic parameters of the thermogram, determining the positive judgment index and performing sterility test for the samples. A fully-enclosed bacteria collecting ampoule incubator includes bacteria collecting ampoule system, sample and liquid feeding system and peristalsis liquid discharge system. The sample and liquid feeding system is connected with the bacteria collecting ampoule system by the liquid intake tube; and the bacteria collecting ampoule system is connected with the peristalsis liquid discharge system by the liquid drainage tube. The invention is characterized by short inspection time, high sensitivity, high automation and accurate test results on microbial contamination. It can also provide the overall process curve on the growth conditions.Type: GrantFiled: June 28, 2011Date of Patent: July 15, 2014Assignee: 302 Military Hospital of ChinaInventors: Dan Yan, Xiaohe Xiao, Ping Zhang, Yongshen Ren, Cheng Jin
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Patent number: 8778630Abstract: A first permeable mesh membrane may be configured to be tautly stretched over a tissue sample and overlaid over a surface. A first permeable mesh membrane may sandwich and secure a tissue sample in between a first permeable mesh membrane and a surface. A first permeable mesh membrane may have a sieve size of approximately 10 ?m to approximately 100 ?m.Type: GrantFiled: October 6, 2011Date of Patent: July 15, 2014Assignee: George Mason Intellectual Properties, Inc.Inventors: Eswar Prasad Ramachandran Iyer, Daniel N. Cox
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Patent number: 8778631Abstract: This invention provides for a novel means of incorporating non-native amino acids into preselected positions of a protein using a cell-free synthesis system. The methods involve the use of non-orthogonal, native isoaccepting sense tRNAs that are encoded by the genetic code. Such methods allow for numerous non-native amino acids to be incorporated through the use of sense codons without having to rely upon orthogonal tRNA-synthetase pairs.Type: GrantFiled: January 12, 2010Date of Patent: July 15, 2014Assignee: Sutro Biopharma, Inc.Inventors: Alexei M. Voloshin, James F. Zawada, Daniel Gold, Christopher James Murray, James Edward Rozzelle, Nathan Uter, Gang Yin
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Patent number: 8778632Abstract: The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 6 (i.e., “?6-desaturase”). In particular, ?6-desaturase may be utilized, for example, in the conversion of linoleic acid to ?-linolenic acid and in the conversion of ?-linolenic acid stearidonic acid. The polyunsaturated fatty acids produced by use of the enzyme may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.Type: GrantFiled: October 23, 2008Date of Patent: July 15, 2014Assignee: Abbott LaboratoriesInventors: Pradip Mukerji, Yung-Sheng Huang, Amanda E. Leonard, Suzette L. Pereira, Jennifer M. Thurmond
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Patent number: 8778633Abstract: The present invention relates to novel agents that are useful for modulating transcription factor activity. In particular, the present invention relates to a transcription factor modulator comprising (i) a pharmaceutically-effective amount of a HLS-5 polypeptide, isoform thereof, functional fragment thereof or pharmaceutical composition thereof or (ii) a compound or composition capable of regulating the endogenous levels of HLS-5 or its activity; or (iii) combinations thereof.Type: GrantFiled: December 2, 2011Date of Patent: July 15, 2014Assignee: Molecular Discover SystemsInventors: Jean-Philippe Lalonde, Robin Scaife, S. Peter Klinken
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Patent number: 8778634Abstract: The present invention is directed to non-cytotoxic protein conjugates for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell. The protein conjugates comprise: (i) a Targeting Moiety (TM), wherein the TM is an agonist of a receptor present on a nociceptive sensory afferent cell, and wherein the receptor undergoes endocytosis to be incorporated into an endosome within the nociceptive sensory afferent cell; (ii) a non-cytotoxic protease or a fragment thereof, wherein the protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of the nociceptive sensory afferent cell; and (iii) a Translocation Domain, wherein the Translocation Domain translocates the protease or protease fragment from within the endosome, across the endosomal membrane, and into the cytosol of the nociceptive sensory afferent cell wherein the Targeting Moiety is selected from the group consisting of BAM, ?-endorphin, bradykinin, substance P, dynorphin and/or nociceptin.Type: GrantFiled: March 13, 2012Date of Patent: July 15, 2014Assignees: Syntaxin, Ltd., Allergan, Inc.Inventors: Keith Foster, John Chaddock, Charles Penn, Kei Roger Aoki, Joseph Francis, Lance Steward
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Patent number: 8778635Abstract: The present invention relates to functional, modified glucose-galactose binding proteins (GGBPs), that have a greater melting temperature (Tm) than a reference GGBP. The present invention also relates to biological sensors, e.g., glucose sensors, comprising these thermostable GGBPs. The present invention also relates to nucleic acids encoding these thermostable GGBPs.Type: GrantFiled: July 24, 2013Date of Patent: July 15, 2014Assignee: Becton, Dickinson and CompanyInventors: Terry J. Amiss, Erin M. Gill, Douglas Byron Sherman
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Patent number: 8778636Abstract: Processes for preparing pimecrolimus starting from ascomycin, exploiting the selectivity characteristics of the purified enzymatic systems particularly regarding the selective functionalization of the hydroxyl groups present in position 24 and 33 of ascomycin. Such method represents the first example of chemoenzymatic synthesis for preparing pimecrolimus.Type: GrantFiled: May 19, 2010Date of Patent: July 15, 2014Assignee: Euticals S.p.A.Inventors: Paride Grisenti, Shahrzad Reza Elahi, Elisa Verza
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Patent number: 8778637Abstract: The present invention provides a method for performing thermal melt analysis using a microfluidic device, the method comprising providing a microfluidic device having at least one microfluidic channel, introducing fluid comprising into the at least one microfluidic channel, continuously flowing the fluid through the at least one microfluidic channel while varying the temperature of the entire fluid stream as it moves through the at least one microfluidic channel by uniformly heating the entire fluid stream, and measuring, while continuously flowing the fluid through the at least one microfluidic channel, a detectable property emanating from the fluid.Type: GrantFiled: May 5, 2006Date of Patent: July 15, 2014Assignee: Canon U.S. Life Sciences, Inc.Inventors: Ivor T. Knight, Deborah J. Boyles
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Patent number: 8778638Abstract: The present disclosure provides methods for determining phased nucleic acid sequence for a single chromosome of interest and/or a single chromosomal fragment of interest. The present disclosure also provides methods for determining phased nucleic acid sequence for a plurality of single chromosomes of interest and/or a plurality of single chromosomal fragments of interest. The plurality of single chromosomes of interest may be of one or more chromosome types. The present disclosure also provides a method for isolating a plurality of chromosomal fragments of a specified size range, where the chromosomal fragments are from one or more specified regions of the genome. The plurality of chromosomal fragments may be separated into single chromosomal fragments and sequenced to provide phased nucleic acid sequence for the single chromosomal fragments. Alternatively, the plurality of chromosomal fragments may be sequenced together to provide unphased nucleic acid sequence for the chromosomal fragments.Type: GrantFiled: November 15, 2011Date of Patent: July 15, 2014Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Wing H. Wong, Hong Yang
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Patent number: 8778639Abstract: The present invention relates to isolated polypeptides having endoglucanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: GrantFiled: February 12, 2013Date of Patent: July 15, 2014Assignee: Novozymes Inc.Inventor: Nikolaj Spodsberg