Abstract: A process for preparing telmisartan by reacting 2-n-propyl-4-methyl-6-(1?-methylbenzimidazol-2?-yl)benzimidazole with a compound of formula (IV) wherein Z is a leaving group, to obtain the compound 2-cyano-4?-[2?-n-propyl-4?-methyl-6?-(1??-methylbenzimidazol-2??-yl)benzimidazol-1?-ylmethyl]biphenyl, and subsequently hydrolyzing the nitrile function to obtain the acid function.

Abstract: The present invention is directed to benzimidazolone derivatives which are positive allosteric modulators of the mGluR2 receptor, useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved, such as schizophrenia.

Abstract: The present invention relates to novel amide derivatives of N-urea substituted amino acids, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.

Abstract: The invention relates to novel fluorescent compounds derived from non-fluorinated dipyrromethene-boron, to a method for preparing same and to the use thereof for the fluorescent marking of biological molecules. The invention also relates to biological molecules marked with said fluorescent compounds, and to the use thereof in detection methods such as medical diagnosis methods. More particularly, the detection methods of the invention are particularly useful for diagnosing neurodegenerative diseases such as Alzheimer's disease.

Abstract: The invention relates to novel compounds of the formula (I) in which W, X, Y, Z, A and G have the meanings given above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides, and also to selective herbicidal compositions comprising, firstly, the cis-alkoxyspirocyclic biphenyl-substituted tetramic acid derivatives of the formula (I) and, secondly, at least one crop plant compatibility-improving compound. The invention relates furthermore to increasing the activity of crop protection compositions comprising compounds of the formula (I) by adding ammonium or phosphonium salts and, if appropriate, penetrants.

Abstract: A compound for an organic photoelectric device, the compound being represented by the following Chemical Formula 1:

Abstract: The present disclosure relates to new polymethine compounds and their use as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.

Abstract: The present invention relates to pyrrolidin-2-ones according to the formula (1), or salts thereof, wherein R1 is hydrogen or a nitrogen protecting group, methods for their preparation and their use in the preparation of NEP-inhibitors, particularly in the preparation of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.

Abstract: The main object of the present invention relates to a novel crystalline form of Fosemprenavir Calcium designated as Form A. Another object of the present invention relates to a process for the preparation of Crystalline Form A of Fosemprenavir Calcium. Yet another object of the present invention relates to crystalline Forma A of Fosemprenavir Calcium characterized by a PXRD diffraction having reflections at about 3.1±0.2, 4.4±0.2, 5.0±0.2, 6.3±0.2, 7.4±0.2, 8.0±0.2, 2?.

Abstract: The present invention relates to a method for preparing 1,3,5-trioxane using a distillation tower including a reactor, a distillation section, and an extraction section. Particularly, the present invention relates to a method for preparing 1,3,5-trioxane, in which the water phase separated from the stream discharged through the extraction unit of the reaction distillation tower is used in the process of extracting 1,3,5-trioxane.

Abstract: A compound of formula (I), wherein R1 is hydrogen or a hydroxyl protecting group; and R2 and R3 are same or different and are independently selected from halogen or —O—SO2—X; wherein X is —C1-C4 alkyl; C1-C4 alkyl substituted with one or more halogen; or substituted or unsubstituted phenyl wherein said phenyl substituent is selected from halogen, nitro and C1-C4 alkyl; provided that when R3 is bromine, X is not p-toluoyl; and a process for the preparation thereof.

Abstract: The present invention provides a process for preparing methyl 5-acetamido-4-amino-6-(1,2,3-triacetoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylate (V), which process comprises reducing methyl 5-acetamido-4-azido-6-(1,2,3-triacetoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylate (IV) in the presence of a reducing agent selected from the group consisting of lithium aluminum hydride, sodium borohydride, zinc/ammonium chloride, zinc-ferric chloride and ferric chloride/sodium iodide. The present invention also provides compounds of formula (VIII) and (IX) which may be used in the synthesis of zanamivir. The present invention also provides processes for preparing compounds (VIII) and (IX) and processes involving their use, including in the synthesis of zanamivir.

Abstract: Provide is an oxetane-ring containing (meth) acrylic ester compound which can give, through polymerization, a cured article being highly flexible or thermally stable. The oxetane-ring-containing (meth) acrylic ester compound is represented by formula (1) below, in which R1 represents a hydrogen atom or an alkyl group; R2 represent a hydrogen atom or a methyl group; and “A” represent either a linear alkylene group represented by following formula (a1) or a branched-chain alkylene group represented by following formula (a2).

Abstract: To provide an efficient method of producing an epoxy compound comprising reacting hydrogen peroxide and acetonitrile with the carbon-carbon double bond of an organic compound having a carbon-carbon double bond. A method of producing an epoxy compound comprising epoxidizing the carbon-carbon double bond of an organic compound having a carbon-carbon double bond in the presence of acetonitrile by using hydrogen peroxide as an oxidizing agent, wherein the reaction proceeds while controlling the acetonitrile concentration in the reaction system in the range of 0.6-5 mol/L by using a solvent containing an alcohol.

Abstract: The invention relates to polyglycol ether-free, polyglycerol partial ester-based sulphosuccinates, the preparation thereof, and the use of these in cosmetic formulations and also in cleaning compositions in the industrial and domestic sector and formulations comprising these sulphosuccinates.

Abstract: The present invention provides bifunctional silica mesoporous materials, including mesoporous silica nanoparticles (“MSN”), having pores modified with diarylammonium triflate and perfluoroaryl moieties, that are useful for the acid-catalyzed esterification of organic acids with organic alcohols.

Abstract: A method for preparing a polyorganosiloxane, wherein the method includes a step of subjecting at least one organic silicon compound having at least one —OX group bonding to a silicon atom in the molecule, wherein X is a hydrogen atom, an alkyl group having 1 to 10 carbon atoms or an alkoxyalkyl group having 2 to 10 carbon atoms, to a condensation reaction in the presence of a catalyst, wherein the catalyst is one obtained by surface treating at least one selected from the group consisting of hydroxides of elements in Group II of the periodic table, hydrates of hydroxides of elements in Group II of the periodic table and oxides of elements in Group II of the periodic table with a silane coupling agent.

Abstract: Novel improved processes for the production and isolation of methylidene malonates via direct and indirect adduct processes.

Abstract: The present invention relates to a process for the separation of vinyl acetate from a gas mixture formed by the reaction of ethylene with acetic acid and oxygen in the gas phase over catalysts comprising palladium or palladium compounds.

Abstract: The present invention provides crystalline solid and amorphous forms of (?)-halofenate. The crystalline solid forms may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of conditions associated with blood lipid deposition in a mammal, particularly those diseases related to Type 2 diabetes and hyperlipidemia. The invention also relates to a method for preventing or treating Type 2 diabetes and hyperlipidemia in a mammal comprising the step of administering a therapeutically effective amount of crystalline solid and amorphous forms of (?)-halofenate.

Abstract: The present invention is directed to an isomerized alpha olefin sulfonate and a method of making the same wherein the isomerized alpha olefin sulfonate is derived from sulfonating an isomerized alpha olefin with sulfur trioxide in the presence of air thereby producing an isomerized alpha olefin sulfonic acid, wherein the isomerized alpha olefin is derived from the isomerization of C12-C20 normal alpha olefins; and neutralizing the isomerized alpha olefin sulfonic acid with a source of an alkali metal or ammonium or substituted ammonium ion.

Abstract: A method for producing a purified naphthalenedicarboxylic acid includes steps of mixing a naphthalenedicarboxylic acid-containing material and an amine in a mixed liquid of water and an organic solvent to give a crystal of a naphthalenedicarboxylic acid amine salt; and obtaining a purified naphthalenedicarboxylic acid from the crystal of the naphthalenedicarboxylic acid amine salt, wherein (1) in the step of forming the naphthalenedicarboxylic acid amine salt by adding an amine to the slurry that contains water, an organic solvent and a naphthalenedicarboxylic acid, the amine addition rate is from 0.002 to 0.4 mol/min relative to one mol of the naphthalenedicarboxylic acid, or (2) an amine is added to the aqueous solution prepared by dissolving the naphthalenedicarboxylic acid amine salt in water, or to the liquid prepared through solid-liquid separation of the aqueous solution to insolubilize and precipitate the metal component, and the precipitated metal component is removed through solid-liquid separation.

Abstract: The present invention provides a simple industrial process for producing an L- or D-optically active ?-methylcysteine derivative or its salt, which is a useful pharmaceutical intermediate, from readily available, inexpensive raw materials. In a process for producing an L- or D-optically active ?-methylcysteine derivative or its salt, a racemic N-carbamoyl-?-methylcysteine derivative or its salt is D-selectively cyclized with hydantoinase to produce a D-5-methyl-5-thiomethylhydantoin derivative or its salt and an N-carbamoyl-?-methyl-L-cysteine derivative or its salt, which are then subjected to deprotection of the amino group and the sulfur atom, and hydrolysis.

Abstract: The invention relates to a catalyst composition comprising a mixed oxide of vanadium, titanium, and phosphorus. The titanium component is derived from a water-soluble, redox-active organo-titanium compound. The catalyst composition is highly effective at facilitating the vapor-phase condensation of formaldehyde with acetic acid to generate acrylic acid, particularly using an industrially relevant aqueous liquid feed. Additionally, the catalyst composition is catalytically active towards the formation of acrylic acid from methylene diacetate and methacrylic acid from methylene dipropionate; both reactions are carried out with high space time yields.

Abstract: The invention relates to a method for producing and using a solid sodium diformate having a high formic acid content, to the use thereof in animal foods in the form of an acidifier, preservatives, ensilage auxiliary agents, fertilizers, and a growth and productivity-stimulating agent and the inventive animal food additives containing sodium diformate.

Abstract: A process for preparing phosgene by reaction of a feed stream (1) obtained by combining and mixing a chlorine feed stream (2) and a carbon monoxide feed stream (3), with the carbon monoxide being introduced in a stoichiometric excess over chlorine, in catalyst tubes filled with beds of activated carbon in a reactor R having a bundle of catalyst tubes, to give a product gas mixture (4) which is separated into a liquid, phosgene-comprising product stream (5) and an offgas stream (6) comprising carbon monoxide which is discharged via a pressure-regulating valve, where the reaction of the feed stream (1) in the reactor R and the separation of the product gas mixture (4) are carried out under a pressure in the range from 2.0 to 6.

Abstract: The invention relates to highly active and selective catalysts for alkyne metathesis. In one aspect, the invention includes a multidentate organic ligand wherein one substrate-binding site of the metal center is blocked. In another aspect, the invention includes N-quaternized or silane-based multidentate organic ligands, capable of binding to metals. In yet another aspect, the invention includes N-quaternized or silane-based multidentate catalysts. The catalysts of the invention show high robustness, strong resistance to small alkyne polymerization and significantly enhanced catalytic activity compared to their corresponding non-quaternized or non-silane-based multidentate catalyst analogs.

Abstract: A novel material having high hole-transporting ability and a high glass transition temperature and having long-lasting durability is obtained. A benzofluorene compound represented by formula (1) is used. (In the formula, M is a substituted or unsubstituted aryl group having 6-40 carbon atoms or a substituted or unsubstituted heteroaryl group having 5-40 carbon atoms; Ar1 to Ar4 each independently is a substituted or unsubstituted aryl group having 6-40 carbon atoms or a substituted or unsubstituted heteroaryl group having 5-40 carbon atoms, provided that at least one of Ar1 to Ar4 is a substituent represented by any of the following formulae (2) to (5); and p is an integer of 0-2.

Abstract: Porous bulk materials formed of shape-persistent, non-collapsible, three-dimensional molecular cage building blocks are presented that are useful for a variety of applications including gas separation/storage, sensing, and catalysis.

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Abstract: The present invention relates to phenylcyclopropylamine derivatives. In particular, pharmaceutical compositions comprising phenylcyclopropylamine derivatives are provided. The compounds of this invention can, inter alia, be used for the treatment and the prevention of cancer as well as neurodegenerative diseases or disorders.

Abstract: A process for isolating at least one target compound, such as manool, geranyl linalool, ethyl guaiacol, eugenol, veratraldehyde, squalene, terpin, cholesterol, beta-sitosterol, campesterol, stigmasterol, stigmastenol and dehydroabietic acid, from biomass, the process including steps of: obtaining a condensate from a recovery evaporator, a reverse osmosis retentate of a condensate of a pulp and paper mill, or both, the condensate, retentate or both being substantially free of higher molecular weight (approximately >1000 Da) cellulose and/or lignin and/or lignin-derived material; optionally pH adjusting and filtering the condensate to collect insoluble material; extracting the condensate, the collected insoluble material, or both, with solid phase extraction (SPE), liquid-liquid extraction or solid-liquid extraction to produce an extract containing the at least one target compound; and optionally purifying the extract containing the at least one target compound by thermal fractionation, chromatographic separ

Abstract: Disclosed is a preparation method of the lycopene intermediate 3-methyl-4,4-dialkoxy-1-butaldehyde. The preparation method comprises the following steps: (1) reacting 2-methyl-3,3-dialkoxy-1-halopropane with magnesium powder in the solvent of anhydrous tetrahydrofuran at a temperature of 45˜65° C. to generate a mixture of Grignard reagents under the protection of an inert gas; and (2) adding N,N-disubstituted carboxamide to the mixture of Grignard reagents and reacting at a temperature of 10° C.˜35° C. to obtain 3-methyl-4,4-dialkoxy-1-butaldehyde. The process route of the present invention is simple and direct, the operation is easy, the conditions are mild and the yield is good, and thus the invention has commercial value.

Abstract: Described herein are mixed ethers and cosmetic and/or pharmaceutical preparations comprising mixed ethers. Certain mixed ethers have a melting range between ?25° C. and +70° C., wherein the width of the melting range comprises at least 30 temperature degrees and the maximum of the melting range is 35 ±10° C. These mixed ethers are obtainable for example by condensation reaction of a) 25 to 90% by weight of unbranched fatty alcohols with a chain length of 12 to 19 carbon atoms; b) 5 to 50 by weight of isostearyl alcohol; c) 0 to 35% by weight of a fatty alcohol with a chain length of 20 and/or 22 carbon atoms; and d) 0 to 25% by weight of a fatty alcohol having 8 and/or 10 carbon atoms.

Abstract: A method of preparing 2-methyl-4-phenylbutan-2-ol from a Grignard-type reaction of a benzylmagnesium halide with isobutylene oxide, and the use of the 2-methyl-4-phenylbutan-2-ol as a fragrance or flavoring, cosmetic agent, or detergent component.

Abstract: The present invention relates to a process for the preparation of 4-isopropyl-3-methylphenol (p-thymol) from distillation residues of thymol production.

Abstract: Provided is a method for producing an alcohol compound, which enables the alcohol compound to be obtained at a high yield from an amide compound or amine compound. The method for producing an alcohol compound, which is characterized by comprising allowing an alcohol in a supercritical state to act on the amide compound or amine compound in the presence of a carboxylic acid derivative to obtain the alcohol compound.

Abstract: A process for selective formation of ethanol from acetic acid includes contacting a feed stream containing acetic acid and hydrogen at an elevated temperature with catalyst comprising platinum and tin on a high surface area silica promoted with calcium metasilicate. Selectivities to ethanol of over 85% are achieved at 280° C. with catalyst life in the hundreds of hours.

Abstract: Disclosed is a process for the synthesis of 1,1,2,3-tetrachloropropene (HCC-1230xa) using 1,1,3-trichloropropene (HCC-1240za) and/or 3,3,3-trichloropropene (HCC-1240zf) and Cl2 gas as the reactants, wherein the process takes place in a single reactor system. Before this invention, HCC-1230xa was made in a two-step process using HCC-1240za/HCC-1240zf and Cl2 gas, and the processing was conducted using two separate reactors.

Abstract: A method for obtaining diesel fuel from vegetable or animal oils through the addition of hydrogen in the presence of catalysts under suitable temperature and pressure conditions is described. The method is different from other similar methods in that it involves the use of space velocities of between 5.1 h-1 and 9 h-1, thereby enabling a reduction in the size of the reactor and in hydrogen consumption, as well as lowering construction and operating costs. The invention also relates to the products obtained using said method, which have demonstrated that in additions, even below 10%, they improve the performance of diesel engines, thereby lowering fuel consumption.

Abstract: Technologies to convert biomass to liquid hydrocarbon fuels are currently being developed to decrease our carbon footprint and increase use of renewable fuels. Since sugars/sugar derivatives from biomass have high oxygen content and low hydrogen content, coke becomes an issue during zeolite upgrading to liquid hydrocarbon fuels. A self-sustainable process was designed to reduce the coke by co-feeding sugars/sugar derivatives with the paraffin products from hydrogenation of sugars/sugar derivatives. Paraffins without complete conversion result in products with less aromatics and relatively low density compared with the products directly from zeolite upgrading. Thus, the process is more economically favorable.

Abstract: The present invention provides a process for preparing cycloheptene and derivatives thereof by ring-closing metathesis of unsymmetric 1,8-dienes whose C—C double bond at the 8 position is nonterminal. Cycloheptene and the cycloheptanone, cycloheptylamine, cycloheptanecarbaldehyde, cycloheptanecarboxylic acid and cycloheptanecarbonyl chloride conversion products thereof, and the derivatives thereof, are important synthesis units for active ingredient compounds. The ring-closing metathesis is preferably performed as a reactive distillation. The unsymmetric 1,8-dienes for the ring-closing metathesis can be obtained by catalytic decarbonylation or oxidative decarboxylation from the corresponding unsaturated carboxylic acids or carboxylic acid derivatives.

Abstract: The present invention provides an improved process for producing an alkylated aromatic compound from an at least partially untreated alkylatable aromatic compound having catalyst poisons, wherein said alkylatable aromatic compound stream is treated to reduce catalyst poisons with a treatment composition having a surface area/surface volume ratio of greater than or equal to 30 in?1 (12 cm?1) in a treatment zone separate from an alkylation reaction zone under treatment conditions including a temperature of from about 30° C. to about 300° C. to form an effluent comprising said treated alkylatable aromatic compound.

Abstract: A new family of crystalline aluminosilicate zeolites has been synthesized that has been designated UZM-43. These zeolites are similar to previously known ERS-10, SSZ-47 and RUB-35 zeolites but are characterized by unique x-ray diffraction patterns and compositions and have catalytic properties for carrying out various hydrocarbon conversion processes. Catalysts made from these zeolites are useful in hydrocarbon conversion reactions.

Abstract: A method of making a catalyst for use in oligomerizing an olefin comprising a chromium-containing compound, a pyrrole-containing compound, a metal alkyl, a halide-containing compound, and optionally a solvent, the method comprising contacting a composition comprising the chromium-containing compound and a composition comprising the metal alkyl, wherein the composition comprising the chromium-containing compound is added to the composition comprising the metal alkyl.

Abstract: A process for the metathesis of olefins has been developed. The process comprises contacting a hydrocarbon feedstock with a catalyst at metathesis conditions. The catalyst comprises a tungsten compound, which contains at least one tungsten-fluoro bond, dispersed or grafted onto a support. A specific example of the catalyst is the compound WOF(CH2CMe3)3 grafted onto a silica support. The feedstock comprises a first and a second olefin wherein the second olefin has a carbon number of at least two greater than the first olefin and the product is an olefin with a carbon number intermediate between the first and second olefin. Specifically the process produces propylene from ethylene and butylene.

Abstract: One exemplary embodiment can be a process for fluid catalytic cracking. The process may include providing a first feed having a boiling point of about 180-about 800° C. to a first riser reactor, and providing a second feed having first and second parts to a second reactor. Typically, the first part includes one or more C5-C12 hydrocarbons and a second part includes one or more C4-C5 hydrocarbons. Generally, an effective amount of the second part is combined with the first part to maximize production of propene.

Abstract: An aromatics complex producing one or more xylene isomers offers a large number of opportunities to conserve energy by heat exchange within the complex. One previously unrecognized opportunity is through providing two parallel distillation columns operating at different pressures to separate C8 aromatics from C9+ aromatics. The parallel columns offer additional opportunities to conserve energy within the complex through heat exchange in associated xylene recovery facilities.

Abstract: Methods for converting toxic waste, including nuclear waste, to quasi-natural or artificial feldspar minerals are disclosed. The disclosed methods may include converting, chemically binding, sequestering and incorporating the toxic waste into quasi-natural or artificial Feldspar minerals. The quasi-natural or artificial feldspar minerals may be configured to match naturally occurring materials at a selected disposal site. Methods for the immediate, long term, quasi-permanent disposal or storage of quasi natural or artificial feldspar materials are also disclosed.

Abstract: A method and apparatus for the stabilization and safe removal of buried waste that is tested and classified as being transuranic or not transuranic waste and disposed accordingly. The buried waste (usually in vertical pipe units) is enclosed in a casing and ground and mixed with the surrounding soil. This process allows for chemical reactions to occur that stabilizes the mixture. The entire process is contained within the casing to avoid contamination. In situ or external testing is done for radio isotopes to classify the waste. If it is classified as transuranic the waste is removed in a controlled way into a retrieval enclosure and disposed off in drums. If the waste is not transuranic then grout is introduced into the mixture, allowed to set and the resulting monolith is removed and buried in trenches.