Abstract: This present invention relates to a screening method for rapidly identifying the hybridomas upon cell size and the expression of an exogenous label such as fluorescence labeling. This method of this present invention can largely shortens the time cost for antibody development by saving the time period with comparison of traditional methods using cell culture with media such as HAT medium.

Abstract: Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including the detection of levels of variety of biomarkers diagnostic of prostate cancer, including filamin A alone, or in combination with one or more additional biomarkers of prostate cancer, including, PSA, keratin 4, keratin 7, keratin 8, keratin 15, keratin 18, keratin 19, tubulin-beta 3, filamin B, and LY9. Additionally, age can be used as a predictor variable. The invention also provides methods of treating prostate cancer which rely on diagnostic information obtained based on the detection of biomarkers of prostate cancer, including filamin A alone, or in combination with one or more additional biomarkers of prostate cancer, including, PSA, keratin 4, keratin 7, keratin 8, keratin 15, keratin 18, keratin 19, tubulin-beta 3, filamin B, LY9, and/or age. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.

Abstract: The present invention generally relates, in some embodiments, to methods of determining a patient's prognosis for recurrence of prostate cancer and/or determining a course of treatment for prostate cancer following a radical prostatectomy.

Abstract: The present invention relates to a method for the diagnosis, prognosis, and monitoring of cancer, such as early or late stage ovarian cancer, in a subject by detecting Bcl-2 in a biological sample from the subject, preferably a urine or blood sample. Bcl-2 may be measured using an agent that detects or binds to Bcl-2 protein or an agent that detects or binds to encoding nucleic acids, such as antibodies specifically reactive with Bcl-2 protein or a portion thereof. The invention further relates to kits for carrying out the methods of the invention. The invention further relates to a device for the rapid detection of Bcl-2 in a bodily fluid and methods for rapidly measuring Bcl-2 in a bodily fluid.

Abstract: Novel phenyl-glyoxal based anti-citrulline probes and methods of synthesis are provided. Methods of use, such as, the development of methods for monitoring substrate citrullination over time; for identifying citrullinated proteins from cells are described.

Abstract: The present invention relates to a method of monitoring live cells, comprising the sequential steps of: (i) contacting the cells with self-assembled constructs associated with an imaging agent at t=0; (ii) incubating the cells for a period of time t1; (iii) imaging at least a sample of the live cells by means of the said imaging agent after time t1; wherein in step (i), at least some of the constructs are taken up into the cells; and wherein the constructs comprise an amphiphilic block copolymer having a hydrophilic and hydrophobic block.

Abstract: Therapeutic compositions for treating diseased cells such as cancer cells in a patient, formulated from a plurality of therapeutic agents selected from radiopharmaceuticals, chemotherapeutic agents and radionuclide labeled antibodies. Methods for predicting the response of an individual patient's cells to therapeutic intervention are also disclosed.

Abstract: The present disclosure discloses a non-invasive wireless glucose level monitoring device. The device is fitted into a contact lens and can analyze glucose levels in tear fluid. The results of the analysis can be continuously transmitted to a nearby receiver and uploaded to a computer, mobile device or server.

Abstract: The present invention provides an accurate and reliable method to detect acute cardiovascular syndromes or disorders and to detect acute cardiovascular syndromes or disorders at earlier time points such that more aggressive interventions can be used in high risk subjects

Abstract: The present invention relates to the discovery that altered levels of D-DT (also known as MIF-2) are associated with disorders and diseases. Thus, the present invention relates to compositions and methods useful of the assessment, diagnosis, characterization, prevention and treatment of disorders and diseases associated with an elevated level of D-DT. The present invention also relates to compositions and methods useful of the assessment, diagnosis, characterization, prevention and treatment of disorders and diseases associated with a reduced level of D-DT.

Abstract: The invention provides methods for predicting, diagnosing or monitoring acute cardiac disorders, cardiac transplant rejection, or distinguishing acute cardiac disorders from pulmonary disorders, by measuring BNP signal peptide levels in a sample taken from a subject shortly after onset of, or presentation with the disorder or transplant rejection.

Abstract: In accord with one aspect, a microfluidic coagulation assessment device defining a plurality of microchannels is provided, wherein a blood sample is driven through the microchannels at a substantially constant flow rate and a controller is configured to, in combination with a timer and a pressure sensing device, determine a first pressure value (or flow value) at an initiation of flow, a first time (Tpg) at which a second pressure value is about twice the determined first pressure value, and a second time (Tpf) at which a third pressure value is about (1+e) times the determined first pressure value and establish a subject coagulation model predictive of channel occlusion therefrom. In another aspect, the blood sample is driven through the microchannels at a substantially constant pressure and a controller is configured to, in combination with a timer and a flow sensing device make the determination based on flow rate.

Abstract: Disclosed are methods and systems for measuring serotonin in a sample using liquid chromatography and mass spectrometry.

Abstract: Methods, assays, and products for the detection of small molecules are provided. In one aspect, for example, a method of detecting a small molecule in a sample can include reacting together a first half of a DNA split aptamer having a first reactive group coupled thereto, a second half of a DNA split aptamer having a second reactive group coupled thereto, where the DNA split aptamer is selective for the small molecule, and a sample containing the small molecule. The first half and the second half bind to the small molecule and the first reactive group and the second reactive group react to form an aptamer ligation product of the first half and the second half. The method can also include assaying for the aptamer ligation product in order to detect the small molecule presence in the sample.

Abstract: The invention relates to a device for bringing an immobilised reactant into contact with at least one fluid, said device comprising: a basin having a bottom surface from which an upper side of at least one elevated portion projects into the interior of the basin, and said at least one elevated portion having a channel running, preferably perpendicular to the bottom surface of the basin, from the bottom surface of the basin to the upper side of the portion, and leading into at least one outlet opening on the upper side of the elevated portion, wherein the channel is fed from at least one fluid reservoir via a supply element by means of a pump device, said reservoir containing the at least one fluid; a holding device designed to detachably hold at least one object carrier, preferably a plurality of object carriers, having at least one surface of adhesion to the immobilised reactant, in such a way that the adhesion surface is facing the interior of the basin, and the upper side of the elevated portion and the ad

Abstract: An aspiration apparatus adapted to allow aspiration verification of a liquid such as of a biological liquid or reagent liquid, especially at low aspiration volumes (e.g., less than 25 ?L). The apparatus includes a pump operable at an operating frequency, the pump optionally including a pumping chamber, a probe having a probe interior, a main supply line containing a backing liquid coupled to and extending from the pump and including the probe interior, a striction coupled to the main supply line, or the pump chamber, if present, and a reservoir fluidly coupled to the striction, wherein the striction is sized to minimize backing liquid flow through the striction at one or more disturbance frequencies above the operating frequency. Systems and methods for carrying out the liquid aspiration are provided, as are other aspects.

Abstract: A system for predicting exterior ballistics has first and second bullet detectors operable to detect the passage of a bullet, the first and second bullet detectors being spaced apart by a selected detector spacing distance, the first and second bullet detector each being connected to a common time signal facility that generates a time signal, the first bullet detector being operable to generate a first time of passage based on the time signal, the second bullet detector being operable to generate a second time of passage based on the time signal, the first bullet detector being operable to measure a first bullet velocity, a controller in communication with the first and second bullet detectors, and the controller operable based on the difference between the first time and the second time, and based on the first bullet velocity to calculate a ballistic characteristic for the bullet.

Abstract: An air pressure probe (APP) relates to the field of aviation and is intended to determine aircraft flight parameters or wind tunnel flow parameters. The APP comprises a head part with intake holes located thereon, which are connected by channels to couplers, and a support, attached to the head part from behind. The surface of the head part is provided with flow vortex generators. The generators can be in the form of indentations or protrusions of various shapes on the surface of the air pressure probe, or in the form of ribs formed as a result of the mating of elements of the flat or curved planes that form the surfaces of the head part and the support. The technical result is an increased operational range of measurement and a wider field of practical application.

Abstract: An acceleration sensor includes a detection device, an opposed electrode, and a top lid. The detection device includes an active layer, a base layer, an oxide layer disposed between the active layer and the base layer, a first insulating layer, a contact portion, and a self-check electrode. The first insulating layer is disposed on the active layer at a side opposite to the oxide layer and provided with a first opening. The contact portion is disposed on a part of the first insulating layer at a side opposite to the active layer and includes a first metal layer connected to the active layer through the first opening. The opposed electrode is disposed at a location opposing the self-check electrode, and the top lid supports the opposed electrode.

Abstract: Accelerometers and associated techniques for detecting motion are described. For a resonant accelerometer, an externally-applied acceleration can cause a change in the electrical spring constant Ke of the electromechanical system. A resonant accelerometer can be driven to resonate in a bulk acoustic wave mode of vibration, which can have a high resonant frequency. Other accelerometers and associated techniques are disclosed.

Abstract: A physical quantity sensor includes: a base; a cover; a function element provided inside a cavity formed by the base and the cover; and a protection film with which a principal surface of the base, a bonding boundary portion between the principal surface of the base and the cover, and the cover are coated continuously, wherein the protection film is an inorganic material film or an organic semiconductor film.

Abstract: A method of improving accuracy of measurements of at least one motion sensor included in an electronic device, including receiving a candidate measurement associated with the electronic device from the at least one motion sensor; detecting an electronic device state associated with the electronic device, the electronic device state including one from among a static state and a motion state; computing a compensation parameter based on the candidate measurement and the electronic device state; and correcting the candidate measurement based on the computed compensation parameter.

Abstract: Methods and apparatuses are provided for automatically controlling and stabilizing aspects of a scanning probe microscope (SPM), such as an atomic force microscope (AFM), using Peak Force Tapping (PFT) Mode. In an embodiment, a controller automatically controls periodic motion of a probe relative to a sample in response to a substantially instantaneous force determined, and automatically controls a gain in a feedback loop. A gain control circuit automatically tunes a gain based on separation distances between a probe and a sample to facilitate stability. Accordingly, instability onset is quickly and accurately determined during scanning, thereby eliminating the need of expert user tuning of gains during operation.

Abstract: Apparatus and techniques for extracting information carried in higher eigenmodes or harmonics of an oscillating cantilever or other oscillating sensors in atomic force microscopy and related MEMs work are described. Similar apparatus and techniques for extracting information using contact resonance with multiple excitation signals are also described.

Abstract: Capacitive sensor assemblies for electronic devices, and methods of forming capacitive sensor assemblies. The capacitive sensor assembly may include a top component having an intermediate layer formed on the top component, a bottom component positioned opposite the top component, a silicone layer positioned between the top component and the bottom component, and a first electrical trace positioned adjacent the silicone layer.

Abstract: A circuit for compensating an offset voltage in an amplifier or a DC component in a signal supplied to the amplifier comprises the amplifier and a first voltage source. The amplifier has at least one measurement signal port and at least two contacts for a supply voltage. Each of two contacts is connected to a different terminal of the first voltage source. The potential at each contact is separated from a ground potential and from an external supply potential.

Abstract: Multi-layer capacitor divider voltage sensors include a plurality of voltage sensor conductive layers having sensor to ground interface surfaces. Respective voltage sensor conductive layers are connected to each other and sensor output voltage Vs by continuations of material forming the interface surfaces extending therebetween. The voltage sensors also include a plurality of conductive ground layers connected to electrical ground, the ground layers interleaved with the voltage sensor conductive layers so that a conductive ground layer resides between adjacent conductive voltage sensor layers. A first voltage sensor conductive layer (closest to a line conductor) is electrically connected to the other conductive voltage sensor layers and output voltage Vs and has a sensor to conductor interface surface with a corresponding interface area.

Abstract: A self-contained branch circuit monitor 2 is has a small form factor configured to fit in the limited space available in a load center 1, in association with a branch circuit breaker 10A occupying a branch location slot 45 in the load center 1. A flexible printed circuit board 4 is wrapped around an outside circumference of a toroidal sensor coil 6 of a current transformer. A current monitoring circuit 15 is formed on the flexible printed circuit board. The monitoring circuit is electrically connected to leads 7, 9 from the sensor coil and is powered by current 17 induced in the sensor coil from current 5 in the branch circuit wire. A branch circuit wire 3A is threaded through the current transformer's center. A transmitter 22 is part of the flexible printed circuit board, to transfer the monitored current data to other locations.

Abstract: A current detection system includes: first and second magnetic plates arranged in parallel with a predetermined distance; a bus bar for flowing current; and a magneto-electric conversion element converting a lateral direction component of a measurement object magnetic flux, generated by current flowing through the bus bar, to an electric signal. When an external magnetic flux in a lateral direction passes through an accommodation space between the first and second magnetic plates, a trajectory of the external magnetic flux is bent by the first and second magnetic plates, and the accommodation space is divided into a permeable space, through which the external magnetic flux passes, and a non-permeable space, through which the external magnetic flux does not pass. The bus bar is arranged in the accommodation space. The magneto-electric conversion element is arranged in the non-permeable space. The bus bar and the magneto-electric conversion element are lined in the height direction.

Abstract: An electrical panel meter system may include a controller and a plurality of meter modules. Each meter module may be configured to monitor, read, and store at the meter module electrical data related to electrical power provided to a respective branch circuit of the electrical panel meter system. The controller may be configured to issue a read command simultaneously to each meter module and to store a timestamp indicative of the issuance of the read command. The controller may also be configured to issue a send command sequentially to each meter module to transmit its stored electrical data reading. The controller may further be configured to append the stored timestamp to each received electrical data reading to create a timestamped electrical data reading suitable for use in power quality analyses. Methods of timestamping electrical data sampled in an electrical panel meter system are also provided, as are other aspects.

Abstract: An analogue measurement data detection system according to the present invention includes: a reference voltage generation circuit configured to generate and output a reference voltage; an analogue/digital converter configured to compare an analogue signal with die reference voltage outputted from the reference voltage generation circuit, and based on a differential voltage between the analogue signal and the reference voltage, generate and output a digital signal corresponding to the analogue signal. The reference voltage generation circuit is configured to cause the reference voltage to have such a temperature characteristic as to compensate for temperature characteristics of at least the analogue/digital converter and the reference voltage generation circuit.

Abstract: According to one embodiment, there is provided a semiconductor device. The semiconductor device includes a metering unit that operates under control of a first processor to measure electric power consumed, a communication unit that operates under the control of a second processor different from the first processor to perform communication, and a path connecting the metering unit and the communication unit.

Abstract: Embodiments of the present disclosure disclose a method for on-site monitoring of performance of energy devices. The method comprises measuring a value associated with one or more energy parameters of one or more energy devices in real time. The method further comprises comparing the measured value of the one or more energy devices with a predefined set of tolerance values corresponding to the one or more energy parameters of the one or more energy devices. The method further comprises indicating a result of the comparison on a display unit associated with the testing apparatus for on-site monitoring performance of the one or more energy devices.

Abstract: An improved counter may implement dynamic frequency measurement while also remaining fully backwards compatible with traditional frequency measurement methods. The counter may operate according to low-frequency, large range, and/or high frequency modes of operation. It may be programmable with a divisor value associated with the large range operating mode, and a measurement time associated with the high frequency mode of operation. The divisor and measurement time settings may be enabled or disabled, and when either setting is disabled, the counter becomes backwards compatible with traditional frequency measurement methods. The counter may also be provided with inputs representative of the desired type of measurement and the minimum and maximum expected values for the signal to be measured. The counter may perform the frequency measurement according to any one or more of the operating modes, and return a measurement result obtained in the operating mode that completes the measurement first.

Abstract: A method implemented in a system of signal processing for phase-amplitude coupling (PAC) and amplitude-amplitude coupling (AAC), wherein comprises: decomposing a non-stationary signal by an ensemble empirical mode decomposition (EEMD) into a plurality of intrinsic mode functions (IMFs), receiving a phase function and an amplitude function from the IMFs, then comparing the phase function with the amplitude function on a time domain to generate a plurality of scattering plots. Further more, multiplying the scattering plots by the modulation index to generate a frequency spectrum. The following information will be illustrated the different part of PAC and AAC.

Abstract: Wideband capacitive sensing (single-ended or differential) is based on a modulated sense (capacitance) signal. A carrier/drive signal path modulates a reference signal with a carrier signal (such as fixed frequency or spread spectrum) to generate a carrier/drive signal, driven (with optional pre-scaling) out through an output node (to sense capacitor(s)). A sense signal path receives at an input/summing node up-modulated sense capacitance signal(s), corresponding to measured capacitance up-modulated to the carrier frequency, and, after filtering (optional) and amplification, demodulates the up-modulated sense capacitance signal with the carrier signal, to generate a demodulated sense capacitance signal corresponding to measured capacitance, which can be converted to sensor data. Sense signal path amplification can use charge amplification (capacitor feedback), or transimpedance amplification (resistor feedback).

Abstract: An electrified vehicle has first and second DC buses and a chassis ground. A leakage detector has a detector switch and detector resistor in series between the first bus and chassis ground. A voltage measured across the detector resistor is proportional to a leakage resistance between the second bus and chassis. An inverter has a plurality of phase legs, each having first and second phase switches coupled between the buses. An AC traction motor has phases coupled to the phase legs. An inverter control circuit receives data messages having a predetermined latency period from the detector identifying a measured leakage resistance. Switching events are detected during which a phase switch is closed for a duration greater than the latency period. An electrical short is indicated if the measured leakage resistance in a data message received during a detected switching event is less than a predetermined threshold.

Abstract: A per-chip equivalent oxide thickness (EOT) circuit sensor resides in an integrated circuit. The per-chip EOT circuit sensor determines electrical characteristics of the integrated circuit. The measured electrical characteristics include leakage current. The determined electrical characteristics are used to determine physical attributes of the integrated circuit. The physical attributes, including EOT, are used in a reliability model to predict per-chip failure rate.

Abstract: To provide a sensor device which is capable of high temperature detection using self-heat generation without providing a dedicated terminal and suppresses an increase in cost with an increase in chip occupation area due to the addition of a test pad. A sensor device is configured to include an active logic switching circuit for switching an active logic of an output driver and perform a heating inspection while switching the active logic of the output driver during an inspection process with the output driver as a heat generation source.

Abstract: Through-silicon via (TSV) crack sensors for detecting TSV cracks in three-dimensional (3D) integrated circuits (ICs) (3DICs), and related methods and systems are disclosed. In one aspect, a TSV crack sensor circuit is provided in which doped rings for a plurality of TSVs are interconnected in parallel such that all interconnected TSV doped rings may be tested at the same time by providing a single current into the contacts of the interconnected doped rings. In another aspect, a TSV crack sensor circuit is provided including one or more redundant TSVs. Each doped ring for a corresponding TSV is tested independently, and a defective TSV may be replaced with a spare TSV whose doped ring is not detected to be cracked. This circuit allows for correction of a compromised 3DIC by replacing possibly compromised TSVs with spare TSVs.

Abstract: Methods of operating integrated circuit devices are useful in testing impedance adjustment. Methods include connecting a node of the integrated circuit device to a first voltage node through a reference resistance and connecting the node to a second voltage node through a termination device, and comparing a voltage level at the node to a reference voltage for at least one resistance value of the termination device. When no available resistance value of the termination device generates a voltage level at the node that is deemed to match the reference voltage, the voltage level of the reference voltage may be altered, and the voltage level at the node may be compared to the altered reference voltage. When the voltage level at the node is deemed to match the altered reference voltage, the termination device may be deemed as passed. Otherwise, the termination device may be deemed as failed.

Abstract: A system for electromigration testing is disclosed. The system includes a conductive member, a cap layer of insulative material over at least a portion of a top surface of the conductive member, a cathode conductively connected to a first end of the conductive member; an anode conductively connected to a second end of the conductive member, and a current source conductively connected to the cathode and the anode. A plurality of sensory pins are disposed along a length of the conductive member between the first end and the second end of the conductive member. The sensory pins are conductively connected to a bottom surface of the conductive member. At least one measurement device is conductively connected to at least one sensory pin of the plurality of sensory pins. The at least one measurement device determines a resistance of at least one portion of the conductive member.

Abstract: A highly flexible, compact, lightweight, and portable testing system for use with radiation testing activities. The testing system is coupled to a device under test (DUT), which can be positioned in such a way that the top of the die package is exposed to the direct ion beam during radiation testing. A variety of sensors, onboard memory systems, programmable interfaces, onboard control systems, data output devices, and different types of interfaces are also provided which provide an ability to perform testing procedures while having a maximum ability to orient the DUT and perform a wide variety of testing currently unavailable.

Abstract: A master controller includes: an interface to a CPU, an input port configured to receive a digital signal, and an output port configured to transmit a digital signal. Slave controllers each include: an interface to a device, an input port configured to receive a digital signal, and an output port configured to transmit a digital signal. A first chain bridge includes: a first set of input and output ports that couple the first chain bridge to a first chain of nodes each coupled to neighboring nodes by conductor paths in a closed loop, where the nodes of the first chain include the master controller, and a second set of input and output ports that couple the first chain bridge to a second chain of nodes each coupled to neighboring nodes by conductor paths in a closed loop, where the nodes of the second chain include multiple slave controllers.

Abstract: A method for performing scan testing using a scan chain having a plurality of storage elements is described. During a capture phase, each storage element of the scan chain stores data from a first data input of the storage element synchronously to a clock signal. And during a shift phase, a scan pattern is shifted into the scan chain in which each storage element stores data from a second data input of the storage element asynchronously with to the clock signal.

Abstract: A tester for integrated circuits on a silicon wafer may include an input/output connection for testing an integrated circuit and circuitry causing the tester to perform: transferring a data frame to the integrated circuit via the input/output connection, the data frame including a time reference for the data included in the data frame, a field for validating the time reference and a data field including at least one integrated-circuit test command; and receiving a data frame via the input/output connection, the data in the data frame received having a duration that is a multiple of the time reference.

Abstract: The disclosure describes a process and apparatus for accessing devices on a substrate. The substrate may include only full pin JTAG devices (504), only reduced pin JTAG devices (506), or a mixture of both full pin and reduced pin JTAG devices. The access is accomplished using a single interface (502) between the substrate (408) and a JTAG controller (404). The access interface may be a wired interface or a wireless interface and may be used for JTAG based device testing, debugging, programming, or other type of JTAG based operation.

Abstract: Provided is a debugging system including: a processor; and a debugger arranged between the processor and an external bus to determine whether or not an address of a job request including an instruction request or a data access request transferred from the processor to the external bus is hit on a preset address, wherein if the address of the job request is hit on the preset address, the debugger does not transfer the job request to the external bus, so that the processor is allowed to be stopped.

Abstract: Techniques of debugging a computing system are described herein. The techniques may include an apparatus having an all-in-one port. The all-in-one port may include a configuration channel and a sideband channel. The sideband channel is configured to default to a debug mode when the configuration channel is not communicatively coupled to an external device.

Abstract: A test circuitry for testing an interconnection between interconnected dies includes a cell embedded within one of the dies. The cell includes a selection logic module that includes a first multiplexer configured to receive a first control signal and provide a first output test signal, and a second multiplexer configured to receive a second control signal and provide a second output test signal. The cell includes a scannable data storage module coupled to the first multiplexer; and a transition generation module configured to receive a third control signal; wherein the first and second output test signals are generated based on respective states of the first, second, and third control signals, and wherein the test circuitry is configured to use the first and second output test signals to perform at least two of: a DC test on the interconnection, an AC test on the interconnection, and a burn-in-test on the interconnection.