Patents Issued in October 6, 2016
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Publication number: 20160291010Abstract: The present invention relates to an immunochromatography strip sensor capable of measuring a biomaterial concentration over a broad concentration range, and a method for measuring a biomaterial concentration over a broad concentration range using the sensor. A detection method using the sensor according to the present invention can accurately measure an antigen concentration over a broad concentration range, and achieve a low cost, rapidity and convenience, and thus the method is suitable for a point of care test (POCT) requiring rapidity and high sensitivity.Type: ApplicationFiled: November 11, 2014Publication date: October 6, 2016Inventors: Min Gon KIM, Hyou Arm JOUNG, Young Kyoung OH
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Publication number: 20160291011Abstract: The invention provides compositions and methods for determining cardiodiabetes status in a subject. The invention also provides compositions and methods for treating a subject experiencing cardiodiabetes.Type: ApplicationFiled: November 4, 2015Publication date: October 6, 2016Applicant: IKFE lnstitut fur Klinische Forschung und Entwicklung GMBHInventors: Andreas PFUETZNER, Thomas FORST
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Publication number: 20160291012Abstract: This disclosure provides a method for detecting infection of an animal by Mycobacterium bovis. The method generally includes obtaining a biological sample from a host animal at risk of being infected by Mycobacterium bovis and analyzing the sample for the presence or absence of at least one M. bovis polypeptide. In some embodiments, the method can further include analyzing the sample for the presence or absence of at least one M. bovis lipid. In some embodiments, the method can further include detecting at least one host polypeptide whose expression is greater in a host infected with M. bovis compared to expression in a host known to be uninfected with M bovis.Type: ApplicationFiled: November 21, 2014Publication date: October 6, 2016Inventors: Srinand Sreevatsan, Elise Lamont
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Publication number: 20160291013Abstract: Methods and kits for sampling mucous from within a sinus to determine if a single sample includes one or more bacterial types indicating bacterial sinusitis.Type: ApplicationFiled: March 30, 2016Publication date: October 6, 2016Inventors: Joseph SKRABA, Oriana E. HAWKINS, Soumya MOHANA-SUNDARAM
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Publication number: 20160291014Abstract: The invention provides bioconjugates of heterocylic compounds such as S-adenosylmethionine and S-adenosylhomocysteine with biotin or digoxigenin. The bioconjugates also include carbon and nitrogen linker moieties of varying length that are used to attach such compounds to biotin or digoxigenin. The conjugates are useful in immunoassays. The invention provides a method for detecting SAM and SAH, comprising the steps of: (a) preparing the following components: (i) bio-conjugates of SAM, SAM analogs or SAH; (ii) an europium, a terbium cryptate or other fluorophore as a donor that has a specific ligand for the tracer in the bio-conjugates of (i); (iii) an acceptor fluorescent dye that has the excitation spectra overlap those of donor's emissions and has an antibody specific for SAM or SAH labeled; (b) addition of the biological fluid containing said SAM or SAH; and (c) spectroscopic measurement of the fluorescence of the donor and the fluorescence of from the acceptor.Type: ApplicationFiled: April 5, 2016Publication date: October 6, 2016Inventor: Xiujuan Hao
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Publication number: 20160291015Abstract: The invention relates to a method for quantifying the level of agglutination of particles in a sample, in particular a biological sample, and notably blood. The biological sample is positioned between a light source and a matrix photodetector. The image acquired by the photodetector is representative of the level of agglutination of the particles in the sample. The light source emits a light wave, the spectral band of which extends an optimum 400 and 600 nm, which constitutes an optimum an excessively low absorption and excessively high absorption, given the thickness of the sample.Type: ApplicationFiled: March 31, 2016Publication date: October 6, 2016Applicant: Commissariat a L'Energie Atomique et aux Energies AlternativesInventors: Maxime HUET, Jean-Guillaume COUTARD
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Publication number: 20160291016Abstract: Methods of stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's PTP? expression and/or activity and/or PIPK1? expression and/or activity. Also provided are methods of predicting the risk of developing a scoliosis also based on the subject's PTP? expression and/or activity and/or PIPK1? expression and/or activity; and methods of increasing GiPCR signaling in cells of a subject in need thereof comprising administering to the subject's cells an effective amount of an inhibitor of PIPK1? tyrosine phosphorylation; an activator of PIPK1Y tyrosine dephosphorylation; and/or an inhibitor of PIPK1? expression and/or activity.Type: ApplicationFiled: June 17, 2014Publication date: October 6, 2016Applicant: Chu Sainte-JustineInventors: Alain Moreau, Marie - Yvonne Akoume Ndong, Mohamed Elbakry
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Publication number: 20160291017Abstract: The methods of the present invention, relate to the surprising determination that the level of phosphorylation of position 406 (e.g., a serine residue) of human eukaryotic initiation factor 4B (eIF4B), or a corresponding phosphorylatable amino acid of an ortholog thereof, serves as a biomarker for MELK enzymatic (e.g., kinase) and/or oncogenic activity. The methods of the present invention further relate to the surprising determination that the level of phosphorylation of position 3 (e.g., a threonine residue) and/or position 10 (e.g., a serine residue) and/or position 11 (e.g., a threonine residue) of human Histone M3, or a corresponding phosphorylatable amino acid of an ortholog thereof, also serves as a biomarker for MELK enzymatic (e.g., kinase) and/or oncogenic activity.Type: ApplicationFiled: November 12, 2014Publication date: October 6, 2016Inventors: Jean Zhao, Yubao Wang
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Publication number: 20160291018Abstract: The present disclosure provides methods of assessing cardiovascular risk in a subject and/or of treating a subject having or at risk of developing a cardiovascular disease or disorder. In some embodiments, the method comprises determining an activity level of PCSK9 and/or a level of PCSK9 in a sample obtained from the subject, and initiating or modifying a treatment regimen.Type: ApplicationFiled: April 6, 2016Publication date: October 6, 2016Inventor: Rebecca E. Caffrey, SR.
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Publication number: 20160291019Abstract: A system for detecting rare cells in a fluid is disclosed. The system includes a substrate and a mixture disposed on the substrate and including a carrier and a thermo-responsive polymer for capture and release of the rare cells. Also disclosed is a method for detecting rare cells in a fluid using a system including a substrate and a mixture that is disposed on the substrate. The mixture includes a carrier and a thermo-responsive polymer. The method includes providing the system and introducing a sample of fluid containing the rare cells into the system such that the sample interacts with the carrier for capturing the rare cells.Type: ApplicationFiled: April 6, 2016Publication date: October 6, 2016Inventors: Hyeun Joong Yoon, Apoorv Shanker, Jinsang Kim, Sunitha Nagrath, Vasudha Murlidhar
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Publication number: 20160291020Abstract: The present invention relates to monoclonal antibodies for the detection of HCV antigen. More specifically, the invention describes antibodies against HCV core antigen lipid binding domain and immunoassay methods, kits and compositions for use in detecting HCV infection.Type: ApplicationFiled: March 23, 2016Publication date: October 6, 2016Inventors: Robert Ziemann, April Ahlberg, David Hawksworth, Bryan Tieman, A. Scott Muerhoff, Christopher Marohnic, Kathy Otis
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Publication number: 20160291021Abstract: The present invention is in the technical field of breast cancer management, and more particularly relates to the diagnosis and/or prognosing of triple-negative breast cancer (TNBC). The invention is more particularly based on the finding that specific biomarkers are abberantly expressed in patients suffering from a triple-negative breast cancer recurrence, and are highly related to the aggressiveness of this disease, and thus to survival of said patient.Type: ApplicationFiled: November 24, 2014Publication date: October 6, 2016Inventors: Catherine Guette, Mario Campone, Olivier Coqueret, Benjamin Barre
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Publication number: 20160291022Abstract: The present invention is in the technical field of breast cancer management, and more particularly relates to the diagnosis of breast cancer. The invention is more particularly based on the finding that specific biomarkers (olfactomedin-4, neudesin and desmoplakin) are abberantly expressed in the blood of breast cancer patients.Type: ApplicationFiled: November 24, 2014Publication date: October 6, 2016Inventors: Catherine Guette, Pedro Raro, Olivier Coqueret, Benjamin Barre, Mario Campone
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Publication number: 20160291023Abstract: The subject invention pertains to devices and methods of isolating target cells from a population of cells. The devices comprise of microfluidic channels and aptamers and antibodies attached to the inner surface of the microfluidic channels, wherein the aptamers and the antibodies are capable of specific binding to one or more biomolecules present on the surface of the target cell. The methods of the current invention comprise passing the population of cells through the microfluidic channels to facilitate interaction and capture of the target cells by the aptamers and the antibodies attached to the inner surface of the microfluidic channels, washing to microfluidic channels by a washing solution to remove the cells non-specifically bound to the aptamers and the antibodies attached to the inner surface of the microfluidic channels, releasing the captured target cells from the microfluidic channels, and collecting the released target cells.Type: ApplicationFiled: November 20, 2014Publication date: October 6, 2016Inventors: ZHONGHUI HUGH FAN, JINLING ZHANG
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Publication number: 20160291024Abstract: Biomarkers and biomarker panels are provided for making ovarian cancer assessments, for example, diagnosing an ovarian cancer, predicting responsiveness of an ovarian cancer to an ovarian cancer therapy, and monitoring an ovarian cancer. A patient may further be treated in accordance with the classification. Also provided are methods, reagents, devices and kits for the use of these biomarkers in making ovarian cancer assessments.Type: ApplicationFiled: September 17, 2014Publication date: October 6, 2016Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYInventors: Atul J. Butte, Linda Anne Szabo, Purvesh Khatri, Bruce Xuefeng Ling
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Publication number: 20160291025Abstract: The present invention relates to the identification of biological markers of ovarian cancer. Specifically, cancer-associated autoantibodies to ANXA1, ARP3, SAHH, SERPH, ARAP1, OTUB1, ATP1A1, UBA1, and CFAH have been identified in subjects with early stage ovarian cancer. These autoantibodies can be utilised for a range of purposes including methods for detecting ovarian cancer, methods for screening for early stage ovarian cancer, and methods for assessing treatment response as well as disease progression and recurrence. The autoantibodies also represent prognostic markers of ovarian cancer development.Type: ApplicationFiled: September 18, 2014Publication date: October 6, 2016Applicant: ADELAIDE RESEARCH & INNOVATION PTY LTDInventors: Peter Hoffmann, Martin Oehler, Karina Martin
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Publication number: 20160291026Abstract: Methods are provided for predicting and diagnosing the presence of ovarian cancer, as well as for assessing the therapeutic efficacy of a cancer treatment and determining whether a subject potentially is developing cancer.Type: ApplicationFiled: March 31, 2016Publication date: October 6, 2016Inventors: Meredith C. Henderson, Rao Mulpuri, David E. Reese
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Publication number: 20160291027Abstract: The instant invention provides methods of prognosing the ability of a zearalenone analog compound to treat a cancer in a subject, methods of prognosing the ability of a zearalenone analog compound to inhibit the growth of a cancer in a subject, and methods of prognosing the ability of a zearalenone analog compound to promote the activation of apoptosis of a cancer in a subject. Methods of treating a cancer in a subject are also provided. The invention also pertains to methods of determining whether a cancer in a subject is sensitive to treatment with a zearalenone analog compound.Type: ApplicationFiled: March 2, 2016Publication date: October 6, 2016Inventors: Kenichi NOMOTO, John (Yuan) WANG, Sergei I. AGOULNIK
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Publication number: 20160291028Abstract: Method and pack for detecting and/or assaying annexin A3 from a mammal in blood or at least one derivative thereof.Type: ApplicationFiled: June 5, 2013Publication date: October 6, 2016Applicant: bioMerieuxInventors: Yasemin ATAMAN-ONAL, Genevieve CHOQUET-KASTYLEVSKY, Hader HAIDOUS, Sandrine MICHEL-BUSSERET, Catherine OTT
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Publication number: 20160291029Abstract: There are described novel fluorescent dyes, conjugates which include a radical of a dye and a biological or a synthetic moiety and diagnostic and in vivo assays utilizing such conjugates and other products including the dyes and conjugates.Type: ApplicationFiled: June 20, 2016Publication date: October 6, 2016Inventor: Ramdas P. PAI
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Publication number: 20160291030Abstract: Methods and compositions are provided for the analysis of rare cells or other biological entities in a population, by contacting the population with a labeling nanoparticle comprising a VLP conjugated to a light emitting moiety and a specific binding moiety, then detecting the presence of bound nanoparticle by light emission.Type: ApplicationFiled: November 7, 2014Publication date: October 6, 2016Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: James Robert SWARTZ, Christopher C. Vanlang
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Publication number: 20160291031Abstract: The present disclosure relates to methods for predicting time-to-delivery in pregnant women. The methods include predicting that a pregnant woman will deliver within a predetermined time frame if PAMG-1 is determined to be present at a level above a predetermined detection threshold in a vaginal fluid sample obtained from the pregnant woman. Also provided are methods for determining a patient's risk of preterm labor and/or spontaneous rupture of the chorioamniotic membrane.Type: ApplicationFiled: June 17, 2016Publication date: October 6, 2016Inventors: Anthony Ausiello, Ruben Salinas, Michael Thompson, Daniel J. Mackey, Kaitlyn Nardozzi, Michael Friedman
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Publication number: 20160291032Abstract: A method determines an amino acid sequence that binds to a target molecule or a base sequence encoding the same. The method pans for bringing a library constructed by a display method, followed by incubation. The method sequences for analyzing a base sequence before panning step and the polypeptide group of the library after panning by a next-generation sequencer, or determining an amino acid sequence based on a base sequence obtained by analyzing the base sequence of a nucleic acid encoding all the polypeptides by a next-generation sequencer. The method scores for evaluating and scoring, based on the results of the sequencing step, an amplification ratio. The method determines a sequence for selecting a polypeptide with a high score and determines an amino acid sequence of the polypeptide or a base sequence as an amino acid sequence that binds to the target molecule or as a base sequence of a nucleic acid encoding the polypeptide.Type: ApplicationFiled: November 21, 2014Publication date: October 6, 2016Inventor: Ryu OGAWA
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Publication number: 20160291033Abstract: Methods and compositions are provided for validating immunological detection reagents for use in detecting contaminating host cell components in a biological preparation.Type: ApplicationFiled: November 12, 2014Publication date: October 6, 2016Inventor: Tom Berkelman
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Publication number: 20160291034Abstract: Systems and methods for imaging of matrix vesicle-derived calcification are described. In one embodiment, the method comprises raising the pH of collagen stored in a soltion, thereby causing the collagen to come out of the solution to form a network, adding matrix vesicles to the network, resulting in calcifications, and imaging the formation of the calcification. The calcification process can be imaged in real time by confocal or reflected light microscopy.Type: ApplicationFiled: November 13, 2014Publication date: October 6, 2016Inventors: Joshua Daniel Hutcheson, Elena Aikawa, Masanori Aikawa
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Publication number: 20160291035Abstract: Provided herein is a method of monitoring the change of the alpha-4 integrin activities in an individual by correlating with the soluble vascular cell adhesion molecule (sVCAM) and/or soluble mucosal addressin cell adhesion molecule (sMAdCAM) levels. Particularly, this method can be used, for example, to evaluate the pharmacokinetics and pharmacodynamics (PK/PD) of an alpha-4 integrin inhibitor used to treat a disease associated with pathological or chronic inflammation.Type: ApplicationFiled: April 18, 2016Publication date: October 6, 2016Inventor: Alissa A. Chackerian
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Publication number: 20160291036Abstract: The present invention includes methods for selecting a therapy for improved cognition as well as prevention of cognitive loss/dysfunction using one or more endophenotypes comprising: obtaining a sample from a subject; measuring biomarkers that differentiate between an inflammatory, a metabolic, a neurotrophic, and a depressive endophenotype; and selecting a course of treatment for the subject based on whether the subject is scored as having a high or a low endophenotype for one or more of the inflammatory, a metabolic, a neurotrophic, and a depressive endophenotypes.Type: ApplicationFiled: November 26, 2014Publication date: October 6, 2016Inventor: Sid E. O'Bryant
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Publication number: 20160291037Abstract: The present invention provides detection reagents and method for determining risk of traumatic brain injury (TBI), assessment of the amount of neuronal damage, and/or susceptibility to neurodegenerative disease in a subject.Type: ApplicationFiled: March 31, 2016Publication date: October 6, 2016Inventors: Michael Sierks, Stephanie Williams
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Publication number: 20160291038Abstract: The present invention relates to a method for the immunological measurement using a hapten and an antibody binding to the hapten as a reference antibody, and a device for the immunological measurement using the reference antibody. According to the present invention, the method and the device for the immunological measurement can be used in an immunoassay by reflecting surrounding environments, for example, by reflecting a numerical value in a test zone, which is changed by external factors such as temperatures of a sample and a device, an amount and components of an injected sample, variations of the device, and the like, in a reference zone and changing the numerical value in the test zone, and can be useful in minimizing analysis errors due to a low probability of causing a non-specific reaction with a material in the sample.Type: ApplicationFiled: October 31, 2014Publication date: October 6, 2016Inventors: Sunyoung PARK, Jeongryul KIM, Seong Woo KIM, Kum-Joo SHIN, Ji-Chul LEE
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Publication number: 20160291039Abstract: A testing device for identifying an antigen or antibody within a biofluid sample including: a substrate having a hydrophilic surface thereon; the surface including a collection zone, and at least one detection zone extending therefrom; wherein the biofluid sample can be mixed with a specific antigen or antibody, and deposited on the collection zone and transferred by capillary action to the detection zone; the antigen or antibody in the biofluid sample reacting with an appropriate said antibody or antigen thereby resulting in a visual indication within the detection zone.Type: ApplicationFiled: June 7, 2016Publication date: October 6, 2016Inventors: Gil Garnier, Wei Shen, Mohidus Samad Khan, Xu Li, George Thouas
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Publication number: 20160291040Abstract: A sample analyzer includes: a preparation unit configured to mix a sample with a reagent to prepare a measurement specimen; a measurement unit configured to irradiate the measurement specimen with light to acquire optical time series data; and a controller configured to divide the time series data acquired by the measurement unit into data segments, determine first regression lines respectively of the data segments, select the first regression line with the highest matching degree with the time series data, set as an analysis target region a region of the time series data matching with the selected first regression line among the time series data acquired by the measurement unit, determine a second regression line using the time series data included in the set analysis target region, and perform an analysis using the second regression line.Type: ApplicationFiled: March 24, 2016Publication date: October 6, 2016Applicant: SYSMEX CORPORATIONInventor: Naoto KOSHIMURA
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Publication number: 20160291041Abstract: Disclosed is a method for measuring clotting time including: preparing a measurement sample by mixing a blood specimen suspected to contain a lupus anticoagulant, an activator, and a divalent-metal-ion-producing compound for facilitating formation of a phospholipid-containing complex; and measuring a clotting time after adding, to the measurement sample, an aqueous solution of a calcium salt as a coagulation initiator.Type: ApplicationFiled: March 28, 2016Publication date: October 6, 2016Applicants: SCHOOL JURIDICAL PERSON HIGASHI-NIPPON-GAKUEN, SYSMEX CORPORATIONInventors: Osamu KUMANO, Haruki YAMAGUCHI, Takeshi SUZUKI, Masahiro IEKO
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Publication number: 20160291042Abstract: Disclosed is a blood sample determination method including: preparing a mixed plasma by mixing a subject plasma and a normal plasma; emitting light to a measurement specimen obtained by mixing the mixed plasma and a clotting time measuring reagent, to obtain optical information regarding an amount of light from the measurement specimen; and determining whether the subject plasma is suspected to be a coagulation-factor-deficient plasma, on the basis of optical information obtained from one measurement specimen.Type: ApplicationFiled: March 28, 2016Publication date: October 6, 2016Applicants: SCHOOL JURIDICAL PERSON HIGASHI-NIPPON-GAKUEN, SYSMEX CORPORATIONInventors: Osamu KUMANO, Naohiko MATSUO, Nobuo ARAI, Masahiro IEKO
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Publication number: 20160291043Abstract: The present invention is directed to an assay that informs precision-based intrapleural fibrinolytic therapy (IPFT). Provided is a simple assay based on measurement of the Fibrinolytic Potential (FP)—total fibrinolytic activity in pleural fluid when plasminogen activator inhibitors (PAIs) are neutralized and endogenous plasminogen (PLG) is activated. The assay is used to determine FP in baseline pleural fluids of patients undergoing IPFT with agents such as tPA or scuPA to determine the dose and dose intervals for the particular patient. Pleural fluids are also collected after IPFT to confirm that intrapleural fibrinolysis is inhibited and endogenous PLG accumulates in the pleural fluid. Inhibition of intrapleural fibrinolysis in combination with its increase after supplementation of pleural fluid with a plasminogen activator indicates whether or not the subject should be treated with more or higher doses of an IPFT drug.Type: ApplicationFiled: March 31, 2016Publication date: October 6, 2016Inventors: Andrey A. Komissarov, Galina Florova, Steven Idell
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Publication number: 20160291044Abstract: This disclosure concerns plants, plant materials, and the oil characteristics thereof. In embodiments, compositions and methods for determining the total oil content of plant materials are provided. Such methods and compositions may in some embodiments allow for the characterization and screening of oil traits and sub-traits that are difficult or impossible to distinguish by conventional techniques.Type: ApplicationFiled: May 25, 2016Publication date: October 6, 2016Inventors: Thomas G. Patterson, Ted Freeman, Joshua A. Flook
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Publication number: 20160291045Abstract: Systems and methods that enable automated spray deposition of biological specimens carried on microscope slides are described herein. Aspects of the technology are directed, for example, to automated specimen deposition systems and methods of generating high-quality, reproducible specimen-bearing microscope slides in automated processing systems.Type: ApplicationFiled: April 6, 2016Publication date: October 6, 2016Inventors: Jarema Czarnecki, Justin Derbas, Sergey Rozhok, Hariharan Subramanian, Parvathi Viswanathan
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Publication number: 20160291046Abstract: A detection unit 113 measures scattered light intensity E as a coagulation index. A first curve fitting function 120B-a c calculates, at a predetermined time interval, a parameter for an approximate curve of a coagulation curve by curve fitting, based on the measured scattered light intensity E. An early reaction checking function 120B-b determines whether there is a lag phase as an early coagulation index change, based on the parameter for the approximate curve. The parameter has been calculated at the predetermined time interval by the first curve fitting function 120B-a. A clotting time calculation function 120B-f calculates clotting time, based on whether there is the lag phase.Type: ApplicationFiled: March 19, 2014Publication date: October 6, 2016Applicant: Hitachi High-Technologies CorporationInventors: Chie YABUTANI, Akihisa MAKINO, Sakuichiro ADACHI
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Publication number: 20160291047Abstract: A mass spectrometer system for analysis of clinical samples includes a source of clinical samples. A controller receives the clinical samples from the source of clinical samples. A sample preparation system receives clinical sample from the controller and processes the samples to produce an extract suitable for analysis by MALDI-TOF mass spectrometry and deposits the extract on a sample plate together with a MALDI matrix. A sample plate loading mechanism transports sample plates from the sample preparation system into an evacuated ion source of a MALDI-TOF mass spectrometer. A MALDI-TOF mass spectrometer ionizes and analyzes samples on the sample plate and generates a mass spectrum of components in the clinical samples. A computer system receives data from the MALDI-TOF mass spectrometer and processes and interprets the data to generate a mass spectrum.Type: ApplicationFiled: March 24, 2016Publication date: October 6, 2016Applicant: Virgin Instruments CorporationInventors: Marvin L. Vestal, Kevin Hayden
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Publication number: 20160291048Abstract: The purpose of the present invention is to provide an automatic analysis device that combines a biochemical analysis unit and a blood coagulation analysis unit and has a high processing capacity while reducing device cost and life-cycle cost. An automatic analysis device is characterized in that when a synthetic-substrate item or latex-agglutination item from among synthetic-substrate, latex-agglutination, and clotting-time blood-coagulation-test items is made to be a first test item and the clotting-time item is made to be a second test item, if there is a measurement request for the first test item and second test item in the same specimen rack, a control unit determines the conveyance path of the specimen rack such that the first test item is measured using a biochemical analysis unit and the second test item is measured using a coagulation time analysis unit and controls a conveyance line.Type: ApplicationFiled: November 5, 2014Publication date: October 6, 2016Inventors: Akihisa MAKINO, Chie YABUTANI, Masato ISHIZAWA
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METHODS AND APPARATUS FOR DETERMINING ASPIRATION AND/OR DISPENSING VOLUME AND/OR PIPETTE POSITIONING
Publication number: 20160291049Abstract: Methods of determining or verifying proper operation of a diagnostic device are disclosed. The methods include monitoring, with one or more image capture devices, one or more locations to determine proper aspiration, dispense, and/or overall assay component volume fill of one or more bio-liquid containers. Tip immersion depth and location may be also measured and/or verified. Diagnostic devices and apparatus adapted to carry out the method are described, as are other aspects.Type: ApplicationFiled: October 30, 2014Publication date: October 6, 2016Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Bharath K. Arumugam, Domenico Menafra -
Publication number: 20160291050Abstract: An inertial sensor includes a first sensor element, which is damped against vibrations from an interface of the inertial sensor by a damping element. The first sensor element is configured to detect a first measured variable in a first frequency band, and the damping element is configured to dampen vibrations at least in the first frequency band. The inertial sensor further includes a second sensor element, which is mechanically coupled to the interface. The second sensor element is configured to detect a second measured variable in a second frequency band.Type: ApplicationFiled: October 28, 2014Publication date: October 6, 2016Applicant: ROBERT BOSCH GMBHInventors: Ricardo Ehrenpfordt, Daniel Pantel, Frederik Ante
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Publication number: 20160291051Abstract: An air data probe is disclosed. The air data probe may include a probe body having an interior cavity and coated by a protective shell. A sensing port may be disposed in the air data probe and may extend through the probe body. The sensing port may also be lined by the protective shell. The protective shell may be made of an austenitic nickel-chromium alloy, or stainless steel, or any relatively corrosion resistant material. The probe body may be made of nickel, or a nickel alloy, or any relatively thermally conductive material. The protective shell may be joined to the probe body by additive manufacturing, such as laser cladding. In this manner, an air data probe capable withstanding high temperatures without corrosion and yet also being relatively thermally conductive is disclosed.Type: ApplicationFiled: February 17, 2016Publication date: October 6, 2016Applicant: Rosemount Aerospace, Inc.Inventors: Timothy Thomas Golly, Matthew P. Anderson, Paul Robert Johnson, Greg Seidel
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Publication number: 20160291052Abstract: The method of reducing error in rotor speed measurement includes synchronously measuring a rotor having a target including at least one geometric imperfection. Time intervals for the passing of each tooth of a rotor are stored in a circular buffer memory array. Speed is always determined by extracting the time for a complete revolution, so that geometric imperfections and asymmetry of the rotating target do not influence the speed determination, which is always representing the average speed over the latest complete revolution.Type: ApplicationFiled: November 7, 2014Publication date: October 6, 2016Inventors: Joseph Scott Riolo, David Allen Bradford
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Publication number: 20160291053Abstract: A scanning probe microscope has a cantilever having: a probe that is to be contacted or approached on a surface of a sample; and a processor that operates to perform a process including: calculating a measurement width MW and an offset value OV from a minimum value Smin and a maximum value Smax of a signal indicating a displacement of the cantilever with the following Equations (1) and (2) when a prescanning operation is performed before the measurement data is acquired by the probe microscope controller; and adjusting at least one of the offset value OV and the measurement width MW based on a temporal variation of the signal at the same position on the surface of the sample when the prescanning operation is performed.Type: ApplicationFiled: March 31, 2016Publication date: October 6, 2016Applicant: Hitachi High-Tech Science CorporationInventors: Masatsugu Shigeno, Yoshiteru Shikakura
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Publication number: 20160291054Abstract: A test probe tip can include a compliance member or force deflecting assembly and a tip component. The compliance member or force deflecting assembly can include a plunger component and a barrel component to receive the plunger component, wherein the plunger component is configured to slide axially inside the barrel component. The test probe tip can also include a spring mechanism within the barrel component to act on the plunger component, and a resistive/impedance element coupled with the plunger component at one end and with the tip component at the opposite end, the resistive/impedance element including at least one rod having a semi-cylindrical form and a resistive material situated thereon.Type: ApplicationFiled: April 1, 2015Publication date: October 6, 2016Inventors: William A. Hagerup, Julie A. Campbell, Ira G. Pollock, James E. Spinar, Kathleen F.M. Ullom, Charles M. Hartmann, Daniel J. Ayres, Christina D. Enns
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Publication number: 20160291055Abstract: A probe card comprises a probe; and a probe card substrate which includes a first member and a second member, the first member having a first surface provided with the probe and the second member having a second surface surrounding the first surface, wherein a direction of the first surface is different from a direction of the second surface.Type: ApplicationFiled: March 4, 2016Publication date: October 6, 2016Applicant: Kabushiki Kaisha ToshibaInventors: Tomoko FUJIWARA, Takao Sueyama, Keiko Kaneda, Michiko Ego
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Publication number: 20160291056Abstract: A test and measurement instrument including a splitter configured to split an input signal into at least two split signals, at least two harmonic mixers configured to mix an associated split signal with an associated harmonic signal to generate an associated mixed signal, at least two digitizers configured to digitize the associated mixed signal, at least two MIMO polyphase filter arrays configured to filter the associated digitized mixed signal of an associated digitizer of the at least two digitizers, at least two pairs of band separation filters configured to receive the associated digitized mixed signals from each of the MIMO polyphase filter arrays and output a low band of the input signal and a high band of the input signal based on a time different between the at least two digitizers and a phase drift of a local oscillator, and a combiner configured to combine the low band of the input signal and the high band of the input signal to form a reconstructed input signal.Type: ApplicationFiled: March 31, 2015Publication date: October 6, 2016Inventors: John J. Pickerd, Kan Tan
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Publication number: 20160291057Abstract: An automated test platform for testing a first device under test includes N voltage sources for providing N different voltages. A cross matrix switching system is coupled to the N voltage sources, the cross matrix switch being configured to provide the N different voltages to M discrete test points within the first device under test, wherein M is larger than N. An N voltage measuring system is coupled to the first device under test, the N voltage measuring system being configured to measure the voltage potential present on the M discrete test points.Type: ApplicationFiled: March 31, 2015Publication date: October 6, 2016Inventors: Wai-Kong Chen, David Harris
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Publication number: 20160291058Abstract: An interface test device for testing a circuit, the interface test device including a module assembly including a plurality of modules, wherein a test block assembly is formed from individual test blocks that are arranged at one another in parallel and fixated at one another, wherein a test plug assembly is formed from individual test plugs that are arranged at one another other in parallel and fixated at one another, wherein a movement of a lever arm out of a plane of an insertion direction of the test plug assembly into the test block assembly is transferred by strut elements to pinions of the test plug assembly and inserts test fingers of the test plug assembly into openings of the test block assembly, wherein one of the test fingers of the test plug assembly opens a medium to high voltage monitoring circuit.Type: ApplicationFiled: October 12, 2015Publication date: October 6, 2016Inventor: Hubert Ostmeier
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Publication number: 20160291059Abstract: Current sensors, systems and methods are provided. A test current is injected via a pair of force terminals into a conductor and a pair of sense terminals are configured to provide an input signal that corresponds to a voltage drop across the conductor. Based on the test current in the conductor and based on the input signal, a contribution to the voltage drop due to the test current and a contribution to the voltage drop due to a primary current through the conductor may be determined. In addition, at least one of a reference resistance of the conductor and the primary current in the conductor may be further determined.Type: ApplicationFiled: March 25, 2016Publication date: October 6, 2016Applicant: Infineon Technologies AGInventor: Udo Ausserlechner